MCID: MNN014
MIFTS: 40

Mononeuritis malady

Immune, Blood, Neuronal categories

Summaries for Mononeuritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Mononeuritis, also known as idiopathic peripheral neuropathy, is related to mononeuritis multiplex and churg-strauss syndrome. An important gene associated with Mononeuritis is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds cycloheximide and cyclophosphamide have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Aliases & Classifications for Mononeuritis

Sources:
8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Mononeuritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mononeuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1598)
idRelated DiseaseScoreTop Affiliating Genes
1mononeuritis multiplex31.3PRTN3, MPO
2churg-strauss syndrome30.4PRTN3, MPO
3vasculitis30.4CRP, MPO, PRTN3
4polyarteritis nodosa30.4PRTN3, MPO
5deficiency anemia30.4HSPG2, CRP, PRTN3
6arthritis30.3PRTN3, MPO, CRP
7systemic lupus erythematosus30.2CRP
8hepatitis c30.2PRTN3, HSPG2
9nephritis30.1MPO, PRTN3
10arthropathy30.1CRP
11adenocarcinoma30.0HSPG2
12acute pancreatitis30.0MPO, CRP
13atherosclerosis29.9HSPG2, CRP, MPO, PRTN3
14rheumatic disease29.8CRP
15acute leukemia29.8MPO, PRTN3
16asthma29.8PRTN3, MPO
17alpha 1-antitrypsin deficiency29.7PRTN3
18cystic fibrosis29.7PRTN3, MPO, HSPG2
19sepsis29.7PRTN3, MPO, CRP
20crohn's disease29.6CRP
21stroke, ischemic29.6CRP
22antiphospholipid syndrome29.4HSPG2
23pulmonary disease, chronic obstructive29.4CRP
24primary biliary cirrhosis29.4PRTN3, HSPG2
25ankylosing spondylitis29.4CRP, PRTN3
26ulcerative colitis29.4PRTN3, CRP
27leukopenia29.4MPO, CRP
28hereditary angioedema11.0
29angioedema11.0
30hereditary spherocytosis11.0
31hereditary hemorrhagic telangiectasia11.0
32hereditary spastic paraplegia10.9
33colorectal cancer10.9
34hemochromatosis10.9
35leber hereditary optic neuropathy10.9
36hereditary pancreatitis10.8
37hereditary elliptocytosis10.8
38hereditary multiple exostoses10.8
39hereditary amyloidosis10.8
40amyloidosis10.7
41hereditary ataxia10.7
42ataxia10.7
43tyrosinemia10.7
44hereditary breast ovarian cancer10.6
45hereditary coproporphyria10.6
46hereditary diffuse gastric cancer10.6
47diffuse gastric cancer10.6
48hereditary neuropathies10.5
49arteriovenous malformation10.5
50rickets10.5

Graphical network of the top 20 diseases related to Mononeuritis:



Diseases related to mononeuritis

Clinical Features for Mononeuritis

Drugs & Therapeutics for Mononeuritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mononeuritis

Drug clinical trials:

Search ClinicalTrials for Mononeuritis

Search NIH Clinical Center for Mononeuritis

Search CenterWatch for Mononeuritis

Genetic Tests for Mononeuritis

Anatomical Context for Mononeuritis

Animal Models for Mononeuritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Mononeuritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0PRTN3, MPO, CRP, HSPG2

Publications for Mononeuritis

Sources:
51PubMed
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Articles related to Mononeuritis:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Neurosarcoidosis Presenting as Mononeuritis Multiplex. (24196972)
2013
2
Mononeuritis multiplex in a patient with B-cell prolymphocytic leukaemia: a diagnostic challenge. (24000206)
2013
3
De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha? (22679403)
2012
4
Mononeuritis multiplex complicating systemic lupus erythematosus. (22885442)
2012
5
A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex. (21940653)
2012
6
Meningococcemia presenting as acute painful mononeuritis multiplex. (22100105)
2012
7
Extreme hypereosinophilia, Churg-Strauss syndrome and mononeuritis multiplex. (21869702)
2011
8
Abnormal chest X-ray in a patient with mononeuritis multiplex. (20167962)
2010
9
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
10
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
11
Case of mononeuritis multiplex onset with rituximab therapy for WaldenstrAPm's macroglobulinemia. (17537458)
2007
12
Severe proximal myopathy and mononeuritis multiplex in rheumatoid arthritis: manifestations of rheumatoid vasculitis. (16357697)
2005
13
Mononeuritis multiplex secondary to sarcoidosis. (15708231)
2005
14
ANCA-associated giant cell arteritis presenting with mononeuritis multiplex and central retinal artery occlusion: a case report. (15024142)
2004
15
Vasculitic mononeuritis multiplex induced by valacyclovir. (15159513)
2004
16
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. (12700924)
2003
17
Mononeuritis multiplex, protein-losing gastroenteropathy, and choroidopathy seen together in a case of systemic lupus erythematosus. (24387216)
2003
18
Successful treatment of refractory mononeuritis multiplex secondary to rheumatoid arthritis with the anti-tumour necrosis factor alpha monoclonal antibody infliximab. (11886980)
2002
19
Localized neurological necrotizing vasculitides. Three cases with isolated mononeuritis multiplex. (11296972)
2001
20
Joint and muscle pain with mononeuritis multiplex, tetraparesis, and myocardial infarction in a previously healthy adult. (11602463)
2001
21
Mononeuritis secondary to rheumatoid arthritis responds to etanercept. (11136899)
2000
22
Bell palsy: a herpes simplex mononeuritis? (9677123)
1998
23
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
24
Extensive mononeuritis multiplex as a solitary presentation of polyarteritis nodosa. (7852824)
1995
25
Mononeuritis multiplex. A harbinger of acute leukemia in relapse. (8198473)
1994
26
Mononeuritis multiplex after coelenterate sting. (7830670)
1994
27
Unusual neurologic complications of typhoid fever (aphasia, mononeuritis multiplex, and Guillain-BarrAc syndrome): a report of two cases. (8249195)
1993
28
Polyarthritis, mononeuritis multiplex and eczematous ulcerative skin rash in a patient with myelodysplastic syndrome and peripheral large granular lymphocytosis. (1722442)
1991
29
Role of macrophages in onion-bulb formation in localized hypertrophic mononeuritis (LHM). (1860270)
1991
30
BehAset's disease presenting with mononeuritis multiplex [corrected]. (2177579)
1990
31
Hypertrophic mononeuritis clinically presenting with painful legs and moving toes. (2320043)
1990
32
Mononeuritis multiplex in Plasmodium falciparum malaria. (2260166)
1990
33
Mononeuritis multiplex as an unusual complication of leptospirosis. (2809239)
1989
34
Mononeuritis multiplex and occipital infarction complicating giant cell arteritis. (2543474)
1989
35
Solitary plasmacytoma of the skull revealed by a mononeuritis multiplex associated with immune complex vasculitis. (2530991)
1989
36
Mononeuritis multiplex: the yield of evaluations for occult rheumatic diseases. (2835572)
1988
37
Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. (3728548)
1986
38
Plasma exchange in a patient with severe rheumatoid arthritis complicated by mononeuritis multiplex and cutaneous ulcers. (3960239)
1986
39
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
40
Lymphoma presenting as mononeuritis multiplex. (7329882)
1981
41
SjAPgren's syndrome and mononeuritis multiplex. (7350862)
1980
42
Mononeuritis multiplex due to haemorrhage. (638684)
1978
43
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
44
Mononeuritis multiplex in a patient with macroglobulinaemia. (825616)
1976
45
Mononeuritis multiplex occurring in a diabetic patient with Hb C disease. (4704497)
1973
46
Mononeuritis multiplex complicating the post-perfusion syndrome. (5701924)
1968
47
Mononeuritis in association with malignancy. (5977425)
1966
48
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
49
MONONEURITIS MULTIPLEX. (14250833)
1964
50
ELECTROMYOGRAPHIC STUDY ON SO-CALLED MONONEURITIS. (14049405)
1963

Genetic Variations for Mononeuritis

Expression for genes affiliated with Mononeuritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuritis

Search GEO for disease gene expression data for Mononeuritis.

Pathways for genes affiliated with Mononeuritis

Sources:
38NCBI BioSystems Database
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Pathways related to Mononeuritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PRTN3, MPO
29.3MPO, CRP

Compounds for genes affiliated with Mononeuritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 24HMDB, 60Tocris Bioscience
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Compounds related to Mononeuritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.0HSPG2
2cyclophosphamide45 50 1111.9CRP
3cytochalasin b459.8MPO, PRTN3
4aopp459.7MPO, CRP
5sulfasalazine45 29 50 1112.7MPO, CRP
68-isoprostane459.7MPO, CRP
7methacholine45 1110.7MPO, CRP
8infliximab45 50 1111.7PRTN3, CRP
9vitamin b12459.6CRP, MPO
10malondialdehyde459.6MPO, CRP
11rituximab45 50 1111.6PRTN3, CRP
12polyethylene glycol459.6MPO, CRP
13clozapine45 29 50 1112.5MPO, CRP
14azathioprine45 50 2 1112.5PRTN3, CRP
15convulxin459.4CRP, HSPG2
16p002459.4CRP, PRTN3
17propranolol45 29 50 11 2413.4MPO, HSPG2
18prostaglandin f2alpha459.3CRP, HSPG2
19prednisolone45 29 1111.3MPO, CRP
20losartan45 50 29 1112.3CRP, HSPG2
21n-formylmethionyl-leucylphenylalanine459.0PRTN3, MPO, HSPG2
22fmlp459.0HSPG2, MPO, PRTN3
23dmso459.0PRTN3, MPO, HSPG2
24d penicillamine458.9MPO, CRP, HSPG2
25ascorbic acid45 249.9HSPG2, CRP, MPO
26acetylcholine45 50 29 11 2412.9MPO, CRP, HSPG2
27simvastatin45 50 60 29 11 2413.7CRP, HSPG2
28vegf458.7HSPG2, CRP, MPO
29alanine458.6PRTN3, CRP, HSPG2
30retinoic acid45 249.5PRTN3, MPO, HSPG2
31calcium45 50 11 2411.3HSPG2, CRP, MPO, PRTN3

GO Terms for genes affiliated with Mononeuritis

Sources:
16Gene Ontology
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Cellular components related to Mononeuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1PRTN3, HSPG2
2extracellular spaceGO:0056158.2MPO, CRP, HSPG2

Products for genes affiliated with Mononeuritis

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Sources for Mononeuritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet