MCID: MXD031
MIFTS: 32

Mixed-Type Liposarcoma malady

Cancer diseases category
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Summaries for Mixed-Type Liposarcoma

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33MalaCards
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MalaCards: Mixed-Type Liposarcoma, also known as mixed liposarcoma, is related to liposarcoma and fibrous histiocytoma. An important gene associated with Mixed-Type Liposarcoma is FUS (fused in sarcoma), and among its related pathways are Transcriptional misregulation in cancer and Glioma. The compounds roscovitine and fludarabine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and reproductive system.

Aliases & Classifications for Mixed-Type Liposarcoma

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mixed-type liposarcoma 8
mixed liposarcoma 8 62


External Ids:

Disease Ontology8 DOID:5709, DOID:5703
SNOMED-CT58 11073003

Related Diseases for Mixed-Type Liposarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mixed-Type Liposarcoma:



Diseases related to mixed-type liposarcoma

Symptoms for Mixed-Type Liposarcoma

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Drugs & Therapeutics for Mixed-Type Liposarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Mixed-Type Liposarcoma

Search NIH Clinical Center for Mixed-Type Liposarcoma

Genetic Tests for Mixed-Type Liposarcoma

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Anatomical Context for Mixed-Type Liposarcoma

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Animal Models for Mixed-Type Liposarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Mixed-Type Liposarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5CDK4, MDM2, FUS
2MP:00053898.4CDK4, MDM2, FUS
3MP:00053978.2CDK4, MDM2, FUS

Publications for Mixed-Type Liposarcoma

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52PubMed
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Articles related to Mixed-Type Liposarcoma:

idTitleAuthorsYear
1
Giant mixed-type liposarcoma of the mesentery: case report. (22920010)
2012
2
Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis. (20473880)
2011
3
Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity. (18551309)
2008
4
Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. (19097538)
2008
5
Gene expression in mixed type liposarcoma. (16581650)
2006
6
Mixed-type liposarcoma of the oral cavity: a case with unusual features and a long survival. (10069544)
1999
7
Case of retroperitoneal dedifferentiated mixed-type liposarcoma: comparison of proliferative activity in specimens from four operations. (10477874)
1999
8
Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11) (7889498)
1995
9
Case report 637. Mixed type liposarcoma with myxoid and pleomorphic patterns. (2255956)
1990

Variations for Mixed-Type Liposarcoma

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Expression for genes affiliated with Mixed-Type Liposarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed-Type Liposarcoma

Search GEO for disease gene expression data for Mixed-Type Liposarcoma.

Pathways for genes affiliated with Mixed-Type Liposarcoma

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 54R&D Systems, 60Thomson Reuters, 57SinoBiological
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Pathways related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FUS, MDM2
2
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CDK4, MDM2
3
Show member pathways
9.1CDK4, MDM2
4
Show member pathways
9.1MDM2, CDK4
59.1CDK4, MDM2
69.1MDM2, CDK4
79.1CDK4, MDM2
89.1CDK4, MDM2
9
Show member pathways
9.1CDK4, MDM2
10
Show member pathways
9.1CDK4, MDM2
119.1MDM2, CDK4
12
Show member pathways
Cell cycle38
9.1CDK4, MDM2
139.1CDK4, MDM2
149.1MDM2, CDK4
159.1CDK4, MDM2
169.1CDK4, MDM2
17
Show member pathways
DNA damage response38
9.1CDK4, MDM2
189.1MDM2, CDK4
19
Show member pathways
9.1MDM2, CDK4
20
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.1CDK4, MDM2
21
Show member pathways
9.1CDK4, MDM2
229.1CDK4, MDM2

Compounds for genes affiliated with Mixed-Type Liposarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1roscovitine459.5CDK4, MDM2
2fludarabine45 51 1111.5MDM2, CDK4
3benzo(a)pyrene459.5MDM2, CDK4
4flavopiridol45 1110.5CDK4, MDM2
5trastuzumab45 51 1111.5CDK4, MDM2
6gefitinib45 51 1111.5CDK4, MDM2
7carboplatin45 51 1111.5MDM2, CDK4
8adpribose459.5CDK4, MDM2
9geldanamycin45 51 61 1112.5CDK4, MDM2
10lactacystin459.5CDK4, MDM2
11sp 60012545 6110.5MDM2, CDK4
12lead459.5CDK4, MDM2
13thymidylate459.4CDK4, MDM2
14resveratrol45 61 24 1112.4MDM2, CDK4
15camptothecin45 61 1111.4CDK4, MDM2
16curcumin459.4CDK4, MDM2
17valine459.4CDK4, MDM2
185fluorouracil459.4MDM2, CDK4
19agar459.4CDK4, MDM2
20paclitaxel45 51 1111.4CDK4, MDM2
21rapamycin459.3CDK4, MDM2
22pd 98,059459.3MDM2, CDK4
23ly294002459.3CDK4, MDM2
24doxorubicin45 51 1111.2CDK4, MDM2
25glycogen45 2410.2CDK4, MDM2
26estradiol45 24 1111.1MDM2, CDK4
27proline459.1CDK4, MDM2
28paraffin459.0CDK4, MDM2
29zinc45 249.9CDK4, MDM2, FUS
30genistein45 29 61 3 24 1113.8CDK4, MDM2

GO Terms for genes affiliated with Mixed-Type Liposarcoma

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16Gene Ontology
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Cellular components related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.5CDK4, MDM2, FUS
2nucleoplasmGO:0056548.2CDK4, MDM2, FUS

Biological processes related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1CDK4, MDM2
2negative regulation of cell cycle arrestGO:0711578.8CDK4, MDM2

Products for genes affiliated with Mixed-Type Liposarcoma

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Sources for Mixed-Type Liposarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet