MCID: MTN003
MIFTS: 50

Motion Sickness malady

Summaries for Motion Sickness

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards: Motion Sickness, also known as travel sickness, unspecified, is related to space motion sickness and syncope. An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and Regulation of Water Balance by Renal Aquaporins. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds repinotan and 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:64 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:47 158280

Aliases & Classifications for Motion Sickness

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 47OMIM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

motion sickness 8 10 34 61
travel sickness, unspecified 8
motion sickness nos 8
travel sickness 8


External Ids:

Disease Ontology8 DOID:2951
ICD9CM27 994.6
OMIM47 158280
NCIt40 C34824
MeSH35 D009041
ICD1025 T75.3

Related Diseases for Motion Sickness

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Motion Sickness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1space motion sickness31.6MMP11
2syncope10.2
3seasonal affective disorder10.1
4vestibular nystagmus10.1
5ataxia10.1
6headache10.1
7hypoxia10.1
8h. pylori infection10.1
9orthostatic intolerance10.1
10posterior fossa tumors10.1
11dyspepsia10.0HTR3A
12anxiety disorder10.0HTR3A
13meningitis10.0AVP
14ischemia10.0HTR1A
15prion disease10.0AVP
16chronic fatigue syndrome10.0HTR1A
17anorexia nervosa10.0HTR3A, HTR1A
18premature ejaculation10.0HTR1A
19obesity10.0ADRA2A, HTR1A
20social phobia10.0HTR3A, HTR1A
21irritable bowel syndrome10.0TAC1, HTR3A
22constipation10.0TAC1, HTR3A
23nephrogenic diabetes insipidus10.0AQP1, AVP
24amnestic disorder10.0HTR1A, HTR3A
25panic disorder10.0HTR3A, HTR1A
26hypertension10.0TAC1, AVP
27colon adenocarcinoma10.0FOS
28neuroleptic malignant syndrome10.0HTR1A
29generalized anxiety disorder10.0HTR3A, HTR1A
30gilles de la tourette syndrome10.0HTR1A, ADRA2A
31serotonin syndrome10.0TAC1, HTR1A, HTR3A
32sudden infant death syndrome10.0TAC1, HTR1A, HTR3A
33dopa-responsive cervical dystonia10.0HTR3A, TACR1, HTR1A
34cystitis10.0TACR1, TAC1
35fibromyalgia10.0HTR3A, TACR1, TAC1
36pancreatitis10.0TAC1, TACR1
37mood disorder10.0ADRA2A, HTR3A, HTR1A, TACR1
38colorectal cancer10.0FOS, MMP11, SAT1
39alzheimer's disease10.0TACR1, AQP1, HTR1A
40leukemia10.0HTR3A, SAT1, FOS
41parkinson's disease10.0HTR1A, FOS, TAC1
42adenocarcinoma10.0ADRA2A, AQP1, TAC1, TACR1, MMP11
43arthritis10.0TACR1, FOS, TAC1
44lung cancer10.0FOS, HTR1A, SAT1, MMP11
45colon cancer10.0FOS, HTR3A, TAC1, SAT1
46cholera10.0HTR3A, FOS, HTR1A, TAC1, ADRA2A
47glioblastoma multiforme10.0AQP1, TACR1, TAC1, FOS
48pain agnosia10.0HTR3A, TAC1, HTR1A, TACR1, FOS
49migraine10.0TACR1, TAC1, FOS, HTR3A, HTR1A
50astrocytoma10.0TACR1, AQP1, TAC1, FOS

Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Clinical Features for Motion Sickness

Sources:
47OMIM
See all sources

Clinical features from OMIM:

158280

Drugs & Therapeutics for Motion Sickness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Motion Sickness

Anatomical Context for Motion Sickness

Animal Models for Motion Sickness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Motion Sickness

Sources:
51PubMed
See all sources

Articles related to Motion Sickness:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Motion sickness induces intestinal transit increase in mice. (23206222)
2013
2
Self-adjustments may account for the contradictory correlations between HRV and motion-sickness severity. (23159509)
2013
3
Can passengers' active head tilt decrease the severity of carsickness? Effect of head tilt on severity of motion sickness in a lateral acceleration environment. (22624289)
2012
4
An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness. (22264564)
2012
5
FPIN's Clinical Inquiries. Treatment of motion sickness. (22962932)
2012
6
The effect of smoking nicotine tobacco versus smoking deprivation on motion sickness. (21036110)
2011
7
A rationale for space motion sickness. (21748915)
2011
8
Control of a virtual vehicle influences postural activity and motion sickness. (21604911)
2011
9
Controlling motion sickness and spatial disorientation and enhancing vestibular rehabilitation with a user-worn see-through display. (21181963)
2011
10
Motion sickness: comparison of metoclopramide and diphenhydramine to placebo. (22008228)
2011
11
Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia. (20360423)
2010
12
Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation. (19863229)
2009
13
Performance and autonomic responses during motion sickness. (19634309)
2009
14
Vestibular functions in motion sickness susceptible individuals. (19242710)
2009
15
Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats. (18471143)
2008
16
Vibrotactile stimulators and virtual 3-D audio countermeasures, training and motion sickness symptoms with a simulated graveyard spin illusion. (19542602)
2008
17
Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate. (17903249)
2007
18
Motion sickness, console video games, and head-mounted displays. (17915607)
2007
19
Labyrinthine lesions and motion sickness susceptibility. (17256169)
2007
20
Motion sickness, body movement, and claustrophobia during passive restraint. (17021895)
2007
21
Motion sickness provoked by torso rotation predicts that caused by head nodding. (16964739)
2006
22
Effects of ethnicity and gender on motion sickness susceptibility. (16313141)
2005
23
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. (15354005)
2004
24
Vector analysis of electrogastrography during motion sickness. (12757161)
2003
25
Correlation of phasic and tonic skin-conductance responses with severity of motion sickness induced by viewing an optokinetic rotating drum. (15002846)
2003
26
Experimentally induced motion sickness in fish: possible role of the otolith organs. (12797583)
2003
27
Failure of cetirizine and fexofenadine to prevent motion sickness. (12549941)
2003
28
Motion sickness and tilts of the inertial force environment: active suspension systems vs. active passengers. (12650268)
2003
29
Relationship between temporal changes in cardiac parasympathetic activity and motion sickness severity. (12751802)
2003
30
Reduction of motion sickness in prehospital trauma care. (12688274)
2003
31
Postural instability and motion sickness in a fixed-based flight simulator. (11132807)
2000
32
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness. (10597557)
1999
33
The retention of adaptation to motion sickness eliciting stimulation. (10447049)
1999
34
Gastrointestinal motor and myoelectric correlates of motion sickness. (10484390)
1999
35
Age differences in self-reported susceptibility to motion sickness. (10052078)
1998
36
Managing space motion sickness. (9416592)
1998
37
Frequency effect of 0.35-1.0 Hz horizontal translational oscillation on motion sickness and the somatogravic illusion. (9143749)
1997
38
Psychophysiological aspects of motion sickness. (9450266)
1997
39
Male/female differences in drug-induced emesis and motion sickness in Suncus murinus. (9258999)
1997
40
Objective and subjective time courses of recovery from motion sickness assessed by repeated motion challenges. (9397392)
1997
41
"Torso rotation" experiments; 2: Gaze stability during voluntary head movements improves with adaptation to motion sickness. (8887894)
1996
42
Space motion sickness. (7741942)
1995
43
Teleology of motion sickness. (7610787)
1995
44
Effects of phenytoin on vection-induced motion sickness and gastric myoelectric activity. (8074624)
1994
45
The influence of age on susceptibility to motion sickness in monkeys. (1342400)
1992
46
Why is the driver rarely motion sick? The role of controllability in motion sickness. (1915252)
1991
47
Catecholaminergic responses to rotational stress in rat brain stem: implications for amphetamine therapy of motion sickness. (2256874)
1990
48
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. (11537411)
1989
49
The use of the logistic model in space motion sickness prediction. (3675512)
1987
50
Carbonic anhydrase inhibitors for prevention of space motion sickness: an avenue of investigation. (6517821)
1984

Genetic Variations for Motion Sickness

Expression for genes affiliated with Motion Sickness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Motion Sickness

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1repinotan45 2911.3HTR1A, HTR3A
21-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide4510.3HTR3A, HTR1A
3tandospirone45 2911.3HTR1A, HTR3A
4phenylbiguanide4510.3HTR1A, HTR3A
5alpha-methylserotonin4510.3HTR3A, HTR1A
6zacopride45 2911.3HTR3A, HTR1A
7abecarnil4510.2HTR3A, HTR1A
8pizotifen45 2911.2HTR1A, HTR3A
9way 1006354510.2HTR1A, HTR3A
10(tfmpp)4510.2HTR1A, HTR3A
11dihydroergotamine29 45 1112.2ADRA2A, HTR3A, HTR1A
12amperozide4510.1HTR1A, HTR3A
13nefazodone45 50 1112.1HTR3A, ADRA2A, HTR1A
14mianserin29 45 1112.1ADRA2A, HTR3A, HTR1A
15ergotamine29 45 1112.1HTR1A, ADRA2A, HTR3A
16aripiprazole29 50 45 11 2414.1ADRA2A, HTR3A, HTR1A
17ziprasidone50 29 45 1113.1HTR3A, HTR1A, ADRA2A
18amitriptyline45 50 29 1113.0ADRA2A, HTR1A, HTR3A
19quetiapine45 50 29 11 2414.0HTR3A, ADRA2A, HTR1A
20yohimbine45 29 2 1112.9HTR1A, HTR3A, ADRA2A, TAS2R38
21quinuclidine459.8TACR1, HTR3A
22apomorphine45 29 1111.8ADRA2A, FOS, HTR1A
232-methyl-5-ht45 2910.8HTR1A, TACR1, HTR3A
24risperidone29 45 50 60 11 2414.7HTR3A, ADRA2A, HTR1A
25clomipramine45 50 1111.7HTR1A, TACR1, HTR3A
26paroxetine45 50 29 1112.7HTR1A, TACR1, HTR3A
27ly30387045 2910.7TACR1, TAC1
28rp6758045 2910.7TAC1, TACR1
29gr 71251459.7TAC1, TACR1
30cp 96345459.6TAC1, TACR1
31olanzapine50 45 29 11 2413.6HTR3A, HTR1A, FOS, ADRA2A
32chlorpromazine45 29 50 1112.6ADRA2A, HTR1A, HTR3A
33ezlopitant45 2910.6TACR1, TAC1
34palonosetron45 1110.5TACR1, TAC1, HTR3A
35aprepitant45 29 1111.5TACR1, TAC1, HTR3A
36physalaemin45 2910.5TACR1, TAC1
37scopolamine45 29 11 2412.4HTR1A, TACR1, TAC1
38gr 82334459.4TAC1, TACR1
39osanetant29 4510.4TACR1, TAC1
40ondansetron45 50 11 2412.3TACR1, HTR3A, TAC1, HTR1A
41fluoxetine50 45 29 1112.2HTR1A, TAC1, TACR1, HTR3A
425-hydroxytryptamine459.2TACR1, HTR1A, HTR3A, TAC1
43clozapine45 29 50 1112.0HTR1A, HTR3A, ADRA2A, TACR1, FOS
44citalopram50 45 11 2412.0HTR1A, HTR3A, TACR1
45chloride458.8TACR1, TAC1, AQP1, AVP
46norepinephrine45 11 2410.8TAC1, TACR1, AVP, ADRA2A, HTR1A, HTR3A
47haloperidol45 29 2 50 1112.7FOS, TACR1, TAC1, HTR3A, HTR1A
48dopamine45 29 11 2411.5TAC1, HTR3A, HTR1A, FOS, ADRA2A, TACR1
49adenylate458.5HTR1A, HTR3A, FOS, TACR1, ADRA2A, TAC1
50dexamethasone45 50 29 1111.4TACR1, AQP1, FOS, HTR3A, AVP, TAC1

GO Terms for genes affiliated with Motion Sickness

Sources:
16Gene Ontology
See all sources

Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.0AQP1, ADRA2A, PTPRM, TACR1, RNF43, HTR3A

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.3AQP1, AVP
2serotonin receptor signaling pathwayGO:00721010.2HTR3A, HTR1A
3vasoconstrictionGO:04231010.1HTR1A, AVP
4inseminationGO:00732010.0TAC1, SEMG1
5acute inflammatory responseGO:0025269.9ADRA2A, TACR1
6cellular response to hormone stimulusGO:0328709.7FOS, ADRA2A
7detection of abiotic stimulusGO:0095829.7TAC1, TACR1
8positive regulation of vasoconstrictionGO:0459079.7AVP, TACR1
9positive regulation of synaptic transmission, cholinergicGO:0322249.6TAC1, TACR1
10positive regulation of lymphocyte proliferationGO:0506719.6TAC1, TACR1
11positive regulation of action potentialGO:0457609.6TAC1, TACR1
12tachykinin receptor signaling pathwayGO:0072179.6TAC1, TACR1
13positive regulation of vasodilationGO:0459099.6ADRA2A, PTPRM
14positive regulation of synaptic transmission, GABAergicGO:0322309.6TAC1, TACR1
15positive regulation of renal sodium excretionGO:0358159.5TAC1, TACR1
16positive regulation of epithelial cell migrationGO:0106349.5TACR1, TAC1
17response to nicotineGO:0350949.5TACR1, AVP
18associative learningGO:0083069.4TACR1, TAC1
19positive regulation of saliva secretionGO:0468789.4TACR1, TAC1, AQP1
20response to morphineGO:0432789.3TAC1, TACR1
21elevation of cytosolic calcium ion concentrationGO:0072049.3TAC1, AVP, TACR1

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.8AQP1, HTR1A, FOS, PHLPP1, RNF43, TAC1

Products for genes affiliated with Motion Sickness

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Motion Sickness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet