MCID: MXD032
MIFTS: 44

Mixed Germ Cell Tumor malady

Cancer diseases, Rare diseases categories
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Summaries for Mixed Germ Cell Tumor

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MalaCards based summary: Mixed Germ Cell Tumor is related to choriocarcinoma and endodermal sinus tumor. An important gene associated with Mixed Germ Cell Tumor is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide hormone metabolism. The compounds ctp and vinblastine have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and pineal, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Mixed Germ Cell Tumor

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
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Mixed Germ Cell Tumor, Aliases & Descriptions:

Name: Mixed Germ Cell Tumor 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


External Ids:

UMLS via Orphanet63 C0334524

Related Diseases for Mixed Germ Cell Tumor

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Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma31.0ALPP, CGB, AFP, CGA
2endodermal sinus tumor30.7ALPP, AFP, CGB
3gonadoblastoma30.6ALPP, POU5F1
4cryptorchidism30.6CGA, ALPP
5dysgerminoma30.2AFP, POU5F1, ALPP, CGA
6teratoma30.2CGB, SOX2, ALPP, CGA, POU5F1, AFP
7germinoma30.1ALPP, CGA, AFP, POU5F1, CGB
8seminoma29.3CGA, AFP, SOX2, POU5F1, ALPP, CGB
9germ cell tumors11.3
10polyembryoma10.7
11mature teratoma10.6
12mediastinitis10.5
13childhood testicular mixed germ cell tumor10.5
14mixed germ cell tumor of the central nervous system10.5
15extragonadal germ cell tumor10.5AFP
16oligohydramnios10.5AFP
17leydig cell tumor10.4CGA
18adult central nervous system mixed germ cell tumor10.4
19childhood central nervous system mixed germ cell tumor10.4
20ovarian mixed germ cell neoplasm10.4
21epithelioid trophoblastic tumor10.4
22pancreatitis10.4
23precocious puberty10.4
24testicular microlithiasis10.4
25growing teratoma syndrome10.4
26sertoli cell tumor10.4ALPP
27male germ cell tumor, somatic10.3CGA, AFP
28edwards syndrome10.3AFP, CGA
29anencephaly10.3AFP, CGA
30coloboma10.3SOX2
31placental site trophoblastic tumor10.3CGB, CGA
32gestational trophoblastic tumor10.3CGB, CGA
33ectopic pregnancy10.3CGA, CGB
34testicular cancer10.3ALPP, AFP
35pineoblastoma10.3POU5F1
36hyperprolactinemia10.3CGB, CGA
37turner syndrome10.2CGB, CGA
38hemangioma10.2
39leukemia10.2
40smith-lemli-opitz syndrome10.2
41cowden disease10.2
42diabetes insipidus10.2
43microcystic meningioma10.2
44embryoma10.2
45ganglioneuroma10.2
46teratocarcinoma10.2
47ovarian gonadoblastoma10.2
48adenoma10.2
49craniopharyngioma10.2
50cystic teratoma10.2

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to mixed germ cell tumor

Symptoms for Mixed Germ Cell Tumor

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Drugs & Therapeutics for Mixed Germ Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Mixed Germ Cell Tumor

Search NIH Clinical Center for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

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Anatomical Context for Mixed Germ Cell Tumor

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MalaCards organs/tissues related to Mixed Germ Cell Tumor:

32
Ovary, Testis, Pineal, Pituitary, Brain, Skin, Eye, Cerebellum, Heart, Kidney, Liver, Lung, Prostate, Temporal lobe

Animal Models for Mixed Germ Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Mixed Germ Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CGA, SOX2, PTEN, AFP, GDF3
2MP:00053797.9AFP, PTEN, SOX2, POU5F1, CGA
3MP:00053807.6ALPP, POU5F1, SOX2, PTEN, GDF3
4MP:00028737.5GDF3, PTEN, SOX2, POU5F1, ALPP
5MP:00053787.5GDF3, PTEN, SOX2, ALPP, CGA
6MP:00053897.4CGA, ALPP, POU5F1, SOX2, PTEN, AFP
7MP:00107687.1GDF3, AFP, PTEN, SOX2, POU5F1, ALPP

Publications for Mixed Germ Cell Tumor

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Articles related to Mixed Germ Cell Tumor:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
A 23-year-old female with a mixed germ cell tumor of the pituitary infundibulum: the challenge of differentiating neoplasm from lymphocytic infundibuloneurohypophysitis-a case report and literature review. (25045548)
2014
2
Equine Placental Mixed Germ Cell Tumor With Metastasis to the Foal. (24823807)
2014
3
Primary ovarian malignant melanoma arising in teratomatous component of mixed- germ cell tumor in a child: case report. (24499012)
2014
4
Intratumoral hemorrhage because of primary spinal mixed germ cell tumor presenting with atypical radiological features in an adult. (23953732)
2013
5
Mixed germ cell tumor of mediastinum/lung masquerading as hemangioma in fine needle biopsy. (24056656)
2013
6
Mixed germ cell tumor with extensive yolk sac tumor elements in the frontal lobe of an adult. (23326746)
2012
7
Extragonadal mixed germ cell tumor of the right arm: description of the first case in the literature. (22540884)
2012
8
Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. (21287366)
2011
9
Can stereotactic sample biopsies accurately diagnose mixed germ cell tumors? (21541683)
2011
10
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. (21519041)
2011
11
Mixed germ cell tumor and hemangioblastoma in the cerebellum: report of a rare coexistence. (21442239)
2011
12
Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma. (19116786)
2011
13
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
14
Primary mixed germ cell tumor of the liver with sarcomatous components. (20128038)
2010
15
Mixed germ cell tumor metastatic to the skin: case report and literature review. (20331874)
2010
16
Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge. (19099195)
2009
17
Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis. (18407327)
2009
18
Blunt testicular trauma results in rupture of mixed germ cell tumor. (20003680)
2009
19
Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass. (19201104)
2009
20
Metachronous gliomas following cranial irradiation for mixed germ cell tumors. (19247675)
2009
21
Mixed germ cell tumor of the midbrain. Case Report. (19645547)
2009
22
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
23
Mixed germ cell tumors in septum pellucidum after radiochemotherapy of suprasellar germinoma: de novo metachronous or recurrent neoplasms? (18560841)
2008
24
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. (18574668)
2008
25
Congenital cerebellar mixed germ cell tumor presenting with hemorrhage in a newborn. (18607121)
2008
26
Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature. (19197460)
2008
27
Malignant ganglioneuroma arising from mediastinal mixed germ cell tumor. (17339149)
2007
28
Testicular mixed germ cell tumor in an adolescent with cowden disease. (18160807)
2007
29
Twisted mixed germ cell tumor of the ovary in a child. (16883461)
2006
30
Different transformation of mature teratoma in a patient with mixed germ cell tumor of the testis. (15985085)
2005
31
Expression of CD34 antigen in testicular mixed germ cell tumor. (14629751)
2003
32
Dysgerminoma with a slightly elevated alpha-fetoprotein level diagnosed as a mixed germ cell tumor after recurrence. (12624554)
2003
33
Pelvic hemangiopericytoma in a patient with mixed germ cell tumor of the testis. (11586234)
2001
34
Cardiac metastasis from testicular mixed germ cell tumor. (11594415)
2001
35
Retroperitoneal mature teratoma 15 years after initial treatment of testicular mixed germ cell tumor. (11096252)
2000
36
An adult patient with a mixed germ cell tumor of the spermatic cord. (10754174)
2000
37
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. (10849320)
2000
38
Ovarian mixed germ cell tumor composed of endodermal sinus tumor and immature teratoma: case report. (10968342)
2000
39
Intrarenal mixed germ cell tumor. (11061908)
2000
40
Mixed germ cell tumor of the testicle presenting with a sacrococcygeal mass and no evidence of retroperitoneal adenopathy. (10379766)
1999
41
Neuroradiology case of the day. Malignant mixed germ cell tumor with yolk sac and teratomatous components. (10336209)
1999
42
Microcystic meningioma arising in a mixed germ cell tumor of the testis: a case report. (10478675)
1999
43
Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland. (9496542)
1998
44
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
45
Neuroblastoma as a prominent component of a mixed germ cell tumor of testis. (8242553)
1993
46
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
47
Associated leukemia and mixed germ cell tumor in a patient with gonadal dysgenesis. (1680081)
1991
48
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
49
Intrasellar mixed germ-cell tumor. Case report. (6834126)
1983
50
Serum alphafetoprotein (AFP) in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. (75054)
1978

Variations for Mixed Germ Cell Tumor

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Expression for genes affiliated with Mixed Germ Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Mixed Germ Cell Tumor

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Pathways for genes affiliated with Mixed Germ Cell Tumor

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Compounds for genes affiliated with Mixed Germ Cell Tumor

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Compounds related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1ctp4410.0CGB, CGA
2vinblastine44 50 1112.0AFP, CGA
3vitamin k24410.0ALPP, AFP
4hydroxyflutamide44 2810.9CGA, ALPP
5b 723449.9ALPP, AFP
6vitamin b12449.9AFP, ALPP
7phenytoin44 50 28 1112.9ALPP, CGA
8androstenedione44 2410.8CGA, CGB
9oestriol449.8CGA, CGB, AFP
10clomiphene citrate449.8CGA, CGB, AFP
11ifosfamide44 1110.8CGA, CGB, AFP
12carboplatin44 50 1111.8AFP, CGA
13bleomycin44 1110.7CGA, CGB, AFP
14mifepristone44 28 61 1112.7CGA, CGB, AFP
15progestin449.7CGA, ALPP
16methotrexate50 44 1111.7CGA, CGB, AFP
17folate449.6AFP, ALPP, CGA
18dmso449.6CGA, ALPP, AFP
19polyethylene glycol449.5ALPP, AFP
20heparin44 28 24 1112.5CGA, ALPP, AFP
21diethylstilbestrol44 28 1111.4AFP, PTEN, CGA
22latex449.3ALPP, AFP
23vincristine44 50 1111.3CGB, PTEN, AFP
24thyroxine44 2410.3AFP, ALPP, CGB, CGA
25norepinephrine44 24 1111.3POU5F1, ALPP, CGA
26doxorubicin44 50 1111.2CGA, PTEN, AFP
27lactate449.2AFP, ALPP, CGB, CGA
28creatinine449.2AFP, ALPP, CGB, CGA
29tamoxifen44 50 28 1112.1PTEN, ALPP, CGA
30cyclic amp44 2410.1CGA, CGB, PTEN
31pge2449.0CGA, ALPP, PTEN
32cyclophosphamide44 50 1111.0CGA, CGB, PTEN, AFP
33etoposide44 50 61 1112.0AFP, PTEN, CGB, CGA
34cycloheximide448.9PTEN, ALPP, CGA
35estradiol44 24 1110.9AFP, PTEN, CGB, CGA
36progesterone44 28 61 24 1112.9AFP, PTEN, CGB, CGA
37vitamin d448.8AFP, PTEN, ALPP, CGA
38paraffin448.8AFP, PTEN, ALPP, CGA
39aspartate448.8AFP, PTEN, ALPP, CGA
40cholesterol44 28 24 1111.8ALPP, PTEN, AFP
41h2o2448.8CGA, ALPP, PTEN, AFP
42serine448.5AFP, PTEN, ALPP, CGA
43cisplatin44 50 61 1111.4AFP, PTEN, ALPP, CGB, CGA
44testosterone44 61 24 1111.4AFP, PTEN, ALPP, CGB, CGA
45alanine448.4CGA, CGB, ALPP, PTEN, AFP
46estrogen448.4AFP, PTEN, ALPP, CGB, CGA
47retinoic acid44 249.1ALPP, POU5F1, SOX2, PTEN, AFP
48vegf447.8AFP, PTEN, POU5F1, ALPP, CGB, CGA

GO Terms for genes affiliated with Mixed Germ Cell Tumor

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Biological processes related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGA, CGB
2eye developmentGO:0016549.6SOX2, GDF3
3endodermal cell fate specificationGO:0017149.5POU5F1, SOX2
4negative regulation of organ growthGO:0466219.4CGA, PTEN
5somatic stem cell maintenanceGO:0350199.3SOX2, POU5F1
6regulation of gene expressionGO:0104689.3POU5F1, SOX2
7response to woundingGO:0096119.0POU5F1, SOX2
8negative regulation of epithelial cell proliferationGO:0506809.0SOX2, PTEN

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7CGA, CGB
2miRNA bindingGO:0351989.0POU5F1, SOX2

Products for genes affiliated with Mixed Germ Cell Tumor

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Sources for Mixed Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet