MCID: MNN017
MIFTS: 39

Mononeuropathy malady

Neuronal diseases category

Summaries for Mononeuropathy

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Wikipedia:63 Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation,... more...

MalaCards based summary: Mononeuropathy, also known as mononeuropathies, is related to endocarditis and neuropathy. An important gene associated with Mononeuropathy is SH3TC2 (SH3 domain and tetratricopeptide repeats 2), and among its related pathways is C-MYB transcription factor network. The compounds steroidal and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and brain.

Aliases & Classifications for Mononeuropathy

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 25ICD10
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Related Diseases for Mononeuropathy

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Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1endocarditis30.8PRTN3
2neuropathy30.7SH3TC2, PMP22
3polyneuropathy30.5PMP22, IFNA2
4cryoglobulinemia30.4APOH, IFNA2
5mononeuritis multiplex30.2MPO, PRTN3
6churg-strauss syndrome30.2MPO, PRTN3
7hyperthyroidism30.1PRTN3, GAL
8lupus erythematosus30.1IFNA2, APOH
9peritonitis29.9PRTN3, MPO
10vasculitis29.9APOH, IFNA2, MPO, PRTN3
11ulcerative colitis29.7MPO, PRTN3, GAL
12systemic lupus erythematosus29.6APOH, PRTN3, MPO
13eosinophilia29.6IGHE, MPO, PRTN3, IFNA2
14asthma29.5MPO, PRTN3, IGHE
15charcot-marie-tooth disease10.4PMP22
16degos disease10.4APOH
17retinal vasculitis10.4APOH
18bronchiolitis10.4IGHE
19neuronitis10.4
20rhinitis10.4IGHE
21mononeuropathy of the median nerve, mild10.3
22hepatitis10.3
23purpura10.2
24mixed connective tissue disease10.2PRTN3, APOH
25sinusitis10.2PRTN3, IGHE
26diabetic neuropathy10.2
27hepatitis c10.2
28sjogren's syndrome10.2PRTN3, APOH
29hepatitis b10.1
30laryngitis10.1
31mastocytosis10.1IGHE, IFNA2
32rapidly progressive glomerulonephritis10.1PRTN3, MPO
33uveitis10.1IFNA2, GAL
34behcet's disease10.1IFNA2, APOH
35hypersensitivity vasculitis10.1MPO, PRTN3
36hemolytic anemia10.1APOH, IFNA2
37cholangitis, primary sclerosing10.1MPO, PRTN3
38wegener granulomatosis10.1MPO, PRTN3
39cork-handlers' disease10.1PRTN3, MPO
40bronchiectasis10.0MPO, IGHE
41breast cancer10.0
42b-cell lymphomas10.0
43causalgia10.0
44radiculopathy10.0
45cerebritis10.0
46complex regional pain syndrome10.0
47radial neuropathy10.0
48sarcoma10.0
49chronic pain10.0
50carcinoid syndrome10.0IFNA2, GAL

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to mononeuropathy

Symptoms for Mononeuropathy

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Drugs & Therapeutics for Mononeuropathy

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Drug clinical trials:

Search ClinicalTrials for Mononeuropathy

Search NIH Clinical Center for Mononeuropathy

Genetic Tests for Mononeuropathy

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Anatomical Context for Mononeuropathy

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MalaCards organs/tissues related to Mononeuropathy:

31
Spinal cord, Cortex, Brain, Breast, Skin, B cells, Testes, Hypothalamus, Neutrophil

Animal Models for Mononeuropathy or affiliated genes

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Publications for Mononeuropathy

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Articles related to Mononeuropathy:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Compartment syndrome with mononeuropathies after anterior cruciate ligament reconstruction. (25802956)
2015
2
Nerve biopsy findings contribute to diagnosis of multiple mononeuropathy: 78% of findings support clinical diagnosis. (25788930)
2015
3
Ultrasound diagnosis of peroneal nerve variant in a child with compressive mononeuropathy. (21292098)
2011
4
Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome. (21287183)
2011
5
Saphenous mononeuropathy after popliteal vein aneurysm repair. (20065798)
2010
6
Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists. (19285491)
2009
7
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
8
Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report. (19920803)
2009
9
Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. (18343581)
2008
10
Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy. (17383023)
2007
11
Diagnosis and management of "an apparent mechanical" femoral mononeuropathy: a case study. (18060007)
2007
12
A case of mononeuropathy multiplex with type II cryoglobulinemia, necrotizing vasculitis and low grade B cell lymphoma. (17290934)
2007
13
Mononeuropathy following subcutaneous interferon-beta injection. (16511643)
2006
14
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. (15932604)
2005
15
Italian multicentre study of peroneal mononeuropathy at the fibular head: study design and preliminary results. (15830970)
2005
16
Simvastatin-induced mononeuropathy multiplex: case report. (15273860)
2004
17
The effects of aging on thermal hyperalgesia and tactile-evoked allodynia using two models of peripheral mononeuropathy in the rat. (12614905)
2003
18
Electrodiagnostic approach to the patient with suspected mononeuropathy of the upper extremity. (12152443)
2002
19
The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model. (14622739)
2002
20
Proximal median mononeuropathy associated with an anomalous deep course through the brachialis muscle. (11032638)
2000
21
Posterior femoral cutaneous nerve mononeuropathy: a case report. (10943764)
2000
22
Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy. (10678779)
2000
23
MRI in unexplained mononeuropathy. (10788751)
2000
24
Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. (10068168)
1999
25
Mononeuropathy multiplex in hemophilia: an electrophysiologic assessment. (9693226)
1998
26
Isolated trigeminal nerve metastases from breast cancer: an unusual cause of trigeminal mononeuropathy. (9586936)
1998
27
Iatrogenic superior gluteal mononeuropathy. (9843087)
1998
28
Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. (9395132)
1997
29
A case-control and nerve biopsy study of CREST multiple mononeuropathy. (9409360)
1997
30
Mononeuropathy of a distal branch of the femoral nerve in a body building champion. (9408112)
1997
31
HIV related vasculitic mononeuropathy multiplex: a role for IVIg? (9285470)
1997
32
Complex regional pain syndrome type I (RSD) or peripheral mononeuropathy? A discussion of three cases. (8776555)
1996
33
An unusual presentation of a traumatic ulnar mononeuropathy with a Martin-Gruber anastomosis. (8965853)
1996
34
Mononeuropathy multiplex cranialis in a case of non-Hodgkin's lymphoma mistaken as paraneoplastic syndrome. (9053419)
1995
35
Femoral mononeuropathy induced by the lithotomy position: a report of 5 cases with a review of literature. (8355719)
1993
36
Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy. (1325244)
1992
37
Mononeuropathy multiplex complicating idiopathic thrombocytopenic purpura. (1653915)
1991
38
A model of peripheral mononeuropathy in the rat. (2174143)
1990
39
Immediate improvement of diabetic mononeuropathy after intravenous administration of prostaglandin E1. (2232371)
1990
40
Mononeuropathy associated with hyperthyroidism. (1963442)
1990
41
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
42
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. (2837713)
1988
43
Compressive mononeuropathy of the deep palmar branch of the ulnar nerve in cyclists. (2851643)
1988
44
Mononeuropathy multiplex (AAEE case report #11). (16758572)
1985
45
Concurrent Bell's palsy and diabetes mellitus: a diabetic mononeuropathy? (7119834)
1982
46
DFP mononeuropathy: evidence for a peripheral site of initiation. (7357425)
1980
47
Diabetic truncal mononeuropathy--a new clinical syndrome. (554781)
1978
48
Mononeuropathy. (184527)
1976
49
Hypertrophic mononeuropathy. (4360401)
1974
50
Ischemic mononeuropathy multiplex associated with diabetes mellitus. (5647941)
1968

Variations for Mononeuropathy

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Expression for genes affiliated with Mononeuropathy

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Search GEO for disease gene expression data for Mononeuropathy.

Pathways for genes affiliated with Mononeuropathy

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Pathways related to Mononeuropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0PRTN3, MPO

Compounds for genes affiliated with Mononeuropathy

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Compounds related to Mononeuropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1steroidal4310.0GAL, PMP22
2hydroxychloroquine43 1210.9APOH, IFNA2
32-methoxyethanol439.8IFNA2, IGHE
4aopp439.8MPO, APOH
5levamisole43 1210.8IGHE, IFNA2
6salbutamol43 49 28 24 1213.8GAL, IGHE
7procainamide43 1210.8MPO, APOH
8ticlopidine43 1210.7MPO, APOH
9taurine43 59 2411.7GAL, MPO
10allopurinol43 49 1211.7IFNA2, MPO
11dapsone43 2 49 1212.7IFNA2, MPO
128-isoprostane439.6APOH, MPO
13etanercept43 49 1211.6IFNA2, APOH
14budesonide43 49 1211.6IGHE, MPO
15methimazole43 2 1211.6MPO, APOH
16fluticasone propionate43 49 59 1212.6IGHE, MPO
17methanol43 2410.5MPO, APOH
18galactose439.5GAL, APOH, IFNA2
19leucovorin43 49 1211.4GAL, IFNA2
20mitoxantrone43 49 1211.4MPO, IFNA2
21cardiolipin43 1210.4APOH, PRTN3
22epinephrine43 24 1211.4GAL, IGHE, IFNA2
23octreotide43 59 28 1212.4GAL, MPO, IFNA2
245fluorouracil439.3GAL, IFNA2, MPO
25acetylcholine43 49 28 24 1213.2MPO, GAL, IGHE
26phosphatidylserine43 28 1211.2APOH, PRTN3, GAL
27indomethacin43 28 59 1212.1IGHE, IFNA2, MPO
28rituximab43 49 1211.1IFNA2, APOH, PRTN3
29azathioprine43 2 49 1212.1APOH, IFNA2, PRTN3
30arginine439.1APOH, GAL, IGHE, PMP22
31gold439.1PRTN3, APOH, IFNA2
32cytochalasin b439.0PRTN3, MPO
33formaldehyde43 2410.0MPO, PRTN3, GAL
34propylthiouracil43 2 1211.0MPO, PRTN3, APOH
35fmlp439.0PRTN3, GAL, MPO
36iron43 249.9MPO, APOH, IFNA2, GAL
37ascorbic acid43 249.9MPO, IFNA2, PMP22, IGHE
38histamine43 28 2410.8IFNA2, IGHE, MPO, GAL
39prednisolone43 28 1210.8IFNA2, MPO, APOH, IGHE
40cyclophosphamide43 49 1210.8IGHE, IFNA2, MPO, APOH
41vegf438.7IGHE, APOH, MPO, IFNA2
42infliximab43 49 1210.6PRTN3, APOH, IGHE, IFNA2
43alanine438.6IFNA2, PRTN3, IGHE, GAL
44valine438.5APOH, MPO, PRTN3, IFNA2
45superoxide43 249.5IFNA2, PRTN3, MPO, APOH
46oxygen43 249.4MPO, PRTN3, IFNA2, APOH
47nadph43 249.3GAL, PRTN3, MPO
48lipid438.3IFNA2, PRTN3, APOH, GAL
49estrogen438.2IFNA2, PRTN3, IGHE, APOH, GAL
50retinoic acid43 248.7IGHE, MPO, PRTN3, IFNA2, GAL, PMP22

GO Terms for genes affiliated with Mononeuropathy

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Cellular components related to Mononeuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.4GAL, MPO

Products for genes affiliated with Mononeuropathy

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Sources for Mononeuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet