MCID: MDD011
MIFTS: 64

Mood Disorder malady

Neuronal diseases category

Summaries for Mood Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Most people feel sad or irritable from time to time. they may say they're in a bad mood. a mood disorder is different. it affects a person's everyday emotional state. nearly one in ten people aged 18 and older have mood disorders. these include major depressive disorder dysthymic disorder (a chronic, mild depression) bipolar disorder (also called manic depression) mood disorders can increase a person's risk for heart disease, diabetes, and other diseases. treatments include medication, psychotherapy, or a combination of both. with treatment, most people with mood disorders can lead productive lives.

MalaCards: Mood Disorder, also known as mood disorders, is related to bipolar disorder and schizophrenia. An important gene associated with Mood Disorder is BDNF (brain-derived neurotrophic factor), and among its related pathways are Circadian entrainment and Signaling by GPCR. The drug mood stabilizer [epc] and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, cortex and brain, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:63 Mood disorder is a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM... more...

Aliases & Classifications for Mood Disorder

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mood disorder 8
mood disorders 44 33 60
unspecified episodic mood disorder 60
episodic mood disorder 8


External Ids:

Disease Ontology8 DOID:3324
ICD9CM27 296.7

Related Diseases for Mood Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mood Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.4NOS1, SLC6A4
2schizophrenia31.2NTRK2, MAOA, HCRT, CLOCK, DAOA, SLC6A4
3anxiety disorder30.9BDNF, HTR1A, CRH, MAOA, SLC6A4, TPH1
4personality disorder30.9HTR1B, DRD4, MAOA, SLC6A4, TPH1
5psychotic disorder30.8NOS1, TPH1, SLC6A4, DAOA, MAOA, BDNF
6schizoaffective disorder30.6NOS1, BDNF, DRD4, DAOA, SLC6A4
7obsessive-compulsive disorder30.5BDNF, HTR1B, HTR1A, DRD4, MAOA, SLC6A4
8melancholia30.5MAOA, CRH
9borderline personality disorder30.4HTR1B, MAOA, SLC6A4, TPH1
10multiple sclerosis30.4HCRT, NTRK2, BDNF
11substance abuse30.3SLC6A4, CRH, DRD4
12migraine30.2HTR1B, HTR1A, DRD4, MAOA, HCRT, SLC6A4
13attention deficit hyperactivity disorder30.2TPH1, ADRA2A, SLC6A4, MAOA, DRD4, HTR1B
14substance dependence30.2TPH1, SLC6A4, DRD4
15panic disorder30.2HTR1A, CRH, SLC6A4
16pathological gambling30.2DRD4
17eating disorder30.1BDNF, HTR1A, CRH, NTRK2, HCRT, SLC6A4
18seasonal affective disorder30.1HTR1A, DRD4, CRH, SLC6A4, TPH1
19alcohol dependence30.1HTR1B, DRD4, CRH, MAOA, SLC6A4
20social phobia30.1HTR1A, MAOA, SLC6A4
21temporal lobe epilepsy30.1BDNF, HTR1A, NTRK2
22dysthymic disorder30.1MAOA, HCRT
23generalized anxiety disorder30.1HTR1A, SLC6A4
24developmental disabilities30.1BDNF, HTR1A
25alcohol abuse30.1SLC6A4
26alzheimer's disease29.9GALR1, DRD4, HTR6, HTR1A, BDNF, CRH
27dementia29.9BDNF, HTR1A, NTRK2, MAOA, HCRT, NOS1
28nicotine dependence29.9DRD4, NTRK2, SLC6A4
29endogenous depression29.9CRH, MAOA
30narcolepsy29.9HCRT, CLOCK
31cocaine dependence29.9SLC6A4
32fragile x syndrome29.9SLC6A4
33major depressive disorder10.6
34bipolar i disorder10.4
35sexual disorder10.3
36sleep disorder10.3
37borna disease10.2
38neuronitis10.2
39delusional disorder10.2
40physical disorder10.2
41thyroiditis10.2
42adjustment disorder10.2
43alexithymia10.1
44breast cancer10.1
45dissociative disorder10.1
46intellectual disability10.1
47mitochondrial disorders10.1
48obesity10.0GNB3, HTR1A, DRD4, GALR1, CRH, NTRK2
49parkinson's disease10.0BDNF, HTR1B, HTR1A, TPH1, NOS1, SLC6A4
50anorexia nervosa10.0TPH1, SLC6A4, HCRT, BDNF, HTR1A, DRD4

Graphical network of the top 20 diseases related to Mood Disorder:



Diseases related to mood disorder

Clinical Features for Mood Disorder

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Drugs & Therapeutics for Mood Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mood Disorder

Drug clinical trials:

Search ClinicalTrials for Mood Disorder

Search NIH Clinical Center for Mood Disorder

Search CenterWatch for Mood Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mood Disorder

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Anatomical Context for Mood Disorder

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32MalaCards
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MalaCards organs/tissues related to Mood Disorder:

32
Heart, Cortex, Brain, Pituitary, Testes, Amygdala, Temporal lobe, Prefrontal cortex, Thyroid, Cingulate cortex, Breast, Liver, Hypothalamus, Monocytes, Endothelial, Prostate, Ovary, Skin, Kidney, Cerebellum, Whole blood, Eye

Animal Models for Mood Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mood Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.6TPH1, BDNF, HTR1B, HTR1A, HTR6, DRD4
2MP:000537611.5CRH, GABRA1, DRD4, HTR6, HTR1A, BDNF
3MP:000363111.3BDNF, GNB3, HTR1A, DRD4, GABRA1, CRH
4MP:000537811.1CRH, GABRA1, HTR6, HTR1B, BDNF, WFS1
5MP:000287310.9GABRA1, CRH, NTRK2, SLC6A4, NOS1, ADRA2A
6MP:000538510.7HTR1B, HTR1A, MAOA, HCRT, CLOCK, SLC6A4

Publications for Mood Disorder

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50PubMed
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Articles related to Mood Disorder:

(show top 50)    (show all 813)
idTitleAuthorsYear
1
The association of migraine with menstrually related mood disorders and childhood sexual abuse. (23930948)
2013
2
Detecting mood disorder in resource-limited primary care settings: comparison of a self-administered screening tool to general practitioner assessment. (24080916)
2013
3
Using a hybrid model to investigate the comorbidity and symptom overlap between social phobia and the other anxiety disorders and unipolar mood disorders. (23809463)
2013
4
Toward a systems biology of mood disorder. (23245950)
2013
5
Coping patterns and their relation to daily activity, worries, depressed mood, and pain intensity in acute whiplash-associated disorders. (22382932)
2013
6
Attention orienting and inhibitory control across the different mood states in bipolar disorder: an emotional antisaccade task. (24161800)
2013
7
The Mood Disorder Questionnaire (MDQ) for detecting (hypo)manic episodes: its validity and impact of recall bias. (23790555)
2013
8
Empathy and social problem solving in alcohol dependence, mood disorders and selected personality disorders. (23396051)
2013
9
Using the mood disorder questionnaire and bipolar spectrum diagnostic scale to detect bipolar disorder and borderline personality disorder among eating disorder patients. (23443034)
2013
10
Prevalence and functional consequences of severe insomnia symptoms in mood and anxiety disorders: results from a nationally representative sample. (23024435)
2012
11
Screening for bipolar disorders in patients with alcohol or substance use disorders: performance of the mood disorder questionnaire. (22341144)
2012
12
Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt. (22460132)
2012
13
Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. (22483286)
2012
14
The prevalence and course of pathological gambling in the mood disorders. (20502951)
2011
15
A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder. (21497910)
2011
16
Long-term mood disorder antedating the diagnosis of Wilson's disease. (21537730)
2011
17
Women and depression. It is not clear what underlies the gender gap in this mood disorder. (21674884)
2011
18
Test performance of the Cantonese Chinese Mood Disorder Questionnaire for detecting bipolar spectrum disorder in the community of Hong Kong. (22201215)
2011
19
Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. (22013141)
2011
20
Psychiatric diagnoses in patients who screen positive on the Mood Disorder Questionnaire: Implications for using the scale as a case-finding instrument for bipolar disorder. (20656360)
2011
21
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder. (21782428)
2011
22
Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. (20010318)
2010
23
The utility of Mood Disorder Questionnaire for the detection of bipolar diathesis in treatment-resistant depression. (20060173)
2010
24
Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind trial. (20122373)
2010
25
Lord Clive did not suffer a mood disorder. (20136532)
2010
26
Matrix metalloproteinase-9 gene and bipolar mood disorder. (19536654)
2009
27
Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study. (16690084)
2007
28
Movement and mood disorder in two brothers with Gaucher disease. (17850633)
2007
29
Adjunctive treatment for mood stabilization of patients with bipolar I disorder treated with lamotrigine. (16946696)
2006
30
Factors associated with positive screens on the mood disorder questionnaire in primary care. (17235382)
2006
31
Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders. (16863269)
2006
32
Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. (15845098)
2005
33
Glutamate modulators as novel interventions for mood disorders. (16224615)
2005
34
48,XXYY syndrome, mood disorder, and aggression. (15994727)
2005
35
BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population. (15118355)
2004
36
Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder. (12000206)
2002
37
Olanzapine therapy in treatment-resistant psychotic mood disorders: a long-term follow-up study. (11488360)
2001
38
Glutamate-hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders. (15573019)
2001
39
Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness: evidence in support of the catecholamine hypothesis of mood disorders. (10920468)
2000
40
Electroencephalographic findings in patients with DSM-IV mood disorder, schizophrenia, and other psychotic disorders. (9442346)
1998
41
Anxiety and mood disorders associated with gonadotropin-releasing hormone agonist therapy. (9230649)
1997
42
The sensitization hypothesis and importance of psychosensory features in mood disorder: a review. (9447492)
1997
43
Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy. (8971108)
1996
44
Delusional disorder and mood disorder: can they coexist? (8321893)
1993
45
Psychosocial preventive intervention for families with parental mood disorder: strategies for the clinician. (8408671)
1993
46
Organic mood disorder associated with the HAIR-AN syndrome. (1627962)
1992
47
Mood disorder in a group of self-cutting adolescents. (1585801)
1992
48
Mood disorder, 'pre-ictal' psychosis and temporal lobe damage. (2245281)
1990
49
Altered zinc metabolism in mood disorder patients. (2790104)
1989
50
Nitrous oxide mood disorder. (3244066)
1988

Genetic Variations for Mood Disorder

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Expression for genes affiliated with Mood Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mood Disorder

Search GEO for disease gene expression data for Mood Disorder.

Pathways for genes affiliated with Mood Disorder

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Mood Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GABRA1
2
Hide members
11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GALR1
3
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11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GALR1
411.0BDNF, GNB3, HTR1A, GABRA1, NTRK2, MAOA
5
Hide members
10.9ADRA2A, HTR1B, HTR1A, HTR6, DRD4, MAOA
610.8GNB3, HTR1A, WFS1, NTRK2, NOS1, TPH1
7
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10.8BDNF, GNB3, HTR1B, HTR1A, HTR6, NTRK2
810.8BDNF, GNB3, CRH, NTRK2, MAOA
9
Hide members
10.7NTRK2, DRD4, GNB3, BDNF
10
Hide members
10.7BDNF, GNB3, CRH, NOS1
1110.7WFS1, HTR1A, GNB3

Compounds for genes affiliated with Mood Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Mood Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2415.0NTRK2, DRD4, HTR6, HTR1A, HTR1B, BDNF
2norepinephrine44 11 2413.7TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
3gaba4411.6TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
4glutamate4411.6NOS1, ADRA2A, BDNF, DRD4, MAOA, CRH
55-hydroxytryptamine4411.5MAOA, CRH, DRD4, HTR6, HTR1A, HTR1B
6fluoxetine49 44 28 1114.5MAOA, TPH1, NOS1, SLC6A4, CRH, HTR1A
7clozapine44 28 49 1114.5HTR1A, BDNF, GNB3, HTR1B, ADRA2A, NOS1
8cocaine44 1112.4SIGMAR1, NOS1, SLC6A4, HCRT, CRH, DRD4
9nmda44 2812.4HTR6, NOS1, HTR1A, DAOA, HCRT, MAOA
10nicotine44 49 28 1114.4NTRK2, TPH1, CRH, DRD4, NOS1, MAOA
11maoa4411.4DRD4, HTR1A, HTR1B, BDNF, MAOA, SLC6A4
12paroxetine44 49 28 1114.3HTR1B, BDNF, TPH1, SLC6A4, MAOA, DRD4
13methamphetamine44 49 1113.3BDNF, DRD4, MAOA, SLC6A4, NOS1, ADRA2A
14epinephrine44 11 2413.3GNB3, BDNF, SLC6A4, HCRT, MAOA, CRH
15risperidone28 44 49 59 11 2416.3HTR1A, BDNF, HTR6, DRD4, SLC6A4, ADRA2A
16olanzapine49 44 28 11 2415.3BDNF, HTR1A, ADRA2A, DRD4, HTR6, GNB3
17catecholamine4411.3HCRT, DRD4, BDNF, ADRA2A, CRH, MAOA
18testosterone44 59 11 2414.3ADRA2A, NOS1, SLC6A4, NTRK2, HCRT, MAOA
19fluvoxamine44 49 1113.3TPH1, SLC6A4, CLOCK, HTR1A, BDNF, MAOA
20amitriptyline44 49 28 1114.3ADRA2A, MAOA, HTR6, NTRK2, SLC6A4, HTR1A
21quetiapine44 49 28 11 2415.3DRD4, HTR6, ADRA2A, HTR1A, BDNF, HTR1B
22mhpg4411.2SLC6A4, DRD4, MAOA, CRH, BDNF
23lithium44 49 11 2414.2BDNF, GNB3, TPH1, NTRK2, SLC6A4, CLOCK
24citalopram49 44 11 2414.2TPH1, MAOA, HTR1A, BDNF, SLC6A4
25methylphenidate44 49 1113.2DRD4, ADRA2A, SLC6A4, HCRT, MAOA
26lisuride28 44 1113.2HTR1B, HTR6, DRD4, ADRA2A, HTR1A
27mianserin28 44 1113.2ADRA2A, SLC6A4, HTR1A, HTR6, MAOA
28levodopa44 1112.2TPH1, MAOA, DRD4, HTR1A, BDNF, HTR1B
29homovanillic acid44 2412.2MAOA, BDNF, CRH, SLC6A4, TPH1
30fenfluramine28 44 1113.2SLC6A4, TPH1, HTR1A, HTR1B, CRH
31corticosterone44 59 2413.1HTR1A, NOS1, SLC6A4, HCRT, CRH, BDNF
32pramipexole44 49 28 1114.1ADRA2A, DRD4, HTR1B, HTR1A, BDNF
33haloperidol44 28 2 49 1115.1BDNF, SIGMAR1, HCRT, DRD4, HTR1A, SLC6A4
34clomipramine44 49 1113.1CRH, HCRT, SLC6A4, MAOA, HTR1A
35asenapine28 1112.1ADRA2A, HTR1B, DRD4, HTR1A, HTR6
36sumatriptan44 28 59 49 11 2416.1MAOA, HTR1A, HTR1B, GNB3, HTR6
37aripiprazole28 49 44 11 2415.1DRD4, HTR1A, HTR1B, ADRA2A, HTR6
38ziprasidone49 28 44 1114.1HTR1B, HTR1A, HTR6, ADRA2A, DRD4
39desipramine44 49 1113.0CRH, HTR1A, BDNF, MAOA, SLC6A4
40bromocriptine28 44 1113.0ADRA2A, HTR1B, DRD4, HTR6, HTR1A
41amoxapine44 28 1113.0ADRA2A, HTR6, GABRA1, SLC6A4
42chlorpromazine44 28 49 1114.0BDNF, HTR1A, HTR6, DRD4, ADRA2A
43mdma4411.0TPH1, SLC6A4, MAOA, HTR1A
44terguride28 4411.9HTR1B, ADRA2A, DRD4, HTR1A
45amphetamine44 1111.9TPH1, DRD4, MAOA, SLC6A4, HCRT
46antidepressants4910.8TPH1, GNB3, BDNF, HTR1A
47imipramine44 49 28 11 2414.8SLC6A4, MAOA, HTR1A, BDNF, NOS1
485-hydroxytryptophan4410.7TPH1, CRH, HTR1A, SLC6A4
49methysergide44 28 1112.6MAOA, HTR1A, HTR1B, HTR6
50choline44 11 2412.6ADRA2A, MAOA, SLC6A4, NOS1, TPH1, BDNF

GO Terms for genes affiliated with Mood Disorder

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Sources:
16Gene Ontology
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Cellular components related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADRA2A, HTR1B, HTR1A, HTR6, DRD4, GABRA1
2dendritic spineGO:04319710.7NOS1, NTRK2, DRD4

Biological processes related to Mood Disorder according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2HCRT, MAOA, CRH, GABRA1, HTR6, HTR1B
2negative regulation of cAMP biosynthetic processGO:03081811.0HTR1B, DRD4, ADRA2A
3regulation of neurotransmitter secretionGO:04692811.0HCRT, NTRK2, DRD4
4vasoconstrictionGO:04231011.0HTR1B, HTR1A, SLC6A4
5behavioral fear responseGO:00166211.0BDNF, HTR1A, DRD4
6negative regulation of adenylate cyclase activityGO:00719411.0DRD4, GALR1, ADRA2A
7feeding behaviorGO:00763111.0BDNF, CRH, NTRK2
8circadian rhythmGO:00762310.9CLOCK, SLC6A4, TPH1
9adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.9HTR1A, HTR1B
10regulation of serotonin secretionGO:01406210.9CRH, HTR1A
11response to immobilization stressGO:03590210.9TPH1, CRH
12fear responseGO:04259610.9ADRA2A, DRD4
13negative regulation of epinephrine secretionGO:03281110.8ADRA2A, CRH
14mechanoreceptor differentiationGO:04249010.8NTRK2, BDNF
15regulation of dopamine metabolic processGO:04205310.8HTR1A, DRD4
16negative regulation of norepinephrine secretionGO:01070010.7CRH, ADRA2A
17regulation of behaviorGO:05079510.7HTR1B, HTR1A
18negative regulation of potassium ion transportGO:04326710.7HCRT, NOS1
19synaptic transmission, dopaminergicGO:00196310.6DRD4, CRH
20neurotransmitter biosynthetic processGO:04213610.6NOS1, MAOA
21negative regulation of neuron apoptotic processGO:04352410.6BDNF, WFS1, NTRK2
22bone remodelingGO:04684910.3TPH1, HTR1B

Molecular functions related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00499310.7HTR6, HTR1A, HTR1B
2drug bindingGO:00814410.4SIGMAR1, GABRA1, DRD4, HTR1B

Products for genes affiliated with Mood Disorder

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  • Antibodies
  • Proteins
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Sources for Mood Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet