MCID: MTN003
MIFTS: 55

Motion Sickness malady

Ear diseases category

Summaries for Motion Sickness

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MedlinePlus:33 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards based summary: Motion Sickness, also known as travel sickness, unspecified, is related to migraine and space motion sickness, and has symptoms including abnormality of the nervous system An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and SIDS Susceptibility Pathways. The drugs diphenhydramine hydrochloride and chlorcyclizine and the compounds 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide and tandospirone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:64 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:46 158280

Aliases & Classifications for Motion Sickness

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Motion Sickness, Aliases & Descriptions:

Name: Motion Sickness 9 11 33 61
Travel Sickness, Unspecified 9
 
Motion Sickness Nos 9
Travel Sickness 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


External Ids:

Disease Ontology9 DOID:2951
ICD9CM28 994.6
OMIM46 158280
MeSH34 D009041
NCIt39 C34824
ICD1026 T75.3

Related Diseases for Motion Sickness

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Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Symptoms for Motion Sickness

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Clinical features from OMIM:

158280

HPO human phenotypes related to Motion Sickness:

id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707

Drugs & Therapeutics for Motion Sickness

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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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MalaCards organs/tissues related to Motion Sickness:

32
Eye, Brain, Heart, Testes, Skin, Cerebellum, Hypothalamus, Amygdala

Animal Models for Motion Sickness or affiliated genes

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MGI Mouse Phenotypes related to Motion Sickness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1HTR1A, HTR3A, ADRA2A, AQP1
2MP:00053858.0AQP1, MMP11, ADRA2A, HTR1A
3MP:00053867.8AQP1, ADRA2A, HTR3A, HTR1A
4MP:00053767.5HTR1A, HTR3A, ADRA2A, MMP11, AQP1

Publications for Motion Sickness

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Articles related to Motion Sickness:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Integration of vestibular and gastrointestinal inputs by cerebellar fastigial nucleus neurons: multisensory influences on motion sickness. (24677139)
2014
2
Motion sickness prevalence in school children. (24893949)
2014
3
Brainstem processing of vestibular sensory exafference: implications for motion sickness etiology. (24838552)
2014
4
The comparison of sensitivity of motion sickness between retinal degeneration fast mice and normal mice. (24553916)
2014
5
Retraction note to: Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (23645569)
2013
6
EEG-based learning system for online motion sickness level estimation in a dynamic vehicle environment. (24808604)
2013
7
Motion sickness in rally car co-drivers. (23713212)
2013
8
Expression of calcitonin gene-related peptide in efferent vestibular system and vestibular nucleus in rats with motion sickness. (23056625)
2012
9
Pre-bout standing body sway differs between adult boxers who do and do not report post-bout motion sickness. (23056250)
2012
10
Migraine and motion sickness: what is the link? (20416353)
2010
11
Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation. (19863229)
2009
12
Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate. (17903249)
2007
13
Evaluation of adaptation to visually induced motion sickness by using physiological index associated with baroreflex function. (18001950)
2007
14
Motion sickness and migraine. (17445111)
2007
15
Rotation direction change hastens motion sickness onset in an optokinetic drum. (16676663)
2006
16
Space motion sickness: incidence, etiology, and countermeasures. (16935570)
2006
17
Sex differences in tolerance to visually-induced motion sickness. (16018346)
2005
18
Vertigo and motion sickness. Part I: vestibular anatomy and physiology. (16261758)
2005
19
Visual field effects on motion sickness in cars. (15460624)
2004
20
Vector analysis of electrogastrography during motion sickness. (12757161)
2003
21
Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. (11972579)
2002
22
Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness. (11911986)
2002
23
Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats. (11132721)
2000
24
Postural instability and motion sickness in a fixed-based flight simulator. (11132807)
2000
25
Motion sickness occurrence does not correlate with nystagmus characteristics. (10841988)
2000
26
A comparison of motion sickness remedies in severe sea conditions. (10921365)
2000
27
Gender differences in motion sickness history and susceptibility to optokinetic rotation-induced motion sickness. (10608604)
1999
28
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness. (10597557)
1999
29
Keeping motion sickness at bay. (9708043)
1998
30
Postural instability precedes motion sickness. (10052572)
1998
31
Motion sickness susceptibility correlates with otolith- and canal-ocular reflexes. (9694209)
1998
32
Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. (10052582)
1998
33
Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (9260009)
1997
34
Optokinetic rotation-induced taste aversions correlate with over-all symptoms of motion sickness in humans. (8774022)
1996
35
The incidence and effects of motion sickness among medical attendants during transport. (7782619)
1995
36
Space motion sickness. (7741942)
1995
37
Motion Sickness. (9815382)
1995
38
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. (11537946)
1994
39
Spectral analysis of the electroencephalographic response to motion sickness. (8424736)
1993
40
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. (1546939)
1992
41
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. (1599177)
1992
42
Motion sickness and perception: a reappraisal of the sensory conflict approach. (1486361)
1992
43
Role of histamine in motion sickness in Suncus murinus. (1741719)
1991
44
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
45
Effects of ginger on motion sickness susceptibility and gastric function. (2062873)
1991
46
Habituation of motion sickness in the cat. (2012566)
1991
47
Hormonal changes after parabolic flight: implications on the development of motion sickness. (2241748)
1990
48
Comparison of various motion stimuli on motion sickness and acquisition of adaptation in Suncus Murinus. (2303099)
1990
49
Space motion sickness. (2197405)
1990
50
The vestibulo-ocular reflex and its possible roles in space motion sickness. (3675486)
1987

Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Compounds for genes affiliated with Motion Sickness

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Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
11-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide449.6HTR1A, HTR3A
2tandospirone44 2910.6HTR1A, HTR3A
3repinotan44 2910.6HTR1A, HTR3A
4abecarnil449.5HTR3A, HTR1A
5zacopride44 2910.5HTR3A, HTR1A
6alpha-methylserotonin449.5HTR3A, HTR1A
7phenylbiguanide449.5HTR3A, HTR1A
8pizotifen29 4410.5HTR1A, HTR3A
9way 100635449.5HTR1A, HTR3A
10(tfmpp)449.5HTR3A, HTR1A
11amperozide449.5HTR3A, HTR1A
12piribedil29 4410.5HTR1A, ADRA2A
131-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane449.5HTR3A, HTR1A
14quipazine44 2910.5HTR3A, HTR1A
15spiroxatrine44 2910.5ADRA2A, HTR1A
168-hydroxy-2-(di-n-propylamino)tetralin449.5HTR1A, HTR3A
17gr 127935449.5HTR1A, HTR3A
18cyanopindolol44 2910.5HTR3A, HTR1A
19m-chlorophenylpiperazine449.5HTR1A, HTR3A
20mesulergine29 4410.5HTR3A, HTR1A
21oxymetazoline44 29 1211.5ADRA2A, HTR1A
22tropisetron29 4410.5HTR3A, HTR1A
23ru 2496929 4410.5HTR3A, HTR1A
242-methyl-5-ht44 2910.4HTR3A, HTR1A
25mcpp449.4HTR1A, HTR3A
265-carboxamidotryptamine449.4HTR3A, HTR1A
27ipsapirone44 2910.4HTR3A, HTR1A
28pindolol44 29 1211.4HTR1A, HTR3A
29terguride44 2910.3ADRA2A, HTR1A
30bacteriorhodopsin449.3HTR3A, AQP1
31zotepine44 2910.3HTR1A, HTR3A
32trazodone44 29 1211.3HTR1A, ADRA2A
33buspirone44 29 1211.3HTR1A, HTR3A
34ritanserin44 2910.2HTR1A, HTR3A
355-hydroxytryptophan449.1HTR3A, HTR1A
36dihydroergotamine44 29 1211.1HTR1A, HTR3A, ADRA2A
37nefazodone44 50 1211.1HTR1A, ADRA2A, HTR3A
38mianserin44 29 1211.1HTR1A, ADRA2A, HTR3A
39ergotamine29 44 1211.1ADRA2A, HTR1A, HTR3A
40aripiprazole29 44 50 25 1213.1ADRA2A, HTR3A, HTR1A
41ziprasidone29 50 44 1212.1ADRA2A, HTR3A, HTR1A
42yohimbine44 3 29 1212.1HTR1A, ADRA2A, HTR3A
43amitriptyline44 29 50 1212.1HTR1A, ADRA2A, HTR3A
44quetiapine44 50 29 25 1213.1HTR1A, HTR3A, ADRA2A
45chlorpromazine29 44 50 1212.1HTR1A, HTR3A, ADRA2A
46risperidone44 50 29 60 25 1214.1HTR1A, HTR3A, ADRA2A
47olanzapine44 50 29 25 1213.1ADRA2A, HTR1A, HTR3A
48clozapine44 29 50 1212.1HTR1A, HTR3A, ADRA2A
49spiperone44 2910.0HTR3A, HTR1A
50methiothepin44 299.8HTR1A, HTR3A

GO Terms for genes affiliated with Motion Sickness

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Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP1, ADRA2A
2plasma membraneGO:0058868.1HTR1A, HTR3A, ADRA2A, AQP1
3integral component of plasma membraneGO:0058878.0HTR1A, HTR3A, ADRA2A, AQP1

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.1HTR1A, HTR3A

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.1HTR1A, HTR3A

Products for genes affiliated with Motion Sickness

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Sources for Motion Sickness

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet