MCID: MNN002
MIFTS: 31

Mononeuritis Multiplex malady

Summaries for Mononeuritis Multiplex

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64Wikipedia, 33MalaCards
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Wikipedia:64 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Mononeuritis Multiplex is related to vasculitis and polyarteritis nodosa. An important gene associated with Mononeuritis Multiplex is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds cytochalasin b and n-formylmethionyl-leucylphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and heart.

Aliases & Classifications for Mononeuritis Multiplex

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 27ICD9CM, 57SNOMED-CT
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Aliases & Descriptions:

mononeuritis multiplex 8 43 45 61


External Ids:

Disease Ontology8 DOID:1835
NCIt40 C70938
SNOMED-CT57 30292005
MeSH35 D020422
ICD9CM27 354.5

Related Diseases for Mononeuritis Multiplex

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mononeuritis Multiplex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.7MPO, PRTN3, CRP
2polyarteritis nodosa30.7MPO, PRTN3
3churg-strauss syndrome30.7MPO, PRTN3
4arthritis30.6CRP, MPO, PRTN3
5systemic lupus erythematosus30.5CRP
6hepatitis c30.5PRTN3
7rheumatic disease30.2CRP
8acute leukemia30.1MPO, PRTN3
9asthma30.1PRTN3, MPO
10n syndrome10.5
11macroglobulinemia10.4
12leptospirosis10.4
13cryoglobulinemia10.3
14lepromatous leprosy10.3
15hepatitis a10.3
16chronic inflammatory demyelinating polyneuropathy10.3
17central retinal artery occlusion10.1
18kimura disease10.1
19neurofibromatosis10.1
20acalculous cholecystitis10.1
21granulomatous angiitis10.1
22diabetic polyneuropathy10.1
23hepatitis e10.1
24aseptic meningitis10.1
25small cell carcinoma10.1
26lyme disease10.1
27infectious mononucleosis10.1
28orbital granuloma10.1
29typhoid fever10.1
30scrub typhus10.1
31plasmodium falciparum malaria10.1
32horner's syndrome10.1
33aphasia10.1
34brachial plexus neuropathy10.1
35typhus10.1
36viral hepatitis10.1
37hereditary neuralgic amyotrophy10.1
38allergic angiitis10.1
39hypereosinophilic syndrome10.1
40meningococcemia10.1
41periarteritis nodosa10.1
42rheumatoid vasculitis10.1
43guillain-barr� syndrome10.1
44neurosarcoidosis10.1
45pulmonary disease, chronic obstructive10.0CRP
46pelvic inflammatory disease10.0CRP
47carotid stenosis10.0CRP
48appendicitis10.0CRP
49alpha 1-antitrypsin deficiency10.0PRTN3
50chorioamnionitis10.0CRP

Graphical network of the top 20 diseases related to Mononeuritis Multiplex:



Diseases related to mononeuritis multiplex

Clinical Features for Mononeuritis Multiplex

Drugs & Therapeutics for Mononeuritis Multiplex

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mononeuritis Multiplex

Anatomical Context for Mononeuritis Multiplex

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33MalaCards
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MalaCards organs/tissues related to Mononeuritis Multiplex:

33
Skin, Lung, Heart, Small intestine, Colon, B cells

Animal Models for Mononeuritis Multiplex or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mononeuritis Multiplex

Sources:
51PubMed
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Articles related to Mononeuritis Multiplex:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells. (24289971)
2013
2
Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. (24303898)
2013
3
Neurosarcoidosis Presenting as Mononeuritis Multiplex. (24196972)
2013
4
Mononeuritis multiplex in a patient with B-cell prolymphocytic leukaemia: a diagnostic challenge. (24000206)
2013
5
Mononeuritis multiplex complicating systemic lupus erythematosus. (22885442)
2012
6
Mononeuritis multiplex following leptospirosis. (23287358)
2012
7
Meningococcemia presenting as acute painful mononeuritis multiplex. (22100105)
2012
8
Extreme hypereosinophilia, Churg-Strauss syndrome and mononeuritis multiplex. (21869702)
2011
9
Abnormal chest X-ray in a patient with mononeuritis multiplex. (20167962)
2010
10
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
11
A purpuric rash and mononeuritis multiplex. (18326170)
2008
12
Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. (17401258)
2007
13
Presence of perineuritis in a case of papular purpuric gloves and socks syndrome associated with mononeuritis multiplex attributable to B19 parvovirus. (16635678)
2006
14
Paraneoplastic mononeuritis multiplex in non-small-cell lung carcinoma. (16564174)
2006
15
Severe proximal myopathy and mononeuritis multiplex in rheumatoid arthritis: manifestations of rheumatoid vasculitis. (16357697)
2005
16
Painful mononeuritis multiplex in idiopathic thrombocytopenic purpura. (15995289)
2005
17
Mononeuritis multiplex secondary to sarcoidosis. (15708231)
2005
18
ANCA-associated giant cell arteritis presenting with mononeuritis multiplex and central retinal artery occlusion: a case report. (15024142)
2004
19
Vasculitic mononeuritis multiplex induced by valacyclovir. (15159513)
2004
20
Mononeuritis multiplex, protein-losing gastroenteropathy, and choroidopathy seen together in a case of systemic lupus erythematosus. (24387216)
2003
21
Successful treatment of refractory mononeuritis multiplex secondary to rheumatoid arthritis with the anti-tumour necrosis factor alpha monoclonal antibody infliximab. (11886980)
2002
22
Sensory perineuritis presented as a mononeuritis multiplex associated with livedo vasculitis. (11311480)
2001
23
Localized neurological necrotizing vasculitides. Three cases with isolated mononeuritis multiplex. (11296972)
2001
24
Neurolymphomatosis presenting as mononeuritis multiplex. (18639200)
1999
25
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
26
Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. (8646231)
1996
27
Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. (7897423)
1995
28
Extensive mononeuritis multiplex as a solitary presentation of polyarteritis nodosa. (7852824)
1995
29
Hypereosinophilic syndrome presenting as recurrent benign mononeuritis multiplex. (8088985)
1994
30
Mononeuritis multiplex. A harbinger of acute leukemia in relapse. (8198473)
1994
31
Mononeuritis multiplex after coelenterate sting. (7830670)
1994
32
Unusual neurologic complications of typhoid fever (aphasia, mononeuritis multiplex, and Guillain-BarrAc syndrome): a report of two cases. (8249195)
1993
33
Nonvasculitic, steroid-responsive mononeuritis multiplex. (8492941)
1993
34
Mononeuritis multiplex in Plasmodium falciparum malaria. (2260166)
1990
35
Mononeuritis multiplex and occipital infarction complicating giant cell arteritis. (2543474)
1989
36
Solitary plasmacytoma of the skull revealed by a mononeuritis multiplex associated with immune complex vasculitis. (2530991)
1989
37
Mononeuritis multiplex: the yield of evaluations for occult rheumatic diseases. (2835572)
1988
38
Periarteritis nodosa with mononeuritis multiplex. (2878916)
1986
39
Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. (3728548)
1986
40
Plasma exchange in a patient with severe rheumatoid arthritis complicated by mononeuritis multiplex and cutaneous ulcers. (3960239)
1986
41
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
42
Multiple mononeuropathy or mononeuritis multiplex in diabetics? (7072444)
1982
43
Mononeuritis multiplex due to haemorrhage. (638684)
1978
44
Mononeuritis multiplex in a patient with macroglobulinaemia. (825616)
1976
45
Mononeuritis multiplex occurring in a diabetic patient with Hb C disease. (4704497)
1973
46
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
47
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968
48
Mononeuritis multiplex complicating the post-perfusion syndrome. (5701924)
1968
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
50
Heredofamilial mononeuritis multiplex with brachial predilection. (13837190)
1960

Genetic Variations for Mononeuritis Multiplex

Expression for genes affiliated with Mononeuritis Multiplex

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuritis Multiplex

Search GEO for disease gene expression data for Mononeuritis Multiplex.

Pathways for genes affiliated with Mononeuritis Multiplex

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38NCBI BioSystems Database
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Pathways related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PRTN3, MPO
29.0MPO, CRP

Compounds for genes affiliated with Mononeuritis Multiplex

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1cytochalasin b459.6PRTN3, MPO
2n-formylmethionyl-leucylphenylalanine459.6PRTN3, MPO
3infliximab45 50 1111.4CRP, PRTN3
4aopp459.4MPO, CRP
5rituximab45 50 1111.4CRP, PRTN3
6d penicillamine459.4MPO, CRP
7sulfasalazine45 29 50 1112.4MPO, CRP
88-isoprostane459.4CRP, MPO
9formaldehyde45 2410.3PRTN3, MPO
10methacholine45 1110.3CRP, MPO
11azathioprine45 50 2 1112.3CRP, PRTN3
12vitamin b12459.3MPO, CRP
13malondialdehyde459.3MPO, CRP
14p002459.3PRTN3, CRP
15polyethylene glycol459.3MPO, CRP
16clozapine45 29 50 1112.2MPO, CRP
17fmlp459.2MPO, PRTN3
18prednisolone45 29 1111.1CRP, MPO
19cyclophosphamide45 50 1111.1MPO, CRP
20chloramphenicol45 2 1111.0MPO, CRP
21dmso459.0PRTN3, MPO

GO Terms for genes affiliated with Mononeuritis Multiplex

Products for genes affiliated with Mononeuritis Multiplex

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Sources for Mononeuritis Multiplex

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet