MCID: MDR006
MIFTS: 23

Moderate and Severe Traumatic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Moderate and Severe Traumatic Brain Injury

Summaries for Moderate and Severe Traumatic Brain Injury

MalaCards based summary : Moderate and Severe Traumatic Brain Injury is related to brain injury and traumatic brain injury. An important gene associated with Moderate and Severe Traumatic Brain Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drugs Mannitol and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Moderate and Severe Traumatic Brain Injury

Graphical network of the top 20 diseases related to Moderate and Severe Traumatic Brain Injury:



Diseases related to Moderate and Severe Traumatic Brain Injury

Symptoms & Phenotypes for Moderate and Severe Traumatic Brain Injury

Drugs & Therapeutics for Moderate and Severe Traumatic Brain Injury

Drugs for Moderate and Severe Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4 Central Nervous System Depressants Phase 4,Phase 2
5 Adjuvants, Anesthesia Phase 4
6 GABA Agents Phase 4
7 GABA Modulators Phase 4
8 Neurotransmitter Agents Phase 4
9 Tranquilizing Agents Phase 4
10 Hemostatics Phase 4,Phase 3
11 Anesthetics Phase 4,Phase 2
12 Anesthetics, General Phase 4
13 Anesthetics, Intravenous Phase 4
14 Anti-Anxiety Agents Phase 4
15 Hypnotics and Sedatives Phase 4
16 Psychotropic Drugs Phase 4
17
Tranexamic Acid Approved Phase 3 1197-18-8 5526
18
Choline Approved, Nutraceutical Phase 3 62-49-7 305
19 Pharmaceutical Solutions Phase 3,Phase 2
20 Coagulants Phase 3
21 Antifibrinolytic Agents Phase 3
22 Cytidine Diphosphate Choline Phase 3
23 Nootropic Agents Phase 3
24 Ether Phase 2
25 Pregnanolone Phase 2 128-20-1
26
Testosterone Approved, Investigational 58-22-0 6013
27
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
28 Hormones
29 glucagon
30 Estradiol valerate 979-32-8
31 beta-endorphin
32 Follicle Stimulating Hormone
33 Adrenocorticotropic Hormone
34 Glucagon-Like Peptide 1
35 Estradiol 17 beta-cypionate
36 Estradiol 3-benzoate
37 Polyestradiol phosphate
38 Melanocyte-Stimulating Hormones

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
2 Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury Recruiting NCT02794168 Phase 3 VAS203;Saline
3 Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury Not yet recruiting NCT02645552 Phase 3 Tranexamic Acid
4 Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT) Terminated NCT00545662 Phase 3 Placebo;citicoline
5 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
6 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed NCT01673828 Phase 2 Allopregnanolone injection;Placebo injection
7 A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury. Terminated NCT00735085 Phase 2 SLV334;SLV334;SLV334;SLV334;Placebo
8 Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury Unknown status NCT01512524
9 Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury Completed NCT01955785
10 Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury Recruiting NCT03169647
11 The PIT-TBI Pilot Study Active, not recruiting NCT02480985

Search NIH Clinical Center for Moderate and Severe Traumatic Brain Injury

Genetic Tests for Moderate and Severe Traumatic Brain Injury

Anatomical Context for Moderate and Severe Traumatic Brain Injury

MalaCards organs/tissues related to Moderate and Severe Traumatic Brain Injury:

38
Brain

Publications for Moderate and Severe Traumatic Brain Injury

Articles related to Moderate and Severe Traumatic Brain Injury:

# Title Authors Year
1
Characteristics of Moderate and Severe Traumatic Brain Injury of Motorcycle Crashes in Bandung, Indonesia. ( 28087431 )
2017
2
Management of Spasticity in Moderate and Severe Traumatic Brain Injury: Evaluation of Clinical Practice Guidelines. ( 27120291 )
2016
3
Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury. ( 24139087 )
2014
4
Impact of rehabilitation on functional outcome during the first year of moderate and severe traumatic brain injury. ( 24378157 )
2013
5
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. ( 22511138 )
2012
6
Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. ( 16614010 )
2006
7
Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. ( 16525069 )
2006

Variations for Moderate and Severe Traumatic Brain Injury

Expression for Moderate and Severe Traumatic Brain Injury

Search GEO for disease gene expression data for Moderate and Severe Traumatic Brain Injury.

Pathways for Moderate and Severe Traumatic Brain Injury

Pathways related to Moderate and Severe Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 ACE APOE

GO Terms for Moderate and Severe Traumatic Brain Injury

Sources for Moderate and Severe Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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