MCID: MXD003
MIFTS: 30

Mixed Lacrimal Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Mixed Lacrimal Gland Cancer

MalaCards integrated aliases for Mixed Lacrimal Gland Cancer:

Name: Mixed Lacrimal Gland Cancer 12 14
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland 12
Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland 12
Malignant Mixed Neoplasm of Lacrimal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:296
NCIt 46 C6804
SNOMED-CT 64 254989000
UMLS 69 C0346342

Summaries for Mixed Lacrimal Gland Cancer

MalaCards based summary : Mixed Lacrimal Gland Cancer, also known as carcinoma ex pleomorphic adenoma of the lacrimal gland, is related to pleomorphic adenoma carcinoma and pleomorphic adenoma. An important gene associated with Mixed Lacrimal Gland Cancer is TYK2 (Tyrosine Kinase 2), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp and adipose tissue

Related Diseases for Mixed Lacrimal Gland Cancer

Graphical network of the top 20 diseases related to Mixed Lacrimal Gland Cancer:



Diseases related to Mixed Lacrimal Gland Cancer

Symptoms & Phenotypes for Mixed Lacrimal Gland Cancer

GenomeRNAi Phenotypes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp GR00234-A-1 8.62 JAK1 TYK2

MGI Mouse Phenotypes related to Mixed Lacrimal Gland Cancer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 IL6 STAT3 TYK2
2 skeleton MP:0005390 8.92 IL6 JAK1 STAT3 TYK2

Drugs & Therapeutics for Mixed Lacrimal Gland Cancer

Search Clinical Trials , NIH Clinical Center for Mixed Lacrimal Gland Cancer

Genetic Tests for Mixed Lacrimal Gland Cancer

Anatomical Context for Mixed Lacrimal Gland Cancer

Publications for Mixed Lacrimal Gland Cancer

Articles related to Mixed Lacrimal Gland Cancer:

# Title Authors Year
1
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
2
Comprehensive management of a rare carcinoma ex pleomorphic adenoma of the lacrimal gland with a modified lateral orbitotomy access osteotomy. A case report. ( 21445559 )
2012
3
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 18369704 )
2008
4
Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. ( 17881995 )
2007
5
Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. ( 17416946 )
2006

Variations for Mixed Lacrimal Gland Cancer

Expression for Mixed Lacrimal Gland Cancer

Search GEO for disease gene expression data for Mixed Lacrimal Gland Cancer.

Pathways for Mixed Lacrimal Gland Cancer

Pathways related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 IL6 JAK1 STAT3 TYK2
2
Show member pathways
13.09 IL6 JAK1 STAT3 TYK2
3
Show member pathways
12.81 IL6 JAK1 STAT3 TYK2
4
Show member pathways
12.77 IL6 JAK1 STAT3
5
Show member pathways
12.71 IL6 JAK1 TYK2
6
Show member pathways
12.7 IL6 JAK1 TYK2
7 12.6 IL6 JAK1 STAT3
8
Show member pathways
12.6 IL6 JAK1 STAT3 TYK2
9
Show member pathways
12.58 IL6 JAK1 STAT3 TYK2
10
Show member pathways
12.43 IL6 JAK1 STAT3 TYK2
11
Show member pathways
12.42 IL6 JAK1 STAT3 TYK2
12
Show member pathways
12.39 IL6 JAK1 STAT3 TYK2
13 12.37 JAK1 STAT3 TYK2
14
Show member pathways
12.23 JAK1 STAT3 TYK2
15
Show member pathways
12.17 JAK1 STAT3 TYK2
16
Show member pathways
12.16 IL6 JAK1 STAT3
17
Show member pathways
12.16 IL6 JAK1 STAT3 TYK2
18 12.13 JAK1 STAT3 TYK2
19
Show member pathways
12.11 IL6 JAK1 STAT3 TYK2
20
Show member pathways
12.09 JAK1 STAT3 TYK2
21
Show member pathways
12.09 JAK1 STAT3 TYK2
22
Show member pathways
12.06 JAK1 STAT3 TYK2
23 12.03 IL6 JAK1 STAT3
24
Show member pathways
12.01 IL6 JAK1 TYK2
25
Show member pathways
11.92 JAK1 STAT3
26 11.92 JAK1 STAT3 TYK2
27
Show member pathways
11.91 JAK1 STAT3
28
Show member pathways
11.9 IL6 STAT3
29 11.87 JAK1 STAT3
30
Show member pathways
11.87 IL6 STAT3
31
Show member pathways
11.85 JAK1 STAT3
32 11.85 IL6 STAT3
33 11.84 IL6 STAT3
34 11.83 JAK1 TYK2
35
Show member pathways
11.77 STAT3 TYK2
36
Show member pathways
11.76 IL6 JAK1 STAT3
37 11.76 IL6 JAK1 STAT3 TYK2
38
Show member pathways
11.75 IL6 STAT3
39 11.71 IL6 STAT3
40 11.71 IL6 STAT3
41
Show member pathways
11.7 JAK1 STAT3
42
Show member pathways
11.69 IL6 JAK1 STAT3 TYK2
43 11.64 IL6 JAK1 STAT3 TYK2
44
Show member pathways
11.58 IL6 JAK1 STAT3 TYK2
45 11.54 JAK1 STAT3
46 11.51 JAK1 STAT3 TYK2
47
Show member pathways
11.49 IL6 JAK1 STAT3 TYK2
48 11.46 JAK1 STAT3
49 11.46 IL6 JAK1 STAT3
50
Show member pathways
11.41 JAK1 STAT3

GO Terms for Mixed Lacrimal Gland Cancer

Cellular components related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.62 JAK1 TYK2

Biological processes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.67 JAK1 STAT3 TYK2
2 cytokine-mediated signaling pathway GO:0019221 9.52 IL6 STAT3
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.51 JAK1 TYK2
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 IL6 STAT3
5 type I interferon signaling pathway GO:0060337 9.46 JAK1 TYK2
6 peptidyl-tyrosine autophosphorylation GO:0038083 9.43 JAK1 TYK2
7 interleukin-7-mediated signaling pathway GO:0038111 9.4 JAK1 STAT3
8 acute-phase response GO:0006953 9.37 IL6 STAT3
9 regulation of type I interferon-mediated signaling pathway GO:0060338 9.32 JAK1 TYK2
10 interleukin-15-mediated signaling pathway GO:0035723 9.26 JAK1 STAT3
11 interleukin-6-mediated signaling pathway GO:0070102 9.16 IL6 STAT3
12 T-helper 17 cell lineage commitment GO:0072540 8.96 IL6 STAT3
13 interleukin-12-mediated signaling pathway GO:0035722 8.8 JAK1 STAT3 TYK2

Molecular functions related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.26 JAK1 STAT3
2 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.16 JAK1 TYK2
3 CCR5 chemokine receptor binding GO:0031730 8.96 JAK1 STAT3
4 growth hormone receptor binding GO:0005131 8.62 JAK1 TYK2

Sources for Mixed Lacrimal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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