MCID: MNC007
MIFTS: 57

Monocytic Leukemia malady

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Summaries for Monocytic Leukemia

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Wikipedia:65 Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the... more...

MalaCards based summary: Monocytic Leukemia, also known as schilling's leukemia, is related to sarcoma and langerhans-cell histiocytosis. An important gene associated with Monocytic Leukemia is KAT6B (K(lysine) acetyltransferase 6B), and among its related pathways are Hematopoietic cell lineage and NF-kappa B signaling pathway. The compounds gm-csf and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are other and adipose tissue.

Aliases & Classifications for Monocytic Leukemia

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Monocytic Leukemia, Aliases & Descriptions:

Name: Monocytic Leukemia 8 44 62
 
Schilling's Leukemia 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:8527
ICD9CM27 206.8
ICD1025 C93

Related Diseases for Monocytic Leukemia

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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
monocytic leukemia

Diseases related to Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.0CSF1, EP300
2langerhans-cell histiocytosis30.6CD40, CSF1
3refractory anemia30.4CSF1, CSF2
4myeloma30.3CD40, CD14, CSF1, CSF2
5leukemia30.2KAT6B, MPO, JUN, EP300, CSF2, CSF1
6acute pancreatitis30.2MPO, IL8, CD14
7non-hodgkin lymphoma30.2CSF2, CD14, CD40
8acute myelomonocytic leukemia30.1CREBBP, CSF1, MPO
9neutropenia30.0CD40, CSF1, CSF2, MPO
10myelodysplastic syndromes29.8MPO, EP300, CSF2, CSF1, CREBBP
11retinoblastoma29.8JUN, EP300, CREBBP, NME1
12t-cell leukemia29.6CD40, CREBBP, EP300, JUN
13acute monoblastic leukemia29.5THBD, MPO, EP300, CSF1, CREBBP, NME1
14acute lymphoblastic leukemia29.2MPO, JUN, EP300, CSF2, CREBBP, CD40
15myeloid leukemia29.2MPO, JUN, CSF2, CSF1, CREBBP, NME1
16acute monocytic leukemia11.2
17chronic monocytic leukemia10.5
18peripheral vascular disease10.4MPO
19polyarteritis nodosa10.4MPO
20felty's syndrome10.4CSF2
21capillary leak syndrome10.4CSF2
22aleukemic monocytic leukemia cutis10.4
23periodontitis10.4IL8
24subacute monocytic leukemia10.4
25histiocytosis10.4
26lung cancer10.4CSF2
27churg-strauss syndrome10.3THBD, MPO
28cyclic hematopoiesis10.3CSF1, CSF2
29extrinsic allergic alveolitis10.3CD14, IL8
30skin disease10.3MPO
31arteriosclerosis10.3CD14, CD40
32pulmonary alveolar proteinosis10.3CSF1, CSF2
33stroke, ischemic10.3CSF1, THBD
34pancytopenia10.3CSF1, CSF2
35peptic ulcer disease10.3CD14, IL8
36adult respiratory distress syndrome10.3THBD, IL8
37lupus nephritis10.3CD40, CSF1, THBD
38myelofibrosis10.3
39lymphoblastic leukemia10.3
40acute myocardial infarction10.2CD40, CD14, THBD
41rubinstein-taybi syndrome10.2EP300, CREBBP
42allergic rhinitis10.2MPO, IL8
43megakaryocytic leukemia10.2CSF2, MPO
44wegener's granulomatosis10.2CD14, MPO
45bronchiectasis10.2IL8, MPO
46vasculitis10.2THBD, MPO, CD14
47connective tissue disease10.2CD40, MPO, THBD
48chronic granulomatous disease10.2CSF2, MPO
49bronchitis10.2IL8, MPO
50acute myeloid leukemia10.2

Graphical network of the top 20 diseases related to Monocytic Leukemia:



Diseases related to monocytic leukemia

Symptoms for Monocytic Leukemia

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Drugs & Therapeutics for Monocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Monocytic Leukemia

Search NIH Clinical Center for Monocytic Leukemia

Genetic Tests for Monocytic Leukemia

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Anatomical Context for Monocytic Leukemia

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MalaCards organs/tissues related to Monocytic Leukemia:

32
Monocytes, Myeloid, Bone, Bone marrow, Skin, T cells, Spinal cord, Liver, B cells, Spleen, Lung, Prostate, Testes, Pituitary

Animal Models for Monocytic Leukemia or affiliated genes

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Publications for Monocytic Leukemia

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Articles related to Monocytic Leukemia:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. (23995854)
2013
2
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
3
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
4
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
5
Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. (21779573)
2011
6
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
7
The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. (19264921)
2009
8
Significance of transmission electron microscopy in subtyping of monocytic leukemia. (19274583)
2009
9
A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)
2008
10
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
11
Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. (19330074)
2008
12
Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. (18928586)
2008
13
Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. (16786142)
2006
14
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
15
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
16
A novel therapeutic strategy against monocytic leukemia with deoxyadenosine analogs and adenosine deaminase inhibitors. (11697650)
2001
17
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
18
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
19
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
20
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. (10497217)
1999
21
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. (10022809)
1999
22
Transient expression of M-CSF is important for osteoclast-like cell differentiation in a monocytic leukemia cell line. (9015756)
1997
23
Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia]. (10743082)
1997
24
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. (8667638)
1996
25
Tetrasomy 8 and t(1;11)(p32;q24) in acute myelo-monocytic leukemia with extensive leukemic cutaneous involvement. (8833413)
1996
26
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia. (8721686)
1996
27
Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia. (8535230)
1995
28
Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line. (8412297)
1993
29
Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937. (8389212)
1993
30
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
31
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
32
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. (1531307)
1992
33
Induction of interdigitating reticulum cell-like differentiation in human monocytic leukemia cells by conditioned medium from IL-2-stimulated helper T-cells. (1355319)
1992
34
Synthesis of active metabolite(s) from 1 alpha-hydroxyvitamin D3 by human monocytic leukemia cells. (1516717)
1992
35
Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia. (2129119)
1990
36
Letterer-Siwe disease and subacute monocytic leukemia. (2808842)
1989
37
Phenotyping of acute myelomonocytic (AMMOL) and monocytic leukemia (AMOL): association of T-cell-related antigens and skin-infiltration in AMOL. (2685474)
1989
38
Establishment of an etoposide (VP-16)-resistant subline of THP-1 human monocytic leukemia cell line. (2727988)
1989
39
Regulation of interleukin-1 beta and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1. (2801310)
1989
40
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
41
Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. (3855620)
1985
42
Massive metastatic pulmonary calcification in an infant with aleukemic monocytic leukemia. (2423997)
1985
43
Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin. (2989063)
1985
44
Cytochemical, functional, and proliferative characteristics of promonocytes and monocytes from patients with monocytic leukemia. (6223673)
1983
45
Pure acute monocytic leukemia. A study of 12 cases. (304666)
1977
46
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
47
Monocytic leukemia as a cause of acute respiratory obstruction. (4521037)
1974
48
Monocytic leukemia in cattle. I. Cytological observations of two cases. (5234777)
1967
49
Orbital reticulum-cell sarcoma with monocytic leukemia. Report of two cases. (14476366)
1962
50
Acute monocytic leukemia responsive to ACTH therapy. (13002763)
1952

Variations for Monocytic Leukemia

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Expression for genes affiliated with Monocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Monocytic Leukemia

Search GEO for disease gene expression data for Monocytic Leukemia.

Pathways for genes affiliated with Monocytic Leukemia

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Pathways related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CSF2, CSF1, CD14
29.3CD40, CD14, IL8
39.1IL8, CSF2, CD14
4
Show member pathways
9.1IL8, CSF2, CD14
59.1EP300, CREBBP, NME1
69.0MPO, EP300, CREBBP
7
Show member pathways
9.0CREBBP, IL8, EP300
88.8CD14, IL8, JUN
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.8JUN, IL8, CD14
108.8CSF1, CSF2, JUN
118.8JUN, EP300, IL8
128.8JUN, EP300, IL8
138.7JUN, EP300, CREBBP
148.7JUN, EP300, CREBBP
158.7JUN, EP300, CREBBP
16
Show member pathways
DNA damage Role of SUMO in p53 regulation60
8.7JUN, EP300, CREBBP
17
Show member pathways
8.7JUN, EP300, CREBBP
188.7JUN, EP300, CREBBP
19
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
8.7JUN, EP300, CREBBP
208.7CREBBP, EP300, JUN
218.7CREBBP, EP300, JUN
228.7CREBBP, EP300, JUN
238.7CREBBP, EP300, JUN
24
Show member pathways
FOXA transcription factor networks37
8.7CREBBP, EP300, JUN
25
Show member pathways
8.7CREBBP, EP300, JUN
268.7CREBBP, EP300, JUN
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.6JUN, IL8, CSF2
28
Show member pathways
Immune response MIF in innate immunity response60
8.5JUN, EP300, IL8, CD14
298.4IL8, EP300, JUN, THBD
30
Show member pathways
8.4CD14, CREBBP, EP300, JUN
318.4MPO, IL8, CSF2, CD14, CD40
328.3JUN, EP300, CREBBP, CD40
338.3JUN, EP300, CREBBP, CD40
34
Show member pathways
8.3JUN, IL8, CSF2, CD14
358.3JUN, IL8, CSF2, CSF1
368.2JUN, EP300, CREBBP, NME1
378.1JUN, EP300, CSF2, CREBBP
38
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
8.1CREBBP, IL8, EP300, JUN
398.1JUN, EP300, IL8, CREBBP
40
Show member pathways
8.1JUN, EP300, IL8, CREBBP
418.1JUN, EP300, IL8, CREBBP
42
Show member pathways
8.1CREBBP, IL8, EP300, JUN
43
Show member pathways
8.1JUN, EP300, IL8, CREBBP
44
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.9JUN, EP300, IL8, CREBBP, CD14
457.8CD40, CREBBP, CSF2, EP300, JUN
46
Show member pathways
7.7JUN, IL8, CSF2, CSF1, CREBBP
477.6JUN, EP300, IL8, CSF2, CREBBP
48
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.5JUN, EP300, IL8, CREBBP, CD14, CD40
49
Show member pathways
7.3JUN, EP300, IL8, CSF2, CSF1, CREBBP
50
Show member pathways
6.7CD40, JUN, EP300, IL8, CSF2, CSF1

Compounds for genes affiliated with Monocytic Leukemia

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Compounds related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2810.2CSF1, CD14, IL8, CSF2
2prednisolone44 28 1111.1CD14, CD40, CSF1, MPO, THBD
3budesonide44 50 1111.0MPO, IL8, CSF2, CSF1
4il 10449.0CD40, CSF1, CSF2, IL8
5fluticasone propionate44 50 61 1112.0MPO, IL8, CSF2, CSF1
6triptolide448.9CD14, CD40, IL8, JUN
7methacholine44 50 1110.8IL8, MPO, CSF2, CD14
8mitoxantrone44 50 1110.8CSF2, MPO, CREBBP, CSF1
9pentoxifylline44 119.8THBD, MPO, IL8, CSF2, CD14
10endotoxin448.8CD40, CD14, CSF2, IL8, THBD
11n-formylmethionyl-leucylphenylalanine448.7THBD, CSF2, IL8, CSF1, MPO
12mannose448.7CSF2, CSF1, CD14, CD40, CREBBP
13paraffin448.7CSF1, MPO, THBD, NME1, CD14, CD40
14fmlp448.6CD14, CSF1, MPO, IL8, CSF2
15dmso448.6THBD, MPO, CSF2, NME1, CSF1
16neopterin448.6THBD, CSF1, CD14, CD40, IL8, CSF2
17ionomycin448.4EP300, CSF2, CSF1, CD40, JUN
18cyclophosphamide44 50 1110.3CSF1, THBD, MPO, CSF2, CREBBP, CD40
19herbimycin a44 619.3CSF2, CD40, CD14, JUN, IL8
20ly294002448.2IL8, JUN, CSF1, CD40, CD14, EP300
21wortmannin448.2CD14, CD40, CSF2, CSF1, JUN, EP300
22histamine44 28 2410.1CSF1, CD40, CSF2, IL8, MPO, THBD
23retinoid448.1EP300, CD14, JUN, THBD, CSF1, CREBBP
24heparin44 28 24 1111.1CSF2, CSF1, MPO, THBD, CD14, IL8
255fluorouracil448.1CREBBP, MPO, CSF2, CSF1, NME1
26lactate448.0THBD, MPO, IL8, CSF2, CSF1, CD14
27cyclosporin a44 28 619.9THBD, JUN, IL8, CSF2, CD40, CD14
28cisplatin44 50 61 1110.9CSF1, CREBBP, CSF2, NME1, EP300, MPO
29chloramphenicol44 2 50 1110.9CD40, CSF1, JUN, MPO, THBD
30vitamin d447.9EP300, CREBBP, JUN, THBD, CD14, CSF2
31calcitriol44 61 24 1110.9THBD, JUN, EP300, CSF1, NME1, CD14
32superoxide44 248.8CD14, MPO, CSF2, CSF1, CREBBP, CD40
33etoposide44 50 61 1110.8CSF1, NME1, CREBBP, CSF2, EP300, JUN
34creatinine447.8CREBBP, THBD, MPO, EP300, CSF1, NME1
35cycloheximide447.8CSF2, CSF1, IL8, CD14, JUN, THBD
36nitric oxide44 24 119.7CREBBP, IL8, EP300, MPO, THBD, CD40
37actinomycin d447.7CSF2, THBD, JUN, EP300, IL8, CSF1
38h2o2447.6IL8, CD40, CSF1, JUN, MPO, THBD
39phosphatidylinositol447.6CSF2, CSF1, CD40, EP300, JUN, CD14
40rantes447.5CSF1, CREBBP, IL8, JUN, CSF2, CD40
41dexamethasone44 50 28 1110.4IL8, THBD, JUN, CSF2, CD40, NME1
42pd 98,059447.1CREBBP, CD40, CD14, CSF2, IL8, EP300
43estrogen447.1THBD, JUN, NME1, CREBBP, CSF1, CSF2
44tyrosine446.8CSF1, THBD, NME1, CREBBP, CSF2, EP300
45butyrate446.7IL8, EP300, JUN, MPO, CD40, CD14
46retinoic acid44 247.5THBD, MPO, CSF2, CSF1, CREBBP, NME1
47serine446.4THBD, CREBBP, CSF1, IL8, EP300, CD14
48cysteine446.4JUN, EP300, IL8, CSF2, CSF1, CREBBP
49pge2446.3JUN, EP300, IL8, CREBBP, CSF2, CSF1
50vegf445.9IL8, THBD, MPO, JUN, CD40, CD14

GO Terms for genes affiliated with Monocytic Leukemia

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Cellular components related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:0001239.2CREBBP, EP300
2transcription factor complexGO:0056678.7CREBBP, EP300, JUN
3extracellular spaceGO:0056157.6CD40, THBD, MPO, IL8, CSF2, CSF1

Biological processes related to Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:0107449.8CSF1, CSF2
2N-terminal peptidyl-lysine acetylationGO:0180769.7CREBBP, EP300
3response to tumor necrosis factorGO:0346129.7CD14, EP300
4positive regulation of DNA bindingGO:0433889.7NME1, EP300
5histone acetylationGO:0165739.7KAT6B, CREBBP
6positive regulation of monocyte differentiationGO:0456579.6CSF1, JUN
7positive regulation by host of viral transcriptionGO:0439239.5EP300, JUN
8chromatin organizationGO:0063259.4KAT6B, EP300, CREBBP
9inflammatory responseGO:0069549.3CD40, CD14, CSF1, IL8
10regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.2CREBBP, EP300
11response to cAMPGO:0515919.2THBD, JUN, NME1
12positive regulation of DNA replicationGO:0457409.1CSF2, JUN
13cellular response to lipopolysaccharideGO:0712229.1CD40, CD14, CSF2, IL8
14response to lipopolysaccharideGO:0324969.0JUN, MPO, THBD
15innate immune responseGO:0450878.3JUN, EP300, CSF1, CREBBP, CD14

Molecular functions related to Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:0164079.3CREBBP, EP300, KAT6B
2histone acetyltransferase activityGO:0044029.1KAT6B, EP300, CREBBP
3RNA polymerase II activating transcription factor bindingGO:0011028.7JUN, EP300, CREBBP
4transcription coactivator activityGO:0037138.7CREBBP, EP300, JUN
5transcription factor bindingGO:0081348.1CREBBP, EP300, JUN, KAT6B
6protein bindingGO:0055156.0THBD, KAT6B, JUN, EP300, IL8, CSF2

Products for genes affiliated with Monocytic Leukemia

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Sources for Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet