MCID: MNC006
MIFTS: 40

Monoclonal Gammopathy of Uncertain Significance malady

Rare diseases, Cancer diseases categories

Summaries for Monoclonal Gammopathy of Uncertain Significance

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Wikipedia:63 Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for... more...

MalaCards based summary: Monoclonal Gammopathy of Uncertain Significance, also known as monoclonal gammopathy of undetermined significance, is related to plasma cell leukemia and multiple myeloma. An important gene associated with Monoclonal Gammopathy of Uncertain Significance is MAFB (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B), and among its related pathways are Prion diseases and Cellular Transformation by HTLV1. The compounds toxin-1 and neurocan have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related mouse phenotypes are respiratory system and vision/eye.

Aliases & Classifications for Monoclonal Gammopathy of Uncertain Significance

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Monoclonal Gammopathy of Uncertain Significance, Aliases & Descriptions:

Name: Monoclonal Gammopathy of Uncertain Significance 9 11
Monoclonal Gammopathy of Undetermined Significance 9 41 60
 
Mgus 9 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:7442
ICD1025 D47.2

Related Diseases for Monoclonal Gammopathy of Uncertain Significance

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Diseases related to Monoclonal Gammopathy of Uncertain Significance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1plasma cell leukemia31.1NCAM1, IL6
2multiple myeloma30.7FGFR3, IL6, NCAM1
3leukemia30.4TNF, LTA, FGFR3, NCAM1, IL6
4psoriasis30.4TNF, LTA, IL6
5arthritis30.3IL6, TNF, LTA
6myeloma30.3LTA, NCAM1, MAG, IL6, FGFR3
7keratopathy10.6
8amyloidosis10.6
9neuropathy10.6
10al amyloidosis10.6
11chronic neutrophilic leukemia10.6
12cryoglobulinemia10.6
13fanconi syndrome10.6
14smoldering myeloma10.6
15polyneuropathy10.6
16light chain deposition disease10.6
17myelodysplastic syndrome10.4
18polycythemia vera10.4
19aspergillosis10.4
20obesity10.4
21macroglobulinemia, waldenstrom, somatic10.4
22acute biphenotypic leukemia10.4
23acute leukemia10.4
24b-cell lymphomas10.4
25chronic inflammatory demyelinating polyneuropathy10.4
26diffuse large b-cell lymphoma10.4
27lymphedema10.4
28paroxysmal nocturnal hemoglobinuria10.4
29renal tubular acidosis10.4
30waldenstrom macroglobulinemia10.4
31gaucher's disease10.4
32diffuse idiopathic skeletal hyperostosis10.4
33fragile x-associated tremor/ataxia syndrome10.4
34thrombotic thrombocytopenic purpura10.4
35axonal neuropathy10.4
36acromegaly10.4
37splenic tuberculosis10.4
38polyarteritis nodosa10.4
39osteomalacia10.4
40pyoderma gangrenosum10.4
41invasive aspergillosis10.4
42demyelinating polyneuropathy10.4
43hemoglobinuria10.4
44histiocytosis10.4
45hyperostosis10.4
46kidney disease10.4
47pericarditis10.4
48polycythemia10.4
49polyradiculoneuropathy10.4
50pyoderma10.4

Graphical network of the top 20 diseases related to Monoclonal Gammopathy of Uncertain Significance:



Diseases related to monoclonal gammopathy of uncertain significance

Symptoms for Monoclonal Gammopathy of Uncertain Significance

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Drugs & Therapeutics for Monoclonal Gammopathy of Uncertain Significance

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Drug clinical trials:

Search ClinicalTrials for Monoclonal Gammopathy of Uncertain Significance

Search NIH Clinical Center for Monoclonal Gammopathy of Uncertain Significance

Genetic Tests for Monoclonal Gammopathy of Uncertain Significance

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Anatomical Context for Monoclonal Gammopathy of Uncertain Significance

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MalaCards organs/tissues related to Monoclonal Gammopathy of Uncertain Significance:

31
Bone, Bone marrow, Testes

Animal Models for Monoclonal Gammopathy of Uncertain Significance or affiliated genes

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MGI Mouse Phenotypes related to Monoclonal Gammopathy of Uncertain Significance:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4TNF, IL6, MAFB, LTA, FGFR3
2MP:00053918.3TNF, IL6, NCAM1, LTA, FGFR3
3MP:00053908.3TNF, IL6, MAFB, LTA, FGFR3
4MP:00107718.1FGFR3, IL6, SDC1, TNF
5MP:00020068.0FGFR3, IL6, SDC1, TNF
6MP:00053797.9TNF, SDC1, IL6, MAFB, LTA
7MP:00053877.6TNF, SDC1, IL6, MAFB, LTA, FGFR3
8MP:00053867.5FGFR3, TNF, IL6, MAG, MAFB, NCAM1
9MP:00036317.5TNF, IL6, MAG, MAFB, NCAM1, LTA
10MP:00053847.4TNF, SDC1, IL6, MAFB, NCAM1, FGFR3
11MP:00053977.4TNF, SDC1, IL6, LTA, FGFR3
12MP:00053767.4TNF, SDC1, IL6, MAFB, LTA, FGFR3
13MP:00107687.2TNF, SDC1, IL6, MAFB, NCAM1, LTA

Publications for Monoclonal Gammopathy of Uncertain Significance

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Articles related to Monoclonal Gammopathy of Uncertain Significance:

(show all 12)
idTitleAuthorsYear
1
Autoantibodies against U1RNP and monoclonal gammopathy of uncertain significance: an unusual association. (19772812)
2009
2
Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance. (17535272)
2007
3
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. (17576818)
2007
4
Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions. (15455229)
2005
5
Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. (15049904)
2004
6
Prevalence of hepatitis C virus infection in IgM-type monoclonal gammopathy of uncertain significance and WaldenstrAPm macroglobulinemia. (15551289)
2004
7
Myeloma and monoclonal gammopathy of uncertain significance associated with acquired von Willebrand's syndrome. Seven new cases with a literature review. (11858359)
2002
8
Interleukin 6, tumour necrosis factor alpha and lymphotoxin alpha polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. (11167813)
2001
9
Late blood pool images after Tc-99m tetrofosmin injection in a patient with monoclonal gammopathy of uncertain significance and immunologic disorders. (10885696)
2000
10
Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. (9763553)
1998
11
Bone remodelling in monoclonal gammopathies of uncertain significance, symptomatic and nonsymptomatic myeloma. (8853167)
1996
12
Erosive arthritis in monoclonal gammopathy of uncertain significance: report of four cases. (1747145)
1991

Variations for Monoclonal Gammopathy of Uncertain Significance

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Expression for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Search GEO for disease gene expression data for Monoclonal Gammopathy of Uncertain Significance.

Pathways for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Pathways related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NCAM1, IL6
2
Show member pathways
9.5TNF, LTA
39.3TNF, IL6
49.3TNF, IL6
59.3IL6, TNF
69.3IL6, TNF
79.3IL6, TNF
89.3IL6, TNF
99.3IL6, TNF
109.3IL6, TNF
11
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0TNF, IL6, LTA
129.0TNF, IL6, LTA
139.0TNF, IL6, LTA
14
Show member pathways
9.0LTA, IL6, TNF
15
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0LTA, IL6, TNF
169.0LTA, IL6, TNF
17
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0LTA, IL6, TNF
18
Show member pathways
IL27-mediated signaling events36
9.0TNF, IL6, LTA
19
Show member pathways
9.0TNF, IL6, LTA
20
Show member pathways
8.9TNF, IL6, FGFR3
218.8MAG, IL6, TNF
228.7SDC1, MAG, NCAM1
23
Show member pathways
8.5FGFR3, LTA, IL6, TNF
24
Show member pathways
8.5FGFR3, LTA, IL6, TNF
25
Show member pathways
8.5TNF, IL6, LTA, FGFR3
26
Show member pathways
8.5TNF, IL6, LTA, FGFR3
27
Show member pathways
8.5TNF, IL6, LTA, FGFR3
28
Show member pathways
8.5TNF, IL6, LTA, FGFR3
29
Show member pathways
8.5TNF, IL6, LTA, FGFR3
308.5IL6, SDC1, TNF

Compounds for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Compounds related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1toxin-1439.8LTA, TNF
2neurocan439.8NCAM1, MAG
3tocilizumab43 1210.8TNF, IL6
4abatacept43 1210.7IL6, TNF
5cdp571439.7TNF, IL6
6tenidap43 2810.7TNF, IL6
7anakinra43 1210.7IL6, TNF
8taurine chloramine439.7IL6, TNF
9vesnarinone439.7IL6, TNF
10cyclosporine49 1210.7TNF, LTA
11gabexate mesilate439.7IL6, TNF
12ulinastatin439.7IL6, TNF
13mip 1alpha439.7IL6, TNF
14glucuronic acid439.7NCAM1, MAG
15il-12439.6IL6, TNF
16adalimumab43 49 1211.6TNF, IL6
17tpck439.6IL6, TNF
18imiquimod43 59 28 1212.6IL6, TNF
19polymyxin b439.4TNF, IL6
20okt3439.4TNF, IL6, LTA
21lipoteichoic acid439.4LTA, IL6, TNF
22leflunomide43 49 1211.4IL6, TNF
23etanercept43 49 1211.4LTA, IL6, TNF
24il 10439.4LTA, IL6, TNF
25infliximab43 49 1211.4LTA, IL6, TNF
26pentoxifylline43 1210.4TNF, IL6, LTA
27neopterin439.4LTA, IL6, TNF
28prednisolone43 28 1211.4LTA, IL6, TNF
29tgf beta1439.4LTA, IL6, TNF
30melphalan43 49 1211.3FGFR3, IL6, TNF
31herbimycin a43 5910.3TNF, IL6, LTA
32groalpha439.3IL6, TNF
33thalidomide43 49 59 1212.3FGFR3, IL6, TNF
34triptolide439.3IL6, TNF
35endotoxin439.3TNF, IL6, LTA
36calcitriol43 59 24 1212.3LTA, IL6, TNF
37rituximab43 49 1211.2TNF, IL6, MAG
38indomethacin43 28 59 1212.2LTA, IL6, TNF
39threonine439.0MAG, NCAM1, LTA, FGFR3
40lactate438.9LTA, NCAM1, IL6, TNF
41ivig438.9LTA, MAG, IL6, TNF
42acetylcholine43 49 28 24 1212.8LTA, NCAM1, MAG
43nitric oxide43 24 1210.8LTA, NCAM1, IL6, TNF
44histamine43 28 2410.8TNF, IL6, NCAM1
45retinoic acid43 249.7TNF, IL6, NCAM1, LTA
46dexamethasone43 49 28 1211.5TNF, IL6, NCAM1, LTA, FGFR3
47vegf438.5TNF, IL6, NCAM1, LTA, FGFR3
48tyrosine438.5IL6, MAG, NCAM1, LTA, FGFR3
49serine438.4TNF, MAG, NCAM1, LTA, FGFR3
50lipid438.0TNF, IL6, MAG, NCAM1, LTA, FGFR3

GO Terms for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Cellular components related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.7TNF, NCAM1, FGFR3
2extracellular regionGO:00055768.5FGFR3, NCAM1, IL6, TNF
3external side of plasma membraneGO:00098978.0NCAM1, IL6, SDC1, TNF

Biological processes related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, FGFR3
2positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.9LTA, TNF
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00029259.8LTA, TNF
4negative regulation of growth of symbiont in hostGO:00441309.8LTA, TNF
5positive regulation of interferon-gamma productionGO:00327299.7LTA, TNF
6substantia nigra developmentGO:00217629.7FGFR3, MAG
7epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.7TNF, IL6
8negative regulation of lipid storageGO:00108889.7TNF, IL6
9positive regulation of chemokine productionGO:00327229.7IL6, TNF
10positive regulation of nitric oxide biosynthetic processGO:00454299.6IL6, TNF
11positive regulation of neuron apoptotic processGO:00435259.6TNF, FGFR3
12negative regulation of fat cell differentiationGO:00455999.6IL6, TNF
13positive regulation of interleukin-6 productionGO:00327559.6IL6, TNF
14positive regulation of smooth muscle cell proliferationGO:00486619.5TNF, IL6
15positive regulation of peptidyl-serine phosphorylationGO:00331389.4IL6, TNF
16positive regulation of MAPK cascadeGO:00434109.4FGFR3, IL6
17defense response to Gram-positive bacteriumGO:00508309.3LTA, IL6, TNF
18response to mechanical stimulusGO:00096129.3TNF, IL6
19positive regulation of protein kinase B signalingGO:00518979.3IL6, TNF
20humoral immune responseGO:00069599.3LTA, IL6, TNF
21positive regulation of ERK1 and ERK2 cascadeGO:00703749.3FGFR3, IL6, TNF
22positive regulation of apoptotic processGO:00430659.3LTA, IL6, TNF
23response to drugGO:00424939.3TNF, IL6, LTA
24response to calcium ionGO:00515929.2IL6, SDC1
25MAPK cascadeGO:00001659.1FGFR3, TNF
26response to glucocorticoidGO:00513848.9TNF, SDC1, IL6
27extracellular matrix organizationGO:00301988.8TNF, SDC1, NCAM1
28inflammatory responseGO:00069548.8IL6, SDC1, TNF

Molecular functions related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.5LTA, TNF
2cytokine activityGO:00051258.7LTA, IL6, TNF

Products for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Sources for Monoclonal Gammopathy of Uncertain Significance

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3CDC
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22GTR
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet