MCID: MDY006
MIFTS: 19

Mody, Type Iv malady

Genetic diseases, Rare diseases categories

Summaries for Mody, Type Iv

About this section


MalaCards based summary: Mody, Type Iv, also known as type 4 maturity-onset diabetes of the young, is related to pancreatitis, and has symptoms including autosomal dominant inheritanceand type ii diabetes mellitus. An important gene associated with Mody, Type Iv is PDX1 (pancreatic and duodenal homeobox 1).

Description from OMIM:45 606392

Aliases & Classifications for Mody, Type Iv

About this section

Mody, Type Iv, Aliases & Descriptions:

Name: Mody, Type Iv 45 10
Type 4 Maturity-Onset Diabetes of the Young 41 20 22
Maturity-Onset Diabetes of the Young, Type 4 45 41
Maturity-Onset Diabetes of the Young, Type Iv 60
 
Mody Insulin Promoter Factor-1 Related 41
Diabetes Mellitus Mody Type 4 41
Mody Type 4 41
Mody4 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


External Ids:

OMIM45 606392

Related Diseases for Mody, Type Iv

About this section

Diseases related to Mody, Type Iv via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis10.1

Symptoms for Mody, Type Iv

About this section


Clinical features from OMIM:

606392

HPO human phenotypes related to Mody, Type Iv:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 type ii diabetes mellitus HP:0005978

Drugs & Therapeutics for Mody, Type Iv

About this section

Drug clinical trials:

Search ClinicalTrials for Mody, Type Iv

Search NIH Clinical Center for Mody, Type Iv

Genetic Tests for Mody, Type Iv

About this section

Genetic tests related to Mody, Type Iv:

id Genetic test Affiliating Genes
1 Maturity-Onset Diabetes of the Young Type 420 PDX1
2 Maturity-Onset Diabetes of the Young, Type 422

Anatomical Context for Mody, Type Iv

About this section

Animal Models for Mody, Type Iv or affiliated genes

About this section

Publications for Mody, Type Iv

About this section

Variations for Mody, Type Iv

About this section

UniProtKB/Swiss-Prot genetic disease variations for Mody, Type Iv:

62
id Symbol AA change Variation ID SNP ID
1PDX1p.Cys18ArgVAR_009309
2PDX1p.Gln59LeuVAR_009310
3PDX1p.Arg197HisVAR_009312

Clinvar genetic disease variations for Mody, Type Iv:

6
id Gene Variation Type Significance SNP ID Assembly Location
1PDX1NM_000209.3(PDX1): c.442C> G (p.Arg148Gly)single nucleotide variantLikely pathogenicrs193922355GRCh37Chr 13, 28498428: 28498428
2PDX1NM_000209.3(PDX1): c.571A> C (p.Lys191Gln)single nucleotide variantLikely pathogenicrs193922356GRCh37Chr 13, 28498557: 28498557
3PDX1NM_000209.3(PDX1): c.725C> T (p.Pro242Leu)single nucleotide variantLikely pathogenicrs193922358GRCh37Chr 13, 28498711: 28498711
4PDX1NM_000209.3(PDX1): c.773A> G (p.Glu258Gly)single nucleotide variantLikely pathogenicrs193922360GRCh37Chr 13, 28498759: 28498759
5PDX1PDX1, 1-BP DEL, 188CdeletionPathogenic
6PDX1NM_000209.3(PDX1): c.226G> A (p.Asp76Asn)single nucleotide variantrisk factorrs137852783GRCh37Chr 13, 28494501: 28494501

Expression for genes affiliated with Mody, Type Iv

About this section
Search GEO for disease gene expression data for Mody, Type Iv.

Pathways for genes affiliated with Mody, Type Iv

About this section

Compounds for genes affiliated with Mody, Type Iv

About this section

GO Terms for genes affiliated with Mody, Type Iv

About this section

Products for genes affiliated with Mody, Type Iv

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Mody, Type Iv

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet