MCID: MNG004
MIFTS: 27

Monogenic Non-Syndromic Obesity, Autosomal Recessive malady

Metabolic diseases category

Summaries for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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MalaCards: Monogenic Non-Syndromic Obesity, Autosomal Recessive is related to obesity with impaired prohormone processing and severe pre-eclampsia. An important gene associated with Monogenic Non-Syndromic Obesity, Autosomal Recessive is POMC (proopiomelanocortin), and among its related pathways are Insulin Processing and Glycoprotein hormones. The compounds shu 9119 and alpha msh have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

monogenic non-syndromic obesity, autosomal recessive 20


Related Diseases for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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17GeneCards, 18GeneDecks
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Diseases related to Monogenic Non-Syndromic Obesity, Autosomal Recessive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1obesity with impaired prohormone processing10.0PCSK1
2severe pre-eclampsia10.0LEP
3coronary heart disease10.0LEP
4hypoadrenalism10.0POMC
5hypoglycemia10.0POMC
6adrenal carcinoma10.0POMC
7alzheimer's disease10.0PCSK1
8thyroiditis10.0POMC
9craniopharyngioma10.0POMC
10myoma10.0LEPR
11hyperthyroidism10.0PCSK1, LEP
12cushing's syndrome10.0POMC
13asthma10.0POMC
14growth hormone deficiency10.0LEP, POMC
15acth deficiency10.0PCSK1, POMC
16adrenal gland hyperfunction10.0POMC, LEP
17hypertension10.0LEP, POMC
18precocious puberty10.0LEP, POMC
19pheochromocytoma10.0PCSK1, POMC
20hypopituitarism10.0LEP, POMC
21amenorrhea10.0POMC, LEP
22primary hyperoxaluria10.0POMC, LEP
23insulin resistance10.0LEPR, LEP
24bulimia nervosa10.0LEPR, LEP
25addison's disease10.0PCSK1, POMC
26hyperandrogenism10.0LEP, POMC
27morbid obesity10.0LEP, LEPR
28carcinoid syndrome10.0POMC, PCSK1
29eating disorder10.0LEP, LEPR
30gestational diabetes10.0LEP, LEPR
31essential hypertension10.0LEP, LEPR
32congenital heart defect10.0LEP, POMC
33nephrotic syndrome10.0POMC, LEPR
34infertility10.0LEPR, LEP
35fatty liver disease10.0LEP, LEPR
36hypogonadism10.0POMC, PCSK1, LEP
37glucose intolerance10.0LEPR, LEP
38hypothyroidism10.0POMC, LEP, PCSK1
39hyperinsulinism10.0LEP, LEPR
40kallmann syndrome10.0LEP, LEPR, PCSK1
41osteoporosis10.0LEP, LEPR
42type 2 diabetes mellitus10.0LEPR, PCSK1, LEP
43acromegaly10.0POMC, LEP, LEPR
44metabolic syndrome x10.0LEPR, LEP, POMC
45pituitary tumors10.0POMC, LEPR, PCSK1
46diabetes mellitus10.0LEP, LEPR, POMC
47adenoma10.0PCSK1, LEPR, POMC
48anorexia nervosa10.0POMC, LEP, LEPR
49polycystic ovary syndrome10.0LEP, POMC, LEPR
50hyperglycemia10.0LEPR, POMC, LEP

Graphical network of the top 20 diseases related to Monogenic Non-Syndromic Obesity, Autosomal Recessive:



Diseases related to monogenic non-syndromic obesity, autosomal recessive

Clinical Features for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Drugs & Therapeutics for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Genetic tests related to Monogenic Non-Syndromic Obesity, Autosomal Recessive:

id Genetic test Affiliating Genes
1 Monogenic Non-Syndromic Obesity, Autosomal Recessive20 POMC

Anatomical Context for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Animal Models for Monogenic Non-Syndromic Obesity, Autosomal Recessive or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Monogenic Non-Syndromic Obesity, Autosomal Recessive:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6LEPR, LEP, POMC
2MP:00053708.6LEPR, LEP, POMC
3MP:00053758.2LEPR, LEP, PCSK1, POMC
4MP:00053798.2POMC, PCSK1, LEP, LEPR
5MP:00053858.2POMC, PCSK1, LEP, LEPR
6MP:00053978.1LEPR, LEP, PCSK1, POMC
7MP:00053868.1POMC, PCSK1, LEP, LEPR
8MP:00053878.1POMC, PCSK1, LEP, LEPR
9MP:00053847.9POMC, PCSK1, LEP, LEPR
10MP:00053787.7LEPR, LEP, PCSK1, POMC

Publications for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Genetic Variations for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Expression for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Pathways for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Monogenic Non-Syndromic Obesity, Autosomal Recessive according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3PCSK1, POMC
2
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9.3PCSK1, POMC
39.1LEPR, LEP
4
Development Prolactin receptor signaling
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9.1LEPR, LEP
59.1LEPR, LEP
6
Development Leptin signaling via PI3K-dependent pathway
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9.1LEP, LEPR
79.1LEPR, LEP
88.6POMC, LEP, LEPR
9
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8.6POMC, LEP, LEPR
10
Development Leptin signaling via JAK/STAT and MAPK cascades
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8.6LEPR, LEP, POMC

Compounds for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Monogenic Non-Syndromic Obesity, Autosomal Recessive according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1shu 911944 5910.8LEP, POMC
2alpha msh449.8POMC, LEP
3megestrol acetate449.8LEP, POMC
4topiramate44 11 2411.8LEP, POMC
5thiopental44 1110.8LEP, POMC
6fenfluramine28 44 1111.8POMC, LEP
7cortisone44 2410.8LEP, POMC
8budesonide44 49 1111.8POMC, LEP
911beta-hydroxysteroid449.7LEP, POMC
10naloxone44 49 28 1112.7LEP, POMC
11dehydroepiandrosterone sulfate449.7POMC, LEP
12peptidylglycine449.7PCSK1, POMC
13clonidine44 28 1111.7LEP, POMC
14oxyntomodulin44 5910.7LEP, PCSK1
15metformin44 49 1111.7LEP, POMC
16ganciclovir44 1110.6POMC, LEP
17dhea449.6POMC, LEP
18lep (116-130) (mouse)599.6LEPR, LEP
19c-peptide449.6LEP, PCSK1
20phenylephrine44 28 11 2412.5POMC, LEP
21nash449.5LEP, LEPR
22clozapine44 28 49 1112.4LEP, POMC
23olanzapine49 44 28 11 2413.4LEPR, LEP
24h2o2449.4LEP, LEPR
25triacylglycerol449.2LEPR, LEP
26acth449.0LEPR, LEP, POMC
27triiodothyronine449.0LEPR, LEP, POMC
28androstenedione44 2410.0POMC, LEP, LEPR
29corticosterone44 59 2411.0POMC, LEP, LEPR
30cocaine44 1110.0LEPR, LEP, POMC
31thyroxine44 2410.0LEPR, LEP, POMC
32estradiol44 11 2410.9POMC, LEP, LEPR
33ribonucleic acid448.9POMC, PCSK1, LEPR
34testosterone44 59 11 2411.8LEPR, LEP, POMC
35steroid448.6LEPR, LEP, POMC
36dexamethasone44 49 28 1111.5POMC, LEP, LEPR
37gnrh448.4POMC, PCSK1, LEP, LEPR
38progesterone44 59 28 11 2412.4LEPR, LEP, PCSK1, POMC
39arginine448.4POMC, PCSK1, LEP, LEPR
40estrogen448.4POMC, PCSK1, LEP, LEPR
41glucose448.4LEPR, LEP, PCSK1, POMC
42serine448.3LEPR, LEP, PCSK1, POMC
43vegf448.3LEPR, LEP, POMC

GO Terms for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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16Gene Ontology
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Cellular components related to Monogenic Non-Syndromic Obesity, Autosomal Recessive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.0PCSK1, POMC
2extracellular spaceGO:0056158.8LEP, PCSK1, POMC

Biological processes related to Monogenic Non-Syndromic Obesity, Autosomal Recessive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.4LEP, POMC
2peptide hormone processingGO:0164869.4PCSK1, POMC
3energy reserve metabolic processGO:0061129.1LEPR, LEP
4cholesterol metabolic processGO:0082039.0LEP, LEPR
5regulation of insulin secretionGO:0507969.0LEP, PCSK1

Molecular functions related to Monogenic Non-Syndromic Obesity, Autosomal Recessive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4LEP, POMC

Products for genes affiliated with Monogenic Non-Syndromic Obesity, Autosomal Recessive

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Sources for Monogenic Non-Syndromic Obesity, Autosomal Recessive

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3CDC
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14FMA
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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44Novoseek
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50PubMed
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57SNOMED-CT via Orphanet
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