MCID: MXD003
MIFTS: 26

Mixed Lacrimal Gland Cancer

Categories: Cancer diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Mixed Lacrimal Gland Cancer

MalaCards integrated aliases for Mixed Lacrimal Gland Cancer:

Name: Mixed Lacrimal Gland Cancer 12 14
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland 12
Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland 12
Malignant Mixed Neoplasm of Lacrimal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:296
NCIt 47 C6804
SNOMED-CT 64 254989000
UMLS 69 C0346342

Summaries for Mixed Lacrimal Gland Cancer

MalaCards based summary : Mixed Lacrimal Gland Cancer, also known as carcinoma ex pleomorphic adenoma of the lacrimal gland, is related to pleomorphic adenoma and adenoma. An important gene associated with Mixed Lacrimal Gland Cancer is TYK2 (Tyrosine Kinase 2), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp and adipose tissue

Related Diseases for Mixed Lacrimal Gland Cancer

Graphical network of the top 20 diseases related to Mixed Lacrimal Gland Cancer:



Diseases related to Mixed Lacrimal Gland Cancer

Symptoms & Phenotypes for Mixed Lacrimal Gland Cancer

GenomeRNAi Phenotypes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp GR00234-A-1 8.62 JAK1 TYK2

MGI Mouse Phenotypes related to Mixed Lacrimal Gland Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 IL6 STAT3 TYK2
2 skeleton MP:0005390 8.92 IL6 JAK1 STAT3 TYK2

Drugs & Therapeutics for Mixed Lacrimal Gland Cancer

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Mixed Lacrimal Gland Cancer

Genetic Tests for Mixed Lacrimal Gland Cancer

Anatomical Context for Mixed Lacrimal Gland Cancer

Publications for Mixed Lacrimal Gland Cancer

Variations for Mixed Lacrimal Gland Cancer

Expression for Mixed Lacrimal Gland Cancer

Search GEO for disease gene expression data for Mixed Lacrimal Gland Cancer.

Pathways for Mixed Lacrimal Gland Cancer

Pathways related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 IL6 JAK1 STAT3 TYK2
2
Show member pathways
13.08 IL6 JAK1 STAT3 TYK2
3
Show member pathways
12.81 IL6 JAK1 STAT3 TYK2
4
Show member pathways
12.72 IL6 JAK1 TYK2
5
Show member pathways
12.61 IL6 JAK1 STAT3
6
Show member pathways
12.6 IL6 JAK1 STAT3 TYK2
7
Show member pathways
12.59 IL6 JAK1 STAT3 TYK2
8 12.45 IL6 JAK1 STAT3
9
Show member pathways
12.42 IL6 JAK1 STAT3 TYK2
10 12.41 IL6 JAK1 TYK2
11
Show member pathways
12.41 IL6 JAK1 STAT3 TYK2
12 12.34 JAK1 STAT3 TYK2
13
Show member pathways
12.26 IL6 JAK1 STAT3
14
Show member pathways
12.22 JAK1 STAT3 TYK2
15
Show member pathways
12.17 JAK1 STAT3 TYK2
16
Show member pathways
12.16 IL6 JAK1 STAT3
17 12.13 JAK1 STAT3 TYK2
18
Show member pathways
12.11 IL6 JAK1 STAT3 TYK2
19
Show member pathways
12.09 JAK1 STAT3 TYK2
20
Show member pathways
12.06 JAK1 STAT3 TYK2
21 12.03 IL6 JAK1 STAT3
22
Show member pathways
12.02 IL6 JAK1 STAT3 TYK2
23
Show member pathways
12 IL6 JAK1 TYK2
24 11.92 JAK1 STAT3 TYK2
25
Show member pathways
11.91 JAK1 STAT3
26
Show member pathways
11.89 IL6 STAT3
27 11.87 JAK1 STAT3
28
Show member pathways
11.86 IL6 STAT3
29
Show member pathways
11.85 JAK1 STAT3
30 11.85 IL6 STAT3
31 11.84 IL6 STAT3
32 11.82 JAK1 TYK2
33
Show member pathways
11.76 STAT3 TYK2
34
Show member pathways
11.76 IL6 JAK1 STAT3
35 11.76 IL6 JAK1 STAT3 TYK2
36
Show member pathways
11.75 IL6 STAT3
37 11.7 IL6 STAT3
38 11.7 IL6 STAT3
39
Show member pathways
11.7 IL6 JAK1 STAT3 TYK2
40
Show member pathways
11.69 JAK1 STAT3
41 11.68 IL6 JAK1 STAT3 TYK2
42
Show member pathways
11.63 IL6 JAK1 STAT3 TYK2
43 11.53 JAK1 STAT3
44 11.51 JAK1 STAT3 TYK2
45
Show member pathways
11.49 IL6 JAK1 STAT3 TYK2
46 11.46 JAK1 STAT3
47 11.45 IL6 JAK1 STAT3
48
Show member pathways
11.4 JAK1 STAT3
49 11.39 STAT3 TYK2
50 11.38 JAK1 STAT3 TYK2

GO Terms for Mixed Lacrimal Gland Cancer

Cellular components related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.62 JAK1 TYK2

Biological processes related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.7 JAK1 STAT3 TYK2
2 cytokine-mediated signaling pathway GO:0019221 9.57 IL6 STAT3
3 response to organic cyclic compound GO:0014070 9.56 IL6 STAT3
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.55 JAK1 TYK2
5 glucose homeostasis GO:0042593 9.54 IL6 STAT3
6 type I interferon signaling pathway GO:0060337 9.49 JAK1 TYK2
7 response to cytokine GO:0034097 9.48 IL6 STAT3
8 negative regulation of neuron death GO:1901215 9.46 IL6 STAT3
9 peptidyl-tyrosine autophosphorylation GO:0038083 9.43 JAK1 TYK2
10 acute-phase response GO:0006953 9.4 IL6 STAT3
11 response to antibiotic GO:0046677 9.37 IL6 JAK1
12 regulation of cell proliferation GO:0042127 9.33 IL6 JAK1 TYK2
13 cellular response to cytokine stimulus GO:0071345 9.32 IL6 STAT3
14 regulation of type I interferon-mediated signaling pathway GO:0060338 9.26 JAK1 TYK2
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.21 IL6
16 interleukin-6-mediated signaling pathway GO:0070102 8.96 IL6 STAT3
17 T-helper 17 cell lineage commitment GO:0072540 8.62 IL6 STAT3

Molecular functions related to Mixed Lacrimal Gland Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.26 JAK1 STAT3
2 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.16 JAK1 TYK2
3 CCR5 chemokine receptor binding GO:0031730 8.96 JAK1 STAT3
4 growth hormone receptor binding GO:0005131 8.62 JAK1 TYK2

Sources for Mixed Lacrimal Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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