Mood Disorder malady

MedlinePlus: Most people feel sad or irritable from time to time. they may say they're in a bad mood. a mood disorder is different. it affects a person's everyday emotional state. nearly one in ten people aged 18 and older have mood disorders. these include major depressive disorder dysthymic disorder (a chronic, mild depression) bipolar disorder (also called manic depression) mood disorders can increase a person's risk for heart disease, diabetes, and other diseases. treatments include medication, psychotherapy, or a combination of both. with tretment, most people with mood disorders can lead productive lives.²³

MalaCards: Mood Disorder, also known as mood disorders, is related to schizophrenia and bipolar disorder. An important gene associated with Mood Disorder is BDNF (brain-derived neurotrophic factor), and among its related pathways are Neuroactive ligand-receptor interaction and Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling. The drug mood stabilizer [epc] and the compounds thapsigargin and testosterone have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are nervous system and normal.

Disease Ontology: A cognitive disorder that involves an excessive, irrational dread of everyday situations.⁶

Wikipedia: Mood disorder is the term designating a group of diagnoses in the Diagnostic and Statistical Manual of...⁴⁴ more...

Aliases & Descriptions:

mood disorder 6 mood disorders 32 23 43 unspecified episodic mood disorder 43

episodic mood disorder 6 mood disease 8

Diseases related to mood disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 771)

id	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	36.1	MTHFR, HTR2A, DRD3, DISC1, COMT
2	bipolar disorder	31.8	BDNF, HTR1A, SLC6A4
3	seasonal affective disorder	31.2	CLOCK, HTR1A, HTR2A, HTR2C, GNB3, TPH1
4	major affective disorder	31.0	XBP1, ATP2A2, HTR2A, HTR3A, TPH1, ACE
5	dysthymic disorder	31.0	MAOA, HTR2A, HCRT
6	insomnia	30.7	CLOCK, LEP, HTR1A, HTR2A, HTR2C, HTR3A
7	endogenous depression	29.8	MAOA, TRH, CRH, SLC6A4
8	substance abuse	29.8	CNR1, BDNF, MOBP, MAOA, MAOB, HTR1A
9	manic-depressive illness	29.7	INPP1, GSK3B, MAOA, MAOB, TPH1, DRD2
10	cushing's syndrome	29.7	NR3C1, NR3C2, CRH, POMC
11	schizoaffective disorder	29.5	RELN, CNR1, CLOCK, BHLHE41, BDNF, FXYD6
12	delusional disorder	29.5	DRD3, DRD4, TH
13	melancholia	29.3	AVPR1B, MAOA, TRH, CRH, PLP1, PRL
14	bipolar i disorder	29.2	CNR1, CLOCK, BHLHE41, BDNF, P2RX7, XBP1
15	tremor	29.1	CNR1, MTHFR, FMR1, CCK, HTR2A, HTR2C
16	adrenal gland hyperfunction	28.5	LEP, GHRL, TRH, NR3C1, NR3C2, CRH
17	narcolepsy	27.7	CLOCK, LEP, GRIN2A, IL1A, IL1RN, MAOA
18	obsessive-compulsive disorder	27.2	BDNF, GRIK2, GRIK3, GRIN1, IL6, MAOA
19	ataxia	26.0	VIP, MT-TK, FMR1, GRIK2, HTR1A, HTR3A
20	major depressive disorder	25.9	PDE4A, CNR1, CLOCK, BDNF, LEP, MTHFR
21	dementia	21.5	PDE4A, RELN, VIP, BDNF, MTHFR, S100B
22	cholesterol	19.3	RELN, CNR1, VIP, BDNF, LEP, MTHFR
23	neuronitis	18.5	PDE4A, RELN, CNR1, VIP, VIPR2, LIN7C
24	prostatitis	17.3	PDE4A, RELN, CNR1, VIP, VIPR2, CLOCK
25	attention deficit hyperactivity disorder	14.8	BDNF, FMR1, GRIN2A, MAOA, MAOB, HTR1B
26	nicotine dependence	14.8	CNR1, BDNF, ARRB1, GRM2, MAOA, MAOB
27	drug dependence	14.7	CNR1, BDNF, MAOA, HTR3A, DRD1, DRD2
28	neurotic disorder	14.7	BDNF, XBP1, MAOA, HTR1A, HTR2A, HTR3A
29	drug addiction	14.6	BDNF, DRD1, DRD2, DRD3, CREB1, CRH
30	personality disorder	14.6	MAOA, MAOB, HTR1B, TPH1, TPH2, DRD2
31	conduct disorder	14.5	PAWR, GRIN1, MAOA, TPH1, DRD2, DRD4
32	pathological gambling	14.5	GRIN1, MAOA, MAOB, DRD1, DRD2, DRD3
33	memory impairment	14.5	PDE4A, CNR1, BDNF, FMR1, GRIN1, MAOB
34	alcoholism	14.5	CNR1, GRIN1, GRIN2A, IL1RN, MAOA, MAOB
35	substance dependence	14.4	CNR1, BDNF, GRIA1, GRIK1, MAOA, HTR1B
36	gilles de la tourette syndrome	14.4	HTR3A, DRD2, DRD4, COMT, DBH, SLC6A3
37	cocaine dependence	14.4	CNR1, CLOCK, PAWR, GRM2, MAOB, HTR2C
38	post-traumatic stress disorder	14.4	CNR1, BDNF, FKBP5, MAOA, DRD2, NR3C1
39	sepiapterin reductase deficiency	14.4	TPH1, DRD2, NOS1, TH, SLC6A3, SLC18A2
40	opiate dependence	14.4	DRD2, DRD3, CREB1, COMT, TH, ADCY10
41	mental retardation syndrome	14.3	RELN, VIP, BDNF, FMR1, MAOA, HTR3A
42	antisocial personality disorder	14.3	GRIK3, MAOA, HTR1B, HTR2A, DRD2, DRD4
43	parkinson's disease	14.3	CNR1, PAWR, BDNF, FMR1, GSK3B, MAP2
44	cognitive disease	14.3	RELN, MAOA, MAOB, HTR1A, COMT
45	postural orthostatic tachycardia syndrome	14.3	NOS1, NOS3, DBH, SLC6A2, ADRB2, ADRA2C
46	lacrimal duct obstruction	14.3	PDE4A, AMBP, NOS1, NGFR, TAC1, NPY
47	advanced sleep phase syndrome	14.3	CLOCK, GPR50, TPH2, DAOA, HCRT, CSNK1E
48	growth mental deficiency syndrome of myhre	14.2	CLOCK, BDNF, LEP, XBP1, ARNTL, MAOA
49	supranuclear palsy	14.2	MOBP, MAP2, HTR1A, HTR3A, DRD2, CRHR1
50	enuresis	14.2	AVP, HTR2A, DRD4, NOS1, NOS3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mood stabilizer [epc]

MalaCards organs/tissues related to mood disorder:

²²

MGI Mouse Phenotypes related to mood disorder:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	INF	, RELN, CNR1, LIN7C, CLOCK, BHLHE40
2	normal phenotype	MP:0002873	INF	VIP, LIN7C, PAWR, BDNF, SAT1, AVP
3	mortality/aging	MP:0010768	INF	RELN, CNR1, LIN7C, PBRM1, BDNF, LEP
4	growth/size phenotype	MP:0005378	INF	RELN, CNR1, VIPR2, LIN7C, CLOCK, BDNF
5	hearing/vestibular/ear phenotype	MP:0005377	INF	BDNF, P2RX7, FZD3, FGF9, GRIA2,
6	reproductive system phenotype	MP:0005389	INF	VIP, VIPR2, CLOCK, LEP, , FZD3
7	behavior/neurological phenotype	MP:0005386	INF	RELN, CNR1, VIP, VIPR2, CLOCK, BHLHE40
8	cellular phenotype	MP:0005384	INF	RELN, CNR1, LIN7C, BHLHE40, BHLHE41, PAWR
9	hematopoietic system phenotype	MP:0005397	INF	BHLHE40, BHLHE41, PAWR, P2RX7, , ARNTL
10	liver/biliary system phenotype	MP:0005370	INF	CLOCK, SAT1, , GSK3B, IL6, IFNG
11	immune system phenotype	MP:0005387	INF	, VIPR2, BHLHE40, BHLHE41, PAWR, ARNTL
12	vision/eye phenotype	MP:0005391	INF	RELN, BDNF, LEP, MTHFR, FZD3, ARNTL
13	respiratory system phenotype	MP:0005388	INF	PBRM1, BDNF, FZD3, ARNTL, , TPH1
14	digestive/alimentary phenotype	MP:0005381	INF	RELN, CLOCK, BDNF, LEP, , FGF9
15	endocrine/exocrine gland phenotype	MP:0005379	INF	AVPR1B, FMR1, MAGEL2, IFNG, HTR1B, HTR2A
16	homeostasis/metabolism phenotype	MP:0005376	INF	CNR1, VIP, VIPR2, LIN7C, CLOCK, BDNF
17	taste/olfaction phenotype	MP:0005394	INF	, CNR1, BDNF, MAGEL2, , TPH2
18	renal/urinary system phenotype	MP:0005367	INF	LIN7C, BHLHE40, AVP, , ARNTL, FKBP5
19	integument phenotype	MP:0010771	INF	RELN, CNR1, CLOCK, BDNF, S100B, P2RX7
20	skeleton phenotype	MP:0005390	INF	CNR1, LEP, MTHFR, P2RX7, IL6, MCHR1
21	cardiovascular system phenotype	MP:0005385	INF	, CLOCK, PBRM1, LEP, P2RX7,
22	adipose tissue phenotype	MP:0005375	INF	CNR1, VIPR2, CLOCK, LEP, SAT1, ARNTL
23	muscle phenotype	MP:0005369	INF	RELN, LEP, , , ARNTL,
24	tumorigenesis	MP:0002006	INF	LEP, SAT1, , IL10, IL1A, IL1B
25	no phenotypic analysis	MP:0003012	INF	CNR1, CLOCK, BHLHE40, BDNF, MTHFR, INPP1

Articles related to mood disorder:

(show top 50)    (show all 213)

id	Title	Authors	Year	Affiliating Genes
1	Altered sirtuin deacetylase gene expression in patien ts with a mood disorder. (21349544)	Abe N.... Watanabe Y.	2011	SIRT2, SIRT1, SIRT6
2	No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders. (19475602)	Dempster E.L.... Barr C.L.	2010	ACE, EDN1
3	Anxiety and mood disorders in narcolepsy: a case-cont rol study. (20114128)	Fortuyn H.A.... Overeem S.	2010	HCRT
4	Genome-wide association study of suicide attempts in mood disorder patients. (21041247)	Perlis R.H.... Smoller J.W.	2010	ABI3BP
5	Meta-analysis of the association between the monoamin e oxidase-A gene and mood disorders. (20010318)	Fan M.... Zhang J.	2010	MAOA
6	No association between oxytocin or prolactin gene var iants and childhood-onset mood disorders. (20547007)	Strauss J.S.... Kennedy J.L.	2010	PRLR, PRL, OXTR
7	Genetic bases of comorbidity between mood disorders a nd migraine: possible role of serotonin transporter gene. (19936882)	Marino E.... Smeraldi E.	2010	SLC6A4
8	Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. (19931869)	Roger S.... Jiang L.H.	2010	P2RX7
9	Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. (19224106)	Kishi T.... Iwata N.	2009	CLOCK
10	The role of the tripartite glutamatergic synapse in t he pathophysiology and therapeutics of mood disorders. (19471044)	Machado-Vieira R.... Zarate C.A.	2009	SLC1A4
11	Cytokine polymorphisms in the pathophysiology of mood disorders. (19890236)	Clerici M.... Altamura A.C.	2009	TNF, IL6, IFNG
12	Wolframin gene H611R polymorphism: no direct association with suicidal behavior but possible link to mood disorders. (19328217)	Zalsman G.... Mann J.J.	2009	WFS1
13	Expression and association analyses of promoter varia nts of the neurogenic gene HES6, a candidate gene for mood disorder susceptibil ity and antidepressant response. (19481584)	Glubb D.M.... Kennedy M.A.	2009	HES6
14	Disruption of the circadian timing systems: molecular mechanisms in mood disorders. (19708722)	Mendlewicz J.	2009	CLOCK, GPR50, ARNTL
15	The fibroblast growth factor family and mood disorders. (18497097)	Akil H.... Watson S.J.	2008	BDNF
16	Association study of serotonin system genes in childhood-onset mood disorder. (18349694)	Shaikh S.A.... Kennedy J.L.	2008	HTR1B, SLC6A4, HTR2A
17	Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders. (19016479)	Misener V.L.... Barr C.L.	2008	IL1B
18	Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders. (18449864)	Mill J.... Barr C.	2008	ESR1
19	G72/G30 (DAOA) and juvenile-onset mood disorders. (19089835)	Gomez L.... Barr C.L.	2008	DAOA
20	Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome. (17591512)	Bourgeois J.A.... Hagerman R.J.	2007	FMR1
21	How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. (17512705)	Artioli P.... Smeraldi E.	2007	PER3
22	Glia mechanisms in mood regulation: a novel model of mood disorders. (17225169)	Lee Y.... Shekhar A.	2007	SLC1A2
23	Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (17909131)	Dempster E.L.... Barr C.L.	2007	AVPR1B
24	Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders. (19300594)	Watson S.... Ferrier I.N.	2007	CRH
25	Distribution of serotonin transporter labeled fibers in amygdaloid subregions: implications for mood disorders. (16414028)	O'Rourke H.... Fudge J.L.	2006	SLC6A4
26	Microarray analysis of cultured human brain aggregates following cortisol exposure: implications for cellular functions relevant to mood disorders. (16844382)	Salaria S.... Everall I.P.	2006	FGF9
27	A neurotrophic model for stress-related mood disorders. (16631126)	Duman R.S.... Monteggia L.M.	2006	BDNF
28	Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families. (16526032)	Burcescu I.... Barr C.L.	2006	ADRA1B, ADRA2C, ADRA2A
29	Diagnosis and treatment of mood disorders in persons with epilepsy. (15791142)	Gilliam F.G.	2005	HTR3A
30	Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. (15389758)	Adams J.H.... Barr C.L.	2005	NTRK2
31	Association study of NOTCH4 gene polymorphisms with schizophrenia and mood disorders in mixed pedigrees (16378929)	Wang Z.W.... Jing S.D.	2005	NOTCH4
32	The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis. (15860340)	Lopez Leon S.... Van Duijn C.M.	2005	DRD4
33	Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. (15657645)	Hashimoto R.... Kunugi H.	2005	FZD3
34	Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders. (15111989)	Serretti A.... Smeraldi E.	2004	SLC6A4
35	BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population. (15118355)	Pae C.U.... Lee C.	2004	PLA2G4A
36	Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders. (15274037)	Serretti A.... Zanardi R.	2004	TPH1, SLC6A4
37	Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. (15564899)	Tan E.C.... Mahendran R.	2004	MTHFR
38	Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders. (12782971)	Serretti A.... Nappi G.	2003	COMT, TH, WFS1
39	Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample. (12886033)	Yen F.C.... Tsai S.J.	2003	SLC6A4
40	Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. (11983185)	Ichimiya T.... Shibuya H.	2002	SLC6A4
41	Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. (11578639)	Cusin C.... Smeraldi E.	2001	TPH1, SLC6A4
42	Changes in the regression slope correlating between u rinary contents of alpha-1-microglobulin and ulinastatin and its relation to se verity in mood disorders. (11882184)	Shikimi T.... Mitsuoka S.	2001	AMBP
43	Future therapeutic targets in mood disorders: the glucocorticoid receptor. (11059990)	McQuade R.... Young A.H.	2000	NR3C1
44	Clinical predictors of acute response with quetiapine in psychotic mood disorders. (10817103)	Zarate C.A.... Zapatel J.	2000	NOS1
45	No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders. (10482339)	Serretti A.... Smeraldi E.	1999	HTR2A
46	Genetic association between mood disorder and monoamine oxidase gene (11715502)	Lin S.... Jiang K.	1999	MAOA, MAOB
47	Tryptophan hydroxylase gene and response to lithium prophylaxis in mood disorders. (10504005)	Serretti A.... Smeraldi E.	1999	TPH1
48	Dopamine receptor D4 gene is associated with delusional symptomatology in mood disorders. (9754691)	Serretti A.... Smeraldi E.	1998	DRD4
49	Dopamine receptor D3 gene and response to lithium prophylaxis in mood disorders. (11281956)	Serretti A.... Smeraldi E.	1998	DRD3
50	Cerebrospinal fluid neuropeptides in mood disorder and dementia. (1352520)	Banki C.M.... Nemeroff C.B.	1992	CRH

Genes related to mood disorder according to GeneCards:

(show top 50)    (show all 167)

id	Symbol	Description	Score	GeneCards Section Context
1	BDNF	brain-derived neurotrophic factor	11.1	Publications, Summaries
2	SIGMAR1	sigma non-opioid intracellular receptor 1	11.1	Summaries
3	NTRK2	neurotrophic tyrosine kinase, receptor, type 2	11.1	Publications, Summaries
4	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
5	TPH1	tryptophan hydroxylase 1	11.0	Publications
6	DAOA	D-amino acid oxidase activator	11.0	Publications
7	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	11.0	Publications
8	DISC1	disrupted in schizophrenia 1	11.0	Publications
9	MAOA	monoamine oxidase A	11.0	Publications
10	CLOCK	clock homolog (mouse)	11.0	Publications
11	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
12	WFS1	Wolfram syndrome 1 (wolframin)	11.0	Publications
13	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
14	DRD4	dopamine receptor D4	11.0	Publications
15	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
16	CRH	corticotropin releasing hormone	11.0	Publications
17	POLG	polymerase (DNA directed), gamma	11.0	Publications
18	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
19	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0	Publications
20	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
21	ADRA2A	adrenoceptor alpha 2A	11.0	Publications
22	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
23	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
24	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
25	MAOB	monoamine oxidase B	11.0	Publications
26	DRD1	dopamine receptor D1	11.0	Publications
27	DRD3	dopamine receptor D3	11.0	Publications
28	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
29	NTF3	neurotrophin 3	11.0	Publications
30	NGFR	nerve growth factor receptor	11.0	Publications
31	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	11.0	Publications
32	GAL	galanin prepropeptide	11.0	Publications
33	ADORA1	adenosine A1 receptor	11.0	Publications
34	COMT	catechol-O-methyltransferase	11.0	Publications
35	TH	tyrosine hydroxylase	11.0	Publications
36	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
37	TPH2	tryptophan hydroxylase 2	11.0	Publications
38	GDNF	glial cell derived neurotrophic factor	11.0	Publications
39	TACR1	tachykinin receptor 1	11.0	Publications
40	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
41	MAP2	microtubule-associated protein 2	11.0	Publications
42	NPY	neuropeptide Y	11.0	Publications
43	DRD2	dopamine receptor D2	11.0	Publications
44	RELN	reelin	11.0	Publications
45	CREB1	cAMP responsive element binding protein 1	11.0	Publications
46	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
47	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
48	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
49	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
50	POMC	proopiomelanocortin	11.0	Publications

Pathways related to mood disorder according to GeneDecks:

(show top 50)    (show all 103)

id	Pathway	Score	Top Affiliating Genes
1	Neuroactive ligand-receptor interaction20	INF	CNR1, VIPR2, LEP, P2RX7, AVPR1B, GRIA1
2	Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling41	INF	, GRIA2, GRIA1, , DRD1, CREB1
3	Intracellular Calcium Signaling36	INF	HTR2A, CACNA1C, , , HTR2C, HTR3A
4	Dopamine-DARPP32 Feedback onto cAMP Pathway36	INF	NOS1, CSNK1E, ADCY8, ADCY9, CACNA1C,
5	Signaling in Gap Junctions36	INF	DRD1, CTNNB1, , CSNK1E, ADCY9, ADCY8
6	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	INF	NOS1, TAC1, , , , CREB1
7	cAMP Pathway36	INF	, , PLA2G4A, , CREB1,
8	Pathogenesis of ALS36	INF	SLC1A2, , GRIA2, , GRIA3, GRIA1
9	p38 Signaling36	INF	, GNB3, CCL2, GNRH1, , BDNF
10	MAPK Signaling36	INF	NTRK2, ADCY9, ADCY8, NGFR, , CREB1
11	PEDF Induced Signaling36	INF	IL6, BDNF, SOD2, , , IL10
12	Signaling Involved in Cardiac Hypertrophy36	INF	IL6, CREB1, , , ADRA1B, ADRA2A
13	Arginine and proline metabolism20	INF	MAOB, NOS1, SAT1, MAOA, GLUL, SMS
14	ERK Signaling36	INF	IL10, PPP1R9B, NTRK3, , IL6, CACNA1C
15	Activation of cAMP-Dependent PKA36	INF	, CACNA1C, , ADRA2C, ADCY8, ADRA1B
16	Sympathetic Nerve Pathway (Neuroeffector Junction)34	INF	, TH, , NPY, SLC6A2, ADRA2C
17	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	INF	OXTR, , AVPR1B, MCHR1, , HCRT
18	African trypanosomiasis20	INF	IL10, IL1B, IL6, IFNG, ,
19	Activation of PKC through GPCR36	INF	CREB1, , NGFR, NTRK3, ADCY8, ADCY9
20	Melanogenesis20	INF	GSK3B, , CTNNB1, CREB1, , EDN1
21	Activation of PKA through GPCR36	INF	GNRH1, , ADCY8, ADRA1B, ADRA2A, ADCY9
22	Akt Signaling36	INF	NTF3, NTRK3, , NGFR, GABRG2, GABRA6
23	Amine ligand-binding receptors38	11.2	HTR1A, HTR1B, HTR2A, HTR2C, HTR5A, HTR6
24	BMAL1:CLOCK/NPAS2 Activates Circadian Expression38	10.8	PER1, CRY2, BHLHE40, DBP, BHLHE41, PER2
25	Metabolic States and Circadian Oscillators36	10.7	ARNTL, CLOCK, CRY2, CRY1, PER1, NPAS2
26	Circadian Clock in Mammals36	10.5	CLOCK, ARNTL, NR1D1, CRY1, CRY2, CSNK1E
27	Circadian rhythm - mammal20	10.4	CLOCK, BHLHE40, BHLHE41, ARNTL, NR1D1, CRY1
28	Selected targets of GCR-alpha10	9.4	IL1B, NR3C1, GLUL, MAP2, LEP, NOTCH4
29	Glutamatergic synapse20	INF	GLUL, PLA2G4A, , , SLC1A2, ADCY8
30	Neuroscience3	INF	, SLC1A4, WFS1, , , GABBR1
31	Selected targets of CREB110	INF	CRH, CCK, MAP2, CREB1, , PER1
32	IP3 Pathway36	INF	, , NGFR, , CREB1, CACNA1C
33	CDK5 Pathway36	INF	DRD2, DRD3, DRD4, NTRK2, PPP1R9B, NGFR
34	GABA signaling in brain10	INF	GABRA1, GABBR2, GAD1, GABBR1, , GABRA6
35	G alpha (q) signalling events38	INF	TAC1, OXT, OXTR, PROK2, PROKR2, TACR1
36	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling10	INF	, GRIA2, , CSNK1E, , DRD1
37	Calcium signaling pathway20	INF	P2RX7, AVPR1B, , , , HTR2A
38	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics34	INF	, , GNB3, CACNA1C, ADCY8,
39	CREB Pathway36	INF	BDNF, , GNB3, GNRH1, NTF3, NTRK2
40	Long-term depression20	INF	GRIA1, , PLA2G4A, CRH, , GRIA3
41	Molecular Mechanisms of Cancer36	INF	BDNF, FZD3, IL6, , GNB3, GNRH1
42	Metabolism of amino acids and derivatives38	INF	, TH, NQO1, SMS, TPH2, TPH1
43	Phospholipase-C Pathway36	INF	NGFR, ADCY8, ADCY9, , , PLA2G4A
44	Endothelin-1 Signaling Pathway36	INF	EDN1, NOS1, , , NTRK3,
45	Ca, cAMP and Lipid Signaling3	INF	GNB3, PLA2G4A, , , , WFS1
46	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	INF	MAOA, HTR1A, HTR2A, HTR6, , TPH1
47	Chagas disease (American trypanosomiasis)20	INF	TNF, , , , IFNG, IL1B
48	Glutamic acid signaling10	INF	, GLUL, SLC1A2, GAD1, GAD2, GRM3
49	CRHR Pathway36	INF	BDNF, CACNA1C, , , GNB3, CREB1
50	ERK5 Signaling36	INF	NTRK3, , IL6, GNB3, CREB1, NGFR

Compounds related to mood disorder according to GeneDecks:

(show top 50)    (show all 654)

id	Compound	Score	Top Affiliating Genes
1	thapsigargin32 42	INF	CNR1, VIP, BDNF, , , CCK
2	testosterone32 9 18 9	INF	VIP, BDNF, MTHFR, S100B, FMR1, FKBP5
3	thymidine32 18	INF	VIP, BDNF, MTHFR, S100B, IL10, IL1A
4	formaldehyde32 18	INF	S100B, IL1A, IL1RN, CCL2, GNRH1, GLUL
5	venlafaxine32 34 9 18 9	INF	BDNF, FKBP5, HTR1A, HTR1B, HTR2A, HTR3A
6	fenfluramine32 9 9	INF	LEP, CCK, HTR1A, HTR1B, HTR2A, HTR2C
7	pge232	INF	, VIP, SAT1, P2RX7, IL1A, IL1RN
8	clozapine32 34 9 9	INF	LEP, IL10, HTR1A, HTR2A, HTR2C, HTR3A
9	octreotide32 42 9 9	INF	VIP, CCK, GNRH1, GHRL, , DRD2
10	alanine32	INF	CNR1, VIP, SAT1, S100B, AVP, ARNTL
11	naloxone32 34 9 9	INF	CNR1, VIP, LEP, IL1A, CCK, GNRH1
12	quinpirole32	INF	CNR1, , DRD1, DRD2, DRD3, CREB1
13	mifepristone32 42 9 9	INF	FKBP5, IL1B, CCL2, GNRH1, GLUL, ESR1
14	kainate32	INF	CNR1, BDNF, GRIA1, GRIA2, GRIA3, GRIK1
15	bupropion32 34 9 18 9	INF	CNR1, MAOB, GHRL, DRD2, DRD3, CYP2D6
16	ibmx32	INF	, VIP, BDNF, IL1B, CCK,
17	morphine32 9 9	INF	CNR1, VIP, , GRIA1, GRIA2,
18	ethanol32 34 9 18 9	INF	BDNF, S100B, AVP, , , MAP2
19	valproate32	INF	RELN, BDNF, , GSK3B, , NTF3
20	ropinirole32 9 9	12.5	MAOB, HTR1A, HTR1B, HTR2A, HTR2C, DRD1
21	l-nmma32	10.1	VIP, IL1RN, CCK, GHRL, CRH, NOS1
22	aripiprazole32 34 9 18 9	13.8	HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR6
23	paliperidone32 9 9	11.6	HTR1A, HTR2A, HTR2C, DRD1, DRD2, DRD3
24	6-hydroxydopamine32	INF	VIP, BDNF, MAOA, MAOB, DRD1, DRD2
25	acetylcholine32 9 18 9	INF	, CNR1, VIP, BDNF, LEP, S100B
26	nefazodone34 32 9 9	INF	FKBP5, HTR1A, HTR2A, HTR2C, HTR3A, HMGCR
27	gnrh32	INF	LEP, CCL2, HTR2C, GHRL, , CTNNB1
28	ketanserin32	INF	BDNF, IL1A, HTR1A, HTR1B, HTR2A, HTR2C
29	cocaine32 9 9	INF	, CNR1, BDNF, LEP, S100B, MOBP
30	glutamate32	INF	CNR1, VIP, LEP, MTHFR, P2RX7, FMR1
31	ribonucleic acid32	INF	, , IL1A, IL1B, IL1RN, CCL2
32	epinephrine32 9 18 9	INF	, VIP, BDNF, LEP, IL1A, IL1RN
33	catecholamine32	INF	, VIP, BDNF, S100B, AVP, MAOA
34	glucose32	INF	, PAWR, SAT1, S100B, P2RX7,
35	creatinine32	INF	BDNF, LEP, MTHFR, S100B, FMR1, IL1A
36	norepinephrine32 9 18 9	INF	, CNR1, VIP, BDNF, LEP, S100B
37	choline32 9 18 9	INF	VIP, MTHFR, S100B, P2RX7, MAP2, MAOB
38	mhpg32	INF	BDNF, MAOA, MAOB, GNRH1, DRD4, CRH
39	levodopa32 9 9	INF	CNR1, BDNF, MAOA, MAOB, HTR1A, HTR1B
40	fluvoxamine32 34 9 9	INF	CLOCK, BDNF, MAOA, HTR1A, HTR2A, HTR3A
41	sodium32 18	INF	BDNF, XK, P2RX7, AVP, , AMBP
42	olanzapine32 34 9 18 9	INF	BDNF, LEP, HTR1A, HTR1B, HTR2A, HTR2C
43	progesterone32 42 9 18 9	INF	, S100B, FKBP5, GSK3B, MAP2, GNRH1
44	calcium32 9 18 9	INF	, RELN, CNR1, VIP, LIN7C, BDNF
45	h2o232	INF	, VIP, BDNF, LEP, SAT1, IL1RN
46	clomipramine32 34 9 9	INF	FKBP5, IL10, MAOA, HTR1A, HTR2A, HTR2C
47	atropine32 9 9	INF	VIP, CCK, , GHRL, , DRD1
48	phosphoinositide32	INF	RELN, BDNF, , , GRM3,
49	cysteine32	INF	MTHFR, XK, S100B, AVP, , MAOB
50	dbc-amp32	INF	, VIP, BDNF, S100B, IL1B, MAP2

Cellular components related to mood disorder according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	OXT, TAC1, TF, HCRT, EDN1,
2	terminal button	GO:043195	INF	ADORA1, P2RX7, GRIA2, GRIA3, GRIK2,
3	plasma membrane	GO:005886	INF	COMT, , ESR1, HSPA8, GNB3,
4	secretory granule	GO:030141	INF	GAL, POMC, , OXT, TF, HCRT
5	extracellular space	GO:005615	INF	TNF, , CRH, EDN1, ABI3BP, ACE
6	dendritic spine	GO:043197	INF	GABBR1, , NOS1, PPP1R9B, DRD4, DRD1
7	axon	GO:030424	INF	, , ADRA2C, ADCY10, GAP43, GAD2
8	dendrite	GO:030425	INF	TACR1, , CPLX2, WFS1, ADCY10, DRD2
9	dendritic shaft	GO:043198	10.3	GABBR1, HTR2A, MAP2, GRIA3, GRIA2, GSK3B
10	asymmetric synapse	GO:032279	10.0	ADORA1, ADORA2A, GRIA3, GRIA2
11	perikaryon	GO:043204	10.0	TH, DRD2, HTR5A, CCK, GRIK3, GRIK2
12	integral to plasma membrane	GO:005887	INF	ADORA1, ADORA2A, ADRA2C, , SIGMAR1, SLC1A4
13	postsynaptic membrane	GO:045211	INF	GABRA1, GABRG2, GABRA6, GABBR2, GABBR1, ADORA1
14	cell junction	GO:030054	INF	HCRT, SIGMAR1, GABBR1, GABBR2, GABRA6, GABRG2
15	postsynaptic density	GO:014069	INF	NTRK2, NR3C1, , ADORA2A, ADORA1, CACNA1C
16	neuronal cell body	GO:043025	INF	CCL2, MAP2, GRIA1, GSK3B, P2RX7, S100B
17	cell surface	GO:009986	INF	PRLR, TACR1, ABCB1, NGFR, NOTCH4,
18	presynaptic membrane	GO:042734	INF	GAD2, GABBR1, ADORA1, ADORA2A, GRM3, GRM2
19	cytosol	GO:005829	INF	RND1, NGFR, COMT, NOTCH4, , NOS1

Biological processes related to mood disorder according to GeneDecks:

(show top 50)    (show all 117)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:042493	INF	CTNNB1, DRD3, DRD2, DRD1, TNF, HTR2C
2	sensory perception of pain	GO:019233	INF	, CNR1, P2RX7, PROK2, EDN1, TAC1
3	response to ethanol	GO:045471	INF	CNR1, , GABBR1, , TACR1, TH
4	memory	GO:007613	INF	SLC6A4, S100B, , IL1B, CNR1, IL1RN
5	response to estradiol stimulus	GO:032355	INF	, OXTR, OXT, , CTNNB1, ESR1
6	glutamate receptor signaling pathway	GO:007215	INF	GRIK2, GRIK3, GRIA3, , GRIK1,
7	G-protein coupled receptor signaling pathway	GO:007186	INF	ADRA1B, VIP, AVPR1B, CCL2, GPR50, MCHR1
8	locomotory behavior	GO:007626	INF	ADRA1B, DRD3, TH, AVP, ,
9	neuropeptide signaling pathway	GO:007218	INF	HCRT, GAL, NPY, , HCRTR1, POMC
10	prepulse inhibition	GO:060134	INF	DRD1, , ADORA2A, DRD2, DRD3,
11	anti-apoptosis	GO:006916	INF	NGFR, NR3C1, , , GSK3B, TNF
12	female pregnancy	GO:007565	INF	OXTR, LEP, IL1RN, , AMBP, GNRH1
13	response to hypoxia	GO:001666	INF	IL1B, IL1A, ADORA1, SLC6A4, TH, EDN1
14	regulation of sensory perception of pain	GO:051930	INF	OXT, , EDN1, CCK, IL1A, IL10
15	feeding behavior	GO:007631	11.0	HCRTR1, GAL, NPY, HCRTR2, BDNF, MCHR1
16	synaptic transmission, dopaminergic	GO:001963	11.0	CRH, ADORA2A, TH, DRD4, DRD3, DRD2
17	circadian regulation of gene expression	GO:032922	10.9	DRD2, DRD3, PER1, BHLHE41, BHLHE40, CLOCK
18	behavioral response to cocaine	GO:048148	10.8	DRD2, DRD4, ADRA1B, DRD1, DRD3
19	circadian rhythm	GO:007623	10.7	TPH2, PER3, ARNTL, ARNTL2, NR1D1, NR3C1
20	positive regulation of glutamate secretion	GO:014049	10.6	P2RX7, AVP, AVPR1B, NR3C1, ADORA2A
21	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.6	HTR1B, HTR2A, DRD2, GRIK3, ADORA1, GRIK2
22	positive regulation of blood pressure	GO:045777	10.5	OXTR, TACR1, OXT, AVPR1B, CNR1, ADORA1
23	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	10.4	CNR1, NPY, DRD1, HTR5A, HTR1B, CCL2
24	positive regulation of renal sodium excretion	GO:035815	10.3	OXT, DRD2, EDN1, TACR1, TAC1, ADORA2A
25	negative regulation of blood pressure	GO:045776	10.1	CNR1, NPY, OXT, DRD3, ADORA1, DRD2
26	elevation of cytosolic calcium ion concentration	GO:007204	9.6	TAC1, OXTR, PROK2, CACNA1C, OXT, AVP
27	response to glucocorticoid stimulus	GO:051384	8.4	CCL2, PLA2G4A, OXT, TNF, TPH2, IL6
28	positive regulation of apoptotic process	GO:043065	INF	CTNNB1, GAL, ADCY10, , , SIRT1
29	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GO:007188	INF	, ADORA2A, ADRA1B, , AVPR1B,
30	visual learning	GO:008542	INF	, HMGCR, ADRA1B, , DRD3, DRD1
31	aging	GO:007568	INF	, , NR3C1, TSPO, HMGCR, IL1B
32	eating behavior	GO:042755	INF	DRD1, TACR1, OXTR, ADORA2A, HCRT, OXT
33	regulation of excitatory postsynaptic membrane potential	GO:060079	INF	GHRL, ADORA1, ADORA2A, , HCRT,
34	activation of adenylate cyclase activity	GO:007190	INF	, , , NTRK2, DRD1, VIPR2
35	signal transduction	GO:007165	INF	GRIA2, , NR3C1, , CREB1, CRH
36	neurotransmitter biosynthetic process	GO:042136	INF	GAD2, TH, , GAD1, NOS1, MAOA
37	synaptic transmission	GO:007268	INF	GNB3, HTR6, HTR3A, HTR2C, HTR2A, HTR1B
38	positive regulation of synaptic transmission, glutamatergic	GO:051968	INF	DRD1, NTRK2, RELN, ADORA2A, , OXTR
39	response to nicotine	GO:035094	INF	DRD2, AVP, GABBR1, , TACR1, CNR1
40	negative regulation of adenylate cyclase activity	GO:007194	INF	GRM2, GRM3, GABBR2, GABBR1, ADRA2A, DRD3
41	response to cocaine	GO:042220	INF	, CNR1, , HTR1B, DRD2, DRD3
42	inflammatory response	GO:006954	INF	IL1B, ADORA2A, PROK2, TAC1, , GAL
43	dopamine metabolic process	GO:042417	INF	, DRD1, DRD2, DRD3, DRD4
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IL1B, NTF3, CREB1, NOS1, DBP, POMC
45	cell-cell signaling	GO:007267	INF	, IL10, POMC, TAC1, IL1B, GNRH1
46	response to amphetamine	GO:001975	INF	, , DRD1, DRD2, DRD3, DRD4
47	response to morphine	GO:043278	INF	, ADRA1B, DRD2, IL1B, CNR1, TAC1
48	negative regulation of neuron apoptotic process	GO:043524	INF	BDNF, GRIK2, , NTF3, NTRK2, WFS1
49	long-term memory	GO:007616	INF	TACR1, CRH, , DRD2, RELN, GRIA1
50	social behavior	GO:035176	INF	, OXTR, SLC6A4, , , DRD4

Molecular functions related to mood disorder according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	ionotropic glutamate receptor binding	GO:035255	INF	, , CTNNB1, DRD2, GSK3B
2	dopamine binding	GO:035240	INF	, , DRD4, DRD3, DRD2, DRD1
3	extracellular-glutamate-gated ion channel activity	GO:005234	INF	, , GRIK3, GRIK2, GRIK1, GRIA3
4	protein binding	GO:005515	INF	ACE, TIMELESS, TH, TF, TACR1, CSNK1E
5	protein homodimerization activity	GO:042803	INF	NR3C1, , TIMELESS, PRLR, SLC6A4,
6	monoamine transmembrane transporter activity	GO:008504	INF	, SLC6A4, , SLC6A2
7	serotonin binding	GO:051378	11.0	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A, MAOA
8	serotonin receptor activity	GO:004993	10.9	HTR5A, HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
9	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.6	DRD4, DRD3, DRD2
10	NAD-dependent histone deacetylase activity	GO:017136	10.5	SIRT6, SIRT2, SIRT1
11	glutamate decarboxylase activity	GO:004351	10.5	GAD2, GAD1, GLUL
12	protein binding transcription factor activity	GO:000988	10.4	CRY1, CRY2, PER1, PER2
13	glutamate receptor activity	GO:008066	10.3	GRM3, GRM2, GRIK3, GRIA2, GRIA1
14	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	GO:004971	10.1	GRIA3, GRIA2, GRIA1
15	kainate selective glutamate receptor activity	GO:015277	10.1	GRIK3, GRIK2, GRIK1, GRIA2, GRIA1
16	receptor binding	GO:005102	INF	GDNF, ADCYAP1, , NPY, POMC, RND1
17	signal transducer activity	GO:004871	INF	PER3, PER2, PER1, NPAS2, NGFR,
18	hormone activity	GO:005179	INF	POMC, PRL, EDN1, , CRH, GNRH1
19	neuropeptide hormone activity	GO:005184	INF	GAL, ADCYAP1, NPY, HCRT, CRH,
20	growth factor activity	GO:008083	INF	GDNF, , NTF3, IL6, IL1B, IL10
21	drug binding	GO:008144	INF	CNR1, GABRA1, , SIGMAR1, ,