MCID: MXD026
MIFTS: 31

Mixed Glioma malady

Summaries for Mixed Glioma

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33MalaCards
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MalaCards: Mixed Glioma, also known as mixed gliomas, is related to anaplastic oligodendroglioma and adult brainstem mixed glioma. An important gene associated with Mixed Glioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Nanog in Mammalian ESC Pluripotency. The compounds glutamine and pentobarbital have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and muscle.

Aliases & Classifications for Mixed Glioma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

mixed glioma 8 10 45
mixed gliomas 8 61
mixed neuroglial tumor 8


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Disease Ontology8 DOID:5076
NCIt40 C3903
SNOMED-CT57 22217002, 443937008
MeSH35 D005910

Related Diseases for Mixed Glioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic oligodendroglioma30.0GFAP, PDGFRA
2adult brainstem mixed glioma10.4
3brain glioma10.2
4oligoastrocytoma10.2
5mixed oligodendroglioma-astrocytoma10.0
6tooth disease10.0
7anaplastic oligoastrocytoma10.0
8germinoma10.0
9gliosarcoma10.0GFAP
10giant cell glioblastoma10.0GFAP
11neurilemmoma10.0GFAP
12choroid plexus papilloma10.0GFAP
13subependymal giant cell astrocytoma10.0GFAP
14syringoma10.0GFAP
15clear cell ependymoma10.0VIM
16neurofibromatosis10.0PDGFRA
17perineurioma10.0VIM
18hemangioblastoma10.0GFAP
19brain cancer10.0GFAP
20dermatofibrosarcoma protuberans10.0VIM
21granular cell tumor10.0VIM
22retinal detachment10.0GFAP
23hemangiopericytoma10.0VIM
24mastocytosis10.0PDGFRA
25fibromatosis10.0VIM
26pilocytic astrocytoma10.0GFAP
27rhabdoid tumor10.0VIM
28paraganglioma10.0GFAP
29multiple system atrophy10.0GFAP
30oligodendroglioma10.0GFAP, PDGFRA
31rhabdoid meningioma10.0VIM, GFAP
32astroblastoma10.0VIM, GFAP
33myoepithelioma10.0VIM, GFAP
34fibrosarcoma10.0PDGFRA, VIM
35pleomorphic adenoma10.0VIM, GFAP
36glioblastoma multiforme10.0PDGFRA, GFAP
37gastrointestinal stromal tumor10.0PDGFRA, VIM
38endometrial stromal sarcoma10.0VIM, PDGFRA
39chondrosarcoma10.0VIM, PDGFRA
40medulloblastoma10.0GFAP, PDGFRA
41malignant peripheral nerve sheath tumor10.0PDGFRA, VIM
42malignant glioma10.0GFAP, PDGFRA
43leiomyoma10.0PDGFRA, VIM
44retinoblastoma10.0GFAP
45neurofibroma10.0VIM, PDGFRA
46anaplastic astrocytoma10.0GFAP, PDGFRA
47peripheral primitive neuroectodermal tumor10.0PDGFRA, VIM
48brain ischemia10.0HSPA4
49angiosarcoma10.0VIM, PDGFRA
50chordoma10.0PDGFRA, GFAP, VIM

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to mixed glioma

Clinical Features for Mixed Glioma

Drugs & Therapeutics for Mixed Glioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mixed Glioma

Drug clinical trials:

Search ClinicalTrials for Mixed Glioma

Search NIH Clinical Center for Mixed Glioma

Search CenterWatch for Mixed Glioma

Genetic Tests for Mixed Glioma

Anatomical Context for Mixed Glioma

Animal Models for Mixed Glioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Mixed Glioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1VIM, PDGFRA, HRC, GFAP
2MP:00053697.8PDGFRA, HRC, GFAP, VIM
3MP:00053867.4PDGFRA, GFAP, HRC, VIM, HSPA4

Publications for Mixed Glioma

Sources:
51PubMed
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Articles related to Mixed Glioma:

(show all 14)
idTitleAuthorsYear
1
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. (21836617)
2012
2
Metachronous gliomas following cranial irradiation for mixed germ cell tumors. (19247675)
2009
3
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. (17252186)
2007
4
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. (12889176)
2003
5
Long-term outcome of low-grade oligodendroglioma and mixed glioma. (10751254)
2000
6
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. (9524101)
1998
7
Exophytic malignant brainstem mixed glioma in an adult: a case report. (9524090)
1998
8
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. (3748360)
1986
9
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. (3713193)
1986
10
Mixed glioma of the cerebellopontine angle. (3878094)
1985
11
Mixed capillary hemangioblastoma and glioma. A redefinition of the "angioglioma". (6684149)
1983
12
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. (6286891)
1982
13
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. (929897)
1977
14
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. (5050901)
1972

Genetic Variations for Mixed Glioma

Expression for genes affiliated with Mixed Glioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for genes affiliated with Mixed Glioma

Sources:
12EMD Millipore, 52QIAGEN
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Pathways related to Mixed Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.2GFAP, VIM
2
Hide members
8.6PDGFRA, HSPA4, VIM

Compounds for genes affiliated with Mixed Glioma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Mixed Glioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1glutamine4510.3GFAP
2pentobarbital45 1110.9HSPA4, GFAP
3phenylbutyrate459.9HSPA4, GFAP
4eosin459.6VIM, GFAP
5s 100459.6GFAP, VIM
6silver459.6GFAP, HSPA4
7reticulin459.6GFAP, VIM
8retinaldehyde459.6VIM, GFAP
9silicone459.6VIM, GFAP
10kainate45 2910.5HSPA4, GFAP
11streptozotocin459.5VIM, GFAP
12hematoxylin459.4GFAP, VIM
13ganciclovir45 1110.4VIM, GFAP
14ganglioside459.4GFAP, VIM
15dbc-amp459.3VIM, GFAP
16chondroitin sulfate45 2410.2VIM, GFAP
17neomycin459.1HSPA4, VIM, GFAP
18cocaine45 1110.1HSPA4, VIM, GFAP
19bromodeoxyuridine459.1GFAP, VIM, HSPA4
20isoproterenol45 1110.1GFAP, HSPA4, VIM
21agar459.1GFAP, HSPA4, VIM
22butyrate459.0GFAP, HSPA4, VIM
23methionine459.0VIM, HSPA4, GFAP
24nocodazole45 1110.0HSPA4, VIM
25nmda45 2910.0VIM, GFAP, HSPA4
26paclitaxel45 50 1111.0GFAP, HSPA4, VIM
27acetylcholine45 50 29 11 2413.0HSPA4, VIM, GFAP
28estradiol45 11 2411.0GFAP, HSPA4, VIM
29genistein45 29 60 2 11 2414.0VIM, GFAP, HSPA4
30iron45 2410.0GFAP, HSPA4, VIM
31lactate459.0GFAP, HSPA4, VIM
32creatinine459.0GFAP, HSPA4, VIM
33adenylate458.9GFAP, VIM, HSPA4
34cycloheximide458.9VIM, GFAP, HSPA4
35progesterone45 60 29 11 2412.9GFAP, HSPA4, VIM
36testosterone45 60 11 2411.7GFAP, HSPA4, VIM
37paraffin458.6GFAP, VIM, HSPA4, PDGFRA
38aspartate458.6PDGFRA, VIM, GFAP, HSPA4
39vegf458.6HSPA4, GFAP, PDGFRA, VIM
40retinoic acid45 249.5HSPA4, VIM, PDGFRA, GFAP
41atp45 299.5VIM, HSPA4, GFAP, PDGFRA
42dexamethasone45 50 29 1111.4HSPA4, GFAP, VIM

GO Terms for genes affiliated with Mixed Glioma

Sources:
16Gene Ontology
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Cellular components related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.2GFAP, VIM

Biological processes related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.2GFAP, VIM
2negative regulation of neuron projection developmentGO:0109779.2GFAP, VIM
3astrocyte developmentGO:0140029.1GFAP, VIM
4intermediate filament organizationGO:0451098.9GFAP, VIM

Molecular functions related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2GFAP, VIM

Products for genes affiliated with Mixed Glioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mixed Glioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet