MGUS
MCID: MNC006
MIFTS: 34

Monoclonal Gammopathy of Uncertain Significance (MGUS) malady

Cancer category

Summaries for Monoclonal Gammopathy of Uncertain Significance

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64Wikipedia, 33MalaCards
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Wikipedia:64 Monoclonal gammopathy of undetermined significance (MGUS , unknown or uncertain may be substituted for... more...

MalaCards: Monoclonal Gammopathy of Uncertain Significance, also known as monoclonal gammopathy of undetermined significance, is related to plasma cell leukemia and macroglobulinemia. An important gene associated with Monoclonal Gammopathy of Uncertain Significance is MAFB (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B), and among its related pathways are TGF-Beta Pathway and Immune response MIF-mediated glucocorticoid regulation. The compounds toxin-1 and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Monoclonal Gammopathy of Uncertain Significance

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

monoclonal gammopathy of uncertain significance 8 10
monoclonal gammopathy of undetermined significance 8 43 61
mgus 8 43


External Ids:

Disease Ontology8 DOID:7442
ICD1025 D47.2

Related Diseases for Monoclonal Gammopathy of Uncertain Significance

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17GeneCards, 18GeneDecks
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Diseases related to Monoclonal Gammopathy of Uncertain Significance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1plasma cell leukemia31.0IL6, NCAM1
2macroglobulinemia30.5MAG
3arthritis30.5IL6, TNF
4macroglobulinemia, waldenstrom, somatic30.1MAG
5acute leukemia30.1NCAM1
6acromegaly29.9BGLAP
7waldenstrom macroglobulinemia10.7
8fanconi syndrome10.6
9chronic neutrophilic leukemia10.6
10light chain deposition disease10.5
11smoldering myeloma10.4
12axonal neuropathy10.4
13gaucher's disease10.4
14osteomalacia10.4
15polyarteritis nodosa10.4
16hemoglobinuria10.4
17splenic tuberculosis10.4
18thrombotic thrombocytopenic purpura10.4
19bone lymphoma10.4
20pyoderma gangrenosum10.4
21kaposi's sarcoma10.4
22renal tubular acidosis10.4
23vitiligo10.4
24tuberculosis10.4
25micro syndrome10.4
26acute biphenotypic leukemia10.4
27cold agglutinin disease10.4
28b-cell lymphomas10.4
29essential thrombocythemia10.4
30kid syndrome10.4
31paroxysmal nocturnal hemoglobinuria10.4
32renal tubular acidosis, distal10.4
33familial myeloma10.4
34myeloproliferative disorder10.4
35venous thrombosis10.4
36primary renal tubular acidosis10.4
37myelodysplastic syndromes10.1
38myeloid leukemia10.0LTA
39duodenal ulcer10.0LTA
40dengue hemorrhagic fever10.0LTA
41tetanus10.0LTA
42hypertriglyceridemia10.0LTA
43cholera10.0MAG
44osteosarcoma10.0BGLAP
45growth hormone deficiency10.0BGLAP
46polyneuropathy10.0MAG
47arthropathy10.0TNF
48down syndrome10.0FGFR3
49ulcerative colitis10.0TNF
50chondrosarcoma10.0FGFR3

Graphical network of the top 20 diseases related to Monoclonal Gammopathy of Uncertain Significance:



Diseases related to monoclonal gammopathy of uncertain significance

Clinical Features for Monoclonal Gammopathy of Uncertain Significance

Drugs & Therapeutics for Monoclonal Gammopathy of Uncertain Significance

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Monoclonal Gammopathy of Uncertain Significance

Genetic Tests for Monoclonal Gammopathy of Uncertain Significance

Anatomical Context for Monoclonal Gammopathy of Uncertain Significance

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33MalaCards
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MalaCards organs/tissues related to Monoclonal Gammopathy of Uncertain Significance:

33
Bone marrow

Animal Models for Monoclonal Gammopathy of Uncertain Significance or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Monoclonal Gammopathy of Uncertain Significance:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.1FGFR3
2MP:00036319.3LTA, MAG
3MP:00053888.7IL6, FGFR3, LTA, MAFB
4MP:00053847.3TNF, NCAM1, MAFB, LTA, FGFR3, IL6
5MP:00053867.3IL6, TNF, NCAM1, MAG, MAFB, LTA

Publications for Monoclonal Gammopathy of Uncertain Significance

Genetic Variations for Monoclonal Gammopathy of Uncertain Significance

Expression for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Search GEO for disease gene expression data for Monoclonal Gammopathy of Uncertain Significance.

Pathways for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Sources:
52QIAGEN, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
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Pathways related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1LTA
29.5IL6, TNF
39.2TNF, LTA, IL6
4
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9.2TNF, LTA, IL6
5
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9.2TNF, LTA, IL6
6
Hide members
9.2IL6, LTA, TNF
79.2IL6, LTA, TNF
8
Hide members
9.2IL6, LTA, TNF
98.9SDC1, IL6, TNF
10
Hide members
8.8TNF, LTA, FGFR3, IL6
11
Hide members
8.8TNF, LTA, FGFR3, IL6
12
Hide members
8.8TNF, LTA, FGFR3, IL6
13
Hide members
8.8TNF, LTA, FGFR3, IL6
14
Hide members
8.8IL6, FGFR3, LTA, TNF
158.7IL6, MAG, TNF
168.6SDC1, MAG, NCAM1

Compounds for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1toxin-1459.9LTA, TNF
2tocilizumab45 1110.9IL6, TNF
3abatacept45 1110.9IL6, TNF
4cdp571459.9IL6, TNF
5tenidap45 2910.9IL6, TNF
6anakinra45 1110.9IL6, TNF
7taurine chloramine459.8TNF, IL6
8vesnarinone459.8TNF, IL6
9gabexate mesilate459.8IL6, TNF
10mip 1alpha459.8IL6, TNF
11flurbiprofen45 29 50 1112.8BGLAP, LTA
12pamidronate45 50 1111.7IL6, BGLAP
13clodronate45 50 1111.7IL6, BGLAP
14adalimumab45 50 1111.7IL6, TNF
15il-12459.7TNF, IL6
16tpck459.6IL6, TNF
17okt3459.6IL6, LTA, TNF
18lipoteichoic acid459.6TNF, LTA, IL6
19etanercept45 50 1111.6IL6, LTA, TNF
20il 10459.6TNF, LTA, IL6
21pentoxifylline45 1110.6TNF, LTA, IL6
22imiquimod45 29 60 1112.6IL6, TNF
23neopterin459.6TNF, LTA, IL6
24melphalan45 1110.5IL6, FGFR3, TNF
25thalidomide45 50 60 1112.5IL6, FGFR3, TNF
26neurocan459.5NCAM1, MAG
27polymyxin b459.5IL6, TNF
28tgf beta1459.5TNF, LTA, IL6
29herbimycin a45 6010.4IL6, LTA, TNF
30hydrocortisone45 2 60 1112.3IL6, TNF, BGLAP
31simvastatin45 50 60 29 11 2414.3BGLAP, TNF, IL6
32glucuronic acid459.2NCAM1, MAG
33paraffin459.2FGFR3, LTA, NCAM1, BGLAP
34zoledronic acid459.2IL6, BGLAP
35lactate459.1TNF, NCAM1, LTA, IL6
36infliximab45 50 1111.1IL6, LTA, TNF, BGLAP
37rituximab45 50 1111.1IL6, MAG, TNF
38prednisolone45 29 1111.1BGLAP, TNF, LTA, IL6
39calcitriol45 60 11 2412.1IL6, LTA, TNF, BGLAP
40rantes459.1TNF, LTA, IL6
41cyclosporin a45 29 6011.0BGLAP, TNF, LTA, IL6
42histamine45 29 2411.0BGLAP, TNF, NCAM1, IL6
43ivig458.8TNF, MAG, LTA, IL6
44retinoic acid45 249.6BGLAP, TNF, NCAM1, LTA, IL6
45dexamethasone45 50 29 1111.3BGLAP, TNF, NCAM1, LTA, FGFR3, IL6
46vegf458.3BGLAP, TNF, NCAM1, LTA, FGFR3, IL6
47lipid458.0TNF, NCAM1, MAG, LTA, FGFR3, IL6
48serine457.9BGLAP, TNF, NCAM1, MAG, LTA, FGFR3

GO Terms for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Sources:
16Gene Ontology
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Cellular components related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2SDC1, IL6, NCAM1, TNF
2extracellular regionGO:0055767.6TNF, NCAM1, FGFR3, IL6, SDC1, BGLAP

Biological processes related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8TNF, LTA
3negative regulation of growth of symbiont in hostGO:0441309.8LTA, TNF
4negative regulation of lipid storageGO:0108889.7IL6, TNF
5epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7IL6, TNF
6positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6IL6, FGFR3
7positive regulation of chemokine productionGO:0327229.6TNF, IL6
8negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
9response to activityGO:0148239.5TNF, BGLAP
10defense response to Gram-positive bacteriumGO:0508309.5TNF, LTA, IL6
11humoral immune responseGO:0069599.4IL6, LTA, TNF
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.3TNF, FGFR3, IL6
13response to mechanical stimulusGO:0096129.3BGLAP, TNF, IL6
14odontogenesisGO:0424769.2BGLAP, SDC1
15positive regulation of nitric oxide biosynthetic processGO:0454299.2IL6, TNF
16positive regulation of apoptotic processGO:0430659.0IL6, FGFR3, LTA, TNF
17response to drugGO:0424938.9BGLAP, TNF, LTA, IL6
18response to glucocorticoid stimulusGO:0513848.7SDC1, IL6, TNF, BGLAP

Molecular functions related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.6LTA, TNF
2cytokine activityGO:0051258.9IL6, LTA, TNF

Products for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Sources for Monoclonal Gammopathy of Uncertain Significance

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet