MCID: MDD011
MIFTS: 53

Mood Disorder malady

Mental diseases category
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Summaries for Mood Disorder

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Most people feel sad or irritable from time to time. they may say they're in a bad mood. a mood disorder is different. it affects a person's everyday emotional state. nearly one in ten people aged 18 and older have mood disorders. these include major depressive disorder dysthymic disorder (a chronic, mild depression) bipolar disorder (also called manic depression) mood disorders can increase a person's risk for heart disease, diabetes, and other diseases. treatments include medication, psychotherapy, or a combination of both. with treatment, most people with mood disorders can lead productive lives.

MalaCards: Mood Disorder, also known as mood disorders, is related to attention deficit hyperactivity disorder and schizophrenia. An important gene associated with Mood Disorder is MT-TK (mitochondrially encoded tRNA lysine), and among its related pathways are Monoamine GPCRs and Signaling by GPCR. The drug mood stabilizer [epc] and the compounds rauwolscine and oxymetazoline have been mentioned in the context of this disorder. Affiliated tissues include heart, cortex and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:65 Mood disorder is a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM... more...

Aliases & Classifications for Mood Disorder

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Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

mood disorder 8
mood disorders 45 34 62
unspecified episodic mood disorder 62
episodic mood disorder 8


External Ids:

Disease Ontology8 DOID:3324
ICD9CM27 296.7

Related Diseases for Mood Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mood Disorder:



Diseases related to mood disorder

Symptoms for Mood Disorder

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Drugs & Therapeutics for Mood Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mood Disorder

Search NIH Clinical Center for Mood Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Mood Disorder

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Anatomical Context for Mood Disorder

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Sources:
33MalaCards
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MalaCards organs/tissues related to Mood Disorder:

33
Heart, Cortex, Brain, Pituitary, Testes, Cingulate cortex, Thyroid, Temporal lobe, Prefrontal cortex, Amygdala, Liver, Breast, Hypothalamus, Monocytes, Endothelial, Prostate, Ovary, Skin, Kidney, Cerebellum, Whole blood

Animal Models for Mood Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Mood Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.3GABRD, MAGEL2, PROK2, ADRA2C, LIN7C, AVPR1B
2MP:00053867.4GABRD, AVPR1B, GPR50, ADRA2C, HTR1B, MAGEL2

Publications for Mood Disorder

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Sources:
52PubMed
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Articles related to Mood Disorder:

(show top 50)    (show all 679)
idTitleAuthorsYear
1
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
2
Screening for Bipolar Disorder Symptoms in Depressed Primary Care Attenders: Comparison between Mood Disorder Questionnaire and Hypomania Checklist (HCL-32). (24236281)
2013
3
Fertility rates in patients with mood disorder in Sweden and Sardinia. (24089037)
2013
4
The association of migraine with menstrually related mood disorders and childhood sexual abuse. (23930948)
2013
5
Pathophysiology of mood disorders in temporal lobe epilepsy. (23429849)
2012
6
What lies behind postnatal depression: is it only a mood disorder? (22686224)
2012
7
Does current versus former smoking play a role in the relationship between anxiety and mood disorders and nicotine dependence? (22342203)
2012
8
Cross validation with the mood disorder questionnaire (MDQ) of an instrument for the detection of hypomania in Brazil: The 32 item hypomania symptom check-list, first Revision (HCI-32-R1). (22284020)
2012
9
Impact commentaries. Mood disorder as a specific complication of stroke. (22291218)
2012
10
Sensitivity and specificity of the mood disorder questionnaire and the bipolar spectrum diagnostic scale in Argentinean patients with mood disorders. (21440943)
2011
11
Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia. (21145924)
2011
12
Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. (20595426)
2010
13
Incontinence and mood disorder: is there an association? (22315640)
2010
14
Risk factors for obstructive sleep apnea syndrome screening in mood disorder patients. (19566771)
2009
15
Increased risk of suicide attempt in mood disorders and TPH1 genotype. (18977032)
2009
16
Matrix metalloproteinase-9 gene and bipolar mood disorder. (19536654)
2009
17
Validation of the Mood Disorder Questionnaire in the general population in Hong Kong. (19683618)
2009
18
Development of clinical ontology for mood disorder with combination of psychomedical information. (19697514)
2009
19
Mood disorder screening among adult emergency department patients: a multicenter study of prevalence, associations and interest in treatment. (18164934)
2008
20
Anxiety and mood disorder in young males with mitral valve prolapse. (21197339)
2008
21
Childhood abuse, suicidal behavior and the concept of post-traumatic mood disorder. (18694629)
2008
22
Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study. (16829784)
2006
23
Fatigue states after cancer treatment occur both in association with, and independent of, mood disorder: a longitudinal study. (17026776)
2006
24
Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. (16319504)
2006
25
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
26
Assessing the community prevalence of bipolar spectrum symptoms by the mood disorder questionnaire. (15741762)
2005
27
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. (15770238)
2005
28
Role of neurotrophic factors in the etiology and treatment of mood disorders. (15001809)
2004
29
Autism and familial major mood disorder: are they related? (15260372)
2004
30
Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice. (14755129)
2004
31
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
32
Predicting response to lithium in mood disorders: role of genetic polymorphisms. (12562213)
2003
33
Correlations among mood disorder, serum interleukin-2 and interleukin-6 in patients with burning mouth syndrome]. (14650995)
2003
34
Treatment-emergent tardive dyskinesia with quetiapine in mood disorders. (12920421)
2003
35
Autonomic peripheral vascular dysregulation and mood disorder. (12167529)
2002
36
Molecular genetics of mood disorders]. (12451683)
2002
37
The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder. (15014728)
2002
38
Serotonin transporter gene associated with lithium prophylaxis in mood disorders. (11913731)
2001
39
Electroconvulsive therapy in adolescents with mood disorder: patients' and parents' attitudes. (11711171)
2001
40
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
41
Mood disorder history and personality assessment in premenstrual dysphoric disorder. (11681764)
2001
42
Serotonin transporter gene not associated with psychotic symptomatology of mood disorders. (10359482)
1999
43
G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. (10461903)
1999
44
Lamotrigine as a promising approach to borderline personality: an open case series without concurrent DSM-IV major mood disorder. (10333987)
1998
45
Rhinestones and gold-dust: attention deficit, borderline personality, or mood disorder? (7646680)
1995
46
"Incomplete koro"- a forerunner for mood disorder: two case reports. (21776173)
1993
47
Nuclear magnetic resonance spectrometry in mood disorder: a preliminary report. (1912112)
1991
48
Selective response to carbamazepine in a case of organic mood disorder. (2228985)
1990
49
Efficacy of lithium in treating mood disorder occurring after brain stem injury. (7446761)
1981
50
Mood disorder as a specific complication of stroke. (591971)
1977

Variations for Mood Disorder

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Expression for genes affiliated with Mood Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mood Disorder

Search GEO for disease gene expression data for Mood Disorder.

Pathways for genes affiliated with Mood Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG
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Compounds for genes affiliated with Mood Disorder

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Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Mood Disorder according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1rauwolscine2910.1HTR1B, ADRA2C
2oxymetazoline45 29 1112.1HTR1B, ADRA2C
3roxindole29 4511.1HTR1B, ADRA2C
4terguride45 2911.1HTR1B, ADRA2C
5ropinirole45 1111.1ADRA2C, HTR1B
6lisuride45 29 1112.1HTR1B, ADRA2C
7pergolide45 29 1112.1HTR1B, ADRA2C
8pramipexole45 29 51 1113.1ADRA2C, HTR1B
9asenapine29 1111.0HTR1B, ADRA2C
10cabergoline45 29 1112.0ADRA2C, HTR1B
11aripiprazole29 45 51 24 1114.0HTR1B, ADRA2C
12ziprasidone29 51 45 1113.0HTR1B, ADRA2C
13yohimbine45 3 29 1112.9HTR1B, ADRA2C
14apomorphine29 45 1111.9ADRA2C, HTR1B
15quetiapine45 51 29 24 1113.8HTR1B, ADRA2C
16olanzapine45 51 29 24 1113.8HTR1B, ADRA2C
17bromocriptine45 29 1111.7HTR1B, ADRA2C
18risperidone45 51 29 61 24 1114.5HTR1B, ADRA2C

GO Terms for genes affiliated with Mood Disorder

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16Gene Ontology
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Cellular components related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.3GABRD, HTR1B, ADRA2C, GPR50, AVPR1B

Biological processes related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:0071868.1TAAR6, PROK2, ADRA2C, GPR50, AVPR1B

Products for genes affiliated with Mood Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mood Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet