Monocytic Leukemia malady

Wikipedia: Monocytic leukemia is a type of myeloid leukemia characterized by a dominance of monocytes in the...⁴⁴ more...

MalaCards: Monocytic Leukemia, also known as schilling's leukemia, is related to acute monocytic leukemia and histiocytosis. An important gene associated with Monocytic Leukemia is KAT6A (K(lysine) acetyltransferase 6A), and among its related pathways are Colorectal cancer and Pertussis. The compounds vincristine and gp 130 have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and skin, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

monocytic leukemia 6 32 43 schilling's leukemia 6

Diseases related to monocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 847)

id	Related Disease	Score	Top Affiliating Genes
1	acute monocytic leukemia	37.5	ZNF580, PIM1, KIAA0100, RBM12, VCL, MYC
2	histiocytosis	28.1	VIM, RARA, LIF, CD1A, CD40, ITGAL
3	mediastinitis	28.0	VIM, MYC, MPO, JUN, MLL, MLLT10
4	t-cell leukemia	27.8	MYC, BIRC5, BCL2, BCL2L1, CEBPB, JUN
5	adult t-cell leukemia	27.7	PIM1, MYC, BCL2, BCL2L1, CD40, ITGAL
6	myelodysplastic syndrome	27.7	RARA, BIRC5, MPO, MLL, FLT3, FASLG
7	emphysema	26.7	VEGFA, BMP6, BCL2L1, BAX, MPO, MLLT10
8	acute lymphocytic leukemia	25.5	VEGFA, LPL, MYC, BIRC5, BCL2, BAX
9	pertussis	25.0	BMP6, PARP1, KAT5, MRC1, JUN, CD14
10	hematopoiesis	24.0	PIM1, VEGFA, BMP6, RARS, LIF, BIRC5
11	leukemia	22.7	ZNF580, PIM1, KLF4, NCOA2, KIAA0100, SELP
12	retinoblastoma	21.6	SERPINB2, VIM, VEGFA, MYC, BMP6, RARA
13	lymphocytic leukemia	19.7	SELP, VIM, VEGFA, LPL, VCAM1, MYC
14	letterer-siwe disease	14.1	RARA, LIF, CD1A, CD40, CSF1
15	neonatal leukemia	14.1	KAT6A, CREBBP, EP300
16	acute megakaryoblastic leukemia	14.1	MPO, MLL, CSF2, RUNX1, GATA1
17	acute myelomonocytic leukemia	14.1	MPO, MLL, CBFB, CREBBP, CSF1, CSF1R
18	joint disorders	14.0	SERPINB2, IL1R1, IL6, TNF, CSF1
19	newborn respiratory distress syndrome	14.0	MPO, ITGAM, IL1B, IL6, IL8, THBD
20	idiopathic pulmonary fibrosis	14.0	MPO, IL1B, IL1R1, IL8, IFNG, TNF
21	churg-strauss syndrome	14.0	MPO, FAS, IFNG, CYSLTR1, LTF, THBD
22	bagassosis	14.0	IL1B, IL6, IL8, TNF
23	obstructive jaundice	14.0	CD14, ITGAL, ITGAM, IL1R1, IL6, IL8
24	bronchiectasis	14.0	MPO, CD14, IL1B, IL6, IL8, IFNG
25	atopic dermatitis	14.0	SELP, VCAM1, CD14, CD40, ITGAM, IL8
26	down syndrome	14.0	MYC, RARA, MLL, FLT3, CSF3R, RUNX1
27	muckle-wells syndrome	14.0	IL1B, IL1R1, IL8, CASP1, TNFRSF1A
28	wells syndrome	13.9	IL1B, IL1R1, IL8, CASP1, TNFRSF1A
29	arterial occlusive disease	13.9	SELP, VCAM1, CCL2, F3, THBD
30	dengue shock syndrome	13.9	IL1B, IL6, CCL2, TNF, THBD
31	adult respiratory distress syndrome	13.9	IL1R1, IL8, TNF, THBD
32	eosinophilic pneumonia	13.9	IL1B, IL6, IL8, CCL2, IFNG, TNF
33	leukemia, acute nonlymphocytic	13.9	SERPINB2, MLL, ABCB1, ABCC1
34	autoimmune hemolytic anemia	13.9	MYC, MPO, IFNB1, IFNG, F3, TNF
35	spondylarthropathy	13.9	ITGAL, ITGAM, IL1B, IL6, IL8, TNF
36	lymphatic system disease	13.9	IL6, IFNG, TNF, CSF1
37	cystic fibrosis lung disease	13.9	MPO, IL1B, IL1R1, IL8, TNF
38	familial cold autoinflammatory syndrome	13.9	IL1B, IL1R1, CASP1, TNFRSF1A
39	leukocyte-adhesion deficiency syndrome	13.9	SELP, ITGAD, ITGAL, ITGAM, IL1B
40	guillain-barre syndrome	13.9	CD1A, FAS, IFNG, TNF, TNFRSF1A, CXCL12
41	intrauterine infections	13.9	IL1B, IL1R1, IL6, IL8, IFNG, TNF
42	mastitis	13.9	BCL2L1, CD14, IL1B, IL1R1, IL6, IL8
43	immune-complex glomerulonephritis	13.9	SELP, VCAM1, MPO, ITGAL
44	common wart	13.9	IL6, IL8, IFNB1, TP53
45	acute biphenotypic leukemia	13.9	MPO, MLL, MLLT10, F3, ABL1
46	jaundice	13.9	CD14, ITGAL, ITGAM, IL1B, IL1R1, IL6
47	paratyphoid fever	13.9	IL1B, IL1R1, IFNG, CASP1, TNF, TNFRSF1A
48	complex regional pain syndrome	13.9	CD14, IL1B, IL6, IFNG, TNF, TNFRSF1A
49	aphthous stomatitis	13.9	CD40, IL1B, IL6, IFNG, TNF
50	spermatocele	13.9	IL6, IL8, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to monocytic leukemia:

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MGI Mouse Phenotypes related to monocytic leukemia:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	SELP, LPL, LIF, CD14, CBFB, CYSLTR1
2	craniofacial phenotype	MP:0005382	10.1	KLF4, KAT6A, KAT6B, KAT7, MLL, MAPK8
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	KLF4, NCOA2, FASLG, IFNG, ID2, CASP8
4	other phenotype	MP:0005395	9.2	RARA, HSPG2, TNFRSF1A, PTGS2, CTSB, ABCB1
5	embryogenesis phenotype	MP:0005380	8.9	NCOA2, VIM, VCL, MYC, BIRC5, PARP1
6	limbs/digits/tail phenotype	MP:0005371	8.7	VEGFA, VCL, RARA, BAX, KAT6A, KAT6B
7	renal/urinary system phenotype	MP:0005367	8.7	SELP, RARA, BCL2, BAX, CEBPB, CDKN1A
8	no phenotypic analysis	MP:0003012	8.3	NCOA2, VEGFA, VCAM1, MYC, MYO1F, PARP1
9	liver/biliary system phenotype	MP:0005370	8.3	VEGFA, LPL, LIF, KAT6A, MLL, IL1R1
10	adipose tissue phenotype	MP:0005375	8.2	LPL, MYC, LIF, BCL2, CEBPB, KAT6B
11	hematopoietic system phenotype	MP:0005397	8.0	PIM1, SERPINB2, BCL2, BCL2L1, ZC3H12A, KAT6A
12	reproductive system phenotype	MP:0005389	8.0	KLF4, NCOA2, VEGFA, RARA, LIF, SCYL1
13	hearing/vestibular/ear phenotype	MP:0005377	7.6	MYC, RARA, PARP1, BCL2, BAX, KAT6B
14	immune system phenotype	MP:0005387	7.6	NCOA2, SELP, SERPINB2, VIM, MYO1F, RARA
15	tumorigenesis	MP:0002006	7.5	KLF4, MYC, RARA, BCL2, BCL2L1, CEBPB
16	normal phenotype	MP:0002873	7.4	KLF4, VEGFA, MYC, RARA, CEBPB, CD40
17	nervous system phenotype	MP:0003631	7.3	SELP, VCL, MYC, RARA, LIF, PARP1
18	digestive/alimentary phenotype	MP:0005381	7.1	KLF4, VEGFA, VCL, MYC, RARA, LIF
19	behavior/neurological phenotype	MP:0005386	7.1	KLF4, NCOA2, SELP, VIM, LIF, SCYL1
20	integument phenotype	MP:0010771	7.0	KLF4, NCOA2, SELP, MYC, LIF, PARP1
21	skeleton phenotype	MP:0005390	6.8	VEGFA, MYC, BMP6, RARA, LIF, SCYL1
22	growth/size phenotype	MP:0005378	6.1	PIM1, NCOA2, SELP, SERPINB2, LPL, VCAM1
23	vision/eye phenotype	MP:0005391	6.0	SELP, VIM, VEGFA, RARA, LIF, BCL2
24	muscle phenotype	MP:0005369	5.7	SERPINB2, VIM, VEGFA, LPL, VCL, MYC
25	cardiovascular system phenotype	MP:0005385	5.5	SELP, VIM, VEGFA, LPL, VCAM1, VCL
26	mortality/aging	MP:0010768	5.2	KLF4, SELP, SERPINB2, VEGFA, LPL, VCAM1
27	homeostasis/metabolism phenotype	MP:0005376	3.6	KLF4, SELP, SERPINB2, VIM, VEGFA, LPL
28	cellular phenotype	MP:0005384	3.0	PIM1, KLF4, SELP, VIM, VEGFA, VCAM1

Articles related to monocytic leukemia:

(show top 50)    (show all 97)

id	Title	Authors	Year	Affiliating Genes
1	Immunohistochemical analysis of monocytic leukemias: usefulness of CD14 and Kruppel-like factor 4, a novel monocyte marker. (21502426)	Klco J.M.... Frater J.L.	2011	KLF4
2	Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation. (21586674)	Barilli A.... Dall'Asta V.	2011	SLC7A7
3	Quantitative assessment of MLAA-34 expression in diag nosis and prognosis of acute monocytic leukemia. (21240483)	Zhao J.... Gu L.	2011	CAB39L
4	Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. (21399634)	Yan X.J.... Chen S.J.	2011	DNMT3A
5	A novel unbalanced whole-arm translocation der(3;10)( q10;q10) in acute monocytic leukemia. (20471517)	Yamamoto K.... Matsui T.	2010	MPO
6	Retinoblastoma protein-interacting zinc finger 1 (RIZ 1) regulates the proliferation of monocytic leukemia cells via activation of p5 3. (20594067)	Shadat N.M.... Yokochi T.	2010	TP53, PRDM2
7	Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest. (19001415)	Rokudai S.... Kitabayashi I.	2009	TP53, CDKN1A, EP300
8	Expression of genes psma6 and slc25a4 in patients wi th acute monocytic leukemia (19840444)	Chen Y.X.... Ma X.R.	2009	PSMA2, PSMA6, SLC25A4
9	Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (18592235)	Zhang P.Y.... Li W.B.	2009	CAB39L
10	Antiglaucoma drug GLC756 and its effect on cellular cAMP and tumor necrosis factor alpha release in vitro of activated human monocytic leukemia cells. (19333701)	Laengle U.W.... Roman D.	2009	TNF
11	A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)	Kurosu T.... Miura O.	2008	MLL, SEPT9
12	Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis. (18754862)	Katsumoto T.... Kitabayashi I.	2008	KAT6A
13	Bioinformatic analysis and identification for a nove l antigen MLAA-22 in acute monocytic leukemia (18549609)	Zhou F.L.... Wang J.L.	2008	KIAA0100
14	Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells. (18418899)	Yamamoto M.... Matsumura F.	2008	TNFSF13B
15	Effects of FMS-like tyrosine kinase 3 targeted RNA interference on proliferation and apoptosis of acute monocytic leukemia cell line THP-1 (18021537)	Lu J.... Xu P.R.	2007	FLT3
16	Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. (16786142)	Park C.... Choi Y.H.	2006	E2F1
17	Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. (16518848)	Sindt A.... Delabesse E.	2006	HOXA9
18	In vitro stimulation of specific antileukemia T-cell response by dendritic cells derived from CD14+ acute monocytic leukemia cells (16552959)	Sheng L.X.... Wu H.Q.	2005	TNF, CD14, CSF2
19	Acute monocytic leukemia after orthotopic liver transplantation: clinical features, molecular genetics, and significance thereof (16686070)	Zhang G.S.... Yang J.J.	2005	PIM1
20	The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22. (15897884)	Taki T.... Hayashi Y.	2005	MLL
21	Serological identification of immunogenic antigens in acute monocytic leukemia. (15755502)	Chen G.... Yao L.B.	2005	CAB39L, MYH7B, KIAA0100
22	Butyrate increases apoptosis induced by different ant ineoplastic drugs in monocytic leukemia cells. (15528887)	Ramos M.G.... Alvarez-Leite J.I.	2004	CASP3
23	WT1 gene expression: useful marker for minimal residual disease in childhood myelodysplastic syndromes and juvenile myelo-monocytic leukemia? (15182334)	Bader P.... Biondi A.	2004	WT1
24	Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema. (12555219)	Nakamura F.... Mitani K.	2003	MLLT10
25	Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia. (14576638)	Klemke C.D.... Goerdt S.	2003	CD1A
26	Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia. (12645654)	Chen S.... Pan J.	2003	NUP98
27	Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1). (14582708)	Wagsater D.... Dimberg J.	2003	ID2
28	Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937. (12553012)	Abdelhaleem M.	2002	CASP3, BCL2L1
29	Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia? (12547160)	Morerio C.... Panarello C.	2002	MLL, ABI1
30	Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b). (11530805)	Kakazu N.... Abe T.	2001	NUP98
31	Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma. (11739196)	Lemmink H.H.... Vellenga E.	2001	IL6, IFNG
32	Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)	Kitabayashi I.... Ohki M.	2001	EP300, KAT6A
33	Acute monocytic leukemia with a novel 10;11 rearrange ment resolved by fluorescence in situ hybridization. (10731585)	Sinclair E.J.... Watmore A.E.	2000	MLL
34	Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation. (11066077)	Odero M.D.... Rowley J.D.	2000	MLLT3
35	A 63 kDa tumor necrosis factor inhibitor released from a human monocytic leukemia cell line, THP-1. (10100747)	Aso H.... Mizugaki M.	1999	TNF
36	Role of CD14 expression in the differentiation-apoptosis switch in human monocytic leukemia cells treated with 1alpha,25-dihydroxyvitamin D3 or dexamethasone in the presence of transforming growth factor beta1. (10547074)	Kanatani Y.... Honma Y.	1999	ITGAM, CD14, BMP6
37	THP-1 monocytic leukemia cells express Fas ligand constitutively and kill Fas-positive Jurkat cells. (10573130)	Bremner T.A.... Wyche J.H.	1999	FAS, FASLG
38	Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line. (9885903)	Matsumoto M.... Akira S.	1998	CEBPB, CCL3
39	Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. (9478929)	Hoshino M.... Shimizu T.	1998	MAPK10, CYSLTR1
40	Secondary monocytic leukemia with rearrangement of the MLL gene occurring during the course of adult T-cell leukemia. (9846017)	Obama K.... Niina K.	1998	MLL
41	Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-alpha-induced apoptosis. (9428804)	Dong J.... Tsuruo T.	1998	CARD16
42	c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells. (9264404)	Dong J.... Tsuruo T.	1997	MYC, TNF
43	Differentiation inhibitory factor nm23 as a new prognostic factor in acute monocytic leukemia. (8896423)	Yokoyama A.... Honma Y.	1996	MYC, NME1
44	Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67). (8732670)	Grant S.... Jarvis W.D.	1996	JUN
45	Infantile acute monocytic leukemia with tumor formation in the skin expressing adhesion molecules as seen by electronmicroscopy. (9021702)	Asano T.... Yamamoto M.	1996	VCL
46	Interleukin (IL)-6 signaling leads to phosphorylation of the small heat shock protein (Hsp)27 through activation of the MAP kinase and MAPKAP kinase 2 pathway in monocytes and monocytic leukemia cells. (7869766)	Belka C.... Brach M.A.	1995	MAPK10, IL6, HSPB1
47	Successful treatment of a 93-year-old patient with hy poplastic acute monocytic leukemia using macrophage colony-stimulating factor. (7758063)	Watanabe A.... Indo N.	1995	CSF1
48	A case of acute monocytic leukemia with t(11;17) invo lving a rearrangement of MLL-1 and a region proximal to the RARA gene. (8194047)	Reeves B.R.... Cotter F.	1994	RARA
49	A phorbol diester resistant monocytic leukemia cell line is PKC deficient. (1313072)	Ansari N.A.... Wu M.C.	1992	DYT10
50	A Val-Val sequence found in a human monocytic leukemia lysozyme. (11946554)	Thomsen J.... Malmquist J.	1972	LYZ

Genes related to monocytic leukemia according to GeneCards:

(show top 50)    (show all 140)

id	Symbol	Description	Score	GeneCards Section Context
1	KAT6A	K(lysine) acetyltransferase 6A	11.1	Aliases & Descriptions, Orthologs, Publications
2	KAT6B	K(lysine) acetyltransferase 6B	11.1	Orthologs, Aliases & Descriptions, Publications
3	AFF1	AF4/FMR2 family, member 1	11.0	Aliases & Descriptions
4	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
5	CD14	CD14 molecule	11.0	Publications
6	CRAT	carnitine O-acetyltransferase	11.0
7	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
8	RARA	retinoic acid receptor, alpha	11.0	Publications
9	EP300	E1A binding protein p300	11.0	Publications
10	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0
11	THBD	thrombomodulin	11.0
12	MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	11.0	Publications
13	NUP98	nucleoporin 98kDa	11.0	Publications
14	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
15	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
16	MPO	myeloperoxidase	11.0	Publications
17	CREBBP	CREB binding protein	11.0	Publications
18	JUN	jun proto-oncogene	11.0	Publications
19	TNF	tumor necrosis factor	11.0	Publications
20	IL8	interleukin 8	11.0	Publications
21	ZNF580	zinc finger protein 580	11.0
22	KIAA0100	KIAA0100	11.0	Publications
23	ZC3H12A	zinc finger CCCH-type containing 12A	11.0	Functions
24	ITGAD	integrin, alpha D	11.0
25	MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	11.0	Publications
26	HOXA9	homeobox A9	11.0	Publications
27	PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	11.0	Publications
28	MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	11.0	UniProt Related, Publications
29	CD1A	CD1a molecule	11.0	Publications
30	ZC3H12D	zinc finger CCCH-type containing 12D	11.0	Functions
31	PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	11.0	Publications
32	ZC3H12C	zinc finger CCCH-type containing 12C	11.0	Functions
33	FDPS	farnesyl diphosphate synthase	11.0
34	LTC4S	leukotriene C4 synthase	11.0
35	CAB39L	calcium binding protein 39-like	11.0	Publications, UniProt Related
36	LTB4R	leukotriene B4 receptor	11.0	Publications
37	CLP1	CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)	11.0
38	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.0	Publications
39	MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	11.0	Publications
40	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
41	MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	11.0	Publications
42	PIM1	pim-1 oncogene	11.0	Publications
43	ABI1	abl-interactor 1	11.0	Publications
44	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	11.0	Publications
45	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Publications
46	VCL	vinculin	11.0	Publications
47	CSF3R	colony stimulating factor 3 receptor (granulocyte)	11.0	Publications
48	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0	Publications
49	CBFB	core-binding factor, beta subunit	11.0	Publications
50	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications

Pathways related to monocytic leukemia according to GeneDecks:

(show top 50)    (show all 254)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.6	MAPK8, FOS
2	Pertussis20	10.6	JUN, CD14, ITGAM, FOS, IL1B, IL6
3	Amoebiasis20	10.4	ITGAM, IL1B, IL1R1, IL8, HSPB1, TLR4
4	Toll-like receptor signaling pathway20	10.4	CD40, CD14, FOS, IL1B, IL6, IL8
5	Akt Signaling36	10.3	CCL2, CCL3, TNF, TNFRSF1A, TNFSF13B, CXCL12
6	Bacterial infections in CF airways41	10.3	CTSB, IL1R1
7	14-3-3 Induced Apoptosis36	10.3	TLR4, CYCS, BCL2, JUN, FOS, IL1B
8	HMGB1 Pathway36	10.2	IL1R1, IL1B, FOS, JUN, MAPK10, TLR4
9	Influenza A20	10.2	JUN, NUP98, EP300, TLR4, CREBBP, CYCS
10	Immune response MIF in innate immunity response10	10.1	CD14, IL1B, IL6, IL8, MAPK8, MAPK10
11	Immune response_MIF in innate immunity response41	10.1	TP53, TNF, PTGS2, TLR4, EP300, IFNG
12	Chagas disease (American trypanosomiasis)20	10.0	FASLG, FAS, MAPK8, MAPK10, MAPK1, CCL2
13	Hematopoietic cell lineage20	10.0	CSF2, CSF1R, TNF, IL6, IL1R1, IL1B
14	Malaria20	9.9	ITGAL, CSF3, TLR4, TNF, IFNG, CCL2
15	RAR-Gamma-RXR-Alpha Degradation36	9.9	CSF2, CSF1, CXCL12, TNFSF13B, CCL3, MAPK10
16	Apoptosis20	9.8	TP53, BAX, TNFRSF1A, TNF, CYCS, IL1R1
17	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins41	9.8	BCL2, BCL2L1, BAX, MCL1, FAS, CASP8
18	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins10	9.8	CYCS, TNFRSF1A, SLC25A4, AIFM1, CASP8, FAS
19	Immune response_IL-1 signaling pathway41	9.7	JUN, PTGS2, TNF, F3, MAPK10, MAPK8
20	Tuberculosis20	9.7	BCL2, BAX, CEBPB, MRC1, CD14, ITGAM
21	Osteoclast differentiation20	9.7	TNFRSF1A, PPARG, JUN, CSF1, CSF1R, TNF
22	Immune response IL-1 signaling pathway10	9.6	PTGS2, TNF, JUN, FOS, IL1B, IL1R1
23	Rheumatoid arthritis20	9.5	VEGFA, JUN, ITGAL, FOS, IL1B, IL6
24	IL-6 Pathway36	9.4	MAPK1, CCL2, CCL3, TNFSF13B, CSF1, CSF2
25	Endothelin-1 Signaling Pathway36	9.3	CSF1R, CSF3, CSF1, CXCL12, MYC, BMP6
26	JAK-STAT Pathway36	9.3	BMP6, BCL2, BAX, JUN, FOS, FLT3
27	TGF-Beta Pathway36	9.3	CREBBP, CXCL12, EP300, JUN, BMP6, BAX
28	Apoptosis and survival_FAS signaling cascades41	9.3	CASP8, CYCS, BCL2, HSPB1, CASP3, MAPK8
29	Apoptosis and survival FAS signaling cascades10	9.3	BAX, FAS, MAPK8, BCL2, PARP1, FASLG
30	Tec Kinases Signaling36	9.3	BMP6, BCL2, BAX, ITGAD, ITGAL, ITGAM
31	MAPK Signaling36	9.1	MAPK8, IL1R1, MAPKAPK2, MAPK10, MAPK1, HSPG2
32	p53 Signaling36	9.1	EP300, E2F1, BCL2, BAX, CDKN1A, FOS
33	PEDF Induced Signaling36	9.0	BMP6, LIF, BCL2, BCL2L1, BAX, FOS
34	ILK Signaling36	9.0	ITGAD, ITGAM, JUN, CEBPB, MYO1F, MYH7B
35	ERK Signaling36	8.9	BMP6, MYC, ITGAD, ITGAL, ITGAM, FLT3
36	PAK Pathway36	8.9	IL6, IL8, MAPK8, MAPK10, CCL2, CCL3
37	Apoptosis and Autophagy3	8.8	PIM1, MYC, BIRC5, PARP1, BCL2, BCL2L1
38	Glucocorticoid Receptor Signaling36	8.7	JUN, CDKN1A, FOS, IL1B, IL1R1, IL6
39	all-trans-Retinoic Acid Signaling in Brain36	8.7	BMP6, RARA, LIF, BCL2, BAX, IL1B
40	Antioxidant Action of Vitamin-C36	8.6	JUN, FOS, IL1B, IL1R1, IL6, IL8
41	p38 Signaling36	8.6	BMP6, CCL2, CXCL12, TNFSF13B, TNFRSF1A, TNF
42	MIF Mediated Glucocorticoid Regulation36	8.6	IL6, CD14, IL1B, BAX, BCL2, BMP6
43	Cytokine-cytokine receptor interaction20	8.6	VEGFA, CSF3, CSF3R, CSF2, CSF1R, CSF1
44	Apoptosis Signaling Pathways37	8.5	BCL2, BCL2L1, BAX, CDKN1A, FASLG, FAS
45	MIF Regulation of Innate Immune Cells36	8.4	CSF1, CXCL12, TLR4, PTGS2, TNFSF13B, TNF
46	Molecular Mechanisms of Cancer36	8.3	IL1R1, IL6, MAPK8, MAPK1, CASP3, CASP8
47	Transcription_P53 signaling pathway41	8.2	MAPK10, HSPB1, MAPK8, FOS, BCL2, VEGFA
48	STAT3 Pathway36	8.2	TNFSF13B, CXCL12, CSF1, CSF1R, CSF2, CSF3
49	Rho Family GTPases36	8.1	CSF1R, CSF2, CSF3, ITGAD, ITGAL, ITGAM
50	Pathways in cancer20	7.6	MAPK1, CASP3, CASP8, TP53, CYCS, CREBBP

Compounds related to monocytic leukemia according to GeneDecks:

(show top 50)    (show all 514)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.6	MLL, IFNB1, CRAT, CSF2, ADA
2	gp 13032	10.4	PIM1, BMP6, LIF, BCL2L1, CEBPB, FLT3
3	fibrinogen32	10.2	SELP, SERPINB2, VCAM1, VCL, LIF, CEBPB
4	polymyxin b32	10.1	VCAM1, CD14, IL1B, IL6, IL8, CCL2
5	egcg32	10.1	BCL2L1, MCL1, MAPK8, MAPK10, HSPG2, CYCS
6	sp 60012532 42	11.1	VCAM1, CDKN1A, CD40, CASP3, TP53, CYCS
7	anisomycin32 42 9 9	12.9	MYC, JUN, FOS, IL1B, IL6, FASLG
8	h2o232	9.9	SERPINB2, LIF, MPO, CD40, ITGAL, ITGAM
9	epinephrine32 9 18 9	12.9	SELP, BMP6, ITGAM, FASLG, FAS, F3
10	tpck32	9.9	PARP1, BCL2L1, JUN, IL1B, IL6, IL8
11	arginine32	9.7	NCOA2, RARA, RARS, LIF, KAT5, CD14
12	sulindac sulfide32	9.6	BMP6, BCL2, BCL2L1, BAX, JUN, CASP3
13	il 1032	9.5	BMP6, LIF, CD40, IL1B, IL1R1, IL6
14	cyclic amp32 18	10.5	NCOA2, SERPINB2, VCL, RARS, LIF, CEBPB
15	polysaccharide32	9.5	SELP, LPL, VCAM1, BMP6, LIF, MRC1
16	diphenyleneiodonium32	9.5	VEGFA, VCAM1, MPO, JUN, IL1B, IL1R1
17	aspartate32	9.4	SELP, VIM, BMP6, RARA, CD14, MLL
18	cytochalasin d32 42	10.4	VIM, LPL, VCAM1, VCL, ITGAL, FOS
19	n acetylcysteine32	9.4	SELP, VCAM1, BIRC5, CEBPB, CDKN1A, CD40
20	heparin32 9 18 9	12.4	SERPINB2, VIM, LPL, VCL, LIF, MPO
21	cysteine32	9.3	SELP, VCL, RARA, LIF, PARP1, BCL2L1
22	endotoxin32	9.3	SERPINB2, LIF, CEBPB, CD14, CD40, ITGAL
23	histamine32 18	10.2	SELP, VIM, VCAM1, BMP6, RARS, MPO
24	sulforaphane32	9.2	PARP1, JUN, CDKN1A, MAPK8, MAPK1, CASP3
25	cyclosporin a32 42	10.2	SELP, SERPINB2, LPL, MYC, LIF, JUN
26	rapamycin32 42	10.1	PIM1, VIM, VEGFA, GTDC2, IL1R1, MAPK8
27	phosphoinositide32	9.0	VIM, VCL, RARA, BIRC5, BCL2L1, JUN
28	tgf beta132	8.7	VIM, VCAM1, BMP6, RARA, LIF, CDKN1A
29	gm-csf32	8.6	VEGFA, BMP6, LIF, BCL2L1, CD14, IL1B
30	daunorubicin32 9 9	10.6	MYC, BIRC5, BCL2, BCL2L1, BAX, MPO
31	ly29400232	8.5	VEGFA, RARA, JUN, ITGAM, FOS, IL1B
32	alanine32	8.5	PIM1, VCAM1, MYC, BMP6, RARA, BIRC5
33	vitamin d32	8.4	NCOA2, VIM, LPL, BMP6, RARA, RARS
34	noxa32	8.4	BIRC5, BCL2, BCL2L1, BAX, CDKN1A, MCL1
35	12-o-tetradecanoylphorbol 13-acetate32	8.3	SERPINB2, VCL, MYC, BMP6, RARA, RARS
36	n-(4-hydroxyphenyl)retinamide32	8.3	VIM, MYC, BMP6, RARA, RARS, PARP1
37	glutamate32	8.2	VIM, BMP6, CEBPB, KAT5, CD40, ITGAL
38	glutamine32	8.2	NCOA2, VIM, LPL, VCL, BMP6, CD14
39	doxorubicin32 34 9 9	11.1	VIM, BMP6, PARP1, BCL2L1, CD40, ITGAL
40	pdtc32	8.1	VCAM1, BIRC5, PARP1, BCL2, BCL2L1, JUN
41	testosterone32 9 18 9	10.9	NCOA2, VIM, LPL, VCAM1, VCL, RARA
42	lactacystin32	7.7	NCOA2, MYC, BIRC5, PARP1, BCL2, BCL2L1
43	atp32	7.7	PIM1, VIM, VCL, LIF, BIRC5, PARP1
44	mg 13232 42	8.7	NCOA2, MYC, RARA, BIRC5, PARP1, BCL2L1
45	etoposide32 42 9 9	10.3	MYC, RARA, BIRC5, PARP1, BCL2, BCL2L1
46	phosphatidylinositol32	7.2	VCAM1, VCL, MYC, BMP6, RARA, LIF
47	resveratrol32 9 18 9	9.7	VEGFA, BIRC5, PARP1, BCL2, BCL2L1, BAX
48	paclitaxel32 34 9 9	8.2	VIM, VEGFA, MYC, BMP6, RARA, LIF
49	cisplatin32 34 9 9	8.0	VEGFA, MYC, BMP6, LIF, BIRC5, PARP1
50	dexamethasone32 42 34 9 9	8.0	NCOA2, SELP, SERPINB2, VIM, VEGFA, LPL

Cellular components related to monocytic leukemia according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	histone acetyltransferase complex	GO:000123	10.1	EP300, CREBBP, KAT8, KAT7
2	Bcl-2 family protein complex	GO:097136	10.0	MCL1, BAX, BCL2L1
3	external side of plasma membrane	GO:009897	9.9	ADA, CXCL12, TLR4, CTSB, TNF, IFNG
4	integral to plasma membrane	GO:005887	9.8	OLR1, LTB4R, ABCC1, TLR4, THBD, CSF1R
5	cell surface	GO:009986	8.9	TREML1, TNF, TNFRSF1A, ABCB1, THBD, CSF1R
6	nucleoplasm	GO:005654	8.8	CASP3, TP53, PPARG, CREBBP, WT1, EGR1
7	mitochondrion	GO:005739	8.6	TRIM39, TP53, CTSB, CRAT, ABL1, PSMA6
8	nucleolus	GO:005730	8.3	WT1, RPP21, TP53, CASP8, CASP3, ABCC1
9	extracellular region	GO:005576	7.9	CASP1, HSPG2, IFNG, IFNB1, CCL3, TNFRSF1A
10	plasma membrane	GO:005886	7.9	CYSLTR1, TNFSF13B, TNFRSF1A, TNF, TREML1, TREML2
11	cytosol	GO:005829	7.1	TRIM39, AIFM1, CASP8, CAB39L, CASP1, CASP3
12	extracellular space	GO:005615	7.0	ADA, F3, HSPG2, TNF, TNFRSF1A, TNFSF13B
13	nucleus	GO:005634	5.7	HOXA9, AIFM1, TP53, TNFRSF1A, PTGS2, CYCS
14	cytoplasm	GO:005737	5.1	PTGS2, TP53, CASP8, CASP3, HSPA4, HSPB1

Biological processes related to monocytic leukemia according to GeneDecks:

(show top 50)    (show all 86)

id	Name	GO ID	Score	Top Affiliating Genes
1	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.7	JUN, CD14, MAPK8, MAPKAPK2, MAPK10, MAPK1
2	toll-like receptor 3 signaling pathway	GO:034138	10.7	MAPKAPK2, JUN, CD14, FOS, MAPK8, MAPK10
3	histone acetylation	GO:016573	10.7	KAT6B, KAT8, CREBBP, KAT6A, KAT5
4	Toll signaling pathway	GO:008063	10.6	TLR4, MAPK1, MAPK10, JUN, CD14, MAPK8
5	cellular response to mechanical stimulus	GO:071260	10.6	CASP8, TLR4, CASP1, MAPK8, FAS, IL1B
6	toll-like receptor 4 signaling pathway	GO:034142	10.6	MAPK8, JUN, TLR4, MAPK1, MAPK10, MAPKAPK2
7	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	10.5	MAPK10, MAPK1, JUN, FOS, MAPK8
8	neutrophil chemotaxis	GO:030593	10.5	IL1B, IL8, CCL3, IFNG, CSF3R, CCL2
9	humoral immune response	GO:006959	10.4	IFNB1, IL6, CCL2, IFNG, TNF, LTF
10	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	10.4	IFNG, TNFRSF1A, CD40, LIF
11	toll-like receptor 1 signaling pathway	GO:034130	10.4	JUN, MAPK8, TLR4, MAPK10, MAPKAPK2, MAPK1
12	MAPK cascade	GO:000165	10.4	MYC, IL1B, MAPKAPK2, MAPK1, TNF, CCL2
13	response to mechanical stimulus	GO:009612	10.4	F3, CCL2, JUN, CXCL12, TNF, CTSB
14	toll-like receptor 2 signaling pathway	GO:034134	10.3	MAPK10, FOS, MAPK8, JUN, MAPKAPK2, TLR4
15	release of cytochrome c from mitochondria	GO:001836	10.3	BCL2L1, BAX, JUN, CASP3, TP53, BCL2
16	toll-like receptor signaling pathway	GO:002224	10.3	FOS, JUN, MAPKAPK2, MAPK10, MAPK1, MAPK8
17	aging	GO:007568	10.2	CCL2, FAS, F3, IL1B, JUN, VCAM1
18	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.2	FAS, PPARG, TNF, AIFM1, CASP8, CASP1
19	neuron apoptotic process	GO:051402	10.2	AIFM1, CASP3, BAX, BCL2, TP53, FAS
20	response to gamma radiation	GO:010332	10.1	IL1B, TP53, BAX, BCL2, MYC, CCL2
21	positive regulation of neuron apoptotic process	GO:043525	10.1	FASLG, BAX, JUN, CCL3, CASP3, TNF
22	regulation of apoptotic process	GO:042981	10.1	PSMA6, PSMA2, NME1, CARD16, CTSB, TP53
23	virus-host interaction	GO:019048	10.0	VIM, VCAM1, TP53, CASP8, BAX, KAT5
24	response to glucocorticoid stimulus	GO:051384	10.0	IL1B, IL6, FAS, TNF, PTGS2, CCL2
25	activation of pro-apoptotic gene products	GO:008633	10.0	MYC, CASP8, MAPK8, FAS, FASLG, BAX
26	cellular response to organic substance	GO:071310	10.0	BCL2, BAX, IL1B, CASP3, CASP1
27	innate immune response	GO:045087	10.0	MAPK1, MAPK10, MAPKAPK2, MAPK8, IL1R1, FOS
28	cytokine-mediated signaling pathway	GO:019221	9.9	IFNB1, CSF1R, NUP98, EGR1, TNFRSF1A, IFNG
29	induction of apoptosis	GO:006917	9.9	CEBPB, FASLG, IFNB1, CASP3, CASP1, TNF
30	cellular component movement	GO:006928	9.9	LTB4R, PTGS2, ABI1, HSPB1, IFNG, IL8
31	response to lipopolysaccharide	GO:032496	9.8	ADM, TLR4, PTGS2, TNFRSF1A, CASP8, CASP1
32	positive regulation of transcription, DNA-dependent	GO:045893	9.7	TP53, ID2, IL1B, MLL, FOS, JUN
33	anti-apoptosis	GO:006916	9.7	BIRC5, SERPINB2, HSPB1, F3, CCL2, TNF
34	induction of apoptosis by extracellular signals	GO:008624	9.5	FASLG, FAS, MAPK8, CASP3, TNF, CASP8
35	immune response	GO:006955	9.5	IL1R1, ITGAD, CD1A, LIF, BMP6, IL8
36	induction of apoptosis by intracellular signals	GO:008629	9.5	CASP3, CASP8, BCL2L1, TP53, MAPK8, CDKN1A
37	negative regulation of transcription, DNA-dependent	GO:045892	9.5	WT1, TFAP2A, E2F1, JUN, KAT6B, PPARG
38	inflammatory response	GO:006954	9.5	LTB4R, OLR1, CYSLTR1, PTGS2, TNFRSF1A, CCL3
39	positive regulation of apoptotic process	GO:043065	9.3	FAS, FASLG, BAX, IL1B, ABL1, TLR4
40	response to toxin	GO:009636	9.3	CCL3, FAS, BCL2, BAX, CDKN1A, CASP1
41	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.3	KAT5, FASLG, ID2, TP53, TNF, PPARG
42	response to hypoxia	GO:001666	9.3	VCAM1, BCL2, ADA, IL1B, FAS, CCL2
43	blood coagulation	GO:007596	9.3	ITGAL, TP53, GATA1, SLC7A7, ABL1, OLR1
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	PPARG, TNFRSF1A, TNF, TP53, CBFB, BMP6
45	negative regulation of cell proliferation	GO:008285	9.0	ADM, LIF, JUN, CDKN1A, FLT3, IL1B
46	response to drug	GO:042493	8.9	ABCB1, CCL2, FAS, CDKN1A, JUN, BCL2
47	positive regulation of gene expression	GO:010628	8.9	E2F1, VEGFA, MAPK8, CCL3, TFAP2A, ID2
48	positive regulation of cell proliferation	GO:008284	8.5	TNFSF13B, FASLG, IL6, FLT3, BCL2L1, BIRC5
49	apoptotic process	GO:006915	8.5	BAX, CD14, MLL, IL1B, MCL1, FAS
50	negative regulation of apoptotic process	GO:043066	8.4	MYC, BCL2, BCL2L1, CSF2, CXCL12, VEGFA

Molecular functions related to monocytic leukemia according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	acetyltransferase activity	GO:016407	10.7	EP300, CREBBP, KAT8, KAT6B, KAT6A
2	histone acetyltransferase activity	GO:004402	10.5	EP300, CREBBP, KAT8, KAT7, KAT6B, KAT6A
3	transcription coactivator activity	GO:003713	10.3	TFAP2A, CREBBP, CBFB, JUN, KAT6A, KAT5
4	transcription regulatory region DNA binding	GO:044212	10.0	TFAP2A, WT1, PPARG, TNF, TP53, MLL
5	protease binding	GO:002020	10.0	TNFRSF1A, TNF, TP53, F3, IL1R1, BCL2
6	BH3 domain binding	GO:051434	9.9	MCL1, BAX, BCL2L1, BCL2
7	transcription factor binding	GO:008134	9.8	JUN, TP53, CREBBP, RUNX1, E2F1, EP300
8	sequence-specific DNA binding transcription factor activity	GO:003700	9.8	PPARG, CREBBP, WT1, EGR1, PRDM2, RUNX1
9	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	9.5	GATA1, TFAP2A, WT1, TP53, CEBPB, KLF4
10	identical protein binding	GO:042802	9.3	NME1, TNF, TP53, TRIM39, CASP8, FAS
11	enzyme binding	GO:019899	9.1	SLC25A4, CSF3, PPARG, PTGS2, TP53, HOXA9
12	growth factor activity	GO:008083	8.8	CSF3, CSF2, CSF1, CXCL12, IL6, IL1B
13	cytokine activity	GO:005125	8.6	CSF3, CSF2, CSF1, TNFSF13B, TNF, IFNG
14	protein heterodimerization activity	GO:046982	8.4	ITGAD, ITGAL, MCL1, TP53, LTC4S, RUNX1
15	protein binding	GO:005515	2.9	ID2, TREML1, TP53, TNF, TNFRSF1A, TNFSF13B