MCID: MXD032
MIFTS: 39

Mixed Germ Cell Tumor malady

Cancer diseases, Rare diseases categories

Summaries for Mixed Germ Cell Tumor

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MalaCards based summary: Mixed Germ Cell Tumor is related to ovarian mixed germ cell neoplasm and choriocarcinoma. An important gene associated with Mixed Germ Cell Tumor is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide hormone metabolism. The compounds ctp and vinblastine have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and pineal, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Mixed Germ Cell Tumor

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Mixed Germ Cell Tumor, Aliases & Descriptions:

Name: Mixed Germ Cell Tumor 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


External Ids:

Orphanet47 180234
UMLS via Orphanet61 C0334524

Related Diseases for Mixed Germ Cell Tumor

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Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian mixed germ cell neoplasm31.1AFP, CGA
2choriocarcinoma31.0ALPP, CGB, AFP, CGA
3endodermal sinus tumor30.7ALPP, AFP, CGB
4cryptorchidism30.6CGA, ALPP
5gonadoblastoma30.6ALPP, POU5F1
6dysgerminoma30.2AFP, POU5F1, ALPP, CGA
7teratoma30.2CGB, SOX2, ALPP, CGA, POU5F1, AFP
8germinoma30.1ALPP, CGA, AFP, POU5F1, CGB
9seminoma29.3CGA, AFP, SOX2, POU5F1, ALPP, CGB
10polyembryoma10.7
11mature teratoma10.6
12childhood testicular mixed germ cell tumor10.5
13mediastinitis10.5
14mixed germ cell tumor of the central nervous system10.5
15adult central nervous system mixed germ cell tumor10.5
16childhood central nervous system mixed germ cell tumor10.5
17extragonadal germ cell tumor10.5AFP
18oligohydramnios10.4AFP
19testicular microlithiasis10.4
20epithelioid trophoblastic tumor10.4
21pancreatitis10.4
22precocious puberty10.4
23leydig cell tumor10.4CGA
24sertoli cell tumor10.4ALPP
25testicular teratoma10.3CGA, AFP
26edwards syndrome10.3AFP, CGA
27anencephaly10.3AFP, CGA
28coloboma10.3SOX2
29placental site trophoblastic tumor10.3CGB, CGA
30gestational trophoblastic tumor10.3CGB, CGA
31ectopic pregnancy10.3CGA, CGB
32testicular cancer10.3ALPP, AFP
33smith-lemli-opitz syndrome10.2
34neuroblastoma10.2
35burns10.2
36hemangioma10.2
37leukemia10.2
38diabetes insipidus10.2
39cowden disease10.2
40microcystic meningioma10.2
41teratocarcinoma10.2
42ovarian gonadoblastoma10.2
43embryoma10.2
44ganglioneuroma10.2
45adenoma10.2
46craniopharyngioma10.2
47cystic teratoma10.2
48gonadal dysgenesis10.2
49hemangioblastoma10.2
50hemangiopericytoma10.2

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to mixed germ cell tumor

Symptoms for Mixed Germ Cell Tumor

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Drugs & Therapeutics for Mixed Germ Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Mixed Germ Cell Tumor

Search NIH Clinical Center for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

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Anatomical Context for Mixed Germ Cell Tumor

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MalaCards organs/tissues related to Mixed Germ Cell Tumor:

31
Ovary, Testis, Pineal, Pituitary, Brain, Skin, Eye, Cerebellum, Heart, Kidney, Liver, Lung, Prostate, Temporal lobe

Animal Models for Mixed Germ Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Mixed Germ Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CGA, SOX2, PTEN, AFP, GDF3
2MP:00053797.9AFP, PTEN, SOX2, POU5F1, CGA
3MP:00053807.6ALPP, POU5F1, SOX2, PTEN, GDF3
4MP:00028737.5GDF3, PTEN, SOX2, POU5F1, ALPP
5MP:00053787.5GDF3, PTEN, SOX2, ALPP, CGA
6MP:00053897.4CGA, ALPP, POU5F1, SOX2, PTEN, AFP
7MP:00107687.1GDF3, AFP, PTEN, SOX2, POU5F1, ALPP

Publications for Mixed Germ Cell Tumor

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Articles related to Mixed Germ Cell Tumor:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Pelvic and right ovarian mature teratomas with malignant mixed germ cell tumors of the anterior abdominal wall. (25794818)
2015
2
A 23-year-old female with a mixed germ cell tumor of the pituitary infundibulum: the challenge of differentiating neoplasm from lymphocytic infundibuloneurohypophysitis-a case report and literature review. (25045548)
2014
3
Equine Placental Mixed Germ Cell Tumor With Metastasis to the Foal. (24823807)
2014
4
Primary ovarian malignant melanoma arising in teratomatous component of mixed- germ cell tumor in a child: case report. (24499012)
2014
5
Burned-out in a mixed germ cell tumor of the testis: the problem of pT0. Case report. (25641479)
2014
6
Intratumoral hemorrhage because of primary spinal mixed germ cell tumor presenting with atypical radiological features in an adult. (23953732)
2013
7
Mixed germ cell tumor of mediastinum/lung masquerading as hemangioma in fine needle biopsy. (24056656)
2013
8
Mixed germ cell tumor with extensive yolk sac tumor elements in the frontal lobe of an adult. (23326746)
2012
9
Extragonadal mixed germ cell tumor of the right arm: description of the first case in the literature. (22540884)
2012
10
Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. (21287366)
2011
11
Can stereotactic sample biopsies accurately diagnose mixed germ cell tumors? (21541683)
2011
12
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. (21519041)
2011
13
Mixed germ cell tumor and hemangioblastoma in the cerebellum: report of a rare coexistence. (21442239)
2011
14
Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma. (19116786)
2011
15
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
16
Primary mixed germ cell tumor of the liver with sarcomatous components. (20128038)
2010
17
Mixed germ cell tumor metastatic to the skin: case report and literature review. (20331874)
2010
18
Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge. (19099195)
2009
19
Mixed germ cell tumor of the testicle with ravdomuosarcomatous component: a case report. (20062623)
2009
20
Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis. (18407327)
2009
21
Blunt testicular trauma results in rupture of mixed germ cell tumor. (20003680)
2009
22
Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass. (19201104)
2009
23
Metachronous gliomas following cranial irradiation for mixed germ cell tumors. (19247675)
2009
24
Mixed germ cell tumor of the midbrain. Case Report. (19645547)
2009
25
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
26
Mixed germ cell tumors in septum pellucidum after radiochemotherapy of suprasellar germinoma: de novo metachronous or recurrent neoplasms? (18560841)
2008
27
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. (18574668)
2008
28
Congenital cerebellar mixed germ cell tumor presenting with hemorrhage in a newborn. (18607121)
2008
29
Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature. (19197460)
2008
30
Malignant ganglioneuroma arising from mediastinal mixed germ cell tumor. (17339149)
2007
31
Testicular mixed germ cell tumor in an adolescent with cowden disease. (18160807)
2007
32
Twisted mixed germ cell tumor of the ovary in a child. (16883461)
2006
33
Giant testicular mixed germ cell tumor. a case report. (14755145)
2004
34
Expression of CD34 antigen in testicular mixed germ cell tumor. (14629751)
2003
35
Dysgerminoma with a slightly elevated alpha-fetoprotein level diagnosed as a mixed germ cell tumor after recurrence. (12624554)
2003
36
Pelvic hemangiopericytoma in a patient with mixed germ cell tumor of the testis. (11586234)
2001
37
Cardiac metastasis from testicular mixed germ cell tumor. (11594415)
2001
38
Retroperitoneal mature teratoma 15 years after initial treatment of testicular mixed germ cell tumor. (11096252)
2000
39
An adult patient with a mixed germ cell tumor of the spermatic cord. (10754174)
2000
40
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. (10849320)
2000
41
Mixed germ cell tumor of the testicle presenting with a sacrococcygeal mass and no evidence of retroperitoneal adenopathy. (10379766)
1999
42
Neuroradiology case of the day. Malignant mixed germ cell tumor with yolk sac and teratomatous components. (10336209)
1999
43
Microcystic meningioma arising in a mixed germ cell tumor of the testis: a case report. (10478675)
1999
44
Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland. (9496542)
1998
45
Neuroblastoma as a prominent component of a mixed germ cell tumor of testis. (8242553)
1993
46
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
47
Associated leukemia and mixed germ cell tumor in a patient with gonadal dysgenesis. (1680081)
1991
48
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
49
Intrasellar mixed germ-cell tumor. Case report. (6834126)
1983
50
Serum alphafetoprotein (AFP) in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. (75054)
1978

Variations for Mixed Germ Cell Tumor

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Expression for genes affiliated with Mixed Germ Cell Tumor

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Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

Pathways for genes affiliated with Mixed Germ Cell Tumor

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Pathways related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CGA, AFP
2
Show member pathways
9.7CGA, CGB
39.3SOX2, POU5F1
49.3POU5F1, SOX2
59.3SOX2, POU5F1
69.3POU5F1, SOX2
79.1ALPP, PTEN
89.0AFP, SOX2, POU5F1
9
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.5POU5F1, SOX2, PTEN

Compounds for genes affiliated with Mixed Germ Cell Tumor

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Compounds related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 48)
idCompoundScoreTop Affiliating Genes
1ctp4310.0CGB, CGA
2vinblastine43 49 1212.0AFP, CGA
3vitamin k24310.0ALPP, AFP
4hydroxyflutamide43 2810.9CGA, ALPP
5b 723439.9ALPP, AFP
6vitamin b12439.9AFP, ALPP
7phenytoin43 49 28 1212.9ALPP, CGA
8androstenedione43 2410.8CGA, CGB
9oestriol439.8CGA, CGB, AFP
10clomiphene citrate439.8CGA, CGB, AFP
11ifosfamide43 1210.8CGA, CGB, AFP
12carboplatin43 49 1211.8AFP, CGA
13bleomycin43 1210.7CGA, CGB, AFP
14mifepristone43 28 59 1212.7CGA, CGB, AFP
15progestin439.7CGA, ALPP
16methotrexate49 43 1211.7CGA, CGB, AFP
17folate439.6AFP, ALPP, CGA
18dmso439.6CGA, ALPP, AFP
19polyethylene glycol439.5ALPP, AFP
20heparin43 28 24 1212.5CGA, ALPP, AFP
21diethylstilbestrol43 28 1211.4AFP, PTEN, CGA
22latex439.3ALPP, AFP
23vincristine43 49 1211.3CGB, PTEN, AFP
24thyroxine43 2410.3AFP, ALPP, CGB, CGA
25norepinephrine43 24 1211.3POU5F1, ALPP, CGA
26doxorubicin43 49 1211.2CGA, PTEN, AFP
27lactate439.2AFP, ALPP, CGB, CGA
28creatinine439.2AFP, ALPP, CGB, CGA
29tamoxifen43 49 28 1212.1PTEN, ALPP, CGA
30cyclic amp43 2410.1CGA, CGB, PTEN
31pge2439.0CGA, ALPP, PTEN
32cyclophosphamide43 49 1211.0CGA, CGB, PTEN, AFP
33etoposide43 49 59 1212.0AFP, PTEN, CGB, CGA
34cycloheximide438.9PTEN, ALPP, CGA
35estradiol43 24 1210.9AFP, PTEN, CGB, CGA
36progesterone43 28 59 24 1212.9AFP, PTEN, CGB, CGA
37vitamin d438.8AFP, PTEN, ALPP, CGA
38paraffin438.8AFP, PTEN, ALPP, CGA
39aspartate438.8AFP, PTEN, ALPP, CGA
40cholesterol43 28 24 1211.8ALPP, PTEN, AFP
41h2o2438.8CGA, ALPP, PTEN, AFP
42serine438.5AFP, PTEN, ALPP, CGA
43cisplatin43 49 59 1211.4AFP, PTEN, ALPP, CGB, CGA
44testosterone43 59 24 1211.4AFP, PTEN, ALPP, CGB, CGA
45alanine438.4CGA, CGB, ALPP, PTEN, AFP
46estrogen438.4AFP, PTEN, ALPP, CGB, CGA
47retinoic acid43 249.1ALPP, POU5F1, SOX2, PTEN, AFP
48vegf437.8AFP, PTEN, POU5F1, ALPP, CGB, CGA

GO Terms for genes affiliated with Mixed Germ Cell Tumor

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Biological processes related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.8CGA, CGB
2eye developmentGO:00016549.6SOX2, GDF3
3endodermal cell fate specificationGO:00017149.5POU5F1, SOX2
4negative regulation of organ growthGO:00466219.4CGA, PTEN
5somatic stem cell maintenanceGO:00350199.3SOX2, POU5F1
6regulation of gene expressionGO:00104689.3POU5F1, SOX2
7response to woundingGO:00096119.0POU5F1, SOX2
8negative regulation of epithelial cell proliferationGO:00506809.0SOX2, PTEN

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.7CGA, CGB
2miRNA bindingGO:00351989.0POU5F1, SOX2

Products for genes affiliated with Mixed Germ Cell Tumor

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Sources for Mixed Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet