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MCID: MRB003

Morbid Obesity malady
22 drugs, 165 genes, 12 tissues, 1033 related diseases, 25 phenotypes, 224 articles, clinical trials.

Summaries for Morbid Obesity

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33OMIM, 22MalaCards
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MalaCards: Morbid Obesity, also known as morbid obesity (disorder), is related to obesity and polycystic ovary syndrome. An important gene associated with Morbid Obesity is LEP (leptin), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Adenylate cyclase-activating neuropeptides. The drugs mazindol and phentermine and the compounds glucose and carbachol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and skeletal muscle, and related mouse phenotypes are hematopoietic system and respiratory system.

OMIM: 601665

Aliases & Descriptions for Morbid Obesity

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6Disease Ontology, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
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Aliases & Descriptions:

morbid obesity 6 8
morbid obesity (disorder) 6
obesity, severe 33
obesity, morbid 43
severe obesity 6
obesity morbid 32
obesity 43

External Ids:

ICD9CM19 278.01

Related Diseases for Morbid Obesity

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13GeneCards, 14GeneDecks
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Diseases related to morbid obesity by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1030)
idRelated DiseaseScoreTop Affiliating Genes
1obesity40.0UCP1, ENPP1, GHRL, ADRB2, ADRB3
2polycystic ovary syndrome35.6LEP, IRS1, INS, IGFBP1, IGF1, GH1
3insulin resistance35.0LEPR, UCP2, IRS1, INS, PTPN1, PPARGC1B
4sleep apnea33.7RETN, LEP, LSL, HCRT, NPPB, NPY
5glucose intolerance32.9GCG, MLN, APOA4, APOB, CCK, GHRL
6eating disorder32.8RETN, CNR1, LEP, LEPR, MC4R, CCK
7gestational diabetes32.8RETN, GCG, RBP4, NAMPT, LEP, LEPR
8fatty liver disease32.3CYP2E1, PPARA, SLC17A5, ADIPOQ
9alcoholism31.7CNR1, IL1RN, CCKBR, CCK, CCKAR, GPT
10bulimia nervosa30.7MC4R, CCK, GHRL
11gallbladder disease30.6MLN, CCKBR, CCK, CCKAR, PYY
12obesity, variation in30.3UCP2, UCP3, PPARGC1B, PPARG, ADRB2, ADRB3
13hyperandrogenism30.2REN, RETN, NAMPT, LEP, IRS1, INS
14cushing's syndrome30.2REN, RETN, LPL, BGLAP, LEP, INS
15type 2 diabetes mellitus30.1PIK3R1, RETN, CNR1, PCSK1, GCG, RBP4
16leptin deficiency30.1LEP, LEPR, IL18, CCK, GH1, PPARG
17prader-willi syndrome29.8RETN, GCG, LEP, LEPR, INS, IL18
18hepatitis29.4RBP4, GPT, F2, ALB, TNFRSF1A, CYP2E1
19hyperinsulinism29.2RETN, GCG, SELE, SERPINE1, LPL, VCAM1
20attention deficit hyperactivity disorder29.1LPL, ISL1, IL1RN, MC4R, TTF2, TF
21craniopharyngioma29.0LEP, INS, IL1A, IL6, IGF1, GH1
22laron syndrome28.9INS, IGFBP1, IGF1, GH1, LSL, ADIPOQ
23portal vein thrombosis28.9REN, SERPINE1, F5, F2, ALB, CRP
24metabolic syndrome x28.8SERPINE1, LPL, LEP, INS, IL6, IGFBP1
25hypothyroidism28.7RETN, LEP, CETP, APOB, GHRL, SHBG
26acanthosis nigricans28.6LEP, INS, IGF1, GH1, SHBG, SLC2A4
2721-hydroxylase deficiency28.5REN, MC2R, CYP19A1, NR3C1, LSL, POMC
28hypopituitarism28.3GCG, LEP, INS, IL6, IGF1, HSD11B1
29hypogonadotropism28.3PCSK1, BGLAP, LEP, LEPR, INS, F5
30diabetes, type 228.2GCG, SELE, INS, IL18, ALB, PPARG
31rheumatoid arthritis28.2IL1R1, IL1RN, MBL2, TNFRSF1A, CRP
32pulmonary embolism28.1PIK3C2A, SERPINE1, INS, F5, F2, ALB
33venous thrombosis28.0SERPINE1, CETP, ITGAM, APOB, F5, F2
34familial combined hyperlipidemia27.9LPL, LIPE, LIPC, LEPR, CETP, INS
35sleep disorder27.9VCAM1, LEP, INS, IL1R1, IL6, ALB
36hepatitis c27.8LIPC, IL18, GPT, IFNG, IDO1, F2
37hypogonadism27.7RETN, PCSK1, SERPINE1, LIPC, BGLAP, LEP
38pseudohypoparathyroidism27.5REN, BGLAP, IGF1, HP, GH1, PTH
39type 1 diabetes mellitus27.4RETN, GCG, RBP4, LIPC, BGLAP, LEP
40narcolepsy27.3VEGFA, SCARB1, LEP, INS, IL1A, IL1RN
41immunodeficiency27.3SELL, BPI, BMP6, MIF, INS, IL18
42hypertriglyceridemia27.2RBP4, SELE, SERPINE1, NAMPT, LPL, VCAM1
43nutritional deficiency disease27.2LEP, GHRL, TTR, TF
44overnutrition27.2LEP, FTO, INS, AKT1, AGRP
45apnea27.2REN, RETN, RBP4, SELE, SERPINE1, NAMPT
46hyperproinsulinemia27.1PCSK1, INS, IGFBP1, SHBG
47lymphopenia27.0SELL, INS, IL18, IL1RN, IL6, IFNG
48adrenal hyperplasia27.0REN, GCG, LEP, INS, MC2R, IGF1
49familial partial lipodystrophy26.8RETN, LEP, INS, TNF, PPARGC1A, PPARG
50was-related disorders26.8REN, CNR1, LPL, LIPC, LEP, CETP

Graphical network of the top 20 diseases related to morbid obesity:



Graphical network of diseases related to morbid obesity

Clinical Features for Morbid Obesity

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33OMIM
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Clinical features from OMIM: 601665

Drugs & Therapeutics for Morbid Obesity

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for morbid obesity

Drug clinical trials:

Search ClinicalTrials for morbid obesity

Search NIH Clinical Center for morbid obesity

Search CenterWatch for morbid obesity

Inferred drug relations via UMLS/NDF-RT:

43 28 benzphetamine, benzphetamine hydrochloride, dexfenfluramine, dexfenfluramine hydrochloride, diethylpropion, diethylpropion hydrochloride, fenfluramine, fenfluramine hydrochloride, mazindol, orlistat, phendimetrazine, phendimetrazine hydrochloride, phendimetrazine tartrate, phenmetrazine, phenmetrazine hydrochloride, phentermine, phentermine hydrochloride, phentermine resin complex, phenylpropanolamine, phenylpropanolamine hydrochloride, sibutramine, sibutramine hydrochloride

Genetic Tests for Morbid Obesity

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Anatomical Context for Morbid Obesity

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22MalaCards
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MalaCards organs/tissues related to morbid obesity:

22
Whole blood, Brain, Skeletal muscle, Adipocyte, Liver, Thyroid, Monocytes, T cells, B cells, Endothelial, Pancreatic islet, Pituitary

Phenotypes for genes affiliated with Morbid Obesity

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25MGI
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MGI Mouse Phenotypes related to morbid obesity:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.7PCSK1, MIF, AQP9, IDO1, PTH, SIM1
2respiratory system phenotypeMP:000538810.3SELL, LPL, LEPR, UCP2, PPARGC1B, PPARGC1A
3endocrine/exocrine gland phenotypeMP:000537910.1SH2B1, PCSK1, SELL, UGDH, AQP7, MC2R
4embryogenesis phenotypeMP:000538010.0SCARB1, UGDH, ISL1, MFN2, APLN, F2
5renal/urinary system phenotypeMP:00053679.9REN, LEPR, FTO, INS, FABP2, CCKBR
6limbs/digits/tail phenotypeMP:00053719.8VEGFA, SCD, LEP, CD44, ISL1, IRS1
7no phenotypic analysisMP:00030129.2PIK3R1, CNR1, VEGFA, VCAM1, LEPR, CD44
8integument phenotypeMP:00107718.6CNR1, LIPE, SCD, LEPR, CD44, ISL1
9skeleton phenotypeMP:00053907.8CNR1, VEGFA, BMP6, LEP, LEPR, CD44
10digestive/alimentary phenotypeMP:00053817.8PCSK1, GCG, VEGFA, LIPE, LEP, LEPR
11liver/biliary system phenotypeMP:00053707.7RETN, VEGFA, LPL, LIPE, SCD, IRS1
12immune system phenotypeMP:00053877.6SH2B1, REN, PCSK1, SELL, PAX5, SCARB1
13nervous system phenotypeMP:00036317.3REN, CNR1, VDAC1, PAX5, CD44, ITGAM
14reproductive system phenotypeMP:00053896.9SH2B1, REN, PCSK1, RBP4, VEGFA, LIPE
15vision/eye phenotypeMP:00053916.6RBP4, SELE, VEGFA, LEP, LEPR, UGDH
16growth/size phenotypeMP:00053786.6PIK3R1, PIK3C2A, SH2B1, REN, CNR1, PCSK1
17normal phenotypeMP:00028736.4PIK3R1, REN, RBP4, SELE, VEGFA, PAX5
18adipose tissue phenotypeMP:00053756.3PIK3R1, PIK3C2A, RETN, CNR1, PCSK1, SERPINE1
19muscle phenotypeMP:00053695.8PIK3R1, REN, PCSK1, RBP4, VEGFA, LPL
20behavior/neurological phenotypeMP:00053865.5REN, CNR1, PCSK1, SELE, VEGFA, VDAC1
21tumorigenesisMP:00020065.2PIK3R1, SELL, SERPINE1, LEP, LEPR, CD44
22mortality/agingMP:00107685.0PIK3C2A, SH2B1, REN, CNR1, PCSK1, GCG
23cellular phenotypeMP:00053844.3PIK3R1, CNR1, PCSK1, RBP4, SELE, SELL
24homeostasis/metabolism phenotypeMP:00053763.8PIK3R1, PIK3C2A, SH2B1, REN, RETN, CNR1
25cardiovascular system phenotypeMP:00053851.9PIK3R1, REN, PCSK1, RBP4, SELE, SELL

Publications for genes affiliated with Morbid Obesity

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35PubMed
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Articles related to morbid obesity:

(show top 50)    (show all 224)
idTitleAuthorsYearAffiliating Genes
1GLUT2 accumulation in enterocyte apical and intracell ular membranes: a study in morbidly obese human subjects and ob/ob and high fat -fed mice. (21852673)Ait-Omar A.... Brot-Laroche E.2011SLC2A2
2Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects. (21060977)GarcA-a-Serrano S.... GarcA-a-Fuentes E.2011SCD
3Retinol and alpha-tocopherol in morbid obesity and no nalcoholic fatty liver disease. (18830789)Botella-Carretero J.I.... Escobar-Morreale H.F.2010GPT, SLC17A5
4Elevated Fetuin-A concentrations in morbid obesity de crease after dramatic weight loss. (20660040)Brix J.M.... Schernthaner G.2010AHSG
5Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic dis orders in morbidly obese patients. (19690925)Baudrand R.... Fardella C.E.2010HSD11B1
6Dysregulation of gene expression within the peroxisom e proliferator activated receptor pathway in morbidly obese patients. (18855061)Hindle A.K.... Brody F.2009PPARG
7Inflammatory mediators in morbidly obese subjects: as sociations with glucose abnormalities and changes after oral glucose. (19542241)HofsA... Hjelmesaeth J.2009IL1R1, TNFRSF11B, CRP
8Impact of laparoscopic Roux-en-Y gastric bypass on me tabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women. (19018603)Iannelli A.... Gugenheim J.2009INS
9Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormali ties. (19615702)Miranda M.... Vendrell J.2009AQP7, AQP9
10YKL-40 is elevated in morbidly obese patients and dec lines after weight loss. (19633900)Hempen M.... Schernthaner G.H.2009CCL2
11G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patient s with morbid obesity (20049372)Luis D.A.... Romero E.2009CNR1
12Effects of weight loss on lipid transfer proteins in morbidly obese women. (19789902)Laimer M.W.... Ebenbichler C.F.2009LPL, PLTP, LIPC
13RIP140 Gene and Protein Expression Levels are Downregulated in Visceral Adipose Tissue in Human Morbid Obesity. (19367438)CatalA!n V.... FrA1hbeck G.2009NRIP1
14Hepatic gene expression in morbidly obese women: impl ications for disease susceptibility. (19265796)Elam M.B.... Raghow R.2009LEPR, IGFBP1
15Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. (18952835)Bertola A.... Gual P.2009SPP1, CD44
16Analysis of the results of sleeve gastrectomy for morbid obesity and the role of ghrelin. (18516524)Frezza E.E.... Wachtel M.S.2008GHRL
17Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. (18231126)Mencarelli M.... Di Blasio A.M.2008MC3R
18Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. (18175194)Goldner W.S.... McBride C.2008ALB
19Relation of Trp64Arg polymorphism of beta3-adrenoreceptor gene with cardiovascular risk factors in presurgical morbidly obese patients. (18996293)de Luis D.A.... Conde R.2008ADRB3
20Neuroendocrine bases in the surgical treatment of the morbid obesity: two cases operated with the technique of Santoro, in the HERM (19156184)RA-os CanturA-n P.J.... RA-os Torres P.O.2008PYY
21Further Evidence For the Role of ENPP1 in Obesity: Association With Morbid Obesity in Finns. (18551113)Valli-Jaakola K.... Kontula K.2008POMC, ENPP1, MC2R
22Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients. (17287921)Brody F.... Fu S.2007PPARG, ENPP1
23Correlation between insulin resistance surrogates and echocardiographic findings in asymptomatic patients with morbid obesity: a cross-sectional study. (17954414)Ybarra J.... Navarro-LA^pez F.2007ADIPOQ, INS
24Growth hormone status in morbidly obese subjects and correlation with body composition. (16840832)Savastano S.... Colao A.2006UGDH
25Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients. (16687019)Brandacher G.... Weiss H.G.2006IFNG, IDO1
26Soluble CD40L in patients with morbid obesity: significant reduction after bariatric surgery. (16684123)Schernthaner G.H.... Schernthaner G.2006CCL2, INS
27Thyroid function in humans with morbid obesity. (16487017)Michalaki M.A.... Kyriazopoulou V.E.2006LSL
28Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity. (15919838)Li H.Y.... Chuang L.M.2005AOC3
29Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women. (16117191)Savastano S.... Colao A.2005INS
30Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. (15830179)Vasseur F.... Froguel P.2005ADIPOQ
31Carbohydrate metabolism derangements in patients with morbid obesity: weight loss impact (15811276)SolA! Izquierdo E.... HernA!ndez Mijares A.2005INS
32Calcium metabolism in the morbidly obese. (14980026)Hamoui N.... Crookes P.F.2004ALB
33Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. (14764818)Valli-Jaakola K.... Schalin-Jaentti C.2004MC4R
34Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. (15235769)Kipfer-Coudreau S.... Clement K.2004PTPN1
35Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. (15130222)Nijhuis J.... Greve J.W.2004LEP
36The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. (15186624)Cottam D.R.... Schauer P.R.2004TNF, BMP6
37Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. (12679444)Faraj M.... Cianflone K.2003C3, ADIPOQ, APOB
38The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity. (12822042)Sykiotis G.P.... Flordellis C.S.2003ADRB2, ADRA2B
39Gastric pacing for morbid obesity: plasma levels of gastrointestinal peptides and leptin. (14694209)Cigaina V.... Hirschberg A.L.2003LEP
40Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity. (12957694)Mingrone G.... Vidal H.2003INS
41Systemic inflammatory response after laparoscopic and open application of adjustable banding for morbidly obese patients. (11975228)Zengin K.... Uzun H.2002IL6, TF, CP
42Relationship between cholesteryl ester transfer protein and atherogenic lipoprotein profile in morbidly obese women. (12231567)Ebenbichler C.F.... Patsch J.R.2002CETP
43A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. (11443223)Mergen M.... Oner C.2001MC4R
44Leptin concentrations do not correlate with fat mass nor with metabolic risk factors in morbidly obese females. (11853365)GarcA-a-Lorda P.... Salas-SalvadA^ J.2001LEP
45Plasma levels of insulin and leptin in patients with morbid obesity and anorexia nervosa after weight loss or gain, respectively (11062083)Escobar L.... Aguilar M.2000LEP, INS, LSL
46Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. (10903341)Vaisse C.... Froguel P.2000MC4R, AGRP
47Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients. (9892245)Otabe S.... Vasseur F.1999UCP3
48A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q. (10334320)Clement K.... Froguel P.1999LPL, PPARG, LIPE
49Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity. (9222646)Roche C.... Froguel P.1997NPY, NPY1R, NPY5R
50Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans. (2166354)Martin L.F.... LaNoue K.F.1990ADCY10

Expression for genes affiliated with Morbid Obesity

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Morbid Obesity

Pathways for genes affiliated with Morbid Obesity

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38Reactome, 10EMD Millipore, 41Thomson Reuters, 20KEGG, 37R&D Systems, 36QIAGEN, 3Cell Signaling Technology, 34PharmGKB
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Pathways related to morbid obesity according to GeneDecks:

(show top 50)    (show all 97)
idPathwayScoreTop Affiliating Genes
1Class A/1 (Rhodopsin-like receptors)3811.0NPY5R, MC2R, MC4R, NPY1R, NPY, PPY
2Adenylate cyclase-activating neuropeptides1011.0GCG, MC5R, MC2R, MC3R, AGRP, GLP1R
3Development Beta-adrenergic receptors signaling via cAMP1010.8ADRB3, ADRB1, ADRB2, PLIN1, PPARG, PPARGC1A
4Development_Beta-adrenergic receptors signaling via cAMP4110.8LIPE, PPARGC1A, PPARG, PLIN1, ADRB1, ADRB3
5Development_Leptin signaling via JAK/STAT and MAPK cascades4110.8LEPR, PTPN1, SOCS3
6PPAR signaling pathway2010.7UCP1, SCD, LPL, AQP7, FABP4, FABP2
7Adipocytokines & Insulin Signaling3710.6PRKAA1, PIK3R1, RETN, RBP4, NAMPT, LEP
8Development Leptin signaling via JAK/STAT and MAPK cascades1010.6LEPR, PTPN1, CRP, POMC, SOCS3, LEP
9G alpha (q) signalling events3810.5CCKAR, NTS, HCRT, GAST, GHRL, CCK
10Type II diabetes mellitus2010.5SLC2A4, SOCS3, INS, IRS1, PIK3R1, SLC2A2
11Neuroactive ligand-receptor interaction2010.4MC3R, NPY5R, MC2R, GH1, GLP1R, F2
12Insulin signaling pathway2010.4SOCS3, LIPE, SLC2A4, PRKAA1, SREBF1, PTPN1
13Selected targets of C/EBPbeta1010.4SLC2A2, APOB, UCP3, RETN, CETP, FABP4
14AMPK Enzyme Complex Pathway3610.3AKT1, INS, ADRA2B, CPT2, SLC2A4, PIK3R1
15Glucose / Energy Metabolism310.3IRS1, PPARGC1A, PPARG, SCD, SREBF1, TBC1D1
16Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics3410.2SLC2A2, ABCC8, AKT1, PIK3R1, PIK3C2A, ISL1
17Selected targets of C/EBPalpha1010.2TF, FABP4, SLC2A2, RETN, ALB, APOB
18Development Leptin signaling via PI3K-dependent pathway1010.2AKT1, SLC2A4, ABCC8, IRS1, LEPR, PIK3R1
19Development_Leptin signaling via PI3K-dependent pathway4110.1AKT1, LEP, LEPR, IRS1, PIK3R1, SLC2A4
20Selected targets of HNF11010.1DPP4, IAPP, IGFBP1, APOB, INS, UCP2
21Statin Pathway, Pharmacodynamics349.8APOB, APOA4, SCARB1, LIPC, LPL, PLTP
22Transcription Receptor-mediated HIF regulation109.7HIF1A, IGF1, INS, IRS1, PIK3R1
23Metabolism of lipids and lipoproteins389.6LPL, GGT1, PLA2G2A, SREBF1, ALB, HSD11B1
24Selected targets of GCR-alpha109.5IGFBP1, AQP9, IL6, IL1B, INS, UCP3
25Adipocytokine signaling pathway209.4LEPR, IRS1, AKT1, TNF, PPARGC1A, PPARA
26PGC1Alpha Pathway369.3PPARA, PPARGC1A, TNFRSF1A, BMP6, IL18, IL1A
27Akt Signaling369.3PIK3R1, IL6, IL18, IRS1, CCL2, AKT1
28Transcription_Receptor-mediated HIF regulation419.0VEGFA, HIF1A, INS, IGF1, IRS1, AKT1
29Immune response MIF-mediated glucocorticoid regulation109.0VCAM1, MIF, IL6, NR3C1, IFNG, TNF
30PPAR Pathway369.0PPARA, TNFRSF1A, IGF1, GH1, PPARG, PIK3R1
31IL-10 Pathway368.8SOCS3, PIK3R1, STAT3, IL6, TNF, IL1B
32MIF Mediated Glucocorticoid Regulation368.7IL1B, IL1A, IL18, BMP6, IL6, CCL2
33African trypanosomiasis208.6IL18, IL1B, IL6, IFNG, IDO1, TNF
34HMGB1 Pathway368.5IL1A, IL1B, IL1R1, IFNG, AKT1, TNF
35Influenza A208.4TNF, TNFRSF1A, SOCS3, IL1A, IFNG, CCL2
36Tec Kinases Signaling368.2GH1, IL18, PIK3R1, STAT3, ITGAM, IL6
37MSP-RON Signaling368.2TNF, IL1B, CCL2, PIK3R1, IFNG, ITGAM
38Signaling Involved in Cardiac Hypertrophy368.2AKT1, IL6, GATA4, ADRA2B, STAT3, TGFB1
39Osteoclast differentiation207.9IL1A, PIK3R1, AKT1, IL1B, IFNG, TGFB1
40Malaria207.9IL6, SELE, VCAM1, IL1B, IFNG, TNF
41Tuberculosis207.9TNF, IL1A, IL6, IL1B, IL18, ITGAM
42Transcription_Role of VDR in regulation of genes involved in osteoporosis417.8IL6, IL1B, IL1A, BGLAP, THRA, IGF1
43Transcription Role of VDR in regulation of genes involved in osteoporosis107.8IFNG, NR3C1, TNF, TNFRSF11B, THRA, CYP19A1
44NF-KappaB (p50-p65) Pathway367.7TGFB1, TNFRSF1A, TNF, AKT1, IL6, BMP6
45NF-KappaB Family Pathway367.6IL1B, IL1A, BMP6, PIK3R1, IL1R1, IL6
46TGF-Beta Pathway367.6CCL2, IL18, BMP6, PIK3R1, IL1A, IL1R1
47Rheumatoid arthritis207.5CCL2, TGFB1, TNF, IFNG, IL6, IL1B
48Chagas disease (American trypanosomiasis)207.3C3, AKT1, IL6, IL1B, ACE, TNFRSF1A
49Cytokine-cytokine receptor interaction207.2IL18, VEGFA, LEP, CCL2, IL6, IL1R1
50JAK-STAT Pathway366.5IFNG, F2, AKT1, GH1, TNFRSF1A, TGFB1

Compounds for genes affiliated with Morbid Obesity

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to morbid obesity according to GeneDecks:

(show top 50)    (show all 573)
idCompoundScoreTop Affiliating Genes
1glucose32 11.0PCSK1, GCG, UGDH, ISL1, MIF, MFN2
2carbachol32 9 9 12.5GCG, CCK, PTH, HCRT, NPPB, ADRB2
3pyruvate32 10.5PIK3C2A, VDAC1, LIPE, UCP1, UCP2, UCP3
4cyclic amp32 18 11.5PIK3R1, CNR1, GCG, LIPE, SCARB1, UCP1
5citrate32 10.5PIK3C2A, VDAC1, LIPE, UCP3, HP, SREBF1
6oxyntomodulin32 42 11.4PCSK1, GCG, LEP, MLN, CCK, GLP1R
7cholesterol ester32 9.9LIPE, LIPC, SCARB1, SCD, CETP, APOA4
8triacylglycerol32 9.8GCG, RBP4, SERPINE1, LPL, LIPE, LIPC
9sterol32 9.7PIK3R1, RETN, LIPE, LIPC, SCARB1, SCD
10potassium32 9 18 9 12.6PIK3C2A, REN, VDAC1, LEPR, UCP2, LCN1
11oxygen32 18 10.6PIK3C2A, RBP4, VDAC1, LIPE, LIPC, SCARB1
12gnrh32 9.6PCSK1, GCG, SELL, SERPINE1, LEP, LEPR
13acetaminophen32 34 9 18 9 13.5GCG, CCK, GPT, F5, IAPP, F2
14glycerol32 9 18 9 12.5PIK3C2A, GCG, LPL, VDAC1, LIPE, LIPC
15niacin32 9 9 11.4NAMPT, LPL, LIPE, SCARB1, CETP, INS
16triiodothyronine32 9.4PIK3C2A, RBP4, LIPC, LEP, LEPR, UCP1
17vitamin-e32 9.4PIK3C2A, RBP4, VCAM1, SCARB1, SCD, UCP2
18uric acid32 18 10.2PIK3C2A, RETN, RBP4, SERPINE1, LEP, LCN1
19glutamate32 9.2PIK3R1, CNR1, GCG, VDAC1, BMP6, LEP
20calcitriol32 42 9 18 9 13.1REN, BMP6, BGLAP, PAX5, CD44, ITGAM
21atp32 9.1PIK3R1, PIK3C2A, VDAC1, LIPC, SCARB1, SCD
22glycogen32 18 10.1PIK3R1, PIK3C2A, RETN, GCG, VDAC1, LIPE
23pioglitazone32 9 9 10.9RETN, GCG, RBP4, NAMPT, VEGFA, LPL
24tibolone32 8.9SELE, SERPINE1, BGLAP, LEP, APOB, CCL2
25calcium32 9 18 9 11.8PIK3C2A, REN, RETN, CNR1, PCSK1, RBP4
26cysteine32 8.6GCG, RBP4, VDAC1, BPI, BGLAP, LEPR
27corticosterone32 18 9.6CNR1, GCG, BGLAP, LEPR, MIF, IL1A
28heparin32 9 18 9 11.5PIK3C2A, GCG, SERPINE1, LPL, BPI, LIPC
29forskolin32 42 9 9 11.4PIK3R1, REN, RETN, PCSK1, GCG, BMP6
30homocysteine32 18 9.3PIK3C2A, RETN, SELE, SERPINE1, VCAM1, CETP
31phosphatidylcholine32 8.2CNR1, SELE, LPL, VDAC1, VCAM1, LIPE
32pdtc32 7.8SELE, VCAM1, IL18, IL1A, IL6, CCL2
33arachidonic acid32 9 18 9 10.8CNR1, LPL, VDAC1, LIPE, LIPC, SCARB1
34ribonucleic acid32 7.7PCSK1, RBP4, NAMPT, BMP6, LIPE, SCARB1
35rantes32 7.6SELE, SELL, VCAM1, BMP6, CD44, ITGAM
36fibrinogen32 7.6PIK3C2A, RETN, SELE, SERPINE1, NAMPT, VCAM1
37neopterin32 7.5IL18, IL1A, IL1B, IL1R1, IL1RN, IL6
38ibmx32 7.5PCSK1, GCG, LPL, VCAM1, SCD, IRS1
39arginine32 7.3PIK3C2A, REN, CNR1, PCSK1, GCG, LIPC
40troglitazone32 42 9 9 10.2SELE, SERPINE1, LPL, VCAM1, BMP6, SCD
41cyclosporin a32 42 8.2PIK3C2A, LPL, VDAC1, LIPC, BGLAP, LEP
42aspirin32 34 18 8.7CNR1, SELE, SELL, SERPINE1, BMP6, SCARB1
43methotrexate32 34 42 9 9 10.7PIK3C2A, SELE, SERPINE1, BMP6, LEP, IL18
44atorvastatin32 34 9 18 9 10.6PIK3C2A, RETN, SELE, SELL, SERPINE1, VEGFA
45alanine32 6.6PIK3C2A, RETN, CNR1, GCG, RBP4, SELE
46metformin32 34 9 9 9.5RETN, CNR1, GCG, SERPINE1, NAMPT, LPL
47simvastatin32 34 42 9 18 9 10.9PIK3C2A, RBP4, SELE, SELL, SERPINE1, VEGFA
48cholesterol32 9 18 9 8.8PIK3R1, PIK3C2A, REN, RETN, RBP4, SELE
49indomethacin32 9 9 7.2REN, CNR1, GCG, SELL, LPL, BMP6
50dexamethasone32 42 34 9 9 6.2PIK3R1, REN, RETN, RBP4, SELL, SERPINE1

GO Terms for genes affiliated with Morbid Obesity

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12Gene Ontology
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Cellular components related to morbid obesity according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.8TNF, TNFRSF1A, TSHR, NPY1R, NPY5R, SLC2A4
2secretory granuleGO:0301418.9POMC, TF, HCRT, PLA2G2A, GHRL, IL1B
3platelet alpha granule lumenGO:0310938.6ALDOA, ALB, F5, IGF1, VEGFA, SERPINE1
4cell surfaceGO:0099868.4AOC3, ENPP1, ALPP, TNF, TNFRSF1A, TGFB1
5plasma membraneGO:0058866.5TSHR, ACE, ABCC8, PTPN1, TNFRSF1A, TNF
6extracellular regionGO:0055764.3HAMP, GAST, ADIPOQ, RETN, IL1R1, IL37
7extracellular spaceGO:0056152.8MIF, INS, IL18, IL1A, IL1B, IL1RN

Biological processes related to morbid obesity according to GeneDecks:

(show top 50)    (show all 87)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763111.0GLP1R, PYY, CCKAR, CCKBR, AGRP, MC4R
2positive regulation of cAMP biosynthetic processGO:03081911.0GCG, MC3R, MC4R, MC5R, PTH, ADRB1
3brown fat cell differentiationGO:05087310.9UCP1, ADRB2, SLC2A4, ADIPOQ, PPARG, ADRB1
4energy reserve metabolic processGO:00611210.8FASN, LEPR, LEP, GCG, PCSK1, INS
5fatty acid oxidationGO:01939510.8PPARG, ADIPOR1, ADIPOQ, PRKAA1, PPARGC1A, ADIPOR2
6response to coldGO:00940910.8ADRB3, IL18, UCP3, ADRB1, ADRB2, THRA
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.8TSHR, NPY, CCL2, MC5R, NPY1R, MC2R
8hormone-mediated signaling pathwayGO:00975510.7ADIPOR1, REN, THRA, GHRL, AGRP, ADIPOR2
9diet induced thermogenesisGO:00202410.7MC4R, ADRB1, ADRB2, ADRB3
10response to insulin stimulusGO:03286810.6RBP4, LEP, UCP3, IRS1, INSIG2, MC4R
11eating behaviorGO:04275510.6PYY, ADRB3, CCK, HCRT, STAT3, NPY5R
12adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.5ADRB2, MC4R, MC3R, GCG, CNR1, ADRB3
13negative regulation of appetiteGO:03209910.4PPARA, CCK, LEP, GCG
14negative regulation of macrophage derived foam cell differentiationGO:01074510.4CETP, PPARG, CRP, ADIPOQ, PPARA
15G-protein coupled receptor signaling pathwayGO:00718610.4GCG, ADRA2B, INS, CCL2, AKT1, GHRL
16triglyceride catabolic processGO:01943310.3LPL, PLIN1, PNPLA3, FABP4, APOB, LIPC
17glucose metabolic processGO:00600610.3GAPDH, ADIPOQ, PRKAA1, TNF, GHRL, NPY1R
18cholesterol metabolic processGO:00820310.1APOB, LIPE, LIPC, LEP, LEPR, CETP
19cellular response to insulin stimulusGO:03286910.1AKT1, ENPP1, ADIPOQ, SLC2A4, HIF1A, PPARG
20positive regulation of glucose importGO:04632610.0PTH, AKT1, PIK3R1, INS, IGF1, ADIPOQ
21positive regulation of glycogen biosynthetic processGO:0457259.9AKT1, IGF1, INS, IRS1, PTH
22negative regulation of insulin receptor signaling pathwayGO:0466279.8AHSG, IRS1, SOCS3, PTPN1, ENPP1, IL1B
23response to activityGO:0148239.8BGLAP, UCP3, CCL2, TNF, NR3C1, PRKAA1
24lipid metabolic processGO:0066299.8PLIN1, LPL, CETP, IL1RN, APOA4, APOB
25acute-phase responseGO:0069539.8AHSG, INS, IL1RN, IL6, MBL2, STAT3
26glucose homeostasisGO:0425939.7SERPINE1, PPARG, HIF1A, AKT1, ADIPOQ, PRKAA1
27response to ethanolGO:0454719.7CNR1, ADIPOQ, SLC2A4, STAT3, TNFRSF1A, CCL2
28lipoprotein metabolic processGO:0421579.7APOA4, APOB, LPL, SCARB1, CETP, PPARA
29negative regulation of fat cell differentiationGO:0455999.7ADIPOQ, TNF, SIRT1, TGFB1, IL6, ENPP1
30cell-cell signalingGO:0072679.7PCSK1, MLN, INS, GATA4, ADRA2B, NAMPT
31organ regenerationGO:0311009.5AHSG, F7, PPARG, CCL2, CCKAR, SOCS3
32positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4GH1, VEGFA, CD44, INS, IL6, MIF
33response to glucocorticoid stimulusGO:0513849.2BGLAP, SERPINE1, PCSK1, CCL2, UCP3, IL1B
34negative regulation of apoptotic processGO:0430669.2ALB, GLP1R, AKT1, GHRL, TNF, PRKAA1
35regulation of insulin secretionGO:0507969.1ABCC8, TNF, IFNG, GLP1R, IL1B, SLC2A2
36positive regulation vascular endothelial growth factor productionGO:0105759.1ISL1, GATA4, IL1B, C3, TGFB1, HIF1A
37agingGO:0075689.1CCL2, CNR1, VCAM1, ADRB3, ADRB1, TGFB1
38positive regulation of peptidyl-serine phosphorylationGO:0331389.1GCG, VEGFA, CD44, MIF, IL6, AKT1
39positive regulation of angiogenesisGO:0457669.0SERPINE1, VEGFA, ISL1, IL1A, HIF1A, C3
40positive regulation of cell proliferationGO:0082848.9IL6, IRS1, CCKBR, INS, CCK, ADRB2
41lipopolysaccharide-mediated signaling pathwayGO:0316638.8SCARB1, TGFB1, IL18, IL1B, CCL2, TNF
42protein kinase B signaling cascadeGO:0434918.7IL1B, AKT1, TNF, CCL2, IRS1, TGFB1
43small molecule metabolic processGO:0442818.6ENPP1, SRD5A3, CYP19A1, CYP2E1, AKT1, AK1
44positive regulation of protein phosphorylationGO:0019348.2F2, AKT1, TNF, TGFB1, SIRT1, C3
45platelet activationGO:0301688.0AKT1, PTPN1, ALDOA, F2, TGFB1, TF
46inflammatory responseGO:0069547.9MIF, IL1B, IL1A, IL18, SELE, BMP6
47response to drugGO:0424937.9AQP7, IL1RN, BGLAP, LIPE, LPL, PCSK1
48blood coagulationGO:0075967.7ALDOA, SELL, SERPINE1, MFN2, VEGFA, ALB
49response to hypoxiaGO:0016667.7VEGFA, DPP4, HIF1A, TGFB1, PRKAA1, SOCS3
50positive regulation of transcription from RNA polymerase II promoterGO:0459445.9IL1B, IGF1, GATA4, ADRB2, SIRT1, PPARGC1A

Molecular functions related to morbid obesity according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1melanocortin receptor activityGO:00497710.8MC5R, MC4R, MC3R, MC2R
2neuropeptide hormone activityGO:00518410.6NPY, AGRP, HCRT, NTS, PYY, CCK
3epinephrine bindingGO:05137910.6ADRA2B, ADRB1, ADRB3, ADRB2
4protease bindingGO:00202010.0DPP4, TNFRSF1A, TNF, IL1R1, INS, SERPINE1
5insulin receptor bindingGO:00515810.0SLC2A2, PTPN1, IGF1, ENPP1, INS, IRS1
6hormone activityGO:0051799.8RETN, PTH, PPY, TTR, POMC, NPPB
7insulin-like growth factor receptor bindingGO:0051599.8IGF1, INS, IRS1, REN, PIK3R1
8copper ion bindingGO:0055079.8ALB, F5, AOC3, APOA4, IL1A, CP
9receptor bindingGO:0051029.5F2, PPY, AGRP, DPP4, POMC, NPPB
10drug bindingGO:0081449.5ADRB1, ADRB2, ACE, PPARA, PPARG, ALB
11interleukin-1 receptor bindingGO:0051499.4IL37, IL1RN, IL1B, IL1A
12cytokine activityGO:0051258.0IL6, IFNG, TNF, TNFRSF11B, SPP1, ADIPOQ
13growth factor activityGO:0080837.3TGFB1, GH1, F2, IGF1, IL6, IL1B
14protein bindingGO:0055154.2ACE, HIF1A, TTF2, TTR, TSHR, THRA

Sources for Morbid Obesity

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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