MGUS
MCID: MNC006
MIFTS: 47

Monoclonal Gammopathy of Uncertain Significance (MGUS) malady

Rare diseases, Cancer diseases categories
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Summaries for Monoclonal Gammopathy of Uncertain Significance

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MalaCards based summary: Monoclonal Gammopathy of Uncertain Significance, also known as monoclonal gammopathy of undetermined significance, is related to plasma cell leukemia and multiple myeloma. An important gene associated with Monoclonal Gammopathy of Uncertain Significance is MAFB (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B), and among its related pathways are Prion diseases and Cellular Transformation by HTLV1. The compounds toxin-1 and neurocan have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related mouse phenotypes are respiratory system and vision/eye.

Aliases & Classifications for Monoclonal Gammopathy of Uncertain Significance

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Monoclonal Gammopathy of Uncertain Significance, Aliases & Descriptions:

Name: Monoclonal Gammopathy of Uncertain Significance 8 10 62
Monoclonal Gammopathy of Undetermined Significance 8 42 62
 
Mgus 8 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:7442
ICD1025 D47.2

Related Diseases for Monoclonal Gammopathy of Uncertain Significance

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Diseases related to Monoclonal Gammopathy of Uncertain Significance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1plasma cell leukemia31.1NCAM1, IL6
2multiple myeloma30.7FGFR3, NCAM1, IL6
3psoriasis30.4LTA, IL6, TNF
4arthritis30.4LTA, IL6, TNF
5myeloma30.3IL6, MAG, NCAM1, LTA, FGFR3
6leukemia29.3TNF, IL6, NCAM1, LTA, FGFR3
7al amyloidosis10.6
8chronic neutrophilic leukemia10.6
9fanconi syndrome10.6
10light chain deposition disease10.6
11acute biphenotypic leukemia10.4
12chronic inflammatory demyelinating polyneuropathy10.4
13lymphedema10.4
14obesity10.4
15paroxysmal nocturnal hemoglobinuria10.4
16renal tubular acidosis10.4
17vitiligo10.4
18waldenstrom macroglobulinemia10.4
19axonal neuropathy10.4
20gaucher's disease10.4
21hemoglobinuria10.4
22splenic tuberculosis10.4
23polyarteritis nodosa10.4
24thrombotic thrombocytopenic purpura10.4
25osteomalacia10.4
26pyoderma gangrenosum10.4
27kaposi's sarcoma10.4
28demyelinating polyneuropathy10.4
29histiocytosis10.4
30kidney disease10.4
31pericarditis10.4
32pyoderma10.4
33sarcoma10.4
34tuberculosis10.4
35chromosome 13q deletion10.4
36cold agglutinin disease10.4
37essential thrombocythemia10.4
38venous thrombosis10.4
39endotheliitis10.4
40hemangioma10.4
41hepatitis10.4
42hepatitis c10.4
43macroglobulinemia10.4
44purpura10.4
45acquired von willebrand syndrome10.4
46hepatitis c virus10.4
47psoriatic arthritis10.4TNF
48crohn's disease10.3TNF
49optic neuritis10.3MAG, LTA
50skin disease10.2IL6

Graphical network of the top 20 diseases related to Monoclonal Gammopathy of Uncertain Significance:



Diseases related to monoclonal gammopathy of uncertain significance

Symptoms for Monoclonal Gammopathy of Uncertain Significance

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Drugs & Therapeutics for Monoclonal Gammopathy of Uncertain Significance

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Drug clinical trials:

Search ClinicalTrials for Monoclonal Gammopathy of Uncertain Significance

Search NIH Clinical Center for Monoclonal Gammopathy of Uncertain Significance

Genetic Tests for Monoclonal Gammopathy of Uncertain Significance

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Anatomical Context for Monoclonal Gammopathy of Uncertain Significance

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MalaCards organs/tissues related to Monoclonal Gammopathy of Uncertain Significance:

32
Bone, Bone marrow, Testes

Animal Models for Monoclonal Gammopathy of Uncertain Significance or affiliated genes

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MGI Mouse Phenotypes related to Monoclonal Gammopathy of Uncertain Significance:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4TNF, IL6, MAFB, LTA, FGFR3
2MP:00053918.3TNF, IL6, NCAM1, LTA, FGFR3
3MP:00053908.3TNF, IL6, MAFB, LTA, FGFR3
4MP:00107718.1FGFR3, IL6, SDC1, TNF
5MP:00020068.0FGFR3, IL6, SDC1, TNF
6MP:00053797.9TNF, SDC1, IL6, MAFB, LTA
7MP:00053877.6TNF, SDC1, IL6, MAFB, LTA, FGFR3
8MP:00053867.5FGFR3, TNF, IL6, MAG, MAFB, NCAM1
9MP:00036317.5TNF, IL6, MAG, MAFB, NCAM1, LTA
10MP:00053847.4TNF, SDC1, IL6, MAFB, NCAM1, FGFR3
11MP:00053977.4TNF, SDC1, IL6, LTA, FGFR3
12MP:00053767.4TNF, SDC1, IL6, MAFB, LTA, FGFR3
13MP:00107687.2TNF, SDC1, IL6, MAFB, NCAM1, LTA

Publications for Monoclonal Gammopathy of Uncertain Significance

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Articles related to Monoclonal Gammopathy of Uncertain Significance:

(show all 12)
idTitleAuthorsYear
1
Autoantibodies against U1RNP and monoclonal gammopathy of uncertain significance: an unusual association. (19772812)
2009
2
Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance. (17535272)
2007
3
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. (17576818)
2007
4
Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions. (15455229)
2005
5
Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. (15049904)
2004
6
Prevalence of hepatitis C virus infection in IgM-type monoclonal gammopathy of uncertain significance and WaldenstrAPm macroglobulinemia. (15551289)
2004
7
Myeloma and monoclonal gammopathy of uncertain significance associated with acquired von Willebrand's syndrome. Seven new cases with a literature review. (11858359)
2002
8
Interleukin 6, tumour necrosis factor alpha and lymphotoxin alpha polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. (11167813)
2001
9
Late blood pool images after Tc-99m tetrofosmin injection in a patient with monoclonal gammopathy of uncertain significance and immunologic disorders. (10885696)
2000
10
Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. (9763553)
1998
11
Bone remodelling in monoclonal gammopathies of uncertain significance, symptomatic and nonsymptomatic myeloma. (8853167)
1996
12
Erosive arthritis in monoclonal gammopathy of uncertain significance: report of four cases. (1747145)
1991

Variations for Monoclonal Gammopathy of Uncertain Significance

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Expression for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Expression patterns in normal tissues for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

Search GEO for disease gene expression data for Monoclonal Gammopathy of Uncertain Significance.

Pathways for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Pathways related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NCAM1, IL6
2
Show member pathways
9.5TNF, LTA
39.3TNF, IL6
49.3TNF, IL6
59.3IL6, TNF
69.3IL6, TNF
79.3IL6, TNF
89.3IL6, TNF
99.3IL6, TNF
109.3IL6, TNF
11
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0TNF, IL6, LTA
129.0TNF, IL6, LTA
139.0TNF, IL6, LTA
14
Show member pathways
9.0LTA, IL6, TNF
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0LTA, IL6, TNF
169.0LTA, IL6, TNF
17
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0LTA, IL6, TNF
18
Show member pathways
IL27-mediated signaling events37
9.0TNF, IL6, LTA
19
Show member pathways
9.0TNF, IL6, LTA
20
Show member pathways
8.9TNF, IL6, FGFR3
218.8MAG, IL6, TNF
228.7SDC1, MAG, NCAM1
23
Show member pathways
8.5FGFR3, LTA, IL6, TNF
24
Show member pathways
8.5FGFR3, LTA, IL6, TNF
25
Show member pathways
8.5TNF, IL6, LTA, FGFR3
26
Show member pathways
8.5TNF, IL6, LTA, FGFR3
27
Show member pathways
8.5TNF, IL6, LTA, FGFR3
28
Show member pathways
8.5TNF, IL6, LTA, FGFR3
29
Show member pathways
8.5TNF, IL6, LTA, FGFR3
308.5IL6, SDC1, TNF

Compounds for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Compounds related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1toxin-1449.8LTA, TNF
2neurocan449.8NCAM1, MAG
3tocilizumab44 1110.8IL6, TNF
4abatacept44 1110.7IL6, TNF
5cdp571449.7TNF, IL6
6tenidap44 2810.7TNF, IL6
7anakinra44 1110.7IL6, TNF
8vesnarinone449.7TNF, IL6
9taurine chloramine449.7IL6, TNF
10cyclosporine50 1110.7LTA, TNF
11gabexate mesilate449.7IL6, TNF
12ulinastatin449.7IL6, TNF
13mip 1alpha449.7TNF, IL6
14glucuronic acid449.7NCAM1, MAG
15il-12449.6TNF, IL6
16adalimumab44 50 1111.6IL6, TNF
17imiquimod44 61 28 1112.6IL6, TNF
18tpck449.6IL6, TNF
19polymyxin b449.4IL6, TNF
20okt3449.4TNF, IL6, LTA
21lipoteichoic acid449.4TNF, IL6, LTA
22groalpha449.4IL6, TNF
23etanercept44 50 1111.4IL6, TNF, LTA
24il 10449.4TNF, IL6, LTA
25infliximab44 50 1111.4TNF, IL6, LTA
26pentoxifylline44 1110.4TNF, IL6, LTA
27neopterin449.4TNF, IL6, LTA
28prednisolone44 28 1111.4LTA, TNF, IL6
29tgf beta1449.4TNF, IL6, LTA
30melphalan44 50 1111.3FGFR3, TNF, IL6
31herbimycin a44 6110.3IL6, TNF, LTA
32leflunomide44 50 1111.3TNF, IL6
33thalidomide44 50 61 1112.3FGFR3, TNF, IL6
34gm-csf44 2810.3IL6, TNF
35endotoxin449.3TNF, IL6, LTA
36calcitriol44 61 24 1112.3LTA, IL6, TNF
37rituximab44 50 1111.2IL6, MAG, TNF
38indomethacin44 28 61 1112.2TNF, LTA, IL6
39threonine449.0MAG, LTA, FGFR3, NCAM1
40lactate448.9TNF, IL6, NCAM1, LTA
41ivig448.9MAG, TNF, LTA, IL6
42acetylcholine44 50 28 24 1112.8MAG, NCAM1, LTA
43nitric oxide44 24 1110.8LTA, NCAM1, TNF, IL6
44histamine44 28 2410.8NCAM1, IL6, TNF
45retinoic acid44 249.7NCAM1, LTA, IL6, TNF
46dexamethasone44 50 28 1111.5LTA, NCAM1, IL6, FGFR3, TNF
47vegf448.5FGFR3, TNF, LTA, IL6, NCAM1
48tyrosine448.5IL6, MAG, LTA, FGFR3, NCAM1
49serine448.4LTA, MAG, FGFR3, TNF, NCAM1
50lipid448.0LTA, IL6, FGFR3, TNF, MAG, NCAM1

GO Terms for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Cellular components related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.7TNF, NCAM1, FGFR3
2extracellular regionGO:0055768.5FGFR3, NCAM1, IL6, TNF
3external side of plasma membraneGO:0098978.0NCAM1, IL6, SDC1, TNF

Biological processes related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9IL6, FGFR3
2positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.9LTA, TNF
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.8LTA, TNF
4negative regulation of growth of symbiont in hostGO:0441309.8LTA, TNF
5positive regulation of interferon-gamma productionGO:0327299.7LTA, TNF
6substantia nigra developmentGO:0217629.7FGFR3, MAG
7epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7TNF, IL6
8negative regulation of lipid storageGO:0108889.7TNF, IL6
9positive regulation of chemokine productionGO:0327229.7IL6, TNF
10positive regulation of nitric oxide biosynthetic processGO:0454299.6IL6, TNF
11positive regulation of neuron apoptotic processGO:0435259.6TNF, FGFR3
12negative regulation of fat cell differentiationGO:0455999.6IL6, TNF
13positive regulation of interleukin-6 productionGO:0327559.6IL6, TNF
14positive regulation of smooth muscle cell proliferationGO:0486619.5TNF, IL6
15positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, TNF
16positive regulation of MAPK cascadeGO:0434109.4FGFR3, IL6
17defense response to Gram-positive bacteriumGO:0508309.3LTA, IL6, TNF
18response to mechanical stimulusGO:0096129.3TNF, IL6
19positive regulation of protein kinase B signalingGO:0518979.3IL6, TNF
20humoral immune responseGO:0069599.3LTA, IL6, TNF
21positive regulation of ERK1 and ERK2 cascadeGO:0703749.3FGFR3, IL6, TNF
22positive regulation of apoptotic processGO:0430659.3LTA, IL6, TNF
23response to drugGO:0424939.3TNF, IL6, LTA
24response to calcium ionGO:0515929.2IL6, SDC1
25MAPK cascadeGO:0001659.1FGFR3, TNF
26response to glucocorticoidGO:0513848.9TNF, SDC1, IL6
27extracellular matrix organizationGO:0301988.8TNF, SDC1, NCAM1
28inflammatory responseGO:0069548.8IL6, SDC1, TNF

Molecular functions related to Monoclonal Gammopathy of Uncertain Significance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5LTA, TNF
2cytokine activityGO:0051258.7LTA, IL6, TNF

Products for genes affiliated with Monoclonal Gammopathy of Uncertain Significance

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Sources for Monoclonal Gammopathy of Uncertain Significance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet