Aliases & Classifications for Mn1

MalaCards integrated aliases for Mn1:

Name: Mn1 49
Meningioma 1 Gene 49

Classifications:



Summaries for Mn1

MalaCards based summary : Mn1, also known as meningioma 1 gene, is related to leukemia, acute myeloid and meningioma, familial. An important gene associated with Mn1 is MN1 (MN1 Proto-Oncogene, Transcriptional Regulator), and among its related pathways/superpathways are Tuberculosis and Direct p53 effectors. The drugs Zinc and Iron have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and b cells, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Mn1

Graphical network of the top 20 diseases related to Mn1:



Diseases related to Mn1

Symptoms & Phenotypes for Mn1

MGI Mouse Phenotypes related to Mn1:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.67 EP300 ETV6 MN1 VDR
2 growth/size/body region MP:0005378 9.65 EP300 ETV6 FLT3 MN1 VDR
3 endocrine/exocrine gland MP:0005379 9.62 EP300 ETV6 FLT3 VDR
4 homeostasis/metabolism MP:0005376 9.55 EP300 ETV6 FLT3 MN1 VDR
5 mortality/aging MP:0010768 9.35 VDR EP300 ETV6 FLT3 MN1
6 neoplasm MP:0002006 8.92 EP300 ETV6 FLT3 MN1

Drugs & Therapeutics for Mn1

Drugs for Mn1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 1 7440-66-6 32051 23994
2
Iron Approved Phase 1 7439-89-6 23925
3
Copper Approved, Investigational Phase 1 7440-50-8 27099
4
Selenium Approved, Investigational, Vet_approved Phase 1 7782-49-2
5
Iodine Approved, Investigational Phase 1 7553-56-2 807
6
Hydroxocobalamin Approved Phase 1 13422-51-0 5460373 44475014 11953898
7
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 1 65-23-6 1054
8
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
9
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 68-26-8, 11103-57-4 445354
10
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
11
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 1 83-88-5 493570
12
Vitamin C Approved, Nutraceutical Phase 1 50-81-7 54670067 5785
13
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
14
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
15
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 1 59-43-8 1130
16
Pyridoxal Approved, Nutraceutical Phase 1 66-72-8 1050
17 Tocopherol Approved, Investigational, Nutraceutical Phase 1
18
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 1 13422-55-4
19
Cyanocobalamin Approved, Nutraceutical Phase 1 68-19-9 44176380
20
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
22
Vitamin E Approved, Nutraceutical, Vet_approved Phase 1 59-02-9 14985
23 cadexomer iodine Phase 1
24 Retinol palmitate Phase 1
25 Micronutrients Phase 1
26 Tocopherols Phase 1
27 Tocotrienols Phase 1
28 Trace Elements Phase 1
29 Hematinics Phase 1
30 Nicotinic Acids Phase 1
31 Vasodilator Agents Phase 1
32 Dermatologic Agents Phase 1
33 Vitamin B 12 Phase 1
34 Vitamin B 6 Phase 1
35 Vitamin B Complex Phase 1
36 Vitamins Phase 1
37 Ergocalciferols Phase 1
38 Hypolipidemic Agents Phase 1
39 Photosensitizing Agents Phase 1
40 Antimetabolites Phase 1
41 Protective Agents Phase 1
42 Lipid Regulating Agents Phase 1
43 Antioxidants Phase 1
44 Bone Density Conservation Agents Phase 1
45 Folate Nutraceutical Phase 1
46 Vitamin B12 Nutraceutical Phase 1
47 Tocotrienol Investigational, Nutraceutical Phase 1 6829-55-6
48
Cobalamin Nutraceutical Phase 1 13408-78-1 6438156
49 retinol Nutraceutical Phase 1
50 Vitamin B2 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome Completed NCT00168688 Phase 1
2 Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Sclerosis Suspended NCT01082653 Phase 1
3 General Practitioner-performed Compression Ultrasound for Deep Vein Thrombosis Completed NCT02114983
4 OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation Completed NCT00439127
5 Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia Active, not recruiting NCT00900224

Search NIH Clinical Center for Mn1

Genetic Tests for Mn1

Anatomical Context for Mn1

MalaCards organs/tissues related to Mn1:

38
Myeloid, Bone, B Cells

Publications for Mn1

Articles related to Mn1:

(show all 49)
# Title Authors Year
1
The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion. ( 29348602 )
2018
2
MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML. ( 28892045 )
2017
3
Electrochemical decolorization of methyl red by RuO2-IrO2-TiO2 electrode and biodegradation with Pseudomonas stutzeri MN1 and Acinetobacter baumannii MN3: An integrated approach. ( 28549326 )
2017
4
Dextransucrase Expression Is Concomitant with that of Replication and Maintenance Functions of the pMN1 Plasmid in<i>Lactobacillus sakei</i>MN1. ( 29209293 )
2017
5
The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients ( 28440611 )
2017
6
Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. ( 28990708 )
2017
7
The histone acetyltranseferase KAT8 regulates cell differentiation by suppression of MN1 in AML. ( 28516501 )
2017
8
Dextran production by Lactobacillus sakei MN1 coincides with reduced autoagglutination, biofilm formation and epithelial cell adhesion. ( 28457443 )
2017
9
Variable but consistent pattern of Meningioma 1 gene (MN1) expression in different genetic subsets of acute myelogenous leukaemia and its potential use as a marker for minimal residual disease detection. ( 27765915 )
2016
10
MN1 and PTEN gene expression in acute myeloid leukemia. ( 27983532 )
2016
11
Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies. ( 26545049 )
2015
12
High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells. ( 26111797 )
2015
13
Craniofacial abnormalities and developmental delay in two families with overlapping 22q12.1 microdeletions involving the MN1 gene. ( 25810350 )
2015
14
Chromosome 22q12.1 microdeletions: confirmation of the MN1 gene as a candidate gene for cleft palate. ( 25944382 )
2015
15
Cell Fate Decisions in Malignant Hematopoiesis: Leukemia Phenotype Is Determined by Distinct Functional Domains of the MN1 Oncogene. ( 25401736 )
2014
16
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. ( 25339361 )
2014
17
A comparative glycoproteome study of developing endosperm in the hexose-deficient miniature1 (mn1) seed mutant and its wild type Mn1 in maize. ( 24616729 )
2014
18
Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes. ( 25549701 )
2014
19
Proteomic comparison of basal endosperm in maize miniature1 mutant and its wild-type Mn1. ( 23805148 )
2013
20
Mapping of MN1 sequences necessary for myeloid transformation. ( 23626719 )
2013
21
Meningioma 1 (MN1) expression: refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML). ( 23394438 )
2013
22
The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. ( 23515710 )
2013
23
Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. ( 22488406 )
2012
24
Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia. ( 22072540 )
2012
25
Structural characterization and surface activities of biogenic rhamnolipid surfactants from Pseudomonas aeruginosa isolate MN1 and synergistic effects against methicillin-resistant Staphylococcus aureus. ( 22644668 )
2012
26
Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction. ( 22905229 )
2012
27
Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1. ( 21965128 )
2012
28
Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. ( 22436304 )
2012
29
Pleiotropy and its dissection through a metabolic gene Miniature1 (Mn1) that encodes a cell wall invertase in developing seeds of maize. ( 22284709 )
2012
30
Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. ( 21828125 )
2011
31
Sugar-hormone cross-talk in seed development: two redundant pathways of IAA biosynthesis are regulated differentially in the invertase-deficient miniature1 (mn1) seed mutant in maize. ( 20924026 )
2010
32
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. ( 20096329 )
2010
33
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. ( 19752345 )
2009
34
Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. ( 19451432 )
2009
35
MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. ( 18632758 )
2008
36
The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. ( 18948418 )
2008
37
MN1 overexpression is an important step in the development of inv(16) AML. ( 17525718 )
2007
38
MN1, a novel player in human AML. ( 17698380 )
2007
39
The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. ( 17242174 )
2007
40
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. ( 17494859 )
2007
41
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. ( 16912223 )
2006
42
Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. ( 15870292 )
2005
43
The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. ( 15890672 )
2005
44
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia. ( 15334551 )
2004
45
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. ( 12569362 )
2003
46
TEL and MN1 fusion in myelodysplastic syndrome: new evidence for a therapy-related event. ( 10931009 )
2000
47
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. ( 7731705 )
1995
48
Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. ( 7731706 )
1995
49
Method of identification of the NMR origin in magnetically ordered substances: Application to the Mn1+ delta Sb alloy system. ( 9979678 )
1995

Variations for Mn1

Expression for Mn1

Search GEO for disease gene expression data for Mn1.

Pathways for Mn1

Pathways related to Mn1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 EP300 VDR
2 11.28 EP300 VDR
3 10.84 EP300 VDR
4 10.14 EP300 ETV6 FLT3

GO Terms for Mn1

Biological processes related to Mn1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.56 EP300 ETV6 MN1 VDR
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.33 EP300 ETV6 VDR
3 animal organ morphogenesis GO:0009887 8.96 EP300 VDR
4 B cell differentiation GO:0030183 8.62 EP300 FLT3

Sources for Mn1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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