MCID: MRB003
MIFTS: 68

Morbid Obesity malady

Metabolic diseases category

Summaries for Morbid Obesity

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46OMIM, 32MalaCards
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MalaCards: Morbid Obesity, also known as obesity, severe, is related to obesity and diabetes mellitus. An important gene associated with Morbid Obesity is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and PPAR signaling pathway. The compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and bone, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Description from OMIM:46 601665

Aliases & Classifications for Morbid Obesity

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

morbid obesity 8 22 10
obesity, severe 46
obesity, morbid 60
severe obesity 8
obesity morbid 44


External Ids:

Disease Ontology8 DOID:11981
ICD9CM27 278.01
NCIt39 C34858
MeSH34 D009767

Related Diseases for Morbid Obesity

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Morbid Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.0ADRB3, UCP1
2diabetes mellitus30.7ADRB3, PLIN1, LEP, PYY, NAMPT, MC4R
3fatty liver disease30.6UCP2, FABP2, PPARG, LEP, ADRB3
4type 2 diabetes mellitus30.4FABP2, ISL1, UCP3, UCP1, UCP2, CCKAR
5hypertension30.4PPARG, LEP, ADRB3
6anorexia nervosa30.3LEP, MC3R, MC4R, AGRP, PYY
7eating disorder30.3LEP, PYY
8pancreatitis30.3CCKAR
9adenocarcinoma30.3PYY, CCKAR, UCP2
10gallbladder disease30.2CCKAR, PYY
11liver cirrhosis30.2LEP
12atherosclerosis30.0UCP2, UCP1, UCP3, FABP2, FABP4, PPARG
13polycystic ovary syndrome29.9PPARG, LIPE, NAMPT, LEP, ADRB3
14hypothyroidism29.9LEP, AGRP
15constipation29.9PYY
16hyperglycemia29.8PYY, UCP2, PPARG, NAMPT, LEP, ADRB3
17metabolic syndrome x29.8LEP, PPARG
18hyperuricemia29.8ADRB3, FABP2
19duodenitis10.5
20prader-willi syndrome10.5
21liver disease10.4
22esophagitis10.4
23gastroesophageal reflux disease10.4
24gastric dilatation10.3
25hepatitis10.3
26thyroiditis10.3
27gastric ulcer10.3
28intussusception10.2
29hypogonadism10.2
30bone fracture10.1
31megaesophagus10.1
32crohn's disease10.1
33wernicke encephalopathy10.1
34portal vein thrombosis10.1
35hypoglycemia10.1
36situs inversus10.1
37gastroparesis10.1
38craniopharyngioma10.1
39diverticulitis10.1
40elephantiasis10.1
41pneumonia10.1
42pseudohypoparathyroidism10.1
43vaginitis10.1
44alexithymia10.1
45obesity, severe, and type ii diabetes10.0
46obesity, severe bmiq910.0
47insulin resistance10.0UCP1, UCP2, PYY, ADRB3, PLIN1, LEP
48familial hyperlipidemia10.0UCP2, UCP1, UCP3, PPARG, LIPE, NAMPT
49coronary heart disease10.0ADRB3, LEP, LIPE, FABP2, UCP2
50lipodystrophy10.0PPARG, LIPE, LEP, ADRB3

Graphical network of the top 20 diseases related to Morbid Obesity:



Diseases related to morbid obesity

Clinical Features for Morbid Obesity

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46OMIM
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Clinical features from OMIM:

601665

Drugs & Therapeutics for Morbid Obesity

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Morbid Obesity

Drug clinical trials:

Search ClinicalTrials for Morbid Obesity

Search NIH Clinical Center for Morbid Obesity

Search CenterWatch for Morbid Obesity

Genetic Tests for Morbid Obesity

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Sources:
22GTR
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Genetic tests related to Morbid Obesity:

id Genetic test Affiliating Genes
1 Morbid Obesity22

Anatomical Context for Morbid Obesity

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32MalaCards
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MalaCards organs/tissues related to Morbid Obesity:

32
Liver, Thyroid, Bone, Kidney, Heart, Endothelial, Monocytes, Adipocyte, Skin, Testes, Pancreas, Lung, Pituitary, Colon, Breast, Small intestine, Ovary, Spinal cord, Nk cells, Brain, Skeletal muscle

Animal Models for Morbid Obesity or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Morbid Obesity:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.5FABP4, FABP2, ISL1, UCP3, UCP1, UCP2
2MP:000537611.5PPARG, FABP4, FABP2, UCP3, UCP1, UCP2
3MP:000537511.4AQP7, PYY, UCP1, UCP3, FABP2, FABP4
4MP:000538611.3PPARG, ISL1, UCP1, UCP2, CCKAR, PYY
5MP:000537010.9CCKAR, FABP2, FABP4, PPARG, LIPE, MC4R
6MP:000537910.9CCKAR, ISL1, PPARG, LIPE, NAMPT, SIM1
7MP:000538410.9CCKAR, UCP2, UCP1, UCP3, ISL1, PPARG
8MP:000536710.8FABP2, PPARG, SIM1, LEP, AQP7, CCKAR
9MP:000363110.6PYY, CCKAR, UCP2, ISL1, PPARG, AGRP

Publications for Morbid Obesity

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Sources:
50PubMed
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Articles related to Morbid Obesity:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Does morbid obesity worsen outcomes after esophagectomy? (23434257)
2013
2
Particular characteristics of the metabolic syndrome in patients with morbid obesity. (23266153)
2013
3
Morbid obesity may increase dislocation in total hip patients: a biomechanical analysis. (22907474)
2013
4
A 47,X,+t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2),Y Klinefelter variant with morbid obesity. (23364994)
2013
5
Is there any relation between gastric bypass for morbid obesity and the development of Crohn's disease? (24378833)
2013
6
Laparoscopic gastric bypass versus laparoscopic sleeve gastrectomy as a definitive surgical procedure for morbid obesity. Mid-term results. (23196992)
2013
7
Assessment of abdominal fat compartments using DXA in premenopausal women from anorexia nervosa to morbid obesity. (23512706)
2013
8
Morbid obesity and diverticulitis: results from the ACS NSQIP dataset. (24041558)
2013
9
Laparoscopic sleeve gastrectomy for morbid obesity: 5 years experience from an Asian center of excellence. (23462857)
2013
10
Morbid obesity does not disadvantage patients with in situ or early-stage carcinoma undergoing breast-conserving surgery. (24023321)
2013
11
Assessment of radiofrequency device sensitivity for the detection of retained surgical sponges in patients with morbid obesity. (23070411)
2012
12
Morbid obesity is associated with increased resource utilization in coronary artery bypass grafting. (22607785)
2012
13
Laparoscopic sleeve gastrectomy as a stand-alone procedure for morbid obesity: report of 1,000 cases and 3-year follow-up. (22438219)
2012
14
The retinoic acid receptor-related orphan nuclear receptor I^1 (RORI^1): a novel player determinant of insulin sensitivity in morbid obesity. (21904299)
2012
15
Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for morbid obesity: case-control study. (21459682)
2011
16
Laparoscopic resectional gastric bypass in patients with morbid obesity: experience on 112 consecutive patients. (21061177)
2011
17
Constipation and colonic transit times in children with morbid obesity. (21240026)
2011
18
A 5-year prospective quality of life analysis following laparoscopic adjustable gastric banding for morbid obesity. (21553303)
2011
19
Surgical treatment of morbid obesity: mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy in 120 patients. (20652440)
2011
20
Initial experience with robotic sleeve gastrectomy for morbid obesity. (20686929)
2011
21
Perioperative management of morbid obesity. (21874986)
2011
22
Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity. (21660293)
2011
23
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
24
Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. (18463932)
2010
25
Morbid obesity is associated with fear of movement and lower quality of life in patients with knee pain-related diagnoses. (20709300)
2010
26
Morbid obesity in pediatric diabetes mellitus: surgical options and outcomes. (20842181)
2010
27
Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery. (20877950)
2010
28
Initial human experience with restrictive duodenal-jejunal bypass liner for treatment of morbid obesity. (20359665)
2010
29
Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry. (19572113)
2009
30
A prospective randomized study comparing patients with morbid obesity submitted to laparotomic gastric bypass with or without omentectomy. (18712575)
2009
31
Gastroesophageal reflux disease and morbid obesity: is there a relation? (19404705)
2009
32
Experience with laparoscopic sleeve gastrectomy for morbid versus super morbid obesity. (19067089)
2009
33
RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity. (19367438)
2009
34
Safety and short-term outcomes of laparoscopic sleeve gastrectomy as a revisional approach for failed laparoscopic adjustable gastric banding in the treatment of morbid obesity. (19711138)
2009
35
Severe psoriasis, morbid obesity and bariatric surgery. (19747301)
2009
36
Relationship of insulin resistance and adipocytokines on serum alanine aminotransferase in presurgical morbid obese patients. (20085121)
2009
37
A multidisciplinary team for treatment of patients with morbid obesity should include a plastic surgeon. (19237072)
2009
38
Stoma obstruction after laparoscopic adjustable gastric banding for morbid obesity: report of two cases and treatment options. (18721232)
2008
39
Incidence and management of enteric leaks after gastric bypass for morbid obesity during a 10-year period. (18407803)
2008
40
Gastroesophageal reflux in patients with morbid obesity: a role of obstructive sleep apnea syndrome? (18418659)
2008
41
Evolution of the blood parameters after morbid obesity surgery with the duodenal crossing technique]. (19160895)
2008
42
Obesity and morbid obesity are associated with a greater conversion rate to open surgery for standard but not hand assisted laparoscopic radical nephrectomy. (18930284)
2008
43
Morbid obesity and sleep apnea. Is weight loss the answer? (18763425)
2008
44
Does gastric dilatation limit the success of sleeve gastrectomy as a sole operation for morbid obesity? (16469218)
2006
45
Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. (15855267)
2005
46
Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. (11756334)
2002
47
The Gln27Glu polymorphism in the beta2-adrenergic receptor gene is not associated with morbid obesity in Austrian women. (10757636)
2000
48
Markers for the gene ob and serum leptin levels in human morbid obesity. (9150718)
1997
49
Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity. (9416435)
1997
50
Endoscopic management of gastric outlet obstruction following surgery for morbid obesity. (2596768)
1989

Genetic Variations for Morbid Obesity

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Morbid Obesity:

62 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Expression for genes affiliated with Morbid Obesity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Morbid Obesity

Search GEO for disease gene expression data for Morbid Obesity.

Pathways for genes affiliated with Morbid Obesity

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8ADRB3, LEP, MC3R, MC4R, CCKAR, PYY
210.8AQP7, PLIN1, PPARG, FABP4, FABP2, UCP1
3
Hide members
10.7UCP2, UCP1, UCP3, PPARG, LEP
410.7PPARG, LIPE, NAMPT, LEP, PLIN1
5
Hide members
10.7ADRB3, PLIN1, LIPE, PPARG, UCP1
610.7PLIN1, LEP, PPARG, FABP4
710.7FABP4, PPARG, LIPE, PLIN1
810.6PPARG, UCP3, UCP2
910.6AGRP, MC4R, MC3R
10
Hide members
10.6MC3R, MC4R, CCKAR
11
Hide members
10.6UCP2, UCP1, UCP3
12
Hide members
10.6FABP4, LIPE, PLIN1
1310.6FABP4, LIPE, PLIN1
1410.6MC4R, AGRP

Compounds for genes affiliated with Morbid Obesity

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Morbid Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1glucose4411.7PYY, CCKAR, UCP2, UCP1, UCP3, ISL1
2lipid4411.6FABP4, PPARG, LIPE, MC4R, MC3R, NAMPT
3fatty acid4411.6AGRP, PPARG, FABP4, FABP2, UCP3, UCP1
4cholesterol44 28 11 2414.6PYY, CCKAR, UCP2, UCP1, UCP3, FABP2
5rosiglitazone44 49 28 11 2415.3FABP4, PPARG, UCP2, UCP1, LEP, NAMPT
6norepinephrine44 11 2413.3UCP2, UCP1, UCP3, ADRB3, LIPE, LEP
7oleic acid44 28 11 2414.2LIPE, FABP2, UCP2, CCKAR, PYY, FABP4
8thiazolidinedione4411.2UCP3, UCP2, UCP1, PPARG, LEP, FABP4
9palmitate4411.2FABP4, MC4R, FABP2, UCP1, UCP2, UCP3
10cocaine44 1112.2CCKAR, PYY, MC4R, MC3R, LEP, AGRP
11cyclic amp44 2412.2MC3R, PLIN1, LIPE, UCP1, ADRB3, CCKAR
12glycerol44 11 2413.2AQP7, PLIN1, LEP, LIPE, PPARG, FABP4
13pyruvate4411.2LIPE, UCP2, FABP4, FABP2, UCP3, UCP1
142-deoxyglucose44 1112.1UCP3, AGRP, LIPE, PPARG, PYY
15glycerol 3-phosphate44 2412.1PLIN1, FABP4, PPARG, LIPE, LEP
16carnitine4411.1PPARG, UCP2, UCP3, LIPE, UCP1
17triacylglycerol4411.1FABP2, PLIN1, LIPE, LEP, PYY
18acyl-coa4411.1UCP2, UCP3, FABP4, LIPE, PLIN1
19p0034411.1UCP2, PYY, UCP1, UCP3, LEP
20catecholamine4411.1ADRB3, PLIN1, LIPE, UCP1, UCP2
21alpha msh4411.1AGRP, LEP, MC3R, MC4R
22troglitazone44 28 59 1114.1PPARG, UCP2, FABP4, LEP, UCP3
23intralipid4411.1UCP3, CCKAR, PYY, LEP
24carbohydrates4411.1PYY, LEP, CCKAR, UCP2, FABP2
25isoproterenol44 1112.1PYY, UCP2, PLIN1, ADRB3, LIPE
26acth4411.1PYY, LEP, MC3R, MC4R, AGRP
27alanine4411.1FABP2, CCKAR, ADRB3, UCP2, PPARG, MC4R
28bezafibrate44 28 1113.1UCP2, UCP3, PPARG, UCP1
29fenofibrate44 49 1113.0LEP, UCP2, FABP2, PPARG
30shu 911944 5912.0MC4R, LEP, MC3R
31c-peptide4411.0LEP, PYY, ADRB3, UCP1
32pioglitazone44 49 28 1114.0LEP, FABP4, PPARG, NAMPT
33stearic acid44 11 2413.0PPARG, FABP4, FABP2, LIPE
34stavudine44 1112.0UCP1, LEP, PPARG
35ribonucleic acid4411.0UCP3, LIPE, NAMPT, UCP2, UCP1
36triiodothyronine4411.0UCP2, UCP1, UCP3, LEP
37carbacyclin44 2812.0PPARG, UCP2, UCP3
38palmitic acid28 11 2412.9LIPE, PPARG, FABP4, FABP2
39acipimox44 2811.9LIPE, LEP, UCP3
40oxyntomodulin44 5911.9AGRP, PYY, LEP
41linoleic acid44 28 2412.9PPARG, FABP2, UCP2, UCP1
42orlistat44 59 1112.8PYY, PPARG, LEP
43[125i]shu91192810.8MC4R, MC3R
44agouti-related protein2810.7MC4R, MC3R
45pg-9012810.7MC4R, MC3R
46hs0142810.6MC4R, MC3R
47niacin44 1111.6PPARG, NAMPT, LIPE
48carboxylate4410.6FABP2, FABP4, UCP1
49glycogen44 2411.6FABP2, UCP2, ADRB3, LIPE, UCP3
50thyroxine44 2411.4LEP, PPARG, UCP1, UCP2

GO Terms for genes affiliated with Morbid Obesity

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Sources:
16Gene Ontology
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Cellular components related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid particleGO:00581110.6PLIN1, LIPE, FABP4

Biological processes related to Morbid Obesity according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:05087311.0ADRB3, PPARG, FABP4, UCP1
2feeding behaviorGO:00763111.0MC4R, AGRP, CCKAR, PYY
3small molecule metabolic processGO:04428111.0UCP2, UCP1, UCP3, FABP4, LIPE, NAMPT
4mitochondrial transportGO:00683911.0UCP2, UCP1, UCP3
5eating behaviorGO:04275511.0ADRB3, LEP, PYY
6triglyceride catabolic processGO:01943311.0PLIN1, LIPE, FABP4
7proton transportGO:01599210.9UCP2, UCP1, UCP3
8response to coldGO:00940910.9ADRB3, PPARG, UCP3
9adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.9ADRB3, MC3R, MC4R
10response to insulin stimulusGO:03286810.9UCP3, MC4R, LEP
11regulation of blood pressureGO:00821710.9PPARG, MC3R, LEP
12digestionGO:00758610.9FABP2, CCKAR, PYY
13response to superoxideGO:00030310.9UCP3, UCP2
14response to nutrientGO:00758410.8PPARG, UCP3, CCKAR
15diet induced thermogenesisGO:00202410.8ADRB3, MC4R
16adult feeding behaviorGO:00834310.8LEP, AGRP
17respiratory electron transport chainGO:02290410.7UCP2, UCP1, UCP3
18white fat cell differentiationGO:05087210.7FABP4, PPARG
19energy reserve metabolic processGO:00611210.7ADRB3, LEP, MC4R
20cellular metabolic processGO:04423710.6UCP3, UCP1, UCP2
21cellular response to lithium ionGO:07128510.6PPARG, FABP4
22lipid metabolic processGO:00662910.5UCP3, PPARG, PLIN1
23adipose tissue developmentGO:06061210.3LEP, NAMPT

Molecular functions related to Morbid Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.6UCP3, UCP1
2melanocyte-stimulating hormone receptor activityGO:00498010.6MC3R, MC4R
3fatty acid bindingGO:00550410.6FABP4, FABP2
4melanocortin receptor activityGO:00497710.5MC4R, MC3R
5neuropeptide bindingGO:04292310.3MC3R, MC4R

Products for genes affiliated with Morbid Obesity

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  • Antibodies
  • Proteins
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Sources for Morbid Obesity

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet