MCID: MXD026
MIFTS: 35

Mixed Glioma

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Mixed Glioma

MalaCards integrated aliases for Mixed Glioma:

Name: Mixed Glioma 12 51 14
Mixed Gliomas 12 69
Mixed Neuroglial Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5076
MeSH 41 D005910
NCIt 46 C3903
SNOMED-CT 64 22217002 443937008
UMLS 69 C0259783

Summaries for Mixed Glioma

MalaCards based summary : Mixed Glioma, also known as mixed gliomas, is related to glioma and glioma susceptibility 1. An important gene associated with Mixed Glioma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Central carbon metabolism in cancer. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells.

Related Diseases for Mixed Glioma

Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 glioma 30.1 IDH1 PDGFRA TP53
2 glioma susceptibility 1 29.7 IDH1 TP53
3 astrocytoma 29.3 GFAP IDH1 TP53
4 oligodendroglioma 29.3 GFAP IDH1 PDGFRA TP53
5 glioblastoma 29.2 IDH1 PDGFRA TP53
6 glioblastoma multiforme 28.9 GFAP IDH1 PDGFRA TP53
7 adult brainstem mixed glioma 12.1
8 oligoastrocytoma 11.5
9 anaplastic oligoastrocytoma 11.0
10 mixed oligodendroglioma-astrocytoma 11.0
11 frontal convexity meningioma 10.4 GFAP TP53
12 gliofibroma 10.4 GFAP TP53
13 cerebral convexity meningioma 10.4 GFAP TP53
14 protoplasmic astrocytoma 10.4 GFAP TP53
15 cellular ependymoma 10.4 GFAP TP53
16 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP TP53
17 cerebral neuroblastoma 10.4 GFAP TP53
18 spinal cancer 10.4 GFAP TP53
19 chordoid glioma 10.4 GFAP TP53
20 ependymoblastoma 10.4 GFAP TP53
21 cerebral ventricle cancer 10.4 GFAP TP53
22 cerebrum cancer 10.4 GFAP TP53
23 supratentorial cancer 10.4 GFAP TP53
24 malignant ependymoma 10.3 GFAP TP53
25 papilloma of choroid plexus 10.3 GFAP TP53
26 choroid plexus cancer 10.3 GFAP TP53
27 necrotizing sialometaplasia 10.3 GFAP TP53
28 cystic teratoma 10.3 GFAP TP53
29 cerebellar liponeurocytoma 10.3 GFAP TP53
30 medullomyoblastoma 10.3 GFAP TP53
31 juvenile pilocytic astrocytoma 10.3 GFAP TP53
32 brain glioma 10.3 GFAP TP53
33 clear cell ependymoma 10.3 GFAP TP53
34 optic nerve glioma 10.3 GFAP TP53
35 ganglioglioma 10.3 GFAP TP53
36 breast malignant phyllodes tumor 10.2 AGO2 TP53
37 infratentorial cancer 10.2 GFAP TP53
38 extraventricular neurocytoma 10.2 GFAP IDH1
39 chordoma 10.2 GFAP PDGFRA
40 intracranial chondrosarcoma 10.2 IDH1 TP53
41 dysembryoplastic neuroepithelial tumor 10.2 GFAP IDH1
42 cerebellar astrocytoma 10.2 IDH1 TP53
43 neurilemmoma 10.2 GFAP PDGFRA
44 angiocentric glioma 10.2 GFAP IDH1
45 adenosquamous carcinoma 10.2 PDGFRA TP53
46 pleomorphic adenoma 10.2 GFAP TP53
47 childhood oligodendroglioma 10.2 GFAP IDH1
48 periosteal osteogenic sarcoma 10.1 IDH1 TP53
49 small cell carcinoma 10.1 PDGFRA TP53
50 cerebellopontine angle tumor 10.1 GFAP IDH1

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to Mixed Glioma

Symptoms & Phenotypes for Mixed Glioma

Drugs & Therapeutics for Mixed Glioma

Drugs for Mixed Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
3
Carmustine Approved, Investigational Phase 3,Phase 2,Phase 1 154-93-8 2578
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Vincristine Approved, Investigational Phase 3,Phase 1 2068-78-2, 57-22-7 5978
6
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
7
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
8
Procarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 671-16-9 4915
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
11
Lomustine Approved, Investigational Phase 3,Phase 1 13010-47-4 3950
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
13
Trioxsalen Approved Phase 3,Phase 2,Phase 1 3902-71-4 5585
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Methylphenidate Approved, Investigational Phase 3 20748-11-2, 113-45-1 4158
16
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5282379 5538
17
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538
18 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
19 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Ether Phase 3,Phase 2,Phase 1
21 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3
22 Analgesics Phase 3,Phase 2,Phase 1
23 Central Nervous System Depressants Phase 3,Phase 2
24 Adjuvants, Anesthesia Phase 3
25 Central Nervous System Stimulants Phase 3,Phase 2
26 Cholinergic Agents Phase 3,Phase 2
27 Narcotics Phase 3
28 Cholinesterase Inhibitors Phase 3,Phase 2
29 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
30 Neurotransmitter Agents Phase 3,Phase 2
31 Hematoporphyrin Derivative Phase 3,Phase 2,Phase 1
32 Hematoporphyrins Phase 3,Phase 2,Phase 1
33 Analgesics, Opioid Phase 3
34 Nootropic Agents Phase 3,Phase 2
35 Anesthetics Phase 3
36 Dermatologic Agents Phase 3,Phase 2,Phase 1
37 Anesthetics, General Phase 3
38 Anesthetics, Inhalation Phase 3
39 Anesthetics, Intravenous Phase 3
40 Dihematoporphyrin Ether Phase 3,Phase 2,Phase 1
41 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
42 Emetics Phase 3,Phase 2
43 Antiemetics Phase 3,Phase 2,Phase 1
44 Photosensitizing Agents Phase 3,Phase 2,Phase 1
45 Antimitotic Agents Phase 3,Phase 1
46 Liver Extracts Phase 3,Phase 2,Phase 1
47 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
48 BB 1101 Phase 3,Phase 2,Phase 1
49 Autonomic Agents Phase 3,Phase 1
50 Dopamine Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 183)

# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
2 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3 temozolomide
3 Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
4 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3 porfimer sodium
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
7 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
8 Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
9 Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas Active, not recruiting NCT00004259 Phase 3 BCNU 80mg/m2;TMZ 200mg/m2;CCNU;BCNU 150mg/m2;BCNU 200mg/m2;TMZ 150mg/m2 six 6-week cycles;TMZ 150mg/m2 six 8-week cycles
10 Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00978458 Phase 3 temozolomide
11 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
12 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
13 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
14 Temozolomide and Carmustine in Treating Patients With Anaplastic Glioma Unknown status NCT00003176 Phase 2 carmustine;temozolomide
15 Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Mixed Gliomas Completed NCT00003473 Phase 2 Atengenal;Astugenal
16 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy Completed NCT00004868 Phase 1, Phase 2 semaxanib
17 Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma Completed NCT00400816 Phase 2 temozolomide
18 Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors Completed NCT00003731 Phase 2 temozolomide
19 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
20 Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse Completed NCT00003775 Phase 2 leflunomide
21 Topotecan in Treating Patients With Recurrent Brain Tumors Completed NCT00003372 Phase 2 topotecan hydrochloride
22 Temozolomide, Thalidomide, and Celecoxib Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00047294 Phase 2 celecoxib;temozolomide;thalidomide
23 Fenretinide in Treating Patients With Recurrent Malignant Glioma Completed NCT00006080 Phase 2 fenretinide
24 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2 temozolomide
25 Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma Completed NCT00058123 Phase 2 poly ICLC
26 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
27 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
28 Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Completed NCT01462695 Phase 2 Sunitinib Malate
29 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
30 Sunitinib in Treating Patients With Recurrent Malignant Gliomas Completed NCT00499473 Phase 2 sunitinib malate
31 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
32 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
33 Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma Completed NCT00124657 Phase 1, Phase 2 Erlotinib hydrochloride
34 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
35 Temozolomide in Treating Patients With Recurrent High-Grade Glioma Completed NCT00619112 Phase 2 temozolomide
36 Carmustine Plus O6-benzylguanine in Treating Patients With Recurrent or Progressive Glioma Completed NCT00005081 Phase 2 O6-benzylguanine;carmustine
37 Immunotoxin Therapy in Treating Patients With Malignant Glioma Completed NCT00006268 Phase 1, Phase 2 isolated perfusion
38 Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) With Bevacizumab and Irinotecan for Malignant Glioma Completed NCT00352521 Phase 2 bevacizumab;irinotecan
39 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
40 ATN-161 and Carboplatin in Treating Patients With Recurrent Malignant Glioma Completed NCT00352313 Phase 1, Phase 2 ATN-161;carboplatin
41 Study of Capecitabine to Treat Recurrent High Grade Gliomas Completed NCT00717197 Phase 2 Capecitabine
42 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
43 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
44 Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma Completed NCT00795665 Phase 2 bevacizumab;carmustine
45 Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma Completed NCT00047281 Phase 2 celecoxib;cyclophosphamide;etoposide;thalidomide
46 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
47 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
48 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
49 Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma Completed NCT00301873 Phase 2 IV Zometa
50 Suramin in Treating Patients With Recurrent Primary Brain Tumors Completed NCT00002639 Phase 2 chemotherapy;suramin

Search NIH Clinical Center for Mixed Glioma

Genetic Tests for Mixed Glioma

Anatomical Context for Mixed Glioma

MalaCards organs/tissues related to Mixed Glioma:

38
Brain, Bone, T Cells, Bone Marrow, Liver, Spinal Cord, Endothelial

Publications for Mixed Glioma

Articles related to Mixed Glioma:

(show all 13)
# Title Authors Year
1
Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? ( 25359109 )
2014
2
Mixed Glioma (Oligoastrocytoma) in the Brain ofA an African Hedgehog (Atelerix albiventris). ( 25172052 )
2014
3
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. ( 17252186 )
2007
4
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. ( 12889176 )
2003
5
Long-term outcome of low-grade oligodendroglioma and mixed glioma. ( 10751254 )
2000
6
Exophytic malignant brainstem mixed glioma in an adult: a case report. ( 9524090 )
1998
7
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. ( 9524101 )
1998
8
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. ( 3713193 )
1986
9
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. ( 3748360 )
1986
10
Mixed glioma of the cerebellopontine angle. ( 3878094 )
1985
11
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. ( 6286891 )
1982
12
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. ( 929897 )
1977
13
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. ( 5050901 )
1972

Variations for Mixed Glioma

Expression for Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for Mixed Glioma

Pathways related to Mixed Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 PDGFRA TP53
2 10.61 IDH1 PDGFRA TP53

GO Terms for Mixed Glioma

Biological processes related to Mixed Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to reactive oxygen species GO:0034614 8.62 PDGFRA TP53

Sources for Mixed Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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