Aliases & Classifications for Monogenic Diabetes

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Aliases & Descriptions for Monogenic Diabetes:

Name: Monogenic Diabetes 45

Classifications:



Summaries for Monogenic Diabetes

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NIH Rare Diseases:45 The most common forms of diabetes, type 1 and type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes . environmental factors, such as obesity in the case of type 2 diabetes, also play a part in the development of polygenic forms of diabetes. polygenic forms of diabetes often run in families. doctors diagnose polygenic forms of diabetes by testing blood glucose in individuals with risk factors or symptoms of diabetes . some rare forms of diabetes result from mutations in a single gene and are called monogenic . monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people . in some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously . most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy . as a result, monogenic diabetes can easily be mistaken for type 1 diabetes . last updated: 9/23/2011

MalaCards based summary: Monogenic Diabetes is related to obesity and diabetes mellitus, permanent neonatal. An important gene associated with Monogenic Diabetes is HNF4A (Hepatocyte Nuclear Factor 4 Alpha), and among its related pathways are Dichloroethylene metabolism and Disorders of transmembrane transporters. Affiliated tissues include testes, pancreas and adipocyte, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Related Diseases for Monogenic Diabetes

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Graphical network of the top 20 diseases related to Monogenic Diabetes:



Diseases related to monogenic diabetes

Symptoms for Monogenic Diabetes

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Drugs & Therapeutics for Monogenic Diabetes

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Drugs for Monogenic Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlimepirideapprovedPhase 2, Phase 322193479-97-13476
Synonyms:
1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea
1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea
3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
64598P
93479-97-1
AB00513874
AC-476
AC1L1G0T
Amarel
Amaryl
Amaryl (TN)
Amaryl, Glista OD, Glimepiride
Avaglim
BPBio1_000751
BRD-K34776109-001-03-4
BRD-K42693031-001-01-8
BRN 5365754
BSPBio_000681
Bio-0049
C07669
C24H34N4O5S
CAS-93479-97-1
CCRIS 7083
CHEBI:5383
CHEMBL1481
CID3476
CPD000466368
D00593
DB00222
Endial
G2295_SIGMA
Glimepirid
Glimepirida
Glimepirida [Spanish]
Glimepiride
Glimepiride (JAN/USP/INN)
Glimepiride [USAN:BAN:INN]
Glimepiridum
 
Glimepiridum [Latin]
Glimepride
Glimer
Glimépiride
Glymepirid
HMS1570C03
HMS2052L03
HMS2090K18
HOE 490
Hoe-490
I06-0029
I06-2285
LS-136752
MLS000759495
MLS001076674
MLS001401419
MolPort-003-847-587
MolPort-003-987-461
MolPort-005-941-721
NCGC00016960-01
NCGC00161404-01
NCGC00161404-02
NCGC00181757-01
Novo-glimepiride
Oprea1_382896
PMS-glimepiride
Prestwick0_000651
Prestwick1_000651
Prestwick2_000651
Prestwick3_000651
Ratio-glimepiride
Roname
S1344_Selleck
SAM001246710
SMR000466368
SPBio_002602
Sandoz glimepiride
Solosa
TL8005924
UNII-6KY687524K
ZINC00537791
glimepiride
2
LiraglutideapprovedPhase 2, Phase 3278204656-20-2
Synonyms:
204656-20-2
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
C439759
Liraglutida
Liraglutida [INN-Spanish]
Liraglutide
Liraglutide [USAN:INN]
Liraglutidum
Liraglutidum [INN-Latin]
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
 
NN 2211
NN-2211
NN2211
NNC 90-1170
N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptide
N²⁶-(hexadecanoyl-gamma-glutamyle)-[34-arginine]GLP-1-(7-37)-peptide
Saxenda
UNII-839I73S42A
Victoza
nn 2211
nn2211
victoza
3Immunologic FactorsPhase 2, Phase 318483
4Immunosuppressive AgentsPhase 2, Phase 310422
5IncretinsPhase 2, Phase 3, Phase 11326
6Hypoglycemic AgentsPhase 2, Phase 34503
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 3, Phase 19988
8Glucagon-Like Peptide 1Phase 2, Phase 3, Phase 1620
9Anti-Arrhythmia AgentsPhase 2, Phase 32371
10Hormone AntagonistsPhase 2, Phase 3, Phase 110002
11HormonesPhase 2, Phase 3, Phase 111748
12Insulin, Globin ZincPhase 14278
13insulinPhase 14278
14glucagonPhase 1379
15Gastrointestinal AgentsPhase 16401
16
Insulin Glargineapproved495160337-95-1
Synonyms:
Insulin Glargine (rDNA origin)
 
Lantus
Lantus Solostar
17
Insulin Lisproapproved222133107-64-9
Synonyms:
Humalog
Humalog Cartridge
Humalog KwikPen
Humalog Mix50/50
 
Humalog Mix50/50 KwikPen
Humalog Mix75/25
Humalog Mix75/25 KwikPen
Humalog Pen
Insulin Lispro Recombinant
18
Insulin, isophaneapproved23053027-39-7
Synonyms:
Humulin N
 
Isophane Insulin
NPH Insulin
Novolin N
19
Zincapproved14777440-66-623994, 32051
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
20
Insulin Detemirapproved189169148-63-45311023
Synonyms:
Insulin detemir
Insulin detemir recombinant
Levemir
 
Levemir flexpen
Levemir innolet
Levemir penfill
NN-304
21
Insulin Aspartapproved423116094-23-616132418
Synonyms:
(AspB28)-human insulin
1024611-56-0
116094-23-6
139532-40-4
28(sup B)-L-Aspartic acid-insulin (human)
877034-90-7
AspB28-insulin (human)
Aspart
Aspart Insulin
Aspart insulin
B28-Asp-insulin
B28-Aspart-Insulin
INA-X 14
 
INA-X14
Insulin X14
Insulin aspart
Insulin aspart [USAN]
Insulin, Asp(B28)
LS-185932
NovoLog
NovoMix 30
NovoRapid
NovoRapid 30 Mix
Novolog
Novolog Mix 70/30
Novolog mix 70/30
UNII-D933668QVX
22Antibodies4477
23Immunoglobulins4477
24Autoantibodies117
25Isophane Insulin, Human141
26Isophane insulin, beef141
27arginineNutraceutical364

Interventional clinical trials:

idNameStatusNCT IDPhase
1The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)CompletedNCT01610934Phase 2, Phase 3
2Incretin Regulation of Insulin Secretion in Monogenic DiabetesRecruitingNCT01795144Phase 1
3Predisposition Genes in Monogenic Diabetes (DIAMONO)CompletedNCT02634229
4Using Pharmacogenetics to Improve Treatment in Early-onset DiabetesCompletedNCT01238380
5Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and ObesityCompletedNCT01784289
6Identification and Characterization of Monogenic DiabetesRecruitingNCT01481623
7The Verona Newly Diagnosed Type 2 Diabetes StudyRecruitingNCT01526720
8GENetic & Immunologic Abnomalies in Systemic Lupus ErythematosusRecruitingNCT01992666
9Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic DiabetesNot yet recruitingNCT02556840

Search NIH Clinical Center for Monogenic Diabetes

Genetic Tests for Monogenic Diabetes

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Anatomical Context for Monogenic Diabetes

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MalaCards organs/tissues related to Monogenic Diabetes:

33
Testes, Pancreas, Adipocyte, Heart, Prostate, Monocytes, Spleen

Animal Models for Monogenic Diabetes or affiliated genes

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MGI Mouse Phenotypes related to Monogenic Diabetes:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9CEL, GCK, HNF1A, HNF4A, INS, PDX1
2MP:00053818.7CEL, HNF1A, INS, PDX1, SLC19A2
3MP:00053758.5ADPGK, CEL, HNF1A, INS, KCNJ11
4MP:00053678.5GCK, HNF1A, INS, MAFA, PDX1
5MP:00030128.0ABCC8, HNF1A, INS, KCNJ11, MAFA, PDX1
6MP:00053797.3ABCC8, GCK, HNF1A, INS, KCNJ11, MAFA
7MP:00053786.2ADPGK, CEL, GCK, HNF1A, HNF4A, IAPP
8MP:00053764.9ABCC8, ADPGK, CEL, GCK, HNF1A, HNF4A

Publications for Monogenic Diabetes

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Articles related to Monogenic Diabetes:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Huge Pseudoaneurysm and Cystic Adventitial Disease From Popliteal Artery Entrapment. (26416631)
2015
2
Heart lesion after the first attack of the rheumatic Fever 22 years experience in single centre. (25870479)
2015
3
Eggerthella lenta bacteraemia complicated by spondylodiscitis, psoas abscess and meningitis. (24430458)
2014
4
A CLN8 nonsense mutation in the whole genome sequence of a mixed breed dog with neuronal ceroid lipofuscinosis and Australian Shepherd ancestry. (24953404)
2014
5
Asymptomatic lymphangioma involving the spleen and mediastinum in adults. (23702506)
2013
6
Metatarsus adductus: development of a non-surgical treatment pathway. (23647850)
2013
7
Split-hand plus sign in ALS: differential involvement of the flexor pollicis longus and intrinsic hand muscles. (23121291)
2013
8
Intakes of nutrients in Italian children with celiac disease and the role of commercially available gluten-free products. (23252793)
2013
9
The non-canonical II_B kinases IKKI/ and TBK1 as potential targets for the development of novel therapeutic drugs. (23157677)
2013
10
A duodenal mass and acute pancreatitis. (24226730)
2013
11
Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus. (22763415)
2012
12
Contribution of VKORC1 and CYP2C9 polymorphisms in the interethnic variability of warfarin dose in Malaysian populations. (21110192)
2011
13
Significant association between common polymorphisms in the aromatase gene CYP19A1 and bone mineral density in postmenopausal women. (21952832)
2011
14
Knowledge and screening of testicular cancer in the French Armed Forces: a prospective study. (22128657)
2011
15
Distinguishing Crohn's disease from intestinal tuberculosis--a prospective study. (22332336)
2011
16
Riles type 1A common carotid artery occlusion diagnosed by specific external carotid artery Doppler waveform pattern in carotid ultrasonography. Case report. (21206185)
2010
17
PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease. (19602051)
2009
18
Botulinum toxin A injections for the treatment of Schwartz-Jampel syndrome: a case series. (19168812)
2009
19
Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde. (18661355)
2008
20
Assessment of hemorheological deformability of human red cells exposed to tert-butyl hydroperoxide, verapamil and ascorbate by ektacytometer]. (18971612)
2008
21
Atypical scrapie in a sheep in a closed UK flock with endemic classical natural scrapie. (18515761)
2008
22
Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. (17483322)
2007
23
A novel adjustable pulmonary artery banding system for hypoplastic left heart syndrome. (17992303)
2007
24
Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004. (16896144)
2006
25
Echocardiography in a horse with cor pulmonale from recurrent airway obstruction. (16734111)
2006
26
Serotonin transporter polymorphisms and side effects in antidepressant therapy--a pilot study. (16515395)
2006
27
Meckel's diverticulum bleeding detected by capsule endoscopy. (16564878)
2006
28
Chronic gastric electrical stimulation for gastroparesis reduces the use of prokinetic and/or antiemetic medications and the need for hospitalizations. (16047482)
2005
29
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5). (15878659)
2005
30
Ezetimibe: new preparation. A cholesterol-lowering drug with no clinical advantage. (15499698)
2004
31
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. (15540117)
2004
32
Germinal centers regulate human Th2 development. (12902463)
2003
33
Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. (12401749)
2002
34
Endourologic reconstruction of post-traumatic obliterated urethral stricture in a young female: a point of technique. (11744490)
2001
35
Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area. (10223957)
1999
36
Periarticular corticosteroid treatment of the sacroiliac joint in patients with seronegative spondylarthropathy. (10084038)
1999
37
Buffering capacity of coal and its acid-soluble Fe2+ content: possible role in coal workers' pneumoconiosis. (9671534)
1998
38
Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP. (7556414)
1995
39
Production and utilization of detyrosinated tubulin in developing Artemia larvae: evidence for a tubulin-reactive carboxypeptidase. (8714688)
1995
40
Modulation of nerve and glial function by adenosine--role in the development of ischemic damage. (7531656)
1994
41
Expression and localization of dystrophin in human cardiac Purkinje fibers. (1617767)
1992
42
Molecular analysis of HLA-DRB1*08/12 alleles: identification of two additional alleles. (1399719)
1992
43
Differential inhibition of rat hepatic glutathione S-transferase isoenzymes in the course of fascioliasis. (2052025)
1991
44
Heel spur syndrome. Pathomechanics and nonsurgical treatment. Biomechanics Graduate Research Group for 1988. (1999801)
1991
45
Class II major histocompatibility complex antigen expression on unstimulated and gamma-interferon stimulated monocytes from patients with multiple sclerosis, rheumatoid arthritis and normal controls. (1777559)
1991
46
GP37 is different from filaggrin. (2366003)
1990
47
D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoid arthritis. Report of a case and review of the literature. (2523911)
1989
48
Primary angle closure glaucoma: extracapsular cataract extraction or filtering procedure? (3229905)
1988
49
A case of carcinoma in intralobar pulmonary sequestration. (3238668)
1988
50
The P 37/24 modification of the infectious bovine rhinotracheitis virus-serum neutralization test. (217258)
1978

Variations for Monogenic Diabetes

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Expression for genes affiliated with Monogenic Diabetes

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Search GEO for disease gene expression data for Monogenic Diabetes.

Pathways for genes affiliated with Monogenic Diabetes

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Pathways related to Monogenic Diabetes according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9HNF1A, HNF4A
2
Show member pathways
9.3ABCC8, GCK, KCNJ11
3
Show member pathways
9.3ABCC8, INS, KCNJ11
4
Show member pathways
9.0GCK, HNF1A, HNF4A, INS, PDX1
5
Show member pathways
8.6ABCC8, GCK, INS, KCNJ11, PDX1
68.1ABCC8, GCK, HNF1A, HNF4A, INS, KCNJ11
7
Show member pathways
7.5GCK, HNF1A, HNF4A, IAPP, INS, MAFA
8
Show member pathways
7.5GCK, HNF1A, HNF4A, IAPP, INS, MAFA
9
Show member pathways
7.3ABCC8, GCK, HNF1A, HNF4A, INS, KCNJ11

GO Terms for genes affiliated with Monogenic Diabetes

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Biological processes related to Monogenic Diabetes according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolytic processGO:004582110.5GCK, INS
2positive regulation of glycogen biosynthetic processGO:004572510.4GCK, INS
3negative regulation of gluconeogenesisGO:004572110.4GCK, INS
4detection of glucoseGO:005159410.3GCK, PDX1
5glucose transportGO:001575810.3GCK, INS
6response to glucoseGO:00097499.9GCK, HNF4A, PDX1
7glucose homeostasisGO:00425939.5GCK, HNF1A, HNF4A, PDX1
8glucose metabolic processGO:00060069.2ADPGK, INS, KCNJ11
9regulation of insulin secretionGO:00507969.1ABCC8, GCK, HNF1A, HNF4A, INS
10endocrine pancreas developmentGO:00310189.1HNF1A, HNF4A, IAPP, INS, PDX1
11regulation of transcription, DNA-templatedGO:00063558.1HNF1A, HNF4A, INS, MAFA, PDX1

Molecular functions related to Monogenic Diabetes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-activated inward rectifier potassium channel activityGO:001527210.0ABCC8, KCNJ11
2RNA polymerase II core promoter sequence-specific DNA bindingGO:00009799.9HNF1A, HNF4A

Sources for Monogenic Diabetes

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet