MCID: MNG006
MIFTS: 35

Monogenic Diabetes malady

Category: Rare diseases

Aliases & Classifications for Monogenic Diabetes

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Aliases & Descriptions for Monogenic Diabetes:

Name: Monogenic Diabetes 48

Classifications:



Summaries for Monogenic Diabetes

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NIH Rare Diseases:48 The most common forms of diabetes, type 1 and type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes . environmental factors, such as obesity in the case of type 2 diabetes, also play a part in the development of polygenic forms of diabetes. polygenic forms of diabetes often run in families. doctors diagnose polygenic forms of diabetes by testing blood glucose in individuals with risk factors or symptoms of diabetes . some rare forms of diabetes result from mutations in a single gene and are called monogenic . monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people . in some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously . most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy . as a result, monogenic diabetes can easily be mistaken for type 1 diabetes . last updated: 9/23/2011

MalaCards based summary: Monogenic Diabetes is related to diabetes mellitus, permanent neonatal and maturity-onset diabetes of the young. An important gene associated with Monogenic Diabetes is GCK (Glucokinase), and among its related pathways are Dichloroethylene metabolism and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testes and pancreas, and related mouse phenotypes are adipose tissue and no phenotypic analysis.

Related Diseases for Monogenic Diabetes

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Diseases related to Monogenic Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus, permanent neonatal11.5
2maturity-onset diabetes of the young10.8
3diaphanospondylodysostosis10.2ABCC8, GCK
4pleuropulmonary blastoma10.2HNF1A, INS
5biliary cirrhosis, primary, 510.2HNF1B, HNF4A
6noonan syndrome 310.2ABCC8, KCNJ11
7ritscher-schinzel syndrome 210.1ABCC8, KCNJ11
8alopecia-mental retardation syndrome 210.1ABCC8, INS
9nosophobia10.1ABCC8, GCK, KCNJ11
10orbital granuloma10.1GCK, PDX1
11fanconi anemia, complementation group f10.1ABCC8, KCNJ11
12autoimmune disease 110.1ABCC8, INS, KCNJ11
13deafness, autosomal recessive 6610.1ABCC8, INS, KCNJ11
14chondroma10.1ABCC8, INS, KCNJ11
15hemorrhagic fever10.1ABCC8, KCNJ11
16labyrinthine unilateral reactive loss10.0ABCC8, GCK, INS, KCNJ11
17antidepressant type abuse10.0GCK, HNF1A, INS, KCNJ11
18neurogenic arthropathy10.0ABCC8, GCK, INS, KCNJ11
19chudley-mccullough syndrome9.9IAPP, INS
20maturity-onset diabetes of the young, type 139.9ABCC8, GCK, HNF4A, INS, KCNJ11
21diabetic cataract9.9ABCC8, GCK, HNF4A, INS, KCNJ11
22exostosis9.9ABCC8, GCK, HNF4A, INS, KCNJ11
23non-syndromic intellectual disability9.9ABCC8, GCK, INS, KCNJ11, PDX1
24gestational diabetes9.9
25peroneal neuropathy9.8ABCC8, GCK, IAPP, INS, KCNJ11
26body dysmorphic disorder9.8ABCC8, GCK, IAPP, INS, KCNJ11
27ischemic heart disease9.8ABCC8, GCK, IAPP, INS, PDX1
28distal muscular dystrophy9.7ABCC8, GCK, HNF1B, INS, KCNJ11, PDX1
29focal segmental glomerulosclerosis 89.6ABCC8, GCK, INS, KCNJ11, PDX1, SLC19A2
30obesity9.6
31megaloblastic anemia9.6
32hyperinsulinism9.6
33hyperglycemia9.6
34pancreatitis9.6
35hypopituitarism9.6
36hypoglycemia9.6
37renal dysplasia9.6
38brain stem glioma9.6ABCC8, GCK, HNF1A, IAPP, INS, KCNJ11
39maturity-onset diabetes of the young 69.3ABCC8, GCK, HNF1A, HNF1B, HNF4A, IAPP
40diabetes mellitus, insulin-dependent, 209.2GCK, HNF1A, HNF1B, HNF4A, IAPP, INS
41congenital stationary night blindness9.1ABCC8, CEL, GCK, HNF1A, HNF1B, HNF4A
42mosaic trisomy 138.4ABCC8, ADPGK, CEL, GCK, HNF1A, HNF1B

Graphical network of the top 20 diseases related to Monogenic Diabetes:



Diseases related to monogenic diabetes

Symptoms & Phenotypes for Monogenic Diabetes

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MGI Mouse Phenotypes related to Monogenic Diabetes according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1ADPGK, CEL, HNF1A, INS, KCNJ11
2MP:00030129.0ABCC8, HNF1A, INS, KCNJ11, MAFA, PDX1
3MP:00053708.8CEL, GCK, HNF1A, HNF1B, HNF4A, INS
4MP:00053678.3GCK, HNF1A, HNF1B, INS, MAFA, PDX1
5MP:00053797.9ABCC8, GCK, HNF1A, HNF1B, INS, KCNJ11
6MP:00053786.8ADPGK, CEL, GCK, HNF1A, HNF1B, HNF4A
7MP:00053765.7ABCC8, ADPGK, CEL, GCK, HNF1A, HNF1B

Drugs & Therapeutics for Monogenic Diabetes

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Drugs for Monogenic Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GlimepirideapprovedPhase 2, Phase 323493479-97-13476
Synonyms:
1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea
1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea
3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
64598P
93479-97-1
AB00513874
AC-476
AC1L1G0T
Amarel
Amaryl
Amaryl (TN)
Amaryl, Glista OD, Glimepiride
Avaglim
BPBio1_000751
BRD-K34776109-001-03-4
BRD-K42693031-001-01-8
BRN 5365754
BSPBio_000681
Bio-0049
C07669
C24H34N4O5S
CAS-93479-97-1
CCRIS 7083
CHEBI:5383
CHEMBL1481
CID3476
CPD000466368
D00593
DB00222
Endial
G2295_SIGMA
Glimepirid
Glimepirida
Glimepirida [Spanish]
Glimepiride (JAN/USP/INN)
Glimepiride [USAN:BAN:INN]
Glimepiridum
Glimepiridum [Latin]
 
Glimepride
Glimer
Glimépiride
Glymepirid
HMS1570C03
HMS2052L03
HMS2090K18
HOE 490
Hoe-490
I06-0029
I06-2285
LS-136752
MLS000759495
MLS001076674
MLS001401419
MolPort-003-847-587
MolPort-003-987-461
MolPort-005-941-721
NCGC00016960-01
NCGC00161404-01
NCGC00161404-02
NCGC00181757-01
Novo-glimepiride
Oprea1_382896
PMS-glimepiride
Prestwick0_000651
Prestwick1_000651
Prestwick2_000651
Prestwick3_000651
Ratio-glimepiride
Roname
S1344_Selleck
SAM001246710
SMR000466368
SPBio_002602
Sandoz glimepiride
Solosa
TL8005924
UNII-6KY687524K
ZINC00537791
glimepiride
2
LiraglutideapprovedPhase 2, Phase 3329204656-20-2
Synonyms:
204656-20-2
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
C439759
Liraglutida
Liraglutida [INN-Spanish]
Liraglutide
Liraglutide [USAN:INN]
Liraglutide recombinant
Liraglutidum
Liraglutidum [INN-Latin]
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide
 
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
NN 2211
NN-2211
NN2211
NNC 90-1170
N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptide
N²⁶-(hexadecanoyl-gamma-glutamyle)-[34-arginine]GLP-1-(7-37)-peptide
UNII-839I73S42A
Victoza
nn 2211
nn2211
victoza
3IncretinsPhase 2, Phase 3, Phase 11579
4Anti-Arrhythmia AgentsPhase 2, Phase 33093
5Glucagon-Like Peptide 1Phase 2, Phase 3, Phase 1715
6Immunosuppressive AgentsPhase 2, Phase 313086
7Hypoglycemic AgentsPhase 2, Phase 35896
8Hormone AntagonistsPhase 2, Phase 3, Phase 113180
9HormonesPhase 2, Phase 3, Phase 114415
10Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 3, Phase 113168
11Insulin, Globin ZincPhase 14645
12insulinPhase 14646
13Gastrointestinal AgentsPhase 18402
14glucagonPhase 1478
15
Insulin Aspartapproved442116094-23-616132418
Synonyms:
(AspB28)-human insulin
1024611-56-0
116094-23-6
139532-40-4
28(sup B)-L-Aspartic acid-insulin (human)
877034-90-7
AspB28-insulin (human)
Aspart
Aspart Insulin
Aspart insulin
B28-Asp-insulin
B28-Aspart-Insulin
INA-X 14
 
INA-X14
Insulin X14
Insulin aspart
Insulin aspart [USAN]
Insulin aspart protamine recombinant
Insulin aspart recombinant
Insulin, Asp(B28)
LS-185932
NovoLog
NovoMix 30
NovoRapid
NovoRapid 30 Mix
Novolog mix 70/30
UNII-D933668QVX
16
Insulin Detemirapproved195169148-63-45311023
Synonyms:
Detemir
 
Insulin detemir recombinant
Insulin,detemir,human
17
Insulin Lisproapproved240133107-64-9
Synonyms:
Insulin lispro (genetical recombination)
Insulin lispro (rDNA origin)
Insulin lispro protamine
 
Insulin lispro protamine recombinant
Insulin lispro recombinant
Insulin,lispro,human/rDNA
Insulin,lispro,protamine/rDNA
18
Zincapproved22967440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
19
Insulin Glargineapproved528160337-95-1
Synonyms:
 
Insulin Glargine (rDNA origin)
Insulin glargine recombinant
20
Adenosineapproved, investigational41958-61-760961
Synonyms:
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
1odi
2fqy
2gl0
30143-02-3
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
A0152
A4036_SIGMA
A9251_SIGMA
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ADN
AI3-52413
Ade-Rib
Ade-rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine deoxyribonucleoside
Adenine nucleoside
Adenine riboside
Adenine-9-beta-D-ribofuranoside
Adenine-9beta-D-Ribofuranoside
Adenine-9beta-delta-Ribofuranoside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine, homopolymer
Adenosinum
Adensoine
Adenyldeoxyriboside
Ado
Adénosine
BB_NC-0565
BSPBio_001796
Bio1_000437
 
Bio1_000926
Bio1_001415
Boniton
C00212
CCRIS 2557
CHEBI:16335
CHEMBL477
CID60961
Caswell No. 010B
D000241
D00045
DB00640
Deoxyadenosine
Desoxyadenosine
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
FT-0082881
HMS1920A13
HMS2091G13
KBio3_001296
LS-15085
MEDR-640
MLS000069638
MLS002153227
MolPort-001-838-229
Myocol
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NSC 627048
NSC 7652
NSC627048
NSC7652
Nucleocardyl
Pallacor
Polyadenosine
Polyriboadenosine
S1647_Selleck
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
SR 96225
SR-96225
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum3_000288
TL8003749
UNII-K72T3FS567
USAF CB-10
V0098
Vidarabine
ZINC02169830
adenine-D-ribose
adenosine
b-D-Adenosine
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.2007.56-comp13
nchembio.64-comp4
nchembio706-5
21Antibodies6394
22Autoantibodies130
23Immunoglobulins6394
24Insulin, Isophane252
25Isophane insulin, beef151
26Isophane Insulin, Human151
27Peripheral Nervous System Agents23689
28Neurotransmitter Agents18340
29Analgesics11733
30Vasodilator Agents3543
31arginineNutraceutical425

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)CompletedNCT01610934Phase 2, Phase 3
2Incretin Regulation of Insulin Secretion in Monogenic DiabetesCompletedNCT01795144Phase 1
3Identification and Characterization of Monogenic DiabetesUnknown statusNCT01481623
4Predisposition Genes in Monogenic Diabetes (DIAMONO)CompletedNCT02634229
5Using Pharmacogenetics to Improve Treatment in Early-onset DiabetesCompletedNCT01238380
6Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and ObesityCompletedNCT01784289
7GENetic & Immunologic Abnomalies in Systemic Lupus ErythematosusCompletedNCT01992666
8Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic DiabetesRecruitingNCT02556840
9The Verona Newly Diagnosed Type 2 Diabetes StudyRecruitingNCT01526720
10Wolfram Syndrome International Registry and Clinical StudyRecruitingNCT02841553
11Gene Study for Infantile Onset DiabetesNot yet recruitingNCT03169413

Search NIH Clinical Center for Monogenic Diabetes

Genetic Tests for Monogenic Diabetes

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Anatomical Context for Monogenic Diabetes

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MalaCards organs/tissues related to Monogenic Diabetes:

36
Testes, Pancreas

Publications for Monogenic Diabetes

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Articles related to Monogenic Diabetes:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Practical Aspects of Monogenic Diabetes: A Clinical Point of View. (26897468)
2016
2
First 2 cases with thiamine-responsive megaloblastic anemia in the Czech Republic, a rare form of monogenic diabetes mellitus: a novel mutation in the thiamine transporter SLC19A2 gene-intron 1 mutation c.204+2T>G. (28004468)
2016
3
Comment on Rudland et al. Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c. Diabetes Care 2016;39:50-52. (26696667)
2016
4
Monogenic Diabetes: Not Your "Typical" Diabetes. (27491106)
2016
5
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. (27035557)
2016
6
Treating young adults with type 2 diabetes or monogenic diabetes. (27432078)
2016
7
GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated. (27106716)
2016
8
The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes. (27486234)
2016
9
Structure - Function studies of HNF1A (MODY3) gene mutations in South Indian patients with monogenic diabetes. (26853433)
2016
10
Monogenic diabetes: Implementation of translational genomic research towards precision medicine. (27390143)
2016
11
Diagnosis of monogenic diabetes: 10-Year experience in a large multi-ethnic diabetes center. (27330718)
2016
12
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes. (27271189)
2016
13
A preliminary study to evaluate the strategy of combining clinical criteria and next generation sequencing (NGS) for the identification of monogenic diabetes among multi-ethnic Asians. (27420379)
2016
14
Monogenic diabetes and pregnancy. (27512465)
2015
15
What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? (26599467)
2015
16
Monogenic diabetes: the treatment options. (25773279)
2015
17
Molecular genetic testing of patients with monogenic diabetes and hyperinsulinism. (25555642)
2015
18
New insights from monogenic diabetes for "common" type 2 diabetes. (26300908)
2015
19
Genetic testing for monogenic diabetes using targeted next-generation sequencing in the MODY cohort from Poland. (26552609)
2015
20
Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Cohort: New Pregnancy Screening Criteria and Utility of HbA1c. (26109503)
2015
21
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds. (26043405)
2015
22
An online monogenic diabetes discussion group: supporting families and fueling new research. (26184072)
2015
23
Personalized Medicine: Monogenic Diabetes. (26390534)
2015
24
Many faces of monogenic diabetes. (24843749)
2014
25
Population-based estimates for double diabetes amongst people with glucokinase monogenic diabetes, GCK-MODY. (24660669)
2014
26
The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort. (24550216)
2014
27
Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model. (24476040)
2014
28
The variable faces of monogenic diabetes. (24330066)
2014
29
Functional characterization of two novel splicing mutations in glucokinase gene in monogenic diabetes MODY2]. (25850297)
2014
30
Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes. (24430318)
2014
31
Identifying monogenic diabetes in a pediatric cohort with presumed type 1 diabetes. (25082184)
2014
32
Phenotypic heterogeneity in monogenic diabetes: The clinical and diagnostic utility of a gene panel-based next-generation sequencing approach. (25306193)
2014
33
Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes. (25136813)
2014
34
The diagnosis and management of monogenic diabetes in children and adolescents. (25182307)
2014
35
Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. (23624530)
2013
36
Monogenic diabetes: a diagnostic algorithm for clinicians. (24705260)
2013
37
Development of an economic evaluation of diagnostic strategies: the case of monogenic diabetes. (23793674)
2013
38
Monogenic diabetes: old and new approaches to diagnosis. (23760703)
2013
39
Family history in the diagnosis of monogenic diabetes "leads and misleads". (24121389)
2013
40
Positivity for islet cell autoantibodies in patients with monogenic diabetes is associated with later diabetes onset and higher HbA1c level. (24102923)
2013
41
Improved genetic testing for monogenic diabetes using targeted next-generation sequencing. (23771172)
2013
42
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. (22498247)
2012
43
Doubling the referral rate of monogenic diabetes through a nationwide information campaign--update on glucokinase gene mutations in a Polish cohort. (22035297)
2012
44
Monogenic diabetes in a family with 2 unknown HNF-4A gene mutations. (21922456)
2012
45
Prevalence of monogenic diabetes amongst Polish children after a nationwide genetic screening campaign. (22782286)
2012
46
Novel glucokinase mutations in patients with monogenic diabetes - clinical outline of GCK-MD and potential for founder effect in Slavic population. (21348868)
2012
47
The role of pancreatic imaging in monogenic diabetes mellitus. (22124438)
2012
48
Monogenic diabetes mellitus due to defects in insulin secretion. (23037711)
2012
49
Paternally inherited proinsulin mutations may result in earlier onset of monogenic diabetes mutation identity effect in monogenic diabetes. (21193618)
2011
50
Genetics in the real world: resources for pediatric nurses using monogenic diabetes as an exemplar. (21930042)
2011

Variations for Monogenic Diabetes

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Expression for genes affiliated with Monogenic Diabetes

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Search GEO for disease gene expression data for Monogenic Diabetes.

Pathways for genes affiliated with Monogenic Diabetes

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GO Terms for genes affiliated with Monogenic Diabetes

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Cellular components related to Monogenic Diabetes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-sensitive potassium channel complexGO:00082829.8ABCC8, KCNJ11

Biological processes related to Monogenic Diabetes according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1glucose transportGO:001575810.7GCK, INS
2negative regulation of gluconeogenesisGO:004572110.7GCK, INS
3positive regulation of glycogen biosynthetic processGO:004572510.7GCK, INS
4cellular glucose homeostasisGO:000167810.6ABCC8, GCK
5detection of glucoseGO:005159410.6GCK, PDX1
6endocrine pancreas developmentGO:003101810.6HNF1A, PDX1
7negative regulation of insulin secretionGO:004667610.6ABCC8, KCNJ11
8positive regulation of transcription initiation from RNA polymerase II promoterGO:006026110.5HNF1A, HNF1B
9regulation of pronephros sizeGO:003556510.5HNF1A, HNF1B
10regulation of Wnt signaling pathwayGO:003011110.5HNF1A, HNF1B
11nitric oxide mediated signal transductionGO:000726310.3MAFA, PDX1
12liver developmentGO:000188910.2HNF1A, HNF1B, PDX1
13glycolytic processGO:000609610.2ADPGK, GCK
14glucose homeostasisGO:00425939.8GCK, HNF1A, HNF4A, INS, PDX1
15regulation of insulin secretionGO:00507969.7ABCC8, GCK, HNF1A, HNF4A, KCNJ11
16response to drugGO:00424939.7ABCC8, HNF1B, KCNJ11, PDX1
17insulin secretionGO:00300739.6HNF1A, HNF1B, MAFA, PDX1
18positive regulation of transcription from RNA polymerase II promoterGO:00459449.3HNF1A, HNF1B, HNF4A, MAFA, PDX1
19positive regulation of transcription, DNA-templatedGO:00458939.3HNF1A, HNF1B, HNF4A, MAFA, PDX1
20response to glucoseGO:00097499.3HNF1A, HNF1B, HNF4A, MAFA, PDX1
21glucose metabolic processGO:00060069.2ADPGK, GCK, INS, KCNJ11, PDX1
22transcription from RNA polymerase II promoterGO:00063669.0HNF1A, HNF4A, MAFA, PDX1

Molecular functions related to Monogenic Diabetes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-activated inward rectifier potassium channel activityGO:001527210.6ABCC8, KCNJ11
2phosphotransferase activity, alcohol group as acceptorGO:001677310.1ADPGK, GCK
3transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370510.1HNF1B, HNF4A, PDX1
4protein heterodimerization activityGO:00469829.6HNF1A, HNF1B, MAFA, PDX1
5sequence-specific DNA bindingGO:00435659.3HNF1A, HNF1B, HNF4A, MAFA, PDX1
6transcription factor activity, sequence-specific DNA bindingGO:00037008.6HNF1A, HNF1B, HNF4A, MAFA, PDX1

Sources for Monogenic Diabetes

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
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46NDF-RT
49NINDS
50Novoseek
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53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet