MCID: MLL001
MIFTS: 39

Molluscum Contagiosum malady

Infectious diseases, Skin diseases categories

Aliases & Classifications for Molluscum Contagiosum

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 2CDC, 65UMLS, 36MeSH, 29ICD9CM, 59SNOMED-CT, 27ICD10
See all sources

Summaries for Molluscum Contagiosum

About this section
Disease Ontology:10 A viral infectious disease that results in infection located in skin, has material basis in molluscum contagiosum virus, which is transmitted by contact with the skin, and transmitted by fomites. the infection has symptom lesions which are flesh-colored with a pit in the center.

MalaCards based summary: Molluscum Contagiosum is related to leprosy and cryptococcosis, and has symptoms including lesions which are flesh-colored An important gene associated with Molluscum Contagiosum is FLG (Filaggrin), and among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Ceramide signaling pathway. The drug cantharidin has been mentioned in the context of this disorder. Affiliated tissues include skin, skin and bone, and related mouse phenotype immune system.

Wikipedia:68 Molluscum contagiosum (MC) is a viral infection of the skin or occasionally of the mucous membranes,... more...

Related Diseases for Molluscum Contagiosum

About this section

Graphical network of the top 20 diseases related to Molluscum Contagiosum:



Diseases related to molluscum contagiosum

Symptoms for Molluscum Contagiosum

About this section

Symptoms:

 10
  • lesions which are flesh-colored

Drugs & Therapeutics for Molluscum Contagiosum

About this section

Drugs for Molluscum Contagiosum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Benzocaineapproved15361994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
2Cantharidin7
3tannic acidNutraceutical1536

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum ContagiosumCompletedNCT01348386Phase 2, Phase 3
2Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum ContagiosumCompletedNCT02665260Phase 2
3A Dose Range-Finding Phase 2 Trial of a Botanical Drug for the Treatment of Molluscum Contagiosum in Pediatric SubjectsNot yet recruitingNCT02024581Phase 2
4Efficacy of Cantharidin in Molluscum ContagiosumCompletedNCT00667225
5ADVN Biomarker Registry StudyTerminatedNCT00550316

Search NIH Clinical Center for Molluscum Contagiosum

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Molluscum Contagiosum

Genetic Tests for Molluscum Contagiosum

About this section

Anatomical Context for Molluscum Contagiosum

About this section

MalaCards organs/tissues related to Molluscum Contagiosum:

33
Skin, Bone, T cells, Cervix, Lung, Myeloid, Bone marrow

FMA organs/tissues related to Molluscum Contagiosum:

16
Skin

Animal Models for Molluscum Contagiosum or affiliated genes

About this section

MGI Mouse Phenotypes related to Molluscum Contagiosum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.2CASP8, CCR8, CORO1A, FADD, FLG, LOR

Publications for Molluscum Contagiosum

About this section

Articles related to Molluscum Contagiosum:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Molluscum Contagiosum Diagnosis on Nipple Scraping Sample. (26530313)
2015
2
Eruptive xanthomas masquerading as molluscum contagiosum. (24918225)
2014
3
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
4
Treatment of molluscum contagiosum in adult, pediatric, and immunodeficient populations. (25186990)
2014
5
Potassium hydroxide 5% for the treatment of molluscum contagiosum. (25298120)
2014
6
Molluscum contagiosum infection on a congenital intermediate melanocytic naevus. (25183021)
2014
7
Idiopathic CD4 lymphocytopenia presenting as recurrent giant molluscum contagiosum. (23760345)
2013
8
Unusual manifestation of molluscum contagiosum: eruptive papules on the face and neck of an immunocompetent patient. (24003298)
2013
9
Gross generalized molluscum contagiosum in a patient with autosomal recessive hyper-IgE syndrome, which resolved spontaneously after haematopoietic stem-cell transplantation. (23020750)
2013
10
Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001. (22262788)
2012
11
Molluscum contagiosum as a skin manifestation of immune reconstitution inflammatory syndrome in an AIDS patient who is receiving HAART. (22787541)
2012
12
Dermoscopic patterns of molluscum contagiosum: a study of 211 lesions confirmed by histopathology. (21437525)
2011
13
What is your diagnosis? Molluscum contagiosum on the sole of the foot. (21644487)
2011
14
Recalcitrant giant molluscum contagiosum in a patient with advanced HIV disease - eradication of disease with paclitaxel. (21245518)
2010
15
An immunocompromised woman with severe molluscum contagiosum that responded well to topical imiquimod: a case report and literature review. (20354423)
2010
16
Molluscum contagiosum: A 20-year study in a sexually transmitted infections unit. (20414149)
2010
17
Treatment of facial molluscum contagiosum with trichloroacetic acid. (19689517)
2009
18
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
19
Resolution of giant Molluscum contagiosum with antiretroviral therapy. (18583804)
2008
20
Medical Pearl: confirming the diagnosis of molluscum contagiosum using 10% potassium hydroxide. (17434028)
2007
21
Detection of Molluscum contagiosum virus (MCV) subtype I as a single dominant virus subtype in Molluscum lesions from a Turkish population. (16513490)
2006
22
Topical treatment of molluscum contagiosum with imiquimod 5% cream in Turkish children. (16911087)
2006
23
Molluscum contagiosum infection during the treatment of vitiligo with tacrolimus ointment. (15761441)
2005
24
Treatment of molluscum contagiosum with 585 nm collagen remodeling pulsed dye laser. (15197000)
2004
25
Molluscum contagiosum-like lesions in lepromatous leprosy. (15267197)
2003
26
Photodynamic therapy for molluscum contagiosum infection in HIV-coinfected patients: review of 6 patients. (14711142)
2003
27
Molluscum contagiosum. (12639455)
2003
28
Clinical profile of molluscum contagiosum in children versus adults. (14996374)
2003
29
Molluscum contagiosum: recent advances in pathogenic mechanisms, and new therapies. (12358555)
2002
30
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. (11493620)
2001
31
Efficacy of emlap cream in children having molluscum contagiosum. (17664726)
2001
32
Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. (11210936)
2001
33
Treatment of molluscum contagiosum with topical 5% imiquimod cream. (11085678)
2000
34
Pleomorphic T-cell infiltrate associated with molluscum contagiosum. (10218681)
1999
35
Characterization of early gene transcripts of molluscum contagiosum virus. (10208926)
1999
36
DNA contacts by protein domains of the molluscum contagiosum virus type-1B topoisomerase. (10502526)
1999
37
Molluscum contagiosum. (9891691)
1998
38
Recalcitrant molluscum contagiosum in a patient with AIDS successfully treated by a combination of CO2-laser and natural interferon beta gel. (9689311)
1998
39
Molluscum contagiosum eyelid lesions as the initial manifestation of acquired immunodeficiency syndrome. (9262550)
1997
40
Failure to detect human papilloma virus in cutaneous molluscum contagiosum lesions. (9494606)
1997
41
Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. (8938977)
1996
42
Expression of keratohyalin-trichohyalin hybrid granules in molluscum contagiosum. (8850037)
1996
43
Replication of molluscum contagiosum virus. (7491789)
1995
44
Molluscum contagiosum. (7928025)
1994
45
Facial and perioral molluscum contagiosum in patients with HIV infection. A report of eight cases. (7838470)
1994
46
Cutaneous cryptococcosis resembling molluscum contagiosum in a homosexual man with AIDS. Report of a case and review of the literature. (1357854)
1992
47
Molluscum contagiosum in HIV-infected patients. (1558989)
1992
48
Giant molluscum contagiosum following splenectomy. (2383191)
1990
49
Treatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia. (2229496)
1990
50
What is molluscum contagiosum? (2602309)
1989

Variations for Molluscum Contagiosum

About this section

Expression for genes affiliated with Molluscum Contagiosum

About this section
Search GEO for disease gene expression data for Molluscum Contagiosum.

Pathways for genes affiliated with Molluscum Contagiosum

About this section

Pathways related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CASP8, FADD
29.6CASP8, FADD
39.3CASP8, TLR2
4
Show member pathways
8.8CASP8, FADD, TLR2
58.3CASP8, CORO1A, FADD, TLR2

GO Terms for genes affiliated with Molluscum Contagiosum

About this section

Cellular components related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:003126410.0CASP8, FADD
2CD95 death-inducing signaling complexGO:00312659.8CASP8, FADD
3ripoptosomeGO:00973429.7CASP8, FADD
4cornified envelopeGO:00015339.7CSTA, LOR
5cell bodyGO:00442979.5CASP8, FADD

Biological processes related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complex assemblyGO:007155010.3CASP8, FADD
2activation of cysteine-type endopeptidase activityGO:009720210.2CASP8, FADD
3TRAIL-activated apoptotic signaling pathwayGO:003646210.2CASP8, FADD
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.1CASP8, FADD
5regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.1CASP8, FADD
6positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.1CASP8, FADD
7extrinsic apoptotic signaling pathwayGO:009719110.1CASP8, FADD
8regulation of necrotic cell deathGO:001093910.1CASP8, FADD
9negative regulation of necroptotic processGO:006054610.1CASP8, FADD
10necroptotic processGO:007026610.1CASP8, FADD
11programmed necrotic cell deathGO:009730010.1CASP8, FADD
12extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.1CASP8, FADD
13protein heterooligomerizationGO:005129110.0CASP8, FADD
14positive regulation of proteolysisGO:004586210.0CASP8, FADD
15T cell homeostasisGO:004302910.0CORO1A, FADD
16positive regulation of macrophage differentiationGO:00456519.9CASP8, FADD
17positive regulation of interleukin-8 productionGO:00327579.6FADD, TLR2
18keratinocyte differentiationGO:00302169.6CSTA, FLG, LOR
19positive regulation of tumor necrosis factor productionGO:00327609.5FADD, TLR2
20peptide cross-linkingGO:00181499.4CSTA, LOR
21toll-like receptor signaling pathwayGO:00022248.9CASP8, FADD, TLR2
22toll-like receptor 4 signaling pathwayGO:00341428.8CASP8, FADD, TLR2
23innate immune responseGO:00450878.3CASP8, CORO1A, FADD, TLR2

Molecular functions related to Molluscum Contagiosum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death receptor bindingGO:000512310.0CASP8, FADD
2death effector domain bindingGO:00358779.9CASP8, FADD
3tumor necrosis factor receptor bindingGO:00051649.9CASP8, FADD
4structural molecule activityGO:00051989.4CSTA, FLG, LOR

Sources for Molluscum Contagiosum

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet