MCID: MNN017
MIFTS: 45

Mononeuropathy malady

Neuronal diseases category
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Summaries for Mononeuropathy

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards: Mononeuropathy, also known as mononeuropathies, is related to neuropathy and vasculitis. An important gene associated with Mononeuropathy is SH3TC2 (SH3 domain and tetratricopeptide repeats 2), and among its related pathways is C-MYB transcription factor network. The compounds steroidal and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and breast.

Aliases & Classifications for Mononeuropathy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Mononeuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.6PMP22, SH3TC2
2vasculitis30.3APOH, MPO, PRTN3, IFNA2
3polyneuropathy30.2PMP22, IFNA2
4cryoglobulinemia30.2IFNA2, APOH
5endocarditis30.2PRTN3
6churg-strauss syndrome30.1MPO, PRTN3
7eosinophilia30.0IGHE, MPO, PRTN3, IFNA2
8hyperthyroidism29.9GAL, PRTN3
9lupus erythematosus29.9APOH, IFNA2
10mononeuritis multiplex29.9MPO, PRTN3
11wegener's granulomatosis29.8PRTN3, MPO
12peritonitis29.8MPO, PRTN3
13ulcerative colitis29.8MPO, PRTN3, GAL
14systemic lupus erythematosus29.8APOH, MPO, PRTN3
15asthma29.7IGHE, MPO, PRTN3
16diabetes mellitus10.4
17neuronitis10.4
18hepatitis10.3
19carpal tunnel syndrome10.3
20purpura10.2
21hepatitis c10.2
22diabetic neuropathy10.2
23mononeuropathy of the median nerve, mild10.2
24hepatitis b10.1
25radial nerve lesion10.1
26laryngitis10.1
27charcot-marie-tooth disease10.1PMP22
28degos disease10.1APOH
29retinal vasculitis10.1APOH
30bronchiolitis10.1IGHE
31rhinitis10.1IGHE
32mixed connective tissue disease10.1PRTN3, APOH
33sinusitis10.1IGHE, PRTN3
34sjogren's syndrome10.0PRTN3, APOH
35mastocytosis10.0IFNA2, IGHE
36bell's palsy10.0
37causalgia10.0
38radiculopathy10.0
39cerebritis10.0
40breast cancer10.0
41complex regional pain syndrome10.0
42radial neuropathy10.0
43sarcoma10.0
44b-cell lymphomas10.0
45chronic pain10.0
46rapidly progressive glomerulonephritis10.0MPO, PRTN3
47behcet's disease10.0APOH, IFNA2
48uveitis10.0GAL, IFNA2
49hypersensitivity vasculitis10.0PRTN3, MPO
50hemolytic anemia10.0IFNA2, APOH

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to mononeuropathy

Symptoms for Mononeuropathy

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Drugs & Therapeutics for Mononeuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Mononeuropathy

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Anatomical Context for Mononeuropathy

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33MalaCards
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MalaCards organs/tissues related to Mononeuropathy:

33
Spinal cord, Cortex, Breast, Skin, Brain, B cells, Testes, Hypothalamus

Animal Models for Mononeuropathy or affiliated genes

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Publications for Mononeuropathy

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52PubMed
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Articles related to Mononeuropathy:

(show top 50)    (show all 308)
idTitleAuthorsYear
1
Ultrasound diagnosis of peroneal nerve variant in a child with compressive mononeuropathy. (21292098)
2011
2
Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome. (21287183)
2011
3
Saphenous mononeuropathy after popliteal vein aneurysm repair. (20065798)
2010
4
Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists. (19285491)
2009
5
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
6
Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report. (19920803)
2009
7
Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. (18343581)
2008
8
Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy. (17383023)
2007
9
Diagnosis and management of "an apparent mechanical" femoral mononeuropathy: a case study. (18060007)
2007
10
A case of mononeuropathy multiplex with type II cryoglobulinemia, necrotizing vasculitis and low grade B cell lymphoma. (17290934)
2007
11
Mononeuropathy following subcutaneous interferon-beta injection. (16511643)
2006
12
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. (15932604)
2005
13
Italian multicentre study of peroneal mononeuropathy at the fibular head: study design and preliminary results. (15830970)
2005
14
Treatment concepts for idiopathic and iatrogenic femoral nerve mononeuropathy. (16186707)
2005
15
Simvastatin-induced mononeuropathy multiplex: case report. (15273860)
2004
16
The effects of aging on thermal hyperalgesia and tactile-evoked allodynia using two models of peripheral mononeuropathy in the rat. (12614905)
2003
17
Electrodiagnostic approach to the patient with suspected mononeuropathy of the upper extremity. (12152443)
2002
18
The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model. (14622739)
2002
19
Proximal median mononeuropathy associated with an anomalous deep course through the brachialis muscle. (11032638)
2000
20
Posterior femoral cutaneous nerve mononeuropathy: a case report. (10943764)
2000
21
Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy. (10678779)
2000
22
MRI in unexplained mononeuropathy. (10788751)
2000
23
Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. (10068168)
1999
24
Mononeuropathy multiplex in hemophilia: an electrophysiologic assessment. (9693226)
1998
25
Isolated trigeminal nerve metastases from breast cancer: an unusual cause of trigeminal mononeuropathy. (9586936)
1998
26
Iatrogenic superior gluteal mononeuropathy. (9843087)
1998
27
Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. (9395132)
1997
28
A case-control and nerve biopsy study of CREST multiple mononeuropathy. (9409360)
1997
29
Mononeuropathy of a distal branch of the femoral nerve in a body building champion. (9408112)
1997
30
HIV related vasculitic mononeuropathy multiplex: a role for IVIg? (9285470)
1997
31
Complex regional pain syndrome type I (RSD) or peripheral mononeuropathy? A discussion of three cases. (8776555)
1996
32
An unusual presentation of a traumatic ulnar mononeuropathy with a Martin-Gruber anastomosis. (8965853)
1996
33
Mononeuropathy multiplex cranialis in a case of non-Hodgkin's lymphoma mistaken as paraneoplastic syndrome. (9053419)
1995
34
Femoral mononeuropathy induced by the lithotomy position: a report of 5 cases with a review of literature. (8355719)
1993
35
Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy. (1325244)
1992
36
Primary somatosensory cortex in rats with pain-related behaviours due to a peripheral mononeuropathy after moderate ligation of one sciatic nerve: neuronal responsivity to somatic stimulation. (1337325)
1992
37
Mononeuropathy multiplex complicating idiopathic thrombocytopenic purpura. (1653915)
1991
38
A model of peripheral mononeuropathy in the rat. (2174143)
1990
39
Immediate improvement of diabetic mononeuropathy after intravenous administration of prostaglandin E1. (2232371)
1990
40
Mononeuropathy associated with hyperthyroidism. (1963442)
1990
41
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
42
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. (2837713)
1988
43
Compressive mononeuropathy of the deep palmar branch of the ulnar nerve in cyclists. (2851643)
1988
44
Mononeuropathy multiplex (AAEE case report #11). (16758572)
1985
45
Concurrent Bell's palsy and diabetes mellitus: a diabetic mononeuropathy? (7119834)
1982
46
DFP mononeuropathy: evidence for a peripheral site of initiation. (7357425)
1980
47
Diabetic truncal mononeuropathy--a new clinical syndrome. (554781)
1978
48
Mononeuropathy. (184527)
1976
49
Hypertrophic mononeuropathy. (4360401)
1974
50
Ischemic mononeuropathy multiplex associated with diabetes mellitus. (5647941)
1968

Variations for Mononeuropathy

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Expression for genes affiliated with Mononeuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuropathy

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Pathways for genes affiliated with Mononeuropathy

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Mononeuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0PRTN3, MPO

Compounds for genes affiliated with Mononeuropathy

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Mononeuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1steroidal4510.0PMP22, GAL
2hydroxychloroquine45 1110.9IFNA2, APOH
32-methoxyethanol459.8IFNA2, IGHE
4aopp459.8MPO, APOH
5levamisole45 1110.8IFNA2, IGHE
6salbutamol45 51 29 24 1113.8IGHE, GAL
7procainamide45 1110.8APOH, MPO
8ticlopidine45 1110.7MPO, APOH
9taurine45 61 2411.7MPO, GAL
10allopurinol45 51 1111.7MPO, IFNA2
11dapsone45 3 51 1112.7IFNA2, MPO
128-isoprostane459.6APOH, MPO
13etanercept45 51 1111.6IFNA2, APOH
14budesonide45 51 1111.6IGHE, MPO
15methimazole45 3 1111.6APOH, MPO
16fluticasone propionate45 51 61 1112.6IGHE, MPO
17methanol45 2410.5MPO, APOH
18galactose459.5GAL, IFNA2, APOH
19leucovorin45 51 1111.4IFNA2, GAL
20cardiolipin45 1110.4PRTN3, APOH
21mitoxantrone45 51 1111.4IFNA2, MPO
22epinephrine45 24 1111.4GAL, IFNA2, IGHE
23octreotide45 61 29 1112.4GAL, IFNA2, MPO
245fluorouracil459.3GAL, IFNA2, MPO
25acetylcholine45 51 29 24 1113.2GAL, MPO, IGHE
26phosphatidylserine45 29 1111.2GAL, PRTN3, APOH
27indomethacin45 29 61 1112.1IFNA2, MPO, IGHE
28rituximab45 51 1111.1IFNA2, PRTN3, APOH
29azathioprine45 3 51 1112.1APOH, PRTN3, IFNA2
30arginine459.1IGHE, PMP22, APOH, GAL
31gold459.1IFNA2, PRTN3, APOH
32cytochalasin b459.0MPO, PRTN3
33formaldehyde45 2410.0MPO, PRTN3, GAL
34propylthiouracil45 3 1111.0PRTN3, MPO, APOH
35fmlp459.0GAL, PRTN3, MPO
36iron45 249.9APOH, MPO, IFNA2, GAL
37ascorbic acid45 249.9IGHE, PMP22, MPO, IFNA2
38histamine45 29 2410.8IGHE, MPO, IFNA2, GAL
39prednisolone45 29 1110.8IGHE, APOH, MPO, IFNA2
40cyclophosphamide45 51 1110.8IGHE, APOH, MPO, IFNA2
41vegf458.7IGHE, APOH, MPO, IFNA2
42infliximab45 51 1110.6IFNA2, PRTN3, APOH, IGHE
43alanine458.6IGHE, PRTN3, IFNA2, GAL
44valine458.5IFNA2, PRTN3, MPO, APOH
45superoxide45 249.5APOH, MPO, PRTN3, IFNA2
46oxygen45 249.4APOH, MPO, PRTN3, IFNA2
47nadph45 249.3GAL, PRTN3, MPO
48lipid458.3GAL, IFNA2, PRTN3, APOH
49estrogen458.2IGHE, APOH, PRTN3, IFNA2, GAL
50retinoic acid45 248.7IGHE, PMP22, MPO, PRTN3, IFNA2, GAL

GO Terms for genes affiliated with Mononeuropathy

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16Gene Ontology
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Cellular components related to Mononeuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4GAL, MPO

Products for genes affiliated with Mononeuropathy

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Sources for Mononeuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet