MCID: MLL001
MIFTS: 52

Molluscum Contagiosum malady

Infectious category

Summaries for Molluscum Contagiosum

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards: Molluscum Contagiosum is related to atopic dermatitis and squamous cell carcinoma, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is LOR (loricrin), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The drug cantharidin and the compounds imidazoquinoline and collodion have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and bone marrow, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Wikipedia:64 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Aliases & Classifications for Molluscum Contagiosum

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Molluscum Contagiosum

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Clinical Features for Molluscum Contagiosum

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Molluscum Contagiosum

Drug clinical trials:

Search ClinicalTrials for Molluscum Contagiosum

Search NIH Clinical Center for Molluscum Contagiosum

Search CenterWatch for Molluscum Contagiosum

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Molluscum Contagiosum:

33
Skin, Bone marrow, Lung, Cervix, Myeloid, T cells, B lymphoblasts, B cells

FMA organs/tissues related to Molluscum Contagiosum:

14
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Molluscum Contagiosum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2TLR9, TLR7, FADD, FLG, ATG3, IL11RA
2MP:00053768.6LOR, CASP8, TLR9, TLR3, TLR7, FADD
3MP:00053878.6KRT14, LOR, CCR8, CASP8, TLR9, TLR3
4MP:00107688.6FADD, TLR7, TLR3, TLR9, CASP8, FLG
5MP:00053848.6FADD, TLR7, TLR9, CASP8, FLG, ATG3

Publications for Molluscum Contagiosum

Sources:
51PubMed
See all sources

Articles related to Molluscum Contagiosum:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Comparative study of 5% and 2.5% potassium hydroxide solution for molluscum contagiosum in children. (23713782)
2013
2
Molluscum contagiosum virus infection. (23972567)
2013
3
Dermoscopy distinction of eruptive vellus hair cysts with molluscum contagiosum and acne lesions. (22639880)
2012
4
Epibulbar molluscum contagiosum lesions in multiple myeloma. (21448067)
2011
5
Clinical characteristics of molluscum contagiosum in children in a private dermatology practice in the greater Paris area, France: a prospective study in 661 patients. (21691050)
2011
6
Molluscum contagiosum in a patient with adult T-cell leukaemia/lymphoma. (21679167)
2011
7
Molluscum contagiosum folliculitis mimicking tinea barbae in a lung transplant recipient. (20542185)
2010
8
The Incidence of Molluscum contagiosum among American Indians and Alaska Natives. (19381289)
2009
9
Prominent eosinophilic intranuclear inclusions in melanocytes of a melanocytic nevus: the aftermath of an infection with molluscum contagiosum? A case report. (18430043)
2008
10
Treatment of molluscum contagiosum: a brief review and discussion of a case successfully treated with adapelene. (18328209)
2007
11
Spreading bumps: molluscum contagiosum in the pediatric population. (18229524)
2007
12
Giant molluscum contagiosum of immunocompetent children occurring on the anogenital area. (17951137)
2007
13
Detection of Molluscum contagiosum virus (MCV) subtype I as a single dominant virus subtype in Molluscum lesions from a Turkish population. (16513490)
2006
14
Potassium titanyl phosphate (KTP) laser treatment for molluscum contagiosum. (16467023)
2006
15
Molluscum contagiosum infection after reduced-intensity cord blood transplantation. (16785862)
2006
16
Molluscum contagiosum infection during the treatment of vitiligo with tacrolimus ointment. (15761441)
2005
17
Topical salicylic acid gel as a treatment for molluscum contagiosum in children. (16428156)
2005
18
Facial eruption of molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus. (15214914)
2004
19
Molluscum contagiosum: the need for physician intervention and new treatment options. (15074350)
2004
20
Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial. (15379366)
2004
21
Molluscum contagiosum in an immune reconstituted AIDS patient. (14609853)
2003
22
Experience in treating molluscum contagiosum in children with imiquimod 5% cream. (14616342)
2003
23
Molluscum contagiosum: the importance of early diagnosis and treatment. (14532898)
2003
24
Case report: Molluscum contagiosum. Toxic shock syndrome following cantharidin treatment. (12901485)
2003
25
Molluscum contagiosum: recent advances in pathogenic mechanisms, and new therapies. (12358555)
2002
26
Molluscum contagiosum: a case series. (12422930)
2002
27
Antibodies to molluscum contagiosum virus in the general population and susceptible patients. (11115164)
2000
28
Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. (11189099)
2000
29
Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1. (10926733)
2000
30
Co-existing actinic granuloma and giant molluscum contagiosum. (11012595)
2000
31
Treatment of molluscum contagiosum with silver nitrate paste. (10571843)
1999
32
Electron-beam therapy for AIDS-related molluscum contagiosum lesions: preliminary experience. (10207432)
1999
33
National guideline for the management of molluscum contagiosum. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). (10616392)
1999
34
EMLA cream provides rapid pain relief for the curettage of molluscum contagiosum in children with atopic dermatitis without causing serious application-site reactions. (9720701)
1998
35
Inefficacy of oral cimetidine for nonatopic children with molluscum contagiosum. (9496815)
1998
36
Identification and typing of molluscum contagiosum virus in clinical specimens by polymerase chain reaction. (9365883)
1997
37
A random DNA sequencing, computer-based approach for the generation of a gene map of molluscum contagiosum virus. (9208457)
1997
38
Resolution of intractable molluscum contagiosum in a human immunodeficiency virus-infected patient after institution of antiretroviral therapy with ritonavir. (9142826)
1997
39
Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. (8938977)
1996
40
Giant molluscum contagiosum in AIDS. (8838930)
1996
41
Disseminated and atypical molluscum contagiosum in an AIDS patient. (20948109)
1996
42
Polypoidal and giant molluscum contagiosum in an AIDS patient. (7750960)
1995
43
Facial and perioral molluscum contagiosum in patients with HIV infection. A report of eight cases. (7838470)
1994
44
Molluscum contagiosum in Dutch general practice. (8790656)
1994
45
Molluscum contagiosum of the eyelid and infraorbital margin--a clinicopathologic study with light and electron microscopic observations. (8455130)
1993
46
Cutaneous cryptococcosis resembling molluscum contagiosum in a homosexual man with AIDS. Report of a case and review of the literature. (1357854)
1992
47
Molluscum contagiosum: possible culture misdiagnosis as herpes simplex. (2071135)
1991
48
Molluscum contagiosum: a neglected sentinel infection. (1782230)
1991
49
Characterization of a molluscum contagiosum virus homolog of the vaccinia virus p37K major envelope antigen. (2041084)
1991
50
Langerhans cells in molluscum contagiosum, verruca vulgaris, plantar wart, and condyloma acuminatum. (2429998)
1986

Genetic Variations for Molluscum Contagiosum

Expression for genes affiliated with Molluscum Contagiosum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 4Cell Signaling Technology, 30KEGG, 60Tocris Bioscience, 56SinoBiological
See all sources

Pathways related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2FADD, CASP8
2
Hide members
10.2FADD, CASP8
3
Apoptosis and survival Caspase cascade
Hide members
10.0CASP8, FADD, TOP1
4
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10.0FADD, TLR3, CASP8
5
Hide members
10.0TLR9, TLR3, TLR7
610.0TLR7, TLR3, TLR9
710.0TLR7, TLR3, TLR9
810.0TLR9, TLR3, TLR7
99.9IL18, FADD, TLR9, CASP8
10
Hide members
9.8IL18, TLR7, TLR3, TLR9
11
Hide members
9.8TLR9, TLR3, TLR7, IL18
129.8CASP8, TLR9, TLR3, TLR7
13
Hide members
9.8TLR9, TLR3, TLR7, FADD
14
Hide members
9.8TLR9, TLR3, TLR7, FADD
15
Hide members
9.7CCR8, CASP8, FADD, IL11RA, IL18
16
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
17
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
18
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
19
Hide members
9.6IL18, IL11RA, CASP8, CCL27, CCR8
20
Hide members
9.5CASP8, TLR9, TLR3, TLR7, FADD, IL18
21
Hide members
9.5CCR8, CCL27, CASP8, ANAPC11, IL11RA
22
Hide members
9.3CASP8, TLR9, TLR3, TLR7, FADD, ANAPC11
23
Hide members
9.1IL18, CCR8, CCL27, TLR9, TLR3, TLR7

Compounds for genes affiliated with Molluscum Contagiosum

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1imidazoquinoline4510.6TLR7, IL18
2collodion4510.5IVL, LOR
3pam2csk46010.5TLR3, TLR7
4pam3csk46010.5TLR3, TLR7
5poly(i:c)6010.5TLR3, TLR7
6loxoribine45 2911.5TLR9, TLR7
74,6-diamidino-2-phenylindole4510.4TOP1, CASP8
8epsilon-(gamma-glutamyl)lysine4510.4LOR, IVL
9dithranol4510.4FLG, IVL, KRT16
10flagellin45 2911.4IL18, TLR3, TLR9
11arsenate4510.4IVL, FLG
12ursolic acid4510.4TOP1, CASP8
13imiquimod45 29 60 1113.4IL18, TLR7, TLR3
14hematoxylin4510.4LOR, IVL, KRT14
15resiquimod45 6011.4TLR9, TLR3, TLR7
16vitamin a45 11 2412.4LOR, KRT16, KRT14
17ifn-alpha4510.3IL18, TLR3, CASP8
18mitomycin c4510.3CASP8, FADD, TOP1, IL18
19peptidoglycan45 2911.3TLR7, TLR3, TLR9
20lipoteichoic acid4510.3TLR9, TLR3, TLR7, IL18
21hydroxychloroquine45 1111.3TLR9, TLR7
22polyinosinic-polycytidylic acid4510.3TLR9, TLR3, TLR7, IL18
23calcipotriol45 60 29 1113.3KRT14, KRT16, IVL, FLG
24tarc4510.3CCR8, CCL27, IL18
25poly(i-c)4510.3IL18, TLR7, TLR3, TLR9
26ceramide4510.2CASP8, FADD, FLG, IVL
27chloroquine45 2 50 29 1114.2TLR9, TLR7, IL18
28allergens4510.2IL18, IVL, FLG, CCL27
29endotoxin4510.2TLR9, TLR3, IL18, IL18BP
30ccl345 2911.2CCR8, CCL27, TLR9, IL18
31sp 60012545 6011.2IL18, FADD, CASP8
325fluorouracil4510.1CASP8, FADD, TOP1, IVL, IL18
33retinoid4510.1CASP8, FLG, IVL, KRT16, KRT14
34sodium dodecylsulfate4510.1IVL, IL18, KRT16
35cisplatin45 50 60 1113.0CASP8, FADD, TOP1, IL18, KRT14
361,25 dihydroxy vitamin d34510.0KRT16, IL18, IVL
37doxorubicin45 50 1111.9IL18, TOP1, FADD, CASP8
38shikonin459.9TOP1, CASP8
39cholesterol45 29 11 2412.9LOR, CCL27, FADD, IVL, IL18, KRT14
40serine459.9LOR, TLR3, FLG, IVL, IL18, KRT16
41cysteine459.7CASP8, FADD, FLG, IVL, IL18, KRT14
42retinoic acid45 2410.7LOR, CASP8, TLR3, FLG, IVL, IL18
43steroid459.6LOR, FLG, IVL, IL18, KRT16
44lipid459.6LOR, CCL27, FADD, FLG, IVL, IL18
45tyrosine459.5CASP8, TLR9, TLR3, FADD, FLG, IVL

GO Terms for genes affiliated with Molluscum Contagiosum

Sources:
16Gene Ontology
See all sources

Cellular components related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:03200910.1TLR9, TLR7
2CD95 death-inducing signaling complexGO:03126510.1CASP8, FADD
3endolysosome membraneGO:03602010.0TLR7, TLR3, TLR9
4intermediate filamentGO:00588210.0KRT14, KRT16, FLG
5death-inducing signaling complexGO:0312649.9FADD, CASP8

Biological processes related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:03412310.4TLR9, TLR3
2activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
3positive regulation of interferon-alpha biosynthetic processGO:04535610.3TLR9, TLR3, TLR7
4positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR9, TLR3, TLR7
5I-kappaB phosphorylationGO:00725210.3TLR7, TLR3, TLR9
6positive regulation of interferon-gamma biosynthetic processGO:04507810.2TLR9, TLR3, TLR7
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.2CASP8, FADD
8keratinocyte differentiationGO:03021610.2IVL, FLG, LOR
9positive regulation of interleukin-6 productionGO:03275510.2TLR7, TLR3, TLR9
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.2FADD, TLR3, CASP8
11positive regulation of chemokine productionGO:03272210.2TLR9, TLR3, TLR7, IL18
12positive regulation of tumor necrosis factor productionGO:03276010.2IL18, FADD, TLR3, TLR9
13positive regulation of NF-kappaB import into nucleusGO:04234610.2IL18, TLR7, TLR3, TLR9
14MyD88-independent toll-like receptor signaling pathwayGO:00275610.2CASP8, TLR3, FADD
15positive regulation of inflammatory responseGO:05072910.1IL18, TLR7, TLR3, TLR9
16toll-like receptor 3 signaling pathwayGO:03413810.1FADD, TLR3, CASP8
17positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1FADD, TLR3, TLR9, CASP8
18cellular response to mechanical stimulusGO:07126010.1CASP8, TLR3, TLR7, FADD, IL18
19T-helper 1 type immune responseGO:04208810.1IL18, IL18BP
20positive regulation of interleukin-8 productionGO:03275710.0IL18, FADD, TLR7, TLR3, TLR9
21toll-like receptor 4 signaling pathwayGO:03414210.0FADD, TLR3, CASP8
22toll-like receptor signaling pathwayGO:00222410.0CASP8, TLR9, TLR3, TLR7, FADD
23innate immune responseGO:0450879.7TLR9, TLR3, TLR7, FADD, CASP8
24inflammatory responseGO:0069549.5IL18, TLR7, TLR3, TLR9

Molecular functions related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1siRNA bindingGO:03519710.0TLR7, TLR9
2transmembrane signaling receptor activityGO:00488810.0IL11RA, TLR3, TLR9
3structural constituent of cytoskeletonGO:0052009.7KRT14, KRT16, LOR

Products for genes affiliated with Molluscum Contagiosum

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Molluscum Contagiosum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet