MCID: MNN017
MIFTS: 45

Mononeuropathy malady

Neuronal diseases category

Summaries for Mononeuropathy

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Wikipedia:65 Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation,... more...

MalaCards based summary: Mononeuropathy, also known as mononeuropathies, is related to neuropathy and vasculitis. An important gene associated with Mononeuropathy is SH3TC2 (SH3 domain and tetratricopeptide repeats 2), and among its related pathways is C-MYB transcription factor network. The compounds steroidal and hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and brain.

Aliases & Classifications for Mononeuropathy

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 35MeSH, 57SNOMED-CT, 27ICD10
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Related Diseases for Mononeuropathy

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Diseases related to Mononeuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.6PMP22, SH3TC2
2vasculitis30.4APOH, MPO, PRTN3, IFNA2
3polyneuropathy30.2PMP22, IFNA2
4cryoglobulinemia30.2IFNA2, APOH
5endocarditis30.2PRTN3
6eosinophilia30.1IGHE, MPO, PRTN3, IFNA2
7mononeuritis multiplex30.1MPO, PRTN3
8churg-strauss syndrome30.1MPO, PRTN3
9hyperthyroidism29.9GAL, PRTN3
10lupus erythematosus29.9APOH, IFNA2
11peritonitis29.9MPO, PRTN3
12ulcerative colitis29.8MPO, PRTN3, GAL
13systemic lupus erythematosus29.8APOH, MPO, PRTN3
14asthma29.8IGHE, MPO, PRTN3
15neuronitis10.4
16hepatitis10.3
17mononeuropathy of the median nerve, mild10.3
18purpura10.2
19diabetic neuropathy10.2
20hepatitis c10.2
21hepatitis b10.1
22laryngitis10.1
23charcot-marie-tooth disease10.1PMP22
24degos disease10.0APOH
25retinal vasculitis10.0APOH
26breast cancer10.0
27b-cell lymphomas10.0
28causalgia10.0
29radiculopathy10.0
30cerebritis10.0
31complex regional pain syndrome10.0
32radial neuropathy10.0
33sarcoma10.0
34chronic pain10.0
35bronchiolitis10.0IGHE
36rhinitis10.0IGHE
37mixed connective tissue disease10.0PRTN3, APOH
38sinusitis10.0IGHE, PRTN3
39sjogren's syndrome10.0PRTN3, APOH
40mastocytosis10.0IFNA2, IGHE
41rapidly progressive glomerulonephritis10.0MPO, PRTN3
42behcet's disease10.0APOH, IFNA2
43uveitis10.0GAL, IFNA2
44hypersensitivity vasculitis10.0PRTN3, MPO
45hemolytic anemia10.0IFNA2, APOH
46cholangitis, primary sclerosing10.0PRTN3, MPO
47wegener granulomatosis10.0PRTN3, MPO
48cork-handlers' disease10.0PRTN3, MPO
49bronchiectasis10.0MPO, IGHE
50carcinoid syndrome10.0GAL, IFNA2

Graphical network of the top 20 diseases related to Mononeuropathy:



Diseases related to mononeuropathy

Symptoms for Mononeuropathy

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Drugs & Therapeutics for Mononeuropathy

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Drug clinical trials:

Search ClinicalTrials for Mononeuropathy

Search NIH Clinical Center for Mononeuropathy

Genetic Tests for Mononeuropathy

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Anatomical Context for Mononeuropathy

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MalaCards organs/tissues related to Mononeuropathy:

33
Spinal cord, Cortex, Brain, Breast, Skin, B cells, Testes, Hypothalamus, Neutrophil

Animal Models for Mononeuropathy or affiliated genes

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Publications for Mononeuropathy

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Articles related to Mononeuropathy:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Compartment syndrome with mononeuropathies after anterior cruciate ligament reconstruction. (25802956)
2015
2
Nerve biopsy findings contribute to diagnosis of multiple mononeuropathy: 78% of findings support clinical diagnosis. (25788930)
2015
3
Ultrasound diagnosis of peroneal nerve variant in a child with compressive mononeuropathy. (21292098)
2011
4
Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome. (21287183)
2011
5
Saphenous mononeuropathy after popliteal vein aneurysm repair. (20065798)
2010
6
Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists. (19285491)
2009
7
Multiple mononeuropathy following cocaine abuse. (21686808)
2009
8
Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report. (19920803)
2009
9
Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. (18343581)
2008
10
Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy. (17383023)
2007
11
Diagnosis and management of "an apparent mechanical" femoral mononeuropathy: a case study. (18060007)
2007
12
A case of mononeuropathy multiplex with type II cryoglobulinemia, necrotizing vasculitis and low grade B cell lymphoma. (17290934)
2007
13
Mononeuropathy following subcutaneous interferon-beta injection. (16511643)
2006
14
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. (15932604)
2005
15
Italian multicentre study of peroneal mononeuropathy at the fibular head: study design and preliminary results. (15830970)
2005
16
Simvastatin-induced mononeuropathy multiplex: case report. (15273860)
2004
17
The effects of aging on thermal hyperalgesia and tactile-evoked allodynia using two models of peripheral mononeuropathy in the rat. (12614905)
2003
18
Electrodiagnostic approach to the patient with suspected mononeuropathy of the upper extremity. (12152443)
2002
19
The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model. (14622739)
2002
20
Proximal median mononeuropathy associated with an anomalous deep course through the brachialis muscle. (11032638)
2000
21
Posterior femoral cutaneous nerve mononeuropathy: a case report. (10943764)
2000
22
Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy. (10678779)
2000
23
MRI in unexplained mononeuropathy. (10788751)
2000
24
Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. (10068168)
1999
25
Mononeuropathy multiplex in hemophilia: an electrophysiologic assessment. (9693226)
1998
26
Isolated trigeminal nerve metastases from breast cancer: an unusual cause of trigeminal mononeuropathy. (9586936)
1998
27
Iatrogenic superior gluteal mononeuropathy. (9843087)
1998
28
Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. (9395132)
1997
29
A case-control and nerve biopsy study of CREST multiple mononeuropathy. (9409360)
1997
30
Mononeuropathy of a distal branch of the femoral nerve in a body building champion. (9408112)
1997
31
HIV related vasculitic mononeuropathy multiplex: a role for IVIg? (9285470)
1997
32
Complex regional pain syndrome type I (RSD) or peripheral mononeuropathy? A discussion of three cases. (8776555)
1996
33
An unusual presentation of a traumatic ulnar mononeuropathy with a Martin-Gruber anastomosis. (8965853)
1996
34
Mononeuropathy multiplex cranialis in a case of non-Hodgkin's lymphoma mistaken as paraneoplastic syndrome. (9053419)
1995
35
Femoral mononeuropathy induced by the lithotomy position: a report of 5 cases with a review of literature. (8355719)
1993
36
Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy. (1325244)
1992
37
Mononeuropathy multiplex complicating idiopathic thrombocytopenic purpura. (1653915)
1991
38
A model of peripheral mononeuropathy in the rat. (2174143)
1990
39
Immediate improvement of diabetic mononeuropathy after intravenous administration of prostaglandin E1. (2232371)
1990
40
Mononeuropathy associated with hyperthyroidism. (1963442)
1990
41
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
42
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. (2837713)
1988
43
Compressive mononeuropathy of the deep palmar branch of the ulnar nerve in cyclists. (2851643)
1988
44
Mononeuropathy multiplex (AAEE case report #11). (16758572)
1985
45
Concurrent Bell's palsy and diabetes mellitus: a diabetic mononeuropathy? (7119834)
1982
46
DFP mononeuropathy: evidence for a peripheral site of initiation. (7357425)
1980
47
Diabetic truncal mononeuropathy--a new clinical syndrome. (554781)
1978
48
Mononeuropathy. (184527)
1976
49
Hypertrophic mononeuropathy. (4360401)
1974
50
Ischemic mononeuropathy multiplex associated with diabetes mellitus. (5647941)
1968

Variations for Mononeuropathy

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Expression for genes affiliated with Mononeuropathy

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Search GEO for disease gene expression data for Mononeuropathy.

Pathways for genes affiliated with Mononeuropathy

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Pathways related to Mononeuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0PRTN3, MPO

Compounds for genes affiliated with Mononeuropathy

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Compounds related to Mononeuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1steroidal4510.0PMP22, GAL
2hydroxychloroquine45 1310.9IFNA2, APOH
32-methoxyethanol459.8IFNA2, IGHE
4aopp459.8MPO, APOH
5levamisole45 1310.8IFNA2, IGHE
6salbutamol45 51 30 26 1313.8IGHE, GAL
7procainamide45 1310.8APOH, MPO
8ticlopidine45 1310.7MPO, APOH
9taurine45 61 2611.7MPO, GAL
10allopurinol45 51 1311.7MPO, IFNA2
11dapsone45 3 51 1312.7IFNA2, MPO
128-isoprostane459.6APOH, MPO
13etanercept45 51 1311.6IFNA2, APOH
14budesonide45 51 1311.6IGHE, MPO
15methimazole45 3 1311.6APOH, MPO
16fluticasone propionate45 51 61 1312.6IGHE, MPO
17methanol45 2610.5MPO, APOH
18galactose459.5GAL, IFNA2, APOH
19leucovorin45 51 1311.4IFNA2, GAL
20cardiolipin45 1310.4PRTN3, APOH
21mitoxantrone45 51 1311.4IFNA2, MPO
22epinephrine45 26 1311.4GAL, IFNA2, IGHE
23octreotide45 61 30 1312.4GAL, IFNA2, MPO
245fluorouracil459.3GAL, IFNA2, MPO
25acetylcholine45 51 30 26 1313.2GAL, MPO, IGHE
26phosphatidylserine45 30 1311.2GAL, PRTN3, APOH
27indomethacin45 30 61 1312.1IFNA2, MPO, IGHE
28rituximab45 51 1311.1IFNA2, PRTN3, APOH
29azathioprine45 3 51 1312.1APOH, PRTN3, IFNA2
30arginine459.1IGHE, PMP22, APOH, GAL
31gold459.1IFNA2, PRTN3, APOH
32cytochalasin b459.0MPO, PRTN3
33formaldehyde45 2610.0MPO, PRTN3, GAL
34propylthiouracil45 3 1311.0PRTN3, MPO, APOH
35fmlp459.0GAL, PRTN3, MPO
36iron45 269.9APOH, MPO, IFNA2, GAL
37ascorbic acid45 269.9IGHE, PMP22, MPO, IFNA2
38histamine45 30 2610.8IGHE, MPO, IFNA2, GAL
39prednisolone45 30 1310.8IGHE, APOH, MPO, IFNA2
40cyclophosphamide45 51 1310.8IGHE, APOH, MPO, IFNA2
41vegf458.7IGHE, APOH, MPO, IFNA2
42infliximab45 51 1310.6IFNA2, PRTN3, APOH, IGHE
43alanine458.6IGHE, PRTN3, IFNA2, GAL
44valine458.5IFNA2, PRTN3, MPO, APOH
45superoxide45 269.5APOH, MPO, PRTN3, IFNA2
46oxygen45 269.4APOH, MPO, PRTN3, IFNA2
47nadph45 269.3GAL, PRTN3, MPO
48lipid458.3GAL, IFNA2, PRTN3, APOH
49estrogen458.2IGHE, APOH, PRTN3, IFNA2, GAL
50retinoic acid45 268.7IGHE, PMP22, MPO, PRTN3, IFNA2, GAL

GO Terms for genes affiliated with Mononeuropathy

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Cellular components related to Mononeuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.4GAL, MPO

Products for genes affiliated with Mononeuropathy

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Sources for Mononeuropathy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet