MCID: MLL001
MIFTS: 42

Molluscum Contagiosum malady

Category: Infectious diseases

Aliases & Classifications for Molluscum Contagiosum

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Summaries for Molluscum Contagiosum

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CDC:2 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.

MalaCards based summary: Molluscum Contagiosum is related to hyper-ige recurrent infection syndrome, autosomal recessive and leprosy, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways are Legionellosis and Keratinization. The drug cantharidin has been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Disease Ontology:11 A viral infectious disease that results in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia:71 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin and... more...

Related Diseases for Molluscum Contagiosum

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Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

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Symptoms:

 11
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

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Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 2, Phase 38192
2CantharidinPhase 2956-25-7
3Dermatologic AgentsPhase 25806
4
Benzocaineapproved20161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
5tannic acidapproved, Nutraceutical2016

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum ContagiosumCompletedNCT01348386Phase 2, Phase 3
2Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum ContagiosumCompletedNCT02665260Phase 2
3A Study of VBP-245 in Pediatric Patients With Molluscum ContagiosumRecruitingNCT03077750Phase 2
4A Dose Range-Finding Phase 2 Trial of a Botanical Drug for the Treatment of Molluscum Contagiosum in Pediatric SubjectsRecruitingNCT02024581Phase 2
5Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of BergamoRecruitingNCT02902822Phase 2
6Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2Enrolling by invitationNCT03017846Phase 2
7Efficacy of Cantharidin in Molluscum ContagiosumCompletedNCT00667225

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

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Anatomical Context for Molluscum Contagiosum

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MalaCards organs/tissues related to Molluscum Contagiosum:

36
Skin, T cells, Cervix, Lung, Bone marrow, Myeloid, Bone

FMA organs/tissues related to Molluscum Contagiosum:

17
Skin

Publications for Molluscum Contagiosum

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Articles related to Molluscum Contagiosum:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Molluscum Contagiosum: A Rare Nipple Lesion. (27670745)
2017
2
Desmoplastic trichilemmoma dermoscopically mimicking molluscum contagiosum. (28087019)
2017
3
Corpora amylacea and molluscum contagiosum on a cervical pap smear. (27863182)
2017
4
Bulbar Conjunctival Molluscum Contagiosum. (26802706)
2016
5
Cytodiagnosis of disseminated histoplasmosis in an immunocompetent individual with molluscum contagiosum-like skin lesions and lymphadenopathy. (27756991)
2016
6
Interventions for molluscum contagiosum in people infected with human immunodeficiency virus: a systematic review. (26991246)
2016
7
Extensive molluscum contagiosum virus infection in a young adult receiving fingolimod. (26860987)
2016
8
Isolated giant molluscum contagiosum mimicking epidermoid cyst. (27648389)
2016
9
Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. (26900921)
2016
10
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. (27397059)
2016
11
Recalcitrant molluscum contagiosum successfully treated with sinecatechins. (26809498)
2016
12
Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum. (27041686)
2016
13
Pubic hair removal and molluscum contagiosum. (27278448)
2016
14
Widespread Molluscum Contagiosum with Atopic Dermatitis-like Skin Manifestations. (27534943)
2016
15
Clinical and Demographic Characteristics of Patients with Molluscum Contagiosum Treated at the University Dermatology Clinic Maribor in a 5-year period. (27477173)
2016
16
Treatment of Molluscum Contagiosum with Imiquimod in the United States: A Retrospective Cross-Sectional Study. (26608213)
2016
17
Molluscum Contagiosum Over Tattooed Skin. (27226923)
2016
18
Molluscum contagiosum of the eyelid: case report in a man receiving methotrexate and literature review of molluscum contagiosum in patients who are immunosuppressed secondary to methotrexate or HIV infection. (27136625)
2016
19
Giant Eyelid Molluscum Contagiosum in a Child with AIDS. (27549877)
2016
20
Case of disseminated molluscum contagiosum caused by ruxolitinib, a Janus kinase 1 and 2 inhibitor. (27060215)
2016
21
To Treat Molluscum Contagiosum or Not-Curettage: An Effective, Well-Accepted Treatment Modality. (27601304)
2016
22
Giant molluscum contagiosum presenting as lid neoplasm in an immunocompetent child. (26990479)
2016
23
Disseminated molluscum contagiosum following chemotherapy: A therapeutic challenge. (27852995)
2016
24
Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care. (26639950)
2016
25
Plantar Molluscum Contagiosum in an Adult Patient. (27269980)
2016
26
Molluscum Contagiosum Infection Involving a Benign Epidermoid Cyst in an Immunocompetent Patient. (27319966)
2016
27
Langerhans cell histiocytosis with molluscum contagiosum: A correlation? (28012207)
2016
28
Handheld reflectance confocal microscopy for the diagnosis of molluscum contagiosum: Histopathology and dermoscopy correlation. (27282954)
2016
29
Vascular network tightly enclosing lesions of molluscum contagiosum: Basket-like capillaries of molluscum. (27607603)
2016
30
Woronoff Ring: A Novel Manifestation of Molluscum Contagiosum. (27871346)
2016
31
Molluscum Contagiosum. (27627044)
2016
32
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. (27896283)
2016
33
Intralesional 5-fluorouracil: Novel therapy for extensive molluscum contagiosum in an immunocompetent adult. (27853002)
2016
34
Extensive molluscum contagiosum causing obstruction of vision in HIV positive woman. (27294056)
2016
35
Molluscum Contagiosum Viral Infection Treated With a Dilute Povidone-Iodine/Dimethylsulfoxide Preparation. (26690085)
2016
36
Molluscum Contagiosum Virus Transcriptome in Abortively Infected Cultured Cells and a Human Skin Lesion. (26889040)
2016
37
Dermatologists, imiquimod, and treatment of molluscum contagiosum in children: righting wrongs. (25587702)
2015
38
Molluscum contagiosum in a 12-year-old child - report of a case and review of literature. (25709372)
2015
39
Giant molluscum contagiosum with granulomatous inflammation and panniculitis: An unusual clinical and histopathological pattern in an HIV seropositive child. (26392667)
2015
40
Unique Cyst in a 22-Year-Old Man. Molluscum contagiosum in an epidermoid cyst. (26588335)
2015
41
Patient Perspectives: Molluscum Contagiosum. (26584708)
2015
42
Molluscum Contagiosum-Induced Erythema Annulare Centrifugum. (26244443)
2015
43
A comparative study of 10% KOH solution and 5% imiquimod cream for the treatment of Molluscum contagiosum in the pediatric age group. (25821725)
2015
44
Primitive follicular induction in molluscum contagiosum. (26265178)
2015
45
Atypical infantile genital Molluscum contagiosum. (26131875)
2015
46
Giant Molluscum Contagiosum in an HIV positive patient. (26255893)
2015
47
A case of Molluscum Contagiosum infection in a patient with Crohn's Disease, receiving combination therapy with azathioprine and adalimumab. (25908722)
2015
48
The natural history of molluscum contagiosum in children. (25541477)
2015
49
Histopathologic features of molluscum contagiosum other than molluscum bodies. (25891863)
2015
50
Staphylococcus lugdunensis Abscesses Complicating Molluscum Contagiosum in Two Children. (25557353)
2015

Variations for Molluscum Contagiosum

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Expression for genes affiliated with Molluscum Contagiosum

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Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

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Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.6CASP8, TLR2
2
Show member pathways
9.4CSTA, FLG, LOR
39.3CASP8, FADD
49.3CASP8, FADD
59.3CASP8, FADD
68.8CASP8, FADD, IFNB1
7
Show member pathways
8.8CASP8, FADD, TLR2
8
Show member pathways
8.3CASP8, FADD, IFNB1, TLR2
9
Show member pathways
8.3CASP8, FADD, IFNB1, TLR2
107.9CASP8, CORO1A, FADD, IFNB1, TLR2
11
Show member pathways
7.6CASP8, FADD, IFNB1, IL18BP, TLR2

GO Terms for genes affiliated with Molluscum Contagiosum

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Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.0CSTA, FLG, LOR
2CD95 death-inducing signaling complexGO:00312659.9CASP8, FADD
3death-inducing signaling complexGO:00312649.9CASP8, FADD
4cell bodyGO:00442979.4CASP8, FADD, TLR2
5ripoptosomeGO:00973429.3CASP8, FADD
6membrane raftGO:00451219.0CASP8, FADD, TLR2

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1skin epidermis developmentGO:009877310.3FLG, LOR
2natural killer cell activationGO:003010110.3CASP8, IFNB1
3cornificationGO:007026810.1CSTA, FLG, LOR
4keratinocyte differentiationGO:003021610.1CSTA, FLG, LOR
5peptide cross-linkingGO:001814910.1CSTA, FLG, LOR
6activation of cysteine-type endopeptidase activityGO:009720210.0CASP8, FADD
7activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.0CASP8, FADD
8death-inducing signaling complex assemblyGO:007155010.0CASP8, FADD
9extrinsic apoptotic signaling pathwayGO:009719110.0CASP8, FADD
10negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0CASP8, FADD
11positive regulation of macrophage differentiationGO:00456519.9CASP8, FADD
12positive regulation of proteolysisGO:00458629.9CASP8, FADD
13regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.9CASP8, FADD
14regulation of necroptotic processGO:00605449.9CASP8, FADD
15positive regulation of interleukin-8 productionGO:00327579.8FADD, TLR2
16positive regulation of tumor necrosis factor productionGO:00327609.7FADD, TLR2
17TRAIL-activated apoptotic signaling pathwayGO:00364629.7CASP8, FADD
18T cell homeostasisGO:00430299.7CORO1A, FADD
19response to lipopolysaccharideGO:00324969.5CASP8, IL18BP, TLR2
20cell surface receptor signaling pathwayGO:00071669.5CASP8, FADD, IFNB1
21TRIF-dependent toll-like receptor signaling pathwayGO:00356669.3CASP8, FADD

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of epidermisGO:003028010.5FLG, LOR
2death effector domain bindingGO:00358779.9CASP8, FADD
3death receptor bindingGO:00051239.9CASP8, FADD
4structural molecule activityGO:00051989.8CSTA, FLG, LOR
5tumor necrosis factor receptor bindingGO:00051649.3CASP8, FADD

Sources for Molluscum Contagiosum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet