MCID: MXD032
MIFTS: 40

Mixed Germ Cell Tumor malady

Cancer category

Summaries for Mixed Germ Cell Tumor

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33MalaCards
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MalaCards: Mixed Germ Cell Tumor is related to teratoma and germinoma. An important gene associated with Mixed Germ Cell Tumor is AFP (alpha-fetoprotein), and among its related pathways are Insulin Processing and Glycoprotein hormones. The compounds vitamin k2 and ctp have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Mixed Germ Cell Tumor

Sources:
49Orphanet, 61UMLS, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

mixed germ cell tumor 49 61


External Ids:

SNOMED-CT via Orphanet58 32844007
UMLS via Orphanet62 C0334524

Related Diseases for Mixed Germ Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.1SOX2, CGA, CGB, AFP, POU5F1, ALPP
2germinoma30.7CGA, CGB, AFP, POU5F1, ALPP
3gonadoblastoma30.5ALPP, POU5F1
4dysgerminoma30.5CGA, AFP, POU5F1, ALPP
5extragonadal germ cell tumor30.3AFP
6teratocarcinoma30.3POU5F1
7ganglioneuroma30.3PTEN
8adenoma30.3CGB, CGA
9turner syndrome30.3CGB, CGA
10testicular germ cell tumor10.8
11ovarian germ cell tumor10.8
12malignant germ cell tumor10.7
13germ cell tumors10.7
14polyembryoma10.6
15epithelioid trophoblastic tumor10.4
16adult central nervous system mixed germ cell tumor10.4
17childhood central nervous system mixed germ cell tumor10.4
18precocious puberty10.4
19testicular microlithiasis10.4
20male germ cell tumor10.4
21mixed germ cell tumor of the central nervous system10.4
22growing teratoma syndrome10.4
23ovarian germ cell malignant tumor10.4
24smith-lemli-opitz syndrome10.2
25mixed cell adenoma10.2
26cryptorchidism10.2
27ovarian gonadoblastoma10.2
28embryoma10.2
29ovarian cystic teratoma10.2
30diabetes insipidus10.2
31testis rhabdomyosarcoma10.2
32malignant ovarian cyst10.2
33cowden disease10.2
34microcystic meningioma10.2
35retroperitoneal germ cell neoplasm10.2
36mixed gonadal dysgenesis10.2
37ovarian mixed germ cell neoplasm10.2
38t-cell leukemia10.2
39testicular disease10.2
40testis seminoma10.2
41young syndrome10.2
42swyer syndrome10.2
43heart tumor10.2
44polymyositis10.2
45testicular tumor, somatic10.2
46leydig cell tumor10.0CGA
47thyroiditis10.0CGA
48hypothyroidism10.0CGA
49sarcoma10.0CGB
50sertoli-leydig cell tumor10.0AFP

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to mixed germ cell tumor

Clinical Features for Mixed Germ Cell Tumor

Drugs & Therapeutics for Mixed Germ Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mixed Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Mixed Germ Cell Tumor

Search NIH Clinical Center for Mixed Germ Cell Tumor

Search CenterWatch for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

Anatomical Context for Mixed Germ Cell Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Mixed Germ Cell Tumor:

33
Brain, Cerebellum, Spinal cord, Heart, Kidney, Liver, Lung, Pancreas, Skin, Ovary, Prostate, Testis, Temporal lobe, Pancreatic islet, Pineal, Pituitary, Testis germ, Testis leydig

Animal Models for Mixed Germ Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Mixed Germ Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PTEN, AFP, CGA, SOX2
2MP:00053797.8SOX2, CGA, AFP, POU5F1, PTEN
3MP:00053807.5SOX2, POU5F1, GDF3, PTEN, ALPP
4MP:00028737.3SOX2, POU5F1, GDF3, PTEN, ALPP
5MP:00107687.2ALPP, PTEN, GDF3, POU5F1, AFP, SOX2

Publications for Mixed Germ Cell Tumor

Sources:
51PubMed
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Articles related to Mixed Germ Cell Tumor:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Isolated retroperitoneal mixed germ cell tumor presenting as acute abdomen - case report. (23788970)
2013
2
Primary mixed germ cell tumor arising in the pancreatic head. (23331834)
2013
3
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. (22734844)
2012
4
Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. (21287366)
2011
5
Primary mixed germ cell tumor of the liver with sarcomatous components. (20128038)
2010
6
Mixed germ cell tumor metastatic to the skin: case report and literature review. (20331874)
2010
7
Primary mixed epithelial and germ cell tumors of the ovary. Two case reports and literature review. (21319527)
2010
8
An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor. (20173766)
2010
9
Blunt testicular trauma results in rupture of mixed germ cell tumor. (20003680)
2009
10
Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass. (19201104)
2009
11
Metastatic epithelioid trophoblastic tumor in a male patient with mixed germ-cell tumor of the testis. (19898219)
2009
12
Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving multiple lung metastases that was effectively treated with high-dose chemotherapy. (20057969)
2009
13
Testicular microlithiasis preceding metastatic mixed germ cell tumor--first pediatric report and recommended management of testicular microlithiasis in the pediatric population. (19100602)
2009
14
Bowel loop in an ovarian tumor: grossly visible, completely developed intestinal loop in mature cystic teratoma of malignant mixed germ cell tumor. (19563411)
2009
15
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
16
Mixed or non-seminomatous germ-cell tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up. (18456768)
2008
17
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. (18574668)
2008
18
Congenital cerebellar mixed germ cell tumor presenting with hemorrhage in a newborn. (18607121)
2008
19
Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature. (19197460)
2008
20
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. (18039910)
2007
21
Malignant ganglioneuroma arising from mediastinal mixed germ cell tumor. (17339149)
2007
22
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)
2007
23
Testicular mixed germ cell tumor in an adolescent with cowden disease. (18160807)
2007
24
Hypernatremic myopathy caused by a hypothalamic mixed germ cell tumor mimicking polymyositis. (17136312)
2007
25
Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving the maxillary gingiva. (16968241)
2006
26
Mixed nonseminomatous germ cell tumor presenting as a subcutaneous tissue mass. (17122498)
2006
27
Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report. (18095124)
2006
28
Testicular mixed germ cell tumor with polyembryoma component in brothers. (15803215)
2005
29
Best cases from the AFIP: bilateral testicular tumors: seminoma and mixed germ cell tumor. (15888629)
2005
30
Giant testicular mixed germ cell tumor. a case report. (14755145)
2004
31
Expression of CD34 antigen in testicular mixed germ cell tumor. (14629751)
2003
32
Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis. (14633619)
2003
33
Congenital mixed malignant germ cell tumor involving cerebrum and orbit. (12825484)
2003
34
Ascitic fluid and imprint cytology of mixed germ cell tumor of the ovary. (11843561)
2002
35
Growing teratoma syndrome after chemotherapy for a mixed germ cell tumor of the ovary. (12214834)
2002
36
Membranoproliferative glomerulonephritis associated with a mixed-cell germinal ovary tumor. (11275633)
2001
37
Mixed germ cell tumor of the ovary with sarcomatous component. (11349223)
2001
38
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. (10849320)
2000
39
Neuroradiology case of the day. Malignant mixed germ cell tumor with yolk sac and teratomatous components. (10336209)
1999
40
Gonadoblastoma, mixed germ cell tumor, and Y chromosomal genotype: molecular analysis in four patients. (10221338)
1999
41
Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor. (9865846)
1998
42
Mixed tumors of the pineal area. Diagnosis and therapy consisting of secreting germ cell tumor]. (9673977)
1998
43
Remission of recurrent mixed germ cell tumor of the ovary after treatment with vincristine, carboplatin, fluorouracil, and ifosfamide: a case report and review of the literature. (8933826)
1996
44
Mixed germ cell tumor of the basal ganglia: a case report. (8059329)
1994
45
Gonadal mixed germ cell tumor combined with a large hemangiomatous lesion in a patient with Turner's syndrome and 45,X/46,X, +mar karyotype. (7979900)
1994
46
A clinicopathologic, histologic, and immunohistochemical study of mixed germ cell-stromal tumors of the testis in 16 dogs. (8392765)
1993
47
Intracranial mixed germ cell tumor with syncytiotrophoblastic giant cells and precocious puberty. (2452550)
1988
48
Mixed germ cell tumor of the ovary with pure choriocarcinoma metastasis. (3016631)
1986
49
A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report. (2856468)
1986
50
Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor. (6195930)
1983

Genetic Variations for Mixed Germ Cell Tumor

Expression for genes affiliated with Mixed Germ Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Germ Cell Tumor

Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

Pathways for genes affiliated with Mixed Germ Cell Tumor

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Mixed Germ Cell Tumor

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1vitamin k2459.9ALPP, AFP
2ctp459.8CGB, CGA
3hydroxyflutamide45 2910.8ALPP, CGA
4oestriol459.7AFP, CGB, CGA
5clomiphene citrate459.7AFP, CGB, CGA
6ifosfamide45 1110.7AFP, CGB, CGA
7b 723459.7ALPP, AFP
8bleomycin45 1110.7AFP, CGB, CGA
9mifepristone45 60 29 1112.6CGA, CGB, AFP
10phenytoin45 50 29 1112.6ALPP, CGA
11folate459.4CGA, AFP, ALPP
12methotrexate45 50 1111.4CGA, CGB, AFP
13dmso459.4ALPP, AFP, CGA
14diethylstilbestrol45 29 1111.3PTEN, AFP, CGA
15thyroxine45 2410.2CGA, CGB, AFP, ALPP
16vincristine45 50 1111.2CGB, AFP, PTEN
17lactate459.1ALPP, AFP, CGB, CGA
18creatinine459.1ALPP, AFP, CGB, CGA
19cyclophosphamide45 50 1110.9CGA, CGB, AFP, PTEN
20norepinephrine45 11 2410.9CGA, POU5F1, ALPP
21etoposide45 50 60 1111.8CGA, CGB, AFP, PTEN
22estradiol45 11 2410.8CGA, CGB, AFP, PTEN
23vitamin d458.8ALPP, PTEN, AFP, CGA
24tamoxifen45 50 29 1111.8ALPP, PTEN, CGA
25paraffin458.7CGA, AFP, PTEN, ALPP
26progesterone45 60 29 11 2412.7CGA, CGB, AFP, PTEN
27aspartate458.7CGA, AFP, PTEN, ALPP
28doxorubicin45 50 1110.6PTEN, AFP, CGA
29h2o2458.6ALPP, PTEN, AFP, CGA
30cisplatin45 50 60 1111.4CGA, CGB, AFP, PTEN, ALPP
31testosterone45 60 11 2411.3CGA, CGB, AFP, PTEN, ALPP
32alanine458.3CGA, CGB, AFP, PTEN, ALPP
33retinoic acid45 249.0ALPP, PTEN, POU5F1, AFP, SOX2
34vegf457.7CGA, CGB, AFP, POU5F1, PTEN, ALPP

GO Terms for genes affiliated with Mixed Germ Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGB, CGA
2eye developmentGO:0016549.6GDF3, SOX2
3endodermal cell fate specificationGO:0017149.5POU5F1, SOX2
4negative regulation of organ growthGO:0466219.4PTEN, CGA
5somatic stem cell maintenanceGO:0350199.3SOX2, POU5F1
6response to woundingGO:0096119.3POU5F1, SOX2
7regulation of gene expressionGO:0104689.0POU5F1, SOX2
8negative regulation of epithelial cell proliferationGO:0506809.0PTEN, SOX2

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.3POU5F1, SOX2

Products for genes affiliated with Mixed Germ Cell Tumor

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Sources for Mixed Germ Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet