MCID: MDD011
MIFTS: 64

Mood Disorder malady

Neuronal diseases category

Summaries for Mood Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Most people feel sad or irritable from time to time. they may say they're in a bad mood. a mood disorder is different. it affects a person's everyday emotional state. nearly one in ten people aged 18 and older have mood disorders. these include major depressive disorder dysthymic disorder (a chronic, mild depression) bipolar disorder (also called manic depression) mood disorders can increase a person's risk for heart disease, diabetes, and other diseases. treatments include medication, psychotherapy, or a combination of both. with treatment, most people with mood disorders can lead productive lives.

MalaCards: Mood Disorder, also known as mood disorders, is related to bipolar disorder and schizophrenia. An important gene associated with Mood Disorder is BDNF (brain-derived neurotrophic factor), and among its related pathways are Circadian entrainment and Signaling by GPCR. The drug mood stabilizer [epc] and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, cortex and brain, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:63 Mood disorder is a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM... more...

Aliases & Classifications for Mood Disorder

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

mood disorder 8
mood disorders 44 33 60
unspecified episodic mood disorder 60
episodic mood disorder 8


External Ids:

Disease Ontology8 DOID:3324
ICD9CM27 296.7

Related Diseases for Mood Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mood Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.4NOS1, SLC6A4
2schizophrenia31.2NTRK2, MAOA, HCRT, CLOCK, DAOA, SLC6A4
3anxiety disorder30.9BDNF, HTR1A, CRH, MAOA, SLC6A4, TPH1
4personality disorder30.9HTR1B, DRD4, MAOA, SLC6A4, TPH1
5psychotic disorder30.8NOS1, TPH1, SLC6A4, DAOA, MAOA, BDNF
6schizoaffective disorder30.6NOS1, BDNF, DRD4, DAOA, SLC6A4
7obsessive-compulsive disorder30.5BDNF, HTR1B, HTR1A, DRD4, MAOA, SLC6A4
8melancholia30.5MAOA, CRH
9borderline personality disorder30.4HTR1B, MAOA, SLC6A4, TPH1
10multiple sclerosis30.4HCRT, NTRK2, BDNF
11substance abuse30.3SLC6A4, CRH, DRD4
12migraine30.2HTR1B, HTR1A, DRD4, MAOA, HCRT, SLC6A4
13attention deficit hyperactivity disorder30.2TPH1, ADRA2A, SLC6A4, MAOA, DRD4, HTR1B
14substance dependence30.2TPH1, SLC6A4, DRD4
15panic disorder30.2HTR1A, CRH, SLC6A4
16pathological gambling30.2DRD4
17eating disorder30.1BDNF, HTR1A, CRH, NTRK2, HCRT, SLC6A4
18seasonal affective disorder30.1HTR1A, DRD4, CRH, SLC6A4, TPH1
19alcohol dependence30.1HTR1B, DRD4, CRH, MAOA, SLC6A4
20social phobia30.1HTR1A, MAOA, SLC6A4
21temporal lobe epilepsy30.1BDNF, HTR1A, NTRK2
22dysthymic disorder30.1MAOA, HCRT
23generalized anxiety disorder30.1HTR1A, SLC6A4
24developmental disabilities30.1BDNF, HTR1A
25alcohol abuse30.1SLC6A4
26alzheimer's disease29.9GALR1, DRD4, HTR6, HTR1A, BDNF, CRH
27dementia29.9BDNF, HTR1A, NTRK2, MAOA, HCRT, NOS1
28nicotine dependence29.9DRD4, NTRK2, SLC6A4
29endogenous depression29.9CRH, MAOA
30narcolepsy29.9HCRT, CLOCK
31cocaine dependence29.9SLC6A4
32fragile x syndrome29.9SLC6A4
33major depressive disorder10.6
34bipolar i disorder10.4
35sexual disorder10.3
36sleep disorder10.3
37borna disease10.2
38neuronitis10.2
39delusional disorder10.2
40physical disorder10.2
41thyroiditis10.2
42adjustment disorder10.2
43alexithymia10.1
44breast cancer10.1
45dissociative disorder10.1
46intellectual disability10.1
47mitochondrial disorders10.1
48obesity10.0GNB3, HTR1A, DRD4, GALR1, CRH, NTRK2
49parkinson's disease10.0BDNF, HTR1B, HTR1A, TPH1, NOS1, SLC6A4
50anorexia nervosa10.0TPH1, SLC6A4, HCRT, BDNF, HTR1A, DRD4

Graphical network of the top 20 diseases related to Mood Disorder:



Diseases related to mood disorder

Clinical Features for Mood Disorder

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Drugs & Therapeutics for Mood Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mood Disorder

Drug clinical trials:

Search ClinicalTrials for Mood Disorder

Search NIH Clinical Center for Mood Disorder

Search CenterWatch for Mood Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mood Disorder

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Anatomical Context for Mood Disorder

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32MalaCards
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MalaCards organs/tissues related to Mood Disorder:

32
Heart, Cortex, Brain, Pituitary, Temporal lobe, Prefrontal cortex, Amygdala, Cingulate cortex, Thyroid, Testes, Breast, Monocytes, Liver, Hypothalamus, Skin, Ovary, Prostate, Kidney, Eye, Endothelial, Whole blood, Cerebellum

Animal Models for Mood Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mood Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.6TPH1, BDNF, HTR1B, HTR1A, HTR6, DRD4
2MP:000537611.5CRH, GABRA1, DRD4, HTR6, HTR1A, BDNF
3MP:000363111.3BDNF, GNB3, HTR1A, DRD4, GABRA1, CRH
4MP:000537811.1CRH, GABRA1, HTR6, HTR1B, BDNF, WFS1
5MP:000287310.9GABRA1, CRH, NTRK2, SLC6A4, NOS1, ADRA2A
6MP:000538510.7HTR1B, HTR1A, MAOA, HCRT, CLOCK, SLC6A4

Publications for Mood Disorder

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Sources:
50PubMed
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Articles related to Mood Disorder:

(show top 50)    (show all 813)
idTitleAuthorsYear
1
Mood congruence phenomenon in acutely symptomatic mania bipolar I disorder patients with and without psychotic symptoms. (23189939)
2013
2
Specialised mood disorder clinic v. standard care for out-patients with bipolar disorder. (23999486)
2013
3
The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. (22752684)
2013
4
What is the mathematical description of the treated mood pattern in bipolar disorder? (24009579)
2013
5
Evaluation of the unique and specific contributions of dimensions of the triple vulnerability model to the prediction of DSM-IV anxiety and mood disorder constructs. (23611077)
2013
6
What lies behind postnatal depression: is it only a mood disorder? (22686224)
2012
7
Residual memory dysfunction in recurrent major depressive disorder--a longitudinal study from Juntendo University Mood Disorder Project. (22832170)
2012
8
Alexithymia among Arab mothers of disabled children and its correlation with mood disorders. (22964812)
2012
9
Use of ultra-brief pulse electroconvulsive therapy to treat severe postnatal mood disorder. (23014119)
2012
10
Sexual obsessions and suicidal behaviors in patients with mood disorders, panic disorder and schizophrenia. (23110965)
2012
11
Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study. (21303731)
2011
12
Incidence and risk factors of suicide reattempts within 1 year after psychiatric hospital discharge in mood disorder patients. (22253548)
2011
13
Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia. (19913919)
2010
14
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (20072116)
2010
15
No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. (20547007)
2010
16
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. (19224106)
2009
17
CSF 5-HIAA and DST non-suppression--orthogonal biologic risk factors for suicide in male mood disorder inpatients. (19062105)
2009
18
Diagnosis and treatment of mood disorders in adults with developmental disabilities. (18726158)
2008
19
Interaction between BDNF and serotonin: role in mood disorders. (17882234)
2008
20
Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder. (18543122)
2008
21
Mood disorder following DBS of the left amygdaloid region in a dystonia patient with a dislodged electrode. (17987655)
2008
22
Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: implications for postpartum mood disorder. (17337328)
2007
23
The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders. (16936714)
2007
24
Lack of association between polymorphisms in the 5' upstream region of the DISC1 gene and mood disorders. (18075479)
2007
25
Aromatase inhibitors and bipolar mood disorder: a case report. (17042891)
2006
26
Association study of adenosine A2a receptor (1976C>T) genetic polymorphism and mood disorders and age of onset. (16969271)
2006
27
Diagnostic and measurement issues in the assessment of pediatric bipolar disorder: implications for understanding mood disorder across the life cycle. (17064426)
2006
28
Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders. (16191208)
2006
29
Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. (15558078)
2005
30
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
31
Risperidone-induced rabbit syndrome in mood disorder. (15504657)
2004
32
Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders. (15564894)
2004
33
Predicting response to lithium in mood disorders: role of genetic polymorphisms. (12562213)
2003
34
Validity of the mood disorder questionnaire: a general population study. (12505821)
2003
35
Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. (14977467)
2003
36
Review: lithium is effective in preventing relapse in mixed diagnoses of mood disorder and in bipolar disorder. (12026893)
2002
37
Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. (11983185)
2002
38
Clinical relevance of electroconvulsive therapy (ECT) in adolescents with severe mood disorder: evidence from a follow-up study. (12231266)
2002
39
Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. (11576753)
2001
40
Carbamazepine treatment of corticosteroid-induced mood disorder. (11511412)
2001
41
An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia. (11018311)
2000
42
Cognitive factors differentiating attention deficit-hyperactivity disorder with and without a comorbid mood disorder. (9735585)
1998
43
Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients. (9513756)
1998
44
The Kahlbaum syndrome: a study of its clinical validity, nosological status, and relationship with schizophrenia and mood disorder. (8980874)
1997
45
Mood disorder with manic features in a patient treated with granulocyte-monocyte colony stimulating factor. (8849508)
1996
46
Mood disorder and chronic hypercalcemia. (8971664)
1996
47
GABA and mood disorders: a brief review and hypothesis. (8550953)
1995
48
Serotonin responsive and nonresponsive diurnal depressive mood disorders and pathological affect in thalamic infarct associated with myoclonus and blepharospasm. (8018800)
1994
49
Nuclear magnetic resonance spectrometry in mood disorder: a preliminary report. (1912112)
1991
50
Depression and organic mood disorder. (2211553)
1990

Genetic Variations for Mood Disorder

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Expression for genes affiliated with Mood Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mood Disorder

Search GEO for disease gene expression data for Mood Disorder.

Pathways for genes affiliated with Mood Disorder

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Mood Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GABRA1
2
Hide members
11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GALR1
3
Hide members
11.1GNB3, HTR1B, HTR1A, HTR6, DRD4, GALR1
411.0BDNF, GNB3, HTR1A, GABRA1, NTRK2, MAOA
5
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10.9ADRA2A, HTR1B, HTR1A, HTR6, DRD4, MAOA
610.8GNB3, HTR1A, WFS1, NTRK2, NOS1, TPH1
7
Hide members
10.8BDNF, GNB3, HTR1B, HTR1A, HTR6, NTRK2
810.8BDNF, GNB3, CRH, NTRK2, MAOA
9
Hide members
10.7NTRK2, DRD4, GNB3, BDNF
10
Hide members
10.7BDNF, GNB3, CRH, NOS1
1110.7WFS1, HTR1A, GNB3

Compounds for genes affiliated with Mood Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Mood Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2415.0NTRK2, DRD4, HTR6, HTR1A, HTR1B, BDNF
2norepinephrine44 11 2413.7TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
3gaba4411.6TPH1, NOS1, SLC6A4, HCRT, MAOA, NTRK2
4glutamate4411.6NOS1, ADRA2A, BDNF, DRD4, MAOA, CRH
55-hydroxytryptamine4411.5MAOA, CRH, DRD4, HTR6, HTR1A, HTR1B
6fluoxetine49 44 28 1114.5MAOA, TPH1, NOS1, SLC6A4, CRH, HTR1A
7clozapine44 28 49 1114.5HTR1A, BDNF, GNB3, HTR1B, ADRA2A, NOS1
8cocaine44 1112.4SIGMAR1, NOS1, SLC6A4, HCRT, CRH, DRD4
9nmda44 2812.4HTR6, NOS1, HTR1A, DAOA, HCRT, MAOA
10nicotine44 49 28 1114.4NTRK2, TPH1, CRH, DRD4, NOS1, MAOA
11maoa4411.4DRD4, HTR1A, HTR1B, BDNF, MAOA, SLC6A4
12paroxetine44 49 28 1114.3HTR1B, BDNF, TPH1, SLC6A4, MAOA, DRD4
13methamphetamine44 49 1113.3BDNF, DRD4, MAOA, SLC6A4, NOS1, ADRA2A
14epinephrine44 11 2413.3GNB3, BDNF, SLC6A4, HCRT, MAOA, CRH
15risperidone28 44 49 59 11 2416.3HTR1A, BDNF, HTR6, DRD4, SLC6A4, ADRA2A
16olanzapine49 44 28 11 2415.3BDNF, HTR1A, ADRA2A, DRD4, HTR6, GNB3
17catecholamine4411.3HCRT, DRD4, BDNF, ADRA2A, CRH, MAOA
18testosterone44 59 11 2414.3ADRA2A, NOS1, SLC6A4, NTRK2, HCRT, MAOA
19fluvoxamine44 49 1113.3TPH1, SLC6A4, CLOCK, HTR1A, BDNF, MAOA
20amitriptyline44 49 28 1114.3ADRA2A, MAOA, HTR6, NTRK2, SLC6A4, HTR1A
21quetiapine44 49 28 11 2415.3DRD4, HTR6, ADRA2A, HTR1A, BDNF, HTR1B
22mhpg4411.2SLC6A4, DRD4, MAOA, CRH, BDNF
23lithium44 49 11 2414.2BDNF, GNB3, TPH1, NTRK2, SLC6A4, CLOCK
24citalopram49 44 11 2414.2TPH1, MAOA, HTR1A, BDNF, SLC6A4
25methylphenidate44 49 1113.2DRD4, ADRA2A, SLC6A4, HCRT, MAOA
26lisuride28 44 1113.2HTR1B, HTR6, DRD4, ADRA2A, HTR1A
27mianserin28 44 1113.2ADRA2A, SLC6A4, HTR1A, HTR6, MAOA
28levodopa44 1112.2TPH1, MAOA, DRD4, HTR1A, BDNF, HTR1B
29homovanillic acid44 2412.2MAOA, BDNF, CRH, SLC6A4, TPH1
30fenfluramine28 44 1113.2SLC6A4, TPH1, HTR1A, HTR1B, CRH
31corticosterone44 59 2413.1HTR1A, NOS1, SLC6A4, HCRT, CRH, BDNF
32pramipexole44 49 28 1114.1ADRA2A, DRD4, HTR1B, HTR1A, BDNF
33haloperidol44 28 2 49 1115.1BDNF, SIGMAR1, HCRT, DRD4, HTR1A, SLC6A4
34clomipramine44 49 1113.1CRH, HCRT, SLC6A4, MAOA, HTR1A
35asenapine28 1112.1ADRA2A, HTR1B, DRD4, HTR1A, HTR6
36sumatriptan44 28 59 49 11 2416.1MAOA, HTR1A, HTR1B, GNB3, HTR6
37aripiprazole28 49 44 11 2415.1DRD4, HTR1A, HTR1B, ADRA2A, HTR6
38ziprasidone49 28 44 1114.1HTR1B, HTR1A, HTR6, ADRA2A, DRD4
39desipramine44 49 1113.0CRH, HTR1A, BDNF, MAOA, SLC6A4
40bromocriptine28 44 1113.0ADRA2A, HTR1B, DRD4, HTR6, HTR1A
41amoxapine44 28 1113.0ADRA2A, HTR6, GABRA1, SLC6A4
42chlorpromazine44 28 49 1114.0BDNF, HTR1A, HTR6, DRD4, ADRA2A
43mdma4411.0TPH1, SLC6A4, MAOA, HTR1A
44terguride28 4411.9HTR1B, ADRA2A, DRD4, HTR1A
45amphetamine44 1111.9TPH1, DRD4, MAOA, SLC6A4, HCRT
46antidepressants4910.8TPH1, GNB3, BDNF, HTR1A
47imipramine44 49 28 11 2414.8SLC6A4, MAOA, HTR1A, BDNF, NOS1
485-hydroxytryptophan4410.7TPH1, CRH, HTR1A, SLC6A4
49methysergide44 28 1112.6MAOA, HTR1A, HTR1B, HTR6
50choline44 11 2412.6ADRA2A, MAOA, SLC6A4, NOS1, TPH1, BDNF

GO Terms for genes affiliated with Mood Disorder

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16Gene Ontology
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Cellular components related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7ADRA2A, HTR1B, HTR1A, HTR6, DRD4, GABRA1
2dendritic spineGO:04319710.7NOS1, NTRK2, DRD4

Biological processes related to Mood Disorder according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.2HCRT, MAOA, CRH, GABRA1, HTR6, HTR1B
2negative regulation of cAMP biosynthetic processGO:03081811.0HTR1B, DRD4, ADRA2A
3regulation of neurotransmitter secretionGO:04692811.0HCRT, NTRK2, DRD4
4vasoconstrictionGO:04231011.0HTR1B, HTR1A, SLC6A4
5behavioral fear responseGO:00166211.0BDNF, HTR1A, DRD4
6negative regulation of adenylate cyclase activityGO:00719411.0DRD4, GALR1, ADRA2A
7feeding behaviorGO:00763111.0BDNF, CRH, NTRK2
8circadian rhythmGO:00762310.9CLOCK, SLC6A4, TPH1
9adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.9HTR1A, HTR1B
10regulation of serotonin secretionGO:01406210.9CRH, HTR1A
11response to immobilization stressGO:03590210.9TPH1, CRH
12fear responseGO:04259610.9ADRA2A, DRD4
13negative regulation of epinephrine secretionGO:03281110.8ADRA2A, CRH
14mechanoreceptor differentiationGO:04249010.8NTRK2, BDNF
15regulation of dopamine metabolic processGO:04205310.8HTR1A, DRD4
16negative regulation of norepinephrine secretionGO:01070010.7CRH, ADRA2A
17regulation of behaviorGO:05079510.7HTR1B, HTR1A
18negative regulation of potassium ion transportGO:04326710.7HCRT, NOS1
19synaptic transmission, dopaminergicGO:00196310.6DRD4, CRH
20neurotransmitter biosynthetic processGO:04213610.6NOS1, MAOA
21negative regulation of neuron apoptotic processGO:04352410.6BDNF, WFS1, NTRK2
22bone remodelingGO:04684910.3TPH1, HTR1B

Molecular functions related to Mood Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00499310.7HTR6, HTR1A, HTR1B
2drug bindingGO:00814410.4SIGMAR1, GABRA1, DRD4, HTR1B

Products for genes affiliated with Mood Disorder

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  • Antibodies
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Sources for Mood Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet