MCID: MLL001
MIFTS: 44

Molluscum Contagiosum malady

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Molluscum Contagiosum

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Summaries for Molluscum Contagiosum

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Disease Ontology:11 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards based summary: Molluscum Contagiosum is related to lichen nitidus and asthma, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways are Ceramide signaling pathway and Syndecan-4-mediated signaling events. The drug cantharidin has been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are muscle and immune system.

Wikipedia:69 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Related Diseases for Molluscum Contagiosum

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Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Symptoms for Molluscum Contagiosum

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Symptoms:

 11
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

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Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1CantharidinPhase 2856-25-7
2
Benzocaine17941994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
3tannic acidNutraceutical1794

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum ContagiosumCompletedNCT01348386Phase 2, Phase 3
2Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum ContagiosumCompletedNCT02665260Phase 2
3A Dose Range-Finding Phase 2 Trial of a Botanical Drug for the Treatment of Molluscum Contagiosum in Pediatric SubjectsRecruitingNCT02024581Phase 2
4Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of BergamoNot yet recruitingNCT02902822Phase 2
5Efficacy of Cantharidin in Molluscum ContagiosumCompletedNCT00667225

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: molluscum contagiosum

Genetic Tests for Molluscum Contagiosum

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Anatomical Context for Molluscum Contagiosum

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MalaCards organs/tissues related to Molluscum Contagiosum:

34
Skin, T cells, Cervix, Lung, Bone marrow, Myeloid, Bone

FMA organs/tissues related to Molluscum Contagiosum:

17
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

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MGI Mouse Phenotypes related to Molluscum Contagiosum:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.2CASP8, CXCL12, CXCR4, FADD, TLR2
2MP:00053876.9CASP8, CORO1A, CXCL12, CXCR4, FADD, IFNB1
3MP:00053976.8CASP8, CORO1A, CXCL12, CXCR4, FADD, IFNB1

Publications for Molluscum Contagiosum

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Articles related to Molluscum Contagiosum:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Molluscum contagiosum of the eyelid: case report in a man receiving methotrexate and literature review of molluscum contagiosum in patients who are immunosuppressed secondary to methotrexate or HIV infection. (27136625)
2016
2
Molluscum Contagiosum Viral Infection Treated With a Dilute Povidone-Iodine/Dimethylsulfoxide Preparation. (26690085)
2016
3
Treatment of Molluscum Contagiosum with Imiquimod in the United States: A Retrospective Cross-Sectional Study. (26608213)
2016
4
Case of disseminated molluscum contagiosum caused by ruxolitinib, a Janus kinase 1 and 2 inhibitor. (27060215)
2016
5
Molluscum Contagiosum Diagnosis on Nipple Scraping Sample. (26530313)
2015
6
Atypical clinical presentation of molluscum contagiosum in an epidermal cyst. (26087091)
2015
7
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
8
Treatment of molluscum contagiosum in adult, pediatric, and immunodeficient populations. (25186990)
2014
9
Potassium hydroxide 5% for the treatment of molluscum contagiosum. (25298120)
2014
10
Dermoscopic features of molluscum contagiosum based on white structures and their correlation with histopathological findings. (25252138)
2014
11
Idiopathic CD4 lymphocytopenia presenting as recurrent giant molluscum contagiosum. (23760345)
2013
12
Unusual manifestation of molluscum contagiosum: eruptive papules on the face and neck of an immunocompetent patient. (24003298)
2013
13
An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. (22214282)
2013
14
Molluscum contagiosum: report of one case with overview. (23598933)
2013
15
Recurrent giant molluscum contagiosum immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy in an HIV-infected South African Male. (23970647)
2013
16
Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001. (22262788)
2012
17
Intraoral molluscum contagiosum in a young immunocompetent patient. (22727108)
2012
18
What is your diagnosis? Molluscum contagiosum on the sole of the foot. (21644487)
2011
19
Molluscum contagiosum in an epidermoid cyst. (21712689)
2011
20
Ulcerating molluscum contagiosum in a boy with relapsed acute lymphoblastic leukemia. (21368674)
2011
21
An immunocompromised woman with severe molluscum contagiosum that responded well to topical imiquimod: a case report and literature review. (20354423)
2010
22
Molluscum contagiosum: A 20-year study in a sexually transmitted infections unit. (20414149)
2010
23
Treatment of molluscum contagiosum with cantharidin: a practical approach. (20302243)
2010
24
Comparative study on the efficacy, safety, and acceptability of imiquimod 5% cream versus cryotherapy for molluscum contagiosum in children. (19804497)
2010
25
Topical treatment of molluscum contagiosum with imiquimod 5% cream in Turkish children. (16911087)
2006
26
Specimens from a vesicular lesion caused by molluscum contagiosum virus produced a cytopathic effect in cell culture that mimicked that produced by herpes simplex virus. (16390992)
2006
27
Treatment of molluscum contagiosum with 585 nm collagen remodeling pulsed dye laser. (15197000)
2004
28
Topical cidofovir and cryotherapy--combination treatment for recalcitrant molluscum contagiosum in a patient with HIV infection. (15009318)
2004
29
Photodynamic therapy for molluscum contagiosum infection in HIV-coinfected patients: review of 6 patients. (14711142)
2003
30
Molluscum contagiosum. (12639455)
2003
31
Molluscum contagiosum: recent advances in pathogenic mechanisms, and new therapies. (12358555)
2002
32
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. (11493620)
2001
33
Efficacy of emlap cream in children having molluscum contagiosum. (17664726)
2001
34
Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. (11210936)
2001
35
Treatment of molluscum contagiosum with topical 5% imiquimod cream. (11085678)
2000
36
Antibodies to molluscum contagiosum virus in the general population and susceptible patients. (11115164)
2000
37
Pleomorphic T-cell infiltrate associated with molluscum contagiosum. (10218681)
1999
38
Characterization of early gene transcripts of molluscum contagiosum virus. (10208926)
1999
39
DNA contacts by protein domains of the molluscum contagiosum virus type-1B topoisomerase. (10502526)
1999
40
Recalcitrant molluscum contagiosum in a patient with AIDS successfully treated by a combination of CO2-laser and natural interferon beta gel. (9689311)
1998
41
Molluscum contagiosum eyelid lesions as the initial manifestation of acquired immunodeficiency syndrome. (9262550)
1997
42
HIV-positive patient presented with giant molluscum contagiosum of the eyelid. (9420414)
1997
43
Giant molluscum contagiosum in AIDS. (8838930)
1996
44
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus. (7618282)
1995
45
Molluscum contagiosum. (7928025)
1994
46
Cutaneous cryptococcosis resembling molluscum contagiosum in a homosexual man with AIDS. Report of a case and review of the literature. (1357854)
1992
47
Molluscum contagiosum in HIV-infected patients. (1558989)
1992
48
Molluscum contagiosum: possible culture misdiagnosis as herpes simplex. (2071135)
1991
49
Molluscum contagiosum. (2366250)
1990
50
What is molluscum contagiosum? (2602309)
1989

Variations for Molluscum Contagiosum

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Expression for genes affiliated with Molluscum Contagiosum

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Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

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GO Terms for genes affiliated with Molluscum Contagiosum

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Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.1CSTA, LOR
2CD95 death-inducing signaling complexGO:00312659.9CASP8, FADD
3ripoptosomeGO:00973429.9CASP8, FADD
4death-inducing signaling complexGO:00312649.9CASP8, FADD
5cell leading edgeGO:00312529.3CORO1A, CXCR4
6cell bodyGO:00442978.9CASP8, FADD, TLR2
7membrane raftGO:00451218.8CASP8, FADD, TLR2

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1peptide cross-linkingGO:001814910.3CSTA, LOR
2T cell homeostasisGO:004302910.2CORO1A, FADD
3natural killer cell activationGO:003010110.1CASP8, IFNB1
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.1CASP8, FADD
5TRAIL-activated apoptotic signaling pathwayGO:003646210.1CASP8, FADD
6death-inducing signaling complex assemblyGO:007155010.1CASP8, FADD
7TRIF-dependent toll-like receptor signaling pathwayGO:003566610.0CASP8, FADD
8regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.0CASP8, FADD
9extrinsic apoptotic signaling pathwayGO:009719110.0CASP8, FADD
10positive regulation of macrophage differentiationGO:004565110.0CASP8, FADD
11activation of cysteine-type endopeptidase activityGO:009720210.0CASP8, FADD
12positive regulation of proteolysisGO:004586210.0CASP8, FADD
13keratinocyte differentiationGO:003021610.0CSTA, FLG, LOR
14negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9CASP8, FADD
15positive regulation of tumor necrosis factor productionGO:00327609.9FADD, TLR2
16regulation of actin polymerization or depolymerizationGO:00080649.8CORO1A, CXCL12
17positive chemotaxisGO:00509189.8CORO1A, CXCL12
18positive regulation of interleukin-8 productionGO:00327579.7FADD, TLR2
19positive regulation of oligodendrocyte differentiationGO:00487149.7CXCR4, TLR2
20regulation of calcium ion transportGO:00519249.5CXCL12, CXCR4
21telencephalon cell migrationGO:00220299.5CXCL12, CXCR4
22cell surface receptor signaling pathwayGO:00071669.2CASP8, FADD, IFNB1
23response to virusGO:00096159.0CXCL12, CXCR4, IFNB1
24response to hypoxiaGO:00016668.4CXCL12, CXCR4, TLR2
25apoptotic processGO:00069158.4CASP8, CXCR4, FADD, TLR2

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death effector domain bindingGO:003587710.0CASP8, FADD
2tumor necrosis factor receptor bindingGO:00051649.9CASP8, FADD
3structural molecule activityGO:00051989.5CSTA, FLG, LOR
4death receptor bindingGO:00051239.2CASP8, FADD

Sources for Molluscum Contagiosum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet