MCID: MTN003
MIFTS: 47

Motion Sickness malady

Summaries for Motion Sickness

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MedlinePlus:32 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards based summary: Motion Sickness, also known as travel sickness, unspecified, is related to migraine and space motion sickness, and has symptoms including abnormality of the nervous system An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and SIDS Susceptibility Pathways. The drugs diphenhydramine hydrochloride and chlorcyclizine and the compounds repinotan and tandospirone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:63 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Aliases & Classifications for Motion Sickness

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Motion Sickness, Aliases & Descriptions:

Name: Motion Sickness 9 11 32 60
Travel Sickness, Unspecified 9
 
Motion Sickness Nos 9
Travel Sickness 9


Classifications:



External Ids:

Disease Ontology9 DOID:2951
NCIt38 C34824
ICD9CM27 994.6
MeSH33 D009041
ICD1025 T75.3

Related Diseases for Motion Sickness

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Diseases related to Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.1HTR1A, HTR3A
2space motion sickness11.1
3neuronitis10.5
4blindness10.4
5premature ejaculation10.4HTR1A
6neuroleptic malignant syndrome10.4HTR1A
7constipation10.3HTR3A
8irritable bowel syndrome10.3HTR3A
9yaws10.3
10syncope10.3
11gilles de la tourette syndrome10.2ADRA2A, HTR1A
12social phobia10.1HTR3A, HTR1A
13orthostatic intolerance10.1
14spinal cord injury10.1
15cervicitis10.1
16hyperglycemia10.1
17retinal degeneration10.1
18retinitis10.1
19mal de debarquement10.1
20ataxia10.1
21headache10.1
22hypoxia10.1
23amnestic disorder10.1HTR3A, HTR1A
24generalized anxiety disorder10.1HTR3A, HTR1A
25neurotic disorder10.1HTR1A, HTR3A
26serotonin syndrome10.1HTR3A, HTR1A
27obsessive-compulsive disorder10.1HTR3A, HTR1A
28eating disorder10.1HTR3A, HTR1A
29panic disorder10.1HTR1A, HTR3A
30anxiety disorder10.1HTR1A, HTR3A
31sudden infant death syndrome10.1HTR3A, HTR1A
32autistic disorder10.1HTR3A, HTR1A
33pain agnosia10.1HTR1A, HTR3A
34anorexia nervosa10.1HTR3A, HTR1A
35psychotic disorder10.0HTR1A, HTR3A
36alcohol dependence10.0HTR3A, HTR1A
37prion disease10.0HTR3A, HTR1A
38synovitis10.0MMP11, AQP1
39epilepsy syndrome10.0HTR3A, HTR1A
40bipolar disorder9.9HTR3A, HTR1A
41mood disorder9.9ADRA2A, HTR3A, HTR1A
42cholera9.9HTR3A, ADRA2A, HTR1A
43schizophrenia9.8ADRA2A, HTR3A, HTR1A
44dementia9.8HTR1A, HTR3A
45adenocarcinoma9.7ADRA2A, MMP11, AQP1
46malignant glioma9.6HTR3A, MMP11, AQP1, HTR1A

Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Symptoms for Motion Sickness

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HPO human phenotypes related to Motion Sickness:

id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707

Drugs & Therapeutics for Motion Sickness

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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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MalaCards organs/tissues related to Motion Sickness:

31
Eye, Brain, Heart, Testes, Skin, Cerebellum, Hypothalamus, Amygdala, Spinal cord

Animal Models for Motion Sickness or affiliated genes

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MGI Mouse Phenotypes related to Motion Sickness:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1HTR1A, HTR3A, ADRA2A, AQP1
2MP:00053858.0AQP1, MMP11, ADRA2A, HTR1A
3MP:00053867.8AQP1, ADRA2A, HTR3A, HTR1A
4MP:00053767.5HTR1A, HTR3A, ADRA2A, MMP11, AQP1

Publications for Motion Sickness

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Articles related to Motion Sickness:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Motion sickness prevalence in school children. (24893949)
2014
2
Brainstem processing of vestibular sensory exafference: implications for motion sickness etiology. (24838552)
2014
3
The comparison of sensitivity of motion sickness between retinal degeneration fast mice and normal mice. (24553916)
2014
4
Retraction note to: Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (23645569)
2013
5
EEG-based learning system for online motion sickness level estimation in a dynamic vehicle environment. (24808604)
2013
6
Motion sickness in rally car co-drivers. (23713212)
2013
7
Expression of calcitonin gene-related peptide in efferent vestibular system and vestibular nucleus in rats with motion sickness. (23056625)
2012
8
Pre-bout standing body sway differs between adult boxers who do and do not report post-bout motion sickness. (23056250)
2012
9
Migraine and motion sickness: what is the link? (20416353)
2010
10
Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation. (19863229)
2009
11
Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate. (17903249)
2007
12
Evaluation of adaptation to visually induced motion sickness by using physiological index associated with baroreflex function. (18001950)
2007
13
Motion sickness and migraine. (17445111)
2007
14
Rotation direction change hastens motion sickness onset in an optokinetic drum. (16676663)
2006
15
Space motion sickness: incidence, etiology, and countermeasures. (16935570)
2006
16
Sex differences in tolerance to visually-induced motion sickness. (16018346)
2005
17
Vertigo and motion sickness. Part I: vestibular anatomy and physiology. (16261758)
2005
18
Visual field effects on motion sickness in cars. (15460624)
2004
19
Vector analysis of electrogastrography during motion sickness. (12757161)
2003
20
Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. (11972579)
2002
21
Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness. (11911986)
2002
22
The correlation between aerobic fitness and motion sickness susceptibility. (11908888)
2002
23
Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats. (11132721)
2000
24
Postural instability and motion sickness in a fixed-based flight simulator. (11132807)
2000
25
Motion sickness occurrence does not correlate with nystagmus characteristics. (10841988)
2000
26
A comparison of motion sickness remedies in severe sea conditions. (10921365)
2000
27
Gender differences in motion sickness history and susceptibility to optokinetic rotation-induced motion sickness. (10608604)
1999
28
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness. (10597557)
1999
29
Keeping motion sickness at bay. (9708043)
1998
30
Postural instability precedes motion sickness. (10052572)
1998
31
Motion sickness susceptibility correlates with otolith- and canal-ocular reflexes. (9694209)
1998
32
Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. (10052582)
1998
33
Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (9260009)
1997
34
Optokinetic rotation-induced taste aversions correlate with over-all symptoms of motion sickness in humans. (8774022)
1996
35
The incidence and effects of motion sickness among medical attendants during transport. (7782619)
1995
36
Space motion sickness. (7741942)
1995
37
Motion Sickness. (9815382)
1995
38
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. (11537946)
1994
39
Spectral analysis of the electroencephalographic response to motion sickness. (8424736)
1993
40
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. (1546939)
1992
41
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. (1599177)
1992
42
Motion sickness and perception: a reappraisal of the sensory conflict approach. (1486361)
1992
43
Role of histamine in motion sickness in Suncus murinus. (1741719)
1991
44
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
45
Effects of ginger on motion sickness susceptibility and gastric function. (2062873)
1991
46
Habituation of motion sickness in the cat. (2012566)
1991
47
Hormonal changes after parabolic flight: implications on the development of motion sickness. (2241748)
1990
48
Comparison of various motion stimuli on motion sickness and acquisition of adaptation in Suncus Murinus. (2303099)
1990
49
Space motion sickness. (2197405)
1990
50
The vestibulo-ocular reflex and its possible roles in space motion sickness. (3675486)
1987

Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Compounds for genes affiliated with Motion Sickness

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Compounds related to Motion Sickness according to GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1repinotan43 2810.6HTR1A, HTR3A
2tandospirone43 2810.6HTR1A, HTR3A
31-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide439.6HTR3A, HTR1A
4zacopride43 2810.5HTR1A, HTR3A
5abecarnil439.5HTR3A, HTR1A
6alpha-methylserotonin439.5HTR3A, HTR1A
7phenylbiguanide439.5HTR1A, HTR3A
8(tfmpp)439.5HTR3A, HTR1A
9pizotifen28 4310.5HTR1A, HTR3A
10way 100635439.5HTR1A, HTR3A
11amperozide439.5HTR3A, HTR1A
121-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane439.5HTR1A, HTR3A
13gr 127935439.5HTR3A, HTR1A
14spiroxatrine43 2810.5ADRA2A, HTR1A
15quipazine43 2810.5HTR1A, HTR3A
16piribedil28 4310.5HTR1A, ADRA2A
178-hydroxy-2-(di-n-propylamino)tetralin439.5HTR3A, HTR1A
18cyanopindolol43 2810.5HTR3A, HTR1A
19mesulergine28 4310.5HTR1A, HTR3A
20m-chlorophenylpiperazine439.5HTR3A, HTR1A
21oxymetazoline43 28 1211.5ADRA2A, HTR1A
22tropisetron28 4310.5HTR1A, HTR3A
232-methyl-5-ht43 2810.5HTR3A, HTR1A
24mcpp439.4HTR1A, HTR3A
25ru 2496928 4310.4HTR1A, HTR3A
265-carboxamidotryptamine439.4HTR1A, HTR3A
27ipsapirone43 2810.4HTR1A, HTR3A
28pindolol43 28 1211.4HTR3A, HTR1A
29terguride43 2810.3ADRA2A, HTR1A
30zotepine43 2810.3HTR1A, HTR3A
31buspirone43 28 1211.3HTR3A, HTR1A
32trazodone43 28 1211.3ADRA2A, HTR1A
33ritanserin43 2810.2HTR1A, HTR3A
34bacteriorhodopsin439.2AQP1, HTR3A
35spiperone43 2810.1HTR3A, HTR1A
36metergoline43 2810.1HTR3A, HTR1A
37dihydroergotamine43 28 1211.1HTR3A, HTR1A, ADRA2A
38nefazodone43 49 1211.1HTR3A, HTR1A, ADRA2A
39mianserin43 28 1211.1ADRA2A, HTR3A, HTR1A
40ergotamine28 43 1211.1HTR1A, HTR3A, ADRA2A
41aripiprazole28 43 49 24 1213.1ADRA2A, HTR3A, HTR1A
42ziprasidone28 49 43 1212.1HTR1A, ADRA2A, HTR3A
43yohimbine43 2 28 1212.1ADRA2A, HTR3A, HTR1A
44amitriptyline43 28 49 1212.1ADRA2A, HTR1A, HTR3A
45quetiapine43 49 28 24 1213.1HTR3A, ADRA2A, HTR1A
46chlorpromazine28 43 49 1212.1HTR1A, ADRA2A, HTR3A
47risperidone43 49 28 59 24 1214.1HTR3A, ADRA2A, HTR1A
48olanzapine43 49 28 24 1213.1ADRA2A, HTR1A, HTR3A
49clozapine43 28 49 1212.1HTR3A, ADRA2A, HTR1A
50methiothepin43 289.8HTR3A, HTR1A

GO Terms for genes affiliated with Motion Sickness

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Cellular components related to Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.1AQP1, ADRA2A
2plasma membraneGO:00058868.1HTR1A, HTR3A, ADRA2A, AQP1
3integral component of plasma membraneGO:00058878.0HTR1A, HTR3A, ADRA2A, AQP1

Biological processes related to Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00072109.1HTR1A, HTR3A

Molecular functions related to Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00049939.1HTR1A, HTR3A

Products for genes affiliated with Motion Sickness

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Sources for Motion Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet