MN1
MCID: MN1001
MIFTS: 33

Mn1 (MN1) malady

Summaries for Mn1

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33MalaCards
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MalaCards: Mn1, also known as meningioma 1 gene, is related to acute leukemia and myelodysplastic syndromes. An important gene associated with Mn1 is SRA1 (steroid receptor RNA activator 1), and among its related pathways are C-MYB transcription factor network and Development IGF-RI signaling. The compounds estrogen and pkh 2 have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Mn1

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

mn1 43
meningioma 1 gene 43


Related Diseases for Mn1

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mn1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia30.7ETV6, HOXA9, IL3, KITLG, NOTCH1, CEBPA
2myelodysplastic syndromes30.2MECOM, VDR, ETV6, EP300, HOXA9, IL3
3myeloproliferative disorder30.1KITLG, IL3, ETV6
4acute myeloid leukemia10.5
5cleft palate10.1
6t-cell leukemia10.1
7acute myeloid leukemia, adult10.1
8refractory anemia with excess blasts10.1
9refractory anemia10.1
10acute monocytic leukemia10.0EP300
11prostatitis10.0VDR
12dyskeratosis congenita10.0KITLG
13hyperparathyroidism10.0VDR
14pancreatitis10.0KITLG
15leukemoid reaction10.0IL3
16lung cancer10.0TP53
17neuroblastoma10.0TP53
18graves' disease10.0VDR
19liposarcoma10.0TP53
20kidney cancer10.0TP53
21multiple myeloma10.0TP53
22wilms tumor10.0NOTCH1
23meningioma10.0SRA1, MN1
24fanconi's anemia10.0KITLG, IL3
25deficiency anemia10.0KITLG, IL3
26severe combined immunodeficiency10.0IL3, KITLG
27thrombocytosis10.0KITLG, IL3
28fibrosarcoma10.0ETV6, EP300
29severe congenital neutropenia10.0KITLG, IL3
30arthritis10.0VDR
31psoriasis10.0VDR
32down syndrome10.0ETV6, ERG
33endometrial carcinoma10.0TP53, EP300
34polycythemia vera10.0IL3, KITLG
35precursor b-cell acute lymphoblastic leukemia10.0KITLG, IL3, ETV6
36skin cancer10.0TP53, VDR
37erythrocytosis10.0KITLG, IL3
38glioblastoma multiforme10.0TP53, BCL2L11, IGFBP5
39peripheral primitive neuroectodermal tumor10.0EP300, KITLG, ERG
40nephroblastoma10.0TP53, MECOM
41myeloma10.0BCL2L11, NOTCH1, KITLG, IL3
42cervical cancer10.0TP53, NOTCH1, EP300
43precursor t-cell acute lymphoblastic leukemia10.0ETV6, IL3, NOTCH1
44pancreatic cancer10.0VDR, NOTCH1, BCL2L11, TP53
45adenoma10.0IGFBP5, VDR, KITLG, TP53
46chronic myeloid leukemia10.0MECOM, ETV6, HOXA9, IL3, KITLG
47retinoblastoma10.0IGFBP5, VDR, EP300, CEBPA, TP53
48non-hodgkin lymphoma10.0VDR, ETV6, IL3, KITLG, NOTCH1
49colorectal cancer10.0TP53, KITLG, EP300, VDR
50adenocarcinoma10.0IGFBP5, EP300, KITLG, NOTCH1, TP53

Graphical network of the top 20 diseases related to Mn1:



Diseases related to mn1

Clinical Features for Mn1

Drugs & Therapeutics for Mn1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mn1

Anatomical Context for Mn1

Animal Models for Mn1 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Mn1:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.4MYBBP1A
2MP:00053719.6MECOM, HOXA9, BCL2L11
3MP:00053889.2MECOM, MN1, EP300, NOTCH1, TP53
4MP:00053909.1MN1, HOXA9, KITLG, NOTCH1, LARGE
5MP:00053779.1MECOM, VDR, KITLG, NOTCH1, LARGE, BCL2L11
6MP:00053698.7MECOM, IGFBP5, VDR, EP300, NOTCH1, LARGE
7MP:00036318.5MECOM, VDR, KITLG, LARGE, ERG
8MP:00053828.5MECOM, VDR, MN1, EP300, KITLG, NOTCH1
9MP:00107718.3VDR, ETV6, HOXA9, KITLG, NOTCH1, BCL2L11
10MP:00028738.2TP53, CEBPA, BCL2L11, ERG, NOTCH1, ETV6
11MP:00053818.2VDR, MN1, ETV6, EP300, KITLG, NOTCH1
12MP:00053898.2MECOM, VDR, HOXA9, KITLG, LARGE, BCL2L11
13MP:00020068.1TP53, MECOM, MN1, ETV6, EP300, IL3
14MP:00053798.0IGFBP5, VDR, ETV6, HOXA9, IL3, KITLG
15MP:00053847.5MECOM, VDR, ETV6, EP300, IL3, KITLG
16MP:00053857.5MECOM, VDR, ETV6, EP300, KITLG, NOTCH1
17MP:00053977.2MECOM, VDR, ETV6, EP300, HOXA9, IL3
18MP:00053787.0EP300, ETV6, VDR, IGFBP5, MECOM, HOXA9
19MP:00053876.9HOXA9, EP300, ETV6, VDR, MECOM, IL3
20MP:00053766.8EP300, ETV6, MN1, VDR, IGFBP5, MECOM
21MP:00107686.7EP300, ETV6, MN1, VDR, MYBBP1A, MECOM

Publications for Mn1

Sources:
51PubMed
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Articles related to Mn1:

idTitleAuthorsYear
1
Mn4, Mn6, and Mn11 clusters from the use of bulky diphenyl(pyridine-2-yl)methanol. (19728691)
2009
2
Wheel-shaped [Mn12] single-molecule magnets. (15819561)
2005
3
Single-molecule magnets: a reductive aggregation route to new types of Mn12 complexes. (16296819)
2005
4
Mn12O12(OMe)2(O2CPh)16(H2O)2]2- single-molecule magnets and other manganese compounds from a reductive aggregation procedure. (16124812)
2005
5
Single-molecule magnets: site-specific ligand abstraction from [Mn12O12(O2CR)16(H2O)4] and the preparation and properties of [Mn12O12(NO3)4(O2CCH2Bu(t))12(H2O)4]. (11487323)
2001
6
Single-molecule magnets: Jahn-Teller isomerism and the origin of two magnetization relaxation processes in Mn12 complexes. (11304159)
2001

Genetic Variations for Mn1

Expression for genes affiliated with Mn1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mn1

Search GEO for disease gene expression data for Mn1.

Pathways for genes affiliated with Mn1

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology, 52QIAGEN
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Pathways related to Mn1 according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8EP300, KITLG, CEBPA
2
Hide members
9.7TP53, BCL2L11, IGFBP5
39.7IGFBP5, IL3, TP53
4
Hide members
9.7EP300, NOTCH1, TP53
59.5CEBPA, KITLG, IL3, MECOM
69.4TP53, BCL2L11, KITLG, IL3
79.3VDR, EP300, HOXA9, TP53
8
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9.3EP300, IL3, KITLG, CEBPA, TP53
9
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9.2TP53, BCL2L11, KITLG, IL3, EP300
109.2TP53, CEBPA, KITLG, EP300, MECOM
11
Hide members
9.0EP300, IL3, KITLG, NOTCH1, BCL2L11, TP53
128.9MIR181B2, EP300, NOTCH1, BCL2L11, TP53
13
Hide members
8.6EP300, IL3, KITLG, NOTCH1, SRA1, PELP1
148.4TP53, CEBPA, ERG, IL3, HOXA9, ETV6

Compounds for genes affiliated with Mn1

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Mn1 according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6VDR
2pkh 24510.4KITLG, IL3
3serine4510.4EP300, VDR
4daniplestim4510.3IL3, KITLG
5mafosfamide4510.2KITLG, IL3
64-hydroperoxycyclophosphamide4510.2KITLG, IL3
7lomustine45 1111.2TP53, IL3
8pixy3214510.2KITLG, IL3
9amifostine45 1111.1TP53, KITLG, IL3
10ag-12964510.0KITLG, IL3
11melphalan45 1111.0TP53, BCL2L11, IL3
12carboplatin45 50 1111.9IL3, KITLG, TP53
13creatinine459.9IGFBP5, VDR, EP300, KITLG
14paclitaxel45 50 1111.8TP53, BCL2L11, IL3
15adriamycin459.8VDR, EP300, IL3, TP53
16etoposide45 50 60 1112.8EP300, IL3, BCL2L11, TP53
17hydroxyurea45 50 1111.8IL3, KITLG, TP53
18vitamin d459.7IGFBP5, VDR, EP300, IL3
19pd 98,059459.7IGFBP5, EP300, IL3, KITLG, BCL2L11
20calcitriol45 60 11 2412.7IGFBP5, VDR, EP300, IL3, KITLG
215fluorouracil459.7VDR, IL3, KITLG, TP53
22sb 20358045 6010.7VDR, EP300, BCL2L11, TP53
23imatinib45 50 1111.7BCL2L11, KITLG, IL3, ETV6
24depsipeptide459.7EP300, IL3, KITLG, BCL2L11, TP53
25doxorubicin45 50 1111.6EP300, IL3, KITLG, NOTCH1, TP53
26wortmannin459.6KITLG, IL3, EP300, IGFBP5
27retinoid459.6VDR, EP300, PELP1, TP53
28cytarabine45 50 1111.6TP53, KITLG, IL3
29thymidine45 2410.5IGFBP5, VDR, IL3, KITLG, TP53
30rapamycin459.5IL3, KITLG, NOTCH1, BCL2L11
31steroid459.5VDR, EP300, SRA1
32phosphatidylinositol459.5IGFBP5, EP300, IL3, KITLG, NOTCH1, BCL2L11
33actinomycin d459.4VDR, EP300, IL3, KITLG, BCL2L11, TP53
34cycloheximide459.4IGFBP5, VDR, IL3, KITLG, BCL2L11, TP53
35dexamethasone45 50 29 1112.3IGFBP5, VDR, IL3, KITLG, NOTCH1, BCL2L11
36testosterone45 60 11 2412.3IGFBP5, VDR, EP300, IL3, KITLG, PELP1
37ly294002459.2IGFBP5, EP300, IL3, KITLG, NOTCH1, BCL2L11
38vegf459.2IGFBP5, ETV6, EP300, KITLG, NOTCH1, TP53
39tamoxifen45 50 29 1112.1IGFBP5, VDR, EP300, IL3, SRA1, PELP1
40alanine459.1IGFBP5, VDR, EP300, IL3, KITLG, PELP1
41tyrosine458.3IGFBP5, ETV6, EP300, HOXA9, IL3, KITLG
42retinoic acid45 248.8IGFBP5, VDR, MN1, ETV6, EP300, IL3

GO Terms for genes affiliated with Mn1

Sources:
16Gene Ontology
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Cellular components related to Mn1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.1TP53, BAALC, MYBBP1A, VDR, ETV6, EP300

Biological processes related to Mn1 according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tube formationGO:03514810.3BCL2L11, NOTCH1
2positive regulation of keratinocyte differentiationGO:04561810.1VDR, NOTCH1
3cellular response to glucose starvationGO:04214910.0TP53, MYBBP1A
4lung developmentGO:03032410.0CEBPA, NOTCH1, EP300
5intrinsic apoptotic signaling pathway by p53 class mediatorGO:0723329.9TP53, MYBBP1A
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8TP53, KITLG, IL3
7positive regulation of cell cycle arrestGO:0711589.7MYBBP1A, TP53
8in utero embryonic developmentGO:0017019.6MECOM, NOTCH1, BCL2L11, TP53
9negative regulation of transcription, DNA-dependentGO:0458929.4MECOM, MYBBP1A, VDR, NOTCH1, TP53
10negative regulation of transcription from RNA polymerase II promoterGO:0001229.3VDR, EP300, NOTCH1, CEBPA, TP53
11cell proliferationGO:0082839.2TP53, ERG, SRA1, KITLG
12positive regulation of transcription from RNA polymerase II promoterGO:0459449.1TP53, MECOM, VDR, EP300, NOTCH1, SRA1
13transcription, DNA-dependentGO:0063517.9MECOM, MYBBP1A, ETV6, EP300, HOXA9, SRA1

Molecular functions related to Mn1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.2MYBBP1A, EP300, CEBPA, TP53
2DNA bindingGO:0036778.5TP53, CEBPA, ERG, SRA1, EP300, VDR
3sequence-specific DNA bindingGO:0435658.3CEBPA, MYBBP1A, VDR, ETV6, HOXA9, NOTCH1
4sequence-specific DNA binding transcription factor activityGO:0037007.8MECOM, VDR, ETV6, HOXA9, NOTCH1, ERG
5protein bindingGO:0055156.1EP300, ETV6, VDR, MYBBP1A, IGFBP5, MECOM

Products for genes affiliated with Mn1

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mn1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet