Aliases & Classifications for Molluscum Contagiosum

Summaries for Molluscum Contagiosum

CDC : 3 Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.

MalaCards based summary : Molluscum Contagiosum is related to epidermodysplasia verruciformis and kaposi sarcoma, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll-like receptor signaling pathway. The drugs Cantharidin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has symptom lesions which are flesh-colored with a pit in the center.

Wikipedia : 72 Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results... more...

Related Diseases for Molluscum Contagiosum

Diseases related to Molluscum Contagiosum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 epidermodysplasia verruciformis 29.9 CORO1A FLG
2 kaposi sarcoma 29.3 CASP8 CCR8 IFNB1
3 hyper-ige recurrent infection syndrome, autosomal recessive 11.2
4 b-cell expansion with nfkb and t-cell anergy 11.2
5 dermatitis 10.4
6 dermatitis, atopic 10.4
7 leprosy 3 10.3
8 cryptococcosis 10.3
9 acquired immunodeficiency syndrome 10.3
10 herpes simplex 10.3
11 epidermoid cysts 10.2
12 lymphoma 10.2
13 lepromatous leprosy 10.2
14 dermatitis, atopic, 2 10.2 FLG LOR
15 ichthyosis vulgaris 10.1 FLG LOR
16 langerhans cell histiocytosis 10.1
17 basal cell carcinoma 1 10.1
18 basal cell carcinoma 10.1
19 vaccinia 10.1
20 histiocytosis 10.1
21 cellulitis 10.1
22 pustulosis of palm and sole 10.1
23 psoriasis 10.1
24 hyper ige syndrome 10.1
25 cutaneous pseudolymphoma 10.1
26 palmoplantar keratoderma, nonepidermolytic 10.1 FLG LOR
27 epidermolytic hyperkeratosis 10.0 FLG LOR
28 aging 10.0
29 episodic pain syndrome, familial, 1 10.0
30 burns 10.0
31 erythema multiforme 10.0
32 methemoglobinemia 10.0
33 sarcoma 10.0
34 anogenital venereal wart 10.0
35 histoplasmosis 10.0
36 squamous cell carcinoma 10.0
37 papilloma 10.0
38 folliculitis 10.0
39 scabies 10.0
40 herpes zoster 10.0
41 retinoblastoma 9.9
42 rheumatoid arthritis 9.9
43 focal epithelial hyperplasia, oral 9.9
44 mycosis fungoides 9.9
45 myeloma, multiple 9.9
46 surfactant metabolism dysfunction, pulmonary, 1 9.9
47 surfactant metabolism dysfunction, pulmonary, 4 9.9
48 wiskott-aldrich syndrome 9.9
49 asthma 9.9
50 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to Molluscum Contagiosum

Symptoms & Phenotypes for Molluscum Contagiosum

Symptoms:

12
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cantharidin Approved, Investigational Phase 3,Phase 2 56-25-7
2 Pharmaceutical Solutions Phase 2, Phase 3
3
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
4 tannic acid Approved, Nutraceutical
5 Dermatologic Agents

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum Completed NCT01348386 Phase 2, Phase 3 Hydroxide Potassium;Placebo
2 A Study to Evaluate the Safety and Efficacy of VP-102 in Subjects With Molluscum Not yet recruiting NCT03377803 Phase 3 VP-102;Placebo
3 A Study to Evaluate the Safety and Efficacy of VP-102 in Subjects With Molluscum Not yet recruiting NCT03377790 Phase 3 VP-102;Placebo
4 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum Completed NCT02665260 Phase 2 Cantharidin;Placebo
5 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contagiosum, Phase 2 Completed NCT03017846 Phase 2 Cantharidin
6 Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum. Recruiting NCT03186378 Phase 2 VP-102
7 A Study to Evaluate the Safety and Efficacy of SB206 in Children and Adolescents With Molluscum Contagiosum Recruiting NCT03436615 Phase 2 SB206 4%;SB206 8%;SB206 12%;Placebo
8 A Study of VBP-245 in Pediatric Patients With Molluscum Contagiosum Active, not recruiting NCT03077750 Phase 2 VBP-245 Topical Gel;Vehicle
9 A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum Terminated NCT02024581 Phase 2 10% East Indian sandalwood oil cream;Placebo Cream
10 Efficacy of Cantharidin in Molluscum Contagiosum Completed NCT00667225 cantharidin's vehicle;Cantharidin 0.7%
11 Picato for the Treatment of Molluscum Contagiosum in Immunocompromised Patients Recruiting NCT03336372 Early Phase 1 Picato
12 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

Anatomical Context for Molluscum Contagiosum

The Foundational Model of Anatomy Ontology organs/tissues related to Molluscum Contagiosum:

18
Skin

MalaCards organs/tissues related to Molluscum Contagiosum:

38
Skin, T Cells, Cervix, Lung, Bone Marrow, Myeloid, Bone

Publications for Molluscum Contagiosum

Articles related to Molluscum Contagiosum:

(show top 50) (show all 621)
# Title Authors Year
1
Cantharidin for treatment of facial molluscum contagiosum: A retrospective review. ( 29241785 )
2018
2
Expression of YAP and TAZ in molluscum contagiosum virus infected skin. ( 29330849 )
2018
3
Expanding the Morphologic Heterogeneity of Stromal Changes in Molluscum Contagiosum Infection. ( 29329128 )
2018
4
Complete resolution of facial molluscum contagiosum in a HIV-infected patient by antiretroviral therapy. ( 28971509 )
2018
5
An unusual reaction to molluscum contagiosum. ( 29319288 )
2018
6
A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. ( 29393023 )
2018
7
Autoinoculation as a treatment modality for molluscum contagiosum: A preliminary uncontrolled trial. ( 29251278 )
2018
8
Treatment of molluscum contagiosum with hydrogen peroxide. ( 29058324 )
2018
9
Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency. ( 29282454 )
2018
10
Molluscum Contagiosum ( 28722927 )
2017
11
Molluscum contagiosum: an update. ( 28521677 )
2017
12
Limited treatment options for molluscum contagiosum. ( 28768690 )
2017
13
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. ( 28845328 )
2017
14
Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2. ( 28555548 )
2017
15
Molluscum Contagiosum of the Gluteal Cleft: Observations and Implications for Management in Five Children. ( 28543922 )
2017
16
Molluscum contagiosum and pubic hair removal in male patients. ( 29027896 )
2017
17
A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. ( 28670845 )
2017
18
Topical evening primrose oil as a possible therapeutic alternative in children with molluscum contagiosum. ( 28940438 )
2017
19
Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children. ( 28871935 )
2017
20
Treatment of molluscum contagiosum with an East Indian sandalwood oil product. ( 29103323 )
2017
21
Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination. ( 28515292 )
2017
22
Molluscum Contagiosum: Review and Update on Management. ( 28884917 )
2017
23
Interventions for cutaneous molluscum contagiosum. ( 28513067 )
2017
24
Molluscum Contagiosum in a Patient with Atopic Dermatitis. ( 29166239 )
2017
25
Molluscum Contagiosum: A Rare Nipple Lesion. ( 27670745 )
2017
26
The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions. ( 28425034 )
2017
27
Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis. ( 28866311 )
2017
28
Corpora amylacea and molluscum contagiosum on a cervical pap smear. ( 27863182 )
2017
29
Melan A Antibody Cross-Reactivity in Molluscum Contagiosum Bodies. ( 28805130 )
2017
30
Molluscum Contagiosum-Like Presentation of Langerhans Cell Histiocytosis: A Case and Review. ( 28730670 )
2017
31
Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015 ( 28806866 )
2017
32
Desmoplastic trichilemmoma dermoscopically mimicking molluscum contagiosum. ( 28087019 )
2017
33
Molluscum Contagiosum Virus Protein MC005 Inhibits NF-I_B Activation by Targeting NEMO-Regulated II_B Kinase Activation. ( 28490597 )
2017
34
ELISA for Molluscum Contagiosum Virus. ( 29120484 )
2017
35
Disseminated molluscum contagiosum lesions in an HIV patient. ( 28322681 )
2017
36
Molluscum Contagiosum Treated with Dilute Povidone-Iodine: A Series of Cases. ( 28360968 )
2017
37
Recalcitrant molluscum contagiosum successfully treated with sinecatechins. ( 26809498 )
2016
38
Giant Eyelid Molluscum Contagiosum in a Child with AIDS. ( 27549877 )
2016
39
Molluscum Contagiosum Over Tattooed Skin. ( 27226923 )
2016
40
Cytodiagnosis of disseminated histoplasmosis in an immunocompetent individual with molluscum contagiosum-like skin lesions and lymphadenopathy. ( 27756991 )
2016
41
To Treat Molluscum Contagiosum or Not-Curettage: An Effective, Well-Accepted Treatment Modality. ( 27601304 )
2016
42
Disseminated molluscum contagiosum following chemotherapy: A therapeutic challenge. ( 27852995 )
2016
43
Clinical and Demographic Characteristics of Patients with Molluscum Contagiosum Treated at the University Dermatology Clinic Maribor in a 5-year period. ( 27477173 )
2016
44
Treatment of Molluscum Contagiosum with Imiquimod in the United States: A Retrospective Cross-Sectional Study. ( 26608213 )
2016
45
Molluscum Contagiosum Infection Involving a Benign Epidermoid Cyst in an Immunocompetent Patient. ( 27319966 )
2016
46
Woronoff Ring: A Novel Manifestation of Molluscum Contagiosum. ( 27871346 )
2016
47
Intralesional 5-fluorouracil: Novel therapy for extensive molluscum contagiosum in an immunocompetent adult. ( 27853002 )
2016
48
Widespread Molluscum Contagiosum with Atopic Dermatitis-like Skin Manifestations. ( 27534943 )
2016
49
Molluscum Contagiosum. ( 27627044 )
2016
50
Molluscum Contagiosum Viral Infection Treated With a Dilute Povidone-Iodine/Dimethylsulfoxide Preparation. ( 26690085 )
2016

Variations for Molluscum Contagiosum

Expression for Molluscum Contagiosum

Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for Molluscum Contagiosum

GO Terms for Molluscum Contagiosum

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell leading edge GO:0031252 8.96 CARMIL2 CORO1A
2 cornified envelope GO:0001533 8.8 CSTA FLG LOR

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.4 CASP8 IKBKG
2 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.37 CASP8 IKBKG
3 cornification GO:0070268 9.33 CSTA FLG LOR
4 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.32 CASP8 IKBKG
5 natural killer cell activation GO:0030101 9.26 CASP8 IFNB1
6 keratinocyte differentiation GO:0030216 9.13 CSTA FLG LOR
7 peptide cross-linking GO:0018149 8.8 CSTA FLG LOR

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 CSTA FLG LOR
2 structural constituent of epidermis GO:0030280 8.62 FLG LOR

Sources for Molluscum Contagiosum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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