MCID: MTN003
MIFTS: 54

Motion Sickness malady

Ear diseases category
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Summaries for Motion Sickness

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards: Motion Sickness, also known as travel sickness, unspecified, is related to migraine and space motion sickness. An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and SIDS Susceptibility Pathways. The drugs diphenhydramine hydrochloride and diphenhydramine and the compounds 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide and repinotan have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:65 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:47 158280

Aliases & Classifications for Motion Sickness

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 47OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

motion sickness 8 10 34 62
travel sickness, unspecified 8
motion sickness nos 8
travel sickness 8


External Ids:

Disease Ontology8 DOID:2951
ICD9CM27 994.6
NCIt40 C34824
MeSH35 D009041
OMIM47 158280
ICD1025 T75.3

Related Diseases for Motion Sickness

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Symptoms for Motion Sickness

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Sources:
47OMIM
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Clinical features from OMIM:

158280

Drugs & Therapeutics for Motion Sickness

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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Sources:
33MalaCards
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MalaCards organs/tissues related to Motion Sickness:

33
Eye, Brain, Heart, Testes, Skin, Cerebellum, Amygdala, Hypothalamus

Animal Models for Motion Sickness or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Motion Sickness:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1HTR1A, HTR3A, ADRA2A, AQP1
2MP:00053858.0AQP1, MMP11, ADRA2A, HTR1A
3MP:00053867.8AQP1, ADRA2A, HTR3A, HTR1A
4MP:00053767.5HTR1A, HTR3A, ADRA2A, MMP11, AQP1

Publications for Motion Sickness

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Sources:
52PubMed
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Articles related to Motion Sickness:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Retraction note to: Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (23645569)
2013
2
Motion sickness in rally car co-drivers. (23713212)
2013
3
Expression of calcitonin gene-related peptide in efferent vestibular system and vestibular nucleus in rats with motion sickness. (23056625)
2012
4
Pre-bout standing body sway differs between adult boxers who do and do not report post-bout motion sickness. (23056250)
2012
5
Postural activity and motion sickness during video game play in children and adults. (22210118)
2012
6
Migraine and motion sickness: what is the link? (20416353)
2010
7
Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensation. (19863229)
2009
8
Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate. (17903249)
2007
9
Evaluation of adaptation to visually induced motion sickness by using physiological index associated with baroreflex function. (18001950)
2007
10
Motion sickness and migraine. (17445111)
2007
11
Rotation direction change hastens motion sickness onset in an optokinetic drum. (16676663)
2006
12
Space motion sickness: incidence, etiology, and countermeasures. (16935570)
2006
13
Sex differences in tolerance to visually-induced motion sickness. (16018346)
2005
14
Vertigo and motion sickness. Part I: vestibular anatomy and physiology. (16261758)
2005
15
Visual field effects on motion sickness in cars. (15460624)
2004
16
Vector analysis of electrogastrography during motion sickness. (12757161)
2003
17
Effect of breathing supplemental oxygen on motion sickness in healthy adults. (12744544)
2003
18
Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. (11972579)
2002
19
Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness. (11911986)
2002
20
The correlation between aerobic fitness and motion sickness susceptibility. (11908888)
2002
21
Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats. (11132721)
2000
22
Postural instability and motion sickness in a fixed-based flight simulator. (11132807)
2000
23
Motion sickness occurrence does not correlate with nystagmus characteristics. (10841988)
2000
24
A comparison of motion sickness remedies in severe sea conditions. (10921365)
2000
25
Gender differences in motion sickness history and susceptibility to optokinetic rotation-induced motion sickness. (10608604)
1999
26
Prevention of postoperative vomiting with granisetron in paediatric patients with and without a history of motion sickness. (10597557)
1999
27
Keeping motion sickness at bay. (9708043)
1998
28
Postural instability precedes motion sickness. (10052572)
1998
29
Motion sickness susceptibility correlates with otolith- and canal-ocular reflexes. (9694209)
1998
30
Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. (10052582)
1998
31
Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. (9260009)
1997
32
Optokinetic rotation-induced taste aversions correlate with over-all symptoms of motion sickness in humans. (8774022)
1996
33
The incidence and effects of motion sickness among medical attendants during transport. (7782619)
1995
34
Space motion sickness. (7741942)
1995
35
Motion Sickness. (9815382)
1995
36
Effects of dimenhydrinate on gastric tachyarrhythmia and symptoms of vection-induced motion sickness. (8588792)
1995
37
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. (11537946)
1994
38
Spectral analysis of the electroencephalographic response to motion sickness. (8424736)
1993
39
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. (1546939)
1992
40
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. (1599177)
1992
41
Motion sickness and perception: a reappraisal of the sensory conflict approach. (1486361)
1992
42
Susceptibility of divers in open water to motion sickness. (1536062)
1992
43
Role of histamine in motion sickness in Suncus murinus. (1741719)
1991
44
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
45
Effects of ginger on motion sickness susceptibility and gastric function. (2062873)
1991
46
Habituation of motion sickness in the cat. (2012566)
1991
47
Hormonal changes after parabolic flight: implications on the development of motion sickness. (2241748)
1990
48
Comparison of various motion stimuli on motion sickness and acquisition of adaptation in Suncus Murinus. (2303099)
1990
49
Space motion sickness. (2197405)
1990
50
The vestibulo-ocular reflex and its possible roles in space motion sickness. (3675486)
1987

Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB
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Compounds for genes affiliated with Motion Sickness

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
11-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide459.6HTR3A, HTR1A
2repinotan45 2910.6HTR3A, HTR1A
3tandospirone45 2910.6HTR3A, HTR1A
4phenylbiguanide459.5HTR3A, HTR1A
5abecarnil459.5HTR3A, HTR1A
6alpha-methylserotonin459.5HTR3A, HTR1A
7zacopride45 2910.5HTR3A, HTR1A
8pizotifen29 4510.5HTR3A, HTR1A
9(tfmpp)459.5HTR3A, HTR1A
10way 100635459.5HTR3A, HTR1A
11spiroxatrine45 2910.5ADRA2A, HTR1A
12amperozide459.5HTR3A, HTR1A
131-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane459.5HTR3A, HTR1A
14quipazine45 2910.5HTR3A, HTR1A
15piribedil29 4510.5ADRA2A, HTR1A
16gr 127935459.5HTR3A, HTR1A
178-hydroxy-2-(di-n-propylamino)tetralin459.5HTR3A, HTR1A
18cyanopindolol45 2910.5HTR1A, HTR3A
19mesulergine29 4510.5HTR3A, HTR1A
20m-chlorophenylpiperazine459.5HTR3A, HTR1A
21oxymetazoline45 29 1111.5ADRA2A, HTR1A
22tropisetron29 4510.5HTR1A, HTR3A
23ru 2496929 4510.4HTR3A, HTR1A
242-methyl-5-ht45 2910.4HTR3A, HTR1A
25mcpp459.4HTR3A, HTR1A
26ipsapirone45 2910.4HTR3A, HTR1A
275-carboxamidotryptamine459.4HTR3A, HTR1A
28pindolol45 29 1111.4HTR1A, HTR3A
29terguride45 2910.3HTR1A, ADRA2A
30buspirone45 29 1111.3HTR3A, HTR1A
31trazodone45 29 1111.3ADRA2A, HTR1A
32zotepine45 2910.3HTR3A, HTR1A
33ritanserin45 2910.2HTR3A, HTR1A
34spiperone45 2910.1HTR3A, HTR1A
355-hydroxytryptophan459.1HTR1A, HTR3A
36dihydroergotamine45 29 1111.1HTR1A, HTR3A, ADRA2A
37nefazodone45 51 1111.1HTR1A, HTR3A, ADRA2A
38mianserin45 29 1111.1ADRA2A, HTR3A, HTR1A
39ergotamine29 45 1111.1HTR1A, HTR3A, ADRA2A
40aripiprazole29 45 51 24 1113.1ADRA2A, HTR3A, HTR1A
41ziprasidone29 51 45 1112.1HTR1A, HTR3A, ADRA2A
42yohimbine45 3 29 1112.1HTR1A, HTR3A, ADRA2A
43amitriptyline45 29 51 1112.1ADRA2A, HTR3A, HTR1A
44quetiapine45 51 29 24 1113.1HTR1A, HTR3A, ADRA2A
45chlorpromazine29 45 51 1112.1ADRA2A, HTR3A, HTR1A
46risperidone45 51 29 61 24 1114.1HTR1A, HTR3A, ADRA2A
47olanzapine45 51 29 24 1113.1ADRA2A, HTR3A, HTR1A
48clozapine45 29 51 1112.1ADRA2A, HTR3A, HTR1A
49bacteriorhodopsin459.0AQP1, HTR3A
50methiothepin45 2910.0HTR3A, HTR1A

GO Terms for genes affiliated with Motion Sickness

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Sources:
16Gene Ontology
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Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP1, ADRA2A
2plasma membraneGO:0058868.1HTR1A, HTR3A, ADRA2A, AQP1
3integral component of plasma membraneGO:0058878.0HTR1A, HTR3A, ADRA2A, AQP1

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.1HTR1A, HTR3A

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.1HTR1A, HTR3A

Products for genes affiliated with Motion Sickness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Motion Sickness

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet