MCID: MDR006
MIFTS: 27

Moderate and Severe Traumatic Brain Injury malady

Rare diseases, Neuronal diseases categories

Summaries for Moderate and Severe Traumatic Brain Injury

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MalaCards based summary: Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is APOE (apolipoprotein E), and among its related pathways is A-beta Uptake and Degradation. The compounds sele and atenolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

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Sources:
48Orphanet, 27ICD10 via Orphanet
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Related Diseases for Moderate and Severe Traumatic Brain Injury

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Diseases related to Moderate and Severe Traumatic Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1brain injury10.7
2traumatic brain injury10.7
3head injury10.4
4alzheimer's disease10.1APOE
5stroke, ischemic10.0APOE, ACE
6nephrotic syndrome10.0APOE, ACE
7familial hyperlipidemia10.0APOE, ACE
8hypercholesterolemia10.0APOE, ACE
9diabetic nephropathy10.0APOE, ACE
10hypertension10.0APOE, ACE
11vascular disease10.0ACE, APOE
12coronary artery anomaly10.0ACE, APOE
13type 2 diabetes mellitus9.9ACE, APOE
14cerebrovascular disease9.9ACE, APOE
15myocardial infarction9.9APOE, ACE
16primary hyperoxaluria9.9ACE, APOE
17diabetes mellitus9.8ACE, APOE
18atherosclerosis9.8APOE, ACE

Graphical network of diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to moderate and severe traumatic brain injury

Symptoms for Moderate and Severe Traumatic Brain Injury

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Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

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Drug clinical trials:

Search ClinicalTrials for Moderate and Severe Traumatic Brain Injury

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

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Anatomical Context for Moderate and Severe Traumatic Brain Injury

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MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

32
Brain

Animal Models for Moderate and Severe Traumatic Brain Injury or affiliated genes

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MGI Mouse Phenotypes related to Moderate and Severe Traumatic Brain Injury:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1ACE, APOE
2MP:00053759.0ACE, APOE
3MP:00053708.8ACE, APOE

Publications for Moderate and Severe Traumatic Brain Injury

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Articles related to Moderate and Severe Traumatic Brain Injury:

idTitleAuthorsYear
1
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. (24139087)
2014
2
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. (24378157)
2013
3
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. (22511138)
2012
4
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. (16614010)
2006
5
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. (16525069)
2006

Variations for Moderate and Severe Traumatic Brain Injury

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Expression for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Expression patterns in normal tissues for genes affiliated with Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ACE, APOE

Compounds for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Sources:
44Novoseek, 50PharmGKB, 29IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1sele449.4ACE, APOE
2atenolol44 50 29 25 1213.4ACE, APOE
3warfarin44 50 25 1212.4ACE, APOE
4fluvastatin44 50 29 1212.3APOE, ACE
5losartan44 50 29 1212.3ACE, APOE
6pravastatin44 50 29 25 1213.3ACE, APOE
7atorvastatin44 50 29 25 1213.2APOE, ACE
8prostacyclin449.2ACE, APOE
9aspirin44 50 29 2512.1ACE, APOE
10cholesterol44 29 25 1212.1ACE, APOE
11acetylcholine44 50 29 25 1213.0APOE, ACE
12creatinine448.8ACE, APOE

GO Terms for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Cellular components related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ACE, APOE

Products for genes affiliated with Moderate and Severe Traumatic Brain Injury

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Moderate and Severe Traumatic Brain Injury

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet