Mononeuritis Multiplex malady

Wikipedia: Peripheral neuropathy is damage to nerves of the peripheral nervous system, which may be caused either...⁴⁴ more...

MalaCards: Mononeuritis Multiplex, also known as mononeuritis multiplex (disorder), is related to mononeuritis and wegener's granulomatosis. An important gene associated with Mononeuritis Multiplex is PRTN3 (proteinase 3). The compounds infliximab and rituximab have been mentioned in the context of this disorder.

Aliases & Descriptions:

mononeuritis multiplex 6 30 32 43 mononeuritis multiplex (disorder) 6

Diseases related to mononeuritis multiplex by text searches and GeneDecks gene sharing:

(show top 50)    (show all 112)

id	Related Disease	Score	Top Affiliating Genes
1	mononeuritis	28.4	MPO, CRP, PRTN3
2	wegener's granulomatosis	28.4	MPO, CRP, PRTN3
3	vasculitis	28.3	PRTN3, CRP, MPO
4	relapsing polychondritis	12.8	CRP, PRTN3
5	ankylosing spondylitis	12.8	PRTN3, CRP
6	mixed connective tissue disease	12.8	PRTN3, CRP
7	reactive arthritis	12.8	PRTN3, CRP
8	respiratory failure	12.8	CRP, PRTN3
9	interstitial lung disease	12.7	CRP, PRTN3
10	cerebrovascular disease	12.7	PRTN3, CRP
11	urticaria	12.7	PRTN3, CRP
12	systolic heart failure	12.6	CRP, MPO
13	proctitis	12.6	MPO, CRP
14	aortic atherosclerosis	12.6	MPO, CRP
15	pelvic inflammatory disease	12.6	MPO, CRP
16	endocarditis	12.6	CRP, PRTN3
17	protein-energy malnutrition	12.6	CRP, MPO
18	adult respiratory distress syndrome	12.6	MPO, CRP
19	peripheral vascular disease	12.6	CRP, MPO
20	carotid stenosis	12.6	MPO, CRP
21	cerebral artery occlusion	12.6	CRP, MPO
22	pleurisy	12.6	CRP, MPO
23	brucellosis	12.6	CRP, MPO
24	fabry disease	12.6	MPO, CRP
25	bacterial meningitis	12.6	MPO, CRP
26	pulmonary embolism	12.6	MPO, CRP
27	appendicitis	12.6	CRP, MPO
28	chorioamnionitis	12.6	MPO, CRP
29	diabetes insipidus	12.6	CRP, MPO
30	nonalcoholic steatohepatitis	12.6	CRP, MPO
31	disseminated intravascular coagulation	12.6	CRP, MPO
32	pulmonary function	12.6	CRP, MPO
33	familial hypercholesterolemia	12.6	MPO, CRP
34	rapidly progressive glomerulonephritis	12.6	MPO, PRTN3
35	hypersensitivity vasculitis	12.6	PRTN3, MPO
36	leukopenia	12.6	CRP, MPO
37	polycythemia vera	12.6	MPO, CRP
38	mononeuropathy	12.6	PRTN3, MPO
39	hepatopulmonary syndrome	12.6	MPO, CRP
40	mediastinitis	12.5	MPO, CRP
41	bronchitis	12.5	MPO, PRTN3
42	otitis media	12.5	CRP, MPO
43	vascular disease	12.5	CRP, PRTN3
44	cerebrovascular accident	12.5	MPO, CRP
45	open-angle glaucoma	12.5	CRP, MPO
46	polycythemia	12.5	MPO, CRP
47	tetanus	12.5	CRP, MPO
48	acute promyelocytic leukemia	12.5	MPO, PRTN3
49	synovitis	12.5	CRP, MPO
50	primary sclerosing cholangitis	12.5	PRTN3, MPO

Approved drugs:

Drug clinical trials:

Articles related to mononeuritis multiplex:

id	Title	Authors	Year	Affiliating Genes
1	Orbital inflammatory pseudotumor due to hypersensitiv ity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-pos itive Wegener's granulomatosis. (12700924)	Kaufmann J.... Stein G.	2003	CRP

Genes related to mononeuritis multiplex according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PRTN3	proteinase 3	11.0
2	MPO	myeloperoxidase	11.0
3	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Compounds related to mononeuritis multiplex according to GeneDecks:

(show all 22)

id	Compound	Score	Top Affiliating Genes
1	infliximab32 9 9	11.6	CRP, PRTN3
2	rituximab32 34 9 9	12.6	PRTN3, CRP
3	azathioprine32 34 9 9	12.5	PRTN3, CRP
4	aopp32	9.5	MPO, CRP
5	p00232	9.5	CRP, PRTN3
6	d penicillamine32	9.5	CRP, MPO
7	sulfasalazine32 9 9	11.5	MPO, CRP
8	8-isoprostane32	9.5	MPO, CRP
9	methacholine32 9 9	11.4	MPO, CRP
10	vitamin b1232	9.4	MPO, CRP
11	malondialdehyde32	9.4	MPO, CRP
12	propylthiouracil32 9 9	11.4	PRTN3, MPO
13	clozapine32 34 9 9	12.4	MPO, CRP
14	cytochalasin b32	9.3	PRTN3, MPO
15	polyethylene glycol32	9.3	MPO, CRP
16	n-formylmethionyl-leucylphenylalanine32	9.3	PRTN3, MPO
17	prednisolone32 9 9	11.2	CRP, MPO
18	cyclophosphamide32 34 9 9	12.2	MPO, CRP
19	formaldehyde32 18	10.0	MPO, PRTN3
20	dmso32	9.0	MPO, PRTN3
21	fmlp32	8.9	PRTN3, MPO
22	valine32	8.7	MPO, PRTN3