MCID: MRB003
MIFTS: 52

Morbid Obesity malady

Metabolic diseases category

Summaries for Morbid Obesity

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MalaCards based summary: Morbid Obesity, also known as obesity morbid, is related to obesity and prader-willi syndrome. An important gene associated with Morbid Obesity is LEP (leptin), and among its related pathways are Adipocytokine signaling pathway and Syndecan-3-mediated signaling events. The compounds [125i]shu9119 and pg-901 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and thyroid, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Classifications for Morbid Obesity

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Morbid Obesity, Aliases & Descriptions:

Name: Morbid Obesity 30 9 11
Obesity Morbid 43 22
 
Obesity, Morbid 60
Severe Obesity 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:11981
NCIt38 C34858
MeSH33 D009767
ICD9CM27 278.01

Related Diseases for Morbid Obesity

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Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.5UCP1, ADRB3
2prader-willi syndrome30.9HCRT, LEP, AGRP
3fatty liver disease30.7LEP, ADRB3, FABP2
4obstructive sleep apnea30.6LEP, HCRT
5eating disorder30.4AGRP, MC4R, LEP, HCRT
6polycystic ovary syndrome30.3ADRB3, LEP
7anorexia nervosa30.3HCRT, LEP, MC3R, MC4R, AGRP
8metabolic syndrome x30.0LEP, ADRB3, UCP1
9hyperuricemia29.9ADRB3, FABP2
10atherosclerosis29.7LEP, ADRB3, FABP2, UCP1
11duodenitis10.5
12gastroesophageal reflux10.5
13liver disease10.5
14esophagitis10.5
15hepatitis10.4
16thyroiditis10.4
17obesity, morbid, due to leptin deficiency10.3
18hypogonadism10.3
19gastric outlet obstruction10.3
20bulimia nervosa10.3MC4R, LEP
21morbid obesity and spermatogenic failure10.3
22jejunoileitis10.3
23intussusception10.3
24adenocarcinoma10.3
25elephantiasis10.3
26pancreatitis10.3
27sleep apnea10.3
28endotheliitis10.3
29mody, type ii10.2LEP, ADRB3
30hyperinsulinism10.2MC4R, LEP
31narcolepsy10.2HCRT, LEP
32pulmonary function10.2
33crohn's disease10.2
34wernicke encephalopathy10.2
35portal vein thrombosis10.2
36hypoglycemia10.2
37situs inversus10.2
38gastroparesis10.2
39pseudotumor cerebri10.2
40gastric dilatation10.2
41achalasia10.2
42megaesophagus10.2
43craniopharyngioma10.2
44diverticulitis10.2
45gallbladder disease10.2
46pneumonia10.2
47pseudohypoparathyroidism10.2
48vaginitis10.2
49blindness10.2
50non-suppurative otitis media10.2AGRP, MC4R, LEP

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Symptoms for Morbid Obesity

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Drugs & Therapeutics for Morbid Obesity

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Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Genetic Tests for Morbid Obesity

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Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity22

Anatomical Context for Morbid Obesity

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MalaCards organs/tissues related to Morbid Obesity:

31
Liver, Kidney, Thyroid, Bone, Heart, Testes, Adipocyte, Skin, Monocytes, Endothelial, Colon, Lung, Pancreas, Pituitary, Neutrophil, Brain, Spinal cord, Skeletal muscle, Small intestine, Breast, Ovary, Nk cells

Animal Models for Morbid Obesity or affiliated genes

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MGI Mouse Phenotypes related to Morbid Obesity:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6AGRP, FABP2, MC4R, LEP
2MP:00053888.5NPY1R, ADRA2B, LEP, HCRT
3MP:00053678.1LEP, AQP7, ADRA2B, FABP2
4MP:00053898.0LEP, MC4R, AQP7, ADRA2B, NPY1R, AGRP
5MP:00053857.7HCRT, LEP, MC4R, ADRA2B, UCP1, NPY1R
6MP:00053866.8HCRT, LEP, MC3R, MC4R, ADRB3, ADRA2B
7MP:00053756.7AGRP, LEP, MC3R, MC4R, AQP7, ADRB3
8MP:00053785.7HCRT, LEP, MC3R, MC4R, AQP7, ADRB3
9MP:00053765.6MC4R, MC3R, LEP, HCRT, AQP7, ADRB3

Publications for Morbid Obesity

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Articles related to Morbid Obesity:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Morbid obesity: a significant risk factor for failure of two-stage revision total hip arthroplasty for infection. (25695985)
2015
2
Impact of morbid obesity on the kidney function of patients with type 2 diabetes. (25666105)
2015
3
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. (24990938)
2014
4
An unusual complication of morbid obesity: epidural lipomatosis. (25618765)
2014
5
Impact of Recipient Morbid Obesity on Outcomes After Liver Transplantation. (25363625)
2014
6
Morbid obesity predisposes trauma patients to worse outcomes: A National Trauma Data Bank analysis. (24368375)
2014
7
The Mini-Gastric Bypass in the Management of Morbid Obesity in Prader-Willi Syndrome: A Viable Option? (24063639)
2013
8
Aortic injuries during laparoscopic gastric bypass for morbid obesity in Sweden 2009-2010: a nationwide survey. (24209880)
2013
9
Prolonged benzodiazepine coma as a complication of morbid obesity. (23633162)
2013
10
The role of drainage after Roux-en-Y gastric bypass for morbid obesity: A systematic review. (24355318)
2013
11
Economic evaluation of bariatric surgery to combat morbid obesity: a study from the West of Scotland. (23834746)
2013
12
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report. (23043774)
2012
13
Gastrogastric herniation: an unusual complication following greater curve plication for the treatment of morbid obesity. (22391359)
2012
14
Chylous ascites mimicking peritonitis after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (20947450)
2012
15
Pregnancy following gastric by-pass for morbid obesity. (23025232)
2012
16
Are we prepared for a growing population? Morbid obesity and its implications in Irish emergency departments. (21862929)
2012
17
Gastric plication for morbid obesity: a systematic review. (22960951)
2012
18
SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. (22476829)
2012
19
Roux-en-Y gastric bypass vs gastric banding for morbid obesity: a case-matched study of 442 patients. (22249850)
2012
20
Extreme morbid obesity and labor outcome in nulliparous women at term. (21660900)
2011
21
Evaluation of therapeutic anticoagulation with enoxaparin and associated anti-Xa monitoring in patients with morbid obesity: a case series. (21465129)
2011
22
Transoral gastroplasty for morbid obesity: a multicenter trial with a 1-year outcome. (22136774)
2011
23
Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. (21459682)
2011
24
Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. (20106640)
2011
25
Peripheral polyneuropathy after bariatric surgery for morbid obesity. (22175046)
2011
26
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
27
Treatment of morbid obesity and hiatal paraesophageal hernia by laparoscopic Roux-en-Y gastric bypass. (18773250)
2010
28
Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity. (22053606)
2010
29
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. (20830466)
2010
30
Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. (18463932)
2010
31
Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism. (20226921)
2010
32
Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. (18830789)
2010
33
Influence of weight reduction on leptin concentration and bone mineral density in patients with morbid obesity before and 6 months after bariatric surgery]. (19396752)
2009
34
Morbid obesity in an adolescent with Prader-Willi syndrome. (19543650)
2009
35
Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry. (19572113)
2009
36
G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patients with morbid obesity]. (20049372)
2009
37
Stoma obstruction after laparoscopic adjustable gastric banding for morbid obesity: report of two cases and treatment options. (18721232)
2008
38
Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity. (17431897)
2008
39
Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. (18779208)
2008
40
Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. (16546195)
2007
41
Digestive Adaptation with Intestinal Reserve: a neuroendocrine-based operation for morbid obesity. (17059749)
2006
42
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
43
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. (14964537)
2004
44
Nutritional markers following duodenal switch for morbid obesity. (14980039)
2004
45
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
46
Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. (15114294)
2002
47
Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. (11756707)
2002
48
Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]. (11594118)
2001
49
Association of poorly controlled diabetes with low serum leptin in morbid obesity. (9226485)
1997
50
Atrophic beriberi. A complication of jejunoileal bypass surgery for morbid obesity. (210663)
1978

Variations for Morbid Obesity

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Expression for genes affiliated with Morbid Obesity

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Search GEO for disease gene expression data for Morbid Obesity.

Pathways for genes affiliated with Morbid Obesity

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Compounds for genes affiliated with Morbid Obesity

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Compounds related to Morbid Obesity according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1[125i]shu91192810.2MC4R, MC3R
2pg-9012810.2MC3R, MC4R
3agouti-related protein2810.2MC3R, MC4R
4hs0142810.2MC3R, MC4R
5hs0242810.2MC3R, MC4R
6shu91192810.2MC3R, MC4R
7mt-ii2810.2MC3R, MC4R
8[125i]ndp-msh2810.2MC3R, MC4R
9ndp-msh2810.2MC4R, MC3R
10[d-trp8]-gamma-msh5910.1MC3R, MC4R
11clenbuterol43 1211.1LEP, ADRB3
12alpha-msh59 2811.1MC3R, MC4R
13hs 0145910.1MC3R, MC4R
14pg 1065910.1MC3R, MC4R
15(plusmn)-adrenaline2810.0ADRA2B, ADRB3
16stavudine43 1211.0UCP1, LEP
17shu 911959 4311.0LEP, MC3R, MC4R
18(-)-noradrenaline289.9ADRB3, ADRA2B
19enterostatin439.9LEP, HCRT
20rimonabant43 28 1211.9HCRT, LEP
21thiazolidinedione439.8LEP, UCP1
22oxyntomodulin43 5910.7HCRT, LEP, AGRP
23amphetamine43 49 1211.6HCRT, MC4R, AGRP
24alpha msh439.6LEP, MC3R, MC4R, AGRP
25quetiapine43 49 28 24 1213.6LEP, ADRA2B
26gnrh439.5HCRT, LEP, MC3R
27phenylephrine43 28 24 1212.5ADRA2B, LEP, HCRT
28catecholamine439.5UCP1, ADRB3, HCRT
29corticosterone43 59 2411.4HCRT, LEP, MC3R, MC4R
30olanzapine43 49 28 24 1213.4ADRA2B, ADRB3, MC4R, LEP
31clozapine43 28 49 1212.4LEP, MC4R, ADRB3, ADRA2B
32thyroxine43 2410.4UCP1, LEP, HCRT
33c-peptide439.3HCRT, LEP, ADRB3, UCP1
34epinephrine43 24 1211.2ADRA2B, ADRB3, LEP, HCRT
35carboxylate439.2UCP1, FABP2
36palmitate439.1UCP1, FABP2, MC4R
37cocaine43 1210.1HCRT, LEP, MC3R, MC4R, AGRP
38acth439.1AGRP, MC4R, MC3R, LEP, HCRT
39cyclic amp43 2410.1HCRT, MC3R, ADRB3, UCP1
40glutamate438.8UCP1, ADRA2B, LEP, HCRT
41norepinephrine43 24 1210.8HCRT, LEP, ADRB3, ADRA2B, UCP1
42cysteine438.6AGRP, UCP1, FABP2, LEP
43nitric oxide43 24 1210.5HCRT, MC4R, ADRB3, UCP1, NPY1R
44atp43 289.5HCRT, ADRB3, UCP1, NPY1R, AGRP
45estrogen438.4NPY1R, ADRB3, LEP, HCRT
46alanine438.3HCRT, MC4R, ADRB3, FABP2, UCP1
47fatty acid438.3AGRP, UCP1, FABP2, ADRB3, MC4R, LEP
48lipid437.8HCRT, LEP, MC3R, MC4R, ADRB3, FABP2
49cholesterol43 28 24 1210.6HCRT, LEP, MC4R, ADRB3, ADRA2B, FABP2
50glucose437.0AGRP, HCRT, LEP, MC3R, MC4R, ADRB3

GO Terms for genes affiliated with Morbid Obesity

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Cellular components related to Morbid Obesity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.0MC3R, AQP7, ADRB3, ADRA2B, NPY1R
2plasma membraneGO:00058867.9MC3R, MC4R, AQP7, ADRB3, ADRA2B, NPY1R

Biological processes related to Morbid Obesity according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:000834310.0AGRP, LEP
2diet induced thermogenesisGO:000202410.0ADRB3, MC4R
3insulin secretionGO:00300739.9MC4R, LEP
4positive regulation of cAMP biosynthetic processGO:00308199.9MC3R, MC4R
5brown fat cell differentiationGO:00508739.8ADRB3, UCP1
6adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00071889.8ADRB3, MC4R, MC3R
7response to insulinGO:00328689.7AGRP, MC4R, LEP
8energy reserve metabolic processGO:00061129.7LEP, MC4R, ADRB3
9female pregnancyGO:00075659.7ADRA2B, LEP
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.7MC3R, HCRT
11generation of precursor metabolites and energyGO:00060919.6ADRB3, AQP7
12positive regulation of MAPK cascadeGO:00434109.6ADRB3, LEP
13regulation of blood pressureGO:00082179.5LEP, MC3R, NPY1R
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.5MC3R, ADRB3, NPY1R
15feeding behaviorGO:00076319.4MC4R, NPY1R, AGRP
16eating behaviorGO:00427559.3AGRP, ADRB3, LEP, HCRT
17neuropeptide signaling pathwayGO:00072189.2HCRT, NPY1R, AGRP

Molecular functions related to Morbid Obesity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1melanocyte-stimulating hormone receptor activityGO:00049809.9MC4R, MC3R
2peptide hormone bindingGO:00170469.8MC4R, MC3R
3melanocortin receptor activityGO:00049779.7MC3R, MC4R
4epinephrine bindingGO:00513799.6ADRB3, ADRA2B
5neuropeptide bindingGO:00429239.5MC4R, MC3R

Products for genes affiliated with Morbid Obesity

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Sources for Morbid Obesity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet