MCID: MLL001
MIFTS: 54

Molluscum Contagiosum malady

Infectious diseases category

Summaries for Molluscum Contagiosum

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards: Molluscum Contagiosum is related to dermatitis and atopic dermatitis, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is LOR (loricrin), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The drug cantharidin and the compounds imidazoquinoline and collodion have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Wikipedia:63 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Aliases & Classifications for Molluscum Contagiosum

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Molluscum Contagiosum

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17GeneCards, 18GeneDecks
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Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.8LOR, CCL27, TLR9, FLG, IVL, IL18
2atopic dermatitis30.7FLG, CCL27, LOR
3herpes simplex30.7TLR9, TLR3, TLR7
4psoriasis30.5LOR, CCL27, TLR9, IFN1@, FLG, IVL
5sarcoma30.4TOP1, FADD
6papilloma30.4KRT14, IVL, FLG, LOR
7squamous cell carcinoma30.4CASP8, FADD, FLG, TOP1, IVL, KRT16
8keratoacanthoma30.2IVL
9myeloma30.2CASP8
10lichen planus30.2KRT16, IVL, FLG
11arthritis30.2TLR3, FLG, IL18
12lupus erythematosus30.2IL18, TLR7, TLR9
13hepatitis30.2CCL27, CASP8, TLR3, IL18
14asthma30.2CASP8, TLR9, TLR3, FLG, IL18, CCR8
15hepatitis b30.2CCL27, CASP8, TLR3, IFN1@, FADD, TOP1
16leukemia30.2CASP8, IFN1@, FADD, TOP1, IVL, IL11RA
17melanoma30.2CASP8, TLR9, TLR3, TLR7, TOP1, IL18BP
18rheumatoid arthritis30.2CCL27, CASP8, TLR9, TLR3, FADD, FLG
19leprosy10.6
20acquired immunodeficiency syndrome10.5
21cryptococcosis10.5
22lepromatous leprosy10.5
23basal cell carcinoma10.4
24burns10.3
25erythema multiforme10.3
26vaccinia10.3
27folliculitis10.3
28cellulitis10.3
29herpes zoster10.3
30hodgkin's lymphoma10.3
31scabies10.3
32indeterminate leprosy10.2
33cutaneous lupus erythematosus10.2
34tinea barbae10.2
35acantholytic acanthoma10.2
36job's syndrome10.2
37common wart10.2
38wiskott-aldrich syndrome10.2
39methemoglobinemia10.2
40nodular basal cell carcinoma10.2
41lichen nitidus10.2
42focal epithelial hyperplasia10.2
43kaposi's sarcoma10.2
44ecthyma10.2
45mycosis fungoides10.2
46adult lymphoma10.2
47toxic shock syndrome10.2
48vitiligo10.2
49granuloma annulare10.2
50plantar wart10.2

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Clinical Features for Molluscum Contagiosum

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8Disease Ontology
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Symptoms:

8
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Molluscum Contagiosum

Drug clinical trials:

Search ClinicalTrials for Molluscum Contagiosum

Search NIH Clinical Center for Molluscum Contagiosum

Search CenterWatch for Molluscum Contagiosum

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Molluscum Contagiosum

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Anatomical Context for Molluscum Contagiosum

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Molluscum Contagiosum:

32
Skin, T cells, Cervix, Bone marrow, Bone, Lung, Myeloid, B cells

FMA organs/tissues related to Molluscum Contagiosum:

14
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Molluscum Contagiosum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2TLR9, TLR7, FADD, FLG, ATG3, IL11RA
2MP:00053768.6LOR, CASP8, TLR9, TLR3, TLR7, FADD
3MP:00053878.6KRT14, LOR, CCR8, CASP8, TLR9, TLR3
4MP:00107688.6FADD, TLR7, TLR3, TLR9, CASP8, FLG
5MP:00053848.6FADD, TLR7, TLR9, CASP8, FLG, ATG3

Publications for Molluscum Contagiosum

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50PubMed
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Articles related to Molluscum Contagiosum:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. (22214282)
2013
2
Diagnosis of molluscum contagiosum by crater-like morphology in handheld portable digital microscopy. (24164161)
2013
3
Linear congenital molluscum contagiosum on the coccygeal region. (23146025)
2013
4
Molluscum contagiosum on the lip. (23216267)
2013
5
Kaposi sarcoma in association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic pitfall. (22262366)
2012
6
The challenges of a neglected STI: Molluscum contagiosum. (23007250)
2012
7
Methylmalonic aciduria presenting with recurrent multiple molluscum contagiosum lesions. (21547100)
2010
8
An inflammatory reaction surrounding molluscum contagiosum as possible manifestation of immune reconstitution inflammatory syndrome in HIV infection. (21078110)
2010
9
Picture of the month. Molluscum contagiosum. (19349569)
2009
10
Cantharidin use among pediatric dermatologists in the treatment of molluscum contagiosum. (19689514)
2009
11
Resolution of giant Molluscum contagiosum with antiretroviral therapy. (18583804)
2008
12
Wiskott-Aldrich syndrome and molluscum contagiosum: a therapeutic challenge after reaction to cidofovir. (19126022)
2008
13
Acantholytic acanthoma clinically resembling a molluscum contagiosum. (17207187)
2007
14
Molluscum contagiosum. (17542901)
2007
15
Treatment of multiple giant molluscum contagiosum in a renal transplant patient with imiquimod 5% cream. (16681599)
2006
16
Needling in molluscum contagiosum. (16987276)
2006
17
Interventions for cutaneous molluscum contagiosum. (16625612)
2006
18
Methemoglobinemia and CNS toxicity after topical application of EMLA to a 4-year-old girl with molluscum contagiosum. (17156008)
2006
19
Molluscum contagiosum-like lesions in lepromatous leprosy. (16044815)
2005
20
Re: "Ken and Katie caterpillar": more helpful Props for the treatment of molluscum contagiosum. (14871342)
2004
21
Conjunctival molluscum contagiosum. (14716323)
2004
22
Local molluscum contagiosum infection as a side-effect of pulsed-dye laser treatment. (15149537)
2004
23
Molluscum contagiosum. (12639455)
2003
24
Ken and Katie caterpillar: helpful props for treatment of molluscum contagiosum. (12787284)
2003
25
Secondary anetoderma following molluscum contagiosum infection. (14690344)
2003
26
Granuloma annulare masquerading as molluscum contagiosum-like eruption in an HIV-positive African woman. (12894118)
2003
27
Molluscum contagiosum from infancy to maturity. (11973052)
2002
28
Persistent molluscum contagiosum. Case study in a 6-year-old girl with asthma and eczema. (12420536)
2002
29
Indeterminate leprosy, molluscum contagiosum and nevus depigmentosus. (11898470)
2001
30
Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients. (10954663)
2000
31
Immune-defense molecules of molluscum contagiosum virus, a human poxvirus. (11044683)
2000
32
Characterization of early gene transcripts of molluscum contagiosum virus. (10208926)
1999
33
Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. (10383783)
1999
34
An immunohistochemical study of abnormal keratinocyte differentiation in molluscum contagiosum. (10417525)
1999
35
Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population. (9952381)
1999
36
Topical cidofovir for molluscum contagiosum in children. (10627225)
1999
37
Chemokine homolog of molluscum contagiosum virus: sequence conservation and expression. (9501046)
1998
38
PCR assay fails to detect molluscum contagiosum virus-related sequences in AIDS-related Kaposi's sarcoma. (9705179)
1998
39
Resolution of severe molluscum contagiosum on effective antiretroviral therapy. (9640394)
1998
40
Cutaneous pseudolymphoma in association with molluscum contagiosum. (9790119)
1998
41
Molluscum contagiosum in a soft fibroma: a particular combined lesion. (9538958)
1998
42
Sequence analysis of a Molluscum contagiosum virus DNA region which includes the gene encoding protein kinase 2 and other genes with unique organization. (8938976)
1996
43
Successful treatment of molluscum contagiosum in the immunosuppressed adult with topical injection of streptococcal preparation OK-432. (8916664)
1996
44
Molluscum contagiosum, involving the upper eyelids, in a child infected with HIV-1. (11361472)
1996
45
Molluscum contagiosum in children. (8261802)
1993
46
Stability of molluscum contagiosum virus DNA among 184 patient isolates: evidence for variability of sequences in the terminal inverted repeats. (1880497)
1991
47
Direct detection of molluscum contagiosum virus in clinical specimens by dot blot hybridization. (1774321)
1991
48
Giant molluscum contagiosum following splenectomy. (2383191)
1990
49
Treatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia. (2229496)
1990
50
Molecular epidemiology of molluscum contagiosum. (3171236)
1988

Genetic Variations for Molluscum Contagiosum

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Expression for genes affiliated with Molluscum Contagiosum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2FADD, CASP8
2
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10.2FADD, CASP8
3
Apoptosis and survival Caspase cascade
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10.0CASP8, FADD, TOP1
4
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10.0FADD, TLR3, CASP8
5
Hide members
10.0TLR9, TLR3, TLR7
610.0TLR7, TLR3, TLR9
710.0TLR7, TLR3, TLR9
810.0TLR9, TLR3, TLR7
99.9IL18, FADD, TLR9, CASP8
10
Hide members
9.8IL18, TLR7, TLR3, TLR9
11
Hide members
9.8TLR9, TLR3, TLR7, IL18
129.8CASP8, TLR9, TLR3, TLR7
13
Hide members
9.8TLR9, TLR3, TLR7, FADD
14
Hide members
9.8TLR9, TLR3, TLR7, FADD
15
Hide members
9.7CCR8, CASP8, FADD, IL11RA, IL18
16
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
17
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
18
Hide members
9.7CASP8, TLR9, TLR3, TLR7, FADD
19
Hide members
9.6IL18, IL11RA, CASP8, CCL27, CCR8
20
Hide members
9.5CASP8, TLR9, TLR3, TLR7, FADD, IL18
21
Hide members
9.5CCR8, CCL27, CASP8, ANAPC11, IL11RA
22
Hide members
9.3CASP8, TLR9, TLR3, TLR7, FADD, ANAPC11
23
Hide members
9.1IL18, CCR8, CCL27, TLR9, TLR3, TLR7

Compounds for genes affiliated with Molluscum Contagiosum

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB
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Compounds related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1imidazoquinoline4410.6TLR7, IL18
2collodion4410.5IVL, LOR
3pam2csk45910.5TLR3, TLR7
4pam3csk45910.5TLR3, TLR7
5poly(i:c)5910.5TLR3, TLR7
6loxoribine44 2811.5TLR9, TLR7
74,6-diamidino-2-phenylindole4410.4TOP1, CASP8
8epsilon-(gamma-glutamyl)lysine4410.4LOR, IVL
9dithranol4410.4FLG, IVL, KRT16
10flagellin44 2811.4IL18, TLR3, TLR9
11arsenate4410.4IVL, FLG
12ursolic acid4410.4TOP1, CASP8
13imiquimod44 28 59 1113.4IL18, TLR7, TLR3
14hematoxylin4410.4LOR, IVL, KRT14
15resiquimod44 5911.4TLR9, TLR3, TLR7
16vitamin a44 11 2412.4LOR, KRT16, KRT14
17ifn-alpha4410.3IL18, TLR3, CASP8
18mitomycin c4410.3CASP8, FADD, TOP1, IL18
19peptidoglycan44 2811.3TLR7, TLR3, TLR9
20lipoteichoic acid4410.3TLR9, TLR3, TLR7, IL18
21hydroxychloroquine44 1111.3TLR9, TLR7
22polyinosinic-polycytidylic acid4410.3TLR9, TLR3, TLR7, IL18
23calcipotriol44 59 28 1113.3KRT14, KRT16, IVL, FLG
24tarc4410.3CCR8, CCL27, IL18
25poly(i-c)4410.3IL18, TLR7, TLR3, TLR9
26ceramide4410.2CASP8, FADD, FLG, IVL
27chloroquine44 2 49 28 1114.2TLR9, TLR7, IL18
28allergens4410.2IL18, IVL, FLG, CCL27
29endotoxin4410.2TLR9, TLR3, IL18, IL18BP
30ccl344 2811.2CCR8, CCL27, TLR9, IL18
31sp 60012544 5911.2IL18, FADD, CASP8
325fluorouracil4410.1CASP8, FADD, TOP1, IVL, IL18
33retinoid4410.1CASP8, FLG, IVL, KRT16, KRT14
34sodium dodecylsulfate4410.1IVL, IL18, KRT16
35cisplatin44 49 59 1113.0CASP8, FADD, TOP1, IL18, KRT14
361,25 dihydroxy vitamin d34410.0KRT16, IL18, IVL
37doxorubicin44 49 1111.9IL18, TOP1, FADD, CASP8
38shikonin449.9TOP1, CASP8
39cholesterol44 28 11 2412.9LOR, CCL27, FADD, IVL, IL18, KRT14
40serine449.9LOR, TLR3, FLG, IVL, IL18, KRT16
41cysteine449.7CASP8, FADD, FLG, IVL, IL18, KRT14
42retinoic acid44 2410.7LOR, CASP8, TLR3, FLG, IVL, IL18
43steroid449.6LOR, FLG, IVL, IL18, KRT16
44lipid449.6LOR, CCL27, FADD, FLG, IVL, IL18
45tyrosine449.5CASP8, TLR9, TLR3, FADD, FLG, IVL

GO Terms for genes affiliated with Molluscum Contagiosum

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16Gene Ontology
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Cellular components related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:03200910.1TLR9, TLR7
2CD95 death-inducing signaling complexGO:03126510.1CASP8, FADD
3endolysosome membraneGO:03602010.0TLR7, TLR3, TLR9
4intermediate filamentGO:00588210.0KRT14, KRT16, FLG
5death-inducing signaling complexGO:0312649.9FADD, CASP8

Biological processes related to Molluscum Contagiosum according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of toll-like receptor signaling pathwayGO:03412310.4TLR9, TLR3
2activation of cysteine-type endopeptidase activityGO:09720210.4CASP8, FADD
3positive regulation of interferon-alpha biosynthetic processGO:04535610.3TLR9, TLR3, TLR7
4positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR9, TLR3, TLR7
5I-kappaB phosphorylationGO:00725210.3TLR7, TLR3, TLR9
6positive regulation of interferon-gamma biosynthetic processGO:04507810.2TLR9, TLR3, TLR7
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.2CASP8, FADD
8keratinocyte differentiationGO:03021610.2IVL, FLG, LOR
9positive regulation of interleukin-6 productionGO:03275510.2TLR7, TLR3, TLR9
10TRIF-dependent toll-like receptor signaling pathwayGO:03566610.2FADD, TLR3, CASP8
11positive regulation of chemokine productionGO:03272210.2TLR9, TLR3, TLR7, IL18
12positive regulation of tumor necrosis factor productionGO:03276010.2IL18, FADD, TLR3, TLR9
13positive regulation of NF-kappaB import into nucleusGO:04234610.2IL18, TLR7, TLR3, TLR9
14MyD88-independent toll-like receptor signaling pathwayGO:00275610.2CASP8, TLR3, FADD
15positive regulation of inflammatory responseGO:05072910.1IL18, TLR7, TLR3, TLR9
16toll-like receptor 3 signaling pathwayGO:03413810.1FADD, TLR3, CASP8
17positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1FADD, TLR3, TLR9, CASP8
18cellular response to mechanical stimulusGO:07126010.1CASP8, TLR3, TLR7, FADD, IL18
19T-helper 1 type immune responseGO:04208810.1IL18, IL18BP
20positive regulation of interleukin-8 productionGO:03275710.0IL18, FADD, TLR7, TLR3, TLR9
21toll-like receptor 4 signaling pathwayGO:03414210.0FADD, TLR3, CASP8
22toll-like receptor signaling pathwayGO:00222410.0CASP8, TLR9, TLR3, TLR7, FADD
23innate immune responseGO:0450879.7TLR9, TLR3, TLR7, FADD, CASP8
24inflammatory responseGO:0069549.5IL18, TLR7, TLR3, TLR9

Molecular functions related to Molluscum Contagiosum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1siRNA bindingGO:03519710.0TLR7, TLR9
2transmembrane signaling receptor activityGO:00488810.0IL11RA, TLR3, TLR9
3structural constituent of cytoskeletonGO:0052009.7KRT14, KRT16, LOR

Products for genes affiliated with Molluscum Contagiosum

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  • Antibodies
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Sources for Molluscum Contagiosum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet