MCID: MDR006
MIFTS: 23

Moderate and Severe Traumatic Brain Injury

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

Summaries for Moderate and Severe Traumatic Brain Injury

MalaCards based summary : Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drugs Mannitol and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Moderate and Severe Traumatic Brain Injury

Graphical network of the top 20 diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to Moderate and Severe Traumatic Brain Injury

Symptoms & Phenotypes for Moderate and Severe Traumatic Brain Injury

Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

Drugs for Moderate and Severe Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Citalopram Approved Phase 4 59729-33-8 2771
5 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
6 Adjuvants, Anesthesia Phase 4
7 GABA Agents Phase 4
8 GABA Modulators Phase 4
9 Neurotransmitter Agents Phase 4,Phase 2
10 Hemostatics Phase 4,Phase 3
11 Anesthetics Phase 4,Phase 3,Phase 2
12 Anesthetics, General Phase 4
13 Anesthetics, Intravenous Phase 4
14 Tranquilizing Agents Phase 4
15 Anti-Anxiety Agents Phase 4
16 Hypnotics and Sedatives Phase 4
17 Psychotropic Drugs Phase 4
18
Serotonin Phase 4,Phase 2 50-67-9 5202
19 Cholinergic Agents Phase 4,Phase 2
20 Muscarinic Antagonists Phase 4
21 Cholinergic Antagonists Phase 4
22 Serotonin Agents Phase 4,Phase 2
23 Serotonin Uptake Inhibitors Phase 4
24 Neurotransmitter Uptake Inhibitors Phase 4
25 Parasympatholytics Phase 4
26 Peripheral Nervous System Agents Phase 4,Phase 3
27 Antidepressive Agents Phase 4
28 Antidepressive Agents, Second-Generation Phase 4
29 Autonomic Agents Phase 4
30 Antiparkinson Agents Phase 4
31 Neuromuscular Blocking Agents Phase 4
32
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
33
Tranexamic Acid Approved Phase 3 1197-18-8 5526
34
Choline Approved, Nutraceutical Phase 3 62-49-7 305
35 Epoetin alfa Phase 3 113427-24-0
36 Analgesics Phase 3
37 calcium channel blockers Phase 3
38 Hematinics Phase 3,Phase 1,Phase 2
39 Tocolytic Agents Phase 3
40 Anti-Arrhythmia Agents Phase 3,Phase 2
41 Pharmaceutical Solutions Phase 3,Phase 2
42 Anticonvulsants Phase 3,Early Phase 1
43 Calcium, Dietary Phase 3
44 Coagulants Phase 3
45 Antifibrinolytic Agents Phase 3
46 Cytidine Diphosphate Choline Phase 3
47 Nootropic Agents Phase 3
48
Glyburide Approved Phase 2 10238-21-8 3488
49
Progesterone Approved, Vet_approved Phase 1, Phase 2 57-83-0 5994
50
Minocycline Approved, Investigational Phase 1, Phase 2 10118-90-8 5281021

Interventional clinical trials:

(show top 50) (show all 60)

id Name Status NCT ID Phase Drugs
1 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
2 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
3 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
4 Erythropoietin in Traumatic Brain Injury (EPO-TBI) Completed NCT00987454 Phase 3 Epoetin Alfa;Sodium Chloride 0.9%
5 Magnesium Sulfate For Brain Injury Completed NCT00004730 Phase 3 magnesium sulfate
6 Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury Recruiting NCT02794168 Phase 3 VAS203;Saline
7 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
8 Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury Not yet recruiting NCT02645552 Phase 3 Tranexamic Acid
9 Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) Terminated NCT00545662 Phase 3 Placebo;citicoline
10 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
11 Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury Terminated NCT00178711 Phase 3
12 Analysis of TCLT in TBI Patients: a Prospective, Randomized Controlled Trial Unknown status NCT02393079 Phase 2
13 Glyburide (RP-1127) for Traumatic Brain Injury (TBI) Unknown status NCT01454154 Phase 2 Glyburide;Placebo
14 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
15 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2 Allopregnanolone injection;Placebo injection
16 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Completed NCT01058395 Phase 1, Phase 2 Minocycline
17 Progesterone Treatment of Blunt Traumatic Brain Injury Completed NCT00048646 Phase 1, Phase 2 IV Progesterone
18 Telephone Intervention for Caregivers of Persons With Traumatic Brain Injury Completed NCT00692575 Phase 2
19 Transfusion Requirements After Head Trauma Completed NCT02203292 Phase 2
20 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
21 Effects of Huperzine A in Treatment of Moderate to Severe TBI Recruiting NCT01676311 Phase 2 Huperzine A;Placebo
22 Sumatriptan as Treatment for Post-traumatic Headache Recruiting NCT01854385 Phase 2 Sumatriptan 100 mg
23 Safe@Home: A Self-Management Program for Individuals With TBI and Their Families Active, not recruiting NCT02893345 Phase 2
24 IL-1ra Dose-range Study for Moderate-to-severe TBI Patients Not yet recruiting NCT02997371 Phase 2 Anakinra Prefilled Syringe;Isotonic saline
25 A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury. Terminated NCT00735085 Phase 2 SLV334;SLV334;SLV334;SLV334;Placebo
26 Early Propranolol After Traumatic Brain Injury: Phase II Terminated NCT01202110 Phase 2 Propranolol
27 The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects Active, not recruiting NCT03185507 Phase 1
28 Hormone Deficiency After Brain Injury During Combat Unknown status NCT01666964
29 Fatigue, Sleep Disorders and Endocrine Abnormalities in TBI Patients Unknown status NCT00775775
30 Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development Unknown status NCT00929045 Early Phase 1 Growth Hormone Replacement
31 Efficacy of Pharmacological Treatment of Working Memory Impairment After Traumatic Brain Injury: Evaluation With fMRI Unknown status NCT00489892 Modafinil
32 Normothermia Protocol for Traumatic Brain Injury Patients Unknown status NCT01354509
33 Imaging of Traumatic Brain Injury Unknown status NCT01196299
34 Study of Reserves After Traumatic Brain Injury Unknown status NCT01628003
35 Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury Completed NCT01955785
36 The Multicenter Italian INCEPT (INfarto CErebrale Post-Traumatico) Study Completed NCT02430324
37 Telephone Intervention After Traumatic Brain Injury Completed NCT00483522
38 Interacting Together Everyday: Recovery After Childhood Traumatic Brain Injury (TBI) "I-InTERACT Completed NCT01056146
39 Internet-based Interacting Together Everyday, Recovery After Childhood TBI (I-InTERACT)--RRTC Completed NCT01214694
40 Olfaction Disorders in Patients Included in The Trauma Brain Injury (TBI) Database at Trondheim University Hospital Completed NCT02565121 corticosteroids
41 Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury Recruiting NCT03169647
42 Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury Recruiting NCT01512524
43 Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury Recruiting NCT03307070
44 Long Term Effects of Erythropoietin in Patients With Moderate to Severe Traumatic Brain Injury Recruiting NCT03061565 erythropoietin;Placebos
45 HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial Recruiting NCT03260478
46 Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury Recruiting NCT02990078 Sildenafil citrate
47 Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe Recruiting NCT02333006
48 Cognitive Rehabilitation and Brain Activity of Attention Control in TBI Recruiting NCT02589509
49 Cholinesterase Activity and DeliriUm During Critical Illness Study Recruiting NCT03098472
50 The PIT-TBI Pilot Study Active, not recruiting NCT02480985

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

Anatomical Context for Moderate and Severe Traumatic Brain Injury

MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

39
Brain

Publications for Moderate and Severe Traumatic Brain Injury

Articles related to Moderate and Severe Traumatic Brain Injury:

id Title Authors Year
1
Characteristics of Moderate and Severe Traumatic Brain Injury of Motorcycle Crashes in Bandung, Indonesia. ( 28087431 )
2017
2
Management of Spasticity in Moderate and Severe Traumatic Brain Injury: Evaluation of Clinical Practice Guidelines. ( 27120291 )
2016
3
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. ( 24139087 )
2014
4
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. ( 24378157 )
2013
5
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. ( 22511138 )
2012
6
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. ( 16525069 )
2006
7
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. ( 16614010 )
2006

Variations for Moderate and Severe Traumatic Brain Injury

Expression for Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for Moderate and Severe Traumatic Brain Injury

Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.17 ACE APOE

GO Terms for Moderate and Severe Traumatic Brain Injury

Sources for Moderate and Severe Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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