MCID: MNN017
MIFTS: 43

Mononeuropathy malady

Neuronal diseases category

Summaries for Mononeuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Mononeuropathy, also known as mononeuropathies, is related to diabetes mellitus and neuropathy. An important gene associated with Mononeuropathy is SH3TC2 (SH3 domain and tetratricopeptide repeats 2). The compounds propylthiouracil and valine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and skin.

Aliases & Classifications for Mononeuropathy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Mononeuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.5PMP22
2neuropathy30.5PMP22, SH3TC2, TTR
3hepatitis30.3IFNA2, GAL, TTR
4carpal tunnel syndrome30.3PMP22, TTR
5vasculitis30.3IFNA2, APOH, MPO, PRTN3
6hepatitis c30.2PRTN3, IFNA2
7hepatitis b30.1IFNA2
8polyneuropathy30.1PMP22, IFNA2, TTR
9eosinophilia30.1IGHE, PRTN3, MPO, IFNA2
10endocarditis30.0PRTN3
11churg-strauss syndrome29.9PRTN3, MPO
12breast cancer29.9FSCN1, PRTN3, GAL
13hereditary neuropathy with liability to pressure palsies29.7PMP22
14lupus erythematosus29.7APOH
15hyperthyroidism29.7GAL, PRTN3
16mononeuritis multiplex29.7MPO, PRTN3
17peritonitis29.7PRTN3, MPO
18wegener's granulomatosis29.7MPO, PRTN3
19ulcerative colitis29.7PRTN3, MPO, GAL
20systemic lupus erythematosus29.7PRTN3, MPO, APOH
21neuronitis10.3
22diabetic neuropathy10.2
23purpura10.2
24mononeuropathy of the median nerve, mild10.1
25cryoglobulinemia10.1
26radial nerve lesion10.1
27hepatitis a10.1
28laryngitis10.1
29bell's palsy10.0
30causalgia10.0
31radiculopathy10.0
32cerebritis10.0
33median neuropathy10.0
34pain disorder10.0
35chronic polyneuropathy10.0
36complex regional pain syndrome10.0
37lesion of sciatic nerve10.0
38radial neuropathy10.0
39sarcoma10.0
40neuritis10.0PMP22
41degos disease10.0APOH
42pulmonary embolism10.0APOH
43retinal vasculitis10.0APOH
44alpha 1-antitrypsin deficiency10.0PRTN3
45acute pancreatitis10.0MPO
46pancreatitis10.0MPO
47graves' disease10.0MPO
48stomach cancer10.0FSCN1
49diarrhea10.0TTR
50hypothyroidism10.0TTR

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to mononeuropathy

Clinical Features for Mononeuropathy

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Drugs & Therapeutics for Mononeuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mononeuropathy

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Anatomical Context for Mononeuropathy

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32MalaCards
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MalaCards organs/tissues related to Mononeuropathy:

32
Spinal cord, Cortex, Skin, Brain, Breast, B cells, Testes, Hypothalamus

Animal Models for Mononeuropathy or affiliated genes

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Publications for Mononeuropathy

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Sources:
50PubMed
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Articles related to Mononeuropathy:

(show top 50)    (show all 314)
idTitleAuthorsYear
1
Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy. (23881562)
2014
2
Isolated cranial mononeuropathy: an unusual initial presentation and disease progression of metastatic carcinoma of the breast. (23669219)
2013
3
Electrodiagnostic evaluation of ulnar neuropathy and other upper extremity mononeuropathies. (22361371)
2012
4
Isolated mononeuropathy multiplex--a rare manifestation of intravascular large B-cell lymphoma. (22922577)
2012
5
Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. (21525272)
2011
6
Unilateral Abducens Nerve Palsy as an Early Feature of Multiple Mononeuropathy Associated with Anti-GQ1b Antibody. (21490718)
2011
7
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
8
An adult case of Henoch-SchAPnlein purpura complicating common peroneal nerve mononeuropathy. (18810313)
2009
9
Pain relief by spinal cord stimulation involves serotonergic mechanisms: an experimental study in a rat model of mononeuropathy. (19836134)
2009
10
Italian multicentre study of peroneal mononeuropathy: multiperspective follow-up. (19153647)
2009
11
Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. (18565660)
2008
12
Pseudoaneurysm of the popliteal artery complicated by peroneal mononeuropathy in a 4-year-old child: report of a case. (17713737)
2007
13
Multiple mononeuropathy due to vasculitis associated with anticardiolipin antibodies: a case report. (16823697)
2006
14
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. (15932604)
2005
15
Italian multicentre study of peroneal mononeuropathy at the fibular head: study design and preliminary results. (15830970)
2005
16
Upper extremity mononeuropathy among engineers. (16340709)
2005
17
Small fibers peroneal mononeuropathy in a patient with SjAPgren's syndrome. (15481820)
2004
18
Reduced tolerance to the anti-hyperalgesic effect of methadone in comparison to morphine in a rat model of mononeuropathy. (11790472)
2002
19
Confluent peripheral multiple mononeuropathy associated to acute hepatitis B: a case report. (12163912)
2002
20
Activation of diffuse noxious inhibitory controls (DNIC) in rats with an experimental peripheral mononeuropathy. (11275386)
2001
21
Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat. (10899286)
2000
22
Antinociceptive effects of neurotropin in a rat model of painful peripheral mononeuropathy. (9496714)
1998
23
Spinal neuron sensitization facilitates contralateral input in rats with peripheral mononeuropathy. (9507937)
1998
24
Differential effects of intrathecally administered N- and P-type voltage-sensitive calcium channel blockers upon two models of experimental mononeuropathy in the rat. (9622667)
1998
25
Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. (9395132)
1997
26
A case-control and nerve biopsy study of CREST multiple mononeuropathy. (9409360)
1997
27
HIV related vasculitic mononeuropathy multiplex: a role for IVIg? (9285470)
1997
28
Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism. (9414060)
1997
29
Frequency of median mononeuropathy in patients with mild diabetic neuropathy in the early diabetes intervention trial (EDIT) (8874414)
1996
30
Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat. (8884788)
1996
31
Frequency of median mononeuropathy in patients with mild diabetic neuropathy in the early diabetes intervention trial (EDIT). Tolrestat Study Group For Edit (Early Diabetes Intervention Trial) (8559161)
1996
32
Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. (8981434)
1996
33
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy. (7596623)
1995
34
Acute multiple mononeuropathy after accidental exposure to oven microwaves. (7579305)
1995
35
Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. (7493620)
1995
36
Tibial mononeuropathy from a lower limb synovial cyst. (8599778)
1995
37
Infrared laser diode irradiation has no behavioral or biochemical effect on pain in the sciatic nerve ligation-induced mononeuropathy in rat. (8934959)
1994
38
Responses of neurons in the ventrolateral orbital cortex to noxious cutaneous stimulation in a rat model of peripheral mononeuropathy. (8205486)
1994
39
Femoral mononeuropathy induced by the lithotomy position: a report of 5 cases with a review of literature. (8355719)
1993
40
Skin vascular reactivity to the neuropeptide substance P in rats with peripheral mononeuropathy. (7681162)
1993
41
Influence of an experimental peripheral mononeuropathy on the responses of medial bulboreticular neurons to noxious skin stimulation and the modulation of the responses by an alpha 2-adrenoceptor agonist in the rat. (7904570)
1993
42
Mononeuropathy in sickle cell anemia: anatomical and pathophysiological basis for its rarity. (1851248)
1991
43
Embolic mononeuropathy in subacute bacterial endocarditis. (2208826)
1990
44
Compressive mononeuropathy of the deep palmar branch of the ulnar nerve in cyclists. (2851643)
1988
45
Sciatic endometriosis: a treatable sensorimotor mononeuropathy. (3762945)
1986
46
Multiple mononeuropathy and hypereosinophilia. (3785287)
1986
47
Mononeuropathy in diabetes mellitus. (217792)
1979
48
Transient cranial mononeuropathy. (4347338)
1972
49
Idiopathic palsy of the recurrent laryngeal nerve: a transient cranial mononeuropathy. (5083885)
1972
50
Ischemic mononeuropathy multiplex associated with diabetes mellitus. (5647941)
1968

Genetic Variations for Mononeuropathy

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Expression for genes affiliated with Mononeuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mononeuropathy

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Pathways for genes affiliated with Mononeuropathy

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Compounds for genes affiliated with Mononeuropathy

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Mononeuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.5APOH
2valine4410.5TTR
3hydroxychloroquine44 1111.0IFNA2, APOH
4aopp4410.0MPO, APOH
5trifluoroethanol44 1111.0GAL, TTR
6megestrol acetate449.9IFNA2, TTR
7chlorine44 2410.9TTR, IGHE
8procainamide44 1110.9APOH, MPO
92-methoxyethanol449.8IFNA2, IGHE
10ticlopidine44 1110.8MPO, APOH
11steroidal449.8PMP22, GAL
12levamisole44 1110.8IGHE, IFNA2
13galactose449.7GAL, APOH, IFNA2
14dapsone2 44 49 1112.7IFNA2, MPO
15taurine44 59 2411.7GAL, MPO
16betacarotene449.7TTR, APOH, IFNA2
17alpha tocopherol449.6IFNA2, APOH, TTR
18allopurinol44 49 1111.6MPO, IFNA2
19vitamin b12449.6APOH, MPO, TTR
20octreotide44 59 28 1112.6MPO, GAL, IFNA2
21polyacrylamide449.5TTR, GAL, APOH
22folate449.5TTR, IGHE, APOH
23thyroxine44 2410.4TTR, IGHE, IFNA2
245fluorouracil449.4MPO, GAL, IFNA2
25vitamin a44 11 2411.3IFNA2, IGHE, TTR
26rituximab44 49 1111.2PRTN3, APOH, IFNA2
27azathioprine44 49 2 1112.2PRTN3, APOH, IFNA2
28gold449.2IFNA2, APOH, PRTN3
29epinephrine44 11 2411.2IFNA2, GAL, IGHE, TTR
30budesonide44 49 1111.1IGHE, MPO
31aspartate449.1PMP22, IFNA2, IGHE, TTR
32formaldehyde44 2410.1GAL, MPO, PRTN3
33fmlp449.1GAL, MPO, PRTN3
34prednisolone44 28 1111.0IFNA2, APOH, MPO, IGHE
35histamine44 28 2411.0IFNA2, GAL, MPO, IGHE
36cyclophosphamide44 49 1111.0IFNA2, APOH, MPO, IGHE
37lactate449.0APOH, MPO, IGHE, TTR
38creatinine449.0TTR, IGHE, MPO, APOH
39indomethacin44 59 28 1112.0IGHE, MPO, IFNA2
40phosphatidylserine44 28 1111.0APOH, GAL, PRTN3, TTR
41arginine448.9PMP22, APOH, GAL, IGHE, TTR
42iron44 249.8TTR, MPO, GAL, APOH, IFNA2
43infliximab44 49 1110.7IFNA2, APOH, PRTN3, IGHE
44ascorbic acid44 249.7PMP22, IFNA2, MPO, IGHE, TTR
45superoxide44 249.7PRTN3, MPO, APOH, IFNA2
46vegf448.5IFNA2, APOH, MPO, IGHE
47alanine448.3IFNA2, GAL, PRTN3, IGHE, TTR
48serine448.2PMP22, GAL, MPO, PRTN3, FSCN1
49estrogen448.0IFNA2, APOH, GAL, PRTN3, IGHE, TTR
50retinoic acid44 247.9TTR, PMP22, IFNA2, GAL, MPO, PRTN3

GO Terms for genes affiliated with Mononeuropathy

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Products for genes affiliated with Mononeuropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mononeuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet