MCID: MNC007
MIFTS: 58

Monocytic Leukemia malady

Cancer diseases, Rare diseases, Blood diseases categories
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Summaries for Monocytic Leukemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

MalaCards: Monocytic Leukemia, also known as schilling's leukemia, is related to leukemia and acute monocytic leukemia. An important gene associated with Monocytic Leukemia is KAT6B (K(lysine) acetyltransferase 6B), and among its related pathways are Hematopoietic cell lineage and NF-kappa B signaling pathway. The compounds gm-csf and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are other and adipose tissue.

Aliases & Classifications for Monocytic Leukemia

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

monocytic leukemia 8 45 62
schilling's leukemia 8


External Ids:

Disease Ontology8 DOID:8527
ICD9CM27 206.8
ICD1025 C93

Related Diseases for Monocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
monocytic leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.6KAT6B, MPO, JUN, EP300, CSF2, CSF1
2acute monocytic leukemia31.5THBD, MPO, EP300, CSF1, CREBBP, NME1
3histiocytosis30.7CD40, CSF1
4sarcoma30.6CSF1, EP300
5chronic myelomonocytic leukemia30.3CSF1, CSF2, MPO
6myeloma30.2CD40, CD14, CSF1, CSF2
7myelodysplastic syndromes30.1MPO, EP300, CSF2, CSF1, CREBBP
8retinoblastoma30.1JUN, EP300, CREBBP, NME1
9refractory anemia30.1CSF1, CSF2
10myeloid leukemia30.1MPO, JUN, CSF2, CSF1, CREBBP, NME1
11non-hodgkin lymphoma30.0CSF2, CD14, CD40
12acute myelomonocytic leukemia30.0CREBBP, CSF1, MPO
13neutropenia30.0CD40, CSF1, CSF2, MPO
14t-cell leukemia29.9CD40, CREBBP, EP300, JUN
15acute lymphocytic leukemia29.8MPO, JUN, EP300, CSF2, CREBBP, CD40
16chronic monocytic leukemia10.5
17aleukemic monocytic leukemia cutis10.4
18subacute monocytic leukemia10.3
19lymphoblastic leukemia10.2
20myelofibrosis10.2
21infectious mononucleosis10.2
22acute myeloid leukemia10.2
23aleukemic leukemia cutis10.2
24gingivitis10.2
25lactic acidosis10.2
26respiratory failure10.2
27cytomegalovirus infection10.2
28germ cell tumors10.2
29peripheral vascular disease10.1MPO
30polyarteritis nodosa10.1MPO
31felty's syndrome10.1CSF2
32capillary leak syndrome10.1CSF2
33periodontitis10.1IL8
34lung cancer10.1CSF2
35churg-strauss syndrome10.1THBD, MPO
36cyclic hematopoiesis10.1CSF1, CSF2
37extrinsic allergic alveolitis10.1CD14, IL8
38skin disease10.1MPO
39arteriosclerosis10.1CD14, CD40
40pulmonary alveolar proteinosis10.1CSF1, CSF2
41stroke, ischemic10.1CSF1, THBD
42pancytopenia10.1CSF1, CSF2
43peptic ulcer disease10.1CD14, IL8
44adult respiratory distress syndrome10.1THBD, IL8
45lupus nephritis10.1CD40, CSF1, THBD
46acute myocardial infarction10.1CD40, CD14, THBD
47rubinstein-taybi syndrome10.1EP300, CREBBP
48allergic rhinitis10.0MPO, IL8
49megakaryocytic leukemia10.0CSF2, MPO
50wegener's granulomatosis10.0CD14, MPO

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to monocytic leukemia

Symptoms for Monocytic Leukemia

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Drugs & Therapeutics for Monocytic Leukemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Monocytic Leukemia

Search NIH Clinical Center for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

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Anatomical Context for Monocytic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Monocytic Leukemia:

33
Monocytes, Myeloid, Bone, Bone marrow, Skin, T cells, B cells, Spinal cord, Liver, Testes, Prostate, Lung, Spleen, Pituitary

Animal Models for Monocytic Leukemia or affiliated genes

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37MGI
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Publications for Monocytic Leukemia

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52PubMed
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Articles related to Monocytic Leukemia:

(show top 50)    (show all 476)
idTitleAuthorsYear
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. (23995854)
2013
2
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
3
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
4
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
5
Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. (21779573)
2011
6
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
7
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. (19264921)
2009
8
Significance of transmission electron microscopy in subtyping of monocytic leukemia. (19274583)
2009
9
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
10
Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. (19330074)
2008
11
Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. (18928586)
2008
12
Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. (16786142)
2006
13
Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY. (15964069)
2005
14
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
15
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
16
A novel therapeutic strategy against monocytic leukemia with deoxyadenosine analogs and adenosine deaminase inhibitors. (11697650)
2001
17
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
18
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
19
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
20
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. (10497217)
1999
21
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. (10022809)
1999
22
Transient expression of M-CSF is important for osteoclast-like cell differentiation in a monocytic leukemia cell line. (9015756)
1997
23
Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia]. (10743082)
1997
24
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. (8667638)
1996
25
Tetrasomy 8 and t(1;11)(p32;q24) in acute myelo-monocytic leukemia with extensive leukemic cutaneous involvement. (8833413)
1996
26
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia. (8721686)
1996
27
Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia. (8535230)
1995
28
Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line. (8412297)
1993
29
Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937. (8389212)
1993
30
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
31
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
32
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. (1531307)
1992
33
Induction of interdigitating reticulum cell-like differentiation in human monocytic leukemia cells by conditioned medium from IL-2-stimulated helper T-cells. (1355319)
1992
34
Synthesis of active metabolite(s) from 1 alpha-hydroxyvitamin D3 by human monocytic leukemia cells. (1516717)
1992
35
Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia. (2129119)
1990
36
Letterer-Siwe disease and subacute monocytic leukemia. (2808842)
1989
37
Phenotyping of acute myelomonocytic (AMMOL) and monocytic leukemia (AMOL): association of T-cell-related antigens and skin-infiltration in AMOL. (2685474)
1989
38
Establishment of an etoposide (VP-16)-resistant subline of THP-1 human monocytic leukemia cell line. (2727988)
1989
39
Regulation of interleukin-1 beta and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1. (2801310)
1989
40
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
41
Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. (3855620)
1985
42
Massive metastatic pulmonary calcification in an infant with aleukemic monocytic leukemia. (2423997)
1985
43
Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin. (2989063)
1985
44
Cytochemical, functional, and proliferative characteristics of promonocytes and monocytes from patients with monocytic leukemia. (6223673)
1983
45
Pure acute monocytic leukemia. A study of 12 cases. (304666)
1977
46
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
47
Monocytic leukemia as a cause of acute respiratory obstruction. (4521037)
1974
48
Monocytic leukemia in cattle. I. Cytological observations of two cases. (5234777)
1967
49
Orbital reticulum-cell sarcoma with monocytic leukemia. Report of two cases. (14476366)
1962
50
Acute monocytic leukemia responsive to ACTH therapy. (13002763)
1952

Variations for Monocytic Leukemia

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Expression for genes affiliated with Monocytic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monocytic Leukemia

Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for genes affiliated with Monocytic Leukemia

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems
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Pathways related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CSF2, CSF1, CD14
29.3CD40, CD14, IL8
39.1IL8, CSF2, CD14
4
Show member pathways
9.1IL8, CSF2, CD14
59.1EP300, CREBBP, NME1
69.0MPO, EP300, CREBBP
7
Show member pathways
9.0CREBBP, IL8, EP300
88.8CD14, IL8, JUN
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.8JUN, IL8, CD14
108.8CSF1, CSF2, JUN
118.8JUN, EP300, IL8
128.8JUN, EP300, IL8
138.7JUN, EP300, CREBBP
148.7JUN, EP300, CREBBP
158.7JUN, EP300, CREBBP
16
Show member pathways
DNA damage Role of SUMO in p53 regulation60
8.7JUN, EP300, CREBBP
17
Show member pathways
8.7JUN, EP300, CREBBP
188.7JUN, EP300, CREBBP
19
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
8.7JUN, EP300, CREBBP
208.7CREBBP, EP300, JUN
218.7CREBBP, EP300, JUN
228.7CREBBP, EP300, JUN
238.7CREBBP, EP300, JUN
24
Show member pathways
FOXA transcription factor networks38
8.7CREBBP, EP300, JUN
25
Show member pathways
8.7CREBBP, EP300, JUN
268.7CREBBP, EP300, JUN
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.6JUN, IL8, CSF2
28
Show member pathways
Immune response MIF in innate immunity response60
8.5JUN, EP300, IL8, CD14
298.4IL8, EP300, JUN, THBD
30
Show member pathways
8.4CD14, CREBBP, EP300, JUN
318.4MPO, IL8, CSF2, CD14, CD40
328.3JUN, EP300, CREBBP, CD40
338.3JUN, EP300, CREBBP, CD40
34
Show member pathways
8.3JUN, IL8, CSF2, CD14
358.3JUN, IL8, CSF2, CSF1
368.2JUN, EP300, CREBBP, NME1
378.1JUN, EP300, CSF2, CREBBP
38
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
8.1CREBBP, IL8, EP300, JUN
398.1JUN, EP300, IL8, CREBBP
40
Show member pathways
8.1JUN, EP300, IL8, CREBBP
418.1JUN, EP300, IL8, CREBBP
42
Show member pathways
8.1CREBBP, IL8, EP300, JUN
43
Show member pathways
8.1JUN, EP300, IL8, CREBBP
44
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.9JUN, EP300, IL8, CREBBP, CD14
457.8CD40, CREBBP, CSF2, EP300, JUN
46
Show member pathways
7.7JUN, IL8, CSF2, CSF1, CREBBP
477.6JUN, EP300, IL8, CSF2, CREBBP
48
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
7.5JUN, EP300, IL8, CREBBP, CD14, CD40
49
Show member pathways
7.3JUN, EP300, IL8, CSF2, CSF1, CREBBP
50
Show member pathways
6.7CD40, JUN, EP300, IL8, CSF2, CSF1

Compounds for genes affiliated with Monocytic Leukemia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2910.2CSF1, CD14, IL8, CSF2
2prednisolone45 29 1111.1CD14, CD40, CSF1, MPO, THBD
3budesonide45 51 1111.0MPO, IL8, CSF2, CSF1
4il 10459.0CD40, CSF1, CSF2, IL8
5fluticasone propionate45 51 61 1112.0MPO, IL8, CSF2, CSF1
6triptolide458.9CD14, CD40, IL8, JUN
7methacholine45 51 1110.8IL8, MPO, CSF2, CD14
8mitoxantrone45 51 1110.8CSF2, MPO, CREBBP, CSF1
9pentoxifylline45 119.8THBD, MPO, IL8, CSF2, CD14
10endotoxin458.8CD40, CD14, CSF2, IL8, THBD
11n-formylmethionyl-leucylphenylalanine458.7THBD, CSF2, IL8, CSF1, MPO
12mannose458.7CSF2, CSF1, CD14, CD40, CREBBP
13paraffin458.7CSF1, MPO, THBD, NME1, CD14, CD40
14fmlp458.6CD14, CSF1, MPO, IL8, CSF2
15dmso458.6THBD, MPO, CSF2, NME1, CSF1
16neopterin458.6THBD, CSF1, CD14, CD40, IL8, CSF2
17ionomycin458.4EP300, CSF2, CSF1, CD40, JUN
18cyclophosphamide45 51 1110.3CSF1, THBD, MPO, CSF2, CREBBP, CD40
19herbimycin a45 619.3CSF2, CD40, CD14, JUN, IL8
20ly294002458.2IL8, JUN, CSF1, CD40, CD14, EP300
21wortmannin458.2CD14, CD40, CSF2, CSF1, JUN, EP300
22histamine45 29 2410.1CSF1, CD40, CSF2, IL8, MPO, THBD
23retinoid458.1EP300, CD14, JUN, THBD, CSF1, CREBBP
24heparin45 29 24 1111.1CSF2, CSF1, MPO, THBD, CD14, IL8
255fluorouracil458.1CREBBP, MPO, CSF2, CSF1, NME1
26lactate458.0THBD, MPO, IL8, CSF2, CSF1, CD14
27cyclosporin a45 29 619.9THBD, JUN, IL8, CSF2, CD40, CD14
28cisplatin45 51 61 1110.9CSF1, CREBBP, CSF2, NME1, EP300, MPO
29chloramphenicol45 3 51 1110.9CD40, CSF1, JUN, MPO, THBD
30vitamin d457.9EP300, CREBBP, JUN, THBD, CD14, CSF2
31calcitriol45 61 24 1110.9THBD, JUN, EP300, CSF1, NME1, CD14
32superoxide45 248.8CD14, MPO, CSF2, CSF1, CREBBP, CD40
33etoposide45 51 61 1110.8CSF1, NME1, CREBBP, CSF2, EP300, JUN
34creatinine457.8CREBBP, THBD, MPO, EP300, CSF1, NME1
35cycloheximide457.8CSF2, CSF1, IL8, CD14, JUN, THBD
36nitric oxide45 24 119.7CREBBP, IL8, EP300, MPO, THBD, CD40
37actinomycin d457.7CSF2, THBD, JUN, EP300, IL8, CSF1
38h2o2457.6IL8, CD40, CSF1, JUN, MPO, THBD
39phosphatidylinositol457.6CSF2, CSF1, CD40, EP300, JUN, CD14
40rantes457.5CSF1, CREBBP, IL8, JUN, CSF2, CD40
41dexamethasone45 51 29 1110.4IL8, THBD, JUN, CSF2, CD40, NME1
42pd 98,059457.1CREBBP, CD40, CD14, CSF2, IL8, EP300
43estrogen457.1THBD, JUN, NME1, CREBBP, CSF1, CSF2
44tyrosine456.8CSF1, THBD, NME1, CREBBP, CSF2, EP300
45butyrate456.7IL8, EP300, JUN, MPO, CD40, CD14
46retinoic acid45 247.5THBD, MPO, CSF2, CSF1, CREBBP, NME1
47serine456.4THBD, CREBBP, CSF1, IL8, EP300, CD14
48cysteine456.4JUN, EP300, IL8, CSF2, CSF1, CREBBP
49pge2456.3JUN, EP300, IL8, CREBBP, CSF2, CSF1
50vegf455.9IL8, THBD, MPO, JUN, CD40, CD14

GO Terms for genes affiliated with Monocytic Leukemia

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16Gene Ontology
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Cellular components related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:0001239.2CREBBP, EP300
2transcription factor complexGO:0056678.7CREBBP, EP300, JUN
3extracellular spaceGO:0056157.6CD40, THBD, MPO, IL8, CSF2, CSF1

Biological processes related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:0107449.8CSF1, CSF2
2N-terminal peptidyl-lysine acetylationGO:0180769.7CREBBP, EP300
3response to tumor necrosis factorGO:0346129.7CD14, EP300
4positive regulation of DNA bindingGO:0433889.7NME1, EP300
5histone acetylationGO:0165739.7KAT6B, CREBBP
6positive regulation of monocyte differentiationGO:0456579.6CSF1, JUN
7positive regulation by host of viral transcriptionGO:0439239.5EP300, JUN
8chromatin organizationGO:0063259.4KAT6B, EP300, CREBBP
9inflammatory responseGO:0069549.3CD40, CD14, CSF1, IL8
10regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.2CREBBP, EP300
11response to cAMPGO:0515919.2THBD, JUN, NME1
12positive regulation of DNA replicationGO:0457409.1CSF2, JUN
13cellular response to lipopolysaccharideGO:0712229.1CD40, CD14, CSF2, IL8
14response to lipopolysaccharideGO:0324969.0JUN, MPO, THBD
15innate immune responseGO:0450878.3JUN, EP300, CSF1, CREBBP, CD14

Molecular functions related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:0164079.3CREBBP, EP300, KAT6B
2histone acetyltransferase activityGO:0044029.1KAT6B, EP300, CREBBP
3RNA polymerase II activating transcription factor bindingGO:0011028.7JUN, EP300, CREBBP
4transcription coactivator activityGO:0037138.7CREBBP, EP300, JUN
5transcription factor bindingGO:0081348.1CREBBP, EP300, JUN, KAT6B
6protein bindingGO:0055156.0THBD, KAT6B, JUN, EP300, IL8, CSF2

Products for genes affiliated with Monocytic Leukemia

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Sources for Monocytic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet