MCID: MNN017
MIFTS: 35

Mononeuropathy malady

Neuronal category

Summaries for Mononeuropathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Mononeuropathy, also known as mononeuropathies, is related to vasculitis and carpal tunnel syndrome. An important gene associated with Mononeuropathy is SH3TC2 (SH3 domain and tetratricopeptide repeats 2). The compounds propylthiouracil and valine have been mentioned in the context of this disorder.

Aliases & Classifications for Mononeuropathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Mononeuropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.4APOH, PRTN3, IFNA2, MPO
2carpal tunnel syndrome30.3PMP22, TTR
3hepatitis c30.3IFNA2, PRTN3
4churg-strauss syndrome30.0MPO, PRTN3
5mononeuritis multiplex29.8PRTN3, MPO
6ulcerative colitis29.8GAL, MPO, PRTN3
7systemic lupus erythematosus29.8APOH, MPO, PRTN3
8hepatitis a10.2
9mononeuropathy of the median nerve, mild10.2
10cryoglobulinemia10.1
11n syndrome10.1
12radiculopathy10.0
13radial nerve lesion10.0
14median neuropathy10.0
15pain disorder10.0
16multifocal motor neuropathy10.0
17chronic pain10.0
18spinal cord injury10.0
19diabetes mellitus10.0PMP22
20neuritis10.0PMP22
21hereditary neuropathy with liability to pressure palsies10.0PMP22
22degos disease10.0APOH
23pulmonary embolism10.0APOH
24endocarditis10.0PRTN3
25retinal vasculitis10.0APOH
26alpha 1-antitrypsin deficiency10.0PRTN3
27lupus erythematosus10.0APOH
28acute pancreatitis10.0MPO
29pancreatitis10.0MPO
30graves' disease10.0MPO
31stomach cancer10.0FSCN1
32diarrhea10.0TTR
33hypothyroidism10.0TTR
34syphilis10.0APOH
35papilloma10.0FSCN1
36viral hepatitis10.0IFNA2
37pneumonia10.0MPO
38hepatitis b10.0IFNA2
39kidney cancer10.0IFNA2
40inflammatory bowel disease10.0MPO
41protein-energy malnutrition10.0TTR
42adenocarcinoma10.0FSCN1, GAL
43insulin resistance10.0TTR
44hyperthyroidism10.0PRTN3, GAL
45conjunctivitis10.0IGHE
46urticaria10.0IGHE
47uveitis10.0GAL, IFNA2
48rapidly progressive glomerulonephritis10.0MPO, PRTN3
49hypersensitivity vasculitis10.0MPO, PRTN3
50peritonitis10.0PRTN3, MPO

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to mononeuropathy

Clinical Features for Mononeuropathy

Drugs & Therapeutics for Mononeuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mononeuropathy

Drug clinical trials:

Search ClinicalTrials for Mononeuropathy

Search NIH Clinical Center for Mononeuropathy

Search CenterWatch for Mononeuropathy

Genetic Tests for Mononeuropathy

Anatomical Context for Mononeuropathy

Animal Models for Mononeuropathy or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mononeuropathy

Sources:
51PubMed
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Articles related to Mononeuropathy:

(show top 50)    (show all 310)
idTitleAuthorsYear
1
Ultrasound diagnosis of peroneal nerve variant in a child with compressive mononeuropathy. (21292098)
2011
2
Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833. (19345493)
2009
3
Histological and ultrastructural evidence that recurrent laryngeal neuropathy is a bilateral mononeuropathy limited to recurrent laryngeal nerves. (19165936)
2008
4
Clinical and neurophysiological study of peroneal nerve mononeuropathy after substantial weight loss in patients suffering from major depressive and schizophrenic disorder: Suggestions on patients' management. (19014507)
2008
5
Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. (18565660)
2008
6
Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy. (17383023)
2007
7
Treatment for diabetic mononeuropathy with alpha-lipoic acid. (15924591)
2005
8
Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy. (15894010)
2005
9
Multicenter study of peroneal mononeuropathy: clinical, neurophysiologic, and quality of life assessment. (16221285)
2005
10
Upper extremity mononeuropathy among engineers. (16340709)
2005
11
Cigarette smoking and ulnar mononeuropathy at the elbow. (15314539)
2004
12
Small fibers peroneal mononeuropathy in a patient with SjAPgren's syndrome. (15481820)
2004
13
The effects of aging on thermal hyperalgesia and tactile-evoked allodynia using two models of peripheral mononeuropathy in the rat. (12614905)
2003
14
Idiopathic thrombocytopenic purpura and mononeuropathy multiplex. (12975555)
2003
15
Activation of diffuse noxious inhibitory controls (DNIC) in rats with an experimental peripheral mononeuropathy. (11275386)
2001
16
Isolated Rosai-Dorfman disease presenting as peripheral mononeuropathy and clinically mimicking a neurogenic tumor: case report. (11750016)
2001
17
Isolated femoral mononeuropathy in the athlete. Anatomic considerations and report of two cases. (11734499)
2001
18
Dorsal column-thalamic pathway is involved in thalamic hyperexcitability following peripheral nerve injury: a lesion study in rats with experimental mononeuropathy. (10692627)
2000
19
Catamenial mononeuropathy and radiculopathy. (9950514)
1999
20
Iatrogenic superior gluteal mononeuropathy. (9843087)
1998
21
Differential effects of intrathecally administered N- and P-type voltage-sensitive calcium channel blockers upon two models of experimental mononeuropathy in the rat. (9622667)
1998
22
Zidovudine and human immunodeficiency virus-associated peripheral neuropathies: low intake in patients with mononeuropathy multiplex and no evidence for neurotoxicity. (8995592)
1997
23
The effect of a peripheral mononeuropathy on immunoreactive (ir)-galanin release in the spinal cord of the rat. (9359612)
1997
24
An unusual presentation of a traumatic ulnar mononeuropathy with a Martin-Gruber anastomosis. (8965853)
1996
25
Frequency of median mononeuropathy in patients with mild diabetic neuropathy in the early diabetes intervention trial (EDIT). Tolrestat Study Group For Edit (Early Diabetes Intervention Trial) (8559161)
1996
26
Pediatric ulnar mononeuropathy: report of 21 electromyography-documented cases and review of the literature. (8881988)
1996
27
Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy. (8592645)
1995
28
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy. (7596623)
1995
29
Acute multiple mononeuropathy after accidental exposure to oven microwaves. (7579305)
1995
30
Peri-administration of clonidine or MK801 delays but does not prevent the development of mechanical hyperalgesia in a model of mononeuropathy in the rat. (7675304)
1995
31
Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. (7493620)
1995
32
Tibial mononeuropathy from a lower limb synovial cyst. (8599778)
1995
33
Responses of neurons in the ventrolateral orbital cortex to noxious cutaneous stimulation in a rat model of peripheral mononeuropathy. (8205486)
1994
34
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. (8385540)
1993
35
Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. (1319790)
1992
36
Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy. (1311824)
1992
37
Mononeuropathy in sickle cell anemia: anatomical and pathophysiological basis for its rarity. (1851248)
1991
38
Common peroneal mononeuropathy: a clinical and electrophysiologic study of 116 lesions. (2847078)
1988
39
Proximal ulnar mononeuropathy caused by conduction block at Erb's point. (2833209)
1988
40
AAEE case report #12: Common peroneal mononeuropathy at the fibular head. (3023997)
1986
41
Mononeuropathy multiplex (AAEE case report #11). (16758572)
1985
42
Concurrent Bell's palsy and diabetes mellitus: a diabetic mononeuropathy? (7119834)
1982
43
Hypertrophic mononeuropathy. A report of two cases and review of the literature. (6289772)
1982
44
DFP mononeuropathy: evidence for a peripheral site of initiation. (7357425)
1980
45
Mononeuropathy. (184527)
1976
46
Mononeuropathy multiplex as a complication of amphetamine angiitis. (165440)
1975
47
Transient cranial mononeuropathy. (4347338)
1972
48
Idiopathic palsy of the recurrent laryngeal nerve: a transient cranial mononeuropathy. (5083885)
1972
49
Ischemic mononeuropathy and mononeuropathy multiplex in diabetes mellitus. (4297979)
1968
50
Benign neurologic disorders. Part 2. Sensory mononeuropathy. (13833483)
1960

Genetic Variations for Mononeuropathy

Expression for genes affiliated with Mononeuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuropathy

Search GEO for disease gene expression data for Mononeuropathy.

Pathways for genes affiliated with Mononeuropathy

Compounds for genes affiliated with Mononeuropathy

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Mononeuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 2 1112.5APOH
2valine4510.5TTR
3hydroxychloroquine45 1111.0IFNA2, APOH
4aopp4510.0MPO, APOH
5trifluoroethanol45 1111.0GAL, TTR
6megestrol acetate459.9IFNA2, TTR
7chlorine45 2410.9TTR, IGHE
8procainamide45 1110.9APOH, MPO
92-methoxyethanol459.8IFNA2, IGHE
10ticlopidine45 1110.8MPO, APOH
11steroidal459.8PMP22, GAL
12levamisole45 1110.8IGHE, IFNA2
13galactose459.7GAL, APOH, IFNA2
14dapsone2 45 50 1112.7IFNA2, MPO
15taurine45 60 2411.7GAL, MPO
16betacarotene459.7TTR, APOH, IFNA2
17alpha tocopherol459.6IFNA2, APOH, TTR
18allopurinol45 50 1111.6MPO, IFNA2
19vitamin b12459.6APOH, MPO, TTR
20octreotide45 60 29 1112.6MPO, GAL, IFNA2
21polyacrylamide459.5TTR, GAL, APOH
22folate459.5TTR, IGHE, APOH
23thyroxine45 2410.4TTR, IGHE, IFNA2
245fluorouracil459.4MPO, GAL, IFNA2
25vitamin a45 11 2411.3IFNA2, IGHE, TTR
26rituximab45 50 1111.2PRTN3, APOH, IFNA2
27azathioprine45 50 2 1112.2PRTN3, APOH, IFNA2
28gold459.2IFNA2, APOH, PRTN3
29epinephrine45 11 2411.2IFNA2, GAL, IGHE, TTR
30budesonide45 50 1111.1IGHE, MPO
31aspartate459.1PMP22, IFNA2, IGHE, TTR
32formaldehyde45 2410.1GAL, MPO, PRTN3
33fmlp459.1GAL, MPO, PRTN3
34prednisolone45 29 1111.0IFNA2, APOH, MPO, IGHE
35histamine45 29 2411.0IFNA2, GAL, MPO, IGHE
36cyclophosphamide45 50 1111.0IFNA2, APOH, MPO, IGHE
37lactate459.0APOH, MPO, IGHE, TTR
38creatinine459.0TTR, IGHE, MPO, APOH
39indomethacin45 60 29 1112.0IGHE, MPO, IFNA2
40phosphatidylserine45 29 1111.0APOH, GAL, PRTN3, TTR
41arginine458.9PMP22, APOH, GAL, IGHE, TTR
42iron45 249.8TTR, MPO, GAL, APOH, IFNA2
43infliximab45 50 1110.7IFNA2, APOH, PRTN3, IGHE
44ascorbic acid45 249.7PMP22, IFNA2, MPO, IGHE, TTR
45superoxide45 249.7PRTN3, MPO, APOH, IFNA2
46vegf458.5IFNA2, APOH, MPO, IGHE
47alanine458.3IFNA2, GAL, PRTN3, IGHE, TTR
48serine458.2PMP22, GAL, MPO, PRTN3, FSCN1
49estrogen458.0IFNA2, APOH, GAL, PRTN3, IGHE, TTR
50retinoic acid45 247.9TTR, PMP22, IFNA2, GAL, MPO, PRTN3

GO Terms for genes affiliated with Mononeuropathy

Products for genes affiliated with Mononeuropathy

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  • Proteins
  • Lysates
  • Antibodies

Sources for Mononeuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet