MCID: MXD026
MIFTS: 41

Mixed Glioma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Mixed Glioma

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33MalaCards
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MalaCards: Mixed Glioma, also known as mixed gliomas, is related to oligodendroglioma and anaplastic oligodendroglioma. An important gene associated with Mixed Glioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoplasmic microtubules. The compounds pentobarbital and phenylbutyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and endothelial, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Mixed Glioma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

mixed glioma 8 10 45
mixed gliomas 8 62
mixed neuroglial tumor 8


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Disease Ontology8 DOID:5076
NCIt40 C3903
SNOMED-CT58 443937008, 22217002
MeSH35 D005910

Related Diseases for Mixed Glioma

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17GeneCards, 18GeneDecks
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Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma30.3PDGFRA, GFAP
2anaplastic oligodendroglioma30.1GFAP, PDGFRA
3glioblastoma multiforme30.1GFAP, PDGFRA
4rhabdomyosarcoma30.1PDGFRA, VIM
5sarcoma30.0PDGFRA, VIM, HSPA4
6adult brainstem mixed glioma10.3
7oligoastrocytoma10.2
8neurilemmoma10.1GFAP
9syringoma10.1GFAP
10choroid plexus papilloma10.1GFAP
11subependymal giant cell astrocytoma10.1GFAP
12giant cell glioblastoma10.1GFAP
13perineurioma10.1VIM
14rhabdoid meningioma10.1GFAP, VIM
15astroblastoma10.1VIM, GFAP
16myoepithelioma10.0GFAP, VIM
17cataract10.0HSPA4
18pleomorphic adenoma10.0VIM, GFAP
19endometrial stromal sarcoma10.0PDGFRA, VIM
20mixed oligodendroglioma-astrocytoma10.0
21charcot-marie-tooth disease10.0
22multiple sclerosis10.0
23tooth disease10.0
24anaplastic oligoastrocytoma10.0
25germinoma10.0
26endotheliitis10.0
27tuberous sclerosis10.0GFAP, VIM
28anaplastic astrocytoma10.0GFAP, PDGFRA
29angiosarcoma10.0VIM, PDGFRA
30malignant peripheral nerve sheath tumor10.0VIM, PDGFRA
31neurofibroma10.0PDGFRA, VIM
32gastrointestinal stromal tumor10.0PDGFRA, VIM
33leiomyosarcoma10.0PDGFRA, VIM
34leiomyoma10.0PDGFRA, VIM
35peripheral primitive neuroectodermal tumor10.0PDGFRA, VIM
36chondrosarcoma10.0VIM, PDGFRA
37meningioma10.0GFAP, VIM
38medulloblastoma10.0PDGFRA, GFAP
39toxic encephalopathy10.0HSPA4, GFAP
40prion disease10.0GFAP, HSPA4
41fibrosarcoma10.0PDGFRA, VIM
42chordoma10.0PDGFRA, VIM, GFAP
43ependymoma10.0GFAP, VIM, PDGFRA
44astrocytoma10.0PDGFRA, VIM, GFAP
45dementia10.0GFAP, HSPA4
46malignant glioma10.0PDGFRA, GFAP
47chronic myeloid leukemia10.0PDGFRA, HSPA4
48vascular disease10.0HSPA4, GFAP
49tongue squamous cell carcinoma9.9PDGFRA, VIM, HSPA4
50melanoma9.9PDGFRA, VIM, HSPA4

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to mixed glioma

Symptoms for Mixed Glioma

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Drugs & Therapeutics for Mixed Glioma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Mixed Glioma

Genetic Tests for Mixed Glioma

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Anatomical Context for Mixed Glioma

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33MalaCards
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MalaCards organs/tissues related to Mixed Glioma:

33
Brain, Cerebellum, Endothelial

Animal Models for Mixed Glioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mixed Glioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1GFAP, VIM, PDGFRA, HRC
2MP:00053858.1GFAP, VIM, PDGFRA, HRC
3MP:00053788.1HRC, PDGFRA, VIM, GFAP
4MP:00053848.1PDGFRA, VIM, HSPA4, GFAP
5MP:00036317.9GFAP, HSPA4, VIM, PDGFRA
6MP:00053867.6HRC, PDGFRA, VIM, HSPA4, GFAP

Publications for Mixed Glioma

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52PubMed
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Articles related to Mixed Glioma:

(show all 11)
idTitleAuthorsYear
1
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. (17252186)
2007
2
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. (12889176)
2003
3
Long-term outcome of low-grade oligodendroglioma and mixed glioma. (10751254)
2000
4
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. (9524101)
1998
5
Exophytic malignant brainstem mixed glioma in an adult: a case report. (9524090)
1998
6
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. (3748360)
1986
7
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. (3713193)
1986
8
Mixed glioma of the cerebellopontine angle. (3878094)
1985
9
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. (6286891)
1982
10
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. (929897)
1977
11
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. (5050901)
1972

Variations for Mixed Glioma

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Expression for genes affiliated with Mixed Glioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for genes affiliated with Mixed Glioma

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Sources:
50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 60Thomson Reuters, 53QIAGEN
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Pathways related to Mixed Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2GFAP, VIM
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.2VIM, GFAP
3
Show member pathways
8.7PDGFRA, VIM, GFAP
4
Show member pathways
8.6PDGFRA, VIM, HSPA4

Compounds for genes affiliated with Mixed Glioma

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Mixed Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1pentobarbital45 1110.9HSPA4, GFAP
2phenylbutyrate459.9GFAP, HSPA4
3silver459.8HSPA4, GFAP
4kainate45 2910.7HSPA4, GFAP
5eosin459.6VIM, GFAP
6s 100459.6VIM, GFAP
7reticulin459.6GFAP, VIM
8retinaldehyde459.6VIM, GFAP
9silicone459.6GFAP, VIM
10streptozotocin459.5VIM, GFAP
11hematoxylin459.5GFAP, VIM
12ganciclovir45 1110.5VIM, GFAP
13inositol459.5HSPA4, GFAP
14ganglioside459.5GFAP, VIM
15dbc-amp459.5VIM, GFAP
16chondroitin sulfate45 2410.4VIM, GFAP
17nocodazole45 1110.4VIM, HSPA4
18cytarabine45 51 1111.3VIM, GFAP
19adriamycin459.2VIM, HSPA4
20neomycin459.1VIM, HSPA4, GFAP
21cocaine45 1110.1VIM, HSPA4, GFAP
22bromodeoxyuridine459.1GFAP, HSPA4, VIM
23isoproterenol45 1110.1GFAP, HSPA4, VIM
24agar459.1VIM, HSPA4, GFAP
255-hydroxytryptamine459.1VIM, GFAP
26butyrate459.1GFAP, HSPA4, VIM
27methionine459.1VIM, HSPA4, GFAP
28nmda45 2910.1VIM, HSPA4, GFAP
29paclitaxel45 51 1111.1VIM, HSPA4, GFAP
30acetylcholine45 51 29 24 1113.1VIM, HSPA4, GFAP
31estradiol45 24 1111.1VIM, HSPA4, GFAP
32genistein45 29 61 3 24 1114.1GFAP, HSPA4, VIM
33glutamine459.0VIM, HSPA4, GFAP
34iron45 2410.0VIM, HSPA4, GFAP
35lactate459.0GFAP, HSPA4, VIM
36creatinine459.0VIM, HSPA4, GFAP
37adenylate459.0GFAP, HSPA4, VIM
38cycloheximide459.0VIM, HSPA4, GFAP
39progesterone45 29 61 24 1113.0VIM, HSPA4, GFAP
40testosterone45 61 24 1112.0VIM, HSPA4, GFAP
41dexamethasone45 51 29 1111.9GFAP, HSPA4, VIM
42glutamate458.9GFAP, HSPA4, VIM
43tgf beta1458.8PDGFRA, VIM
44alanine458.8VIM, HSPA4, GFAP
45estrogen458.7GFAP, VIM, PDGFRA
46paraffin458.6PDGFRA, VIM, HSPA4, GFAP
47aspartate458.6GFAP, HSPA4, VIM, PDGFRA
48vegf458.6PDGFRA, VIM, HSPA4, GFAP
49retinoic acid45 249.6PDGFRA, VIM, HSPA4, GFAP
50atp45 299.6GFAP, HSPA4, VIM, PDGFRA

GO Terms for genes affiliated with Mixed Glioma

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16Gene Ontology
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Cellular components related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.2VIM, GFAP

Biological processes related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.2VIM, GFAP
2negative regulation of neuron projection developmentGO:0109779.2VIM, GFAP
3astrocyte developmentGO:0140029.1VIM, GFAP
4intermediate filament organizationGO:0451098.9VIM, GFAP

Molecular functions related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2VIM, GFAP

Products for genes affiliated with Mixed Glioma

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Sources for Mixed Glioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet