MGUS
MCID: MNC006
MIFTS: 47

Monoclonal Gammopathy of Uncertain Significance (MGUS) malady

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Summaries for Monoclonal Gammopathy of Uncertain Significance

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65Wikipedia, 33MalaCards
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Wikipedia:65 Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for... more...

MalaCards: Monoclonal Gammopathy of Uncertain Significance, also known as monoclonal gammopathy of undetermined significance, is related to leukemia and plasma cell leukemia. An important gene associated with Monoclonal Gammopathy of Uncertain Significance is MAFB (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B), and among its related pathways are Prion diseases and Cellular Transformation by HTLV1. The compounds toxin-1 and neurocan have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related mouse phenotypes are respiratory system and vision/eye.

Aliases & Classifications for Monoclonal Gammopathy of Uncertain Significance

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8Disease Ontology, 10DISEASES, 43NIH Rare Diseases, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

monoclonal gammopathy of uncertain significance 8 10
monoclonal gammopathy of undetermined significance 8 43 62
mgus 8 43


External Ids:

Disease Ontology8 DOID:7442
ICD1025 D47.2

Related Diseases for Monoclonal Gammopathy of Uncertain Significance

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Monoclonal Gammopathy of Uncertain Significance:



Diseases related to monoclonal gammopathy of uncertain significance

Symptoms for Monoclonal Gammopathy of Uncertain Significance

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Drugs & Therapeutics for Monoclonal Gammopathy of Uncertain Significance

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Monoclonal Gammopathy of Uncertain Significance

Search NIH Clinical Center for Monoclonal Gammopathy of Uncertain Significance

Genetic Tests for Monoclonal Gammopathy of Uncertain Significance

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Anatomical Context for Monoclonal Gammopathy of Uncertain Significance

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33MalaCards
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MalaCards organs/tissues related to Monoclonal Gammopathy of Uncertain Significance:

33
Bone, Bone marrow, Testes

Animal Models for Monoclonal Gammopathy of Uncertain Significance or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Monoclonal Gammopathy of Uncertain Significance:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4TNF, IL6, MAFB, LTA, FGFR3
2MP:00053918.3TNF, IL6, NCAM1, LTA, FGFR3
3MP:00053908.3TNF, IL6, MAFB, LTA, FGFR3
4MP:00107718.1FGFR3, IL6, SDC1, TNF
5MP:00020068.0FGFR3, IL6, SDC1, TNF
6MP:00053797.9TNF, SDC1, IL6, MAFB, LTA
7MP:00053877.6TNF, SDC1, IL6, MAFB, LTA, FGFR3
8MP:00053867.5FGFR3, TNF, IL6, MAG, MAFB, NCAM1
9MP:00036317.5TNF, IL6, MAG, MAFB, NCAM1, LTA
10MP:00053847.4TNF, SDC1, IL6, MAFB, NCAM1, FGFR3
11MP:00053977.4TNF, SDC1, IL6, LTA, FGFR3
12MP:00053767.4TNF, SDC1, IL6, MAFB, LTA, FGFR3
13MP:00107687.2TNF, SDC1, IL6, MAFB, NCAM1, LTA

Publications for Monoclonal Gammopathy of Uncertain Significance

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52PubMed
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Articles related to Monoclonal Gammopathy of Uncertain Significance:

(show all 12)
idTitleAuthorsYear
1
Autoantibodies against U1RNP and monoclonal gammopathy of uncertain significance: an unusual association. (19772812)
2009
2
Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance. (17535272)
2007
3
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. (17576818)
2007
4
Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions. (15455229)
2005
5
Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. (15049904)
2004
6
Prevalence of hepatitis C virus infection in IgM-type monoclonal gammopathy of uncertain significance and WaldenstrAPm macroglobulinemia. (15551289)
2004
7
Myeloma and monoclonal gammopathy of uncertain significance associated with acquired von Willebrand's syndrome. Seven new cases with a literature review. (11858359)
2002
8
Interleukin 6, tumour necrosis factor alpha and lymphotoxin alpha polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. (11167813)
2001
9
Late blood pool images after Tc-99m tetrofosmin injection in a patient with monoclonal gammopathy of uncertain significance and immunologic disorders. (10885696)
2000
10
Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. (9763553)
1998
11
Bone remodelling in monoclonal gammopathies of uncertain significance, symptomatic and nonsymptomatic myeloma. (8853167)
1996
12
Erosive arthritis in monoclonal gammopathy of uncertain significance: report of four cases. (1747145)
1991

Variations for Monoclonal Gammopathy of Uncertain Significance

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Expression for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Search GEO for disease gene expression data for Monoclonal Gammopathy of Uncertain Significance.

Pathways for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 55Reactome
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Pathways related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NCAM1, IL6
2
Show member pathways
9.5TNF, LTA
39.3TNF, IL6
49.3TNF, IL6
59.3IL6, TNF
69.3IL6, TNF
79.3IL6, TNF
89.3IL6, TNF
99.3IL6, TNF
109.3IL6, TNF
11
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0TNF, IL6, LTA
129.0TNF, IL6, LTA
139.0TNF, IL6, LTA
14
Show member pathways
9.0LTA, IL6, TNF
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0LTA, IL6, TNF
169.0LTA, IL6, TNF
17
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0LTA, IL6, TNF
18
Show member pathways
IL27-mediated signaling events38
9.0TNF, IL6, LTA
19
Show member pathways
9.0TNF, IL6, LTA
20
Show member pathways
8.9TNF, IL6, FGFR3
218.8MAG, IL6, TNF
228.7SDC1, MAG, NCAM1
23
Show member pathways
8.5FGFR3, LTA, IL6, TNF
24
Show member pathways
8.5FGFR3, LTA, IL6, TNF
25
Show member pathways
8.5TNF, IL6, LTA, FGFR3
26
Show member pathways
8.5TNF, IL6, LTA, FGFR3
27
Show member pathways
8.5TNF, IL6, LTA, FGFR3
28
Show member pathways
8.5TNF, IL6, LTA, FGFR3
29
Show member pathways
8.5TNF, IL6, LTA, FGFR3
308.5IL6, SDC1, TNF

Compounds for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1toxin-1459.8LTA, TNF
2neurocan459.8NCAM1, MAG
3tocilizumab45 1110.8TNF, IL6
4abatacept45 1110.7IL6, TNF
5cdp571459.7TNF, IL6
6tenidap45 2910.7TNF, IL6
7anakinra45 1110.7IL6, TNF
8taurine chloramine459.7IL6, TNF
9vesnarinone459.7IL6, TNF
10cyclosporine51 1110.7TNF, LTA
11gabexate mesilate459.7IL6, TNF
12ulinastatin459.7IL6, TNF
13mip 1alpha459.7IL6, TNF
14glucuronic acid459.7NCAM1, MAG
15il-12459.6IL6, TNF
16adalimumab45 51 1111.6TNF, IL6
17tpck459.6IL6, TNF
18imiquimod45 61 29 1112.6IL6, TNF
19polymyxin b459.4TNF, IL6
20okt3459.4TNF, IL6, LTA
21lipoteichoic acid459.4LTA, IL6, TNF
22leflunomide45 51 1111.4IL6, TNF
23etanercept45 51 1111.4LTA, IL6, TNF
24il 10459.4LTA, IL6, TNF
25infliximab45 51 1111.4LTA, IL6, TNF
26pentoxifylline45 1110.4TNF, IL6, LTA
27neopterin459.4LTA, IL6, TNF
28prednisolone45 29 1111.4LTA, IL6, TNF
29tgf beta1459.4LTA, IL6, TNF
30melphalan45 51 1111.3FGFR3, IL6, TNF
31herbimycin a45 6110.3TNF, IL6, LTA
32groalpha459.3IL6, TNF
33thalidomide45 51 61 1112.3FGFR3, IL6, TNF
34gm-csf45 2910.3IL6, TNF
35endotoxin459.3TNF, IL6, LTA
36calcitriol45 61 24 1112.3LTA, IL6, TNF
37rituximab45 51 1111.2TNF, IL6, MAG
38indomethacin45 29 61 1112.2LTA, IL6, TNF
39threonine459.0MAG, NCAM1, LTA, FGFR3
40lactate458.9LTA, NCAM1, IL6, TNF
41ivig458.9LTA, MAG, IL6, TNF
42acetylcholine45 51 29 24 1112.8LTA, NCAM1, MAG
43nitric oxide45 24 1110.8LTA, NCAM1, IL6, TNF
44histamine45 29 2410.8TNF, IL6, NCAM1
45retinoic acid45 249.7TNF, IL6, NCAM1, LTA
46dexamethasone45 51 29 1111.5TNF, IL6, NCAM1, LTA, FGFR3
47vegf458.5TNF, IL6, NCAM1, LTA, FGFR3
48tyrosine458.5IL6, MAG, NCAM1, LTA, FGFR3
49serine458.4TNF, MAG, NCAM1, LTA, FGFR3
50lipid458.0TNF, IL6, MAG, NCAM1, LTA, FGFR3

GO Terms for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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16Gene Ontology
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Cellular components related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.7TNF, NCAM1, FGFR3
2extracellular regionGO:0055768.5FGFR3, NCAM1, IL6, TNF
3external side of plasma membraneGO:0098978.0NCAM1, IL6, SDC1, TNF

Biological processes related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9IL6, FGFR3
2positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8LTA, TNF
4negative regulation of growth of symbiont in hostGO:0441309.8LTA, TNF
5positive regulation of interferon-gamma productionGO:0327299.7LTA, TNF
6substantia nigra developmentGO:0217629.7FGFR3, MAG
7epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7TNF, IL6
8negative regulation of lipid storageGO:0108889.7TNF, IL6
9positive regulation of chemokine productionGO:0327229.7IL6, TNF
10positive regulation of nitric oxide biosynthetic processGO:0454299.6IL6, TNF
11positive regulation of neuron apoptotic processGO:0435259.6TNF, FGFR3
12negative regulation of fat cell differentiationGO:0455999.6IL6, TNF
13positive regulation of interleukin-6 productionGO:0327559.6IL6, TNF
14positive regulation of smooth muscle cell proliferationGO:0486619.5TNF, IL6
15positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, TNF
16positive regulation of MAPK cascadeGO:0434109.4FGFR3, IL6
17defense response to Gram-positive bacteriumGO:0508309.3LTA, IL6, TNF
18response to mechanical stimulusGO:0096129.3TNF, IL6
19positive regulation of protein kinase B signalingGO:0518979.3IL6, TNF
20humoral immune responseGO:0069599.3LTA, IL6, TNF
21positive regulation of ERK1 and ERK2 cascadeGO:0703749.3FGFR3, IL6, TNF
22positive regulation of apoptotic processGO:0430659.3LTA, IL6, TNF
23response to drugGO:0424939.3TNF, IL6, LTA
24response to calcium ionGO:0515929.2IL6, SDC1
25MAPK cascadeGO:0001659.1FGFR3, TNF
26response to glucocorticoidGO:0513848.9TNF, SDC1, IL6
27extracellular matrix organizationGO:0301988.8TNF, SDC1, NCAM1
28inflammatory responseGO:0069548.8IL6, SDC1, TNF

Molecular functions related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
2cytokine activityGO:0051258.7LTA, IL6, TNF

Products for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Sources for Monoclonal Gammopathy of Uncertain Significance

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
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37MGI
40NCIt
41NDF-RT
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48OMIM via Orphanet
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59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet