MGUS
MCID: MNC006
MIFTS: 42

Monoclonal Gammopathy of Uncertain Significance (MGUS) malady

Cancer diseases category

Summaries for Monoclonal Gammopathy of Uncertain Significance

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63Wikipedia, 32MalaCards
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Wikipedia:63 Monoclonal gammopathy of undetermined significance (MGUS , unknown or uncertain may be substituted for... more...

MalaCards: Monoclonal Gammopathy of Uncertain Significance, also known as monoclonal gammopathy of undetermined significance, is related to myeloma and multiple myeloma. An important gene associated with Monoclonal Gammopathy of Uncertain Significance is MAFB (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B), and among its related pathways are TGF-Beta Pathway and Immune response MIF-mediated glucocorticoid regulation. The compounds toxin-1 and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Monoclonal Gammopathy of Uncertain Significance

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8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

monoclonal gammopathy of uncertain significance 8 10
monoclonal gammopathy of undetermined significance 8 42 60
mgus 8 42


External Ids:

Disease Ontology8 DOID:7442
ICD1025 D47.2

Related Diseases for Monoclonal Gammopathy of Uncertain Significance

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Monoclonal Gammopathy of Uncertain Significance:



Diseases related to monoclonal gammopathy of uncertain significance

Clinical Features for Monoclonal Gammopathy of Uncertain Significance

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Drugs & Therapeutics for Monoclonal Gammopathy of Uncertain Significance

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Monoclonal Gammopathy of Uncertain Significance

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Anatomical Context for Monoclonal Gammopathy of Uncertain Significance

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32MalaCards
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MalaCards organs/tissues related to Monoclonal Gammopathy of Uncertain Significance:

32
Bone, Bone marrow, Testes

Animal Models for Monoclonal Gammopathy of Uncertain Significance or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Monoclonal Gammopathy of Uncertain Significance:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.1FGFR3
2MP:00036319.3LTA, MAG
3MP:00053888.7IL6, FGFR3, LTA, MAFB
4MP:00053847.3TNF, NCAM1, MAFB, LTA, FGFR3, IL6
5MP:00053867.3IL6, TNF, NCAM1, MAG, MAFB, LTA

Publications for Monoclonal Gammopathy of Uncertain Significance

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50PubMed
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Articles related to Monoclonal Gammopathy of Uncertain Significance:

(show all 12)
idTitleAuthorsYear
1
Autoantibodies against U1RNP and monoclonal gammopathy of uncertain significance: an unusual association. (19772812)
2009
2
Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance. (17535272)
2007
3
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. (17576818)
2007
4
Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions. (15455229)
2005
5
Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. (15049904)
2004
6
Prevalence of hepatitis C virus infection in IgM-type monoclonal gammopathy of uncertain significance and WaldenstrAPm macroglobulinemia. (15551289)
2004
7
Myeloma and monoclonal gammopathy of uncertain significance associated with acquired von Willebrand's syndrome. Seven new cases with a literature review. (11858359)
2002
8
Interleukin 6, tumour necrosis factor alpha and lymphotoxin alpha polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. (11167813)
2001
9
Late blood pool images after Tc-99m tetrofosmin injection in a patient with monoclonal gammopathy of uncertain significance and immunologic disorders. (10885696)
2000
10
Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. (9763553)
1998
11
Bone remodelling in monoclonal gammopathies of uncertain significance, symptomatic and nonsymptomatic myeloma. (8853167)
1996
12
Erosive arthritis in monoclonal gammopathy of uncertain significance: report of four cases. (1747145)
1991

Genetic Variations for Monoclonal Gammopathy of Uncertain Significance

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Expression for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Search GEO for disease gene expression data for Monoclonal Gammopathy of Uncertain Significance.

Pathways for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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51QIAGEN, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1LTA
29.5IL6, TNF
39.2TNF, LTA, IL6
4
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9.2TNF, LTA, IL6
5
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9.2TNF, LTA, IL6
6
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9.2IL6, LTA, TNF
79.2IL6, LTA, TNF
8
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9.2IL6, LTA, TNF
98.9SDC1, IL6, TNF
10
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8.8TNF, LTA, FGFR3, IL6
11
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8.8TNF, LTA, FGFR3, IL6
12
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8.8TNF, LTA, FGFR3, IL6
13
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8.8TNF, LTA, FGFR3, IL6
14
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8.8IL6, FGFR3, LTA, TNF
158.7IL6, MAG, TNF
168.6SDC1, MAG, NCAM1

Compounds for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1toxin-1449.9LTA, TNF
2tocilizumab44 1110.9IL6, TNF
3abatacept44 1110.9IL6, TNF
4cdp571449.9IL6, TNF
5tenidap44 2810.9IL6, TNF
6anakinra44 1110.9IL6, TNF
7taurine chloramine449.8TNF, IL6
8vesnarinone449.8TNF, IL6
9gabexate mesilate449.8IL6, TNF
10mip 1alpha449.8IL6, TNF
11flurbiprofen44 28 49 1112.8BGLAP, LTA
12pamidronate44 49 1111.7IL6, BGLAP
13clodronate44 49 1111.7IL6, BGLAP
14adalimumab44 49 1111.7IL6, TNF
15il-12449.7TNF, IL6
16tpck449.6IL6, TNF
17okt3449.6IL6, LTA, TNF
18lipoteichoic acid449.6TNF, LTA, IL6
19etanercept44 49 1111.6IL6, LTA, TNF
20il 10449.6TNF, LTA, IL6
21pentoxifylline44 1110.6TNF, LTA, IL6
22imiquimod44 28 59 1112.6IL6, TNF
23neopterin449.6TNF, LTA, IL6
24melphalan44 1110.5IL6, FGFR3, TNF
25thalidomide44 49 59 1112.5IL6, FGFR3, TNF
26neurocan449.5NCAM1, MAG
27polymyxin b449.5IL6, TNF
28tgf beta1449.5TNF, LTA, IL6
29herbimycin a44 5910.4IL6, LTA, TNF
30hydrocortisone44 2 59 1112.3IL6, TNF, BGLAP
31simvastatin44 49 59 28 11 2414.3BGLAP, TNF, IL6
32glucuronic acid449.2NCAM1, MAG
33paraffin449.2FGFR3, LTA, NCAM1, BGLAP
34zoledronic acid449.2IL6, BGLAP
35lactate449.1TNF, NCAM1, LTA, IL6
36infliximab44 49 1111.1IL6, LTA, TNF, BGLAP
37rituximab44 49 1111.1IL6, MAG, TNF
38prednisolone44 28 1111.1BGLAP, TNF, LTA, IL6
39calcitriol44 59 11 2412.1IL6, LTA, TNF, BGLAP
40rantes449.1TNF, LTA, IL6
41cyclosporin a44 28 5911.0BGLAP, TNF, LTA, IL6
42histamine44 28 2411.0BGLAP, TNF, NCAM1, IL6
43ivig448.8TNF, MAG, LTA, IL6
44retinoic acid44 249.6BGLAP, TNF, NCAM1, LTA, IL6
45dexamethasone44 49 28 1111.3BGLAP, TNF, NCAM1, LTA, FGFR3, IL6
46vegf448.3BGLAP, TNF, NCAM1, LTA, FGFR3, IL6
47lipid448.0TNF, NCAM1, MAG, LTA, FGFR3, IL6
48serine447.9BGLAP, TNF, NCAM1, MAG, LTA, FGFR3

GO Terms for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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16Gene Ontology
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Cellular components related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.2SDC1, IL6, NCAM1, TNF
2extracellular regionGO:0055767.6TNF, NCAM1, FGFR3, IL6, SDC1, BGLAP

Biological processes related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8TNF, LTA
3negative regulation of growth of symbiont in hostGO:0441309.8LTA, TNF
4negative regulation of lipid storageGO:0108889.7IL6, TNF
5epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7IL6, TNF
6positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6IL6, FGFR3
7positive regulation of chemokine productionGO:0327229.6TNF, IL6
8negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
9response to activityGO:0148239.5TNF, BGLAP
10defense response to Gram-positive bacteriumGO:0508309.5TNF, LTA, IL6
11humoral immune responseGO:0069599.4IL6, LTA, TNF
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.3TNF, FGFR3, IL6
13response to mechanical stimulusGO:0096129.3BGLAP, TNF, IL6
14odontogenesisGO:0424769.2BGLAP, SDC1
15positive regulation of nitric oxide biosynthetic processGO:0454299.2IL6, TNF
16positive regulation of apoptotic processGO:0430659.0IL6, FGFR3, LTA, TNF
17response to drugGO:0424938.9BGLAP, TNF, LTA, IL6
18response to glucocorticoid stimulusGO:0513848.7SDC1, IL6, TNF, BGLAP

Molecular functions related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.6LTA, TNF
2cytokine activityGO:0051258.9IL6, LTA, TNF

Products for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Sources for Monoclonal Gammopathy of Uncertain Significance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet