MCID: MLL001
MIFTS: 51

Molluscum Contagiosum malady

Infectious diseases, Skin diseases categories

Summaries for Molluscum Contagiosum

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards: Molluscum Contagiosum is related to atopic dermatitis and dermatitis, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is LOR (loricrin), and among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Legionellosis. The drug cantharidin and the compounds hematoxylin and infliximab have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are integument and hematopoietic system.

Wikipedia:66 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Aliases & Classifications for Molluscum Contagiosum

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 26ICD10
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Related Diseases for Molluscum Contagiosum

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Symptoms for Molluscum Contagiosum

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9Disease Ontology
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Symptoms:

9
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Molluscum Contagiosum

Drug clinical trials:

Search ClinicalTrials for Molluscum Contagiosum

Search NIH Clinical Center for Molluscum Contagiosum

Search CenterWatch for Molluscum Contagiosum

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Molluscum Contagiosum

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Anatomical Context for Molluscum Contagiosum

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Molluscum Contagiosum:

34
Skin, T cells, Cervix, Myeloid, Bone marrow, Lung, Bone, B cells

FMA organs/tissues related to Molluscum Contagiosum:

15
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Molluscum Contagiosum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4LOR, CASP8, IL18, FLG
2MP:00053978.4CASP8, IL11RA, IL18, FLG
3MP:00053878.0CASP8, FLG, LOR, IL18, IL11RA
4MP:00053787.9FLG, LOR, IL11RA, CASP8, IL18
5MP:00107687.2CASP8, FLG, TOP1, IL18, IL11RA

Publications for Molluscum Contagiosum

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53PubMed
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Articles related to Molluscum Contagiosum:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Idiopathic CD4 lymphocytopenia presenting as recurrent giant molluscum contagiosum. (23760345)
2013
2
Unusual manifestation of molluscum contagiosum: eruptive papules on the face and neck of an immunocompetent patient. (24003298)
2013
3
Gross generalized molluscum contagiosum in a patient with autosomal recessive hyper-IgE syndrome, which resolved spontaneously after haematopoietic stem-cell transplantation. (23020750)
2013
4
An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. (22214282)
2013
5
Follicular Induction in a Case of Molluscum Contagiosum: Possible Link With Secondary Anetoderma-Like Changes? (23676321)
2013
6
Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001. (22262788)
2012
7
Molluscum contagiosum as a skin manifestation of immune reconstitution inflammatory syndrome in an AIDS patient who is receiving HAART. (22787541)
2012
8
What is your diagnosis? Inflamed molluscum contagiosum as a manifestation of immune reconstitution inflammatory syndrome. (22768431)
2012
9
Dermoscopic patterns of molluscum contagiosum: a study of 211 lesions confirmed by histopathology. (21437525)
2011
10
What is your diagnosis? Molluscum contagiosum on the sole of the foot. (21644487)
2011
11
Molluscum contagiosum in an epidermoid cyst. (21712689)
2011
12
Recalcitrant giant molluscum contagiosum in a patient with advanced HIV disease - eradication of disease with paclitaxel. (21245518)
2010
13
An immunocompromised woman with severe molluscum contagiosum that responded well to topical imiquimod: a case report and literature review. (20354423)
2010
14
Molluscum contagiosum: A 20-year study in a sexually transmitted infections unit. (20414149)
2010
15
Treatment of facial molluscum contagiosum with trichloroacetic acid. (19689517)
2009
16
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
17
Resolution of giant Molluscum contagiosum with antiretroviral therapy. (18583804)
2008
18
Medical Pearl: confirming the diagnosis of molluscum contagiosum using 10% potassium hydroxide. (17434028)
2007
19
Detection of Molluscum contagiosum virus (MCV) subtype I as a single dominant virus subtype in Molluscum lesions from a Turkish population. (16513490)
2006
20
Topical treatment of molluscum contagiosum with imiquimod 5% cream in Turkish children. (16911087)
2006
21
Molluscum contagiosum infection during the treatment of vitiligo with tacrolimus ointment. (15761441)
2005
22
Treatment of molluscum contagiosum with 585 nm collagen remodeling pulsed dye laser. (15197000)
2004
23
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
24
Photodynamic therapy for molluscum contagiosum infection in HIV-coinfected patients: review of 6 patients. (14711142)
2003
25
Molluscum contagiosum. (12639455)
2003
26
Clinical profile of molluscum contagiosum in children versus adults. (14996374)
2003
27
Molluscum contagiosum: recent advances in pathogenic mechanisms, and new therapies. (12358555)
2002
28
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. (11493620)
2001
29
Efficacy of emlap cream in children having molluscum contagiosum. (17664726)
2001
30
Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. (11210936)
2001
31
Treatment of molluscum contagiosum with topical 5% imiquimod cream. (11085678)
2000
32
Pleomorphic T-cell infiltrate associated with molluscum contagiosum. (10218681)
1999
33
Characterization of early gene transcripts of molluscum contagiosum virus. (10208926)
1999
34
DNA contacts by protein domains of the molluscum contagiosum virus type-1B topoisomerase. (10502526)
1999
35
Molluscum contagiosum. (9891691)
1998
36
Recalcitrant molluscum contagiosum in a patient with AIDS successfully treated by a combination of CO2-laser and natural interferon beta gel. (9689311)
1998
37
Molluscum contagiosum eyelid lesions as the initial manifestation of acquired immunodeficiency syndrome. (9262550)
1997
38
Failure to detect human papilloma virus in cutaneous molluscum contagiosum lesions. (9494606)
1997
39
HIV-positive patient presented with giant molluscum contagiosum of the eyelid. (9420414)
1997
40
Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. (8938977)
1996
41
Expression of keratohyalin-trichohyalin hybrid granules in molluscum contagiosum. (8850037)
1996
42
Replication of molluscum contagiosum virus. (7491789)
1995
43
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus. (7618282)
1995
44
Molluscum contagiosum. (7928025)
1994
45
Facial and perioral molluscum contagiosum in patients with HIV infection. A report of eight cases. (7838470)
1994
46
Cutaneous cryptococcosis resembling molluscum contagiosum in a homosexual man with AIDS. Report of a case and review of the literature. (1357854)
1992
47
Molluscum contagiosum in HIV-infected patients. (1558989)
1992
48
Giant molluscum contagiosum following splenectomy. (2383191)
1990
49
Treatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia. (2229496)
1990
50
What is molluscum contagiosum? (2602309)
1989

Variations for Molluscum Contagiosum

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Expression for genes affiliated with Molluscum Contagiosum

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN
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Compounds for genes affiliated with Molluscum Contagiosum

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1hematoxylin4610.0LOR, FLG
2infliximab46 52 1211.9FLG, IL18
3allergens469.8IL18, FLG
4latex469.8IL18, FLG
5mevalonate469.7IL18, CASP8
6ifn-alpha469.7CASP8, IL18
7pdtc469.6IL18, CASP8
8tetracycline46 1210.6IL18, CASP8
9sp 60012546 6210.6IL18, CASP8
10ciprofloxacin46 52 1211.5TOP1, IL18
114,6-diamidino-2-phenylindole469.5TOP1, CASP8
12ursolic acid469.5CASP8, TOP1
13shikonin469.5TOP1, CASP8
14betulinic acid46 3010.4CASP8, TOP1
15tgf beta1469.4IL18, CASP8
16topotecan46 1210.4CASP8, TOP1
17depsipeptide469.4TOP1, CASP8
18oxaliplatin46 52 1211.4CASP8, TOP1
19simvastatin46 52 62 30 25 1214.4CASP8, IL18
20flavopiridol46 1210.4CASP8, TOP1
21melphalan46 52 1211.4TOP1, CASP8
22steroid469.4FLG, IL18, LOR
23daunorubicin46 52 1211.4TOP1, CASP8
24bortezomib46 52 1211.4CASP8, TOP1
25adpribose469.3CASP8, TOP1
26gemcitabine46 52 1211.3TOP1, CASP8
27curcumin469.2CASP8, IL18
28adriamycin469.2CASP8, TOP1
29camptothecin46 62 1211.2CASP8, TOP1
30docetaxel46 52 62 1212.2CASP8, TOP1
31cyclophosphamide46 52 1211.1IL18, TOP1
32arginine469.1IL18, FLG, CASP8
33mitomycin c468.9TOP1, CASP8, IL18
34egcg468.9TOP1, IL18, CASP8
355fluorouracil468.9CASP8, TOP1, IL18
36doxorubicin46 52 1210.9CASP8, IL18, TOP1
37cisplatin46 52 62 1211.9TOP1, IL18, CASP8
38retinoic acid46 259.9CASP8, FLG, LOR, IL18
39cysteine468.9IL18, FLG, CASP8
40cycloheximide468.9CASP8, TOP1, IL18
41serine468.9IL18, LOR, CASP8, FLG
42h2o2468.8TOP1, IL18, CASP8
435-aza-2deoxycytidine468.7CASP8, TOP1

GO Terms for genes affiliated with Molluscum Contagiosum

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17Gene Ontology
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Biological processes related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratinocyte differentiationGO:0302169.6LOR, FLG
2natural killer cell activationGO:0301019.2CASP8, IL18
3cellular response to organic cyclic compoundGO:0714079.0CASP8, IL18

Products for genes affiliated with Molluscum Contagiosum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Molluscum Contagiosum

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet