MCID: MXD026
MIFTS: 39

Mixed Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Mixed Glioma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Mixed Glioma, also known as mixed gliomas, is related to oligodendroglioma and glioblastoma multiforme. An important gene associated with Mixed Glioma is GFAP (glial fibrillary acidic protein), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Nanog in Mammalian ESC Pluripotency. The compounds glutamine and pentobarbital have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and endothelial, and related mouse phenotypes are cardiovascular system and muscle.

Aliases & Classifications for Mixed Glioma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

mixed glioma 8 10 44
mixed gliomas 8 60
mixed neuroglial tumor 8


External Ids:

Disease Ontology8 DOID:5076
NCIt39 C3903
SNOMED-CT56 22217002, 443937008
MeSH34 D005910

Related Diseases for Mixed Glioma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mixed Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma30.2GFAP, PDGFRA
2glioblastoma multiforme30.0PDGFRA, GFAP
3malignant glioma30.0GFAP, PDGFRA
4sarcoma29.9PDGFRA, HSPA4, VIM
5adult brainstem mixed glioma10.4
6oligoastrocytoma10.2
7mixed oligodendroglioma-astrocytoma10.0
8brain glioma10.0
9charcot-marie-tooth disease10.0
10multiple sclerosis10.0
11rhabdomyosarcoma10.0
12tooth disease10.0
13anaplastic oligoastrocytoma10.0
14gliosarcoma10.0GFAP
15giant cell glioblastoma10.0GFAP
16neurilemmoma10.0GFAP
17choroid plexus papilloma10.0GFAP
18subependymal giant cell astrocytoma10.0GFAP
19syringoma10.0GFAP
20clear cell ependymoma10.0VIM
21neurofibromatosis10.0PDGFRA
22perineurioma10.0VIM
23hemangioblastoma10.0GFAP
24brain cancer10.0GFAP
25dermatofibrosarcoma protuberans10.0VIM
26granular cell tumor10.0VIM
27retinal detachment10.0GFAP
28hemangiopericytoma10.0VIM
29pilocytic astrocytoma10.0GFAP
30mastocytosis10.0PDGFRA
31fibromatosis10.0VIM
32rhabdoid tumor10.0VIM
33paraganglioma10.0GFAP
34multiple system atrophy10.0GFAP
35rhabdoid meningioma10.0GFAP, VIM
36astroblastoma10.0GFAP, VIM
37myoepithelioma10.0VIM, GFAP
38fibrosarcoma10.0PDGFRA, VIM
39anaplastic oligodendroglioma10.0GFAP, PDGFRA
40pleomorphic adenoma10.0VIM, GFAP
41gastrointestinal stromal tumor10.0PDGFRA, VIM
42endometrial stromal sarcoma10.0PDGFRA, VIM
43chondrosarcoma10.0PDGFRA, VIM
44medulloblastoma10.0GFAP, PDGFRA
45malignant peripheral nerve sheath tumor10.0VIM, PDGFRA
46leiomyoma10.0PDGFRA, VIM
47retinoblastoma10.0GFAP
48neurofibroma10.0VIM, PDGFRA
49anaplastic astrocytoma10.0GFAP, PDGFRA
50peripheral primitive neuroectodermal tumor10.0VIM, PDGFRA

Graphical network of the top 20 diseases related to Mixed Glioma:



Diseases related to mixed glioma

Clinical Features for Mixed Glioma

About this section

Drugs & Therapeutics for Mixed Glioma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mixed Glioma

Drug clinical trials:

Search ClinicalTrials for Mixed Glioma

Search NIH Clinical Center for Mixed Glioma

Search CenterWatch for Mixed Glioma

Genetic Tests for Mixed Glioma

About this section

Anatomical Context for Mixed Glioma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mixed Glioma:

32
Brain, Cerebellum, Endothelial

Animal Models for Mixed Glioma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mixed Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1GFAP, HRC, PDGFRA, VIM
2MP:00053697.8VIM, PDGFRA, HRC, GFAP
3MP:00053867.4GFAP, HRC, PDGFRA, HSPA4, VIM

Publications for Mixed Glioma

About this section
Sources:
50PubMed
See all sources

Articles related to Mixed Glioma:

(show all 14)
idTitleAuthorsYear
1
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. (21836617)
2012
2
Metachronous gliomas following cranial irradiation for mixed germ cell tumors. (19247675)
2009
3
Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. (17252186)
2007
4
Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. (12889176)
2003
5
Long-term outcome of low-grade oligodendroglioma and mixed glioma. (10751254)
2000
6
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. (9524101)
1998
7
Exophytic malignant brainstem mixed glioma in an adult: a case report. (9524090)
1998
8
Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. (3748360)
1986
9
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma. (3713193)
1986
10
Mixed glioma of the cerebellopontine angle. (3878094)
1985
11
Mixed capillary hemangioblastoma and glioma. A redefinition of the "angioglioma". (6684149)
1983
12
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. (6286891)
1982
13
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. (929897)
1977
14
Mixed glioma, multiple sclerosis, and Charcot-Marie-Tooth disease. (5050901)
1972

Genetic Variations for Mixed Glioma

About this section

Expression for genes affiliated with Mixed Glioma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mixed Glioma

Search GEO for disease gene expression data for Mixed Glioma.

Pathways for genes affiliated with Mixed Glioma

About this section
Sources:
12EMD Millipore, 51QIAGEN
See all sources

Pathways related to Mixed Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.2GFAP, VIM
2
Hide members
8.6PDGFRA, HSPA4, VIM

Compounds for genes affiliated with Mixed Glioma

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mixed Glioma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1glutamine4410.3GFAP
2pentobarbital44 1110.9GFAP, HSPA4
3phenylbutyrate449.9GFAP, HSPA4
4eosin449.6GFAP, VIM
5s 100449.6GFAP, VIM
6silver449.6HSPA4, GFAP
7reticulin449.6VIM, GFAP
8retinaldehyde449.6GFAP, VIM
9silicone449.6GFAP, VIM
10kainate44 2810.5GFAP, HSPA4
11streptozotocin449.5GFAP, VIM
12hematoxylin449.4GFAP, VIM
13ganciclovir44 1110.4GFAP, VIM
14ganglioside449.4GFAP, VIM
15dbc-amp449.3GFAP, VIM
16chondroitin sulfate44 2410.2GFAP, VIM
17neomycin449.1GFAP, HSPA4, VIM
18cocaine44 1110.1VIM, HSPA4, GFAP
19bromodeoxyuridine449.1GFAP, HSPA4, VIM
20isoproterenol44 1110.1VIM, HSPA4, GFAP
21agar449.1GFAP, HSPA4, VIM
22butyrate449.0VIM, HSPA4, GFAP
23methionine449.0GFAP, HSPA4, VIM
24nocodazole44 1110.0VIM, HSPA4
25nmda44 2810.0VIM, HSPA4, GFAP
26paclitaxel44 49 1111.0GFAP, HSPA4, VIM
27acetylcholine44 49 28 11 2413.0GFAP, HSPA4, VIM
28estradiol44 11 2411.0VIM, HSPA4, GFAP
29genistein44 28 59 2 11 2414.0GFAP, HSPA4, VIM
30iron44 2410.0VIM, HSPA4, GFAP
31lactate449.0GFAP, HSPA4, VIM
32creatinine449.0VIM, HSPA4, GFAP
33adenylate448.9GFAP, HSPA4, VIM
34cycloheximide448.9VIM, HSPA4, GFAP
35progesterone44 59 28 11 2412.9VIM, HSPA4, GFAP
36testosterone44 59 11 2411.7GFAP, HSPA4, VIM
37paraffin448.6GFAP, PDGFRA, HSPA4, VIM
38aspartate448.6VIM, HSPA4, PDGFRA, GFAP
39vegf448.6GFAP, PDGFRA, HSPA4, VIM
40retinoic acid44 249.5VIM, HSPA4, PDGFRA, GFAP
41atp44 289.5VIM, HSPA4, PDGFRA, GFAP
42dexamethasone44 49 28 1111.4GFAP, HSPA4, VIM

GO Terms for genes affiliated with Mixed Glioma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.2GFAP, VIM

Biological processes related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.2GFAP, VIM
2negative regulation of neuron projection developmentGO:0109779.2GFAP, VIM
3astrocyte developmentGO:0140029.1GFAP, VIM
4intermediate filament organizationGO:0451098.9GFAP, VIM

Molecular functions related to Mixed Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.2GFAP, VIM

Products for genes affiliated with Mixed Glioma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mixed Glioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet