MCID: MLL001
MIFTS: 54

Molluscum Contagiosum malady

Infectious diseases category

Summaries for Molluscum Contagiosum

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards: Molluscum Contagiosum is related to dermatitis and atopic dermatitis, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is LOR (loricrin), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The drug cantharidin and the compounds imidazoquinoline and collodion have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Wikipedia:63 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Aliases & Classifications for Molluscum Contagiosum

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Molluscum Contagiosum

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17GeneCards, 18GeneDecks
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Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.8LOR, CCL27, TLR9, FLG, IVL, IL18
2atopic dermatitis30.7FLG, CCL27, LOR
3herpes simplex30.7TLR9, TLR3, TLR7
4psoriasis30.5LOR, CCL27, TLR9, IFN1@, FLG, IVL
5sarcoma30.4TOP1, FADD
6papilloma30.4KRT14, IVL, FLG, LOR
7squamous cell carcinoma30.4CASP8, FADD, FLG, TOP1, IVL, KRT16
8keratoacanthoma30.2IVL
9myeloma30.2CASP8
10lichen planus30.2KRT16, IVL, FLG
11arthritis30.2TLR3, FLG, IL18
12lupus erythematosus30.2IL18, TLR7, TLR9
13hepatitis30.2CCL27, CASP8, TLR3, IL18
14asthma30.2CASP8, TLR9, TLR3, FLG, IL18, CCR8
15hepatitis b30.2CCL27, CASP8, TLR3, IFN1@, FADD, TOP1
16leukemia30.2CASP8, IFN1@, FADD, TOP1, IVL, IL11RA
17melanoma30.2CASP8, TLR9, TLR3, TLR7, TOP1, IL18BP
18rheumatoid arthritis30.2CCL27, CASP8, TLR9, TLR3, FADD, FLG
19leprosy10.6
20acquired immunodeficiency syndrome10.5
21cryptococcosis10.5
22lepromatous leprosy10.5
23basal cell carcinoma10.4
24burns10.3
25erythema multiforme10.3
26vaccinia10.3
27folliculitis10.3
28cellulitis10.3
29herpes zoster10.3
30hodgkin's lymphoma10.3
31scabies10.3
32indeterminate leprosy10.2
33cutaneous lupus erythematosus10.2
34tinea barbae10.2
35acantholytic acanthoma10.2
36job's syndrome10.2
37common wart10.2
38wiskott-aldrich syndrome10.2
39methemoglobinemia10.2
40nodular basal cell carcinoma10.2
41lichen nitidus10.2
42focal epithelial hyperplasia10.2
43kaposi's sarcoma10.2
44ecthyma10.2
45mycosis fungoides10.2
46adult lymphoma10.2
47toxic shock syndrome10.2
48vitiligo10.2
49granuloma annulare10.2
50plantar wart10.2

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Clinical Features for Molluscum Contagiosum

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8Disease Ontology
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Symptoms:

8
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Molluscum Contagiosum

Drug clinical trials:

Search ClinicalTrials for Molluscum Contagiosum

Search NIH Clinical Center for Molluscum Contagiosum

Search CenterWatch for Molluscum Contagiosum

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Molluscum Contagiosum

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Anatomical Context for Molluscum Contagiosum

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Molluscum Contagiosum:

32
Skin, T cells, Cervix, Myeloid, Bone marrow, Lung, Bone, B cells

FMA organs/tissues related to Molluscum Contagiosum:

14
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Molluscum Contagiosum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2TLR9, TLR7, FADD, FLG, ATG3, IL11RA
2MP:00053768.6LOR, CASP8, TLR9, TLR3, TLR7, FADD
3MP:00053878.6KRT14, LOR, CCR8, CASP8, TLR9, TLR3
4MP:00107688.6FADD, TLR7, TLR3, TLR9, CASP8, FLG
5MP:00053848.6FADD, TLR7, TLR9, CASP8, FLG, ATG3

Publications for Molluscum Contagiosum

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50PubMed
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Articles related to Molluscum Contagiosum:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Giant molluscum contagiosum - a clue to the diagnosis of human immunodeficiency virus infection. (24206800)
2013
2
Dermoscopy of giant molluscum contagiosum. (24238183)
2013
3
Atypical molluscum contagiosum accompanied by CD30-positive lymphoid infiltrates. (22067049)
2013
4
Intraoral molluscum contagiosum in a young immunocompetent patient. (22727108)
2012
5
A mistaken diagnosis of Molluscum contagiosum in a HIV-positive patient in rural South Africa. (23242094)
2012
6
The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-I_B activation by interacting with the II_B kinase complex. (22301546)
2012
7
Disseminated molluscum contagiosum infection in a hyper IgE syndrome. (22565443)
2012
8
Ulcerating molluscum contagiosum in a boy with relapsed acute lymphoblastic leukemia. (21368674)
2011
9
An immunocompromised woman with severe molluscum contagiosum that responded well to topical imiquimod: a case report and literature review. (20354423)
2010
10
Molluscum contagiosum virus infection in benign cutaneous epithelial cystic lesions-report of 2 cases with different pathogenesis? (20700040)
2010
11
Solitary giant molluscum contagiosum presenting as lid tumor in an immunocompetent child. (20413930)
2010
12
Molluscum contagiosum detection rates among Greek dermatology outpatients. (20500118)
2010
13
Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site. (21886755)
2010
14
Vertically transmitted molluscum contagiosum infection. (20064865)
2010
15
Disfiguring molluscum contagiosum in a HIV-positive patient responding to antiretroviral therapy. (20101316)
2009
16
Molluscum contagiosum of the sole. (18429987)
2009
17
Cidofovir diphosphate inhibits molluscum contagiosum virus DNA polymerase activity. (18007584)
2008
18
Curettage treatment for molluscum contagiosum: a follow-up survey study. (18795919)
2008
19
Case of AIDS disclosed by refractory pruritic xerosis and molluscum contagiosum. (17727374)
2007
20
Erythema multiforme associated with resolving molluscum contagiosum. (17137481)
2007
21
Case detection rates of molluscum contagiosum in childhood. (17461827)
2007
22
Childhood molluscum contagiosum. (16445494)
2006
23
The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation. (16378960)
2006
24
Epidemiology and impact of childhood molluscum contagiosum: a case series and critical review of the literature. (16060861)
2005
25
Treatment of molluscum contagiosum with 585 nm collagen remodeling pulsed dye laser. (15197000)
2004
26
Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review. (15221307)
2004
27
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
28
Clinical profile of molluscum contagiosum in children versus adults. (14996374)
2003
29
Treatment of molluscum contagiosum with the pulsed dye laser over a 28-month period. (12769411)
2003
30
Molecular epidemiology of molluscum contagiosum virus and analysis of the host-serum antibody response in Spanish HIV-negative patients. (11782922)
2002
31
Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. (11210936)
2001
32
Molluscum contagiosum and Job's syndrome. (11832646)
2001
33
Scarring molluscum contagiosum in patients with severe atopic dermatitis: report of two cases. (11359410)
2001
34
MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-kappaB activation and apoptosis induced by PKR. (11714980)
2001
35
Topical cidofovir for severe cutaneous human papillomavirus and molluscum contagiosum infections in patients with HIV/AIDS. A pilot study. (11444271)
2000
36
Mapping of mRNA transcripts in the genome of molluscum contagiosum virus: transcriptional analysis of the viral slam gene family. (11129634)
2000
37
Molluscum contagiosum appearing as a solitary lesion on the eyelid. (10692832)
2000
38
The surgical treatment of Molluscum contagiosum in a pediatric AIDS patient. (10884085)
2000
39
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. (11069514)
2000
40
Topical imiquimod therapy for chronic giant molluscum contagiosum in a patient with advanced human immunodeficiency virus 1 disease. (10522662)
1999
41
Topical cidofovir for severe molluscum contagiosum. (10376628)
1999
42
Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. (10556532)
1999
43
Cutaneous cryptococcosis resembling molluscum contagiosum in a patient with non-Hodgkin's lymphoma. (10530468)
1999
44
Immunoreactive proteins of molluscum contagiosum virus types 1, 1v, and 2. (9806070)
1998
45
Molluscum contagiosum virus. (9120320)
1997
46
Treatment of molluscum contagiosum with oral cimetidine: clinical experience in 13 patients. (8844752)
1996
47
Replication of molluscum contagiosum virus. (7491789)
1995
48
Molluscum contagiosum and human immunodeficiency virus. (1417038)
1992
49
Molluscum contagiosum in human immunodeficiency virus infection: response to zidovudine. (2753594)
1989
50
Clearing of subacute cutaneous lupus erythematosus around molluscum contagiosum lesions. (7076906)
1982

Genetic Variations for Molluscum Contagiosum

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Expression for genes affiliated with Molluscum Contagiosum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2FADD, CASP8
2
Hide members
10.2FADD, CASP8
3
Apoptosis and survival Caspase cascade
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10.0CASP8, FADD, TOP1
4
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10.0FADD, TLR3, CASP8
5
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10.0TLR9, TLR3, TLR7
610.0TLR7, TLR3, TLR9
710.0TLR7, TLR3, TLR9
810.0TLR9, TLR3, TLR7
99.9IL18, FADD, TLR9, CASP8
10
Hide members
9.8IL18, TLR7, TLR3, TLR9
11
Hide members
9.8TLR9, TLR3, TLR7, IL18
129.8CASP8, TLR9, TLR3, TLR7
13
Hide members
9.8TLR9, TLR3, TLR7, FADD
14
Hide members
9.8TLR9, TLR3, TLR7, FADD
15
Hide members
9.7CCR8, CASP8, FADD, IL11RA, IL18
16
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9.7CASP8, TLR9, TLR3, TLR7, FADD
17
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
18
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
19
Hide members
9.6IL18, IL11RA, CASP8, CCL27, CCR8
20
Hide members
9.5CASP8, TLR9, TLR3, TLR7, FADD, IL18
21
Hide members
9.5CCR8, CCL27, CASP8, ANAPC11, IL11RA
22
Hide members
9.3CASP8, TLR9, TLR3, TLR7, FADD, ANAPC11
23
Hide members
9.1IL18, CCR8, CCL27, TLR9, TLR3, TLR7

Compounds for genes affiliated with Molluscum Contagiosum

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB
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Compounds related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1imidazoquinoline4410.6TLR7, IL18
2collodion4410.5IVL, LOR
3pam2csk45910.5TLR3, TLR7
4pam3csk45910.5TLR3, TLR7
5poly(i:c)5910.5TLR3, TLR7
6loxoribine44 2811.5TLR9, TLR7
74,6-diamidino-2-phenylindole4410.4TOP1, CASP8
8epsilon-(gamma-glutamyl)lysine4410.4LOR, IVL
9dithranol4410.4FLG, IVL, KRT16
10flagellin44 2811.4IL18, TLR3, TLR9
11arsenate4410.4IVL, FLG
12ursolic acid4410.4TOP1, CASP8
13imiquimod44 28 59 1113.4IL18, TLR7, TLR3
14hematoxylin4410.4LOR, IVL, KRT14
15resiquimod44 5911.4TLR9, TLR3, TLR7
16vitamin a44 11 2412.4LOR, KRT16, KRT14
17ifn-alpha4410.3IL18, TLR3, CASP8
18mitomycin c4410.3CASP8, FADD, TOP1, IL18
19peptidoglycan44 2811.3TLR7, TLR3, TLR9
20lipoteichoic acid4410.3TLR9, TLR3, TLR7, IL18
21hydroxychloroquine44 1111.3TLR9, TLR7
22polyinosinic-polycytidylic acid4410.3TLR9, TLR3, TLR7, IL18
23calcipotriol44 59 28 1113.3KRT14, KRT16, IVL, FLG
24tarc4410.3CCR8, CCL27, IL18
25poly(i-c)4410.3IL18, TLR7, TLR3, TLR9
26ceramide4410.2CASP8, FADD, FLG, IVL
27chloroquine44 2 49 28 1114.2TLR9, TLR7, IL18
28allergens4410.2IL18, IVL, FLG, CCL27
29endotoxin4410.2TLR9, TLR3, IL18, IL18BP
30ccl344 2811.2CCR8, CCL27, TLR9, IL18
31sp 60012544 5911.2IL18, FADD, CASP8
325fluorouracil4410.1CASP8, FADD, TOP1, IVL, IL18
33retinoid4410.1CASP8, FLG, IVL, KRT16, KRT14
34sodium dodecylsulfate4410.1IVL, IL18, KRT16
35cisplatin44 49 59 1113.0CASP8, FADD, TOP1, IL18, KRT14
361,25 dihydroxy vitamin d34410.0KRT16, IL18, IVL
37doxorubicin44 49 1111.9IL18, TOP1, FADD, CASP8
38shikonin449.9TOP1, CASP8
39cholesterol44 28 11 2412.9LOR, CCL27, FADD, IVL, IL18, KRT14
40serine449.9LOR, TLR3, FLG, IVL, IL18, KRT16
41cysteine449.7CASP8, FADD, FLG, IVL, IL18, KRT14
42retinoic acid44 2410.7LOR, CASP8, TLR3, FLG, IVL, IL18
43steroid449.6LOR, FLG, IVL, IL18, KRT16
44lipid449.6LOR, CCL27, FADD, FLG, IVL, IL18
45tyrosine449.5CASP8, TLR9, TLR3, FADD, FLG, IVL

GO Terms for genes affiliated with Molluscum Contagiosum

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16Gene Ontology
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Cellular components related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:03200910.1TLR9, TLR7
2CD95 death-inducing signaling complexGO:03126510.1CASP8, FADD
3endolysosome membraneGO:03602010.0TLR7, TLR3, TLR9
4intermediate filamentGO:00588210.0KRT14, KRT16, FLG
5death-inducing signaling complexGO:0312649.9FADD, CASP8

Biological processes related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:03412310.4TLR9, TLR3
2activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
3positive regulation of interferon-alpha biosynthetic processGO:04535610.3TLR9, TLR3, TLR7
4positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR9, TLR3, TLR7
5I-kappaB phosphorylationGO:00725210.3TLR7, TLR3, TLR9
6positive regulation of interferon-gamma biosynthetic processGO:04507810.2TLR9, TLR3, TLR7
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.2CASP8, FADD
8keratinocyte differentiationGO:03021610.2IVL, FLG, LOR
9positive regulation of interleukin-6 productionGO:03275510.2TLR7, TLR3, TLR9
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.2FADD, TLR3, CASP8
11positive regulation of chemokine productionGO:03272210.2TLR9, TLR3, TLR7, IL18
12positive regulation of tumor necrosis factor productionGO:03276010.2IL18, FADD, TLR3, TLR9
13positive regulation of NF-kappaB import into nucleusGO:04234610.2IL18, TLR7, TLR3, TLR9
14MyD88-independent toll-like receptor signaling pathwayGO:00275610.2CASP8, TLR3, FADD
15positive regulation of inflammatory responseGO:05072910.1IL18, TLR7, TLR3, TLR9
16toll-like receptor 3 signaling pathwayGO:03413810.1FADD, TLR3, CASP8
17positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1FADD, TLR3, TLR9, CASP8
18cellular response to mechanical stimulusGO:07126010.1CASP8, TLR3, TLR7, FADD, IL18
19T-helper 1 type immune responseGO:04208810.1IL18, IL18BP
20positive regulation of interleukin-8 productionGO:03275710.0IL18, FADD, TLR7, TLR3, TLR9
21toll-like receptor 4 signaling pathwayGO:03414210.0FADD, TLR3, CASP8
22toll-like receptor signaling pathwayGO:00222410.0CASP8, TLR9, TLR3, TLR7, FADD
23innate immune responseGO:0450879.7TLR9, TLR3, TLR7, FADD, CASP8
24inflammatory responseGO:0069549.5IL18, TLR7, TLR3, TLR9

Molecular functions related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1siRNA bindingGO:03519710.0TLR7, TLR9
2transmembrane signaling receptor activityGO:00488810.0IL11RA, TLR3, TLR9
3structural constituent of cytoskeletonGO:0052009.7KRT14, KRT16, LOR

Products for genes affiliated with Molluscum Contagiosum

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Molluscum Contagiosum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet