MCID: MNN002
MIFTS: 38

Mononeuritis Multiplex malady

Rare diseases, Neuronal diseases categories

Summaries for Mononeuritis Multiplex

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66Wikipedia, 34MalaCards
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Wikipedia:66 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards: Mononeuritis Multiplex is related to polyarteritis nodosa and churg-strauss syndrome. An important gene associated with Mononeuritis Multiplex is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds propylthiouracil and cytochalasin b have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and lung, and related mouse phenotype immune system.

Aliases & Classifications for Mononeuritis Multiplex

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9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

mononeuritis multiplex 9 44 46 63


External Ids:

Disease Ontology9 DOID:1835
MeSH36 D020422
SNOMED-CT59 30292005
ICD9CM28 354.5
NCIt41 C70938

Related Diseases for Mononeuritis Multiplex

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18GeneCards, 19GeneDecks
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Diseases related to Mononeuritis Multiplex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1polyarteritis nodosa30.7PRTN3, MPO
2churg-strauss syndrome30.7MPO, PRTN3
3vasculitis30.7CRP, PRTN3, MPO
4arthritis30.6CRP, PRTN3, MPO
5rheumatoid arthritis30.6MPO, PRTN3, CRP
6systemic lupus erythematosus30.5CRP, PRTN3, MPO
7hypersensitivity vasculitis30.2PRTN3, MPO
8mononeuropathy30.2MPO, PRTN3
9wegener's granulomatosis30.2PRTN3, MPO
10pneumonia30.2CRP, MPO
11eosinophilia30.2MPO, PRTN3
12acute leukemia30.2PRTN3, MPO
13asthma30.1PRTN3, MPO
14mononeuritis11.1
15hepatitis10.4
16leptospirosis10.4
17macroglobulinemia10.4
18leprosy10.4
19lupus erythematosus10.4
20cryoglobulinemia10.3
21lepromatous leprosy10.3
22hepatitis a10.3
23demyelinating polyneuropathy10.3
24mononeuritis of upper limb and mononeuritis multiplex10.3
25neuropathy10.3
26polyneuropathy10.3
27purpura10.3
28hereditary neuralgic amyotrophy10.3
29chronic inflammatory demyelinating polyneuropathy10.3
30kimura disease10.1
31neurofibromatosis10.1
32hepatitis c10.1
33granulomatous angiitis10.1
34acalculous cholecystitis10.1
35lyme disease10.1
36hepatitis b10.1
37infectious mononucleosis10.1
38horner's syndrome10.1
39q fever10.1
40aseptic meningitis10.1
41plasmodium falciparum malaria10.1
42scrub typhus10.1
43typhoid fever10.1
44central retinal artery occlusion10.1
45aphasia10.1
46brachial plexus neuropathy10.1
47cholecystitis10.1
48diabetes mellitus10.1
49herpes simplex10.1
50leukemia10.1

Graphical network of the top 20 diseases related to Mononeuritis Multiplex:



Diseases related to mononeuritis multiplex

Symptoms for Mononeuritis Multiplex

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Drugs & Therapeutics for Mononeuritis Multiplex

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mononeuritis Multiplex

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Anatomical Context for Mononeuritis Multiplex

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34MalaCards
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MalaCards organs/tissues related to Mononeuritis Multiplex:

34
B cells, Skin, Lung, Heart, Colon, Small intestine

Animal Models for Mononeuritis Multiplex or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Mononeuritis Multiplex:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5CRP, PRTN3, MPO

Publications for Mononeuritis Multiplex

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53PubMed
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Articles related to Mononeuritis Multiplex:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells. (24289971)
2013
2
Livedoid Vasculopathy and Mononeuritis Multiplex, with a Fulminant Hepatic Failure which was caused by Herpes Simplex Hepatitis: A Case Report. (23814745)
2013
3
Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. (24303898)
2013
4
An unusual cause of mononeuritis multiplex. (23315459)
2013
5
De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha? (22679403)
2012
6
Mononeuritis multiplex complicating systemic lupus erythematosus. (22885442)
2012
7
A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex. (21940653)
2012
8
Cutaneous large B-cell lymphoma of the leg: presenting initially as mononeuritis multiplex. (19495496)
2009
9
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
10
Adalimumab induced mononeuritis multiplex in a patient with refractory rheumatoid arthritis: a case report. (18973686)
2008
11
A purpuric rash and mononeuritis multiplex. (18326170)
2008
12
Case of mononeuritis multiplex onset with rituximab therapy for WaldenstrAPm's macroglobulinemia. (17537458)
2007
13
Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. (17401258)
2007
14
Presence of perineuritis in a case of papular purpuric gloves and socks syndrome associated with mononeuritis multiplex attributable to B19 parvovirus. (16635678)
2006
15
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
16
ANCA-associated giant cell arteritis presenting with mononeuritis multiplex and central retinal artery occlusion: a case report. (15024142)
2004
17
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. (12700924)
2003
18
Paediatric mononeuritis multiplex: a report of three cases and review of the literature. (14561499)
2003
19
Sensory perineuritis presented as a mononeuritis multiplex associated with livedo vasculitis. (11311480)
2001
20
Th2 shift in mononeuritis multiplex and increase of Th2 cells in chronic inflammatory demyelinating polyneuropathy: an intracellular cytokine analysis. (11718750)
2001
21
Neurolymphomatosis presenting as mononeuritis multiplex. (18639200)
1999
22
Horner's syndrome associated with mononeuritis multiplex due to cytomegalovirus as the initial manifestation in a patient with AIDS. (9543329)
1998
23
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
24
Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. (8646231)
1996
25
Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. (7897423)
1995
26
Hypereosinophilic syndrome presenting as recurrent benign mononeuritis multiplex. (8088985)
1994
27
Mononeuritis multiplex. A harbinger of acute leukemia in relapse. (8198473)
1994
28
Mononeuritis multiplex and vasculitis. Association with anti-neutrophil cytoplasmic autoantibody. (8198467)
1994
29
Churg-Strauss syndrome (allergic granulomatous angiitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. (8012511)
1994
30
Mononeuritis multiplex in a child with cutaneous polyarteritis. (1348850)
1992
31
Case-of-the-month: perineuritis presenting as mononeuritis multiplex. (1584256)
1992
32
Mononeuritis multiplex associated with cryoglobulinemia in HIV infection. (1436518)
1992
33
Polyarthritis, mononeuritis multiplex and eczematous ulcerative skin rash in a patient with myelodysplastic syndrome and peripheral large granular lymphocytosis. (1722442)
1991
34
BehAset's disease presenting with mononeuritis multiplex [corrected]. (2177579)
1990
35
Mononeuritis multiplex in incomplete BehAset's disease: a case report and the review of the literature. (2680237)
1989
36
Mononeuritis multiplex as an unusual complication of leptospirosis. (2809239)
1989
37
Periarteritis nodosa with mononeuritis multiplex. (2878916)
1986
38
Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. (3728548)
1986
39
Mononeuritis multiplex following jellyfish stings. (6142678)
1984
40
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
41
Lymphoma presenting as mononeuritis multiplex. (7329882)
1981
42
SjAPgren's syndrome and mononeuritis multiplex. (7350862)
1980
43
Mononeuritis multiplex due to haemorrhage. (638684)
1978
44
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
45
Mononeuritis multiplex occurring in a diabetic patient with Hb C disease. (4704497)
1973
46
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
47
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968
48
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963
50
Heredofamilial mononeuritis multiplex with brachial predilection. (13837190)
1960

Variations for Mononeuritis Multiplex

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Expression for genes affiliated with Mononeuritis Multiplex

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuritis Multiplex

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Pathways for genes affiliated with Mononeuritis Multiplex

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51PathCards, 39NCBI BioSystems Database
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Pathways related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PRTN3, MPO
2
Show member pathways
thioredoxin pathway39
9.0CRP, MPO

Compounds for genes affiliated with Mononeuritis Multiplex

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46Novoseek, 3BitterDB, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1propylthiouracil46 3 1211.7PRTN3, MPO
2cytochalasin b469.7PRTN3, MPO
3n-formylmethionyl-leucylphenylalanine469.7MPO, PRTN3
4formaldehyde46 2510.6PRTN3, MPO
5fmlp469.6PRTN3, MPO
6valine469.6MPO, PRTN3
7dmso469.6PRTN3, MPO
8infliximab46 52 1211.5CRP, PRTN3
9rituximab46 52 1211.5CRP, PRTN3
10azathioprine46 3 52 1212.5CRP, PRTN3
11p002469.4CRP, PRTN3
12aopp469.4CRP, MPO
13d penicillamine469.4CRP, MPO
14sulfasalazine30 46 52 1212.4CRP, MPO
158-isoprostane469.4MPO, CRP
16methacholine46 52 1211.4CRP, MPO
17nadph46 2510.4PRTN3, MPO
18vitamin b12469.4CRP, MPO
19malondialdehyde469.4CRP, MPO
20polyethylene glycol469.4MPO, CRP
21clozapine46 30 52 1212.4CRP, MPO
22prednisolone46 30 1211.3MPO, CRP
23cyclophosphamide46 52 1211.3CRP, MPO
24chloramphenicol46 3 52 1212.3CRP, MPO
25n acetylcysteine469.2CRP, MPO
26ascorbic acid46 2510.2MPO, CRP
27acetylcholine46 52 30 25 1213.2CRP, MPO
28iron46 2510.0MPO, CRP
29creatinine469.0CRP, MPO
30superoxide46 2510.0PRTN3, MPO
31lactate468.9CRP, MPO
32calcium46 52 25 1211.6CRP, PRTN3, MPO

GO Terms for genes affiliated with Mononeuritis Multiplex

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17Gene Ontology
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Biological processes related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.0CRP, MPO

Products for genes affiliated with Mononeuritis Multiplex

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Sources for Mononeuritis Multiplex

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet