MCID: MNC007
MIFTS: 59

Monocytic Leukemia malady

Cancer diseases category

Summaries for Monocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

MalaCards: Monocytic Leukemia, also known as schilling's leukemia, is related to leukemia and acute monocytic leukemia. An important gene associated with Monocytic Leukemia is KAT6B (K(lysine) acetyltransferase 6B), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Monocytic Leukemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

monocytic leukemia 8 44 60
schilling's leukemia 8


External Ids:

Disease Ontology8 DOID:8527
ICD9CM27 206.8
ICD1025 C93

Related Diseases for Monocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
monocytic leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9AFF1, MPO, MLLT10, CRAT, CREBBP, TNF
2acute monocytic leukemia31.7THBD, RARA, NME1, CD300LF, CD14, CD40
3acute leukemia31.7CSF2, CSF1, CREBBP, MLLT10, MPO, AFF1
4myeloid leukemia30.5CREBBP, CSF1, CSF2, JUN, CRAT, MLLT10
5sarcoma30.5EP300, CSF1
6t-cell leukemia30.4CREBBP, JUN, CRAT, CD40, EP300
7acute lymphocytic leukemia30.3CREBBP, EP300, AFF1, MPO, MLLT10, CSF2
8retinoblastoma30.2NME1, JUN, CREBBP, CRAT, EP300, RARA
9myeloma30.2RARA, CD40, CD14, CSF1, CSF2
10respiratory failure30.2TNF
11hepatocellular carcinoma29.9CRAT, JUN, CD14, NME1, RARA
12neutropenia29.9CSF1, CSF2, CD40, MPO
13letterer-siwe disease29.9RARA, CSF1, CD40
14tuberculosis29.9TNF, CRAT
15obesity29.9RARA, TNF
16multiple myeloma29.9CD40
17neuroblastoma29.9NME1
18sarcoidosis29.9CD14, TNF
19proteinuria29.9MPO, RARA
20leukostasis29.9MPO
21chronic monocytic leukemia10.5
22aleukemic monocytic leukemia cutis10.4
23childhood leukemia10.4
24subacute monocytic leukemia10.4
25acute t cell leukemia10.3
26aleukemic leukemia cutis10.3
27histiocytosis10.3
28testicular leukemia10.3
29acute myeloid leukemia10.3
30subacute leukemia10.2
31central nervous system leukemia10.2
32lymphoblastic leukemia10.2
33myelofibrosis10.2
34mast-cell leukemia10.1
35infectious mononucleosis10.1
36malignant histiocytosis10.1
37gingivitis10.1
38hairy cell leukemia10.1
39lactic acidosis10.1
40melanoma10.0CD14, EP300, IL8, NME1, CRAT, RARA
41ipex syndrome10.0TNF, CD40, CREBBP, EP300, JUN, NUP98
42atherosclerosis10.0JUN, THBD, IL8, CD14, CD40, MPO
43asthma10.0IL8, CD14, MPO, JUN, TNF, CSF1
44acute promyelocytic leukemia10.0JUN, CSF1, EP300, MPO, CREBBP, THBD
45myelodysplastic syndromes10.0CSF2, CSF1, CREBBP, MPO, NUP98, EP300
46hematologic cancer10.0MLLT10, NUP98, CREBBP, RARA, CSF2, CSF1
47osteosarcoma10.0RARA, NME1, EP300, CSF1, JUN, CRAT
48choriocarcinoma10.0JUN, CSF1, CRAT, CREBBP, RARA, CSF2
49alzheimer's disease10.0CD40, JUN, RARA, EP300, CRAT, CREBBP
50rheumatoid arthritis10.0TNF, IL8, JUN, CSF2, CSF1, MPO

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to monocytic leukemia

Clinical Features for Monocytic Leukemia

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Drugs & Therapeutics for Monocytic Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Monocytic Leukemia

Search NIH Clinical Center for Monocytic Leukemia

Search CenterWatch for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

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Anatomical Context for Monocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Monocytic Leukemia:

32
Monocytes, Myeloid, Bone, T cells, Skin, Bone marrow, B cells, Liver, Spinal cord, Nk cells, Endothelial, Testes, Prostate, Lung, Spleen, Pituitary

Animal Models for Monocytic Leukemia or affiliated genes

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36MGI
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Publications for Monocytic Leukemia

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50PubMed
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Articles related to Monocytic Leukemia:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. (23995854)
2013
2
NPM1-mutated acute myeloid leukemia of monocytic or myeloid origin exhibit distinct immunophenotypes. (23601747)
2013
3
Sorting, identification and enrichment of side population cells in THP-1 acute monocytic leukemia cells. (23450319)
2013
4
Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation. (23027709)
2013
5
Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity. (21762960)
2012
6
Jumping translocations of 3q21 in an acute monocytic leukemia (M5) patient reveal mechanisms of multistage telomere shortening in pathogenesis of AML. (21983177)
2012
7
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
8
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. (20138666)
2010
9
Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse. (20066454)
2010
10
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. (20921338)
2010
11
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. (19264921)
2009
12
The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomes. (17689610)
2008
13
Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells. (18418899)
2008
14
Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. (16786142)
2006
15
Comparison of cytogenetics and clinical manifestations between M5a and M5b of acute monocytic leukemia. (16928293)
2006
16
Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). (16105757)
2005
17
Prognosis of acute monocytic leukemia (French-American-British classification M5). (15718341)
2005
18
Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent. (15978937)
2005
19
WT1 gene expression: useful marker for minimal residual disease in childhood myelodysplastic syndromes and juvenile myelo-monocytic leukemia? (15182334)
2004
20
Monocytes in children with leukemias and lymphomas -- down-regulation of HLA and costimulatory molecules. (15625579)
2004
21
Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system. (14978698)
2004
22
Cyanidin and Malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G(2)/M phase and induction of apoptosis. (15080622)
2004
23
A phylogenetic comparison between acute monocytic leukemia cells and monocytes-macrophages in lower vertebrates. (12675202)
2003
24
Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia. (11604555)
2001
25
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. (10022809)
1999
26
Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. (9858570)
1999
27
Jumping translocations involving chromosome 1q in a patient with Crohn disease and acute monocytic leukemia: a review of the literature on jumping translocations in hematological malignancies and Crohn disease. (10087950)
1999
28
"Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia. (1993304)
1991
29
Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia. (2129119)
1990
30
A case of Turner syndrome with the karyotype of 45,X/46,X,i(Xq) associated with acute monocytic leukemia. (2396252)
1990
31
Regulation of interleukin-1 beta and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1. (2801310)
1989
32
Augmentation of human cytotoxic T lymphocytes against autologous tumor by a factor released from human monocytic leukemia cell line. (2503475)
1989
33
Primary fibrinolysis in acute monocytic leukemia. (2767988)
1989
34
A case of aleukemic monocytic leukemia cutis treated with total body electron therapy. (3148160)
1988
35
Intracytoplasmatic and intranuclear filamentous inclusions in a case of acute monocytic leukemia. (3096841)
1986
36
Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. (3855620)
1985
37
Thymidine kinase isoenzymes in human acute monocytic leukemia. (3856734)
1985
38
Monocytic leukemia in a greater bushbaby (Galago crassicaudatus argentatus). (6596461)
1984
39
Clinical and biological aspects of acute monocytic leukemia (a retrospective study of 29 patients). (6815014)
1982
40
Acute monocytic leukemia diagnosed in a patient referred because of gingival pain. (6947009)
1981
41
Masquerading mononucleosis or monocytic leukemia? (6941049)
1981
42
Monocytic leukemia. Clinically appearing as 'malignant reticulosis of the skin'. (272862)
1978
43
The distinctive features of acute monocytic leukemia. (274906)
1978
44
Oral manifestations of acute monocytic leukemia treated with 6-mercaptopurine. (5230988)
1967
45
An extra small acrocentric chromosome in a case of acute monocytic leukemia. (5213033)
1965
46
Leukopenic infectious monocytosis. Report of a case closely simulating acute monocytic leukemia. (13984381)
1963
47
Orbital reticulum-cell sarcoma with monocytic leukemia. Report of two cases. (14476366)
1962
48
Chemotherapeutic management of monocytic leukemia. (13627138)
1958
49
Herpes zoster associated with monocytic leukemia. (18871393)
1948
50
The oral lesions of monocytic leukemia; report of a case. (20987514)
1946

Genetic Variations for Monocytic Leukemia

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Expression for genes affiliated with Monocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monocytic Leukemia

Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for genes affiliated with Monocytic Leukemia

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7CSF2, TNF, CREBBP, EP300, IL8, CSF1
2
Hide members
10.7CSF1, RARA, EP300, CD14, CD40, CREBBP
3
Hide members
10.7CD14, TNF, IL8, EP300, CD40, JUN
4
Hide members
10.7CD40, CD14, NUP98, CREBBP, CSF2, JUN
510.7RARA, CD14, CSF2, MPO, AFF1, CD40
610.7JUN, CSF2, TNF, CREBBP, EP300, CD40
7
Hide members
10.7IL8, TNF, CREBBP, EP300, CD14, JUN
8
Hide members
10.7TNF, JUN, CREBBP, CSF2, IL8, CSF1
910.7TNF, EP300, CREBBP, RARA, JUN, NME1
10
Hide members
10.7JUN, TNF, NUP98, IL8, CREBBP, EP300
11
Hide members
10.6CD14, CREBBP, TNF, JUN, EP300
12
Hide members
10.6TNF, IL8, JUN, EP300, CD14
1310.6JUN, CSF2, CREBBP, IL8, EP300
1410.6TNF, EP300, CREBBP, JUN, IL8
15
Hide members
10.6IL8, JUN, EP300, CREBBP, TNF
1610.6RARA, IL8, EP300, JUN, CREBBP
1710.6CD14, TNF, CSF1, CSF2
1810.6CD40, CREBBP, EP300, JUN
1910.6JUN, CREBBP, CD40, EP300
2010.6TNF, CD14, EP300, CREBBP
2110.6CD40, CD14, TNF, IL8
2210.6IL8, JUN, EP300, THBD
2310.6CD14, JUN, IL8, CSF2
2410.6JUN, CSF2, CREBBP, EP300
2510.6CSF1, JUN, CSF2, TNF
2610.6TNF, IL8, CD14, CSF2
2710.6JUN, TNF, IL8, CD14
28
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.6EP300, IL8, CREBBP, JUN
29
Hide members
10.6CREBBP, TNF, JUN, EP300
30
Hide members
10.6CREBBP, EP300, TNF, JUN
31
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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10.6EP300, CREBBP, JUN, RARA
32
Hide members
10.6JUN, TNF, CSF2, IL8
33
Cytokine production by Th17 cells in CF (Mouse model)
10.6CSF2, CD14, IL8
3410.6MPO, CSF1, TNF
3510.6IL8, CD14, JUN
3610.6EP300, JUN, CREBBP
37
Hide members
10.6EP300, JUN, CREBBP
3810.6CREBBP, EP300, JUN
3910.6EP300, CREBBP, JUN
4010.6EP300, CREBBP, JUN
4110.6EP300, CREBBP, JUN
42
Immune response Bacterial infections in normal airways
10.6IL8, CD14, TNF
4310.6IL8, CD14, TNF
4410.6EP300, JUN, IL8
4510.6CREBBP, TNF, EP300
4610.6JUN, IL8, TNF
4710.5CREBBP, EP300
4810.5CSF2, JUN
4910.5CD40
5010.5EP300

Compounds for genes affiliated with Monocytic Leukemia

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4411.4CD14, CD40, CSF2, CRAT, CREBBP, TNF
2retinoic acid44 2412.3RARA, NME1, THBD, EP300, CD14, MPO
3cysteine4411.2IL8, JUN, CSF2, CSF1, CD40, CD14
4pd 98,0594411.2CSF1, JUN, CSF2, CD14, TNF, EP300
5actinomycin d4411.2CD40, CRAT, TNF, CSF1, CSF2, EP300
6calcitriol44 59 11 2414.2THBD, RARA, NME1, EP300, TNF, CSF1
7nitric oxide44 11 2413.2CRAT, MPO, TNF, EP300, IL8, THBD
8serine4411.2JUN, CSF1, RARA, NME1, IL8, EP300
9lactate4411.2CSF2, MPO, CD14, IL8, CSF1, NME1
10retinoid4411.2RARA, JUN, CSF1, CREBBP, CRAT, CD14
11etoposide44 49 59 1114.1CRAT, CSF1, JUN, CSF2, CREBBP, EP300
12neopterin4411.1CSF1, CSF2, TNF, CD40, THBD, IL8
13histamine44 28 2413.1THBD, MPO, CSF2, CSF1, CD40, CD14
14vitamin d4411.1CSF2, CREBBP, CRAT, CD14, EP300, RARA
15pentoxifylline44 1112.1MPO, CSF2, TNF, CRAT, CD14, IL8
16h2o24411.1MPO, CSF2, TNF, THBD, JUN, CRAT
17rantes4411.1JUN, CSF2, CSF1, CREBBP, TNF, CD40
18ly2940024411.1JUN, CSF1, TNF, CD14, EP300, RARA
19creatinine4411.1NME1, THBD, CD14, CSF1, CREBBP, CRAT
20n-formylmethionyl-leucylphenylalanine4411.1TNF, CSF2, CSF1, MPO, IL8, THBD
21dexamethasone44 49 28 1114.1CRAT, RARA, JUN, NME1, CD14
22chloramphenicol44 2 1113.1THBD, CD40, JUN, CSF1, CRAT, MPO
23butyrate4411.1CSF1, CRAT, CD40, CSF2
24thymidine44 2412.0NME1, CD40, CSF2, CSF1, TNF, JUN
25prednisolone44 28 1113.0CD40, MPO, TNF, CSF1, THBD, CD14
26triptolide4411.0JUN, TNF, CD40, CD14, IL8
27n acetylcysteine4411.0TNF, CD40, MPO, IL8, JUN, CSF1
28budesonide44 49 1113.0CSF2, CSF1, TNF, MPO, IL8
29troglitazone44 28 59 1114.0IL8, TNF, JUN, RARA, EP300, CSF1
30fluticasone propionate44 49 59 1114.0IL8, MPO, TNF, CSF1, CSF2
31pge24411.0CSF2, CRAT
32polyinosinic-polycytidylic acid4411.0TNF, CRAT, CD40, CSF1, IL8
33herbimycin a44 5912.0IL8, TNF, CD40, CD14, JUN, CSF2
34il 104411.0IL8, CSF2, TNF, CSF1, CD40
35superoxide44 2411.9TNF, CREBBP, CD40, CSF2
36gm-csf44 2811.9TNF, CD14
37progesterone44 59 28 11 2414.9CRAT, NME1, EP300, RARA, CSF1, THBD
38ionomycin4410.9CD40, EP300, TNF, CSF1, CSF2, JUN
39fmlp4410.9IL8, CSF2, MPO, CSF1, TNF, CD14
40cyclophosphamide44 49 1112.9CD40, THBD, CREBBP, CSF2
4115-deoxy-delta-12,14-prostaglandin j24410.8IL8, JUN, EP300, CSF2, TNF
42paraffin4410.8CD40, RARA, CD14, NME1, THBD, MPO
43ulinastatin4410.8MPO
44cyclosporin a44 28 5912.8IL8, CD14, CD40, JUN, CSF2, TNF
45endotoxin4410.8THBD
46steroid4410.7CREBBP, THBD, RARA, NME1, EP300, CD40
47pdtc4410.7IL8, JUN
48leukotriene b444 59 2412.6CSF2, CSF1, TNF, MPO, IL8
49oligonucleotide4410.6CD40, CRAT, NUP98, THBD, RARA, NME1
50polymyxin b4410.3IL8, THBD, TNF, CD14

GO Terms for genes affiliated with Monocytic Leukemia

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16Gene Ontology
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Cellular components related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7IL8, CD14, MPO, TNF, CSF1, CSF2
2MOZ/MORF histone acetyltransferase complexGO:07077610.2KAT6B, KAT6A

Biological processes related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589310.9RARA, AFF1, CREBBP, TNF, KAT6B, KAT6A
2cellular response to lipopolysaccharideGO:07122210.8CSF2, CD14, IL8, RARA
3inflammatory responseGO:00695410.8CSF1, TNF, CD40, CD14, IL8
4histone acetylationGO:01657310.8CREBBP, KAT6B, KAT6A
5positive regulation of transcription from RNA polymerase II promoterGO:04594410.8RARA, EP300, CD40, MLLT10, TNF, JUN
6N-terminal peptidyl-lysine acetylationGO:01807610.7CREBBP, EP300
7regulation of immunoglobulin secretionGO:05102310.6TNF, CD40
8positive regulation of monocyte differentiationGO:04565710.5JUN, CSF1
9positive regulation by host of viral transcriptionGO:04392310.5EP300, JUN
10positive regulation of podosome assemblyGO:07180310.4TNF, CSF2
11negative regulation of transcription, DNA-dependentGO:04589210.3JUN, KAT6A, KAT6B, TNF, RARA

Molecular functions related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1MLLT10, CREBBP, TNF, CSF2, KAT6B, KAT6A
2acetyltransferase activityGO:01640710.7EP300, CREBBP, KAT6B, KAT6A
3transcription factor bindingGO:00813410.7JUN, KAT6A, KAT6B, CREBBP, EP300, RARA
4RNA polymerase II activating transcription factor bindingGO:00110210.6EP300, CREBBP, JUN
5histone acetyltransferase activityGO:00440210.5EP300, CREBBP, KAT6B, KAT6A
6transcription coactivator activityGO:00371310.3JUN, KAT6A, CREBBP, EP300, RARA

Products for genes affiliated with Monocytic Leukemia

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  • Antibodies
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Sources for Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet