MCID: MRQ001
MIFTS: 24

Morquio Syndrome B malady

Summaries for Morquio Syndrome B

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Morquio Syndrome B, also known as mucopolysaccharidosis type ivb, is related to mucopolysaccharidosis and mucopolysaccharidosis iv. An important gene associated with Morquio Syndrome B is B3GAT3 (beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)), and among its related pathways are MPS IIIC - Sanfilippo syndrome C and Disease. The compounds chondroitin and n-acetylglucosamine have been mentioned in the context of this disorder.

Aliases & Classifications for Morquio Syndrome B

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Aliases & Descriptions:

morquio syndrome b 42
mucopolysaccharidosis type ivb 42 60
mps ivb 42
mps 4b 42


Related Diseases for Morquio Syndrome B

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Morquio Syndrome B family:

Morquio Syndrome C

Diseases related to Morquio Syndrome B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1mucopolysaccharidosis30.3SGSH, HYAL1
2mucopolysaccharidosis iv10.2
3mucopolysaccharidosis ix10.0HYAL1

Clinical Features for Morquio Syndrome B

About this section

Drugs & Therapeutics for Morquio Syndrome B

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Morquio Syndrome B

Drug clinical trials:

Search ClinicalTrials for Morquio Syndrome B

Search NIH Clinical Center for Morquio Syndrome B

Search CenterWatch for Morquio Syndrome B

Genetic Tests for Morquio Syndrome B

About this section

Anatomical Context for Morquio Syndrome B

About this section

Animal Models for Morquio Syndrome B or affiliated genes

About this section

Publications for Morquio Syndrome B

About this section

Genetic Variations for Morquio Syndrome B

About this section

Expression for genes affiliated with Morquio Syndrome B

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Morquio Syndrome B

Search GEO for disease gene expression data for Morquio Syndrome B.

Pathways for genes affiliated with Morquio Syndrome B

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
See all sources

Pathways related to Morquio Syndrome B according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7CHST2, CHST13, CHPF2, CHST14, CHST5, CHST7
210.7CSPG5, HAS3, KERA, CHST2, CHST13, CHPF2
3
Hide members
10.6HS3ST5, HS3ST6, NDST2, CSPG5, HAS3, KERA
4
Hide members
10.6CHST13, CHPF2, CHST14, CHST7, B3GALT6, B3GAT3
5
Hide members
10.6CSPG5, CHST2, CHST13, CHPF2, CHST14, CHST7
6
Hide members
10.6SGSH, GPC2, HS3ST5, HS3ST6, NDST2, CSPG5
7
Hide members
10.6B3GALT6, B3GNT4, B3GAT3, GPC2, HYAL1, HYAL2
8
Hide members
10.6HS3ST6, NDST2, CHST2, CHST13, CHST14, CHST5
9
Hide members
10.5KERA, CHST2, CHST5, OMD, B3GNT4
10
Hide members
10.5HS3ST5, NDST2, B3GALT6, B3GAT3
11
Hide members
10.5HYAL1, CHST14, CSPG5
1210.5HYAL1, HYAL2, SGSH
1310.5CHST7, CHST5, CHST2
14
Hide members
10.5HYAL2, HYAL1, HAS3

Compounds for genes affiliated with Morquio Syndrome B

About this section
Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Morquio Syndrome B according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chondroitin44 2411.7B3GAT3, B3GALT6, CHST7, CHST14, CHST13, CHST2
2n-acetylglucosamine4410.6HAS3, CHST2, CHST5, CHST7
3sulfate44 2411.5CHST2, CHST14, CHST5, CHST7
4heparan sulfate44 2411.5SGSH, B3GAT3, B3GALT6
5glycosaminoglycan4410.4SGSH, B3GAT3, HAS3
6hyaluronic acid44 2411.2HAS3, HYAL1, HYAL2

GO Terms for genes affiliated with Morquio Syndrome B

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Morquio Syndrome B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:00013910.8HYAL2, HS3ST5, HS3ST6, NDST2, CHST2, CHST13
2integral to membraneGO:01602110.7CHST2, HAS3, CSPG5, NDST2, HS3ST6, HS3ST5
3lysosomal lumenGO:04320210.7CSPG5, KERA, OMD, GPC2, HYAL1, SGSH
4Golgi lumenGO:00579610.5CSPG5, KERA, OMD, GPC2
5proteinaceous extracellular matrixGO:00557810.5GPC2, OMD, KERA
6hyaluranon cableGO:03611710.4HYAL1, HAS3
7intrinsic to Golgi membraneGO:03122810.2CHST5, CHST2

Biological processes related to Morquio Syndrome B according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.1CHST14, CHST5, CHST7, OMD, B3GALT6, B3GNT4
2glycosaminoglycan metabolic processGO:03020311.1HS3ST5, HS3ST6, NDST2, CSPG5, HAS3, KERA
3carbohydrate metabolic processGO:00597511.1SGSH, HAS3, KERA, CHST2, CHST13, CHPF2
4chondroitin sulfate metabolic processGO:03020411.0CSPG5, CHST13, CHPF2, CHST14, CHST7, B3GALT6
5glycosaminoglycan biosynthetic processGO:00602410.9HS3ST5, HS3ST6, NDST2, B3GALT6, B3GAT3, GPC2
6keratan sulfate biosynthetic processGO:01814610.9KERA, CHST2, CHST5, OMD, B3GNT4
7chondroitin sulfate biosynthetic processGO:03020610.9CSPG5, CHST13, CHPF2, CHST7, B3GALT6
8keratan sulfate metabolic processGO:04233910.9B3GNT4, OMD, CHST5, CHST2, KERA
9sulfur compound metabolic processGO:00679010.8CHST2, CHST5, CHST7
10heparan sulfate proteoglycan biosynthetic processGO:01501210.8NDST2, B3GALT6, B3GAT3
11N-acetylglucosamine metabolic processGO:00604410.8CHST7, CHST5, CHST2
12hyaluronan metabolic processGO:03021210.8HYAL2, HYAL1, HAS3
13glycosaminoglycan catabolic processGO:00602710.8GPC2, HYAL2, SGSH
14positive regulation of hyaluranon cable assemblyGO:190010610.8HYAL1, HAS3
15cellular response to UV-BGO:07149310.8HYAL1, HYAL2
16protein sulfationGO:00647710.7HS3ST5, CHST5
17hyaluronan biosynthetic processGO:03021310.7HYAL1, HAS3
18carbohydrate biosynthetic processGO:01605110.7CHST13, CHST14
19response to reactive oxygen speciesGO:00030210.7HYAL1, HYAL2
20dermatan sulfate biosynthetic processGO:03020810.7CHST14, CSPG5
21keratan sulfate catabolic processGO:04234010.6KERA, OMD
22chondroitin sulfate catabolic processGO:03020710.6HYAL1, CSPG5
23hyaluronan catabolic processGO:03021410.5HYAL2, HYAL1
24cellular response to interleukin-1GO:07134710.5HYAL2, HYAL1
25cellular response to fibroblast growth factor stimulusGO:04434410.4HYAL1, HYAL2
26response to antibioticGO:04667710.2HYAL2, HYAL1

Molecular functions related to Morquio Syndrome B according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1N-acetylglucosamine 6-O-sulfotransferase activityGO:00151710.7CHST7, CHST5, CHST2
2hyaluronan synthase activityGO:05050110.6HYAL1, HAS3
3[heparan sulfate]-glucosamine 3-sulfotransferase 1 activityGO:00846710.6HS3ST5, HS3ST6
4N-acetylgalactosamine 4-O-sulfotransferase activityGO:00153710.5CHST13, CHST14
5virus receptor activityGO:00161810.5HYAL2, HYAL1
6hyalurononglucosaminidase activityGO:00441510.4HYAL2, HYAL1
7sulfotransferase activityGO:00814610.2CHST5, CHST2

Products for genes affiliated with Morquio Syndrome B

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Morquio Syndrome B

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet