MCID: MXD006
MIFTS: 31

Mixed Liposarcoma malady

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Mixed Liposarcoma

Aliases & Descriptions for Mixed Liposarcoma:

Name: Mixed Liposarcoma 12 14 69
Mixed-Type Liposarcoma 12 14
Myxoid/round Cell Liposarcoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5703 DOID:5709
NCIt 47 C4253 C27781
SNOMED-CT 64 11073003

Summaries for Mixed Liposarcoma

MalaCards based summary : Mixed Liposarcoma, also known as mixed-type liposarcoma, is related to rommen mueller sybert syndrome and primary eye hypotony. An important gene associated with Mixed Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Viral carcinogenesis and PI3K-Akt signaling pathway. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Related phenotype is hematopoietic system.

Related Diseases for Mixed Liposarcoma

Diseases related to Mixed Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 rommen mueller sybert syndrome 10.3 CDK4 MDM2
2 primary eye hypotony 10.3 CDK4 MDM2
3 osteomyelitis 10.3 CDK4 MDM2
4 amelogenesis imperfecta-gingival hyperplasia syndrome 10.3 CDK4 MDM2
5 aortic aneurysm 10.3 CDK4 MDM2
6 liposarcoma of bone 10.3 CDK4 MDM2
7 apocrine sweat gland neoplasm 10.3 CDK4 MDM2
8 localized hypertrophic neuropathy 10.3 CDK4 MDM2
9 extraosseous osteosarcoma 10.2 CDK4 MDM2
10 foix-alajouanine syndrome 10.2 CREB3L2 FUS
11 acromegaly 10.2 HBA1 PDGFB
12 pleomorphic adenoma 10.2 CD34 HBA1
13 basophil adenoma 10.2 CD34 HBA1
14 sarcocystosis 10.2 CD34 HBA1
15 house allergic alveolitis 10.2 CDK4 MDM2
16 dermoid cyst 10.2 CD34 HBA1
17 rhabdomyosarcoma 2, alveolar 10.2 CDK4 MB MDM2
18 thyroid angiosarcoma 10.2 CD34 HBA1
19 cervix endometrial stromal tumor 10.2 CD34 HBA1
20 adenosarcoma 10.2 CDK4 MB MDM2
21 vulvar dystrophy 10.2 CD34 HBA1
22 breast juvenile papillomatosis 10.2 CD34 HBA1
23 brain stem infarction 10.2 MB PDGFB
24 superior vena cava angiosarcoma 10.1 CD34 HBA1
25 embryonal extrahepatic bile duct rhabdomyosarcoma 10.1 CDK4 MB MDM2
26 phencyclidine abuse 10.1 CD34 HBA1
27 skin angiosarcoma 10.1 CD34 HBA1
28 glucosephosphate isomerase deficiency 10.1 CDK4 MDM2 PDGFB
29 brain stem angioblastoma 10.1 CD34 CDK4 MDM2
30 multifocal osteogenic sarcoma 10.1 CDK4 CREB3L2 MDM2
31 breast mucoepidermoid carcinoma 10.1 CD34 HBA1
32 alcohol-induced mental disorder 10.1 CD34 HBA1
33 thoracic outlet syndrome 10.1 CD34 CDK4 MDM2
34 cycloplegia 10.1 CD34 HBA1
35 glaucoma iridogoniodysgenesia 10.1 CD68 MB
36 vulvar vestibulitis syndrome 10.1 CD68 MB
37 intraneural perineurioma 10.1 CD34 CREB3L2
38 pulmonary immaturity 10.1 CDK4 FUS MB MDM2
39 ossifying fibromyxoid tumor 10.1 CD34 CDK4 HBA1
40 microsporidiosis 10.1 CD34 HBA1 MB
41 malignant pleural solitary fibrous tumor 10.1 CD34 CDK4 MB
42 anthrax disease 10.0 CD68 HBA1
43 small intestinal sarcoma 10.0 CREB3L2 MDM2
44 uterine benign neoplasm 10.0 CD34 HBA1 MB
45 conventional leiomyosarcoma 10.0 CD34 HBA1 MB
46 hyperpituitarism 10.0 CD34 HBA1 MB
47 teeth hard tissue disease 10.0 CD68 HBA1
48 ulnar neuropathy 10.0 CD68 PDGFB
49 mucoepidermoid esophageal carcinoma 10.0 CD34 CREB3L2
50 adult spinal cord ependymoma 10.0 CD34 CD68

Graphical network of the top 20 diseases related to Mixed Liposarcoma:



Diseases related to Mixed Liposarcoma

Symptoms & Phenotypes for Mixed Liposarcoma

MGI Mouse Phenotypes related to Mixed Liposarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 CD34 CD68 CDK4 DDIT3 MB MDM2

Drugs & Therapeutics for Mixed Liposarcoma

Drugs for Mixed Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved Phase 3 51-75-2 4033
4
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
5
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
6
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
8
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
9
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
10
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
13 Alkylating Agents Phase 3,Phase 2,Phase 1
14 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
15 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
16 Isophosphamide mustard Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
18 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
19 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
20 Etoposide phosphate Phase 3,Phase 2
21 Anti-Infective Agents Phase 3,Phase 2
22 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
23 Antimitotic Agents Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
26
Histamine Phosphate Phase 3 51-74-1 65513
27
Serotonin Phase 3 50-67-9 5202
28 Serotonin Agents Phase 3
29 Serotonin Antagonists Phase 3
30 Gastrointestinal Agents Phase 3
31 Neurotransmitter Agents Phase 3
32 Histamine Antagonists Phase 3
33 Histamine H1 Antagonists Phase 3
34 Dermatologic Agents Phase 3
35 Anti-Allergic Agents Phase 3
36 Antipruritics Phase 3
37
Lenograstim Approved Phase 2 135968-09-1
38
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
39
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
40
Gemcitabine Approved Phase 2 95058-81-4 60750
41
saracatinib Phase 2
42 Angiogenesis Inhibitors Phase 2
43 Angiogenesis Modulating Agents Phase 2
44 Antimetabolites Phase 2,Phase 1
45 Antimetabolites, Antineoplastic Phase 2,Phase 1
46 Antiviral Agents Phase 2
47
Fluorouracil Approved Phase 1 51-21-8 3385
48
Belinostat Approved, Investigational Phase 1 866323-14-0
49 Histone Deacetylase Inhibitors Phase 1
50 Androgens Phase 1

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
2 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
3 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
4 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2
5 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
6 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
7 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
8 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2
9 A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Recruiting NCT03096912 Phase 2
10 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
11 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
12 Vaccine Therapy and Sargramostim in Treating Patients With Sarcoma or Brain Tumor Completed NCT00069940 Phase 1
13 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1
14 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1
15 Adoptive Therapy Using Antigen-Specific CD4 T-Cells Not yet recruiting NCT02210104 Phase 1
16 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046

Search NIH Clinical Center for Mixed Liposarcoma

Genetic Tests for Mixed Liposarcoma

Anatomical Context for Mixed Liposarcoma

Publications for Mixed Liposarcoma

Articles related to Mixed Liposarcoma:

id Title Authors Year
1
Spermatic cord mixed liposarcoma. Case report and review of the literature. ( 18273513 )
2008
2
Radiologically and histologically mixed liposarcoma: a report of two biphasic cases. ( 14594943 )
2003

Variations for Mixed Liposarcoma

Expression for Mixed Liposarcoma

Search GEO for disease gene expression data for Mixed Liposarcoma.

Pathways for Mixed Liposarcoma

Pathways related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.8 CDK4 CREB3L2 MDM2
2 11.79 CDK4 CREB3L2 MDM2 PDGFB
3 11.69 DDIT3 FUS MDM2
4 11.38 CDK4 MDM2 PDGFB
5 10.87 CDK4 MDM2
6 9.53 HBA1 MB

GO Terms for Mixed Liposarcoma

Biological processes related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.61 MB MDM2 PDGFB
2 negative regulation of gene expression GO:0010629 9.54 CD34 MDM2 PDGFB
3 positive regulation of cell cycle GO:0045787 9.46 CDK4 MDM2
4 cellular response to organic substance GO:0071310 9.4 CD68 MDM2
5 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.26 MDM2 PDGFB
7 oxygen transport GO:0015671 9.16 HBA1 MB
8 positive regulation of vascular associated smooth muscle cell migration GO:1904754 8.96 MDM2 PDGFB
9 paracrine signaling GO:0038001 8.62 CD34 PDGFB

Molecular functions related to Mixed Liposarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxygen transporter activity GO:0005344 8.62 HBA1 MB

Sources for Mixed Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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