MCID: MDR006
MIFTS: 23

Moderate and Severe Traumatic Brain Injury malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

Summaries for Moderate and Severe Traumatic Brain Injury

MalaCards based summary : Moderate and Severe Traumatic Brain Injury is related to traumatic brain injury and brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drugs Mannitol and Zinc have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Moderate and Severe Traumatic Brain Injury

Graphical network of the top 20 diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to Moderate and Severe Traumatic Brain Injury

Symptoms & Phenotypes for Moderate and Severe Traumatic Brain Injury

Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

Drugs for Moderate and Severe Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Zinc Approved Phase 4 7440-66-6 32051 23994
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Galantamine Approved Phase 4 357-70-0 9651 908828, 9651
6
Benzocaine Approved Phase 4,Phase 2 1994-09-7, 94-09-7 2337
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
9
Citalopram Approved Phase 4 59729-33-8 2771
10 tannic acid Approved, Nutraceutical Phase 4,Phase 2
11 insulin Phase 4,Early Phase 1
12 Cholinergic Agents Phase 4,Phase 2
13 Adjuvants, Anesthesia Phase 4
14 Cholinesterase Inhibitors Phase 4,Phase 2
15 GABA Agents Phase 4
16 GABA Modulators Phase 4
17 Neurotransmitter Agents Phase 4,Phase 2
18 Hemostatics Phase 4,Phase 3,Phase 2
19 Nootropic Agents Phase 4,Phase 3
20 Tranquilizing Agents Phase 4
21 Anesthetics Phase 4,Phase 3,Phase 2
22 Anesthetics, General Phase 4
23 Anesthetics, Intravenous Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 3
25 Anti-Anxiety Agents Phase 4
26 Hypnotics and Sedatives Phase 4
27 Hypoglycemic Agents Phase 4,Phase 2
28 Insulin, Globin Zinc Phase 4,Early Phase 1
29 Psychotropic Drugs Phase 4
30 Autonomic Agents Phase 4
31 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
32 Central Nervous System Stimulants Phase 4
33
Serotonin Phase 4,Phase 2 50-67-9 5202
34 Muscarinic Antagonists Phase 4
35 Cholinergic Antagonists Phase 4
36 Serotonin Agents Phase 4,Phase 2
37 Serotonin Uptake Inhibitors Phase 4
38 Neurotransmitter Uptake Inhibitors Phase 4
39 Parasympatholytics Phase 4
40 Dopamine Agents Phase 4
41 Dopamine Uptake Inhibitors Phase 4
42 Antidepressive Agents Phase 4
43 Antidepressive Agents, Second-Generation Phase 4
44 Antiparkinson Agents Phase 4
45 Neuromuscular Blocking Agents Phase 4
46
Ethanol Approved Phase 3 64-17-5 702
47
Progesterone Approved, Vet_approved Phase 3,Phase 1,Phase 2 57-83-0 5994
48
Tranexamic Acid Approved Phase 3,Phase 2 1197-18-8 5526
49
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
50
Choline Approved, Nutraceutical Phase 3 62-49-7 305

Interventional clinical trials:

(show top 50) (show all 85)
id Name Status NCT ID Phase
1 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4
2 Normoglycemia and Neurological Outcome Unknown status NCT01137773 Phase 4
3 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4
4 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4
5 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4
6 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
7 Acute Neurobehavioral Program for Improving Functional Status After TBI Unknown status NCT01166386 Phase 3
8 Erythropoietin in Traumatic Brain Injury (EPO-TBI) Completed NCT00987454 Phase 3
9 Magnesium Sulfate For Brain Injury Completed NCT00004730 Phase 3
10 Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury Completed NCT00755209 Phase 3
11 Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients Completed NCT02731495 Phase 2, Phase 3
12 Evaluation of Therapeutic Hypothermia in Convulsive Status EPILEPTICUS in Adults in Intensive Care Completed NCT01359332 Phase 3
13 Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury Recruiting NCT02794168 Phase 3
14 Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury Not yet recruiting NCT02645552 Phase 3
15 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Not yet recruiting NCT03143751 Phase 3
16 Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) Terminated NCT00545662 Phase 3
17 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
18 Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury Terminated NCT00178711 Phase 3
19 Progesterone for the Treatment of Traumatic Brain Injury III Terminated NCT00822900 Phase 3
20 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Unknown status NCT01058395 Phase 1, Phase 2
21 Analysis of TCLT in TBI Patients: a Prospective, Randomized Controlled Trial Unknown status NCT02393079 Phase 2
22 Glyburide (RP-1127) for Traumatic Brain Injury (TBI) Unknown status NCT01454154 Phase 2
23 Preventing Epilepsy After Traumatic Brain Injury With Topiramate Unknown status NCT00598923 Phase 2
24 TMS in the Treatment of the Sequelae of Closed Brain Injury Unknown status NCT00531258 Phase 2
25 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2
26 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2
27 Progesterone Treatment of Blunt Traumatic Brain Injury Completed NCT00048646 Phase 1, Phase 2
28 Telephone Intervention for Caregivers of Persons With Traumatic Brain Injury Completed NCT00692575 Phase 2
29 Transfusion Requirements After Head Trauma Completed NCT02203292 Phase 2
30 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2
31 Brain Training to Enhance Frontal Lobe Reasoning Completed NCT01552473 Phase 2
32 Study of NNZ-2566 in Patients With Traumatic Brain Injury Completed NCT00805818 Phase 2
33 Study of NNZ-2566 in Patients With Traumatic Brain Injury Under EFIC Completed NCT01366820 Phase 2
34 Repetitive Transcranial Magnetic Stimulation With Or Without Traumatic Stimuli in Post Traumatic Stress Disorder (PTSD) Completed NCT01196624 Phase 2
35 Effects of Huperzine A in Treatment of Moderate to Severe TBI Recruiting NCT01676311 Phase 2
36 Sumatriptan as Treatment for Post-traumatic Headache Recruiting NCT01854385 Phase 2
37 Safe@Home: A Self-Management Program for Individuals With TBI and Their Families Recruiting NCT02893345 Phase 2
38 Prehospital Tranexamic Acid Use for Traumatic Brain Injury Active, not recruiting NCT01990768 Phase 2
39 IL-1ra Dose-range Study for Moderate-to-severe TBI Patients Not yet recruiting NCT02997371 Phase 2
40 A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury. Terminated NCT00735085 Phase 2
41 Early Propranolol After Traumatic Brain Injury: Phase II Terminated NCT01202110 Phase 2
42 Safety Study of Umbilical Cord Blood To Treat Pediatric Traumatic Brain Injury Withdrawn NCT01251003 Phase 1, Phase 2
43 Hormone Deficiency After Brain Injury During Combat Unknown status NCT01666964
44 Fatigue, Sleep Disorders and Endocrine Abnormalities in TBI Patients Unknown status NCT00775775
45 Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development Unknown status NCT00929045 Early Phase 1
46 Efficacy of Pharmacological Treatment of Working Memory Impairment After Traumatic Brain Injury: Evaluation With fMRI Unknown status NCT00489892
47 Normothermia Protocol for Traumatic Brain Injury Patients Unknown status NCT01354509
48 Imaging of Traumatic Brain Injury Unknown status NCT01196299
49 Study of Reserves After Traumatic Brain Injury Unknown status NCT01628003
50 Augmentation of Cognitive Training in Children With TBI With D-Cyloserine Unknown status NCT02312635 Early Phase 1

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

Anatomical Context for Moderate and Severe Traumatic Brain Injury

MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

39
Brain

Publications for Moderate and Severe Traumatic Brain Injury

Articles related to Moderate and Severe Traumatic Brain Injury:

id Title Authors Year
1
Characteristics of Moderate and Severe Traumatic Brain Injury of Motorcycle Crashes in Bandung, Indonesia. ( 28087431 )
2017
2
Management of Spasticity in Moderate and Severe Traumatic Brain Injury: Evaluation of Clinical Practice Guidelines. ( 27120291 )
2016
3
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. ( 24139087 )
2014
4
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. ( 24378157 )
2013
5
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. ( 22511138 )
2012
6
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. ( 16614010 )
2006
7
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. ( 16525069 )
2006

Variations for Moderate and Severe Traumatic Brain Injury

Expression for Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for Moderate and Severe Traumatic Brain Injury

Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.17 ACE APOE

GO Terms for Moderate and Severe Traumatic Brain Injury

Sources for Moderate and Severe Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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