MN1
MCID: MN1001
MIFTS: 30

Mn1 (MN1) malady

Categories: Rare diseases

Aliases & Classifications for Mn1

Aliases & Descriptions for Mn1:

Name: Mn1 50
Meningioma 1 Gene 50

Classifications:



Summaries for Mn1

MalaCards based summary : Mn1, also known as meningioma 1 gene, is related to meningioma, familial and urethral syndrome. An important gene associated with Mn1 is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator), and among its related pathways/superpathways are Tuberculosis and Direct p53 effectors. The drugs Copper and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and b cells, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Mn1

Graphical network of the top 20 diseases related to Mn1:



Diseases related to Mn1

Symptoms & Phenotypes for Mn1

MGI Mouse Phenotypes related to Mn1:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.67 EP300 ETV6 MN1 VDR
2 growth/size/body region MP:0005378 9.65 EP300 ETV6 FLT3 MN1 VDR
3 endocrine/exocrine gland MP:0005379 9.62 ETV6 FLT3 VDR EP300
4 homeostasis/metabolism MP:0005376 9.55 EP300 ETV6 FLT3 MN1 VDR
5 mortality/aging MP:0010768 9.35 EP300 ETV6 FLT3 MN1 VDR
6 neoplasm MP:0002006 8.92 EP300 ETV6 FLT3 MN1

Drugs & Therapeutics for Mn1

Drugs for Mn1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Copper Approved Phase 1 15158-11-9, 7440-50-8 27099
2
Hydroxocobalamin Approved Phase 1 13422-51-0 11953898 5460373 44475014
3
Iron Approved Phase 1 7439-89-6 23925
4
Selenium Approved, Vet_approved Phase 1 7782-49-2
5
Zinc Approved Phase 1 7440-66-6 32051 23994
6
Cyanocobalamin Approved, Nutraceutical Phase 1 68-19-9 44176380
7
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
9
leucovorin Approved, Nutraceutical Phase 1 58-05-9 54575, 6560146 143
10
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
11
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
12
Pyridoxal Approved, Nutraceutical Phase 1 66-72-8 1050
13
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 1 65-23-6 1054
14
Riboflavin Approved, Nutraceutical, Vet_approved Phase 1 83-88-5 493570
15
Thiamine Approved, Nutraceutical, Vet_approved Phase 1 59-43-8 1130
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 11103-57-4, 68-26-8 445354
17
Vitamin C Approved, Nutraceutical Phase 1 50-81-7 5785 54670067
18
Vitamin E Approved, Nutraceutical, Vet_approved Phase 1 59-02-9 14985
19 Antimetabolites Phase 1
20 Antioxidants Phase 1
21 Bone Density Conservation Agents Phase 1
22 cadexomer iodine Phase 1
23 Dermatologic Agents Phase 1
24 Ergocalciferols Phase 1
25 Hematinics Phase 1
26 Hypolipidemic Agents Phase 1
27
Iodine Phase 1 7553-56-2 807
28 Lipid Regulating Agents Phase 1
29 Micronutrients Phase 1
30 Nicotinic Acids Phase 1
31 Photosensitizing Agents Phase 1
32 Protective Agents Phase 1
33 Retinol palmitate Phase 1
34 Tocopherols Phase 1
35 Tocotrienols Phase 1
36 Trace Elements Phase 1
37 Vasodilator Agents Phase 1
38 Vitamin B 12 Phase 1
39 Vitamin B 6 Phase 1
40 Vitamin B Complex Phase 1
41 vitamin d Phase 1
42 Vitamins Phase 1
43 Calciferol Nutraceutical Phase 1
44
Cobalamin Nutraceutical Phase 1 13408-78-1 6438156
45 Folate Nutraceutical Phase 1
46 Iron Supplement Nutraceutical Phase 1
47
Methylcobalamin Experimental, Nutraceutical Phase 1 13422-55-4
48 retinol Nutraceutical Phase 1
49 Thiamin Nutraceutical Phase 1
50 Tocopherol Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome Completed NCT00168688 Phase 1
2 Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Sclerosis Suspended NCT01082653 Phase 1
3 General Practitioner-performed Compression Ultrasound for Deep Vein Thrombosis Completed NCT02114983
4 OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation Completed NCT00439127
5 Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia Active, not recruiting NCT00900224

Search NIH Clinical Center for Mn1

Genetic Tests for Mn1

Anatomical Context for Mn1

MalaCards organs/tissues related to Mn1:

39
Myeloid, Bone, B Cells

Publications for Mn1

Articles related to Mn1:

(show all 41)
id Title Authors Year
1
MN1 and PTEN gene expression in acute myeloid leukemia. ( 27983532 )
2016
2
Variable but consistent pattern of Meningioma 1 gene (MN1) expression in different genetic subsets of acute myelogenous leukaemia and its potential use as a marker for minimal residual disease detection. ( 27765915 )
2016
3
Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies. ( 26545049 )
2015
4
Chromosome 22q12.1 microdeletions: confirmation of the MN1 gene as a candidate gene for cleft palate. ( 25944382 )
2015
5
Craniofacial abnormalities and developmental delay in two families with overlapping 22q12.1 microdeletions involving the MN1 gene. ( 25810350 )
2015
6
High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells. ( 26111797 )
2015
7
Cell Fate Decisions in Malignant Hematopoiesis: Leukemia Phenotype Is Determined by Distinct Functional Domains of the MN1 Oncogene. ( 25401736 )
2014
8
Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes. ( 25549701 )
2014
9
A comparative glycoproteome study of developing endosperm in the hexose-deficient miniature1 (mn1) seed mutant and its wild type Mn1 in maize. ( 24616729 )
2014
10
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. ( 25339361 )
2014
11
Proteomic comparison of basal endosperm in maize miniature1 mutant and its wild-type Mn1. ( 23805148 )
2013
12
Mapping of MN1 sequences necessary for myeloid transformation. ( 23626719 )
2013
13
Meningioma 1 (MN1) expression: refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML). ( 23394438 )
2013
14
The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. ( 23515710 )
2013
15
Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. ( 22488406 )
2012
16
Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction. ( 22905229 )
2012
17
Pleiotropy and its dissection through a metabolic gene Miniature1 (Mn1) that encodes a cell wall invertase in developing seeds of maize. ( 22284709 )
2012
18
Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1. ( 21965128 )
2012
19
Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia. ( 22072540 )
2012
20
Structural characterization and surface activities of biogenic rhamnolipid surfactants from Pseudomonas aeruginosa isolate MN1 and synergistic effects against methicillin-resistant Staphylococcus aureus. ( 22644668 )
2012
21
Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. ( 22436304 )
2012
22
Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. ( 21828125 )
2011
23
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. ( 20096329 )
2010
24
Sugar-hormone cross-talk in seed development: two redundant pathways of IAA biosynthesis are regulated differentially in the invertase-deficient miniature1 (mn1) seed mutant in maize. ( 20924026 )
2010
25
Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. ( 19451432 )
2009
26
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. ( 19752345 )
2009
27
MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. ( 18632758 )
2008
28
The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. ( 18948418 )
2008
29
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. ( 17494859 )
2007
30
MN1 overexpression is an important step in the development of inv(16) AML. ( 17525718 )
2007
31
MN1, a novel player in human AML. ( 17698380 )
2007
32
The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. ( 17242174 )
2007
33
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. ( 16912223 )
2006
34
The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. ( 15890672 )
2005
35
Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. ( 15870292 )
2005
36
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia. ( 15334551 )
2004
37
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. ( 12569362 )
2003
38
TEL and MN1 fusion in myelodysplastic syndrome: new evidence for a therapy-related event. ( 10931009 )
2000
39
Method of identification of the NMR origin in magnetically ordered substances: Application to the Mn1+ delta Sb alloy system. ( 9979678 )
1995
40
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. ( 7731705 )
1995
41
Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. ( 7731706 )
1995

Variations for Mn1

Expression for Mn1

Search GEO for disease gene expression data for Mn1.

Pathways for Mn1

Pathways related to Mn1 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.51 EP300 VDR
2 11.28 EP300 VDR
3 10.84 EP300 VDR
4 10.14 EP300 ETV6 FLT3

GO Terms for Mn1

Biological processes related to Mn1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.56 EP300 ETV6 MN1 VDR
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.33 EP300 ETV6 VDR
3 animal organ morphogenesis GO:0009887 8.96 EP300 VDR
4 B cell differentiation GO:0030183 8.62 EP300 FLT3

Sources for Mn1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....