MCID: MNN014
MIFTS: 51

Mononeuritis malady

Immune diseases, Blood diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Mononeuritis

About this section


Fully expand this MalaCard
Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards based summary: Mononeuritis, also known as idiopathic peripheral neuropathy, is related to mononeuritis multiplex and churg-strauss syndrome. An important gene associated with Mononeuritis is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds propylthiouracil and cytochalasin b have been mentioned in the context of this disorder. Affiliated tissues include lung, b cells and heart, and related mouse phenotype immune system.

Aliases & Classifications for Mononeuritis

About this section

Related Diseases for Mononeuritis

About this section

Diseases related to Mononeuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1971)
idRelated DiseaseScoreTop Affiliating Genes
1mononeuritis multiplex31.7PRTN3, MPO
2churg-strauss syndrome30.7MPO, PRTN3
3polyarteritis nodosa30.7PRTN3, MPO
4nephritis30.4PRTN3, MPO
5mediastinitis30.3CRP
6vasculitis30.3MPO, PRTN3, CRP
7glomerulonephritis30.2MPO, PRTN3
8hypersensitivity vasculitis30.1MPO, PRTN3
9mononeuropathy30.1MPO, PRTN3
10neutropenia30.1MPO, PRTN3
11arthritis30.1CRP, PRTN3, MPO
12wegener's granulomatosis30.1PRTN3, MPO
13acute pancreatitis29.9MPO, CRP
14acute leukemia29.8PRTN3, MPO
15hepatitis c29.8PRTN3, HSPG2
16cerebrovascular disease29.8CRP, PRTN3
17eosinophilia29.8PRTN3, MPO, HSPG2
18rheumatoid arthritis29.8CRP, PRTN3, MPO, HSPG2
19ankylosing spondylitis29.7CRP, PRTN3
20deficiency anemia29.7CRP, PRTN3, HSPG2
21cystic fibrosis29.7PRTN3, MPO, HSPG2
22primary biliary cirrhosis29.6PRTN3, HSPG2
23systemic lupus erythematosus29.6CRP, PRTN3, MPO, HSPG2
24congenital heart disease29.6CRP, MPO
25pancreatitis29.6CRP, MPO, HSPG2
26pneumonia29.6HSPG2, MPO, CRP
27myeloid leukemia29.5MPO, PRTN3
28ulcerative colitis29.5PRTN3, CRP
29sepsis29.5CRP, PRTN3, MPO
30leukopenia29.4MPO, CRP
31atherosclerosis29.4CRP, PRTN3, MPO, HSPG2
32vascular disease29.4CRP, PRTN3
33proteinuria29.4MPO, PRTN3, CRP
34chronic obstructive pulmonary disease29.1CRP, PRTN3, MPO
35inflammatory bowel disease29.1CRP, PRTN3, MPO
36hereditary angioedema11.0
37angioedema11.0
38hereditary spherocytosis11.0
39hereditary hemorrhagic telangiectasia11.0
40spasticity11.0
41hereditary spastic paraplegia10.9
42paraplegia10.9
43colorectal cancer10.9
44hemochromatosis10.9
45breast cancer10.9
46hereditary neuropathies10.8
47leber hereditary optic neuropathy10.8
48hereditary pancreatitis10.8
49hereditary neuropathy with liability to pressure palsies10.8
50hereditary multiple exostoses10.8

Graphical network of the top 20 diseases related to Mononeuritis:



Diseases related to mononeuritis

Symptoms for Mononeuritis

About this section

Drugs & Therapeutics for Mononeuritis

About this section

Drug clinical trials:

Search ClinicalTrials for Mononeuritis

Search NIH Clinical Center for Mononeuritis

Genetic Tests for Mononeuritis

About this section

Anatomical Context for Mononeuritis

About this section

MalaCards organs/tissues related to Mononeuritis:

32
Lung, B cells, Heart, Small intestine, Colon, Skin, Neutrophil

Animal Models for Mononeuritis or affiliated genes

About this section

MGI Mouse Phenotypes related to Mononeuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0CRP, PRTN3, MPO, HSPG2

Publications for Mononeuritis

About this section

Articles related to Mononeuritis:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Mononeuritis multiplex predicts the need for immunosuppressive or immunomodulatory drugs for EGPA, PAN and MPA patients without poor-prognosis factors. (25153486)
2014
2
Paraneoplastic mononeuritis multiplex as a presenting feature of adenocarcinoma of the lung. (24455360)
2013
3
Livedoid Vasculopathy and Mononeuritis Multiplex, with a Fulminant Hepatic Failure which was caused by Herpes Simplex Hepatitis: A Case Report. (23814745)
2013
4
Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. (24303898)
2013
5
De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha? (22679403)
2012
6
Vasculitic multiplex mononeuritis: polyarteritis nodosa versus cryoglobulinemic vasculitis. (20401485)
2012
7
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
8
Adalimumab induced mononeuritis multiplex in a patient with refractory rheumatoid arthritis: a case report. (18973686)
2008
9
A purpuric rash and mononeuritis multiplex. (18326170)
2008
10
Case of mononeuritis multiplex onset with rituximab therapy for WaldenstrAPm's macroglobulinemia. (17537458)
2007
11
Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. (17401258)
2007
12
Presence of perineuritis in a case of papular purpuric gloves and socks syndrome associated with mononeuritis multiplex attributable to B19 parvovirus. (16635678)
2006
13
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
14
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. (12700924)
2003
15
Paediatric mononeuritis multiplex: a report of three cases and review of the literature. (14561499)
2003
16
Sensory perineuritis presented as a mononeuritis multiplex associated with livedo vasculitis. (11311480)
2001
17
Severe recalcitrant pyoderma gangrenosum responding to a combination of mycophenolate mofetil with cyclosporin and complicated by a mononeuritis. (11251582)
2001
18
Mononeuritis secondary to rheumatoid arthritis responds to etanercept. (11136899)
2000
19
Bell palsy: a herpes simplex mononeuritis? (9677123)
1998
20
A case of SjAPgren syndrome associated with multiple mononeuritis and dysautonomia including bilateral tonic pupils]. (9311000)
1997
21
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
22
Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. (8646231)
1996
23
Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. (7897423)
1995
24
Mononeuritis in two patients with limited cutaneous systemic sclerosis. (8205412)
1994
25
Hypereosinophilic syndrome presenting as recurrent benign mononeuritis multiplex. (8088985)
1994
26
Mononeuritis multiplex in a child with cutaneous polyarteritis. (1348850)
1992
27
Case-of-the-month: perineuritis presenting as mononeuritis multiplex. (1584256)
1992
28
Polyarthritis, mononeuritis multiplex and eczematous ulcerative skin rash in a patient with myelodysplastic syndrome and peripheral large granular lymphocytosis. (1722442)
1991
29
Role of macrophages in onion-bulb formation in localized hypertrophic mononeuritis (LHM). (1860270)
1991
30
BehAset's disease presenting with mononeuritis multiplex [corrected]. (2177579)
1990
31
Hypertrophic mononeuritis clinically presenting with painful legs and moving toes. (2320043)
1990
32
Vagal mononeuritis caused by herpes simplex virus: association with unilateral vocal cord paralysis. (2346163)
1990
33
Mononeuritis multiplex in incomplete BehAset's disease: a case report and the review of the literature. (2680237)
1989
34
Mononeuritis multiplex as an unusual complication of leptospirosis. (2809239)
1989
35
Periarteritis nodosa with mononeuritis multiplex. (2878916)
1986
36
Multiple mononeuritis and radiculitis with erythema, pain, elevated CSF protein and pleocytosis (Bannwarth's syndrome). (6875581)
1983
37
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
38
Mononeuritis cranialis multiplex. (7346515)
1981
39
Lymphoma presenting as mononeuritis multiplex. (7329882)
1981
40
SjAPgren's syndrome and mononeuritis multiplex. (7350862)
1980
41
Isolated vagus nerve palsy and vagal mononeuritis. (7378018)
1980
42
Mononeuritis multiplex due to haemorrhage. (638684)
1978
43
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
44
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
45
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968
46
Mononeuritis in association with malignancy. (5977425)
1966
47
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
48
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963
49
ELECTROMYOGRAPHIC STUDY ON SO-CALLED MONONEURITIS. (14049405)
1963
50
Heredofamilial mononeuritis multiplex with brachial predilection. (13837190)
1960

Variations for Mononeuritis

About this section

Expression for genes affiliated with Mononeuritis

About this section
Expression patterns in normal tissues for genes affiliated with Mononeuritis

Search GEO for disease gene expression data for Mononeuritis.

Pathways for genes affiliated with Mononeuritis

About this section

Pathways related to Mononeuritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PRTN3, MPO
2
Show member pathways
thioredoxin pathway37
9.3CRP, MPO

Compounds for genes affiliated with Mononeuritis

About this section

Compounds related to Mononeuritis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1111.8MPO, PRTN3
2cytochalasin b449.8MPO, PRTN3
3aopp449.8MPO, CRP
4sulfasalazine28 44 50 1112.7MPO, CRP
58-isoprostane449.7CRP, MPO
6methacholine44 50 1111.7CRP, MPO
7infliximab44 50 1111.7CRP, PRTN3
8vitamin b12449.7CRP, MPO
9malondialdehyde449.7CRP, MPO
10rituximab44 50 1111.7PRTN3, CRP
11formaldehyde44 2410.7PRTN3, MPO
12polyethylene glycol449.7MPO, CRP
13clozapine44 28 50 1112.6CRP, MPO
14azathioprine44 2 50 1112.6CRP, PRTN3
15p002449.6CRP, PRTN3
16valine449.6PRTN3, MPO
17prednisolone44 28 1111.6CRP, MPO
18cyclophosphamide44 50 1111.6CRP, MPO
19propranolol44 28 50 24 1113.5MPO, HSPG2
20convulxin449.4CRP, HSPG2
21prostaglandin f2alpha449.4HSPG2, CRP
22chloramphenicol44 2 50 1112.4CRP, MPO
23losartan44 50 28 1112.4HSPG2, CRP
24simvastatin44 50 61 28 24 1114.3HSPG2, CRP
25phosphatidylserine44 28 1111.3PRTN3, HSPG2
26prostacyclin449.2HSPG2, CRP
27n acetylcysteine449.2MPO, CRP
28aspirin44 50 28 2412.1HSPG2, CRP
29histamine44 28 2411.1MPO, HSPG2
30n-formylmethionyl-leucylphenylalanine449.0PRTN3, MPO, HSPG2
31fmlp449.0PRTN3, MPO, HSPG2
32dmso449.0HSPG2, MPO, PRTN3
33d penicillamine448.9CRP, MPO, HSPG2
34ascorbic acid44 249.9CRP, MPO, HSPG2
35acetylcholine44 50 28 24 1112.9CRP, MPO, HSPG2
36cycloheximide448.9HSPG2, PRTN3, CRP
37retinoic acid44 249.9HSPG2, MPO, PRTN3
38vegf448.9CRP, MPO, HSPG2
39alanine448.8CRP, PRTN3, HSPG2
40indomethacin44 28 61 1111.8MPO, HSPG2
41serine448.6PRTN3, MPO, HSPG2
42calcium44 50 24 1111.4CRP, PRTN3, MPO, HSPG2

GO Terms for genes affiliated with Mononeuritis

About this section

Cellular components related to Mononeuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.8PRTN3, HSPG2
2extracellular vesicular exosomeGO:0700628.6PRTN3, MPO, HSPG2
3extracellular spaceGO:0056158.4CRP, MPO, HSPG2

Biological processes related to Mononeuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.3CRP, MPO

Molecular functions related to Mononeuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:0468728.5CRP, MPO, HSPG2

Products for genes affiliated with Mononeuritis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Mononeuritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet