MN1
MCID: MN1001
MIFTS: 32

Mn1 (MN1) malady

Summaries for Mn1

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32MalaCards
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MalaCards: Mn1, also known as meningioma 1 gene, is related to meningioma and leukemia. An important gene associated with Mn1 is SRA1 (steroid receptor RNA activator 1), and among its related pathways are C-MYB transcription factor network and Development IGF-RI signaling. The compounds estrogen and pkh 2 have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Mn1

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42NIH Rare Diseases
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Aliases & Descriptions:

mn1 42
meningioma 1 gene 42


Related Diseases for Mn1

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17GeneCards, 18GeneDecks
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Diseases related to Mn1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma31.0MN1, SRA1
2leukemia30.7BAALC, MN1, VDR, EP300, HOXA9, ETV6
3myeloid leukemia30.7KITLG, ERG, VDR, ETV6, HOXA9, IL3
4acute leukemia30.6CEBPA, NOTCH1, KITLG, HOXA9, ETV6, IL3
5myelodysplastic syndromes30.1HOXA9, MECOM, VDR, EP300, IL3, KITLG
6prostatitis29.9VDR
7multiple myeloma29.9TP53
8myeloproliferative disorder29.8IL3, KITLG, ETV6
9myeloma29.8NOTCH1, KITLG, IL3, BCL2L11
10prostate cancer29.8NOTCH1, TP53, IGFBP5, VDR, EP300, BCL2L11
11acute myeloid leukemia10.4
12cleft palate10.1
13conjunctivitis10.1
14t-cell leukemia10.1
15refractory anemia with excess blasts10.1
16refractory anemia10.1
17acute monocytic leukemia10.0EP300
18dyskeratosis congenita10.0KITLG
19hyperparathyroidism10.0VDR
20pancreatitis10.0KITLG
21leukemoid reaction10.0IL3
22lung cancer10.0TP53
23neuroblastoma10.0TP53
24graves' disease10.0VDR
25liposarcoma10.0TP53
26kidney cancer10.0TP53
27wilms tumor10.0NOTCH1
28fanconi's anemia10.0IL3, KITLG
29deficiency anemia10.0KITLG, IL3
30severe combined immunodeficiency10.0IL3, KITLG
31thrombocytosis10.0KITLG, IL3
32fibrosarcoma10.0ETV6, EP300
33severe congenital neutropenia10.0KITLG, IL3
34arthritis10.0VDR
35psoriasis10.0VDR
36down syndrome10.0ERG, ETV6
37endometrial carcinoma10.0TP53, EP300
38polycythemia vera10.0KITLG, IL3
39precursor b-cell acute lymphoblastic leukemia10.0KITLG, ETV6, IL3
40erythrocytosis10.0KITLG, IL3
41glioblastoma multiforme10.0TP53, BCL2L11, IGFBP5
42peripheral primitive neuroectodermal tumor10.0KITLG, EP300, ERG
43nephroblastoma10.0MECOM, TP53
44cervical cancer10.0NOTCH1, EP300, TP53
45precursor t-cell acute lymphoblastic leukemia10.0ETV6, NOTCH1, IL3
46pancreatic cancer10.0TP53, NOTCH1, VDR, BCL2L11
47adenoma10.0IGFBP5, TP53, VDR, KITLG
48chronic myeloid leukemia10.0ETV6, HOXA9, MECOM, IL3, KITLG
49retinoblastoma10.0IGFBP5, EP300, CEBPA, VDR, TP53
50non-hodgkin lymphoma10.0VDR, IL3, NOTCH1, ETV6, KITLG

Graphical network of the top 20 diseases related to Mn1:



Diseases related to mn1

Clinical Features for Mn1

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Drugs & Therapeutics for Mn1

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mn1

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Anatomical Context for Mn1

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Animal Models for Mn1 or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mn1:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.4MYBBP1A
2MP:00053719.6MECOM, HOXA9, BCL2L11
3MP:00053889.2MECOM, MN1, EP300, NOTCH1, TP53
4MP:00053909.1MN1, HOXA9, KITLG, NOTCH1, LARGE
5MP:00053779.1MECOM, VDR, KITLG, NOTCH1, LARGE, BCL2L11
6MP:00053698.7MECOM, IGFBP5, VDR, EP300, NOTCH1, LARGE
7MP:00036318.5MECOM, VDR, KITLG, LARGE, ERG
8MP:00053828.5MECOM, VDR, MN1, EP300, KITLG, NOTCH1
9MP:00107718.3VDR, ETV6, HOXA9, KITLG, NOTCH1, BCL2L11
10MP:00028738.2TP53, CEBPA, BCL2L11, ERG, NOTCH1, ETV6
11MP:00053818.2VDR, MN1, ETV6, EP300, KITLG, NOTCH1
12MP:00053898.2MECOM, VDR, HOXA9, KITLG, LARGE, BCL2L11
13MP:00020068.1TP53, MECOM, MN1, ETV6, EP300, IL3
14MP:00053798.0IGFBP5, VDR, ETV6, HOXA9, IL3, KITLG
15MP:00053847.5MECOM, VDR, ETV6, EP300, IL3, KITLG
16MP:00053857.5MECOM, VDR, ETV6, EP300, KITLG, NOTCH1
17MP:00053977.2MECOM, VDR, ETV6, EP300, HOXA9, IL3
18MP:00053787.0EP300, ETV6, VDR, IGFBP5, MECOM, HOXA9
19MP:00053876.9HOXA9, EP300, ETV6, VDR, MECOM, IL3
20MP:00053766.8EP300, ETV6, MN1, VDR, IGFBP5, MECOM
21MP:00107686.7EP300, ETV6, MN1, VDR, MYBBP1A, MECOM

Publications for Mn1

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Genetic Variations for Mn1

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Expression for genes affiliated with Mn1

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mn1

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Pathways for genes affiliated with Mn1

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37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Mn1 according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8EP300, KITLG, CEBPA
2
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9.7TP53, BCL2L11, IGFBP5
39.7IGFBP5, IL3, TP53
4
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9.7EP300, NOTCH1, TP53
59.5CEBPA, KITLG, IL3, MECOM
69.4TP53, BCL2L11, KITLG, IL3
79.3VDR, EP300, HOXA9, TP53
8
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9.3EP300, IL3, KITLG, CEBPA, TP53
9
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9.2TP53, BCL2L11, KITLG, IL3, EP300
109.2TP53, CEBPA, KITLG, EP300, MECOM
11
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9.0EP300, IL3, KITLG, NOTCH1, BCL2L11, TP53
128.9MIR181B2, EP300, NOTCH1, BCL2L11, TP53
13
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8.6EP300, IL3, KITLG, NOTCH1, SRA1, PELP1
148.4TP53, CEBPA, ERG, IL3, HOXA9, ETV6

Compounds for genes affiliated with Mn1

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Mn1 according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6VDR
2pkh 24410.4KITLG, IL3
3serine4410.4EP300, VDR
4daniplestim4410.3IL3, KITLG
5mafosfamide4410.2KITLG, IL3
64-hydroperoxycyclophosphamide4410.2KITLG, IL3
7lomustine44 1111.2TP53, IL3
8pixy3214410.2KITLG, IL3
9amifostine44 1111.1TP53, KITLG, IL3
10ag-12964410.0KITLG, IL3
11melphalan44 1111.0TP53, BCL2L11, IL3
12carboplatin44 49 1111.9IL3, KITLG, TP53
13creatinine449.9IGFBP5, VDR, EP300, KITLG
14paclitaxel44 49 1111.8TP53, BCL2L11, IL3
15adriamycin449.8VDR, EP300, IL3, TP53
16etoposide44 49 59 1112.8EP300, IL3, BCL2L11, TP53
17hydroxyurea44 49 1111.8IL3, KITLG, TP53
18vitamin d449.7IGFBP5, VDR, EP300, IL3
19pd 98,059449.7IGFBP5, EP300, IL3, KITLG, BCL2L11
20calcitriol44 59 11 2412.7IGFBP5, VDR, EP300, IL3, KITLG
215fluorouracil449.7VDR, IL3, KITLG, TP53
22sb 20358044 5910.7VDR, EP300, BCL2L11, TP53
23imatinib44 49 1111.7BCL2L11, KITLG, IL3, ETV6
24depsipeptide449.7EP300, IL3, KITLG, BCL2L11, TP53
25doxorubicin44 49 1111.6EP300, IL3, KITLG, NOTCH1, TP53
26wortmannin449.6KITLG, IL3, EP300, IGFBP5
27retinoid449.6VDR, EP300, PELP1, TP53
28cytarabine44 49 1111.6TP53, KITLG, IL3
29thymidine44 2410.5IGFBP5, VDR, IL3, KITLG, TP53
30rapamycin449.5IL3, KITLG, NOTCH1, BCL2L11
31steroid449.5VDR, EP300, SRA1
32phosphatidylinositol449.5IGFBP5, EP300, IL3, KITLG, NOTCH1, BCL2L11
33actinomycin d449.4VDR, EP300, IL3, KITLG, BCL2L11, TP53
34cycloheximide449.4IGFBP5, VDR, IL3, KITLG, BCL2L11, TP53
35dexamethasone44 49 28 1112.3IGFBP5, VDR, IL3, KITLG, NOTCH1, BCL2L11
36testosterone44 59 11 2412.3IGFBP5, VDR, EP300, IL3, KITLG, PELP1
37ly294002449.2IGFBP5, EP300, IL3, KITLG, NOTCH1, BCL2L11
38vegf449.2IGFBP5, ETV6, EP300, KITLG, NOTCH1, TP53
39tamoxifen44 49 28 1112.1IGFBP5, VDR, EP300, IL3, SRA1, PELP1
40alanine449.1IGFBP5, VDR, EP300, IL3, KITLG, PELP1
41tyrosine448.3IGFBP5, ETV6, EP300, HOXA9, IL3, KITLG
42retinoic acid44 248.8IGFBP5, VDR, MN1, ETV6, EP300, IL3

GO Terms for genes affiliated with Mn1

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16Gene Ontology
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Cellular components related to Mn1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.1TP53, BAALC, MYBBP1A, VDR, ETV6, EP300

Biological processes related to Mn1 according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tube formationGO:03514810.3BCL2L11, NOTCH1
2positive regulation of keratinocyte differentiationGO:04561810.1VDR, NOTCH1
3cellular response to glucose starvationGO:04214910.0TP53, MYBBP1A
4lung developmentGO:03032410.0CEBPA, NOTCH1, EP300
5intrinsic apoptotic signaling pathway by p53 class mediatorGO:0723329.9TP53, MYBBP1A
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8TP53, KITLG, IL3
7positive regulation of cell cycle arrestGO:0711589.7MYBBP1A, TP53
8in utero embryonic developmentGO:0017019.6MECOM, NOTCH1, BCL2L11, TP53
9negative regulation of transcription, DNA-dependentGO:0458929.4MECOM, MYBBP1A, VDR, NOTCH1, TP53
10negative regulation of transcription from RNA polymerase II promoterGO:0001229.3VDR, EP300, NOTCH1, CEBPA, TP53
11cell proliferationGO:0082839.2TP53, ERG, SRA1, KITLG
12positive regulation of transcription from RNA polymerase II promoterGO:0459449.1TP53, MECOM, VDR, EP300, NOTCH1, SRA1
13transcription, DNA-dependentGO:0063517.9MECOM, MYBBP1A, ETV6, EP300, HOXA9, SRA1

Molecular functions related to Mn1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.2MYBBP1A, EP300, CEBPA, TP53
2DNA bindingGO:0036778.5TP53, CEBPA, ERG, SRA1, EP300, VDR
3sequence-specific DNA bindingGO:0435658.3CEBPA, MYBBP1A, VDR, ETV6, HOXA9, NOTCH1
4sequence-specific DNA binding transcription factor activityGO:0037007.8MECOM, VDR, ETV6, HOXA9, NOTCH1, ERG
5protein bindingGO:0055156.1EP300, ETV6, VDR, MYBBP1A, IGFBP5, MECOM

Products for genes affiliated with Mn1

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Sources for Mn1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet