MCID: MXD019
MIFTS: 22

Mixed Malaria

Categories: Infectious diseases

Aliases & Classifications for Mixed Malaria

MalaCards integrated aliases for Mixed Malaria:

Name: Mixed Malaria 12 14 69
Malaria Fever by More Than One Parasite 12
Malaria by More Than One Parasite 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14325
ICD9CM 35 084.5
SNOMED-CT 64 21070001
UMLS 69 C0153121

Summaries for Mixed Malaria

Disease Ontology : 12 A malaria that involves infection with more than one species of Plasmodium at the same time.

MalaCards based summary : Mixed Malaria, also known as malaria fever by more than one parasite, is related to malaria and cholecystitis. An important gene associated with Mixed Malaria is RCAN1 (Regulator Of Calcineurin 1), and among its related pathways/superpathways is Role of Calcineurin-dependent NFAT signaling in lymphocytes. The drugs Artemether and chloroquine have been mentioned in the context of this disorder.

Related Diseases for Mixed Malaria

Diseases related to Mixed Malaria via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 malaria 29.1 ACKR1 F3 MT-CYB
2 cholecystitis 9.6
3 acalculous cholecystitis 9.6
4 acute disseminated encephalomyelitis 9.6
5 acute interstitial pneumonia 9.4 ACKR1 MT-CYB
6 endomyocardial fibrosis 9.3 MT-CYB NPCDR1
7 suppurative thyroiditis 6.7 ACKR1 CD80 F3 LRSAM1 MT-CYB NPCDR1

Graphical network of the top 20 diseases related to Mixed Malaria:



Diseases related to Mixed Malaria

Symptoms & Phenotypes for Mixed Malaria

Drugs & Therapeutics for Mixed Malaria

Drugs for Mixed Malaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Artemether Approved Phase 4 71963-77-4 119380 68911
2
chloroquine Approved, Vet_approved Phase 4 54-05-7 2719
3
Lumefantrine Approved Phase 4 82186-77-4 6437380
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Primaquine Approved Phase 4 90-34-6 4908
6
Artesunate Approved Phase 4,Phase 2,Phase 3,Phase 1 88495-63-0 6917864 5464098
7
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
8
Sulfadoxine Approved Phase 4 2447-57-6 17134
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
11 Analgesics Phase 4,Phase 3
12 Analgesics, Non-Narcotic Phase 4,Phase 3
13 Anthelmintics Phase 4
14 Antifungal Agents Phase 4
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Anti-Inflammatory Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Antimalarials Phase 4,Phase 2,Phase 3,Phase 1
19 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Antirheumatic Agents Phase 4
22 Artemether-lumefantrine combination Phase 4
23 Artemisinine Phase 4,Phase 2,Phase 3,Phase 1
24 Artemisinins Phase 4,Phase 2,Phase 3,Phase 1
25 Chloroquine diphosphate Phase 4 50-63-5
26 Peripheral Nervous System Agents Phase 4,Phase 3
27
Dihydroartemisinin Phase 4,Phase 1 71939-50-9 6918483
28
Piperaquine Phase 4,Phase 1 4085-31-8 5079497
29 Folic Acid Antagonists Phase 4
30 Renal Agents Phase 4
31 Vitamin B Complex Phase 4
32 Folate Nutraceutical Phase 4
33 Vitamin B9 Nutraceutical Phase 4
34
Mefloquine Approved Phase 2, Phase 3,Phase 1 53230-10-7 4046
35
Quinine Approved Phase 3 130-95-0 8549 3034034
36 Neuromuscular Agents Phase 3
37 Pharmaceutical Solutions Phase 3
38 Red Cinchona Nutraceutical Phase 3
39 Vaccines Phase 1, Phase 2
40
Aluminum hydroxide Approved Phase 1 21645-51-2
41 Adjuvants, Immunologic Phase 1
42 Antacids Phase 1
43 Anti-Ulcer Agents Phase 1
44 Gastrointestinal Agents Phase 1
45 Aluminum phosphate Phase 1
46
Iron Approved 7439-89-6 23925
47
Amodiaquine Approved 86-42-0 2165
48
Lactitol Investigational 585-86-4 3871
49 Micronutrients
50 Trace Elements

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh Completed NCT02389374 Phase 4 chloroquine;Artemether-lumefantrine combination;Primaquine;Primaquine
2 Prevention of Malaria With Dihydroartemisinine + Piperaquine for Forest Rangers Completed NCT02788864 Phase 4 Arterakine (DHA/piperaquine);Placebo
3 A Study to Assess Current Standard Malaria Treatment Guidelines in the Republic of the Sudan Completed NCT02592408 Phase 4 ASP;SDPQ;14DPQ;14DPQ on Day 42
4 Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes Completed NCT02090036 Phase 4 Primaquine (For artemether-lumefantrine+primaquine arm);Placebo (For artemether-lumefantrine arm)
5 Pharmacokinetic of Mefloquine-Artesunate in Plasmodium Falciparum Malaria Infection in Pregnancy Completed NCT00701961 Phase 2, Phase 3 Mefloquine-artesunate
6 A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon Completed NCT02563704 Phase 3 Artesunate;Quinine
7 A Safety and Efficacy Study of ChAd63/MVA METRAP + RTS,S Completed NCT01883609 Phase 1, Phase 2
8 Adjuvanting Viral Vectored Malaria Vaccines With Matrix M Completed NCT01669512 Phase 1
9 Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults Completed NCT02174978 Phase 1
10 Phase I Study of AMA1-C1/Alhydrogel® (Registered Trademark) + CPG 7909 Malaria Vaccine Completed NCT00427167 Phase 1 AMA1-C1/Alhydrogel + CPG 7909
11 PpPfs25/ISA51 and ScPvs25/ISA51 Vaccines for Malaria Completed NCT00295581 Phase 1 PpPfs25/ISA51 & ScPvs25/ISA51
12 EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults Completed NCT01026246 Phase 1 Placebo
13 Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia Recruiting NCT02612545 Phase 1 Dihydroartemisinin-piperaquine (DHA-PPQ);Mefloquine (MQ)
14 A Study to Assess the Safety and Immunogenicity of the Malaria Vaccine, R21, Administered With and Without Matrix-M1 Active, not recruiting NCT02572388 Phase 1
15 Nutrigenomics, PUFA, Iron and Cognition Amongst Under-two-year-old Indonesian Children Unknown status NCT01504633
16 Optimizing Sysmex Technology as an Innovative Tool to Differentiate Between Malaria (PALUdism) and BACterial Infections in a Malaria Endemic Region Completed NCT02669823
17 Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria Completed NCT02528279 Coartem
18 Frequency and Distribution of Mixed Falciparum-vivax Infections in French Guiana Completed NCT02903758
19 Evaluating the Efficacy of Artesunate-mefloquine and the Relative Roles of Resistance Genetic Markers Completed NCT02427360
20 Treatment of Non-falciparum Malaria Completed NCT00725777 artemether-lumefantrine
21 Partnership and Dignity: a Mixed-methods Survey on Supporting and Retaining Uganda's Village Health Teams Completed NCT02374580
22 Adherence to Antimalarial Drugs in Sierra Leone Completed NCT01967472 amodiaquine-artesunate (AQAS) co-formulated;Artemether-lumefantrine combination (AL)
23 Community Based Management of Severe Malnutrition in Tribal Area of Melghat- Cluster Randomized Control Field Trial Completed NCT02671786
24 Integrated Infectious Disease Capacity-Building Evaluation Completed NCT01190540
25 Improving Iron Status of Children: Potential of Amaranth Completed NCT01224535
26 Diagnosing Pneumonia Under Low-resource Conditions Completed NCT01997047
27 Prevalence Survey of Antimalarial Drug Resistance Markers Not yet recruiting NCT03217851

Search NIH Clinical Center for Mixed Malaria

Genetic Tests for Mixed Malaria

Anatomical Context for Mixed Malaria

Publications for Mixed Malaria

Articles related to Mixed Malaria:

(show all 15)
id Title Authors Year
1
Early treatment failure in concurrent dengue and mixed malaria species infection with suspected resistance to artemisinin combination therapy from a tertiary care center in Delhi: a case report. ( 28860870 )
2017
2
Molecular investigation of mixed malaria infections in southwest Saudi Arabia. ( 25719595 )
2015
3
Molecular evidence of Plasmodium vivax mono and mixed malaria parasite infections in Duffy-negative native Cameroonians. ( 25084090 )
2014
4
Infectious disease case: mixed malaria infection with Plasmodium falciparum and Plasmodium vivax in a deployed service member in Afghanistan. ( 22128640 )
2011
5
A review of mixed malaria species infections in anopheline mosquitoes. ( 21880138 )
2011
6
Acute disseminated encephalomyelitis after mixed malaria infection (Plasmodium falciparum and Plasmodium vivax) with MRI closely simulating multiple sclerosis. ( 21881471 )
2011
7
A mixed malaria infection: is Plasmodium vivax good for you? ( 19740502 )
2010
8
Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination. ( 20409349 )
2010
9
Acute acalculous cholecystitis complicating an imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium vivax. ( 19932042 )
2010
10
Symmetric peripheral gangrene with mixed malaria. ( 17595506 )
2007
11
Mixed malaria infection. ( 10071374 )
1999
12
Transmission of mixed malaria species and strains by mosquitoes, as detected by PCR, in a study area in Guinea-Bissau. ( 9419850 )
1997
13
Comparative efficacy of combination fansidar-sulphate quinine and fansidar-chloroquine in mixed malaria infections of P. falciparum-P. vivax in children. ( 1956694 )
1991
14
Malarial infections in Aotus trivirgatus with special reference to renal pathology. II. P. falciparum and mixed malaria infections. ( 813757 )
1975
15
Leukemoid reaction due to mixed malaria infection; report of a case. ( 18110690 )
1949

Variations for Mixed Malaria

Expression for Mixed Malaria

Search GEO for disease gene expression data for Mixed Malaria.

Pathways for Mixed Malaria

Pathways related to Mixed Malaria according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.33 RCAN1 XPO1

GO Terms for Mixed Malaria

Sources for Mixed Malaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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