MCID: MNC007
MIFTS: 49

Monocytic Leukemia malady

Cancer diseases category

Summaries for Monocytic Leukemia

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Wikipedia:63 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

MalaCards based summary: Monocytic Leukemia, also known as m5b acute differentiated monocytic leukemia, is related to sarcoma and acute monocytic leukemia. An important gene associated with Monocytic Leukemia is KAT6B (K(lysine) acetyltransferase 6B), and among its related pathways are Hematopoietic cell lineage and NF-kappa B signaling pathway. The compounds gm-csf and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are other and adipose tissue.

Aliases & Classifications for Monocytic Leukemia

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 25ICD10
See all sources

Monocytic Leukemia, Aliases & Descriptions:

Name: Monocytic Leukemia 9 43 60
M5b Acute Differentiated Monocytic Leukemia 60
 
Schilling's Leukemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:8527
ICD9CM27 206.8
ICD1025 C93

Related Diseases for Monocytic Leukemia

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Diseases in the Monocytic Leukemia family:

Acute Monocytic Leukemia Chronic Monocytic Leukemia
Subacute Monocytic Leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.0CSF1, EP300
2acute monocytic leukemia30.8CD40, EP300, CD14, NME1, CREBBP, CSF1
3langerhans-cell histiocytosis30.6CD40, CSF1
4chronic myelomonocytic leukemia30.4CSF2, CSF1, MPO
5refractory anemia30.4CSF2, CSF1
6myeloma30.3CD14, CSF2, CSF1, CD40
7leukemia30.2JUN, KAT6B, MPO, EP300, CSF2, CSF1
8acute pancreatitis30.2CD14, IL8, MPO
9acute myelomonocytic leukemia30.1MPO, CREBBP, CSF1
10neutropenia30.0CSF2, MPO, CD40, CSF1
11myelodysplastic syndrome29.9MPO, EP300, CSF2, CSF1, CREBBP
12retinoblastoma29.8JUN, EP300, CREBBP, NME1
13t-cell leukemia29.6CREBBP, CD40, EP300, JUN
14leukemia, acute lymphoblastic29.5MPO, JUN, EP300, CSF2, CREBBP, CD40
15myeloid leukemia29.0MPO, JUN, CSF1, CD14, CSF2, CREBBP
16chronic monocytic leukemia10.5
17aleukemic monocytic leukemia cutis10.4
18peripheral vascular disease10.4MPO
19polyarteritis nodosa10.4MPO
20felty's syndrome10.4CSF2
21capillary leak syndrome10.4CSF2
22subacute monocytic leukemia10.4
23periodontitis10.4IL8
24histiocytosis10.4
25lung cancer10.4CSF2
26churg-strauss syndrome10.3THBD, MPO
27neutropenia, cyclic10.3CSF2, CSF1
28extrinsic allergic alveolitis10.3CD14, IL8
29skin disease10.3MPO
30pulmonary alveolar proteinosis10.3CSF2, CSF1
31arteriosclerosis10.3CD40, CD14
32pancytopenia10.3CSF2, CSF1
33peptic ulcer disease10.3CD14, IL8
34myelofibrosis10.3
35lymphoblastic leukemia10.3
36acute respiratory distress syndrome10.3THBD, IL8
37lupus nephritis10.2CSF1, CD40, THBD
38acute myocardial infarction10.2CD14, CD40, THBD
39granulocytopenia10.2CSF2, MPO
40rubinstein-taybi syndrome10.2EP300, CREBBP
41allergic rhinitis10.2IL8, MPO
42megakaryocytic leukemia10.2MPO, CSF2
43wegener granulomatosis10.2MPO, CD14
44bronchiectasis10.2IL8, MPO
45vasculitis10.2CD14, MPO, THBD
46connective tissue disease10.2THBD, MPO, CD40
47chronic granulomatous disease10.2CSF2, MPO
48aleukemic leukemia cutis10.2
49gingivitis10.2
50lactic acidosis10.2

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to monocytic leukemia

Symptoms for Monocytic Leukemia

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Drugs & Therapeutics for Monocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Monocytic Leukemia

Search NIH Clinical Center for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

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Anatomical Context for Monocytic Leukemia

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MalaCards organs/tissues related to Monocytic Leukemia:

31
Monocytes, Myeloid, Bone, Bone marrow, Skin, T cells, Spinal cord, Liver, B cells, Spleen, Lung, Prostate, Testes, Pituitary

Animal Models for Monocytic Leukemia or affiliated genes

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Publications for Monocytic Leukemia

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Articles related to Monocytic Leukemia:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
Alkaline phosphatase is a useful cytochemical marker for the diagnosis of acute myelomonocytic and monocytic leukemia in the dog. (25546124)
2015
2
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. (23995854)
2013
3
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
4
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
5
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
6
Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. (21779573)
2011
7
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
8
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. (19264921)
2009
9
Significance of transmission electron microscopy in subtyping of monocytic leukemia. (19274583)
2009
10
A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)
2008
11
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
12
Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. (19330074)
2008
13
Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. (18928586)
2008
14
Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. (16786142)
2006
15
Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY. (15964069)
2005
16
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
17
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
18
A novel therapeutic strategy against monocytic leukemia with deoxyadenosine analogs and adenosine deaminase inhibitors. (11697650)
2001
19
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
20
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
21
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
22
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. (10497217)
1999
23
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. (10022809)
1999
24
Transient expression of M-CSF is important for osteoclast-like cell differentiation in a monocytic leukemia cell line. (9015756)
1997
25
Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia]. (10743082)
1997
26
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. (8667638)
1996
27
Tetrasomy 8 and t(1;11)(p32;q24) in acute myelo-monocytic leukemia with extensive leukemic cutaneous involvement. (8833413)
1996
28
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia. (8721686)
1996
29
Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia. (8535230)
1995
30
Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line. (8412297)
1993
31
Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937. (8389212)
1993
32
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
33
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
34
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. (1531307)
1992
35
Induction of interdigitating reticulum cell-like differentiation in human monocytic leukemia cells by conditioned medium from IL-2-stimulated helper T-cells. (1355319)
1992
36
Letterer-Siwe disease and subacute monocytic leukemia. (2808842)
1989
37
Phenotyping of acute myelomonocytic (AMMOL) and monocytic leukemia (AMOL): association of T-cell-related antigens and skin-infiltration in AMOL. (2685474)
1989
38
Establishment of an etoposide (VP-16)-resistant subline of THP-1 human monocytic leukemia cell line. (2727988)
1989
39
Regulation of interleukin-1 beta and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1. (2801310)
1989
40
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
41
Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. (3855620)
1985
42
Massive metastatic pulmonary calcification in an infant with aleukemic monocytic leukemia. (2423997)
1985
43
Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin. (2989063)
1985
44
Cytochemical, functional, and proliferative characteristics of promonocytes and monocytes from patients with monocytic leukemia. (6223673)
1983
45
Pure acute monocytic leukemia. A study of 12 cases. (304666)
1977
46
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
47
Monocytic leukemia as a cause of acute respiratory obstruction. (4521037)
1974
48
Monocytic leukemia in cattle. I. Cytological observations of two cases. (5234777)
1967
49
Orbital reticulum-cell sarcoma with monocytic leukemia. Report of two cases. (14476366)
1962
50
Acute monocytic leukemia responsive to ACTH therapy. (13002763)
1952

Variations for Monocytic Leukemia

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Expression for genes affiliated with Monocytic Leukemia

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Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for genes affiliated with Monocytic Leukemia

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Pathways related to Monocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD14, CSF1, CSF2
29.3CD40, CD14, IL8
3
Show member pathways
9.1CD14, CSF2, IL8
49.1CD14, CSF2, IL8
59.1EP300, NME1, CREBBP
69.0MPO, CREBBP, EP300
7
Show member pathways
9.0CREBBP, EP300, IL8
8
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.8IL8, CD14, JUN
98.8CD14, IL8, JUN
108.8CSF1, JUN, CSF2
118.8IL8, EP300, JUN
128.8JUN, EP300, IL8
13
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
8.7JUN, EP300, CREBBP
148.7JUN, EP300, CREBBP
158.7JUN, EP300, CREBBP
168.7CREBBP, EP300, JUN
178.7JUN, CREBBP, EP300
188.7JUN, CREBBP, EP300
198.7EP300, CREBBP, JUN
208.7EP300, JUN, CREBBP
21
Show member pathways
8.7JUN, CREBBP, EP300
228.7JUN, CREBBP, EP300
238.7EP300, CREBBP, JUN
24
Show member pathways
8.7EP300, CREBBP, JUN
25
Show member pathways
DNA damage Role of SUMO in p53 regulation58
8.7CREBBP, EP300, JUN
26
Show member pathways
FOXA transcription factor networks36
8.7EP300, CREBBP, JUN
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.6CSF2, IL8, JUN
28
Show member pathways
Immune response MIF in innate immunity response58
8.5EP300, CD14, IL8, JUN
298.4EP300, THBD, IL8, JUN
30
Show member pathways
8.4CD14, CREBBP, EP300, JUN
318.4MPO, CSF2, CD14, CD40, IL8
328.3JUN, CREBBP, CD40, EP300
338.3JUN, EP300, CREBBP, CD40
34
Show member pathways
8.3CSF2, CD14, JUN, IL8
358.3JUN, CSF1, CSF2, IL8
368.2NME1, CREBBP, JUN, EP300
378.1CSF2, EP300, JUN, CREBBP
38
Show member pathways
8.1EP300, JUN, CREBBP, IL8
398.1JUN, IL8, EP300, CREBBP
408.1JUN, EP300, IL8, CREBBP
41
Show member pathways
8.1JUN, EP300, IL8, CREBBP
42
Show member pathways
8.1EP300, JUN, CREBBP, IL8
43
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling58
8.1EP300, IL8, CREBBP, JUN
44
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
7.9JUN, CD14, EP300, IL8, CREBBP
457.8JUN, CREBBP, CD40, EP300, CSF2
46
Show member pathways
7.7JUN, CREBBP, CSF1, IL8, CSF2
477.6CREBBP, CSF2, IL8, EP300, JUN
48
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.5CREBBP, CD40, CD14, IL8, EP300, JUN
49
Show member pathways
7.3EP300, CREBBP, JUN, CSF2, CSF1, IL8
50
Show member pathways
6.7CD14, JUN, EP300, IL8, CSF2, CSF1

Compounds for genes affiliated with Monocytic Leukemia

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Compounds related to Monocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1gm-csf43 2810.2CSF1, CD14, IL8, CSF2
2prednisolone43 28 1211.1CD14, CD40, CSF1, MPO, THBD
3budesonide43 49 1211.0MPO, IL8, CSF2, CSF1
4il 10439.0CD40, CSF1, CSF2, IL8
5fluticasone propionate43 49 59 1212.0MPO, IL8, CSF2, CSF1
6triptolide438.9CD14, CD40, IL8, JUN
7methacholine43 49 1210.8IL8, MPO, CSF2, CD14
8mitoxantrone43 49 1210.8CSF2, MPO, CREBBP, CSF1
9pentoxifylline43 129.8THBD, MPO, IL8, CSF2, CD14
10endotoxin438.8CD40, CD14, CSF2, IL8, THBD
11n-formylmethionyl-leucylphenylalanine438.7THBD, CSF2, IL8, CSF1, MPO
12mannose438.7CSF2, CSF1, CD14, CD40, CREBBP
13paraffin438.7CSF1, MPO, THBD, NME1, CD14, CD40
14fmlp438.6CD14, CSF1, MPO, IL8, CSF2
15dmso438.6THBD, MPO, CSF2, NME1, CSF1
16neopterin438.6THBD, CSF1, CD14, CD40, IL8, CSF2
17ionomycin438.4EP300, CSF2, CSF1, CD40, JUN
18cyclophosphamide43 49 1210.3CSF1, THBD, MPO, CSF2, CREBBP, CD40
19herbimycin a43 599.3CSF2, CD40, CD14, JUN, IL8
20ly294002438.2IL8, JUN, CSF1, CD40, CD14, EP300
21wortmannin438.2CD14, CD40, CSF2, CSF1, JUN, EP300
22histamine43 28 2410.1CSF1, CD40, CSF2, IL8, MPO, THBD
23retinoid438.1EP300, CD14, JUN, THBD, CSF1, CREBBP
24heparin43 28 24 1211.1CSF2, CSF1, MPO, THBD, CD14, IL8
255fluorouracil438.1CREBBP, MPO, CSF2, CSF1, NME1
26lactate438.0THBD, MPO, IL8, CSF2, CSF1, CD14
27cyclosporin a43 28 599.9THBD, JUN, IL8, CSF2, CD40, CD14
28cisplatin43 49 59 1210.9CSF1, CREBBP, CSF2, NME1, EP300, MPO
29chloramphenicol43 2 49 1210.9CD40, CSF1, JUN, MPO, THBD
30vitamin d437.9EP300, CREBBP, JUN, THBD, CD14, CSF2
31calcitriol43 59 24 1210.9THBD, JUN, EP300, CSF1, NME1, CD14
32superoxide43 248.8CD14, MPO, CSF2, CSF1, CREBBP, CD40
33etoposide43 49 59 1210.8CSF1, NME1, CREBBP, CSF2, EP300, JUN
34creatinine437.8CREBBP, THBD, MPO, EP300, CSF1, NME1
35cycloheximide437.8CSF2, CSF1, IL8, CD14, JUN, THBD
36nitric oxide43 24 129.7CREBBP, IL8, EP300, MPO, THBD, CD40
37actinomycin d437.7CSF2, THBD, JUN, EP300, IL8, CSF1
38h2o2437.6IL8, CD40, CSF1, JUN, MPO, THBD
39phosphatidylinositol437.6CSF2, CSF1, CD40, EP300, JUN, CD14
40rantes437.5CSF1, CREBBP, IL8, JUN, CSF2, CD40
41dexamethasone43 49 28 1210.4IL8, THBD, JUN, CSF2, CD40, NME1
42pd 98,059437.1CREBBP, CD40, CD14, CSF2, IL8, EP300
43estrogen437.1THBD, JUN, NME1, CREBBP, CSF1, CSF2
44tyrosine436.8CSF1, THBD, NME1, CREBBP, CSF2, EP300
45butyrate436.7IL8, EP300, JUN, MPO, CD40, CD14
46retinoic acid43 247.5THBD, MPO, CSF2, CSF1, CREBBP, NME1
47serine436.4THBD, CREBBP, CSF1, IL8, EP300, CD14
48cysteine436.4JUN, EP300, IL8, CSF2, CSF1, CREBBP
49pge2436.3JUN, EP300, IL8, CREBBP, CSF2, CSF1
50vegf435.9IL8, THBD, MPO, JUN, CD40, CD14

GO Terms for genes affiliated with Monocytic Leukemia

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Cellular components related to Monocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:00001239.2CREBBP, EP300
2transcription factor complexGO:00056678.7CREBBP, EP300, JUN
3extracellular spaceGO:00056157.6IL8, THBD, CD40, CD14, CSF1, CSF2

Biological processes related to Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:00107449.8CSF1, CSF2
2N-terminal peptidyl-lysine acetylationGO:00180769.7CREBBP, EP300
3response to tumor necrosis factorGO:00346129.7CD14, EP300
4positive regulation of DNA bindingGO:00433889.7NME1, EP300
5histone acetylationGO:00165739.7KAT6B, CREBBP
6positive regulation of monocyte differentiationGO:00456579.6CSF1, JUN
7positive regulation by host of viral transcriptionGO:00439239.5EP300, JUN
8chromatin organizationGO:00063259.4KAT6B, EP300, CREBBP
9inflammatory responseGO:00069549.3CD40, CD14, CSF1, IL8
10regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.2CREBBP, EP300
11response to cAMPGO:00515919.2THBD, JUN, NME1
12positive regulation of DNA replicationGO:00457409.1CSF2, JUN
13cellular response to lipopolysaccharideGO:00712229.1CD40, CD14, CSF2, IL8
14response to lipopolysaccharideGO:00324969.0JUN, MPO, THBD
15innate immune responseGO:00450878.3JUN, EP300, CSF1, CREBBP, CD14

Molecular functions related to Monocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:00164079.3CREBBP, EP300, KAT6B
2histone acetyltransferase activityGO:00044029.1KAT6B, EP300, CREBBP
3RNA polymerase II activating transcription factor bindingGO:00011028.7JUN, EP300, CREBBP
4transcription coactivator activityGO:00037138.7CREBBP, EP300, JUN
5transcription factor bindingGO:00081348.1CREBBP, EP300, JUN, KAT6B
6protein bindingGO:00055156.0THBD, KAT6B, JUN, EP300, IL8, CSF2

Products for genes affiliated with Monocytic Leukemia

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Sources for Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet