MCID: MNN014
MIFTS: 48

Mononeuritis malady

Immune diseases, Blood diseases, Neuronal diseases categories

Summaries for Mononeuritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Mononeuritis, also known as idiopathic peripheral neuropathy, is related to mononeuritis multiplex and pancreatitis. An important gene associated with Mononeuritis is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds cycloheximide and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and lung, and related mouse phenotype immune system.

Aliases & Classifications for Mononeuritis

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Mononeuritis

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17GeneCards, 18GeneDecks
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Diseases related to Mononeuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1802)
idRelated DiseaseScoreTop Affiliating Genes
1mononeuritis multiplex31.3PRTN3, MPO
2pancreatitis31.1HSPG2, CRP, MPO
3churg-strauss syndrome30.4PRTN3, MPO
4deficiency anemia30.4HSPG2, CRP, PRTN3
5vasculitis30.4CRP, MPO, PRTN3
6polyarteritis nodosa30.3PRTN3, MPO
7hepatitis30.3HSPG2
8arthritis30.2PRTN3, MPO, CRP
9rheumatoid arthritis30.2HSPG2, CRP, MPO, PRTN3
10systemic lupus erythematosus30.1CRP
11arthropathy30.1CRP
12respiratory failure30.1CRP
13adenocarcinoma30.0HSPG2
14purpura30.0HSPG2
15polyneuropathy30.0HSPG2
16alpha 1-antitrypsin deficiency30.0PRTN3
17galactosemia30.0CRP
18glomerulonephritis29.9PRTN3, MPO
19acute pancreatitis29.9MPO, CRP
20hyperthyroidism29.9PRTN3
21atherosclerosis29.9HSPG2, CRP, MPO, PRTN3
22neutropenia29.8MPO, PRTN3
23mediastinitis29.8CRP
24ischemia29.8MPO, HSPG2
25hepatitis c29.7PRTN3, HSPG2
26hypersensitivity vasculitis29.7PRTN3, MPO
27wegener's granulomatosis29.7MPO, PRTN3
28mononeuropathy29.7PRTN3, MPO
29acute leukemia29.7MPO, PRTN3
30asthma29.7PRTN3, MPO
31eosinophilia29.7PRTN3, MPO, HSPG2
32cystic fibrosis29.7PRTN3, MPO, HSPG2
33stroke, ischemic29.5CRP
34proteinuria29.5CRP, MPO, PRTN3
35dermatomyositis29.3HSPG2
36antiphospholipid syndrome29.3HSPG2
37inflammatory bowel disease29.3MPO
38crohn's disease29.3CRP
39connective tissue disease29.3MPO, PRTN3
40primary biliary cirrhosis29.3PRTN3, HSPG2
41ankylosing spondylitis29.3CRP, PRTN3
42ulcerative colitis29.3PRTN3, CRP
43congenital heart defect29.3MPO, CRP
44hereditary angioedema11.0
45angioedema10.9
46hereditary spherocytosis10.9
47hereditary hemorrhagic telangiectasia10.9
48hereditary spastic paraplegia10.9
49colorectal cancer10.9
50breast cancer10.9

Graphical network of the top 20 diseases related to Mononeuritis:



Diseases related to mononeuritis

Clinical Features for Mononeuritis

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Drugs & Therapeutics for Mononeuritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mononeuritis

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Anatomical Context for Mononeuritis

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32MalaCards
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MalaCards organs/tissues related to Mononeuritis:

32
B cells, Skin, Lung, Heart, Small intestine, Colon

Animal Models for Mononeuritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mononeuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0PRTN3, MPO, CRP, HSPG2

Publications for Mononeuritis

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50PubMed
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Articles related to Mononeuritis:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells. (24289971)
2013
2
Livedoid Vasculopathy and Mononeuritis Multiplex, with a Fulminant Hepatic Failure which was caused by Herpes Simplex Hepatitis: A Case Report. (23814745)
2013
3
An unusual cause of mononeuritis multiplex. (23315459)
2013
4
Mononeuritis multiplex in a patient with B-cell prolymphocytic leukaemia: a diagnostic challenge. (24000206)
2013
5
De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha? (22679403)
2012
6
Mononeuritis multiplex complicating systemic lupus erythematosus. (22885442)
2012
7
A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex. (21940653)
2012
8
Kimura disease with necrosis of the limbs and mononeuritis multiplex. (21418278)
2011
9
A case of MPO-ANCA-positive polyarteritis nodosa complicated by exudative otitis media, mononeuritis multiplex, and acute renal failure. (21611757)
2011
10
Extreme hypereosinophilia, Churg-Strauss syndrome and mononeuritis multiplex. (21869702)
2011
11
Abnormal chest X-ray in a patient with mononeuritis multiplex. (20167962)
2010
12
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
13
Cutaneous large B-cell lymphoma of the leg: presenting initially as mononeuritis multiplex. (19495496)
2009
14
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
15
Paraneoplastic mononeuritis multiplex in non-small-cell lung carcinoma. (16564174)
2006
16
Severe proximal myopathy and mononeuritis multiplex in rheumatoid arthritis: manifestations of rheumatoid vasculitis. (16357697)
2005
17
Painful mononeuritis multiplex in idiopathic thrombocytopenic purpura. (15995289)
2005
18
Churg-Strauss syndrome: the use of cyclophosphamide in mononeuritis. (12595649)
2003
19
Successful treatment of refractory mononeuritis multiplex secondary to rheumatoid arthritis with the anti-tumour necrosis factor alpha monoclonal antibody infliximab. (11886980)
2002
20
Localized neurological necrotizing vasculitides. Three cases with isolated mononeuritis multiplex. (11296972)
2001
21
Mononeuritis secondary to rheumatoid arthritis responds to etanercept. (11136899)
2000
22
A case of SjAPgren syndrome associated with multiple mononeuritis and dysautonomia including bilateral tonic pupils]. (9311000)
1997
23
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
24
Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. (8646231)
1996
25
Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. (7897423)
1995
26
Extensive mononeuritis multiplex as a solitary presentation of polyarteritis nodosa. (7852824)
1995
27
Mononeuritis multiplex and vasculitis. Association with anti-neutrophil cytoplasmic autoantibody. (8198467)
1994
28
Mononeuritis multiplex after coelenterate sting. (7830670)
1994
29
Unusual neurologic complications of typhoid fever (aphasia, mononeuritis multiplex, and Guillain-BarrAc syndrome): a report of two cases. (8249195)
1993
30
Nonvasculitic, steroid-responsive mononeuritis multiplex. (8492941)
1993
31
Mononeuritis multiplex in a child with cutaneous polyarteritis. (1348850)
1992
32
BehAset's disease presenting with mononeuritis multiplex [corrected]. (2177579)
1990
33
Vagal mononeuritis caused by herpes simplex virus: association with unilateral vocal cord paralysis. (2346163)
1990
34
Mononeuritis multiplex as an unusual complication of leptospirosis. (2809239)
1989
35
Mononeuritis multiplex: the yield of evaluations for occult rheumatic diseases. (2835572)
1988
36
Periarteritis nodosa with mononeuritis multiplex. (2878916)
1986
37
Plasma exchange in a patient with severe rheumatoid arthritis complicated by mononeuritis multiplex and cutaneous ulcers. (3960239)
1986
38
Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. (2996347)
1985
39
Mononeuritis multiplex and eosinophilia in a patient with asthma. (4014784)
1985
40
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
41
Multiple mononeuropathy or mononeuritis multiplex in diabetics? (7072444)
1982
42
Mononeuritis multiplex due to haemorrhage. (638684)
1978
43
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
44
Mononeuritis multiplex associated with infectious mononucleosis. (4426004)
1974
45
Neuroclinical-pathology conference: Progressive bilateral lower limb weakness and cranial mononeuritis multiplex. (4405881)
1974
46
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
47
Mononeuritis multiplex complicating the post-perfusion syndrome. (5701924)
1968
48
Mononeuritis in association with malignancy. (5977425)
1966
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
50
Repeated pressure mononeuritis; report of case. (13329564)
1956

Genetic Variations for Mononeuritis

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Expression for genes affiliated with Mononeuritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuritis

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Pathways for genes affiliated with Mononeuritis

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37NCBI BioSystems Database
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Pathways related to Mononeuritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PRTN3, MPO
29.3MPO, CRP

Compounds for genes affiliated with Mononeuritis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Mononeuritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.0HSPG2
2cyclophosphamide44 49 1111.9CRP
3cytochalasin b449.8MPO, PRTN3
4aopp449.7MPO, CRP
5sulfasalazine44 28 49 1112.7MPO, CRP
68-isoprostane449.7MPO, CRP
7methacholine44 1110.7MPO, CRP
8infliximab44 49 1111.7PRTN3, CRP
9vitamin b12449.6CRP, MPO
10malondialdehyde449.6MPO, CRP
11rituximab44 49 1111.6PRTN3, CRP
12polyethylene glycol449.6MPO, CRP
13clozapine44 28 49 1112.5MPO, CRP
14azathioprine44 49 2 1112.5PRTN3, CRP
15convulxin449.4CRP, HSPG2
16p002449.4CRP, PRTN3
17propranolol44 28 49 11 2413.4MPO, HSPG2
18prostaglandin f2alpha449.3CRP, HSPG2
19prednisolone44 28 1111.3MPO, CRP
20losartan44 49 28 1112.3CRP, HSPG2
21n-formylmethionyl-leucylphenylalanine449.0PRTN3, MPO, HSPG2
22fmlp449.0HSPG2, MPO, PRTN3
23dmso449.0PRTN3, MPO, HSPG2
24d penicillamine448.9MPO, CRP, HSPG2
25ascorbic acid44 249.9HSPG2, CRP, MPO
26acetylcholine44 49 28 11 2412.9MPO, CRP, HSPG2
27simvastatin44 49 59 28 11 2413.7CRP, HSPG2
28vegf448.7HSPG2, CRP, MPO
29alanine448.6PRTN3, CRP, HSPG2
30retinoic acid44 249.5PRTN3, MPO, HSPG2
31calcium44 49 11 2411.3HSPG2, CRP, MPO, PRTN3

GO Terms for genes affiliated with Mononeuritis

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16Gene Ontology
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Cellular components related to Mononeuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PRTN3, HSPG2
2extracellular spaceGO:0056158.2MPO, CRP, HSPG2

Products for genes affiliated with Mononeuritis

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  • Antibodies
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Sources for Mononeuritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet