MCID: MDR006
MIFTS: 27

Moderate and Severe Traumatic Brain Injury malady

Neuronal diseases, Rare diseases categories
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Summaries for Moderate and Severe Traumatic Brain Injury

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33MalaCards
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MalaCards: Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is APOE (apolipoprotein E), and among its related pathways is A-beta Uptake and Degradation. The compounds sele and atenolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

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49Orphanet, 26ICD10 via Orphanet
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Related Diseases for Moderate and Severe Traumatic Brain Injury

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17GeneCards, 18GeneDecks
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Diseases related to Moderate and Severe Traumatic Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1brain injury10.7
2traumatic brain injury10.7
3head injury10.4
4alzheimer's disease10.0APOE
5stroke, ischemic10.0APOE, ACE
6nephrotic syndrome10.0APOE, ACE
7familial hyperlipidemia10.0APOE, ACE
8hypercholesterolemia10.0APOE, ACE
9diabetic nephropathy10.0APOE, ACE
10hypertension10.0APOE, ACE
11vascular disease10.0ACE, APOE
12coronary artery disease10.0ACE, APOE
13type 2 diabetes mellitus10.0ACE, APOE
14cerebrovascular disease10.0ACE, APOE
15myocardial infarction10.0APOE, ACE
16primary hyperoxaluria10.0ACE, APOE
17diabetes mellitus10.0ACE, APOE
18atherosclerosis9.9APOE, ACE

Graphical network of diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to moderate and severe traumatic brain injury

Symptoms for Moderate and Severe Traumatic Brain Injury

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Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

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Anatomical Context for Moderate and Severe Traumatic Brain Injury

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33MalaCards
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MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

33
Brain

Animal Models for Moderate and Severe Traumatic Brain Injury or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Moderate and Severe Traumatic Brain Injury:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1ACE, APOE
2MP:00053759.0ACE, APOE
3MP:00053708.8ACE, APOE

Publications for Moderate and Severe Traumatic Brain Injury

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52PubMed
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Articles related to Moderate and Severe Traumatic Brain Injury:

idTitleAuthorsYear
1
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. (24139087)
2014
2
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. (24378157)
2013
3
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. (22511138)
2012
4
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. (16614010)
2006
5
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. (16525069)
2006

Variations for Moderate and Severe Traumatic Brain Injury

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Expression for genes affiliated with Moderate and Severe Traumatic Brain Injury

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for genes affiliated with Moderate and Severe Traumatic Brain Injury

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50PathCards, 54R&D Systems
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Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ACE, APOE

Compounds for genes affiliated with Moderate and Severe Traumatic Brain Injury

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45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1sele459.4ACE, APOE
2atenolol45 51 29 24 1113.4ACE, APOE
3warfarin45 51 24 1112.4ACE, APOE
4fluvastatin45 51 29 1112.3APOE, ACE
5losartan45 51 29 1112.3ACE, APOE
6pravastatin45 51 29 24 1113.3ACE, APOE
7atorvastatin45 51 29 24 1113.2APOE, ACE
8prostacyclin459.2ACE, APOE
9aspirin45 51 29 2412.1ACE, APOE
10cholesterol45 29 24 1112.1ACE, APOE
11acetylcholine45 51 29 24 1113.0APOE, ACE
12creatinine458.8ACE, APOE

GO Terms for genes affiliated with Moderate and Severe Traumatic Brain Injury

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16Gene Ontology
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Cellular components related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ACE, APOE

Products for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Sources for Moderate and Severe Traumatic Brain Injury

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet