MCID: MTN003
MIFTS: 57

Motion Sickness malady

Summaries for Motion Sickness

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards: Motion Sickness, also known as travel sickness, unspecified, is related to space motion sickness and migraine. An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and Regulation of Water Balance by Renal Aquaporins. The drugs diphenhydramine hydrochloride and chlorcyclizine and the compounds repinotan and 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:63 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:46 158280

Aliases & Classifications for Motion Sickness

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

motion sickness 8 10 33 60
travel sickness, unspecified 8
motion sickness nos 8
travel sickness 8


External Ids:

Disease Ontology8 DOID:2951
ICD9CM27 994.6
OMIM46 158280
NCIt39 C34824
MeSH34 D009041
ICD1025 T75.3

Related Diseases for Motion Sickness

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17GeneCards, 18GeneDecks
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Diseases related to Motion Sickness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1space motion sickness31.5MMP11
2migraine30.9HTR1A, HTR3A, FOS, TAC1, TACR1
3neuronitis10.4
4yaws10.2
5seasonal affective disorder10.1
6vestibular neuronitis10.1
7vestibular nystagmus10.1
8hyperglycemia10.1
9dyspepsia10.0HTR3A
10anxiety disorder10.0HTR3A
11meningitis10.0AVP
12ischemia10.0HTR1A
13prion disease10.0AVP
14chronic fatigue syndrome10.0HTR1A
15anorexia nervosa10.0HTR3A, HTR1A
16premature ejaculation10.0HTR1A
17obesity10.0ADRA2A, HTR1A
18social phobia10.0HTR3A, HTR1A
19irritable bowel syndrome10.0TAC1, HTR3A
20constipation10.0HTR3A, TAC1
21nephrogenic diabetes insipidus10.0AVP, AQP1
22amnestic disorder10.0HTR1A, HTR3A
23panic disorder10.0HTR1A, HTR3A
24hypertension10.0AVP, TAC1
25colon adenocarcinoma10.0FOS
26neuroleptic malignant syndrome10.0HTR1A
27generalized anxiety disorder10.0HTR1A, HTR3A
28gilles de la tourette syndrome10.0HTR1A, ADRA2A
29serotonin syndrome10.0TAC1, HTR3A, HTR1A
30sudden infant death syndrome10.0HTR1A, HTR3A, TAC1
31bipolar disorder10.0HTR1A, HTR3A, TACR1
32cystitis10.0TACR1, TAC1
33fibromyalgia10.0TACR1, TAC1, HTR3A
34pancreatitis10.0TACR1, TAC1
35mood disorder10.0ADRA2A, TACR1, HTR3A, HTR1A
36colorectal cancer10.0MMP11, FOS, SAT1
37alzheimer's disease10.0AQP1, TACR1, HTR1A
38leukemia10.0SAT1, HTR3A, FOS
39parkinson's disease10.0TAC1, FOS, HTR1A
40adenocarcinoma10.0TAC1, TACR1, MMP11, ADRA2A, AQP1
41arthritis10.0FOS, TAC1, TACR1
42lung cancer10.0SAT1, HTR1A, FOS, MMP11
43colon cancer10.0SAT1, HTR3A, FOS, TAC1
44cholera10.0HTR1A, HTR3A, FOS, TAC1, ADRA2A
45glioblastoma multiforme10.0AQP1, TACR1, TAC1, FOS
46pain agnosia10.0HTR1A, HTR3A, FOS, TAC1, TACR1
47astrocytoma10.0AQP1, TACR1, TAC1, FOS
48schizophrenia10.0HTR1A, HTR3A, FOS, TAC1, TACR1, ADRA2A
49rheumatoid arthritis10.0FOS, TAC1, TACR1, MMP11
50malignant glioma10.0HTR1A, HTR3A, FOS, TAC1, TACR1, MMP11

Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Clinical Features for Motion Sickness

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Sources:
46OMIM
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Clinical features from OMIM:

158280

Drugs & Therapeutics for Motion Sickness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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32MalaCards
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MalaCards organs/tissues related to Motion Sickness:

32
Eye, Brain, Testes, Heart, Skin, Cerebellum, Amygdala, Hypothalamus

Animal Models for Motion Sickness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Motion Sickness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8TAC1, TACR1, MMP11, PTPRM, ADRA2A, AQP1
2MP:00053767.0SAT1, HTR1A, HTR3A, FOS, TACR1, AVP
3MP:00053866.6AQP1, HTR1A, HTR3A, FOS, PHLPP1, TAC1

Publications for Motion Sickness

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Sources:
50PubMed
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Articles related to Motion Sickness:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Neuronal mechanisms and the treatment of motion sickness. (23615033)
2013
2
Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sickness. (23712685)
2013
3
Processing of vestibular inputs by the medullary lateral tegmental field of conscious cats: implications for generation of motion sickness. (23274644)
2013
4
Space motion sickness and motion sickness: symptoms and etiology. (23855067)
2013
5
Pre-bout standing body sway differs between adult boxers who do and do not report post-bout motion sickness. (23056250)
2012
6
Ocular vestibular evoked myogenic potentials and motion sickness susceptibility. (22272511)
2012
7
Acute hyperglycemia is related to gastrointestinal symptoms in motion sickness: an experimental study. (21907224)
2012
8
Cognitive cues and visually induced motion sickness. (22606863)
2012
9
Effect of respiratory modulation on relationship between heart rate variability and motion sickness. (22254707)
2011
10
Eradication of Helicobacter pylori infection aids with the outcome of motion sickness adaptation. (20699613)
2011
11
Migraine and motion sickness independently contribute to visual discomfort. (19500116)
2010
12
Motion sickness in pilot trainees: management to keep them flying. (19817241)
2009
13
Visually induced motion sickness with radial displays: effects of gaze angle and fixation. (17679562)
2007
14
Motion sickness provoked by torso rotation. (17484352)
2007
15
EEG effects of motion sickness induced in a dynamic virtual reality environment. (18002844)
2007
16
Feeling queasy. EMS providers should be aware that many patients can experience motion sickness while riding in the ambulance. (17642334)
2007
17
Motion sickness during fore-and-aft oscillation: effect of the visual scene. (17183919)
2006
18
Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. (16369474)
2006
19
Effect of sporting activity practice on susceptibility to motion sickness. (16564424)
2006
20
Sex differences in tolerance to visually-induced motion sickness. (16018346)
2005
21
Effect of a novel motion desensitization training regime and controlled breathing on habituation to motion sickness. (16350630)
2005
22
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. (15828634)
2005
23
Motion sickness induced by optokinetic drums. (14960055)
2004
24
Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. (12650654)
2003
25
Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. (12576305)
2003
26
The critical role of velocity storage in production of motion sickness. (14662476)
2003
27
A new goldfish model to evaluate pharmacokinetic and pharmacodynamic effects of drugs used for motion sickness in different gravity loads. (11669128)
2001
28
Cabin location and the likelihood of motion sickness in cruise ship passengers. (11179940)
2000
29
Gender differences in motion sickness history and susceptibility to optokinetic rotation-induced motion sickness. (10608604)
1999
30
Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea. (10490040)
1999
31
Motion sickness in public road transport: the relative importance of motion, vision and individual differences. (10629944)
1999
32
Effects of gender of subjects and experimenter on susceptibility to motion sickness. (10519473)
1999
33
Visual-vestibular habituation and balance training for motion sickness. (10498971)
1999
34
Keeping motion sickness at bay. (9708043)
1998
35
Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. (10052582)
1998
36
Roll motion stimuli: sensory conflict, perceptual weighting and motion sickness. (10052579)
1998
37
Motion sickness and development of synergy within the spatial orientation system. A hypothetical unifying concept. (10052577)
1998
38
The significance of motion sickness in the vestibular system. (9178223)
1997
39
Comparison of the effects of a selective muscarinic receptor antagonist and hyoscine (scopolamine) on motion sickness, skin conductance and heart rate. (9205824)
1997
40
Unusual vestibular and visual input in human dynamic balance as a motion sickness susceptibility test. (9215463)
1997
41
Prophylactic effect of serotonin uptake inhibitors against motion sickness in Suncus murinus. (8864690)
1996
42
Motion sickness incidence during a round-the-world yacht race. (7487823)
1995
43
Phenytoin for motion sickness: clinical evaluation. (8052077)
1994
44
Separation of affective disorder into seasonal and nonseasonal types using motion sickness susceptibility as a marker. (8369644)
1993
45
Altered sensorimotor control of the body as an etiological factor in space motion sickness. (1930058)
1991
46
Hormonal changes after parabolic flight: implications on the development of motion sickness. (2241748)
1990
47
The susceptibility of rhesus monkeys to motion sickness. (2241745)
1990
48
The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate. (2683568)
1989
49
Clinical characterization and etiology of space motion sickness. (3499891)
1987
50
Variations in gravitoinertial force level affect the gain of the vestibulo-ocular reflex: implications for the etiology of space motion sickness. (6971638)
1981

Genetic Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Motion Sickness

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1repinotan44 2811.3HTR1A, HTR3A
21-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide4410.3HTR3A, HTR1A
3tandospirone44 2811.3HTR1A, HTR3A
4phenylbiguanide4410.3HTR1A, HTR3A
5alpha-methylserotonin4410.3HTR3A, HTR1A
6zacopride44 2811.3HTR3A, HTR1A
7abecarnil4410.2HTR3A, HTR1A
8pizotifen44 2811.2HTR1A, HTR3A
9way 1006354410.2HTR1A, HTR3A
10(tfmpp)4410.2HTR1A, HTR3A
11dihydroergotamine28 44 1112.2ADRA2A, HTR3A, HTR1A
12amperozide4410.1HTR1A, HTR3A
13nefazodone44 49 1112.1HTR3A, ADRA2A, HTR1A
14mianserin28 44 1112.1ADRA2A, HTR3A, HTR1A
15ergotamine28 44 1112.1HTR1A, ADRA2A, HTR3A
16aripiprazole28 49 44 11 2414.1ADRA2A, HTR3A, HTR1A
17ziprasidone49 28 44 1113.1HTR3A, HTR1A, ADRA2A
18amitriptyline44 49 28 1113.0ADRA2A, HTR1A, HTR3A
19quetiapine44 49 28 11 2414.0HTR3A, ADRA2A, HTR1A
20yohimbine44 28 2 1112.9HTR1A, HTR3A, ADRA2A, TAS2R38
21quinuclidine449.8TACR1, HTR3A
22apomorphine44 28 1111.8ADRA2A, FOS, HTR1A
232-methyl-5-ht44 2810.8HTR1A, TACR1, HTR3A
24risperidone28 44 49 59 11 2414.7HTR3A, ADRA2A, HTR1A
25clomipramine44 49 1111.7HTR1A, TACR1, HTR3A
26paroxetine44 49 28 1112.7HTR1A, TACR1, HTR3A
27ly30387044 2810.7TACR1, TAC1
28rp6758044 2810.7TAC1, TACR1
29gr 71251449.7TAC1, TACR1
30cp 96345449.6TAC1, TACR1
31olanzapine49 44 28 11 2413.6HTR3A, HTR1A, FOS, ADRA2A
32chlorpromazine44 28 49 1112.6ADRA2A, HTR1A, HTR3A
33ezlopitant44 2810.6TACR1, TAC1
34palonosetron44 1110.5TACR1, TAC1, HTR3A
35aprepitant44 28 1111.5TACR1, TAC1, HTR3A
36physalaemin44 2810.5TACR1, TAC1
37scopolamine44 28 11 2412.4HTR1A, TACR1, TAC1
38gr 82334449.4TAC1, TACR1
39osanetant28 4410.4TACR1, TAC1
40ondansetron44 49 11 2412.3TACR1, HTR3A, TAC1, HTR1A
41fluoxetine49 44 28 1112.2HTR1A, TAC1, TACR1, HTR3A
425-hydroxytryptamine449.2TACR1, HTR1A, HTR3A, TAC1
43clozapine44 28 49 1112.0HTR1A, HTR3A, ADRA2A, TACR1, FOS
44citalopram49 44 11 2412.0HTR1A, HTR3A, TACR1
45chloride448.8TACR1, TAC1, AQP1, AVP
46norepinephrine44 11 2410.8TAC1, TACR1, AVP, ADRA2A, HTR1A, HTR3A
47haloperidol44 28 2 49 1112.7FOS, TACR1, TAC1, HTR3A, HTR1A
48dopamine44 28 11 2411.5TAC1, HTR3A, HTR1A, FOS, ADRA2A, TACR1
49adenylate448.5HTR1A, HTR3A, FOS, TACR1, ADRA2A, TAC1
50dexamethasone44 49 28 1111.4TACR1, AQP1, FOS, HTR3A, AVP, TAC1

GO Terms for genes affiliated with Motion Sickness

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16Gene Ontology
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Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.0AQP1, ADRA2A, PTPRM, TACR1, RNF43, HTR3A

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.3AQP1, AVP
2serotonin receptor signaling pathwayGO:00721010.2HTR3A, HTR1A
3vasoconstrictionGO:04231010.1HTR1A, AVP
4inseminationGO:00732010.0TAC1, SEMG1
5positive regulation of vasodilationGO:0459099.9ADRA2A, PTPRM
6acute inflammatory responseGO:0025269.9ADRA2A, TACR1
7detection of abiotic stimulusGO:0095829.7TAC1, TACR1
8positive regulation of vasoconstrictionGO:0459079.7AVP, TACR1
9positive regulation of synaptic transmission, cholinergicGO:0322249.6TACR1, TAC1
10positive regulation of lymphocyte proliferationGO:0506719.6TAC1, TACR1
11positive regulation of action potentialGO:0457609.6TACR1, TAC1
12tachykinin receptor signaling pathwayGO:0072179.6TACR1, TAC1
13positive regulation of synaptic transmission, GABAergicGO:0322309.6TAC1, TACR1
14positive regulation of renal sodium excretionGO:0358159.5TACR1, TAC1
15response to nicotineGO:0350949.5TACR1, AVP
16positive regulation of epithelial cell migrationGO:0106349.5TAC1, TACR1
17associative learningGO:0083069.4TAC1, TACR1
18cellular response to hormone stimulusGO:0328709.4ADRA2A, FOS
19positive regulation of saliva secretionGO:0468789.4AQP1, TACR1, TAC1
20response to morphineGO:0432789.3TACR1, TAC1
21elevation of cytosolic calcium ion concentrationGO:0072049.3TAC1, TACR1, AVP

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.8AQP1, HTR1A, FOS, PHLPP1, RNF43, TAC1

Products for genes affiliated with Motion Sickness

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Sources for Motion Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet