MCID: MTN003
MIFTS: 54

Motion Sickness malady

Ear diseases category

Summaries for Motion Sickness

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Sources:
35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards: Motion Sickness, also known as travel sickness, unspecified, is related to migraine and space motion sickness. An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and SIDS Susceptibility Pathways. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide and repinotan have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:66 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:48 158280

Aliases & Classifications for Motion Sickness

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Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

motion sickness 9 11 35 63
travel sickness, unspecified 9
motion sickness nos 9
travel sickness 9


External Ids:

Disease Ontology9 DOID:2951
ICD9CM28 994.6
NCIt41 C34824
MeSH36 D009041
OMIM48 158280
ICD1026 T75.3

Related Diseases for Motion Sickness

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Symptoms for Motion Sickness

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Sources:
48OMIM
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Clinical features from OMIM:

158280

Drugs & Therapeutics for Motion Sickness

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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Sources:
34MalaCards
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MalaCards organs/tissues related to Motion Sickness:

34
Eye, Brain, Heart, Testes, Skin, Cerebellum, Amygdala, Hypothalamus

Animal Models for Motion Sickness or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Motion Sickness:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1HTR1A, HTR3A, ADRA2A, AQP1
2MP:00053858.0AQP1, MMP11, ADRA2A, HTR1A
3MP:00053867.8AQP1, ADRA2A, HTR3A, HTR1A
4MP:00053767.5HTR1A, HTR3A, ADRA2A, MMP11, AQP1

Publications for Motion Sickness

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Sources:
53PubMed
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Articles related to Motion Sickness:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Retraction note to: Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (23645569)
2013
2
Motion sickness in rally car co-drivers. (23713212)
2013
3
Expression of calcitonin gene-related peptide in efferent vestibular system and vestibular nucleus in rats with motion sickness. (23056625)
2012
4
Pre-bout standing body sway differs between adult boxers who do and do not report post-bout motion sickness. (23056250)
2012
5
Postural activity and motion sickness during video game play in children and adults. (22210118)
2012
6
Migraine and motion sickness: what is the link? (20416353)
2010
7
Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation. (19863229)
2009
8
Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate. (17903249)
2007
9
Evaluation of adaptation to visually induced motion sickness by using physiological index associated with baroreflex function. (18001950)
2007
10
Motion sickness and migraine. (17445111)
2007
11
Rotation direction change hastens motion sickness onset in an optokinetic drum. (16676663)
2006
12
Space motion sickness: incidence, etiology, and countermeasures. (16935570)
2006
13
Sex differences in tolerance to visually-induced motion sickness. (16018346)
2005
14
Vertigo and motion sickness. Part I: vestibular anatomy and physiology. (16261758)
2005
15
Visual field effects on motion sickness in cars. (15460624)
2004
16
Vector analysis of electrogastrography during motion sickness. (12757161)
2003
17
Effect of breathing supplemental oxygen on motion sickness in healthy adults. (12744544)
2003
18
Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. (11972579)
2002
19
Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness. (11911986)
2002
20
The correlation between aerobic fitness and motion sickness susceptibility. (11908888)
2002
21
Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats. (11132721)
2000
22
Postural instability and motion sickness in a fixed-based flight simulator. (11132807)
2000
23
Motion sickness occurrence does not correlate with nystagmus characteristics. (10841988)
2000
24
A comparison of motion sickness remedies in severe sea conditions. (10921365)
2000
25
Gender differences in motion sickness history and susceptibility to optokinetic rotation-induced motion sickness. (10608604)
1999
26
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness. (10597557)
1999
27
Keeping motion sickness at bay. (9708043)
1998
28
Postural instability precedes motion sickness. (10052572)
1998
29
Motion sickness susceptibility correlates with otolith- and canal-ocular reflexes. (9694209)
1998
30
Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. (10052582)
1998
31
Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (9260009)
1997
32
Optokinetic rotation-induced taste aversions correlate with over-all symptoms of motion sickness in humans. (8774022)
1996
33
The incidence and effects of motion sickness among medical attendants during transport. (7782619)
1995
34
Space motion sickness. (7741942)
1995
35
Motion Sickness. (9815382)
1995
36
Effects of dimenhydrinate on gastric tachyarrhythmia and symptoms of vection-induced motion sickness. (8588792)
1995
37
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. (11537946)
1994
38
Spectral analysis of the electroencephalographic response to motion sickness. (8424736)
1993
39
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. (1546939)
1992
40
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. (1599177)
1992
41
Motion sickness and perception: a reappraisal of the sensory conflict approach. (1486361)
1992
42
Susceptibility of divers in open water to motion sickness. (1536062)
1992
43
Role of histamine in motion sickness in Suncus murinus. (1741719)
1991
44
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
45
Effects of ginger on motion sickness susceptibility and gastric function. (2062873)
1991
46
Habituation of motion sickness in the cat. (2012566)
1991
47
Hormonal changes after parabolic flight: implications on the development of motion sickness. (2241748)
1990
48
Comparison of various motion stimuli on motion sickness and acquisition of adaptation in Suncus Murinus. (2303099)
1990
49
Space motion sickness. (2197405)
1990
50
The vestibulo-ocular reflex and its possible roles in space motion sickness. (3675486)
1987

Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB
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Compounds for genes affiliated with Motion Sickness

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
11-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide469.6HTR3A, HTR1A
2repinotan46 3010.6HTR3A, HTR1A
3tandospirone46 3010.6HTR3A, HTR1A
4phenylbiguanide469.5HTR3A, HTR1A
5abecarnil469.5HTR3A, HTR1A
6alpha-methylserotonin469.5HTR3A, HTR1A
7zacopride46 3010.5HTR3A, HTR1A
8pizotifen30 4610.5HTR3A, HTR1A
9(tfmpp)469.5HTR3A, HTR1A
10way 100635469.5HTR3A, HTR1A
11spiroxatrine46 3010.5ADRA2A, HTR1A
12amperozide469.5HTR3A, HTR1A
131-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane469.5HTR3A, HTR1A
14quipazine46 3010.5HTR3A, HTR1A
15piribedil30 4610.5ADRA2A, HTR1A
16gr 127935469.5HTR3A, HTR1A
178-hydroxy-2-(di-n-propylamino)tetralin469.5HTR3A, HTR1A
18cyanopindolol46 3010.5HTR1A, HTR3A
19mesulergine30 4610.5HTR3A, HTR1A
20m-chlorophenylpiperazine469.5HTR3A, HTR1A
21oxymetazoline46 30 1211.5ADRA2A, HTR1A
22tropisetron30 4610.5HTR1A, HTR3A
23ru 2496930 4610.4HTR3A, HTR1A
242-methyl-5-ht46 3010.4HTR3A, HTR1A
25mcpp469.4HTR3A, HTR1A
26ipsapirone46 3010.4HTR3A, HTR1A
275-carboxamidotryptamine469.4HTR3A, HTR1A
28pindolol46 30 1211.4HTR1A, HTR3A
29terguride46 3010.3HTR1A, ADRA2A
30buspirone46 30 1211.3HTR3A, HTR1A
31trazodone46 30 1211.3ADRA2A, HTR1A
32zotepine46 3010.3HTR3A, HTR1A
33ritanserin46 3010.2HTR3A, HTR1A
34spiperone46 3010.1HTR3A, HTR1A
355-hydroxytryptophan469.1HTR1A, HTR3A
36dihydroergotamine46 30 1211.1HTR1A, HTR3A, ADRA2A
37nefazodone46 52 1211.1HTR1A, HTR3A, ADRA2A
38mianserin46 30 1211.1ADRA2A, HTR3A, HTR1A
39ergotamine30 46 1211.1HTR1A, HTR3A, ADRA2A
40aripiprazole30 46 52 25 1213.1ADRA2A, HTR3A, HTR1A
41ziprasidone30 52 46 1212.1HTR1A, HTR3A, ADRA2A
42yohimbine46 3 30 1212.1HTR1A, HTR3A, ADRA2A
43amitriptyline46 30 52 1212.1ADRA2A, HTR3A, HTR1A
44quetiapine46 52 30 25 1213.1HTR1A, HTR3A, ADRA2A
45chlorpromazine30 46 52 1212.1ADRA2A, HTR3A, HTR1A
46risperidone46 52 30 62 25 1214.1HTR1A, HTR3A, ADRA2A
47olanzapine46 52 30 25 1213.1ADRA2A, HTR3A, HTR1A
48clozapine46 30 52 1212.1ADRA2A, HTR3A, HTR1A
49bacteriorhodopsin469.0AQP1, HTR3A
50methiothepin46 3010.0HTR3A, HTR1A

GO Terms for genes affiliated with Motion Sickness

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Sources:
17Gene Ontology
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Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP1, ADRA2A
2plasma membraneGO:0058868.1HTR1A, HTR3A, ADRA2A, AQP1
3integral component of plasma membraneGO:0058878.0HTR1A, HTR3A, ADRA2A, AQP1

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.1HTR1A, HTR3A

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.1HTR1A, HTR3A

Products for genes affiliated with Motion Sickness

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  • Antibodies
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Sources for Motion Sickness

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet