MCID: MRB003
MIFTS: 60

Morbid Obesity malady

Metabolic category

Summaries for Morbid Obesity

Sources:
47OMIM, 33MalaCards
See all sources

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MalaCards: Morbid Obesity, also known as obesity, severe, is related to insulin resistance and fatty liver disease. An important gene associated with Morbid Obesity is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and PPAR signaling pathway. The compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Description from OMIM:47 601665

Aliases & Classifications for Morbid Obesity

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 47OMIM, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

morbid obesity 8 22 10
obesity, severe 47
obesity, morbid 61
severe obesity 8
obesity morbid 45


External Ids:

Disease Ontology8 DOID:11981
ICD9CM27 278.01
NCIt40 C34858
MeSH35 D009767

Related Diseases for Morbid Obesity

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.0UCP1, UCP2, PYY, ADRB3, PLIN1, LEP
2fatty liver disease30.6UCP2, FABP2, PPARG, LEP, ADRB3
3anorexia nervosa30.4LEP, MC3R, MC4R, AGRP, PYY
4adenocarcinoma30.3PYY, CCKAR, UCP2
5atherosclerosis30.0UCP2, UCP1, UCP3, FABP2, FABP4, PPARG
6polycystic ovary syndrome30.0PPARG, LIPE, NAMPT, LEP, ADRB3
7hyperuricemia29.8ADRB3, FABP2
8growth hormone deficiency29.8LEP
9prader-willi syndrome10.5
10gastroesophageal reflux disease10.4
11obesity, early-onset10.4
12gastric ulcer10.3
13gastric outlet obstruction10.3
14wernicke encephalopathy10.2
15intussusception10.2
16sleep apnea10.2
17bone fracture10.2
18megaesophagus10.2
19gastric dilatation10.2
20portal vein thrombosis10.2
21hypoglycemia10.2
22situs inversus10.2
23gastroparesis10.2
24thromboembolism10.2
25obesity, variation in10.2
26pulmonary function10.2
27venous thromboembolism10.2
28alexithymia10.1
29obesity, severe, and type ii diabetes10.1
30obesity, severe bmiq910.1
31attention deficit hyperactivity disorder10.0
32fecal incontinence10.0
33parkinson's disease10.0
34crohn's disease10.0
35wagr syndrome10.0
36pseudotumor cerebri10.0
37acanthosis nigricans10.0
38primary hyperparathyroidism10.0
39achalasia10.0
40superior mesenteric artery syndrome10.0
41immune-complex glomerulonephritis10.0
42linitis plastica10.0
43actinomycosis10.0
44gastrojejunal ulcer10.0
45post-traumatic stress disorder10.0
46infertility10.0
47hyperinsulinemic hypoglycemia10.0
48n syndrome10.0
49mumps10.0
50beriberi10.0

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Clinical Features for Morbid Obesity

Sources:
47OMIM
See all sources

Clinical features from OMIM:

601665

Drugs & Therapeutics for Morbid Obesity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Morbid Obesity

Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Search CenterWatch for Morbid Obesity

Genetic Tests for Morbid Obesity

Sources:
22GTR
See all sources

Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity22

Anatomical Context for Morbid Obesity

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Morbid Obesity:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lung, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Monocytes, Nk cells, T cells, Endothelial, Pancreatic islet, Pituitary

Animal Models for Morbid Obesity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Morbid Obesity

Sources:
51PubMed
See all sources

Articles related to Morbid Obesity:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
A review of the nutritional value of legumes and their effects on obesity and its related co-morbidities. (24433379)
2014
2
The role of drainage after Roux-en-Y gastric bypass for morbid obesity: A systematic review. (24355318)
2013
3
Does morbid obesity worsen outcomes after esophagectomy? (23434257)
2013
4
Particular characteristics of the metabolic syndrome in patients with morbid obesity. (23266153)
2013
5
Morbid obesity may increase dislocation in total hip patients: a biomechanical analysis. (22907474)
2013
6
A 47,X,+t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2),Y Klinefelter variant with morbid obesity. (23364994)
2013
7
Roux-en-Y gastric bypass for morbid obesity: what are the preoperative predictors of weight loss? (23472004)
2013
8
Laparoscopic Roux-en-Y gastric bypass vs. laparoscopic sleeve gastrectomy for morbid obesity and diabetes mellitus: a meta-analysis of sixteen recent studies. (22944342)
2013
9
Relationship between urban sprawl and physical activity, obesity, and morbidity - Update and refinement. (24434082)
2013
10
Developing comprehensive and Brief ICF core sets for morbid obesity for disability assessment in Taiwan: a preliminary study. (23820878)
2013
11
Gastrogastric herniation: an unusual complication following greater curve plication for the treatment of morbid obesity. (22391359)
2012
12
Letter to "Functional importance of laparoscopic sleeve gastrectomy for the lower esophageal sphincter in patients with morbid obesity" OBES SURG (2012) 22:360-366 DOI 10.1007/s11695-011-0536-5. (22790711)
2012
13
Morbid obesity is associated with increased resource utilization in coronary artery bypass grafting. (22607785)
2012
14
The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity. (22828946)
2012
15
Functional importance of laparoscopic sleeve gastrectomy for the lower esophageal sphincter in patients with morbid obesity. (22467053)
2012
16
Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment induced by morbid obesity. (20803097)
2011
17
Laparoscopic resectional gastric bypass in patients with morbid obesity: experience on 112 consecutive patients. (21061177)
2011
18
Constipation and colonic transit times in children with morbid obesity. (21240026)
2011
19
A 5-year prospective quality of life analysis following laparoscopic adjustable gastric banding for morbid obesity. (21553303)
2011
20
Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss. (21394384)
2011
21
Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism. (20226921)
2010
22
Morbid obesity is associated with fear of movement and lower quality of life in patients with knee pain-related diagnoses. (20709300)
2010
23
Morbid obesity in pediatric diabetes mellitus: surgical options and outcomes. (20842181)
2010
24
Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery. (20877950)
2010
25
Post-traumatic stress disorder (PTSD) is not a contraindication to gastric bypass in veterans with morbid obesity. (20063014)
2010
26
Comprehensive interview assessment of eating behavior 18-35 months after gastric bypass surgery for morbid obesity. (19837012)
2010
27
Does body mass index/morbid obesity influence outcome in patients who undergo pancreatoduodenectomy for pancreatic adenocarcinoma? (20676790)
2010
28
Laparoscopic conversion of sleeve gastrectomy to Roux-en-Y gastric bypass for acute gastric outlet obstruction after laparoscopic sleeve gastrectomy for morbid obesity. (20678971)
2010
29
Reasons and outcomes of laparoscopic revisional surgery after laparoscopic adjustable gastric banding for morbid obesity. (20655021)
2010
30
Prospective study of health-related quality of life after Roux-en-Y bypass surgery for morbid obesity. (20645295)
2010
31
A prospective randomized study comparing patients with morbid obesity submitted to laparotomic gastric bypass with or without omentectomy. (18712575)
2009
32
Gastroesophageal reflux disease and morbid obesity: is there a relation? (19404705)
2009
33
RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity. (19367438)
2009
34
Safety and short-term outcomes of laparoscopic sleeve gastrectomy as a revisional approach for failed laparoscopic adjustable gastric banding in the treatment of morbid obesity. (19711138)
2009
35
Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. (19464069)
2009
36
Severe psoriasis, morbid obesity and bariatric surgery. (19747301)
2009
37
Incidence and management of enteric leaks after gastric bypass for morbid obesity during a 10-year period. (18407803)
2008
38
Gastroesophageal reflux in patients with morbid obesity: a role of obstructive sleep apnea syndrome? (18418659)
2008
39
Evolution of the blood parameters after morbid obesity surgery with the duodenal crossing technique]. (19160895)
2008
40
Limitations of a standardized weight-based nomogram for heparin dosing in patients with morbid obesity. (18586569)
2008
41
Does preoperative weight loss predict success following surgery for morbid obesity? (18424277)
2008
42
Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulin. (18713823)
2008
43
Chronic lymphedema due to morbid obesity: an exceptional cause of abdominal wall angiosarcoma. (18560886)
2008
44
Chronic immune activation underlies morbid obesity: is IDO a key player? (17430117)
2007
45
Increased gastric cytokine production after Roux-en-Y gastric bypass for morbid obesity. (17938310)
2007
46
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
47
Nutritional markers following duodenal switch for morbid obesity. (14980039)
2004
48
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
49
Markers for the gene ob and serum leptin levels in human morbid obesity. (9150718)
1997
50
Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity. (9416435)
1997

Genetic Variations for Morbid Obesity

Expression for genes affiliated with Morbid Obesity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Morbid Obesity

Search GEO for disease gene expression data for Morbid Obesity.

Pathways for genes affiliated with Morbid Obesity

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8ADRB3, LEP, MC3R, MC4R, CCKAR, PYY
210.8AQP7, PLIN1, PPARG, FABP4, FABP2, UCP1
310.7PPARG, LIPE, NAMPT, LEP, PLIN1
4
Hide members
10.7ADRB3, PLIN1, LIPE, PPARG, UCP1
5
Hide members
10.7UCP2, UCP1, UCP3, PPARG, LEP
610.7PLIN1, LEP, PPARG, FABP4
710.7FABP4, PPARG, LIPE, PLIN1
810.6AGRP, MC4R, MC3R
9
Hide members
10.6MC3R, MC4R, CCKAR
1010.6PPARG, UCP3, UCP2
1110.6FABP4, LIPE, PLIN1
12
Hide members
10.6FABP4, LIPE, PLIN1
13
Hide members
10.6UCP2, UCP1, UCP3
1410.6MC4R, AGRP

Compounds for genes affiliated with Morbid Obesity

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Morbid Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1glucose4511.7PYY, CCKAR, UCP2, UCP1, UCP3, ISL1
2lipid4511.6FABP4, PPARG, LIPE, MC4R, MC3R, NAMPT
3fatty acid4511.6AGRP, PPARG, FABP4, FABP2, UCP3, UCP1
4cholesterol45 29 11 2414.6PYY, CCKAR, UCP2, UCP1, UCP3, FABP2
5rosiglitazone45 50 29 11 2415.3FABP4, PPARG, UCP2, UCP1, LEP, NAMPT
6norepinephrine45 11 2413.3UCP2, UCP1, UCP3, ADRB3, LIPE, LEP
7oleic acid45 29 11 2414.2LIPE, FABP2, UCP2, CCKAR, PYY, FABP4
8thiazolidinedione4511.2UCP3, UCP2, UCP1, PPARG, LEP, FABP4
9cocaine45 1112.2CCKAR, PYY, MC4R, MC3R, LEP, AGRP
10palmitate4511.2FABP4, MC4R, FABP2, UCP1, UCP2, UCP3
11cyclic amp45 2412.2MC3R, PLIN1, LIPE, UCP1, ADRB3, CCKAR
12glycerol45 11 2413.2AQP7, PLIN1, LEP, LIPE, PPARG, FABP4
13pyruvate4511.2LIPE, UCP2, FABP4, FABP2, UCP3, UCP1
14glycerol 3-phosphate45 2412.1PLIN1, FABP4, PPARG, LIPE, LEP
152-deoxyglucose45 1112.1UCP3, AGRP, LIPE, PPARG, PYY
16triacylglycerol4511.1FABP2, PLIN1, LIPE, LEP, PYY
17carnitine4511.1PPARG, UCP2, UCP3, LIPE, UCP1
18catecholamine4511.1ADRB3, PLIN1, LIPE, UCP1, UCP2
19alpha msh4511.1AGRP, LEP, MC3R, MC4R
20acyl-coa4511.1UCP2, UCP3, FABP4, LIPE, PLIN1
21p0034511.1UCP2, PYY, UCP1, UCP3, LEP
22troglitazone45 29 60 1114.1PPARG, UCP2, FABP4, LEP, UCP3
23intralipid4511.1UCP3, CCKAR, PYY, LEP
24carbohydrates4511.1PYY, LEP, CCKAR, UCP2, FABP2
25isoproterenol45 1112.1PYY, UCP2, PLIN1, ADRB3, LIPE
26acth4511.1PYY, LEP, MC3R, MC4R, AGRP
27alanine4511.1FABP2, CCKAR, ADRB3, UCP2, PPARG, MC4R
28bezafibrate45 29 1113.0UCP2, UCP3, PPARG, UCP1
29fenofibrate45 50 1113.0LEP, UCP2, FABP2, PPARG
30shu 911945 6012.0MC4R, LEP, MC3R
31c-peptide4511.0LEP, PYY, ADRB3, UCP1
32pioglitazone45 50 29 1114.0LEP, FABP4, PPARG, NAMPT
33stearic acid45 11 2413.0PPARG, FABP4, FABP2, LIPE
34stavudine45 1112.0UCP1, LEP, PPARG
35ribonucleic acid4511.0UCP3, LIPE, NAMPT, UCP2, UCP1
36triiodothyronine4511.0UCP2, UCP1, UCP3, LEP
37palmitic acid29 11 2412.9LIPE, PPARG, FABP4, FABP2
38carbacyclin45 2911.9PPARG, UCP2, UCP3
39acipimox45 2911.9LIPE, LEP, UCP3
40oxyntomodulin45 6011.9AGRP, PYY, LEP
41linoleic acid45 29 2412.9PPARG, FABP2, UCP2, UCP1
42orlistat45 60 1112.8PYY, PPARG, LEP
43[125i]shu91192910.8MC4R, MC3R
44agouti-related protein2910.7MC4R, MC3R
45pg-9012910.7MC4R, MC3R
46hs0142910.6MC4R, MC3R
47niacin45 1111.6PPARG, NAMPT, LIPE
48carboxylate4510.6FABP2, FABP4, UCP1
49glycogen45 2411.6FABP2, UCP2, ADRB3, LIPE, UCP3
50thyroxine45 2411.4LEP, PPARG, UCP1, UCP2

GO Terms for genes affiliated with Morbid Obesity

Sources:
16Gene Ontology
See all sources

Cellular components related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid particleGO:00581110.6PLIN1, LIPE, FABP4

Biological processes related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:05087311.0ADRB3, PPARG, FABP4, UCP1
2feeding behaviorGO:00763111.0MC4R, AGRP, CCKAR, PYY
3small molecule metabolic processGO:04428111.0UCP2, UCP1, UCP3, FABP4, LIPE, NAMPT
4mitochondrial transportGO:00683911.0UCP2, UCP1, UCP3
5eating behaviorGO:04275511.0ADRB3, LEP, PYY
6triglyceride catabolic processGO:01943311.0PLIN1, LIPE, FABP4
7proton transportGO:01599210.9UCP2, UCP1, UCP3
8response to coldGO:00940910.9ADRB3, PPARG, UCP3
9adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.9ADRB3, MC3R, MC4R
10response to insulin stimulusGO:03286810.9UCP3, MC4R, LEP
11regulation of blood pressureGO:00821710.9PPARG, MC3R, LEP
12digestionGO:00758610.9FABP2, CCKAR, PYY
13response to superoxideGO:00030310.8UCP3, UCP2
14response to nutrientGO:00758410.8PPARG, UCP3, CCKAR
15diet induced thermogenesisGO:00202410.8ADRB3, MC4R
16adult feeding behaviorGO:00834310.8LEP, AGRP
17respiratory electron transport chainGO:02290410.7UCP2, UCP1, UCP3
18white fat cell differentiationGO:05087210.7FABP4, PPARG
19energy reserve metabolic processGO:00611210.7ADRB3, LEP, MC4R
20cellular metabolic processGO:04423710.6UCP3, UCP1, UCP2
21cellular response to lithium ionGO:07128510.6PPARG, FABP4
22lipid metabolic processGO:00662910.5UCP3, PPARG, PLIN1
23adipose tissue developmentGO:06061210.3LEP, NAMPT

Molecular functions related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.6UCP3, UCP1
2melanocyte-stimulating hormone receptor activityGO:00498010.6MC3R, MC4R
3fatty acid bindingGO:00550410.6FABP4, FABP2
4melanocortin receptor activityGO:00497710.5MC4R, MC3R
5neuropeptide bindingGO:04292310.3MC3R, MC4R

Products for genes affiliated with Morbid Obesity

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Sources for Morbid Obesity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet