MCID: MXD032
MIFTS: 45

Mixed Germ Cell Tumor malady

Cancer diseases, Rare diseases categories
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Summaries for Mixed Germ Cell Tumor

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33MalaCards
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MalaCards: Mixed Germ Cell Tumor is related to choriocarcinoma and teratoma. An important gene associated with Mixed Germ Cell Tumor is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide hormone metabolism. The compounds ctp and vinblastine have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and pineal, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Mixed Germ Cell Tumor

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49Orphanet, 62UMLS, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Aliases & Descriptions:

mixed germ cell tumor 49 62


External Ids:

SNOMED-CT via Orphanet59 32844007
UMLS via Orphanet63 C0334524

Related Diseases for Mixed Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Mixed Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1choriocarcinoma31.0ALPP, CGB, AFP, CGA
2teratoma30.9CGB, SOX2, ALPP, CGA, POU5F1, AFP
3endodermal sinus tumor30.6ALPP, AFP, CGB
4gonadoblastoma30.6ALPP, POU5F1
5germinoma30.6ALPP, CGA, AFP, POU5F1, CGB
6dysgerminoma30.5AFP, POU5F1, ALPP, CGA
7cryptorchidism30.4CGA, ALPP
8seminoma30.1CGA, AFP, SOX2, POU5F1, ALPP, CGB
9germ cell tumors11.3
10polyembryoma10.6
11mature teratoma10.6
12mediastinitis10.5
13childhood testicular mixed germ cell tumor10.5
14adult central nervous system mixed germ cell tumor10.4
15childhood central nervous system mixed germ cell tumor10.4
16epithelioid trophoblastic tumor10.4
17pancreatitis10.4
18precocious puberty10.4
19testicular microlithiasis10.4
20mixed germ cell tumor of the central nervous system10.4
21growing teratoma syndrome10.4
22diabetes insipidus10.2
23cowden disease10.2
24microcystic meningioma10.2
25teratocarcinoma10.2
26ovarian gonadoblastoma10.2
27embryoma10.2
28ganglioneuroma10.2
29ovarian mixed germ cell neoplasm10.2
30smith-lemli-opitz syndrome10.2
31adenoma10.2
32craniopharyngioma10.2
33cystic teratoma10.2
34gonadal dysgenesis10.2
35hemangioblastoma10.2
36hemangioma10.2
37hemangiopericytoma10.2
38leukemia10.2
39meningioma10.2
40myopathy10.2
41neuroblastoma10.2
42pituitary adenoma10.2
43prostatitis10.2
44pseudohermaphroditism10.2
45rhabdomyosarcoma10.2
46polymyositis10.2
47extragonadal germ cell tumor10.1AFP
48oligohydramnios10.1AFP
49leydig cell tumor10.1CGA
50sertoli cell tumor10.1ALPP

Graphical network of the top 20 diseases related to Mixed Germ Cell Tumor:



Diseases related to mixed germ cell tumor

Symptoms for Mixed Germ Cell Tumor

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Drugs & Therapeutics for Mixed Germ Cell Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mixed Germ Cell Tumor

Search NIH Clinical Center for Mixed Germ Cell Tumor

Genetic Tests for Mixed Germ Cell Tumor

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Anatomical Context for Mixed Germ Cell Tumor

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33MalaCards
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MalaCards organs/tissues related to Mixed Germ Cell Tumor:

33
Ovary, Testis, Pineal, Pituitary, Skin, Brain, Cerebellum, Prostate, Heart, Eye, Lung, Kidney, Liver, Temporal lobe

Animal Models for Mixed Germ Cell Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mixed Germ Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CGA, SOX2, PTEN, AFP, GDF3
2MP:00053797.9AFP, PTEN, SOX2, POU5F1, CGA
3MP:00053807.6ALPP, POU5F1, SOX2, PTEN, GDF3
4MP:00028737.5GDF3, PTEN, SOX2, POU5F1, ALPP
5MP:00053787.5GDF3, PTEN, SOX2, ALPP, CGA
6MP:00053897.4CGA, ALPP, POU5F1, SOX2, PTEN, AFP
7MP:00107687.1GDF3, AFP, PTEN, SOX2, POU5F1, ALPP

Publications for Mixed Germ Cell Tumor

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52PubMed
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Articles related to Mixed Germ Cell Tumor:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Intratumoral hemorrhage because of primary spinal mixed germ cell tumor presenting with atypical radiological features in an adult. (23953732)
2013
2
Mixed germ cell tumor of mediastinum/lung masquerading as hemangioma in fine needle biopsy. (24056656)
2013
3
Mixed germ cell tumor complicating an intra-abdominal cryptorchidism. (24176649)
2013
4
Mixed germ cell tumor with extensive yolk sac tumor elements in the frontal lobe of an adult. (23326746)
2012
5
Extragonadal mixed germ cell tumor of the right arm: description of the first case in the literature. (22540884)
2012
6
Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. (21287366)
2011
7
Can stereotactic sample biopsies accurately diagnose mixed germ cell tumors? (21541683)
2011
8
Mixed germ cell tumor with embryonal carcinoma, choriocarcinoma, and epithelioid trophoblastic tumor in the ovary of a cynomolgus monkey. (21519041)
2011
9
Mixed germ cell tumor and hemangioblastoma in the cerebellum: report of a rare coexistence. (21442239)
2011
10
Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma. (19116786)
2011
11
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
12
Primary mixed germ cell tumor of the liver with sarcomatous components. (20128038)
2010
13
Mixed germ cell tumor metastatic to the skin: case report and literature review. (20331874)
2010
14
Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge. (19099195)
2009
15
Mixed germ cell tumor of the testicle with ravdomuosarcomatous component: a case report. (20062623)
2009
16
Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis. (18407327)
2009
17
Blunt testicular trauma results in rupture of mixed germ cell tumor. (20003680)
2009
18
Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass. (19201104)
2009
19
Metachronous gliomas following cranial irradiation for mixed germ cell tumors. (19247675)
2009
20
Mixed germ cell tumor of the midbrain. Case Report. (19645547)
2009
21
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. (19437819)
2008
22
Mixed germ cell tumors in septum pellucidum after radiochemotherapy of suprasellar germinoma: de novo metachronous or recurrent neoplasms? (18560841)
2008
23
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report. (18574668)
2008
24
Congenital cerebellar mixed germ cell tumor presenting with hemorrhage in a newborn. (18607121)
2008
25
Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature. (19197460)
2008
26
Malignant ganglioneuroma arising from mediastinal mixed germ cell tumor. (17339149)
2007
27
Testicular mixed germ cell tumor in an adolescent with cowden disease. (18160807)
2007
28
Twisted mixed germ cell tumor of the ovary in a child. (16883461)
2006
29
Different transformation of mature teratoma in a patient with mixed germ cell tumor of the testis. (15985085)
2005
30
Giant testicular mixed germ cell tumor. a case report. (14755145)
2004
31
Expression of CD34 antigen in testicular mixed germ cell tumor. (14629751)
2003
32
Dysgerminoma with a slightly elevated alpha-fetoprotein level diagnosed as a mixed germ cell tumor after recurrence. (12624554)
2003
33
Pelvic hemangiopericytoma in a patient with mixed germ cell tumor of the testis. (11586234)
2001
34
Cardiac metastasis from testicular mixed germ cell tumor. (11594415)
2001
35
Retroperitoneal mature teratoma 15 years after initial treatment of testicular mixed germ cell tumor. (11096252)
2000
36
An adult patient with a mixed germ cell tumor of the spermatic cord. (10754174)
2000
37
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. (10849320)
2000
38
Ovarian mixed germ cell tumor composed of endodermal sinus tumor and immature teratoma: case report. (10968342)
2000
39
Intrarenal mixed germ cell tumor. (11061908)
2000
40
Mixed germ cell tumor of the testicle presenting with a sacrococcygeal mass and no evidence of retroperitoneal adenopathy. (10379766)
1999
41
Neuroradiology case of the day. Malignant mixed germ cell tumor with yolk sac and teratomatous components. (10336209)
1999
42
Microcystic meningioma arising in a mixed germ cell tumor of the testis: a case report. (10478675)
1999
43
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. (9648599)
1998
44
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. (9605457)
1998
45
Late seminomatous relapse of a mixed germ cell tumor of the testis on intensive surveillance. (7853562)
1995
46
Neuroblastoma as a prominent component of a mixed germ cell tumor of testis. (8242553)
1993
47
Mixed germ cell tumor of the ovary with a prominent polyembryoma component. (1848837)
1991
48
Associated leukemia and mixed germ cell tumor in a patient with gonadal dysgenesis. (1680081)
1991
49
Intrasellar mixed germ-cell tumor. Case report. (6834126)
1983
50
Serum alphafetoprotein (AFP) in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. (75054)
1978

Variations for Mixed Germ Cell Tumor

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Expression for genes affiliated with Mixed Germ Cell Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Germ Cell Tumor

Search GEO for disease gene expression data for Mixed Germ Cell Tumor.

Pathways for genes affiliated with Mixed Germ Cell Tumor

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 5Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Mixed Germ Cell Tumor

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1ctp4510.0CGB, CGA
2vinblastine45 51 1112.0AFP, CGA
3vitamin k24510.0ALPP, AFP
4hydroxyflutamide45 2910.9CGA, ALPP
5b 723459.9ALPP, AFP
6vitamin b12459.9AFP, ALPP
7phenytoin45 51 29 1112.9ALPP, CGA
8androstenedione45 2410.8CGA, CGB
9oestriol459.8CGA, CGB, AFP
10clomiphene citrate459.8CGA, CGB, AFP
11ifosfamide45 1110.8CGA, CGB, AFP
12carboplatin45 51 1111.8AFP, CGA
13bleomycin45 1110.7CGA, CGB, AFP
14mifepristone45 29 61 1112.7CGA, CGB, AFP
15progestin459.7CGA, ALPP
16methotrexate51 45 1111.7CGA, CGB, AFP
17folate459.6AFP, ALPP, CGA
18dmso459.6CGA, ALPP, AFP
19polyethylene glycol459.5ALPP, AFP
20heparin45 29 24 1112.5CGA, ALPP, AFP
21diethylstilbestrol45 29 1111.4AFP, PTEN, CGA
22latex459.3ALPP, AFP
23vincristine45 51 1111.3CGB, PTEN, AFP
24thyroxine45 2410.3AFP, ALPP, CGB, CGA
25norepinephrine45 24 1111.3POU5F1, ALPP, CGA
26doxorubicin45 51 1111.2CGA, PTEN, AFP
27lactate459.2AFP, ALPP, CGB, CGA
28creatinine459.2AFP, ALPP, CGB, CGA
29tamoxifen45 51 29 1112.1PTEN, ALPP, CGA
30cyclic amp45 2410.1CGA, CGB, PTEN
31pge2459.0CGA, ALPP, PTEN
32cyclophosphamide45 51 1111.0CGA, CGB, PTEN, AFP
33etoposide45 51 61 1112.0AFP, PTEN, CGB, CGA
34cycloheximide458.9PTEN, ALPP, CGA
35estradiol45 24 1110.9AFP, PTEN, CGB, CGA
36progesterone45 29 61 24 1112.9AFP, PTEN, CGB, CGA
37vitamin d458.8AFP, PTEN, ALPP, CGA
38paraffin458.8AFP, PTEN, ALPP, CGA
39aspartate458.8AFP, PTEN, ALPP, CGA
40cholesterol45 29 24 1111.8ALPP, PTEN, AFP
41h2o2458.8CGA, ALPP, PTEN, AFP
42serine458.5AFP, PTEN, ALPP, CGA
43cisplatin45 51 61 1111.4AFP, PTEN, ALPP, CGB, CGA
44testosterone45 61 24 1111.4AFP, PTEN, ALPP, CGB, CGA
45alanine458.4CGA, CGB, ALPP, PTEN, AFP
46estrogen458.4AFP, PTEN, ALPP, CGB, CGA
47retinoic acid45 249.1ALPP, POU5F1, SOX2, PTEN, AFP
48vegf457.8AFP, PTEN, POU5F1, ALPP, CGB, CGA

GO Terms for genes affiliated with Mixed Germ Cell Tumor

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16Gene Ontology
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Biological processes related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.8CGA, CGB
2eye developmentGO:0016549.6SOX2, GDF3
3endodermal cell fate specificationGO:0017149.5POU5F1, SOX2
4negative regulation of organ growthGO:0466219.4CGA, PTEN
5somatic stem cell maintenanceGO:0350199.3SOX2, POU5F1
6regulation of gene expressionGO:0104689.3POU5F1, SOX2
7response to woundingGO:0096119.0POU5F1, SOX2
8negative regulation of epithelial cell proliferationGO:0506809.0SOX2, PTEN

Molecular functions related to Mixed Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7CGA, CGB
2miRNA bindingGO:0351989.0POU5F1, SOX2

Products for genes affiliated with Mixed Germ Cell Tumor

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Sources for Mixed Germ Cell Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet