MN1
MCID: MN1001
MIFTS: 21

Mn1 (MN1) malady

Rare diseases category
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Summaries for Mn1

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33MalaCards
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MalaCards: Mn1, also known as meningioma 1 gene, is related to leukemia and meningioma. An important gene associated with Mn1 is SRA1 (steroid receptor RNA activator 1). The compound estrogen have been mentioned in the context of this disorder. Affiliated tissues include myeloid and bone.

Aliases & Classifications for Mn1

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43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

mn1 43
meningioma 1 gene 43


Related Diseases for Mn1

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17GeneCards, 18GeneDecks
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Diseases related to Mn1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.7BAALC, BCL2L11, CEBPA
2meningioma10.7
3acute myeloid leukemia10.5
4myeloid leukemia10.5
5cytogenetically normal acute myeloid leukemia10.2
6myelodysplastic syndromes10.2
7refractory anemia10.1
8acute leukemia10.0CEBPA
9neurofibromatosis10.0
10cleft palate10.0
11pierre robin sequence10.0
12myeloproliferative disorder10.0

Graphical network of diseases related to Mn1:



Diseases related to mn1

Symptoms for Mn1

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Drugs & Therapeutics for Mn1

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Mn1

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Anatomical Context for Mn1

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33MalaCards
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MalaCards organs/tissues related to Mn1:

33
Myeloid, Bone

Animal Models for Mn1 or affiliated genes

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Publications for Mn1

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52PubMed
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Articles related to Mn1:

(show all 31)
idTitleAuthorsYear
1
Mapping of MN1 sequences necessary for myeloid transformation. (23626719)
2013
2
Proteomic comparison of basal endosperm in maize miniature1 mutant and its wild-type Mn1. (23805148)
2013
3
Meningioma 1 (MN1) expression: refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML). (23394438)
2013
4
The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. (23515710)
2013
5
Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. (22436304)
2012
6
Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. (22488406)
2012
7
Pleiotropy and its dissection through a metabolic gene Miniature1 (Mn1) that encodes a cell wall invertase in developing seeds of maize. (22284709)
2012
8
Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia. (22072540)
2012
9
Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction. (22905229)
2012
10
Structural characterization and surface activities of biogenic rhamnolipid surfactants from Pseudomonas aeruginosa isolate MN1 and synergistic effects against methicillin-resistant Staphylococcus aureus. (22644668)
2012
11
Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1. (21965128)
2012
12
Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. (21828125)
2011
13
Sugar-hormone cross-talk in seed development: two redundant pathways of IAA biosynthesis are regulated differentially in the invertase-deficient miniature1 (mn1) seed mutant in maize. (20924026)
2010
14
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. (20096329)
2010
15
Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. (19451432)
2009
16
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. (19752345)
2009
17
MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. (18632758)
2008
18
The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. (18948418)
2008
19
MN1, a novel player in human AML. (17698380)
2007
20
The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. (17242174)
2007
21
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. (17494859)
2007
22
MN1 overexpression is an important step in the development of inv(16) AML. (17525718)
2007
23
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. (16912223)
2006
24
The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. (15890672)
2005
25
Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. (15870292)
2005
26
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia. (15334551)
2004
27
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. (12569362)
2003
28
TEL and MN1 fusion in myelodysplastic syndrome: new evidence for a therapy-related event. (10931009)
2000
29
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. (7731705)
1995
30
Method of identification of the NMR origin in magnetically ordered substances: Application to the Mn1+ delta Sb alloy system. (9979678)
1995
31
Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. (7731706)
1995

Variations for Mn1

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Expression for genes affiliated with Mn1

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mn1

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Pathways for genes affiliated with Mn1

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Compounds for genes affiliated with Mn1

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45Novoseek
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Compounds related to Mn1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen458.9BCL2L11, SRA1, CEBPA

GO Terms for genes affiliated with Mn1

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16Gene Ontology
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Molecular functions related to Mn1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.0CEBPA, MYBBP1A

Products for genes affiliated with Mn1

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Sources for Mn1

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet