MCID: MDR006
MIFTS: 27

Moderate and Severe Traumatic Brain Injury malady

Neuronal diseases, Rare diseases categories

Summaries for Moderate and Severe Traumatic Brain Injury

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34MalaCards
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MalaCards: Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is APOE (apolipoprotein E), and among its related pathways is A-beta Uptake and Degradation. The compounds sele and atenolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

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50Orphanet, 27ICD10 via Orphanet
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Related Diseases for Moderate and Severe Traumatic Brain Injury

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18GeneCards, 19GeneDecks
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Diseases related to Moderate and Severe Traumatic Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1brain injury10.7
2traumatic brain injury10.7
3head injury10.4
4alzheimer's disease10.0APOE
5stroke, ischemic10.0APOE, ACE
6nephrotic syndrome10.0APOE, ACE
7familial hyperlipidemia10.0APOE, ACE
8hypercholesterolemia10.0APOE, ACE
9diabetic nephropathy10.0APOE, ACE
10hypertension10.0APOE, ACE
11vascular disease10.0ACE, APOE
12coronary artery disease10.0ACE, APOE
13type 2 diabetes mellitus10.0ACE, APOE
14cerebrovascular disease10.0ACE, APOE
15myocardial infarction10.0APOE, ACE
16primary hyperoxaluria10.0ACE, APOE
17diabetes mellitus10.0ACE, APOE
18atherosclerosis9.9APOE, ACE

Graphical network of diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to moderate and severe traumatic brain injury

Symptoms for Moderate and Severe Traumatic Brain Injury

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Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Moderate and Severe Traumatic Brain Injury

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Anatomical Context for Moderate and Severe Traumatic Brain Injury

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34MalaCards
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MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

34
Brain

Animal Models for Moderate and Severe Traumatic Brain Injury or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Moderate and Severe Traumatic Brain Injury:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1ACE, APOE
2MP:00053759.0ACE, APOE
3MP:00053708.8ACE, APOE

Publications for Moderate and Severe Traumatic Brain Injury

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53PubMed
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Articles related to Moderate and Severe Traumatic Brain Injury:

idTitleAuthorsYear
1
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. (24139087)
2014
2
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. (24378157)
2013
3
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. (22511138)
2012
4
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. (16614010)
2006
5
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. (16525069)
2006

Variations for Moderate and Severe Traumatic Brain Injury

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Expression for genes affiliated with Moderate and Severe Traumatic Brain Injury

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Pathways for genes affiliated with Moderate and Severe Traumatic Brain Injury

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51PathCards, 55R&D Systems
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Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ACE, APOE

Compounds for genes affiliated with Moderate and Severe Traumatic Brain Injury

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1sele469.4ACE, APOE
2atenolol46 52 30 25 1213.4ACE, APOE
3warfarin46 52 25 1212.4ACE, APOE
4fluvastatin46 52 30 1212.3APOE, ACE
5losartan46 52 30 1212.3ACE, APOE
6pravastatin46 52 30 25 1213.3ACE, APOE
7atorvastatin46 52 30 25 1213.2APOE, ACE
8prostacyclin469.2ACE, APOE
9aspirin46 52 30 2512.1ACE, APOE
10cholesterol46 30 25 1212.1ACE, APOE
11acetylcholine46 52 30 25 1213.0APOE, ACE
12creatinine468.8ACE, APOE

GO Terms for genes affiliated with Moderate and Severe Traumatic Brain Injury

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17Gene Ontology
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Cellular components related to Moderate and Severe Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1ACE, APOE

Products for genes affiliated with Moderate and Severe Traumatic Brain Injury

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  • Antibodies
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Sources for Moderate and Severe Traumatic Brain Injury

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet