MCID: MRB003
MIFTS: 66

Morbid Obesity malady

Genetic diseases (common) category
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Summaries for Morbid Obesity

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47OMIM, 33MalaCards
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Fully expand this MalaCard
MalaCards: Morbid Obesity, also known as obesity, severe, is related to obesity and prader-willi syndrome. An important gene associated with Morbid Obesity is SIM1 (single-minded family bHLH transcription factor 1), and among its related pathways are Syndecan-3-mediated signaling events and The fatty acid cycling model. The compounds [125i]shu9119 and hs014 have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and bone, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Description from OMIM:47 601665

Aliases & Classifications for Morbid Obesity

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8Disease Ontology, 22GTR, 10DISEASES, 47OMIM, 45Novoseek, 62UMLS, 27ICD9CM, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

morbid obesity 8 22 10
obesity, severe 47
obesity, morbid 62
severe obesity 8
obesity morbid 45


External Ids:

Disease Ontology8 DOID:11981
ICD9CM27 278.01
MeSH35 D009767
NCIt40 C34858

Related Diseases for Morbid Obesity

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17GeneCards, 18GeneDecks
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Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.2ADRB2, UCP1, ADRB3
2prader-willi syndrome30.8AGRP, LEP, HCRT
3fatty liver disease30.6PPARG, LEP, ADRB3, FABP2
4insulin resistance30.6PPARG, LEP, MC3R, MC4R, AQP7, ADRB3
5diabetes mellitus30.6ADRB3, PPARG, MC4R, FABP2, UCP3, UCP1
6eating disorder30.4AGRP, MC4R, HCRT, LEP
7hypertension30.4ADRB2, PPARG, LEP, ADRB3
8anorexia nervosa30.4MC4R, AGRP, MC3R, LEP, HCRT
9obstructive sleep apnea30.4HCRT, LEP
10type 2 diabetes mellitus30.2UCP1, UCP3, ADRB2, ADRB3, FABP2, LEP
11polycystic ovary syndrome30.0ADRB3, LEP, PPARG
12hyperuricemia30.0FABP2, ADRB3
13metabolic syndrome x29.9LEP, PPARG
14hyperglycemia29.8ADRB3, LEP, PPARG
15atherosclerosis29.8ADRB2, LEP, UCP1, UCP3, FABP2, ADRB3
16duodenitis10.5
17liver disease10.5
18esophagitis10.4
19gastroesophageal reflux disease10.4
20hepatitis10.4
21thyroiditis10.4
22gastric outlet obstruction10.3
23intussusception10.3
24adenocarcinoma10.3
25hypogonadism10.3
26pancreatitis10.3
27sleep apnea10.3
28leptin receptor deficiency10.3
29endotheliitis10.3
30crohn's disease10.2
31wernicke encephalopathy10.2
32portal vein thrombosis10.2
33hypoglycemia10.2
34situs inversus10.2
35gastric dilatation10.2
36megaesophagus10.2
37craniopharyngioma10.2
38elephantiasis10.2
39gallbladder disease10.2
40pneumonia10.2
41pseudohypoparathyroidism10.2
42vaginitis10.2
43thromboembolism10.2
44morbid obesity and spermatogenic failure10.2
45venous thromboembolism10.2
46blindness10.2
47bulimia nervosa10.1MC4R, LEP
48bronchitis10.1LEP, MC4R, AGRP
49alexithymia10.1
50obesity, severe, and type ii diabetes10.1

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Symptoms for Morbid Obesity

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47OMIM
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Clinical features from OMIM:

601665

Drugs & Therapeutics for Morbid Obesity

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Genetic Tests for Morbid Obesity

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22GTR
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Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity22

Anatomical Context for Morbid Obesity

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33MalaCards
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MalaCards organs/tissues related to Morbid Obesity:

33
Liver, Thyroid, Bone, Heart, Kidney, Monocytes, Endothelial, Adipocyte, Pituitary, Colon, Skin, Testes, Lung, Brain, Pancreas, Small intestine, Spinal cord, Nk cells, Ovary, Breast, Skeletal muscle

Animal Models for Morbid Obesity or affiliated genes

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37MGI
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Publications for Morbid Obesity

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52PubMed
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Articles related to Morbid Obesity:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Morbid obesity predisposes trauma patients to worse outcomes: A National Trauma Data Bank analysis. (24368375)
2014
2
The Mini-Gastric Bypass in the Management of Morbid Obesity in Prader-Willi Syndrome: A Viable Option? (24063639)
2013
3
Aortic injuries during laparoscopic gastric bypass for morbid obesity in Sweden 2009-2010: a nationwide survey. (24209880)
2013
4
Prolonged benzodiazepine coma as a complication of morbid obesity. (23633162)
2013
5
The role of drainage after Roux-en-Y gastric bypass for morbid obesity: A systematic review. (24355318)
2013
6
Economic evaluation of bariatric surgery to combat morbid obesity: a study from the West of Scotland. (23834746)
2013
7
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report. (23043774)
2012
8
Gastrogastric herniation: an unusual complication following greater curve plication for the treatment of morbid obesity. (22391359)
2012
9
Chylous ascites mimicking peritonitis after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (20947450)
2012
10
Pregnancy following gastric by-pass for morbid obesity. (23025232)
2012
11
Are we prepared for a growing population? Morbid obesity and its implications in Irish emergency departments. (21862929)
2012
12
Gastric plication for morbid obesity: a systematic review. (22960951)
2012
13
SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. (22476829)
2012
14
Roux-en-Y gastric bypass vs gastric banding for morbid obesity: a case-matched study of 442 patients. (22249850)
2012
15
Assessment of radiofrequency device sensitivity for the detection of retained surgical sponges in patients with morbid obesity. (23070411)
2012
16
Extreme morbid obesity and labor outcome in nulliparous women at term. (21660900)
2011
17
Evaluation of therapeutic anticoagulation with enoxaparin and associated anti-Xa monitoring in patients with morbid obesity: a case series. (21465129)
2011
18
Transoral gastroplasty for morbid obesity: a multicenter trial with a 1-year outcome. (22136774)
2011
19
Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. (21459682)
2011
20
Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. (20106640)
2011
21
Peripheral polyneuropathy after bariatric surgery for morbid obesity. (22175046)
2011
22
Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda. (21479752)
2011
23
Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment induced by morbid obesity. (20803097)
2011
24
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
25
Treatment of morbid obesity and hiatal paraesophageal hernia by laparoscopic Roux-en-Y gastric bypass. (18773250)
2010
26
Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity. (22053606)
2010
27
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. (20830466)
2010
28
Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. (18463932)
2010
29
Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism. (20226921)
2010
30
Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. (18830789)
2010
31
T-tube gastrostomy as a novel approach for distal staple line disruption after sleeve gastrectomy for morbid obesity: case report and review of the literature. (19575273)
2010
32
Influence of weight reduction on leptin concentration and bone mineral density in patients with morbid obesity before and 6 months after bariatric surgery]. (19396752)
2009
33
Morbid obesity in an adolescent with Prader-Willi syndrome. (19543650)
2009
34
Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry. (19572113)
2009
35
G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patients with morbid obesity]. (20049372)
2009
36
Stoma obstruction after laparoscopic adjustable gastric banding for morbid obesity: report of two cases and treatment options. (18721232)
2008
37
Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity. (17431897)
2008
38
Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. (18779208)
2008
39
Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. (16546195)
2007
40
Digestive Adaptation with Intestinal Reserve: a neuroendocrine-based operation for morbid obesity. (17059749)
2006
41
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
42
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. (14964537)
2004
43
Nutritional markers following duodenal switch for morbid obesity. (14980039)
2004
44
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
45
Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. (15114294)
2002
46
Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. (11756707)
2002
47
Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]. (11594118)
2001
48
Association of poorly controlled diabetes with low serum leptin in morbid obesity. (9226485)
1997
49
Markers for the gene ob and serum leptin levels in human morbid obesity. (9150718)
1997
50
Atrophic beriberi. A complication of jejunoileal bypass surgery for morbid obesity. (210663)
1978

Variations for Morbid Obesity

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Morbid Obesity:

64 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Morbid Obesity:

1 (show all 25)
id Gene Name Type Significance SNP ID Assembly Location
1MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
2MC4RMC4R, 4-BP INS, NT732insertionPathogenic
3MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
4MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenic, Uncertain significancers13447325GRCh37Chr 18, 58039473: 58039473
5MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
6MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
7MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
8MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
9MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
10MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
11MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
12MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
13MC4RMC4R, ILE125LYSundetermined variantPathogenic
14MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
15MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
16MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
17MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
18MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
19MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
20MC4RMC4R, 15-BP DELdeletionPathogenic
21MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
22MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
23MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
24MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
25MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687

Expression for genes affiliated with Morbid Obesity

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Morbid Obesity

Search GEO for disease gene expression data for Morbid Obesity.

Pathways for genes affiliated with Morbid Obesity

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 51PharmGKB, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AGRP, MC4R
2
Show member pathways
10.0UCP1, UCP3
39.8UCP1, LEP, PPARG
4
Show member pathways
9.6PPARG, LEP, UCP3, UCP1
5
Show member pathways
9.6ADRB3, ADRA2B, ADRB2
69.5ADRA2B, ADRB2, NPY1R
7
Show member pathways
fatty acid beta-oxidation VI (peroxisome)38
9.4UCP1, FABP2, AQP7, PPARG
8
Show member pathways
9.4UCP1, ADRB2, ADRB3, PPARG
99.2MC5R, MC3R, MC4R, AGRP
108.8MC5R, MC3R, MC4R, ADRB3, ADRB2
11
Show member pathways
Peptide GPCRs38
8.8HCRT, MC5R, MC3R, MC4R, NPY1R
12
Show member pathways
6.8NPY1R, HCRT, LEP, APLN, MC5R, MC3R
13
Show member pathways
6.8HCRT, LEP, APLN, MC5R, MC3R, MC4R

Compounds for genes affiliated with Morbid Obesity

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Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB
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Compounds related to Morbid Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1[125i]shu91192910.3MC4R, MC3R
2hs0142910.3MC4R, MC3R
3stavudine45 1111.2LEP, UCP1, PPARG
4ici 1185512910.1ADRB3, ADRB2
5carazolol45 2911.1ADRB3, ADRB2
6isoprenaline2910.0ADRB3, ADRB2
7[125i]icyp2910.0ADRB2, ADRB3
8thiazolidinedione4510.0LEP, UCP1, UCP3, PPARG
9clenbuterol45 1111.0ADRB2, LEP, ADRB3
10oxyntomodulin45 6111.0AGRP, LEP, HCRT
11cgp 1217729 4511.0ADRB3, ADRB2
12(plusmn)-adrenaline2910.0ADRA2B, ADRB3
13sr59230a299.9ADRB2, ADRB3
14olanzapine45 51 29 24 1113.9MC4R, ADRA2B, ADRB3, LEP
15rosiglitazone29 45 51 24 1113.9PPARG, LEP, UCP1, UCP3
16bezafibrate45 29 1111.9UCP3, PPARG, UCP1
17salbutamol45 51 29 24 1113.9UCP3, ADRB3, ADRB2
18pg-901299.9MC5R, MC3R, MC4R
19agouti-related protein299.9MC4R, MC3R, MC5R
20hs024299.9MC4R, MC3R, MC5R
21ndp-msh299.9MC5R, MC3R, MC4R
22shu9119299.9MC3R, MC5R, MC4R
23[125i]ndp-msh299.9MC4R, MC5R, MC3R
24mt-ii299.9MC4R, MC3R, MC5R
25corticosterone45 61 2411.8LEP, MC3R, HCRT, MC4R
26alpha-msh61 2910.8MC4R, MC5R, MC3R
27hs 014619.8MC3R, MC4R, MC5R
28pg 106619.8MC4R, MC3R, MC5R
29[d-trp8]-gamma-msh619.8MC5R, MC3R, MC4R
30c-peptide459.8ADRB3, HCRT, UCP1, LEP
31bupranolol29 45 1111.7ADRB2, ADRB3
32pgc1459.7UCP1, PPARG
33thyroxine45 2410.7PPARG, HCRT, LEP, UCP1
34palmitate459.7UCP3, MC4R, PPARG, UCP1, FABP2
35shu 911961 4510.7LEP, MC5R, MC4R, MC3R
36clozapine45 29 51 1112.6ADRB2, ADRB3, ADRA2B, MC4R, LEP
37catecholamine459.5UCP1, HCRT, ADRB3, ADRB2
38alpha msh459.4LEP, MC5R, MC3R, MC4R, AGRP
39glycerol45 24 1111.4LEP, PPARG, ADRB2, AQP7
40epinephrine45 24 1111.3ADRB3, ADRA2B, ADRB2, LEP, HCRT
41cocaine45 1110.3AGRP, HCRT, LEP, MC3R, MC4R, ADRB2
42acth459.1MC3R, MC5R, LEP, HCRT, AGRP, MC4R
43fatty acid459.1PPARG, LEP, MC4R, ADRB3, FABP2, UCP3
44norepinephrine45 24 1111.0ADRB2, LEP, ADRB3, ADRA2B, UCP1, UCP3
45estrogen458.9ADRB2, NPY1R, LEP, ADRB3, HCRT, UCP3
46nitric oxide45 24 1110.1NPY1R, UCP3, ADRB3, MC4R, APLN, HCRT
47alanine458.1HCRT, PPARG, FABP2, APLN, ADRB3, ADRB2
48cholesterol45 29 24 1110.9UCP3, LEP, APLN, UCP1, MC4R, ADRB3
49lipid457.7UCP3, MC5R, UCP1, FABP2, ADRB2, ADRB3
50glucose457.0MC3R, PPARG, AGRP, UCP1, UCP3, FABP2

GO Terms for genes affiliated with Morbid Obesity

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16Gene Ontology
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Cellular components related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.0MC3R, MC4R, AQP7, ADRB3, ADRA2B, ADRB2
2integral component of plasma membraneGO:0058877.9NPY1R, MC5R, MC3R, AQP7, ADRB3, ADRA2B

Biological processes related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.2LEP, AGRP
2heat generationGO:03164910.1ADRB3, ADRB2
3desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.1ADRB3, ADRB2
4vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.1ADRB3, ADRB2
5insulin secretionGO:03007310.1MC4R, LEP
6feeding behaviorGO:00763110.0MC4R, NPY1R, AGRP
7adrenergic receptor signaling pathwayGO:07187510.0ADRB2, ADRB3
8mitochondrial transportGO:00683910.0UCP1, UCP3
9energy reserve metabolic processGO:00611210.0ADRB3, MC4R, LEP
10diet induced thermogenesisGO:00202410.0ADRB2, ADRB3, MC4R
11negative regulation of multicellular organism growthGO:0400159.9ADRB3, ADRB2
12regulation of blood pressureGO:0082179.9PPARG, LEP, MC3R, NPY1R
13positive regulation of MAPK cascadeGO:0434109.8LEP, ADRB3, ADRB2
14eating behaviorGO:0427559.8HCRT, LEP, ADRB3, AGRP
15response to coldGO:0094099.8PPARG, ADRB3, ADRB2, UCP3
16adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:0071889.8ADRB2, ADRB3, MC4R, MC3R
17activation of adenylate cyclase activityGO:0071909.7ADRB2, ADRB3
18positive regulation of cAMP biosynthetic processGO:0308199.7MC4R, MC3R, MC5R
19brown fat cell differentiationGO:0508739.7UCP1, ADRB2, ADRB3, PPARG
20proton transportGO:0159929.7UCP1, UCP3
21neuropeptide signaling pathwayGO:0072189.7AGRP, NPY1R, HCRT
22negative regulation of vasoconstrictionGO:0459069.7APLN, LEP
23response to insulinGO:0328689.6AGRP, UCP3, MC4R, LEP, INSIG2
24G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.4MC5R, MC3R, ADRB3, NPY1R

Molecular functions related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1melanocyte-stimulating hormone receptor activityGO:00498010.1MC4R, MC3R
2oxidative phosphorylation uncoupler activityGO:01707710.1UCP1, UCP3
3peptide hormone bindingGO:01704610.1MC4R, MC3R
4epinephrine bindingGO:0513799.9ADRA2B, ADRB3
5norepinephrine bindingGO:0513809.8ADRB3, ADRB2
6neuropeptide bindingGO:0429239.8MC4R, MC3R
7melanocortin receptor activityGO:0049779.6MC4R, MC3R, MC5R

Products for genes affiliated with Morbid Obesity

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Morbid Obesity

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet