MCID: MXD032
MIFTS: 31

Mixed Germ Cell Tumor malady

Cancer diseases category

Summaries for Mixed Germ Cell Tumor

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32MalaCards
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MalaCards: Mixed Germ Cell Tumor is related to choriocarcinoma and endodermal sinus tumor. An important gene associated with Mixed Germ Cell Tumor is AFP (alpha-fetoprotein), and among its related pathways are Insulin Processing and Glycoprotein hormones. The compounds vitamin k2 and ctp have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Mixed Germ Cell Tumor

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mixed germ cell tumor 48 60


External Ids:

SNOMED-CT via Orphanet57 32844007
UMLS via Orphanet61 C0334524

Related Diseases for Mixed Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma30.9ALPP, AFP, CGB, CGA
2endodermal sinus tumor30.6CGB, AFP, ALPP
3pancreatitis30.5ALPP
4gonadoblastoma30.5ALPP, POU5F1
5teratocarcinoma30.2POU5F1
6ganglioneuroma30.2PTEN
7adenoma30.2CGB, CGA
8pituitary adenoma30.2POU5F1, CGA
9seminoma30.2ALPP, SOX2, CGA, CGB, AFP, POU5F1
10mature teratoma10.6
11malignant teratoma10.5
12mediastinitis10.5
13childhood testicular mixed germ cell tumor10.4
14choriocarcinoma of ovary10.4
15giant cell tumor10.4
16epithelioid trophoblastic tumor10.3
17adult central nervous system mixed germ cell tumor10.3
18childhood central nervous system mixed germ cell tumor10.3
19ovarian endodermal sinus tumor10.3
20mixed germ cell tumor of the central nervous system10.3
21smith-lemli-opitz syndrome10.2
22mixed cell adenoma10.2
23cryptorchidism10.2
24ovarian gonadoblastoma10.2
25embryoma10.2
26ovarian cystic teratoma10.2
27diabetes insipidus10.2
28testis rhabdomyosarcoma10.2
29polyembryoma of the ovary10.2
30cowden disease10.2
31microcystic meningioma10.2
32retroperitoneal germ cell neoplasm10.2
33mixed gonadal dysgenesis10.2
34ovarian mixed germ cell neoplasm10.2
35craniopharyngioma10.2
36cystic teratoma10.2
37gonadal dysgenesis10.2
38hemangioblastoma10.2
39hemangioma10.2
40hemangioma of lung10.2
41hemangiopericytoma10.2
42islet cell tumor10.2
43leukemia10.2
44meningioma10.2
45mixed glioma10.2
46myopathy10.2
47neuroblastoma10.2
48pediatric testicular germ cell tumor10.2
49prostatitis10.2
50pseudohermaphroditism10.2

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to mixed germ cell tumor

Clinical Features for Mixed Germ Cell Tumor

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Drugs & Therapeutics for Mixed Germ Cell Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mixed Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Mixed Germ Cell Tumor

Search NIH Clinical Center for Mixed Germ Cell Tumor

Search CenterWatch for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

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Anatomical Context for Mixed Germ Cell Tumor

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Animal Models for Mixed Germ Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mixed Germ Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PTEN, AFP, CGA, SOX2
2MP:00053797.8SOX2, CGA, AFP, POU5F1, PTEN
3MP:00053807.5SOX2, POU5F1, GDF3, PTEN, ALPP
4MP:00028737.3SOX2, POU5F1, GDF3, PTEN, ALPP
5MP:00107687.2ALPP, PTEN, GDF3, POU5F1, AFP, SOX2

Publications for Mixed Germ Cell Tumor

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Genetic Variations for Mixed Germ Cell Tumor

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Expression for genes affiliated with Mixed Germ Cell Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Germ Cell Tumor

Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

Pathways for genes affiliated with Mixed Germ Cell Tumor

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Mixed Germ Cell Tumor

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1vitamin k2449.9ALPP, AFP
2ctp449.8CGB, CGA
3hydroxyflutamide44 2810.8ALPP, CGA
4oestriol449.7AFP, CGB, CGA
5clomiphene citrate449.7AFP, CGB, CGA
6ifosfamide44 1110.7AFP, CGB, CGA
7b 723449.7ALPP, AFP
8bleomycin44 1110.7AFP, CGB, CGA
9mifepristone44 59 28 1112.6CGA, CGB, AFP
10phenytoin44 49 28 1112.6ALPP, CGA
11folate449.4CGA, AFP, ALPP
12methotrexate44 49 1111.4CGA, CGB, AFP
13dmso449.4ALPP, AFP, CGA
14diethylstilbestrol44 28 1111.3PTEN, AFP, CGA
15thyroxine44 2410.2CGA, CGB, AFP, ALPP
16vincristine44 49 1111.2CGB, AFP, PTEN
17lactate449.1ALPP, AFP, CGB, CGA
18creatinine449.1ALPP, AFP, CGB, CGA
19cyclophosphamide44 49 1110.9CGA, CGB, AFP, PTEN
20norepinephrine44 11 2410.9CGA, POU5F1, ALPP
21etoposide44 49 59 1111.8CGA, CGB, AFP, PTEN
22estradiol44 11 2410.8CGA, CGB, AFP, PTEN
23vitamin d448.8ALPP, PTEN, AFP, CGA
24tamoxifen44 49 28 1111.8ALPP, PTEN, CGA
25paraffin448.7CGA, AFP, PTEN, ALPP
26progesterone44 59 28 11 2412.7CGA, CGB, AFP, PTEN
27aspartate448.7CGA, AFP, PTEN, ALPP
28doxorubicin44 49 1110.6PTEN, AFP, CGA
29h2o2448.6ALPP, PTEN, AFP, CGA
30cisplatin44 49 59 1111.4CGA, CGB, AFP, PTEN, ALPP
31testosterone44 59 11 2411.3CGA, CGB, AFP, PTEN, ALPP
32alanine448.3CGA, CGB, AFP, PTEN, ALPP
33retinoic acid44 249.0ALPP, PTEN, POU5F1, AFP, SOX2
34vegf447.7CGA, CGB, AFP, POU5F1, PTEN, ALPP

GO Terms for genes affiliated with Mixed Germ Cell Tumor

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Sources:
16Gene Ontology
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Biological processes related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGB, CGA
2eye developmentGO:0016549.6GDF3, SOX2
3endodermal cell fate specificationGO:0017149.5POU5F1, SOX2
4negative regulation of organ growthGO:0466219.4PTEN, CGA
5somatic stem cell maintenanceGO:0350199.3SOX2, POU5F1
6response to woundingGO:0096119.3POU5F1, SOX2
7regulation of gene expressionGO:0104689.0POU5F1, SOX2
8negative regulation of epithelial cell proliferationGO:0506809.0PTEN, SOX2

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.3POU5F1, SOX2

Products for genes affiliated with Mixed Germ Cell Tumor

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  • Antibodies
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Sources for Mixed Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet