MCID: MNC007
MIFTS: 59

Monocytic Leukemia malady

Cancer diseases category

Summaries for Monocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

MalaCards: Monocytic Leukemia, also known as schilling's leukemia, is related to leukemia and acute monocytic leukemia. An important gene associated with Monocytic Leukemia is KAT6B (K(lysine) acetyltransferase 6B), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Monocytic Leukemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

monocytic leukemia 8 44 60
schilling's leukemia 8


External Ids:

Disease Ontology8 DOID:8527
ICD9CM27 206.8
ICD1025 C93

Related Diseases for Monocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
monocytic leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9AFF1, MPO, MLLT10, CRAT, CREBBP, TNF
2acute monocytic leukemia31.7THBD, RARA, NME1, CD300LF, CD14, CD40
3acute leukemia31.7CSF2, CSF1, CREBBP, MLLT10, MPO, AFF1
4myeloid leukemia30.5CREBBP, CSF1, CSF2, JUN, CRAT, MLLT10
5sarcoma30.5EP300, CSF1
6t-cell leukemia30.4CREBBP, JUN, CRAT, CD40, EP300
7acute lymphocytic leukemia30.3CREBBP, EP300, AFF1, MPO, MLLT10, CSF2
8retinoblastoma30.2NME1, JUN, CREBBP, CRAT, EP300, RARA
9myeloma30.2RARA, CD40, CD14, CSF1, CSF2
10respiratory failure30.2TNF
11hepatocellular carcinoma29.9CRAT, JUN, CD14, NME1, RARA
12neutropenia29.9CSF1, CSF2, CD40, MPO
13letterer-siwe disease29.9RARA, CSF1, CD40
14tuberculosis29.9TNF, CRAT
15obesity29.9RARA, TNF
16multiple myeloma29.9CD40
17neuroblastoma29.9NME1
18sarcoidosis29.9CD14, TNF
19proteinuria29.9MPO, RARA
20leukostasis29.9MPO
21chronic monocytic leukemia10.5
22aleukemic monocytic leukemia cutis10.4
23childhood leukemia10.4
24subacute monocytic leukemia10.4
25acute t cell leukemia10.3
26aleukemic leukemia cutis10.3
27histiocytosis10.3
28testicular leukemia10.3
29acute myeloid leukemia10.3
30subacute leukemia10.2
31central nervous system leukemia10.2
32lymphoblastic leukemia10.2
33myelofibrosis10.2
34mast-cell leukemia10.1
35infectious mononucleosis10.1
36malignant histiocytosis10.1
37gingivitis10.1
38hairy cell leukemia10.1
39lactic acidosis10.1
40melanoma10.0CD14, EP300, IL8, NME1, CRAT, RARA
41ipex syndrome10.0TNF, CD40, CREBBP, EP300, JUN, NUP98
42atherosclerosis10.0JUN, THBD, IL8, CD14, CD40, MPO
43asthma10.0IL8, CD14, MPO, JUN, TNF, CSF1
44acute promyelocytic leukemia10.0JUN, CSF1, EP300, MPO, CREBBP, THBD
45myelodysplastic syndromes10.0CSF2, CSF1, CREBBP, MPO, NUP98, EP300
46hematologic cancer10.0MLLT10, NUP98, CREBBP, RARA, CSF2, CSF1
47osteosarcoma10.0RARA, NME1, EP300, CSF1, JUN, CRAT
48choriocarcinoma10.0JUN, CSF1, CRAT, CREBBP, RARA, CSF2
49alzheimer's disease10.0CD40, JUN, RARA, EP300, CRAT, CREBBP
50rheumatoid arthritis10.0TNF, IL8, JUN, CSF2, CSF1, MPO

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to monocytic leukemia

Clinical Features for Monocytic Leukemia

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Drugs & Therapeutics for Monocytic Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Monocytic Leukemia

Search NIH Clinical Center for Monocytic Leukemia

Search CenterWatch for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

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Anatomical Context for Monocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Monocytic Leukemia:

32
Monocytes, Myeloid, Bone, T cells, Skin, Bone marrow, B cells, Spinal cord, Liver, Prostate, Endothelial, Pituitary, Testes, Spleen, Lung, Nk cells

Animal Models for Monocytic Leukemia or affiliated genes

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36MGI
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Publications for Monocytic Leukemia

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50PubMed
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Articles related to Monocytic Leukemia:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage. (24270736)
2013
2
Peripheral blood lymphocyte and monocyte recovery and survival in acute leukemia postmyeloablative allogeneic hematopoietic stem cell transplant. (21843495)
2012
3
Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers. (21163322)
2011
4
Nonapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on interleukin-6, leukemia inhibitory factor, interleukin-8, and monocyte chemoattractant protein 1 vary between undifferentiated and decidualized human endometrial stromal cells. (19476940)
2009
5
Significance of transmission electron microscopy in subtyping of monocytic leukemia. (19274583)
2009
6
Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. (19330074)
2008
7
Extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma: a clinicopathologic and immunophenotype analysis of 5 cases]. (18509981)
2008
8
Leukemia cutis in a patient with acute monocytic leukemia presenting as unique facial erythema. (19017048)
2008
9
Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction. (17996095)
2007
10
In vitro stimulation of specific antileukemia T-cell response by dendritic cells derived from CD14+ acute monocytic leukemia cells]. (16552959)
2005
11
A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. (15951289)
2005
12
C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia. (12529666)
2003
13
Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia. (12645654)
2003
14
A novel therapeutic strategy against monocytic leukemia with deoxyadenosine analogs and adenosine deaminase inhibitors. (11697650)
2001
15
Novel synthesized trimannose conjugate induces endocytosis and expression of immunostimulatory molecules in monocytic leukemia cells. (11721968)
2001
16
Human monocytic ehrlichiosis in a child with leukemia. (10694014)
2000
17
Vidarabine and 2-deoxycoformycin as antileukemic agents against monocytic leukemia. (10975384)
2000
18
Priming effects of macrophage colony-stimulating factor on monocytic leukemia cells in combination with chemotherapy: induction of programmed cell death in vivo. (10784404)
2000
19
Fluorescence in situ hybridization characterization of the chromosomal breakpoints in a case with ins(17;3)(q11.2;q21q26.3) and acute monocytic leukemia. (9797776)
1998
20
Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. (9478929)
1998
21
Anticoagulant effects of 1alpha,25-dihydroxyvitamin D3 on human myelogenous leukemia cells and monocytes. (9639512)
1998
22
Regulation of vimentin expression and protease-mediated vimentin degradation during differentiation of human monocytic leukemia cells. (9247605)
1997
23
c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells. (9264404)
1997
24
Aleukemic "leukemia cutis" of monocytic lineage. (9146562)
1997
25
Acute megakaryo-monocytic leukemia with acute myelofibrosis. (8892748)
1996
26
Integrin signaling to NF-kappa B in monocytic leukemia cells is blocked by activated oncogenes. (8625304)
1996
27
Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line. (8412297)
1993
28
Macrophage colony-stimulating factor stimulates growth progression of the G1-phase fraction and induces monocytic differentiation of the G2/M-phase fraction in human myeloid leukemia cells. (8405241)
1993
29
A novel translocation, t(9;11)(q33;q23) involving the HRX gene in an acute monocytic leukemia. (8019892)
1993
30
Chromosome painting in acute monocytic leukemia. (7680885)
1993
31
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers. (1324788)
1992
32
A phorbol diester resistant monocytic leukemia cell line is PKC deficient. (1313072)
1992
33
Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor. (1700006)
1990
34
Secretion of an interleukin 1-like activity by acute monocytic leukemia cells which inhibits growth of fibroblasts. (1966989)
1990
35
Neurofibromatosis and acute monocytic leukemia in adults. (2507124)
1989
36
Demonstration of IL-1 alpha, and IL-1 beta secretion by the monocytic leukemia cell line, THP-1. (2507640)
1989
37
Leukemia cutis in acute monocytic leukemia. (2743811)
1989
38
Induction of adenosine deaminase and 5' nucleotidase activity in cultured human blood monocytes and monocytic leukemia (THP-1) cells by differentiating agents. (2842422)
1988
39
Acute monocytic leukemia in children. Response to VP-16-213 as a single agent. (3326651)
1987
40
Expression of tissue transglutaminase in cultured monocytic leukemia (THP-1) cells during differentiation. (2867824)
1986
41
Acute monocytic leukemia presenting in the eyelid. An immunohistochemical and electron microscopic study. (3468454)
1986
42
Characterization of a colony-stimulating factor produced by the human monocytic leukemia cell line, THP-1. (3485167)
1986
43
Induction of differentiation of cultured mouse monocytic leukemia cells (Mm-A) by inducers different from those of parent myeloblastic leukemia cells (M1). (3936826)
1985
44
Acute monocytic leukemia chromosome studies. (6951102)
1982
45
Giant granules and rod-shaped inclusions arising de novo in monocytes and macrophages cultured from a patient with acute monocytic leukemia. (6293332)
1982
46
Monocytic leukemia in a 2-year-old child. (6948410)
1982
47
Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations. (57715)
1976
48
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
49
Acute monocytic leukemia: report of a case treated with cortisone and 6-mercaptopurine. (13281687)
1956
50
Acute monocytic leukemia. (20996103)
1946

Genetic Variations for Monocytic Leukemia

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Expression for genes affiliated with Monocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monocytic Leukemia

Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for genes affiliated with Monocytic Leukemia

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7JUN, CSF2, CSF1, TNF, CREBBP, EP300
2
Hide members
10.7RARA, CSF2, CSF1, CREBBP, CD40, CD14
3
Hide members
10.7JUN, TNF, CREBBP, CD40, CD14, EP300
4
Hide members
10.7JUN, CSF2, CREBBP, NUP98, CD40, CD14
510.7CSF2, MPO, AFF1, CD40, CD14, IL8
610.7JUN, CSF2, TNF, CREBBP, CD40, EP300
7
Hide members
10.7JUN, TNF, CREBBP, CD14, EP300, IL8
8
Hide members
10.7IL8, CREBBP, TNF, CSF1, CSF2, JUN
910.7RARA, NME1, EP300, CREBBP, TNF, JUN
10
Hide members
10.7JUN, TNF, CREBBP, NUP98, EP300, IL8
11
Hide members
10.6EP300, CD14, CREBBP, TNF, JUN
12
Hide members
10.6JUN, TNF, CD14, EP300, IL8
1310.6JUN, CSF2, CREBBP, EP300, IL8
14
Hide members
10.6IL8, EP300, CREBBP, TNF, JUN
1510.6JUN, TNF, CREBBP, EP300, IL8
1610.6JUN, CREBBP, EP300, IL8, RARA
1710.6CD14, TNF, CSF1, CSF2
1810.6EP300, CD40, CREBBP, JUN
1910.6JUN, CREBBP, CD40, EP300
2010.6TNF, CREBBP, CD14, EP300
2110.6TNF, CD40, CD14, IL8
2210.6THBD, IL8, EP300, JUN
2310.6JUN, CSF2, CD14, IL8
2410.6JUN, CSF2, CREBBP, EP300
2510.6TNF, CSF1, CSF2, JUN
2610.6CSF2, TNF, CD14, IL8
2710.6JUN, TNF, CD14, IL8
28
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.6JUN, CREBBP, EP300, IL8
29
Hide members
10.6EP300, CREBBP, TNF, JUN
30
Hide members
10.6JUN, TNF, CREBBP, EP300
31
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
10.6JUN, CREBBP, EP300, RARA
32
Hide members
10.6JUN, CSF2, TNF, IL8
33
Cytokine production by Th17 cells in CF (Mouse model)
10.6CSF2, CD14, IL8
3410.6MPO, TNF, CSF1
3510.6IL8, CD14, JUN
3610.6EP300, CREBBP, JUN
3710.6EP300, CREBBP, JUN
38
Hide members
10.6JUN, CREBBP, EP300
3910.6JUN, CREBBP, EP300
4010.6JUN, CREBBP, EP300
4110.6JUN, CREBBP, EP300
42
Immune response Bacterial infections in normal airways
10.6TNF, CD14, IL8
4310.6TNF, CD14, IL8
4410.6JUN, EP300, IL8
4510.6EP300, CREBBP, TNF
4610.6JUN, TNF, IL8
4710.5EP300, CREBBP
4810.5JUN, CSF2
4910.5CD40
5010.5EP300

Compounds for genes affiliated with Monocytic Leukemia

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4411.4CD14, CD40, CSF2, CRAT, CREBBP, TNF
2retinoic acid44 2412.3RARA, NME1, THBD, EP300, CD14, MPO
3cysteine4411.2IL8, JUN, CSF2, CSF1, CD40, CD14
4pd 98,0594411.2CSF1, JUN, CSF2, CD14, TNF, EP300
5actinomycin d4411.2CD40, CRAT, TNF, CSF1, CSF2, EP300
6calcitriol44 59 11 2414.2THBD, RARA, NME1, EP300, TNF, CSF1
7nitric oxide44 11 2413.2CRAT, MPO, TNF, EP300, IL8, THBD
8serine4411.2JUN, CSF1, RARA, NME1, IL8, EP300
9lactate4411.2CSF2, MPO, CD14, IL8, CSF1, NME1
10retinoid4411.2RARA, JUN, CSF1, CREBBP, CRAT, CD14
11etoposide44 49 59 1114.1CRAT, CSF1, JUN, CSF2, CREBBP, EP300
12neopterin4411.1CSF1, CSF2, TNF, CD40, THBD, IL8
13histamine44 28 2413.1THBD, MPO, CSF2, CSF1, CD40, CD14
14vitamin d4411.1CSF2, CREBBP, CRAT, CD14, EP300, RARA
15pentoxifylline44 1112.1MPO, CSF2, TNF, CRAT, CD14, IL8
16h2o24411.1MPO, CSF2, TNF, THBD, JUN, CRAT
17rantes4411.1JUN, CSF2, CSF1, CREBBP, TNF, CD40
18ly2940024411.1JUN, CSF1, TNF, CD14, EP300, RARA
19creatinine4411.1NME1, THBD, CD14, CSF1, CREBBP, CRAT
20n-formylmethionyl-leucylphenylalanine4411.1TNF, CSF2, CSF1, MPO, IL8, THBD
21dexamethasone44 49 28 1114.1CRAT, RARA, JUN, NME1, CD14
22chloramphenicol44 2 1113.1THBD, CD40, JUN, CSF1, CRAT, MPO
23butyrate4411.1CSF1, CRAT, CD40, CSF2
24thymidine44 2412.0NME1, CD40, CSF2, CSF1, TNF, JUN
25prednisolone44 28 1113.0CD40, MPO, TNF, CSF1, THBD, CD14
26triptolide4411.0JUN, TNF, CD40, CD14, IL8
27n acetylcysteine4411.0TNF, CD40, MPO, IL8, JUN, CSF1
28budesonide44 49 1113.0CSF2, CSF1, TNF, MPO, IL8
29troglitazone44 28 59 1114.0IL8, TNF, JUN, RARA, EP300, CSF1
30fluticasone propionate44 49 59 1114.0IL8, MPO, TNF, CSF1, CSF2
31pge24411.0CSF2, CRAT
32polyinosinic-polycytidylic acid4411.0TNF, CRAT, CD40, CSF1, IL8
33herbimycin a44 5912.0IL8, TNF, CD40, CD14, JUN, CSF2
34il 104411.0IL8, CSF2, TNF, CSF1, CD40
35superoxide44 2411.9TNF, CREBBP, CD40, CSF2
36gm-csf44 2811.9TNF, CD14
37progesterone44 59 28 11 2414.9CRAT, NME1, EP300, RARA, CSF1, THBD
38ionomycin4410.9CD40, EP300, TNF, CSF1, CSF2, JUN
39fmlp4410.9IL8, CSF2, MPO, CSF1, TNF, CD14
40cyclophosphamide44 49 1112.9CD40, THBD, CREBBP, CSF2
4115-deoxy-delta-12,14-prostaglandin j24410.8IL8, JUN, EP300, CSF2, TNF
42paraffin4410.8CD40, RARA, CD14, NME1, THBD, MPO
43ulinastatin4410.8MPO
44cyclosporin a44 28 5912.8IL8, CD14, CD40, JUN, CSF2, TNF
45endotoxin4410.8THBD
46steroid4410.7CREBBP, THBD, RARA, NME1, EP300, CD40
47pdtc4410.7IL8, JUN
48leukotriene b444 59 2412.6CSF2, CSF1, TNF, MPO, IL8
49oligonucleotide4410.6CD40, CRAT, NUP98, THBD, RARA, NME1
50polymyxin b4410.3IL8, THBD, TNF, CD14

GO Terms for genes affiliated with Monocytic Leukemia

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16Gene Ontology
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Cellular components related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7IL8, CD14, MPO, TNF, CSF1, CSF2
2MOZ/MORF histone acetyltransferase complexGO:07077610.2KAT6B, KAT6A

Biological processes related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589310.9RARA, AFF1, CREBBP, TNF, KAT6B, KAT6A
2cellular response to lipopolysaccharideGO:07122210.8CSF2, CD14, IL8, RARA
3inflammatory responseGO:00695410.8CSF1, TNF, CD40, CD14, IL8
4histone acetylationGO:01657310.8CREBBP, KAT6B, KAT6A
5positive regulation of transcription from RNA polymerase II promoterGO:04594410.8RARA, EP300, CD40, MLLT10, TNF, JUN
6N-terminal peptidyl-lysine acetylationGO:01807610.7CREBBP, EP300
7regulation of immunoglobulin secretionGO:05102310.6TNF, CD40
8positive regulation of monocyte differentiationGO:04565710.5JUN, CSF1
9positive regulation by host of viral transcriptionGO:04392310.5EP300, JUN
10positive regulation of podosome assemblyGO:07180310.4TNF, CSF2
11negative regulation of transcription, DNA-dependentGO:04589210.3JUN, KAT6A, KAT6B, TNF, RARA

Molecular functions related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1MLLT10, CREBBP, TNF, CSF2, KAT6B, KAT6A
2acetyltransferase activityGO:01640710.7EP300, CREBBP, KAT6B, KAT6A
3transcription factor bindingGO:00813410.7JUN, KAT6A, KAT6B, CREBBP, EP300, RARA
4RNA polymerase II activating transcription factor bindingGO:00110210.6EP300, CREBBP, JUN
5histone acetyltransferase activityGO:00440210.5EP300, CREBBP, KAT6B, KAT6A
6transcription coactivator activityGO:00371310.3JUN, KAT6A, CREBBP, EP300, RARA

Products for genes affiliated with Monocytic Leukemia

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Sources for Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet