MCID: MRB003
MIFTS: 67

Morbid Obesity malady

Genetic diseases (common), Metabolic diseases categories

Summaries for Morbid Obesity

About this section


MalaCards based summary: Morbid Obesity, also known as obesity, severe, is related to obesity and prader-willi syndrome. An important gene associated with Morbid Obesity is SIM1 (single-minded family bHLH transcription factor 1), and among its related pathways are Syndecan-3-mediated signaling events and The fatty acid cycling model. The compounds ici 118551 and carazolol have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are liver/biliary system and normal.

Description from OMIM:46 601665

Aliases & Classifications for Morbid Obesity

About this section

Morbid Obesity, Aliases & Descriptions:

Name: Morbid Obesity 31 9 23 11
Obesity, Severe 46
Obesity, Morbid 61
 
Severe Obesity 9
Obesity Morbid 44


Classifications:



External Ids:

Disease Ontology9 DOID:11981
ICD9CM28 278.01
MeSH34 D009767
NCIt39 C34858

Related Diseases for Morbid Obesity

About this section

Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.4MC4R, UCP3, PPARG
2prader-willi syndrome31.3PYY, HCRT, LEP, AGRP
3fatty liver disease31.0FABP2, ADRB3, LEP, PPARG
4eating disorder30.9MC4R, LEP, PYY, AGRP, HCRT
5hypertension30.8PPARG, ADRB2, LEP, ADRB3
6anorexia nervosa30.8AGRP, LEP, MC4R, PYY, HCRT, MC3R
7obstructive sleep apnea30.7HCRT, LEP
8constipation30.6PYY
9polycystic ovary syndrome30.4ADRB3, LEP, PPARG
10metabolic syndrome x30.3LEP, PPARG
11diabetes mellitus30.2MC4R, PYY, PPARG, ADRB3, FABP2, UCP3
12hyperuricemia30.2ADRB3, FABP2
13insulin resistance30.2PPARG, ADRB3, ADRB2, UCP1, UCP3, FABP2
14hyperglycemia30.0ENPP1, LEP, PPARG, PYY, ADRB3
15type 2 diabetes mellitus29.8ENPP1, UCP1, UCP3, FABP2, ADRB2, ADRB3
16atherosclerosis29.6ENPP1, UCP3, ADRB3, ADRB2, FABP2, LEP
17duodenitis10.5
18liver disease10.5
19esophagitis10.5
20double outlet right ventricle10.4PYY, LEP, MC4R
21non-suppurative otitis media10.4AGRP, MC4R, LEP
22gastroesophageal reflux disease10.4
23bulimia nervosa10.4LEP, PYY, MC4R
24hepatitis10.4
25essential hypertension10.4LEP, ADRB2, ADRA2B, ADRB3
26familial combined hyperlipidemia10.3ADRB3, FABP2
27hypogonadism10.3
28thyroiditis10.3
29gastric outlet obstruction10.3
30gestational diabetes10.3ADRB3, ENPP1, LEP
31familial partial lipodystrophy10.3LEP, PPARG
32hyperinsulinism10.3PPARG, MC4R, LEP
33congenital generalized lipodystrophy type 210.3PPARG, LEP
34hyperandrogenism10.3PPARG, LEP, MC4R
35narcolepsy10.3HCRT, LEP
36pre-eclampsia10.3LEP, ADRB2, ADRB3
37jejunoileitis10.3
38intussusception10.3
39adenocarcinoma10.3
40elephantiasis10.3
41pancreatitis10.3
42endotheliitis10.3
43hypertriglyceridemia10.2FABP2, ADRB3, PPARG, LEP
44pheochromocytoma10.2ADRB2, HCRT, UCP1, PYY
45type 1 diabetes mellitus10.2LEP, ADRB3, ADRB2, UCP1, ENPP1
46crohn's disease10.2
47wernicke encephalopathy10.2
48situs inversus10.2
49megaesophagus10.2
50portal vein thrombosis10.2

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Symptoms for Morbid Obesity

About this section


Clinical features from OMIM:

601665

Drugs & Therapeutics for Morbid Obesity

About this section

Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Genetic Tests for Morbid Obesity

About this section

Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity23

Anatomical Context for Morbid Obesity

About this section

MalaCards organs/tissues related to Morbid Obesity:

32
Liver, Kidney, Bone, Thyroid, Heart, Adipocyte, Monocytes, Endothelial, Colon, Lung, Pancreas, Skin, Testes, Pituitary, Neutrophil, Brain, Spinal cord, Skeletal muscle, Small intestine, Breast, Ovary, Nk cells

Animal Models for Morbid Obesity or affiliated genes

About this section

Publications for Morbid Obesity

About this section

Articles related to Morbid Obesity:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. (24990938)
2014
2
Impact of Recipient Morbid Obesity on Outcomes After Liver Transplantation. (25363625)
2014
3
Morbid obesity predisposes trauma patients to worse outcomes: A National Trauma Data Bank analysis. (24368375)
2014
4
The Mini-Gastric Bypass in the Management of Morbid Obesity in Prader-Willi Syndrome: A Viable Option? (24063639)
2013
5
Aortic injuries during laparoscopic gastric bypass for morbid obesity in Sweden 2009-2010: a nationwide survey. (24209880)
2013
6
Prolonged benzodiazepine coma as a complication of morbid obesity. (23633162)
2013
7
The role of drainage after Roux-en-Y gastric bypass for morbid obesity: A systematic review. (24355318)
2013
8
Economic evaluation of bariatric surgery to combat morbid obesity: a study from the West of Scotland. (23834746)
2013
9
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report. (23043774)
2012
10
Gastrogastric herniation: an unusual complication following greater curve plication for the treatment of morbid obesity. (22391359)
2012
11
Chylous ascites mimicking peritonitis after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (20947450)
2012
12
Pregnancy following gastric by-pass for morbid obesity. (23025232)
2012
13
Are we prepared for a growing population? Morbid obesity and its implications in Irish emergency departments. (21862929)
2012
14
Gastric plication for morbid obesity: a systematic review. (22960951)
2012
15
SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. (22476829)
2012
16
Roux-en-Y gastric bypass vs gastric banding for morbid obesity: a case-matched study of 442 patients. (22249850)
2012
17
Assessment of radiofrequency device sensitivity for the detection of retained surgical sponges in patients with morbid obesity. (23070411)
2012
18
Extreme morbid obesity and labor outcome in nulliparous women at term. (21660900)
2011
19
Evaluation of therapeutic anticoagulation with enoxaparin and associated anti-Xa monitoring in patients with morbid obesity: a case series. (21465129)
2011
20
Transoral gastroplasty for morbid obesity: a multicenter trial with a 1-year outcome. (22136774)
2011
21
Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. (21459682)
2011
22
Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. (20106640)
2011
23
Peripheral polyneuropathy after bariatric surgery for morbid obesity. (22175046)
2011
24
Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda. (21479752)
2011
25
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
26
Treatment of morbid obesity and hiatal paraesophageal hernia by laparoscopic Roux-en-Y gastric bypass. (18773250)
2010
27
Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity. (22053606)
2010
28
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. (20830466)
2010
29
Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. (18463932)
2010
30
Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism. (20226921)
2010
31
Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. (18830789)
2010
32
T-tube gastrostomy as a novel approach for distal staple line disruption after sleeve gastrectomy for morbid obesity: case report and review of the literature. (19575273)
2010
33
Influence of weight reduction on leptin concentration and bone mineral density in patients with morbid obesity before and 6 months after bariatric surgery]. (19396752)
2009
34
Morbid obesity in an adolescent with Prader-Willi syndrome. (19543650)
2009
35
Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry. (19572113)
2009
36
G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patients with morbid obesity]. (20049372)
2009
37
Stoma obstruction after laparoscopic adjustable gastric banding for morbid obesity: report of two cases and treatment options. (18721232)
2008
38
Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity. (17431897)
2008
39
Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. (18779208)
2008
40
Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. (16546195)
2007
41
Digestive Adaptation with Intestinal Reserve: a neuroendocrine-based operation for morbid obesity. (17059749)
2006
42
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
43
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. (14964537)
2004
44
Nutritional markers following duodenal switch for morbid obesity. (14980039)
2004
45
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
46
Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. (15114294)
2002
47
Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. (11756707)
2002
48
Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]. (11594118)
2001
49
Association of poorly controlled diabetes with low serum leptin in morbid obesity. (9226485)
1997
50
Atrophic beriberi. A complication of jejunoileal bypass surgery for morbid obesity. (210663)
1978

Variations for Morbid Obesity

About this section

UniProtKB/Swiss-Prot genetic disease variations for Morbid Obesity:

63 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Morbid Obesity:

7 (show all 39)
id Gene Name Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
30MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
31MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
32MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
33MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
34NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
35NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
36MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
37CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
38PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
39MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Morbid Obesity

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Morbid Obesity patients vs. healthy controls: 31 (show all 9)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1GAPDHglyceraldehyde-3-phosphate dehydrogenaseSkeletal Muscle-5.090.006
2SLNsarcolipinSkeletal Muscle-4.640.007
3RPL41ribosomal protein L41Skeletal Muscle-2.890.036
4TNNC2troponin C type 2 (fast)Skeletal Muscle-2.710.022
5RHODras homolog family member DSkeletal Muscle-2.010.013
6IL17Ainterleukin 17ASkeletal Muscle+1.950.012
7CCDC40coiled-coil domain containing 40Skeletal Muscle-1.910.045
8CD44CD44 molecule (Indian blood group)Skeletal Muscle-1.770.036
9GRB14growth factor receptor-bound protein 14Skeletal Muscle+1.390.036

Expression patterns in normal tissues for genes affiliated with Morbid Obesity

Search GEO for disease gene expression data for Morbid Obesity.

Pathways for genes affiliated with Morbid Obesity

About this section

Pathways related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2AGRP, MC4R
2
Show member pathways
10.2UCP3, UCP1
3
Show member pathways
10.0ADRB3, ADRA2B, ADRB2
410.0MC4R, MC3R, AGRP
510.0UCP1, PPARG, LEP
69.9MC4R, ADRB3, MC3R, ADRB2
7
Show member pathways
9.9UCP1, ADRB2, ADRB3, PPARG
89.8ADRB2, NPY1R, ADRA2B, PYY
9
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.8FABP2, PPARG, AQP7, UCP1
10
Show member pathways
Peptide GPCRs37
9.8HCRT, MC4R, MC3R, NPY1R
11
Show member pathways
9.7UCP1, LEP, PPARG, UCP3, MT-CYB
12
Show member pathways
9.0ADRA2B, ADRB3, MC3R, LEP, ADRB2, PYY
13
Show member pathways
9.0ADRA2B, MC3R, HCRT, PYY, ADRB3, LEP

Compounds for genes affiliated with Morbid Obesity

About this section

Compounds related to Morbid Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1ici 1185512910.5ADRB3, ADRB2
2carazolol44 2911.5ADRB2, ADRB3
3[125i]shu91192910.5MC4R, MC3R
4clenbuterol44 1211.4ADRB3, ADRB2, LEP
5shu 911960 4411.4LEP, MC3R, MC4R
6intralipid4410.4LEP, UCP3, PYY
7orlistat44 60 1212.4PYY, PPARG, LEP
8stavudine44 1211.4UCP1, PPARG, LEP
9pg-9012910.4MC4R, MC3R
10hs0142910.3MC4R, MC3R
112-deoxyglucose44 1211.3AGRP, UCP3, PYY, PPARG
12agouti-related protein2910.3MC4R, MC3R
13salbutamol44 50 29 25 1214.3ADRB3, UCP3, ADRB2
14thiazolidinedione4410.3UCP3, LEP, UCP1, PPARG
15alpha msh4410.3LEP, MC4R, AGRP, MC3R
16isoprenaline2910.3ADRB3, ADRB2
17olanzapine44 50 29 25 1214.3ADRB3, ADRA2B, LEP, MC4R
18[125i]icyp2910.2ADRB2, ADRB3
19oxyntomodulin44 6011.2LEP, PYY, AGRP, HCRT
20rosiglitazone29 44 50 25 1214.2UCP3, PPARG, LEP, UCP1
21p0034410.2UCP3, PYY, UCP1, LEP
22clozapine44 29 50 1213.2ADRB2, MC4R, ADRA2B, ADRB3, LEP
23corticosterone44 60 2512.2HCRT, MC3R, LEP, MC4R
24catecholamine4410.1HCRT, UCP1, ADRB2, ADRB3
25palmitate4410.1UCP3, UCP1, FABP2, MC4R, PPARG
26cgp 1217729 4411.1ADRB2, ADRB3
27amphetamine44 50 1212.1AGRP, MC4R, PYY, HCRT, CARTPT
28c-peptide4410.1LEP, PYY, HCRT, ADRB3, UCP1
29bezafibrate44 29 1212.1UCP3, UCP1, PPARG
30thyroxine44 2511.0LEP, HCRT, PPARG, UCP1
31gnrh4410.0HCRT, LEP, ADRB2, PYY, MC3R
32epinephrine44 25 1212.0ADRB2, ADRA2B, ADRB3, LEP, HCRT
33gtp44 2911.0PYY, ADRB2, UCP1, UCP3, MT-CYB
34dopamine44 29 25 1212.9MC3R, CARTPT, ADRB2, PYY, HCRT, MC4R
35acth449.9AGRP, MC4R, MC3R, PYY, HCRT, LEP
36hydrogen44 2510.9MT-CYB, FABP2, ADRB2, UCP1, PYY, UCP3
37sr59230a299.9ADRB2, ADRB3
38dexamethasone44 50 29 1212.8ADRB2, PPARG, HCRT, LEP, ADRB3, ENPP1
39cocaine44 1210.7MC4R, MC3R, ADRB2, CARTPT, AGRP, LEP
40cyclic amp44 2510.7PYY, HCRT, MC3R, ADRB3, ADRB2, CARTPT
41estrogen449.7ADRB3, PPARG, LEP, NPY1R, PYY, HCRT
42norepinephrine44 25 1211.6HCRT, ADRB3, PYY, LEP, ADRA2B, ADRB2
43nitric oxide44 25 1211.6MC4R, MT-CYB, NPY1R, UCP1, UCP3, ADRB2
44alanine449.6UCP1, MT-CYB, ADRB2, ADRB3, MC4R, HCRT
45atp44 2910.4NPY1R, AGRP, HCRT, ADRB3, UCP1, UCP3
46fatty acid449.4PPARG, PYY, LEP, ENPP1, UCP1, AGRP
47calcium44 50 25 1212.3HCRT, ENPP1, NPY1R, PYY, MC3R, MC4R
48cholesterol44 29 25 1212.3ADRB3, MC4R, FABP2, ADRA2B, UCP3, UCP1
49lipid448.9ADRB2, ADRB3, MC4R, MC3R, HCRT, PYY
50glucose448.6UCP1, AGRP, ENPP1, PPARG, UCP3, MT-CYB

GO Terms for genes affiliated with Morbid Obesity

About this section

Cellular components related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7ENPP1, CARTPT, LEP, PYY, AGRP
2integral component of plasma membraneGO:0058879.2MC3R, NPY1R, ENPP1, ADRB2, ADRA2B, ADRB3
3plasma membraneGO:0058868.8MRAP2, MC3R, MC4R, AQP7, ADRB3, ADRA2B

Biological processes related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1heat generationGO:03164910.5ADRB3, ADRB2
2desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.5ADRB3, ADRB2
3vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.5ADRB3, ADRB2
4negative regulation of glucagon secretionGO:07009310.5LEP, CARTPT
5diet induced thermogenesisGO:00202410.5ADRB2, ADRB3, MC4R
6adrenergic receptor signaling pathwayGO:07187510.4ADRB2, ADRB3
7negative regulation of appetiteGO:03209910.4CARTPT, LEP
8positive regulation of cAMP biosynthetic processGO:03081910.4MC4R, MC3R, MRAP2
9response to coldGO:00940910.4UCP3, ADRB2, ADRB3, PPARG
10positive regulation of transmission of nerve impulseGO:05197110.4CARTPT, HCRT
11adult feeding behaviorGO:00834310.3LEP, CARTPT, AGRP
12negative regulation of multicellular organism growthGO:04001510.3ADRB3, ADRB2
13adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.3MC3R, MC4R, ADRB3, ADRB2
14brown fat cell differentiationGO:05087310.3PPARG, ADRB3, ADRB2, UCP1
15G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3MC3R, ADRB3, NPY1R
16generation of precursor metabolites and energyGO:00609110.3AQP7, ADRB3, ENPP1
17positive regulation of MAPK cascadeGO:04341010.3LEP, ADRB3, ADRB2
18response to insulinGO:03286810.3LEP, MC4R, UCP3, AGRP
19energy reserve metabolic processGO:00611210.2MRAP2, LEP, MC4R, ADRB3
20mitochondrial transportGO:00683910.2UCP1, UCP3
21activation of adenylate cyclase activityGO:00719010.2ADRB3, ADRB2
22regulation of blood pressureGO:00821710.2NPY1R, MC3R, LEP, PPARG
23positive regulation of blood pressureGO:04577710.1CARTPT, ADRA2B
24insulin secretionGO:03007310.1MC4R, LEP
25feeding behaviorGO:00763110.1MRAP2, PYY, MC4R, NPY1R, AGRP
26neuropeptide signaling pathwayGO:00721810.1HCRT, CARTPT, NPY1R, AGRP
27eating behaviorGO:04275510.0AGRP, ADRB3, LEP, HCRT, PYY
28G-protein coupled receptor signaling pathwayGO:00718610.0PPARG, PYY, ADRA2B, CARTPT
29proton transportGO:0159929.9UCP3, UCP1

Molecular functions related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.4UCP1, UCP3
2melanocyte-stimulating hormone receptor activityGO:00498010.4MC4R, MC3R
3norepinephrine bindingGO:05138010.4ADRB2, ADRB3
4epinephrine bindingGO:05137910.3ADRB3, ADRA2B
5melanocortin receptor activityGO:00497710.3MC3R, MC4R
6neuropeptide bindingGO:04292310.2MC4R, MC3R
7peptide hormone bindingGO:01704610.2MC4R, MC3R
8neuropeptide hormone activityGO:0051849.9AGRP, PYY
9protein bindingGO:0055158.8PPARG, PYY, MC3R, MC4R, ADRB3, ADRA2B

Products for genes affiliated with Morbid Obesity

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Morbid Obesity

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet