MCID: MRB003
MIFTS: 68

Morbid Obesity malady

Genetic diseases (common), Metabolic diseases categories
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Summaries for Morbid Obesity

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MalaCards based summary: Morbid Obesity, also known as obesity, severe, is related to obesity and prader-willi syndrome. An important gene associated with Morbid Obesity is SIM1 (single-minded family bHLH transcription factor 1), and among its related pathways are Syndecan-3-mediated signaling events and The fatty acid cycling model. The compounds carazolol and ici 118551 have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Description from OMIM:46 601665

Aliases & Classifications for Morbid Obesity

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Morbid Obesity, Aliases & Descriptions:

Name: Morbid Obesity 30 8 22 10
Obesity, Severe 46
Obesity, Morbid 62
 
Severe Obesity 8
Obesity Morbid 44


Classifications:



External Ids:

Disease Ontology8 DOID:11981
ICD9CM27 278.01
MeSH34 D009767
NCIt39 C34858

Related Diseases for Morbid Obesity

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Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.5PPARG, MC4R, UCP3
2prader-willi syndrome31.3LEP, AGRP, PYY
3fatty liver disease31.1FABP2, ADRB3, LEP, PPARG
4eating disorder31.1MC4R, LEP, PYY, AGRP
5anorexia nervosa30.9LEP, MC3R, AGRP, MC4R, PYY
6hypertension30.8LEP, PPARG, ADRB2, ADRB3
7constipation30.7PYY
8polycystic ovary syndrome30.5ADRB3, LEP, PPARG
9metabolic syndrome x30.4LEP, PPARG
10insulin resistance30.3ADRB3, UCP1, PPARG, FABP2, PYY, ADRB2
11hyperuricemia30.2FABP2, ADRB3
12diabetes mellitus30.0GAD1, UCP1, UCP3, FABP2, ADRB3, MC4R
13hyperglycemia29.7PPARG, ADRB3, GAD1, LEP, ENPP1, PYY
14atherosclerosis29.7PPARG, UCP3, UCP1, ENPP1, LEP, FABP2
15type 2 diabetes mellitus29.6ENPP1, GAD1, UCP1, UCP3, FABP2, ADRB2
16duodenitis10.5
17liver disease10.5
18esophagitis10.5
19double outlet right ventricle10.4MC4R, LEP, PYY
20non-suppurative otitis media10.4MC4R, AGRP, LEP
21bulimia nervosa10.4PYY, LEP, MC4R
22gastroesophageal reflux disease10.4
23hepatitis10.4
24essential hypertension10.4ADRB3, ADRB2, ADRA2B, LEP
25familial partial lipodystrophy10.3PPARG, LEP
26hypogonadism10.3
27thyroiditis10.3
28gastric outlet obstruction10.3
29congenital generalized lipodystrophy type 210.3PPARG, LEP
30hyperinsulinism10.3MC4R, LEP, PPARG
31hyperandrogenism10.3MC4R, LEP, PPARG
32familial combined hyperlipidemia10.3ADRB3, FABP2
33pre-eclampsia10.3ADRB2, LEP, ADRB3
34hypertriglyceridemia10.3LEP, FABP2, PPARG, ADRB3
35jejunoileitis10.3
36intussusception10.3
37adenocarcinoma10.3
38elephantiasis10.3
39pancreatitis10.3
40endotheliitis10.3
41pheochromocytoma10.2UCP1, ADRB2, PYY
42congenital heart disease10.2PPARG, LEP, ADRB2
43glucose intolerance10.2PPARG, ADRB3, LEP, ENPP1
44crohn's disease10.2
45wernicke encephalopathy10.2
46situs inversus10.2
47megaesophagus10.2
48portal vein thrombosis10.2
49hypoglycemia10.2
50gastroparesis10.2

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Symptoms for Morbid Obesity

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Clinical features from OMIM:

601665

Drugs & Therapeutics for Morbid Obesity

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Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Genetic Tests for Morbid Obesity

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Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity22

Anatomical Context for Morbid Obesity

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MalaCards organs/tissues related to Morbid Obesity:

32
Liver, Kidney, Bone, Thyroid, Heart, Adipocyte, Monocytes, Endothelial, Colon, Lung, Pancreas, Skin, Testes, Pituitary, Neutrophil, Brain, Spinal cord, Skeletal muscle, Small intestine, Breast, Ovary, Nk cells

Animal Models for Morbid Obesity or affiliated genes

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Publications for Morbid Obesity

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Articles related to Morbid Obesity:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice. (24990938)
2014
2
Impact of Recipient Morbid Obesity on Outcomes After Liver Transplantation. (25363625)
2014
3
Morbid obesity predisposes trauma patients to worse outcomes: A National Trauma Data Bank analysis. (24368375)
2014
4
The Mini-Gastric Bypass in the Management of Morbid Obesity in Prader-Willi Syndrome: A Viable Option? (24063639)
2013
5
Aortic injuries during laparoscopic gastric bypass for morbid obesity in Sweden 2009-2010: a nationwide survey. (24209880)
2013
6
Prolonged benzodiazepine coma as a complication of morbid obesity. (23633162)
2013
7
The role of drainage after Roux-en-Y gastric bypass for morbid obesity: A systematic review. (24355318)
2013
8
Economic evaluation of bariatric surgery to combat morbid obesity: a study from the West of Scotland. (23834746)
2013
9
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report. (23043774)
2012
10
Gastrogastric herniation: an unusual complication following greater curve plication for the treatment of morbid obesity. (22391359)
2012
11
Chylous ascites mimicking peritonitis after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (20947450)
2012
12
Pregnancy following gastric by-pass for morbid obesity. (23025232)
2012
13
Are we prepared for a growing population? Morbid obesity and its implications in Irish emergency departments. (21862929)
2012
14
Gastric plication for morbid obesity: a systematic review. (22960951)
2012
15
SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. (22476829)
2012
16
Roux-en-Y gastric bypass vs gastric banding for morbid obesity: a case-matched study of 442 patients. (22249850)
2012
17
Assessment of radiofrequency device sensitivity for the detection of retained surgical sponges in patients with morbid obesity. (23070411)
2012
18
Extreme morbid obesity and labor outcome in nulliparous women at term. (21660900)
2011
19
Evaluation of therapeutic anticoagulation with enoxaparin and associated anti-Xa monitoring in patients with morbid obesity: a case series. (21465129)
2011
20
Transoral gastroplasty for morbid obesity: a multicenter trial with a 1-year outcome. (22136774)
2011
21
Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. (21459682)
2011
22
Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. (20106640)
2011
23
Peripheral polyneuropathy after bariatric surgery for morbid obesity. (22175046)
2011
24
Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda. (21479752)
2011
25
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
26
Treatment of morbid obesity and hiatal paraesophageal hernia by laparoscopic Roux-en-Y gastric bypass. (18773250)
2010
27
Effect of surgically-induced weight loss on inflammatory mediators and peripheral blood monocyte CD11b expression in morbid obesity. (22053606)
2010
28
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. (20830466)
2010
29
Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. (18463932)
2010
30
Influence of morbid obesity on parathyroidectomy outcomes in primary hyperparathyroidism. (20226921)
2010
31
Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. (18830789)
2010
32
T-tube gastrostomy as a novel approach for distal staple line disruption after sleeve gastrectomy for morbid obesity: case report and review of the literature. (19575273)
2010
33
Influence of weight reduction on leptin concentration and bone mineral density in patients with morbid obesity before and 6 months after bariatric surgery]. (19396752)
2009
34
Morbid obesity in an adolescent with Prader-Willi syndrome. (19543650)
2009
35
Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry. (19572113)
2009
36
G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patients with morbid obesity]. (20049372)
2009
37
Stoma obstruction after laparoscopic adjustable gastric banding for morbid obesity: report of two cases and treatment options. (18721232)
2008
38
Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity. (17431897)
2008
39
Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. (18779208)
2008
40
Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients. (16546195)
2007
41
Digestive Adaptation with Intestinal Reserve: a neuroendocrine-based operation for morbid obesity. (17059749)
2006
42
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
43
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus. (14964537)
2004
44
Nutritional markers following duodenal switch for morbid obesity. (14980039)
2004
45
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
46
Obesity-related non-alcoholic steatohepatitis and TGF-beta1 serum levels in relation to morbid obesity. (15114294)
2002
47
Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. (11756707)
2002
48
Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]. (11594118)
2001
49
Association of poorly controlled diabetes with low serum leptin in morbid obesity. (9226485)
1997
50
Atrophic beriberi. A complication of jejunoileal bypass surgery for morbid obesity. (210663)
1978

Variations for Morbid Obesity

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UniProtKB/Swiss-Prot genetic disease variations for Morbid Obesity:

64 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Morbid Obesity:

6 (show all 39)
id Gene Name Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
30MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
31MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
32MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
33MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
34NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
35NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
36MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
37CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
38PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
39MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Morbid Obesity

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Expression patterns in normal tissues for genes affiliated with Morbid Obesity

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Pathways for genes affiliated with Morbid Obesity

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Pathways related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2AGRP, MC4R
2
Show member pathways
10.2UCP3, UCP1
3
Show member pathways
10.0ADRB2, ADRA2B, ADRB3
410.0MC4R, AGRP, MC3R
510.0LEP, UCP1, PPARG
6
Show member pathways
Peptide GPCRs37
10.0MC3R, MC4R, NPY1R
79.9ADRB2, ADRB3, MC4R, MC3R
8
Show member pathways
9.9ADRB2, PPARG, UCP1, ADRB3
99.8NPY1R, ADRB2, ADRA2B, PYY
10
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.8UCP1, FABP2, AQP7, PPARG
11
Show member pathways
9.7MT-CYB, PPARG, UCP3, UCP1, LEP
12
Show member pathways
9.3ADRB3, NPY1R, ADRB2, ADRA2B, MC4R, MC3R
13
Show member pathways
9.3PYY, NPY1R, LEP, ADRB2, ADRA2B, ADRB3

Compounds for genes affiliated with Morbid Obesity

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Compounds related to Morbid Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1carazolol44 2811.5ADRB2, ADRB3
2ici 1185512810.5ADRB3, ADRB2
3[125i]shu91192810.5MC4R, MC3R
4[125i]icyp2810.5ADRB3, ADRB2
5cgp 1217728 4411.5ADRB2, ADRB3
6sr59230a2810.5ADRB2, ADRB3
7clenbuterol44 1111.5ADRB3, ADRB2, LEP
8isoprenaline2810.4ADRB2, ADRB3
9shu 911961 4411.4MC3R, LEP, MC4R
10intralipid4410.4LEP, PYY, UCP3
11orlistat44 61 1112.4LEP, PYY, PPARG
12hs0142810.4MC3R, MC4R
13stavudine44 1111.4PPARG, LEP, UCP1
14salbutamol44 50 28 24 1114.4ADRB3, UCP3, ADRB2
15agouti-related protein2810.4MC4R, MC3R
16oxyntomodulin44 6111.4PYY, AGRP, LEP
17pg-9012810.3MC3R, MC4R
18amphetamine44 50 1112.3CARTPT, PYY, MC4R, AGRP
19thiazolidinedione4410.3PPARG, LEP, UCP3, UCP1
20alpha msh4410.3AGRP, MC3R, LEP, MC4R
21olanzapine44 50 28 24 1114.3LEP, MC4R, ADRB3, ADRA2B
22rosiglitazone28 44 50 24 1114.2PPARG, LEP, UCP3, UCP1
232-deoxyglucose44 1111.2GAD1, UCP3, PYY, PPARG, AGRP
24p0034410.2LEP, UCP3, UCP1, PYY
25procaterol44 28 1112.2ADRB3, ADRB2
26c-peptide4410.2PYY, GAD1, ADRB3, UCP1, LEP
27palmitate4410.1UCP3, FABP2, UCP1, MC4R, PPARG
28bezafibrate44 28 1112.1PPARG, UCP3, UCP1
29gnrh4410.1MC3R, ADRB2, GAD1, PYY, LEP
30acth4410.1LEP, PYY, MC4R, AGRP, MC3R
31clozapine44 28 50 1113.1ADRB2, GAD1, MC4R, ADRA2B, LEP, ADRB3
32gtp44 2811.1ADRB2, UCP1, PYY, UCP3, MT-CYB
33dopamine44 28 24 1113.0GAD1, MC3R, PYY, MC4R, CARTPT, ADRB2
34cocaine44 1110.9LEP, MC3R, PYY, MC4R, AGRP, ADRB2
35ndp-msh289.9MC3R, MC4R
36norepinephrine44 24 1111.9UCP3, UCP1, ADRB2, ADRA2B, ADRB3, LEP
37cyclic amp44 2410.9UCP1, PYY, MC3R, ADRB3, ADRB2, ENPP1
38estrogen449.9NPY1R, UCP3, PPARG, PYY, ADRB3, LEP
39hydrogen44 2410.8UCP1, PYY, MT-CYB, FABP2, GAD1, ADRB2
40glycerol44 24 1111.8LEP, ADRB2, PPARG, AQP7
41arginine449.8ADRB2, MC4R, ADRB3, LEP, PYY, GAD1
42nitric oxide44 24 1111.7NPY1R, MC4R, ADRB3, MT-CYB, ADRB2, UCP3
43alanine449.7PPARG, FABP2, GAD1, ADRB3, MT-CYB, ADRB2
44atp44 2810.5AGRP, UCP1, PYY, ADRB3, MT-CYB, UCP3
45glutamate449.5ADRA2B, LEP, GAD1, UCP1, ADRB2, MT-CYB
46fatty acid449.5AGRP, PPARG, PYY, UCP3, LEP, MC4R
47calcium44 50 24 1112.5ENPP1, GAD1, PYY, MC4R, MT-CYB, UCP3
48cholesterol44 28 24 1112.4UCP1, MC4R, UCP3, FABP2, ADRA2B, PPARG
49lipid449.2ADRB3, MT-CYB, UCP1, MC3R, LEP, PPARG
50glucose448.7PPARG, AGRP, ENPP1, GAD1, UCP1, UCP3

GO Terms for genes affiliated with Morbid Obesity

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Cellular components related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7PYY, LEP, CARTPT, ENPP1, AGRP
2integral component of plasma membraneGO:0058879.2MC3R, NPY1R, ENPP1, ADRB2, ADRA2B, ADRB3
3plasma membraneGO:0058868.6MRAP2, MC3R, MC4R, AQP7, ADRB3, NPY1R

Biological processes related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1heat generationGO:03164910.5ADRB3, ADRB2
2desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.5ADRB3, ADRB2
3vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.5ADRB3, ADRB2
4negative regulation of glucagon secretionGO:07009310.5LEP, CARTPT
5diet induced thermogenesisGO:00202410.5ADRB2, ADRB3, MC4R
6adrenergic receptor signaling pathwayGO:07187510.4ADRB3, ADRB2
7negative regulation of appetiteGO:03209910.4LEP, CARTPT
8response to coldGO:00940910.4UCP3, ADRB2, ADRB3, PPARG
9positive regulation of cAMP biosynthetic processGO:03081910.4MRAP2, MC3R, MC4R
10adult feeding behaviorGO:00834310.3LEP, CARTPT, AGRP
11negative regulation of multicellular organism growthGO:04001510.3ADRB3, ADRB2
12adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.3MC3R, MC4R, ADRB3, ADRB2
13positive regulation of MAPK cascadeGO:04341010.3ADRB2, ADRB3, LEP
14brown fat cell differentiationGO:05087310.3PPARG, ADRB3, ADRB2, UCP1
15G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3NPY1R, ADRB3, MC3R
16generation of precursor metabolites and energyGO:00609110.3AQP7, ADRB3, ENPP1
17eating behaviorGO:04275510.3PYY, LEP, ADRB3, AGRP
18response to insulinGO:03286810.3LEP, MC4R, UCP3, AGRP
19energy reserve metabolic processGO:00611210.2MRAP2, LEP, MC4R, ADRB3
20mitochondrial transportGO:00683910.2UCP1, UCP3
21activation of adenylate cyclase activityGO:00719010.2ADRB3, ADRB2
22regulation of blood pressureGO:00821710.2NPY1R, MC3R, LEP, PPARG
23positive regulation of blood pressureGO:04577710.1CARTPT, ADRA2B
24neuropeptide signaling pathwayGO:00721810.1AGRP, NPY1R, CARTPT
25insulin secretionGO:03007310.1MC4R, LEP
26feeding behaviorGO:00763110.1AGRP, NPY1R, MC4R, PYY, MRAP2
27G-protein coupled receptor signaling pathwayGO:00718610.1PPARG, PYY, ADRA2B, CARTPT
28proton transportGO:0159929.9UCP3, UCP1

Molecular functions related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1norepinephrine bindingGO:05138010.4ADRB2, ADRB3
2oxidative phosphorylation uncoupler activityGO:01707710.4UCP1, UCP3
3melanocyte-stimulating hormone receptor activityGO:00498010.4MC4R, MC3R
4epinephrine bindingGO:05137910.2ADRB3, ADRA2B
5melanocortin receptor activityGO:00497710.2MC3R, MC4R
6peptide hormone bindingGO:01704610.2MC4R, MC3R
7neuropeptide bindingGO:04292310.1MC4R, MC3R
8neuropeptide hormone activityGO:0051849.9AGRP, PYY
9protein bindingGO:0055158.9ADRB3, MC4R, MC3R, PYY, PPARG, ADRA2B

Products for genes affiliated with Morbid Obesity

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Sources for Morbid Obesity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet