Mononeuritis malady

Wikipedia: Peripheral neuropathy is damage to nerves of the peripheral nervous system, which may be caused either...⁴⁴ more...

MalaCards: Mononeuritis, also known as idiopathic peripheral neuropathy, is related to neuropathy and mononeuritis multiplex. An important gene associated with Mononeuritis is PRTN3 (proteinase 3). The compounds propylthiouracil and cytochalasin b have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Aliases & Descriptions:

mononeuritis 6 43 idiopathic peripheral neuropathy 6 43

mononeuritis of unspecified site nos 6 hereditary 6

Diseases related to mononeuritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1036)

id	Related Disease	Score	Top Affiliating Genes
1	neuropathy	34.1	HSPG2, CRP, MPO
2	mononeuritis multiplex	30.5	PRTN3, CRP, MPO
3	pancreatitis	30.2	PRTN3, CRP, MPO, HSPG2
4	thrombosis	30.0	MPO, HSPG2, CRP
5	anemia	29.3	PRTN3, HSPG2, CRP, MPO
6	gastric cancer	29.2	MPO, HSPG2, PRTN3, CRP
7	thyroiditis	28.7	MPO, PRTN3, CRP, HSPG2
8	gingivitis	28.0	CRP, HSPG2, MPO, PRTN3
9	peripheral neuropathy	27.2	HSPG2, MPO, CRP
10	factor v leiden thrombophilia	26.9	HSPG2, CRP
11	alpha 1-antitrypsin deficiency	26.5	PRTN3, CRP, MPO
12	hyperthyroidism	26.5	CRP, PRTN3, MPO
13	wegener's granulomatosis	26.5	PRTN3, CRP, MPO
14	sinusitis	26.5	PRTN3, MPO, CRP
15	arthropathy	26.3	HSPG2, CRP
16	fabry disease	26.2	MPO, CRP
17	pulmonary embolism	26.1	MPO, CRP
18	diabetes insipidus	26.1	MPO, CRP
19	nephritis	26.0	PRTN3, MPO, CRP
20	purpura	25.7	MPO, HSPG2, CRP, PRTN3
21	nephropathy	25.7	PRTN3, MPO, HSPG2, CRP
22	vasculitis	25.7	PRTN3, CRP, HSPG2, MPO
23	fibrosis	25.7	PRTN3, HSPG2, MPO, CRP
24	neutropenia	24.7	MPO, PRTN3, CRP
25	atherosclerosis	24.7	CRP, HSPG2, MPO, PRTN3
26	nephrotic syndrome	24.7	CRP, MPO, HSPG2
27	glomerulonephritis	24.6	PRTN3, MPO, CRP
28	mononeuropathy	24.6	MPO, PRTN3
29	neuritis	24.3	HSPG2, MPO
30	behcet's disease	24.2	HSPG2, CRP
31	antiphospholipid syndrome	23.9	CRP, HSPG2
32	systemic lupus erythematosus	23.9	HSPG2, MPO, CRP, PRTN3
33	lupus erythematosus	23.9	HSPG2, MPO, CRP, PRTN3
34	arthritis	23.8	MPO, PRTN3, CRP, HSPG2
35	dermatomyositis	23.4	HSPG2, CRP, MPO
36	proteinuria	23.3	PRTN3, MPO, CRP
37	chronic obstructive pulmonary disease	23.3	CRP, PRTN3, MPO
38	laryngitis	23.2	MPO, HSPG2, CRP
39	crohn's disease	23.1	CRP, MPO, PRTN3
40	pulmonary disease	22.9	PRTN3, CRP, MPO
41	vascular disease	22.6	PRTN3, CRP, MPO, HSPG2
42	cystic fibrosis	22.6	HSPG2, CRP, MPO, PRTN3
43	galactosemia	22.6	HSPG2, MPO, PRTN3, CRP
44	hepatitis c	22.5	MPO, CRP, PRTN3, HSPG2
45	rheumatoid arthritis	22.5	PRTN3, CRP, MPO, HSPG2
46	rapidly progressive glomerulonephritis	12.9	MPO, PRTN3
47	hypersensitivity vasculitis	12.9	PRTN3, MPO
48	primary biliary cirrhosis	12.8	HSPG2, PRTN3
49	bronchitis	12.8	MPO, PRTN3
50	toxic epidermal necrolysis	12.8	HSPG2, MPO

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to mononeuritis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.0	MPO, HSPG2, CRP, PRTN3

Articles related to mononeuritis:

id	Title	Authors	Year	Affiliating Genes
1	Orbital inflammatory pseudotumor due to hypersensitiv ity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-pos itive Wegener's granulomatosis. (12700924)	Kaufmann J.... Stein G.	2003	CRP
2	A case of SjAPgren syndrome associated with multiple mononeuritis and dysautonomia including bilateral tonic pupils (9311000)	Tajima Y.... Tashiro K.	1997	HSPG2

Genes related to mononeuritis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PRTN3	proteinase 3	11.0
2	MPO	myeloperoxidase	11.0
3	CRP	C-reactive protein, pentraxin-related	11.0	Publications
4	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications

Compounds related to mononeuritis according to GeneDecks:

(show all 28)

id	Compound	Score	Top Affiliating Genes
1	propylthiouracil32 9 9	11.7	PRTN3, MPO
2	cytochalasin b32	9.6	MPO, PRTN3
3	propranolol32 34 9 18 9	13.5	MPO, HSPG2
4	convulxin32	9.5	HSPG2, CRP
5	infliximab32 9 9	11.4	CRP, PRTN3
6	aopp32	9.4	MPO, CRP
7	prostaglandin f2alpha32	9.4	HSPG2, CRP
8	sulfasalazine32 9 9	11.4	CRP, MPO
9	rituximab32 34 9 9	12.4	CRP, PRTN3
10	8-isoprostane32	9.4	MPO, CRP
11	methacholine32 9 9	11.3	CRP, MPO
12	losartan32 34 9 9	12.3	HSPG2, CRP
13	vitamin b1232	9.3	MPO, CRP
14	malondialdehyde32	9.3	CRP, MPO
15	n-formylmethionyl-leucylphenylalanine32	9.2	MPO, HSPG2, PRTN3
16	clozapine32 34 9 9	12.2	CRP, MPO
17	fmlp32	9.2	PRTN3, HSPG2, MPO
18	dmso32	9.2	MPO, HSPG2, PRTN3
19	azathioprine32 34 9 9	12.1	PRTN3, CRP
20	polyethylene glycol32	9.1	MPO, CRP
21	d penicillamine32	8.9	MPO, HSPG2, CRP
22	cycloheximide32	8.9	HSPG2, CRP, PRTN3
23	ascorbic acid32 18	9.9	MPO, HSPG2, CRP
24	acetylcholine32 9 18 9	11.8	MPO, HSPG2, CRP
25	p00232	8.8	CRP, PRTN3
26	alanine32	8.6	HSPG2, CRP, PRTN3
27	vegf32	8.4	MPO, HSPG2, CRP
28	calcium32 9 18 9	11.1	MPO, HSPG2, CRP, PRTN3

Cellular components related to mononeuritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.5	MPO, HSPG2, CRP