MCID: MNN002
MIFTS: 38

Mononeuritis Multiplex malady

Rare diseases, Neuronal diseases categories
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Summaries for Mononeuritis Multiplex

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Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards based summary: Mononeuritis Multiplex is related to polyarteritis nodosa and churg-strauss syndrome. An important gene associated with Mononeuritis Multiplex is MPO (myeloperoxidase), and among its related pathways are C-MYB transcription factor network and Selenium Pathway. The compounds propylthiouracil and cytochalasin b have been mentioned in the context of this disorder. Affiliated tissues include lung, b cells and heart, and related mouse phenotype immune system.

Aliases & Classifications for Mononeuritis Multiplex

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Mononeuritis Multiplex, Aliases & Descriptions:

Name: Mononeuritis Multiplex 8 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:1835
MeSH34 D020422
SNOMED-CT57 30292005
NCIt39 C70938
ICD9CM27 354.5

Related Diseases for Mononeuritis Multiplex

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Diseases related to Mononeuritis Multiplex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1polyarteritis nodosa30.8PRTN3, MPO
2churg-strauss syndrome30.8MPO, PRTN3
3vasculitis30.6CRP, PRTN3, MPO
4arthritis30.4MPO, CRP, PRTN3
5rheumatoid arthritis30.3CRP, PRTN3, MPO
6systemic lupus erythematosus30.3CRP, PRTN3, MPO
7hypersensitivity vasculitis30.3PRTN3, MPO
8mononeuropathy30.3MPO, PRTN3
9pancreatitis30.2MPO, CRP
10wegener's granulomatosis30.2PRTN3, MPO
11pneumonia30.2CRP, MPO
12eosinophilia30.2MPO, PRTN3
13acute leukemia30.0PRTN3, MPO
14asthma30.0PRTN3, MPO
15mononeuritis11.2
16hepatitis10.4
17leptospirosis10.4
18mediastinitis10.4CRP
19macroglobulinemia10.4
20leprosy10.4
21lupus erythematosus10.4
22chronic inflammatory demyelinating polyneuropathy10.3
23cryoglobulinemia10.3
24hepatitis a10.3
25lepromatous leprosy10.3
26demyelinating polyneuropathy10.3
27mononeuritis of upper limb and mononeuritis multiplex10.3
28neuropathy10.3
29polyneuropathy10.3
30purpura10.3
31hereditary neuralgic amyotrophy10.3
32reactive arthritis10.1PRTN3, CRP
33b-cell lymphomas10.1
34diabetes mellitus10.1
35hepatitis b10.1
36leukemia10.1
37malaria10.1
38myelodysplastic syndromes10.1
39myocardial infarction10.1
40non-small cell lung carcinoma10.1
41kimura disease10.1
42granulomatous angiitis10.1
43acalculous cholecystitis10.1
44plasmodium falciparum malaria10.1
45hepatitis c10.1
46scrub typhus10.1
47typhoid fever10.1
48central retinal artery occlusion10.1
49lyme disease10.1
50neurofibromatosis10.1

Graphical network of the top 20 diseases related to Mononeuritis Multiplex:



Diseases related to mononeuritis multiplex

Symptoms for Mononeuritis Multiplex

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Drugs & Therapeutics for Mononeuritis Multiplex

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Drug clinical trials:

Search ClinicalTrials for Mononeuritis Multiplex

Search NIH Clinical Center for Mononeuritis Multiplex

Genetic Tests for Mononeuritis Multiplex

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Anatomical Context for Mononeuritis Multiplex

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MalaCards organs/tissues related to Mononeuritis Multiplex:

32
Lung, B cells, Heart, Small intestine, Colon, Skin, Neutrophil

Animal Models for Mononeuritis Multiplex or affiliated genes

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MGI Mouse Phenotypes related to Mononeuritis Multiplex:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5CRP, PRTN3, MPO

Publications for Mononeuritis Multiplex

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Articles related to Mononeuritis Multiplex:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Mononeuritis multiplex predicts the need for immunosuppressive or immunomodulatory drugs for EGPA, PAN and MPA patients without poor-prognosis factors. (25153486)
2014
2
Paraneoplastic mononeuritis multiplex as a presenting feature of adenocarcinoma of the lung. (24455360)
2013
3
Livedoid Vasculopathy and Mononeuritis Multiplex, with a Fulminant Hepatic Failure which was caused by Herpes Simplex Hepatitis: A Case Report. (23814745)
2013
4
Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated C-reactive protein. (24303898)
2013
5
An unusual cause of mononeuritis multiplex. (23315459)
2013
6
De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha? (22679403)
2012
7
Mononeuritis multiplex complicating systemic lupus erythematosus. (22885442)
2012
8
A case of scrub typhus with acalculous cholecystitis, aseptic meningitis and mononeuritis multiplex. (21940653)
2012
9
Cutaneous large B-cell lymphoma of the leg: presenting initially as mononeuritis multiplex. (19495496)
2009
10
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
11
Adalimumab induced mononeuritis multiplex in a patient with refractory rheumatoid arthritis: a case report. (18973686)
2008
12
A purpuric rash and mononeuritis multiplex. (18326170)
2008
13
Case of mononeuritis multiplex onset with rituximab therapy for WaldenstrAPm's macroglobulinemia. (17537458)
2007
14
Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. (17401258)
2007
15
Presence of perineuritis in a case of papular purpuric gloves and socks syndrome associated with mononeuritis multiplex attributable to B19 parvovirus. (16635678)
2006
16
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
17
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. (12700924)
2003
18
Paediatric mononeuritis multiplex: a report of three cases and review of the literature. (14561499)
2003
19
Sensory perineuritis presented as a mononeuritis multiplex associated with livedo vasculitis. (11311480)
2001
20
Th2 shift in mononeuritis multiplex and increase of Th2 cells in chronic inflammatory demyelinating polyneuropathy: an intracellular cytokine analysis. (11718750)
2001
21
Neurolymphomatosis presenting as mononeuritis multiplex. (18639200)
1999
22
Horner's syndrome associated with mononeuritis multiplex due to cytomegalovirus as the initial manifestation in a patient with AIDS. (9543329)
1998
23
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
24
Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide. (8646231)
1996
25
Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. (7897423)
1995
26
Hypereosinophilic syndrome presenting as recurrent benign mononeuritis multiplex. (8088985)
1994
27
Mononeuritis multiplex. A harbinger of acute leukemia in relapse. (8198473)
1994
28
Mononeuritis multiplex and vasculitis. Association with anti-neutrophil cytoplasmic autoantibody. (8198467)
1994
29
Churg-Strauss syndrome (allergic granulomatous angiitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. (8012511)
1994
30
Mononeuritis multiplex in a child with cutaneous polyarteritis. (1348850)
1992
31
Case-of-the-month: perineuritis presenting as mononeuritis multiplex. (1584256)
1992
32
Mononeuritis multiplex associated with cryoglobulinemia in HIV infection. (1436518)
1992
33
Polyarthritis, mononeuritis multiplex and eczematous ulcerative skin rash in a patient with myelodysplastic syndrome and peripheral large granular lymphocytosis. (1722442)
1991
34
BehAset's disease presenting with mononeuritis multiplex [corrected]. (2177579)
1990
35
Mononeuritis multiplex in incomplete BehAset's disease: a case report and the review of the literature. (2680237)
1989
36
Mononeuritis multiplex as an unusual complication of leptospirosis. (2809239)
1989
37
Periarteritis nodosa with mononeuritis multiplex. (2878916)
1986
38
Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. (3728548)
1986
39
Mononeuritis multiplex following jellyfish stings. (6142678)
1984
40
Perineuritis in mononeuritis multiplex with cryoglobulinemia. (7070397)
1982
41
Lymphoma presenting as mononeuritis multiplex. (7329882)
1981
42
SjAPgren's syndrome and mononeuritis multiplex. (7350862)
1980
43
Mononeuritis multiplex due to haemorrhage. (638684)
1978
44
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
45
Mononeuritis multiplex occurring in a diabetic patient with Hb C disease. (4704497)
1973
46
Mononeuritis multiplex in lepromatous leprosy. (5690422)
1968
47
Mononeuritis multiplex in lepromatous leprosy. (4301578)
1968
48
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14144116)
1964
49
MONONEURITIS MULTIPLEX IN POLYARTERITIS NODOSA. (14045124)
1963
50
Heredofamilial mononeuritis multiplex with brachial predilection. (13837190)
1960

Variations for Mononeuritis Multiplex

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Expression for genes affiliated with Mononeuritis Multiplex

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Expression patterns in normal tissues for genes affiliated with Mononeuritis Multiplex

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Pathways for genes affiliated with Mononeuritis Multiplex

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Pathways related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PRTN3, MPO
2
Show member pathways
thioredoxin pathway37
9.0CRP, MPO

Compounds for genes affiliated with Mononeuritis Multiplex

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1111.7PRTN3, MPO
2cytochalasin b449.7PRTN3, MPO
3n-formylmethionyl-leucylphenylalanine449.7MPO, PRTN3
4formaldehyde44 2410.6PRTN3, MPO
5fmlp449.6PRTN3, MPO
6valine449.6MPO, PRTN3
7dmso449.6PRTN3, MPO
8infliximab44 50 1111.5CRP, PRTN3
9rituximab44 50 1111.5CRP, PRTN3
10azathioprine44 2 50 1112.5CRP, PRTN3
11p002449.4CRP, PRTN3
12aopp449.4CRP, MPO
13d penicillamine449.4CRP, MPO
14sulfasalazine28 44 50 1112.4CRP, MPO
158-isoprostane449.4MPO, CRP
16methacholine44 50 1111.4CRP, MPO
17nadph44 2410.4PRTN3, MPO
18vitamin b12449.4CRP, MPO
19malondialdehyde449.4CRP, MPO
20polyethylene glycol449.4MPO, CRP
21clozapine44 28 50 1112.4CRP, MPO
22prednisolone44 28 1111.3MPO, CRP
23cyclophosphamide44 50 1111.3CRP, MPO
24chloramphenicol44 2 50 1112.3CRP, MPO
25n acetylcysteine449.2CRP, MPO
26ascorbic acid44 2410.2MPO, CRP
27acetylcholine44 50 28 24 1113.2CRP, MPO
28iron44 2410.0MPO, CRP
29creatinine449.0CRP, MPO
30superoxide44 2410.0PRTN3, MPO
31lactate448.9CRP, MPO
32calcium44 50 24 1111.6CRP, PRTN3, MPO

GO Terms for genes affiliated with Mononeuritis Multiplex

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Biological processes related to Mononeuritis Multiplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1agingGO:0075689.0CRP, MPO

Products for genes affiliated with Mononeuritis Multiplex

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Sources for Mononeuritis Multiplex

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet