MCID: MTN003
MIFTS: 57

Motion Sickness malady

Summaries for Motion Sickness

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. motion sickness can start suddenly, with a queasy feeling and cold sweats. it can then lead to dizziness and nausea and vomiting. your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. when it gets signals that do not match, you can get motion sickness. for example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving. where you sit can make a difference. the front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. looking out into the distance - instead of trying to read or look at something in the vehicle - can also help. centers for disease control and prevention

MalaCards: Motion Sickness, also known as travel sickness, unspecified, is related to space motion sickness and migraine. An important gene associated with Motion Sickness is ADRA2A (adrenoceptor alpha 2A), and among its related pathways are Monoamine GPCRs and Regulation of Water Balance by Renal Aquaporins. The drugs diphenhydramine hydrochloride and chlorcyclizine and the compounds repinotan and 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:63 Motion sickness or kinetosis, also known as travel sickness, is a condition in which a disagreement... more...

Description from OMIM:46 158280

Aliases & Classifications for Motion Sickness

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

motion sickness 8 10 33 60
travel sickness, unspecified 8
motion sickness nos 8
travel sickness 8


External Ids:

Disease Ontology8 DOID:2951
ICD9CM27 994.6
OMIM46 158280
NCIt39 C34824
MeSH34 D009041
ICD1025 T75.3

Related Diseases for Motion Sickness

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Motion Sickness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1space motion sickness31.5MMP11
2migraine30.9HTR1A, HTR3A, FOS, TAC1, TACR1
3neuronitis10.4
4yaws10.2
5seasonal affective disorder10.1
6vestibular neuronitis10.1
7vestibular nystagmus10.1
8hyperglycemia10.1
9dyspepsia10.0HTR3A
10anxiety disorder10.0HTR3A
11meningitis10.0AVP
12ischemia10.0HTR1A
13prion disease10.0AVP
14chronic fatigue syndrome10.0HTR1A
15anorexia nervosa10.0HTR3A, HTR1A
16premature ejaculation10.0HTR1A
17obesity10.0ADRA2A, HTR1A
18social phobia10.0HTR3A, HTR1A
19irritable bowel syndrome10.0TAC1, HTR3A
20constipation10.0HTR3A, TAC1
21nephrogenic diabetes insipidus10.0AVP, AQP1
22amnestic disorder10.0HTR1A, HTR3A
23panic disorder10.0HTR1A, HTR3A
24hypertension10.0AVP, TAC1
25colon adenocarcinoma10.0FOS
26neuroleptic malignant syndrome10.0HTR1A
27generalized anxiety disorder10.0HTR1A, HTR3A
28gilles de la tourette syndrome10.0HTR1A, ADRA2A
29serotonin syndrome10.0TAC1, HTR3A, HTR1A
30sudden infant death syndrome10.0HTR1A, HTR3A, TAC1
31bipolar disorder10.0HTR1A, HTR3A, TACR1
32cystitis10.0TACR1, TAC1
33fibromyalgia10.0TACR1, TAC1, HTR3A
34pancreatitis10.0TACR1, TAC1
35mood disorder10.0ADRA2A, TACR1, HTR3A, HTR1A
36colorectal cancer10.0MMP11, FOS, SAT1
37alzheimer's disease10.0AQP1, TACR1, HTR1A
38leukemia10.0SAT1, HTR3A, FOS
39parkinson's disease10.0TAC1, FOS, HTR1A
40adenocarcinoma10.0TAC1, TACR1, MMP11, ADRA2A, AQP1
41arthritis10.0FOS, TAC1, TACR1
42lung cancer10.0SAT1, HTR1A, FOS, MMP11
43colon cancer10.0SAT1, HTR3A, FOS, TAC1
44cholera10.0HTR1A, HTR3A, FOS, TAC1, ADRA2A
45glioblastoma multiforme10.0AQP1, TACR1, TAC1, FOS
46pain agnosia10.0HTR1A, HTR3A, FOS, TAC1, TACR1
47astrocytoma10.0AQP1, TACR1, TAC1, FOS
48schizophrenia10.0HTR1A, HTR3A, FOS, TAC1, TACR1, ADRA2A
49rheumatoid arthritis10.0FOS, TAC1, TACR1, MMP11
50malignant glioma10.0HTR1A, HTR3A, FOS, TAC1, TACR1, MMP11

Graphical network of the top 20 diseases related to Motion Sickness:



Diseases related to motion sickness

Clinical Features for Motion Sickness

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Sources:
46OMIM
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Clinical features from OMIM:

158280

Drugs & Therapeutics for Motion Sickness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Motion Sickness

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Anatomical Context for Motion Sickness

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32MalaCards
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MalaCards organs/tissues related to Motion Sickness:

32
Eye, Brain, Heart, Testes, Skin, Cerebellum, Hypothalamus, Amygdala

Animal Models for Motion Sickness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Motion Sickness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8TAC1, TACR1, MMP11, PTPRM, ADRA2A, AQP1
2MP:00053767.0SAT1, HTR1A, HTR3A, FOS, TACR1, AVP
3MP:00053866.6AQP1, HTR1A, HTR3A, FOS, PHLPP1, TAC1

Publications for Motion Sickness

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50PubMed
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Articles related to Motion Sickness:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Reduction of motion sickness with an enhanced placebo instruction: an experimental study with healthy participants. (23697466)
2013
2
Verification of motion sickness index in mice. (22117804)
2011
3
The ups and downs of motion sickness. (21107067)
2010
4
Visual stress, its treatment with spectral filters, and its relationship to visually induced motion sickness. (19286164)
2010
5
Isolating the effects of vection and optokinetic nystagmus on optokinetic rotation-induced motion sickness. (20196298)
2009
6
Motion sickness with fully roll-compensated lateral oscillation: effect of oscillation frequency. (19198194)
2009
7
Motion sickness may be caused by a neurohumoral action of acetylcholine. (19497682)
2009
8
Demand characteristics in assessing motion sickness in a virtual environment: or does taking a motion sickness questionnaire make you sick? (17356210)
2007
9
Genetic influences on motion sickness susceptibility in adult women: a classical twin study. (17086768)
2006
10
Proposed mechanisms and treatment strategies for motion sickness disorder: a case series. (19674668)
2006
11
Stroboscopic vision as a treatment for motion sickness: strobe lighting vs. shutter glasses. (16422446)
2006
12
Gastric arrhythmia and nausea of motion sickness induced in healthy Japanese subjects viewing an optokinetic rotating drum. (17002813)
2006
13
Motion sickness susceptibility associated with visually induced postural instability and cardiac autonomic responses in healthy subjects. (15966698)
2005
14
Vasopressin: neurohumoral link between nausea and motion sickness. (16110700)
2005
15
Rotation direction change hastens motion sickness onset in an optokinetic drum. (16173677)
2005
16
Visual field effects on motion sickness in cars. (15460624)
2004
17
Patient Notes: motion sickness. (15510594)
2004
18
Eye movement, vection, and motion sickness with foveal and peripheral vision. (12793532)
2003
19
Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. (11972579)
2002
20
Squirrel monkeys and space motion sickness. (12047798)
2002
21
A randomised, placebo-controlled study comparing two formulations of dimenhydrinate with respect to efficacy in motion sickness and sedation. (12189776)
2002
22
Motion sickness occurrence does not correlate with nystagmus characteristics. (10841988)
2000
23
The effects of serotonin (5-HT3) receptor antagonists on gastric tachyarrhythmia and the symptoms of motion sickness. (11086664)
2000
24
Vestibular autonomic regulation (including motion sickness and the mechanism of vomiting). (10097881)
1999
25
Motion sickness amelioration induced by prism spectacles. (10052581)
1998
26
I heard that the adhesive patch you can wear to prevent motion sickness is available again. Why was it taken off the market? (9516375)
1998
27
Effect of hypoxia on motion sickness induced by optokinetic stimulation. (11541259)
1998
28
Human heart rate variability relation is unchanged during motion sickness. (9416595)
1998
29
Motion sickness: only one provocative conflict? (10052578)
1998
30
On the origin of interindividual susceptibility to motion sickness. (9105436)
1997
31
Antiemetic effects of granisetron on postoperative nausea and vomiting in patients with and without motion sickness. (8825534)
1996
32
The effect of autogenic training and biofeedback on motion sickness tolerance. (9025819)
1996
33
P6 acupressure reduces symptoms of vection-induced motion sickness. (7575310)
1995
34
Study on experimental motion sickness in children. (8073856)
1994
35
Treatment efficacy of intramuscular promethazine for space motion sickness. (8447805)
1993
36
Motion sickness induced by sinusoidal linear acceleration in rats. (8447222)
1993
37
Motion sickness and perception: a reappraisal of the sensory conflict approach. (1486361)
1992
38
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. (11537575)
1992
39
Role of histamine in motion sickness in Suncus murinus. (1741719)
1991
40
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
41
Sensory interaction and methods of non-medicinal prophylaxis of space motion sickness. (2047451)
1991
42
Orientation perception, motion sickness and vertigo: beyond the sensory conflict approach. (1773201)
1991
43
Otolith function in hypo- and hypergravity: relation to space motion sickness. (1927373)
1991
44
Motion sickness. Helping patients tolerate the ups and downs. (2020643)
1991
45
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. (2012564)
1991
46
Therapeutic effects of antimotion sickness medications on the secondary symptoms of motion sickness. (2178599)
1990
47
Motion sickness--vestibular habituation with the centrifuge. (2321107)
1990
48
Comparison of aerobic fitness and space motion sickness during the shuttle program. (3390102)
1988
49
Space motion sickness: etiological hypotheses and a proposal for diagnostic clinical examination. (3924014)
1985
50
Space motion sickness: phenomenology, countermeasures, and mechanisms. (6847567)
1983

Genetic Variations for Motion Sickness

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Expression for genes affiliated with Motion Sickness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Motion Sickness

Search GEO for disease gene expression data for Motion Sickness.

Pathways for genes affiliated with Motion Sickness

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Motion Sickness

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Motion Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1repinotan44 2811.3HTR1A, HTR3A
21-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide4410.3HTR3A, HTR1A
3tandospirone44 2811.3HTR1A, HTR3A
4phenylbiguanide4410.3HTR1A, HTR3A
5alpha-methylserotonin4410.3HTR3A, HTR1A
6zacopride44 2811.3HTR3A, HTR1A
7abecarnil4410.2HTR3A, HTR1A
8pizotifen44 2811.2HTR1A, HTR3A
9way 1006354410.2HTR1A, HTR3A
10(tfmpp)4410.2HTR1A, HTR3A
11dihydroergotamine28 44 1112.2ADRA2A, HTR3A, HTR1A
12amperozide4410.1HTR1A, HTR3A
13nefazodone44 49 1112.1HTR3A, ADRA2A, HTR1A
14mianserin28 44 1112.1ADRA2A, HTR3A, HTR1A
15ergotamine28 44 1112.1HTR1A, ADRA2A, HTR3A
16aripiprazole28 49 44 11 2414.1ADRA2A, HTR3A, HTR1A
17ziprasidone49 28 44 1113.1HTR3A, HTR1A, ADRA2A
18amitriptyline44 49 28 1113.0ADRA2A, HTR1A, HTR3A
19quetiapine44 49 28 11 2414.0HTR3A, ADRA2A, HTR1A
20yohimbine44 28 2 1112.9HTR1A, HTR3A, ADRA2A, TAS2R38
21quinuclidine449.8TACR1, HTR3A
22apomorphine44 28 1111.8ADRA2A, FOS, HTR1A
232-methyl-5-ht44 2810.8HTR1A, TACR1, HTR3A
24risperidone28 44 49 59 11 2414.7HTR3A, ADRA2A, HTR1A
25clomipramine44 49 1111.7HTR1A, TACR1, HTR3A
26paroxetine44 49 28 1112.7HTR1A, TACR1, HTR3A
27ly30387044 2810.7TACR1, TAC1
28rp6758044 2810.7TAC1, TACR1
29gr 71251449.7TAC1, TACR1
30cp 96345449.6TAC1, TACR1
31olanzapine49 44 28 11 2413.6HTR3A, HTR1A, FOS, ADRA2A
32chlorpromazine44 28 49 1112.6ADRA2A, HTR1A, HTR3A
33ezlopitant44 2810.6TACR1, TAC1
34palonosetron44 1110.5TACR1, TAC1, HTR3A
35aprepitant44 28 1111.5TACR1, TAC1, HTR3A
36physalaemin44 2810.5TACR1, TAC1
37scopolamine44 28 11 2412.4HTR1A, TACR1, TAC1
38gr 82334449.4TAC1, TACR1
39osanetant28 4410.4TACR1, TAC1
40ondansetron44 49 11 2412.3TACR1, HTR3A, TAC1, HTR1A
41fluoxetine49 44 28 1112.2HTR1A, TAC1, TACR1, HTR3A
425-hydroxytryptamine449.2TACR1, HTR1A, HTR3A, TAC1
43clozapine44 28 49 1112.0HTR1A, HTR3A, ADRA2A, TACR1, FOS
44citalopram49 44 11 2412.0HTR1A, HTR3A, TACR1
45chloride448.8TACR1, TAC1, AQP1, AVP
46norepinephrine44 11 2410.8TAC1, TACR1, AVP, ADRA2A, HTR1A, HTR3A
47haloperidol44 28 2 49 1112.7FOS, TACR1, TAC1, HTR3A, HTR1A
48dopamine44 28 11 2411.5TAC1, HTR3A, HTR1A, FOS, ADRA2A, TACR1
49adenylate448.5HTR1A, HTR3A, FOS, TACR1, ADRA2A, TAC1
50dexamethasone44 49 28 1111.4TACR1, AQP1, FOS, HTR3A, AVP, TAC1

GO Terms for genes affiliated with Motion Sickness

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16Gene Ontology
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Cellular components related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.0AQP1, ADRA2A, PTPRM, TACR1, RNF43, HTR3A

Biological processes related to Motion Sickness according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.3AQP1, AVP
2serotonin receptor signaling pathwayGO:00721010.2HTR3A, HTR1A
3vasoconstrictionGO:04231010.1HTR1A, AVP
4inseminationGO:00732010.0TAC1, SEMG1
5positive regulation of vasodilationGO:0459099.9ADRA2A, PTPRM
6acute inflammatory responseGO:0025269.9ADRA2A, TACR1
7detection of abiotic stimulusGO:0095829.7TAC1, TACR1
8positive regulation of vasoconstrictionGO:0459079.7AVP, TACR1
9positive regulation of synaptic transmission, cholinergicGO:0322249.6TACR1, TAC1
10positive regulation of lymphocyte proliferationGO:0506719.6TAC1, TACR1
11positive regulation of action potentialGO:0457609.6TACR1, TAC1
12tachykinin receptor signaling pathwayGO:0072179.6TACR1, TAC1
13positive regulation of synaptic transmission, GABAergicGO:0322309.6TAC1, TACR1
14positive regulation of renal sodium excretionGO:0358159.5TACR1, TAC1
15response to nicotineGO:0350949.5TACR1, AVP
16positive regulation of epithelial cell migrationGO:0106349.5TAC1, TACR1
17associative learningGO:0083069.4TAC1, TACR1
18cellular response to hormone stimulusGO:0328709.4ADRA2A, FOS
19positive regulation of saliva secretionGO:0468789.4AQP1, TACR1, TAC1
20response to morphineGO:0432789.3TACR1, TAC1
21elevation of cytosolic calcium ion concentrationGO:0072049.3TAC1, TACR1, AVP

Molecular functions related to Motion Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.8AQP1, HTR1A, FOS, PHLPP1, RNF43, TAC1

Products for genes affiliated with Motion Sickness

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Sources for Motion Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet