MCID: MLL001
MIFTS: 42

Molluscum Contagiosum malady

Categories: Infectious diseases

Aliases & Classifications for Molluscum Contagiosum

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.

MalaCards based summary : Molluscum Contagiosum is related to hyper-ige recurrent infection syndrome, autosomal recessive and leprosy, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Toll-Like receptor Signaling Pathways. The drugs Pharmaceutical Solutions and Cantharidin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and cervix.

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 71 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin and... more...

Related Diseases for Molluscum Contagiosum

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2, Phase 3
2 Cantharidin Phase 2 56-25-7
3 Dermatologic Agents Phase 2
4
Benzocaine Approved 1994-09-7, 94-09-7 2337
5 tannic acid Approved, Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3
2 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2
3 A Study of VBP-245 in Pediatric Patients With Molluscum Contagiosum Recruiting NCT03077750 Phase 2
4 A Dose Range-Finding Phase 2 Trial of a Botanical Drug for the Treatment of Molluscum Contagiosum in Pediatric Subjects Recruiting NCT02024581 Phase 2
5 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Recruiting NCT02902822 Phase 2
6 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Enrolling by invitation NCT03017846 Phase 2
7 Efficacy of Cantharidin in Molluscum Contagiosum Completed NCT00667225

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

MalaCards organs/tissues related to Molluscum Contagiosum:

39
Skin, T Cells, Cervix, Lung, Bone, Myeloid, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

18
Skin

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 588)
id Title Authors Year
1
Molluscum Contagiosum: A Rare Nipple Lesion. ( 27670745 )
2017
2
Desmoplastic trichilemmoma dermoscopically mimicking molluscum contagiosum. ( 28087019 )
2017
3
Corpora amylacea and molluscum contagiosum on a cervical pap smear. ( 27863182 )
2017
4
Bulbar Conjunctival Molluscum Contagiosum. ( 26802706 )
2016
5
Cytodiagnosis of disseminated histoplasmosis in an immunocompetent individual with molluscum contagiosum-like skin lesions and lymphadenopathy. ( 27756991 )
2016
6
Interventions for molluscum contagiosum in people infected with human immunodeficiency virus: a systematic review. ( 26991246 )
2016
7
Extensive molluscum contagiosum virus infection in a young adult receiving fingolimod. ( 26860987 )
2016
8
Isolated giant molluscum contagiosum mimicking epidermoid cyst. ( 27648389 )
2016
9
Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. ( 26900921 )
2016
10
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( 27397059 )
2016
11
Recalcitrant molluscum contagiosum successfully treated with sinecatechins. ( 26809498 )
2016
12
Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum. ( 27041686 )
2016
13
Pubic hair removal and molluscum contagiosum. ( 27278448 )
2016
14
Widespread Molluscum Contagiosum with Atopic Dermatitis-like Skin Manifestations. ( 27534943 )
2016
15
Clinical and Demographic Characteristics of Patients with Molluscum Contagiosum Treated at the University Dermatology Clinic Maribor in a 5-year period. ( 27477173 )
2016
16
Treatment of Molluscum Contagiosum with Imiquimod in the United States: A Retrospective Cross-Sectional Study. ( 26608213 )
2016
17
Molluscum Contagiosum Over Tattooed Skin. ( 27226923 )
2016
18
Molluscum contagiosum of the eyelid: case report in a man receiving methotrexate and literature review of molluscum contagiosum in patients who are immunosuppressed secondary to methotrexate or HIV infection. ( 27136625 )
2016
19
Giant Eyelid Molluscum Contagiosum in a Child with AIDS. ( 27549877 )
2016
20
Case of disseminated molluscum contagiosum caused by ruxolitinib, a Janus kinase 1 and 2 inhibitor. ( 27060215 )
2016
21
To Treat Molluscum Contagiosum or Not-Curettage: An Effective, Well-Accepted Treatment Modality. ( 27601304 )
2016
22
Giant molluscum contagiosum presenting as lid neoplasm in an immunocompetent child. ( 26990479 )
2016
23
Disseminated molluscum contagiosum following chemotherapy: A therapeutic challenge. ( 27852995 )
2016
24
Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care. ( 26639950 )
2016
25
Plantar Molluscum Contagiosum in an Adult Patient. ( 27269980 )
2016
26
Molluscum Contagiosum Infection Involving a Benign Epidermoid Cyst in an Immunocompetent Patient. ( 27319966 )
2016
27
Langerhans cell histiocytosis with molluscum contagiosum: A correlation? ( 28012207 )
2016
28
Handheld reflectance confocal microscopy for the diagnosis of molluscum contagiosum: Histopathology and dermoscopy correlation. ( 27282954 )
2016
29
Vascular network tightly enclosing lesions of molluscum contagiosum: Basket-like capillaries of molluscum. ( 27607603 )
2016
30
Woronoff Ring: A Novel Manifestation of Molluscum Contagiosum. ( 27871346 )
2016
31
Molluscum Contagiosum. ( 27627044 )
2016
32
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. ( 27896283 )
2016
33
Intralesional 5-fluorouracil: Novel therapy for extensive molluscum contagiosum in an immunocompetent adult. ( 27853002 )
2016
34
Extensive molluscum contagiosum causing obstruction of vision in HIV positive woman. ( 27294056 )
2016
35
Molluscum Contagiosum Viral Infection Treated With a Dilute Povidone-Iodine/Dimethylsulfoxide Preparation. ( 26690085 )
2016
36
Molluscum Contagiosum Virus Transcriptome in Abortively Infected Cultured Cells and a Human Skin Lesion. ( 26889040 )
2016
37
Dermatologists, imiquimod, and treatment of molluscum contagiosum in children: righting wrongs. ( 25587702 )
2015
38
Molluscum contagiosum in a 12-year-old child - report of a case and review of literature. ( 25709372 )
2015
39
Giant molluscum contagiosum with granulomatous inflammation and panniculitis: An unusual clinical and histopathological pattern in an HIV seropositive child. ( 26392667 )
2015
40
Unique Cyst in a 22-Year-Old Man. Molluscum contagiosum in an epidermoid cyst. ( 26588335 )
2015
41
Patient Perspectives: Molluscum Contagiosum. ( 26584708 )
2015
42
Molluscum Contagiosum-Induced Erythema Annulare Centrifugum. ( 26244443 )
2015
43
A comparative study of 10% KOH solution and 5% imiquimod cream for the treatment of Molluscum contagiosum in the pediatric age group. ( 25821725 )
2015
44
Primitive follicular induction in molluscum contagiosum. ( 26265178 )
2015
45
Atypical infantile genital Molluscum contagiosum. ( 26131875 )
2015
46
Giant Molluscum Contagiosum in an HIV positive patient. ( 26255893 )
2015
47
A case of Molluscum Contagiosum infection in a patient with Crohn's Disease, receiving combination therapy with azathioprine and adalimumab. ( 25908722 )
2015
48
The natural history of molluscum contagiosum in children. ( 25541477 )
2015
49
Histopathologic features of molluscum contagiosum other than molluscum bodies. ( 25891863 )
2015
50
Staphylococcus lugdunensis Abscesses Complicating Molluscum Contagiosum in Two Children. ( 25557353 )
2015

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 CASP8 FADD IFNB1 TLR2
2
Show member pathways
12.39 CASP8 FADD IFNB1 IL18BP TLR2
3
Show member pathways
12.31 CASP8 FADD IFNB1 TLR2
4
Show member pathways
12.09 CSTA FLG LOR
5
Show member pathways
11.91 CASP8 FADD TLR2
6 11.27 CASP8 FADD
7 11.27 CASP8 CORO1A FADD IFNB1 TLR2
8 11.22 CASP8 TLR2
9 11.08 CASP8 FADD
10 10.76 CASP8 FADD IFNB1
11 10.3 CASP8 FADD

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.54 CASP8 FADD TLR2
2 cell body GO:0044297 9.5 CASP8 FADD TLR2
3 death-inducing signaling complex GO:0031264 9.26 CASP8 FADD
4 ripoptosome GO:0097342 9.16 CASP8 FADD
5 CD95 death-inducing signaling complex GO:0031265 8.96 CASP8 FADD
6 cornified envelope GO:0001533 8.8 CSTA FLG LOR

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.77 CASP8 FADD IFNB1
2 response to lipopolysaccharide GO:0032496 9.73 CASP8 IL18BP TLR2
3 cornification GO:0070268 9.61 CSTA FLG LOR
4 positive regulation of tumor necrosis factor production GO:0032760 9.6 FADD TLR2
5 extrinsic apoptotic signaling pathway GO:0097191 9.58 CASP8 FADD
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 CASP8 FADD
7 T cell homeostasis GO:0043029 9.57 CORO1A FADD
8 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.55 CASP8 FADD
9 positive regulation of interleukin-8 production GO:0032757 9.54 FADD TLR2
10 natural killer cell activation GO:0030101 9.52 CASP8 IFNB1
11 positive regulation of proteolysis GO:0045862 9.51 CASP8 FADD
12 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.49 CASP8 FADD
13 positive regulation of macrophage differentiation GO:0045651 9.48 CASP8 FADD
14 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.46 CASP8 FADD
15 regulation of necroptotic process GO:0060544 9.4 CASP8 FADD
16 activation of cysteine-type endopeptidase activity GO:0097202 9.37 CASP8 FADD
17 keratinocyte differentiation GO:0030216 9.33 CSTA FLG LOR
18 skin epidermis development GO:0098773 9.32 FLG LOR
19 death-inducing signaling complex assembly GO:0071550 9.26 CASP8 FADD
20 peptide cross-linking GO:0018149 9.13 CSTA FLG LOR
21 TRAIL-activated apoptotic signaling pathway GO:0036462 8.62 CASP8 FADD

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.5 CSTA FLG LOR
2 tumor necrosis factor receptor binding GO:0005164 9.26 CASP8 FADD
3 death receptor binding GO:0005123 9.16 CASP8 FADD
4 structural constituent of epidermis GO:0030280 8.96 FLG LOR
5 death effector domain binding GO:0035877 8.62 CASP8 FADD

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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