MCID: MXD031
MIFTS: 32

Mixed-Type Liposarcoma malady

Cancer diseases category

Summaries for Mixed-Type Liposarcoma

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34MalaCards
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MalaCards: Mixed-Type Liposarcoma, also known as mixed liposarcoma, is related to liposarcoma and fibrous histiocytoma. An important gene associated with Mixed-Type Liposarcoma is FUS (fused in sarcoma), and among its related pathways are Transcriptional misregulation in cancer and Glioma. The compounds roscovitine and fludarabine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and reproductive system.

Aliases & Classifications for Mixed-Type Liposarcoma

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Sources:
9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mixed-type liposarcoma 9
mixed liposarcoma 9 63


External Ids:

Disease Ontology9 DOID:5709, DOID:5703
SNOMED-CT59 11073003

Related Diseases for Mixed-Type Liposarcoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Mixed-Type Liposarcoma:



Diseases related to mixed-type liposarcoma

Symptoms for Mixed-Type Liposarcoma

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Drugs & Therapeutics for Mixed-Type Liposarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Mixed-Type Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Mixed-Type Liposarcoma

Search NIH Clinical Center for Mixed-Type Liposarcoma

Search CenterWatch for Mixed-Type Liposarcoma

Genetic Tests for Mixed-Type Liposarcoma

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Anatomical Context for Mixed-Type Liposarcoma

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Animal Models for Mixed-Type Liposarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mixed-Type Liposarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5CDK4, MDM2, FUS
2MP:00053898.4CDK4, MDM2, FUS
3MP:00053978.2CDK4, MDM2, FUS

Publications for Mixed-Type Liposarcoma

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53PubMed
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Articles related to Mixed-Type Liposarcoma:

idTitleAuthorsYear
1
Giant mixed-type liposarcoma of the mesentery: case report. (22920010)
2012
2
Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis. (20473880)
2011
3
Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity. (18551309)
2008
4
Retroperitoneal mixed-type liposarcoma showing features of four different subtypes. (19097538)
2008
5
Gene expression in mixed type liposarcoma. (16581650)
2006
6
Mixed-type liposarcoma of the oral cavity: a case with unusual features and a long survival. (10069544)
1999
7
Case of retroperitoneal dedifferentiated mixed-type liposarcoma: comparison of proliferative activity in specimens from four operations. (10477874)
1999
8
Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11) (7889498)
1995
9
Case report 637. Mixed type liposarcoma with myxoid and pleomorphic patterns. (2255956)
1990

Variations for Mixed-Type Liposarcoma

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Expression for genes affiliated with Mixed-Type Liposarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mixed-Type Liposarcoma

Search GEO for disease gene expression data for Mixed-Type Liposarcoma.

Pathways for genes affiliated with Mixed-Type Liposarcoma

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 5Cell Signaling Technology, 55R&D Systems, 61Thomson Reuters, 58SinoBiological
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Pathways related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FUS, MDM2
2
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CDK4, MDM2
3
Show member pathways
9.1CDK4, MDM2
4
Show member pathways
9.1MDM2, CDK4
59.1CDK4, MDM2
69.1MDM2, CDK4
79.1CDK4, MDM2
89.1CDK4, MDM2
9
Show member pathways
9.1CDK4, MDM2
10
Show member pathways
9.1CDK4, MDM2
119.1MDM2, CDK4
12
Show member pathways
Cell cycle39
9.1CDK4, MDM2
139.1CDK4, MDM2
149.1MDM2, CDK4
159.1CDK4, MDM2
169.1CDK4, MDM2
17
Show member pathways
DNA damage response39
9.1CDK4, MDM2
189.1MDM2, CDK4
19
Show member pathways
9.1MDM2, CDK4
20
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.1CDK4, MDM2
21
Show member pathways
9.1CDK4, MDM2
229.1CDK4, MDM2

Compounds for genes affiliated with Mixed-Type Liposarcoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1roscovitine469.5CDK4, MDM2
2fludarabine46 52 1211.5MDM2, CDK4
3benzo(a)pyrene469.5MDM2, CDK4
4flavopiridol46 1210.5CDK4, MDM2
5trastuzumab46 52 1211.5CDK4, MDM2
6gefitinib46 52 1211.5CDK4, MDM2
7carboplatin46 52 1211.5MDM2, CDK4
8adpribose469.5CDK4, MDM2
9geldanamycin46 52 62 1212.5CDK4, MDM2
10lactacystin469.5CDK4, MDM2
11sp 60012546 6210.5MDM2, CDK4
12lead469.5CDK4, MDM2
13thymidylate469.4CDK4, MDM2
14resveratrol46 62 25 1212.4MDM2, CDK4
15camptothecin46 62 1211.4CDK4, MDM2
16curcumin469.4CDK4, MDM2
17valine469.4CDK4, MDM2
185fluorouracil469.4MDM2, CDK4
19agar469.4CDK4, MDM2
20paclitaxel46 52 1211.4CDK4, MDM2
21rapamycin469.3CDK4, MDM2
22pd 98,059469.3MDM2, CDK4
23ly294002469.3CDK4, MDM2
24doxorubicin46 52 1211.2CDK4, MDM2
25glycogen46 2510.2CDK4, MDM2
26estradiol46 25 1211.1MDM2, CDK4
27proline469.1CDK4, MDM2
28paraffin469.0CDK4, MDM2
29zinc46 259.9CDK4, MDM2, FUS
30genistein46 30 62 3 25 1213.8CDK4, MDM2

GO Terms for genes affiliated with Mixed-Type Liposarcoma

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Sources:
17Gene Ontology
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Cellular components related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.5CDK4, MDM2, FUS
2nucleoplasmGO:0056548.2CDK4, MDM2, FUS

Biological processes related to Mixed-Type Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1CDK4, MDM2
2negative regulation of cell cycle arrestGO:0711578.8CDK4, MDM2

Products for genes affiliated with Mixed-Type Liposarcoma

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  • Antibodies
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Sources for Mixed-Type Liposarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet