MCID: MDD011
MIFTS: 56

Mood Disorder malady

Neuronal category

Summaries for Mood Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Most people feel sad or irritable from time to time. they may say they're in a bad mood. a mood disorder is different. it affects a person's everyday emotional state. nearly one in ten people aged 18 and older have mood disorders. these include major depressive disorder dysthymic disorder (a chronic, mild depression) bipolar disorder (also called manic depression) mood disorders can increase a person's risk for heart disease, diabetes, and other diseases. treatments include medication, psychotherapy, or a combination of both. with treatment, most people with mood disorders can lead productive lives.

MalaCards: Mood Disorder, also known as mood disorders, is related to bipolar disorder and anxiety disorder. An important gene associated with Mood Disorder is BDNF (brain-derived neurotrophic factor), and among its related pathways are Circadian entrainment and Signaling by GPCR. The drug mood stabilizer [epc] and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:64 Mood disorder is a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM... more...

Aliases & Classifications for Mood Disorder

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

mood disorder 8
mood disorders 45 34 61
unspecified episodic mood disorder 61
episodic mood disorder 8


External Ids:

Disease Ontology8 DOID:3324
ICD9CM27 296.7

Related Diseases for Mood Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mood Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.4SLC6A4, NOS1
2anxiety disorder30.9HTR1A, TPH1, SLC6A4, BDNF, CRH, MAOA
3obsessive-compulsive disorder30.6TPH1, SLC6A4, BDNF, HTR1B, HTR1A, DRD4
4schizoaffective disorder30.6BDNF, DRD4, DAOA, SLC6A4, NOS1
5melancholia30.5CRH, MAOA
6borderline personality disorder30.5SLC6A4, TPH1, MAOA, HTR1B
7substance abuse30.4SLC6A4, CRH, DRD4
8attention deficit hyperactivity disorder30.3DRD4, ADRA2A, MAOA, SLC6A4, HTR1B, BDNF
9panic disorder30.3HTR1A, SLC6A4, CRH
10pathological gambling30.3DRD4
11seasonal affective disorder30.2HTR1A, DRD4, CRH, SLC6A4, TPH1
12alcohol dependence30.2HTR1B, DRD4, CRH, MAOA, SLC6A4
13substance dependence30.2TPH1, SLC6A4, DRD4
14social phobia30.2HTR1A, MAOA, SLC6A4
15fibromyalgia30.2CRH, SLC6A4
16temporal lobe epilepsy30.2BDNF, HTR1A, NTRK2
17generalized anxiety disorder30.2SLC6A4, HTR1A
18dysthymic disorder30.2MAOA, HCRT
19alcohol abuse30.2SLC6A4
20nicotine dependence29.9SLC6A4, NTRK2, DRD4
21narcolepsy29.9HCRT, CLOCK
22developmental disabilities29.9BDNF, HTR1A
23bipolar i disorder10.7
24major depressive disorder10.5
25sleep disorder10.4
26insomnia10.3
27borna disease10.3
28adjustment disorder10.2
29tardive dyskinesia10.2
30neurotic disorder10.1
31alexithymia10.1
32organic mood syndrome10.1
33ataxia10.1
34brain injury10.1
35hypersomnia10.1
36schizophrenia10.0GNB3, HTR1B, HTR1A, HTR6, DRD4, WFS1
37alzheimer's disease10.0SLC6A4, NOS1, TPH1, HCRT, HTR6, MAOA
38obesity10.0CRH, NTRK2, MAOA, HCRT, CLOCK, NOS1
39parkinson's disease10.0BDNF, NTRK2, HTR1B, HCRT, HTR1A, DRD4
40psychotic disorder10.0BDNF, GNB3, HTR1A, DRD4, MAOA, DAOA
41dopa-responsive cervical dystonia10.0TPH1, BDNF, GNB3, HTR1A, CRH, MAOA
42anorexia nervosa10.0DRD4, TPH1, BDNF, HTR1A, CRH, MAOA
43migraine10.0TPH1, SLC6A4, MAOA, DRD4, HCRT, HTR1A
44epilepsy syndrome10.0MAOA, NOS1, TPH1, NTRK2, GABRA1, HTR1A
45eating disorder10.0CRH, HCRT, NTRK2, HTR1A, BDNF, SLC6A4
46dementia10.0HTR1A, NTRK2, BDNF, MAOA, NOS1, HCRT
47personality disorder10.0MAOA, DRD4, TPH1, SLC6A4, HTR1B
48gilles de la tourette syndrome10.0ADRA2A, MAOA, SLC6A4, HTR1A, DRD4
49ischemia10.0BDNF, HCRT, HTR1A, NOS1, NTRK2
50bulimia nervosa10.0BDNF, HTR1B, MAOA, SLC6A4

Graphical network of the top 20 diseases related to Mood Disorder:



Diseases related to mood disorder

Clinical Features for Mood Disorder

Drugs & Therapeutics for Mood Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mood Disorder

Drug clinical trials:

Search ClinicalTrials for Mood Disorder

Search NIH Clinical Center for Mood Disorder

Search CenterWatch for Mood Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Mood Disorder

Anatomical Context for Mood Disorder

Animal Models for Mood Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Mood Disorder

Sources:
51PubMed
See all sources

Articles related to Mood Disorder:

(show top 50)    (show all 813)
idTitleAuthorsYear
1
Relationship of coping style to mood and anxiety disorders in dementia carers. (24270483)
2014
2
Screening for Bipolar Disorder Symptoms in Depressed Primary Care Attenders: Comparison between Mood Disorder Questionnaire and Hypomania Checklist (HCL-32). (24236281)
2013
3
The dynamics of mood and coping in bipolar disorder: longitudinal investigations of the inter-relationship between affect, self-esteem and response styles. (23638104)
2013
4
Is it useful to use the Korean version of the mood disorder questionnaire for assessing bipolar spectrum disorder among Korean college students? (23857742)
2013
5
Irritable mood in adult major depressive disorder: results from the world mental health surveys. (23364997)
2013
6
Cross validation with the mood disorder questionnaire (MDQ) of an instrument for the detection of hypomania in Brazil: The 32 item hypomania symptom check-list, first Revision (HCI-32-R1). (22284020)
2012
7
Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles. (21798721)
2012
8
Mood disorder with psychotic symptoms and overlooked skin lesions: the strange case of Mrs. O. (23160056)
2012
9
Do parents know best? Parent-reported vs. child-reported depression symptoms as predictors of future child mood disorder in a high-risk sample. (22609197)
2012
10
Sensitivity and specificity of the Mood Disorder Questionnaire as a screening tool for bipolar disorder during pregnancy and the postpartum period. (23146292)
2012
11
Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders. (21803059)
2012
12
Efficacy of memoral herbal on prevention of electroconvulsive therapy-induced memory impairment in mood disorder patients (isfahan - iran 2011). (22891152)
2012
13
Association between major mood disorders and the hypocretin receptor 1 gene. (21071097)
2011
14
An overview of Indian research in bipolar mood disorder. (21836675)
2010
15
Emotion perception in Alzheimer's disease and mood disorder in old age. (20230126)
2010
16
A model of suicidal behavior in war veterans with posttraumatic mood disorder. (19327892)
2009
17
5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients. (19361869)
2009
18
Parents of children with periodic limb movement disorder versus sleep-disordered breathing report greater daytime mood and behavior difficulties in their child: the importance of using ICSD-2nd Edition criteria to define a PLMD study group. (19568964)
2009
19
Adaptation and validation of the Spanish version of the Mood Disorder Questionnaire for the detection of bipolar disorder. (18402628)
2008
20
Case report of treatment of severe mood disorder in an inpatient setting: when less is more. (18774436)
2008
21
No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population. (18085546)
2008
22
Mood disorder and epilepsy: a neurobiologic perspective of their relationship. (18472483)
2008
23
Association study of serotonin system genes in childhood-onset mood disorder. (18349694)
2008
24
Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder. (18297417)
2008
25
Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (17909131)
2007
26
Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders. (17100580)
2006
27
Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. (16222333)
2006
28
Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders. (16165159)
2006
29
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
30
The incidence of delirium in older people with a mood disorder is similar with lithium and valproate. (16246871)
2005
31
The interpretation of negative social events in social phobia with versus without comorbid mood disorder. (15686856)
2005
32
Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders. (15473915)
2005
33
Deficiency of theory of mind in patients with remitted mood disorder. (15555691)
2004
34
The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. (15458611)
2004
35
Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. (15564899)
2004
36
Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. (14527651)
2003
37
The Mood Disorder Questionnaire in Primary Care: (Not) Ready for Prime Time? (15014727)
2002
38
Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. (12399952)
2002
39
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. (11430844)
2001
40
Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. (11578639)
2001
41
Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders. (11353438)
2001
42
Neuroplasticity and cellular resilience in mood disorders. (11126389)
2000
43
Lamotrigine as a promising approach to borderline personality: an open case series without concurrent DSM-IV major mood disorder. (10333987)
1998
44
Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. (9577842)
1998
45
Self-esteem in remitted patients with mood disorders is not associated with the dopamine receptor D4 and the serotonin transporter genes. (9754692)
1998
46
Successful treatment of interferon-alpha-induced mood disorder with nortriptyline. (7652148)
1995
47
Seasonal concordance of recurrence in mood disorder patients. (19698335)
1995
48
Single episode of major depressive disorder. First episode of recurrent mood disorder or distinct subtype of late-onset depression? (8323988)
1993
49
Medication and family therapy for schizophrenia and mood disorder. (1480723)
1992
50
Kleptomania, mood disorder and lithium. (1309165)
1992

Genetic Variations for Mood Disorder

Expression for genes affiliated with Mood Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mood Disorder

Search GEO for disease gene expression data for Mood Disorder.

Pathways for genes affiliated with Mood Disorder

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Mood Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1HTR1B, GABRA1, GNB3, HTR1A, HTR6, NOS1
2
Hide members
11.1ADRA2A, GNB3, HCRT, NTRK2, CRH, GALR1
3
Hide members
11.1HTR6, HTR1A, HTR1B, ADRA2A, GNB3, DRD4
411.0HTR1A, GNB3, MAOA, GABRA1, NTRK2, BDNF
5
Hide members
10.9HTR1B, ADRA2A, SLC6A4, MAOA, DRD4, HTR6
610.8WFS1, NTRK2, GNB3, NOS1, TPH1, HTR1A
7
Hide members
10.8NTRK2, BDNF, GNB3, HTR1B, HTR1A, HTR6
810.8GNB3, CRH, NTRK2, MAOA, BDNF
9
Hide members
10.7BDNF, NTRK2, DRD4, GNB3
10
Hide members
10.7BDNF, GNB3, CRH, NOS1
1110.7HTR1A, GNB3, WFS1

Compounds for genes affiliated with Mood Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Mood Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2415.0NTRK2, DRD4, HTR6, HTR1A, HTR1B, BDNF
2norepinephrine45 11 2413.7TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
3gaba4511.6TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
4glutamate4511.6NOS1, ADRA2A, BDNF, DRD4, MAOA, CRH
55-hydroxytryptamine4511.5MAOA, CRH, DRD4, HTR6, HTR1A, HTR1B
6fluoxetine50 45 29 1114.5MAOA, TPH1, NOS1, SLC6A4, CRH, HTR1A
7clozapine45 29 50 1114.5HTR1A, BDNF, GNB3, HTR1B, ADRA2A, NOS1
8cocaine45 1112.4SIGMAR1, NOS1, SLC6A4, HCRT, CRH, DRD4
9nmda45 2912.4HTR6, NOS1, HTR1A, DAOA, HCRT, MAOA
10nicotine45 50 29 1114.4NTRK2, TPH1, CRH, DRD4, NOS1, MAOA
11maoa4511.4DRD4, HTR1A, HTR1B, BDNF, MAOA, SLC6A4
12paroxetine45 50 29 1114.3HTR1B, BDNF, TPH1, SLC6A4, MAOA, DRD4
13methamphetamine45 50 1113.3BDNF, DRD4, MAOA, SLC6A4, NOS1, ADRA2A
14epinephrine45 11 2413.3GNB3, BDNF, SLC6A4, HCRT, MAOA, CRH
15risperidone29 45 50 60 11 2416.3HTR1A, BDNF, HTR6, DRD4, SLC6A4, ADRA2A
16olanzapine50 45 29 11 2415.3BDNF, HTR1A, ADRA2A, DRD4, HTR6, GNB3
17catecholamine4511.3HCRT, DRD4, BDNF, ADRA2A, CRH, MAOA
18testosterone45 60 11 2414.3ADRA2A, NOS1, SLC6A4, NTRK2, HCRT, MAOA
19fluvoxamine45 50 1113.3TPH1, SLC6A4, CLOCK, HTR1A, BDNF, MAOA
20amitriptyline45 50 29 1114.3ADRA2A, MAOA, HTR6, NTRK2, SLC6A4, HTR1A
21quetiapine45 50 29 11 2415.3DRD4, HTR6, ADRA2A, HTR1A, BDNF, HTR1B
22mhpg4511.2SLC6A4, DRD4, MAOA, CRH, BDNF
23lithium45 50 11 2414.2BDNF, GNB3, TPH1, NTRK2, SLC6A4, CLOCK
24citalopram50 45 11 2414.2TPH1, MAOA, HTR1A, BDNF, SLC6A4
25methylphenidate45 50 1113.2DRD4, ADRA2A, SLC6A4, HCRT, MAOA
26lisuride29 45 1113.2HTR1B, HTR6, DRD4, ADRA2A, HTR1A
27mianserin29 45 1113.2ADRA2A, SLC6A4, HTR1A, HTR6, MAOA
28levodopa45 1112.2TPH1, MAOA, DRD4, HTR1A, BDNF, HTR1B
29homovanillic acid45 2412.2MAOA, BDNF, CRH, SLC6A4, TPH1
30fenfluramine29 45 1113.2SLC6A4, TPH1, HTR1A, HTR1B, CRH
31corticosterone45 60 2413.1HTR1A, NOS1, SLC6A4, HCRT, CRH, BDNF
32pramipexole45 50 29 1114.1ADRA2A, DRD4, HTR1B, HTR1A, BDNF
33haloperidol45 29 2 50 1115.1BDNF, SIGMAR1, HCRT, DRD4, HTR1A, SLC6A4
34clomipramine45 50 1113.1CRH, HCRT, SLC6A4, MAOA, HTR1A
35asenapine29 1112.1ADRA2A, HTR1B, DRD4, HTR1A, HTR6
36sumatriptan45 29 60 50 11 2416.1MAOA, HTR1A, HTR1B, GNB3, HTR6
37aripiprazole29 50 45 11 2415.1DRD4, HTR1A, HTR1B, ADRA2A, HTR6
38ziprasidone50 29 45 1114.1HTR1B, HTR1A, HTR6, ADRA2A, DRD4
39desipramine45 50 1113.0CRH, HTR1A, BDNF, MAOA, SLC6A4
40bromocriptine29 45 1113.0ADRA2A, HTR1B, DRD4, HTR6, HTR1A
41amoxapine45 29 1113.0ADRA2A, HTR6, GABRA1, SLC6A4
42chlorpromazine45 29 50 1114.0BDNF, HTR1A, HTR6, DRD4, ADRA2A
43mdma4511.0TPH1, SLC6A4, MAOA, HTR1A
44terguride29 4511.9HTR1B, ADRA2A, DRD4, HTR1A
45amphetamine45 1111.9TPH1, DRD4, MAOA, SLC6A4, HCRT
46antidepressants5010.8TPH1, GNB3, BDNF, HTR1A
47imipramine45 50 29 11 2414.8SLC6A4, MAOA, HTR1A, BDNF, NOS1
485-hydroxytryptophan4510.7TPH1, CRH, HTR1A, SLC6A4
49methysergide45 29 1112.6MAOA, HTR1A, HTR1B, HTR6
50choline45 11 2412.6ADRA2A, MAOA, SLC6A4, NOS1, TPH1, BDNF

GO Terms for genes affiliated with Mood Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADRA2A, HTR1B, HTR1A, HTR6, DRD4, GABRA1
2dendritic spineGO:04319710.7NOS1, NTRK2, DRD4

Biological processes related to Mood Disorder according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2HTR6, GNB3, HTR1B, GABRA1, CRH, MAOA
2negative regulation of cAMP biosynthetic processGO:03081811.0ADRA2A, HTR1B, DRD4
3regulation of neurotransmitter secretionGO:04692811.0HCRT, DRD4, NTRK2
4vasoconstrictionGO:04231011.0SLC6A4, HTR1A, HTR1B
5behavioral fear responseGO:00166211.0HTR1A, BDNF, DRD4
6negative regulation of adenylate cyclase activityGO:00719411.0DRD4, ADRA2A, GALR1
7feeding behaviorGO:00763111.0CRH, BDNF, NTRK2
8regulation of serotonin secretionGO:01406210.9CRH, HTR1A
9circadian rhythmGO:00762310.9CLOCK, SLC6A4, TPH1
10adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.9HTR1A, HTR1B
11fear responseGO:04259610.9DRD4, ADRA2A
12response to immobilization stressGO:03590210.9TPH1, CRH
13negative regulation of epinephrine secretionGO:03281110.8CRH, ADRA2A
14mechanoreceptor differentiationGO:04249010.8NTRK2, BDNF
15negative regulation of norepinephrine secretionGO:01070010.8CRH, ADRA2A
16regulation of dopamine metabolic processGO:04205310.8HTR1A, DRD4
17regulation of behaviorGO:05079510.7HTR1B, HTR1A
18negative regulation of potassium ion transportGO:04326710.7NOS1, HCRT
19synaptic transmission, dopaminergicGO:00196310.6CRH, DRD4
20neurotransmitter biosynthetic processGO:04213610.6NOS1, MAOA
21negative regulation of neuron apoptotic processGO:04352410.6BDNF, WFS1, NTRK2
22bone remodelingGO:04684910.3TPH1, HTR1B

Molecular functions related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00499310.7HTR6, HTR1A, HTR1B
2drug bindingGO:00814410.4SIGMAR1, GABRA1, DRD4, HTR1B

Products for genes affiliated with Mood Disorder

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  • Lysates
  • Antibodies

Sources for Mood Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet