MCID: MXD026
MIFTS: 42

Mixed Glioma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Mixed Glioma

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MalaCards based summary: Mixed Glioma, also known as mixed neuroglial tumor, is related to oligodendroglioma and anaplastic oligodendroglioma. An important gene associated with Mixed Glioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoplasmic microtubules. The compounds pentobarbital and phenylbutyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and endothelial, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Mixed Glioma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Mixed Glioma, Aliases & Descriptions:

Name: Mixed Glioma 8 10 44
Mixed Neuroglial Tumor 8 62
 
Mixed Gliomas 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:5076
NCIt39 C3903
SNOMED-CT57 443937008, 22217002
MeSH34 D005910

Related Diseases for Mixed Glioma

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Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma30.7PDGFRA, GFAP
2anaplastic oligodendroglioma30.4GFAP, PDGFRA
3glioblastoma multiforme30.3GFAP, PDGFRA
4rhabdomyosarcoma30.2PDGFRA, VIM
5astrocytoma30.0PDGFRA, VIM, GFAP
6sarcoma29.8PDGFRA, VIM, HSPA4
7neurilemmoma10.4GFAP
8syringoma10.4GFAP
9choroid plexus papilloma10.4GFAP
10subependymal giant cell astrocytoma10.4GFAP
11giant cell glioblastoma10.4GFAP
12perineurioma10.4VIM
13adult brainstem mixed glioma10.4
14oligoastrocytoma10.3
15rhabdoid meningioma10.2GFAP, VIM
16astroblastoma10.2VIM, GFAP
17myoepithelioma10.2GFAP, VIM
18cataract10.2HSPA4
19mixed oligodendroglioma-astrocytoma10.2
20pleomorphic adenoma10.2VIM, GFAP
21endometrial stromal sarcoma10.2PDGFRA, VIM
22tuberous sclerosis10.2GFAP, VIM
23grade iii astrocytoma10.2GFAP, PDGFRA
24angiosarcoma10.2VIM, PDGFRA
25malignant peripheral nerve sheath tumor10.2VIM, PDGFRA
26neurofibroma10.2PDGFRA, VIM
27gastrointestinal stromal tumor10.2PDGFRA, VIM
28leiomyosarcoma10.2PDGFRA, VIM
29leiomyoma10.1PDGFRA, VIM
30peripheral primitive neuroectodermal tumor10.1PDGFRA, VIM
31chondrosarcoma10.1VIM, PDGFRA
32meningioma10.1GFAP, VIM
33medulloblastoma10.1PDGFRA, GFAP
34charcot-marie-tooth disease10.1
35multiple sclerosis10.1
36germinoma10.1
37tooth disease10.1
38anaplastic oligoastrocytoma10.1
39glioblastoma10.1
40endotheliitis10.1
41toxic encephalopathy10.0HSPA4, GFAP
42prion disease10.0GFAP, HSPA4
43fibrosarcoma10.0PDGFRA, VIM
44chordoma10.0PDGFRA, VIM, GFAP
45ependymoma10.0GFAP, VIM, PDGFRA
46malignant glioma9.9PDGFRA, GFAP
47dementia9.9GFAP, HSPA4
48chronic myeloid leukemia9.9PDGFRA, HSPA4
49vascular disease9.9HSPA4, GFAP
50tongue squamous cell carcinoma9.8PDGFRA, VIM, HSPA4

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to mixed glioma

Symptoms for Mixed Glioma

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Drugs & Therapeutics for Mixed Glioma

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Drug clinical trials:

Search ClinicalTrials for Mixed Glioma

Search NIH Clinical Center for Mixed Glioma

Genetic Tests for Mixed Glioma

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Anatomical Context for Mixed Glioma

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MalaCards organs/tissues related to Mixed Glioma:

32
Brain, Cerebellum, Endothelial

Animal Models for Mixed Glioma or affiliated genes

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MGI Mouse Phenotypes related to Mixed Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1GFAP, VIM, PDGFRA, HRC
2MP:00053858.1GFAP, VIM, PDGFRA, HRC
3MP:00053788.1HRC, PDGFRA, VIM, GFAP
4MP:00053848.1PDGFRA, VIM, HSPA4, GFAP
5MP:00036317.9GFAP, HSPA4, VIM, PDGFRA
6MP:00053867.6HRC, PDGFRA, VIM, HSPA4, GFAP

Publications for Mixed Glioma

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Articles related to Mixed Glioma:

(show all 13)
idTitleAuthorsYear
1
Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? (25359109)
2014
2
Mixed Glioma (Oligoastrocytoma) in the Brain ofA an African Hedgehog (Atelerix albiventris). (25172052)
2014
3
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. (17252186)
2007
4
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. (12889176)
2003
5
Long-term outcome of low-grade oligodendroglioma and mixed glioma. (10751254)
2000
6
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. (9524101)
1998
7
Exophytic malignant brainstem mixed glioma in an adult: a case report. (9524090)
1998
8
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. (3748360)
1986
9
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. (3713193)
1986
10
Mixed glioma of the cerebellopontine angle. (3878094)
1985
11
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. (6286891)
1982
12
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. (929897)
1977
13
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. (5050901)
1972

Variations for Mixed Glioma

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Expression for genes affiliated with Mixed Glioma

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Expression patterns in normal tissues for genes affiliated with Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for genes affiliated with Mixed Glioma

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Pathways related to Mixed Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2GFAP, VIM
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2VIM, GFAP
3
Show member pathways
8.7PDGFRA, VIM, GFAP
4
Show member pathways
8.6PDGFRA, VIM, HSPA4

Compounds for genes affiliated with Mixed Glioma

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Compounds related to Mixed Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1pentobarbital44 1110.9HSPA4, GFAP
2phenylbutyrate449.9GFAP, HSPA4
3silver449.8HSPA4, GFAP
4kainate44 2810.7HSPA4, GFAP
5eosin449.6VIM, GFAP
6s 100449.6VIM, GFAP
7reticulin449.6GFAP, VIM
8retinaldehyde449.6VIM, GFAP
9silicone449.6GFAP, VIM
10streptozotocin449.5VIM, GFAP
11hematoxylin449.5GFAP, VIM
12ganciclovir44 1110.5VIM, GFAP
13inositol449.5HSPA4, GFAP
14ganglioside449.5GFAP, VIM
15dbc-amp449.5VIM, GFAP
16chondroitin sulfate44 2410.4VIM, GFAP
17nocodazole44 1110.4VIM, HSPA4
18cytarabine44 50 1111.3VIM, GFAP
19adriamycin449.2VIM, HSPA4
20neomycin449.1VIM, HSPA4, GFAP
21cocaine44 1110.1VIM, HSPA4, GFAP
22bromodeoxyuridine449.1GFAP, HSPA4, VIM
23isoproterenol44 1110.1GFAP, HSPA4, VIM
24agar449.1VIM, HSPA4, GFAP
255-hydroxytryptamine449.1VIM, GFAP
26butyrate449.1GFAP, HSPA4, VIM
27methionine449.1VIM, HSPA4, GFAP
28nmda44 2810.1VIM, HSPA4, GFAP
29paclitaxel44 50 1111.1VIM, HSPA4, GFAP
30acetylcholine44 50 28 24 1113.1VIM, HSPA4, GFAP
31estradiol44 24 1111.1VIM, HSPA4, GFAP
32genistein44 28 61 2 24 1114.1GFAP, HSPA4, VIM
33glutamine449.0VIM, HSPA4, GFAP
34iron44 2410.0VIM, HSPA4, GFAP
35lactate449.0GFAP, HSPA4, VIM
36creatinine449.0VIM, HSPA4, GFAP
37adenylate449.0GFAP, HSPA4, VIM
38cycloheximide449.0VIM, HSPA4, GFAP
39progesterone44 28 61 24 1113.0VIM, HSPA4, GFAP
40testosterone44 61 24 1112.0VIM, HSPA4, GFAP
41dexamethasone44 50 28 1111.9GFAP, HSPA4, VIM
42glutamate448.9GFAP, HSPA4, VIM
43tgf beta1448.8PDGFRA, VIM
44alanine448.8VIM, HSPA4, GFAP
45estrogen448.7GFAP, VIM, PDGFRA
46paraffin448.6PDGFRA, VIM, HSPA4, GFAP
47aspartate448.6GFAP, HSPA4, VIM, PDGFRA
48vegf448.6PDGFRA, VIM, HSPA4, GFAP
49retinoic acid44 249.6PDGFRA, VIM, HSPA4, GFAP
50atp44 289.6GFAP, HSPA4, VIM, PDGFRA

GO Terms for genes affiliated with Mixed Glioma

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Cellular components related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.2VIM, GFAP

Biological processes related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.2VIM, GFAP
2negative regulation of neuron projection developmentGO:0109779.2VIM, GFAP
3astrocyte developmentGO:0140029.1VIM, GFAP
4intermediate filament organizationGO:0451098.9VIM, GFAP

Molecular functions related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2VIM, GFAP

Products for genes affiliated with Mixed Glioma

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  • Proteins
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Sources for Mixed Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet