MCID: MRQ001
MIFTS: 20

Morquio Syndrome B malady

Rare diseases category

Summaries for Morquio Syndrome B

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34MalaCards
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MalaCards: Morquio Syndrome B, also known as mucopolysaccharidosis type ivb, is related to mucopolysaccharidosis and mucopolysaccharidosis iv. An important gene associated with Morquio Syndrome B is B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6), and among its related pathways are heparan sulfate biosynthesis and Dermatan sulfate biosynthesis. The compounds heparan sulfate and Poly-N-acetyllactosamine have been mentioned in the context of this disorder.

Aliases & Classifications for Morquio Syndrome B

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

morquio syndrome b 44
mucopolysaccharidosis type ivb 44 63
mps ivb 44
mps 4b 44


Related Diseases for Morquio Syndrome B

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18GeneCards, 19GeneDecks
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Diseases in the Morquio Syndrome B family:

Morquio Syndrome C

Diseases related to Morquio Syndrome B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1mucopolysaccharidosis10.3
2mucopolysaccharidosis iv10.2

Symptoms for Morquio Syndrome B

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Drugs & Therapeutics for Morquio Syndrome B

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Morquio Syndrome B

Drug clinical trials:

Search ClinicalTrials for Morquio Syndrome B

Search NIH Clinical Center for Morquio Syndrome B

Search CenterWatch for Morquio Syndrome B

Genetic Tests for Morquio Syndrome B

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Anatomical Context for Morquio Syndrome B

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Animal Models for Morquio Syndrome B or affiliated genes

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Publications for Morquio Syndrome B

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Variations for Morquio Syndrome B

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Expression for genes affiliated with Morquio Syndrome B

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Morquio Syndrome B

Search GEO for disease gene expression data for Morquio Syndrome B.

Pathways for genes affiliated with Morquio Syndrome B

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 52PharmGKB, 61Thomson Reuters
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Pathways related to Morquio Syndrome B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
heparan sulfate biosynthesis (late stages)39
9.8B3GALT6, B3GAT3
2
Show member pathways
chondroitin and dermatan biosynthesis39
dermatan sulfate biosynthesis39
glycoaminoglycan-protein linkage region biosynthesis39
dermatan sulfate biosynthesis (late stages)39
9.4CHPF2, CHST14, B3GAT3
3
Show member pathways
8.8HS3ST6, CHST5, CHST14, SLC26A1
4
Show member pathways
8.5CHST5, GLB1L, B3GNT4, KERA
5
Show member pathways
8.3B3GAT3, CHPF2, CHST14, GPC2, B3GALT6
6
Show member pathways
7.9HS3ST6, GLB1L, B3GAT3, B3GALT6, GPC2
75.5GPC2, CHST5, SLC26A1, KERA, GLB1L, B3GNT4
8
Show member pathways
5.5GPC2, CHST5, CHST14, B3GAT3, B3GALT6, B3GNT4
9
Show member pathways
5.5GPC2, SLC26A1, KERA, GLB1L, B3GNT4, B3GALT6

Compounds for genes affiliated with Morquio Syndrome B

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46Novoseek, 25HMDB
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Compounds related to Morquio Syndrome B according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1heparan sulfate46 2510.8B3GAT3, B3GALT6
2Poly-N-acetyllactosamine259.7CHST5, B3GALT6
3chondroitin46 2510.7CHST14, B3GALT6, B3GAT3
4Uridine diphosphate glucuronic acid259.6B3GAT3, CHPF2
5Uridine 5'-diphosphate259.4B3GAT3, CHPF2
6sulfate46 2510.3SLC26A1, CHST14, CHST5

GO Terms for genes affiliated with Morquio Syndrome B

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17Gene Ontology
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Cellular components related to Morquio Syndrome B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi cisterna membraneGO:0325809.4B3GALT6, CHPF2
2Golgi lumenGO:0057969.3GPC2, KERA
3lysosomal lumenGO:0432029.2KERA, GPC2
4Golgi membraneGO:0001397.7B3GNT4, HS3ST6, CHST5, CHST14, CHPF2, B3GAT3
5integral component of membraneGO:0160217.3HS3ST6, CHST5, CHST14, CHPF2, B3GAT3, B3GALT6

Biological processes related to Morquio Syndrome B according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein glycosylationGO:0064869.8B3GALT6, B3GAT3
2heparan sulfate proteoglycan biosynthetic processGO:0150129.7B3GALT6, B3GAT3
3chondroitin sulfate biosynthetic processGO:0302069.4B3GALT6, CHPF2
4keratan sulfate biosynthetic processGO:0181469.2KERA, B3GNT4, CHST5
5keratan sulfate metabolic processGO:0423399.2CHST5, B3GNT4, KERA
6glycosaminoglycan biosynthetic processGO:0060248.6GPC2, HS3ST6, B3GAT3, B3GALT6
7chondroitin sulfate metabolic processGO:0302048.4GPC2, CHST14, CHPF2, B3GAT3, B3GALT6
8glycosaminoglycan metabolic processGO:0302036.3KERA, B3GNT4, B3GALT6, B3GAT3, CHPF2, CHST14
9small molecule metabolic processGO:0442816.3GPC2, HS3ST6, CHST5, CHST14, CHPF2, B3GAT3
10carbohydrate metabolic processGO:0059755.7SLC26A1, GPC2, KERA, GLB1L, B3GNT4, B3GALT6

Products for genes affiliated with Morquio Syndrome B

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Morquio Syndrome B

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet