Motor Neuron Disease malady

NINDS: The motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy cells that control essential muscle activity such as speaking, walking, breathing, and swallowing.³¹

MalaCards: Motor Neuron Disease, also known as motor neuron diseases, is related to lower motor neuron disease and lateral sclerosis. An important gene associated with Motor Neuron Disease is SOD2 (superoxide dismutase 2, mitochondrial), and among its related pathways are Pathogenesis of ALS and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds levodopa and silver have been mentioned in the context of this disorder. Affiliated tissues include the motor neurones, brain and cortex, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Disease Ontology: A neurodegenerative disease that is located in the motor neurones.⁶

Wikipedia: The motor neuron diseases (MND) are a group of neurological disorders that selectively affect motor...⁴⁴ more...

Aliases & Descriptions:

motor neuron disease 6 8 32 43 motor neuron diseases 31

Diseases related to motor neuron disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 495)

id	Related Disease	Score	Top Affiliating Genes
1	lower motor neuron disease	35.3	BTD, SMN1, SMN2, SYP, SOD1
2	lateral sclerosis	35.3	ARHGEF2, MAPT, ALS2, SPAST, SNCA, SOD1
3	amyotrophic lateral sclerosis	35.0	VEGFA, DCTN1, NEFH
4	frontotemporal dementia	32.9	VCP, BDNF, INA, GRN, APOE, MAPT
5	spinal muscular atrophy	31.6	CNTF, NAIP, CHAT, SMN1, SMN2, HEXA
6	gangliosidosis	30.4	SMN1, HEXA, HEXB, GALC
7	hereditary spastic paraplegia	29.9	BSCL2, ATL1, SPAST, SPG20, SPG7, SLC1A2
8	spastic paraplegia	29.8	BSCL2, ATL1, ALS2, SPAST, SPG20, SPG7
9	paraplegia	29.8	BSCL2, ATL1, ALS2, SPAST, SPG20, SPG7
10	diabetic neuropathy	29.0	CNTF, INS, NGF, GDNF
11	pick's disease	28.9	BDNF, CHAT, UCHL1, GRN, APOE, MAPT
12	muscular atrophy	28.5	CNTF, BSCL2, NAIP, VAPB, CHAT, ATXN1
13	dementia	27.3	NAT2, VEGFA, VCP, BDNF, CHAT, UCHL1
14	spasticity	27.1	BTD, BSCL2, VEGFA, ATL1, ARHGEF2, INS
15	amyotrophic lateral sclerosis (als)	27.1	CNTF, SETX, VEGFA, RAB5A, GRIA2, IGF1
16	ataxia	25.6	BTD, SETX, UBC, ATXN1, ARHGEF2, AR
17	polyneuropathy	25.1	CNTF, VEGFA, LIF, INS, GSTM1, GSTT1
18	neuronitis	22.9	RET, CNTF, KIF3B, BTD, SETX, BSCL2
19	neuropathy	22.4	CNTF, BTD, SETX, BSCL2, NAIP, VEGFA
20	neurodegeneration	21.4	CNTF, BSCL2, NAIP, VEGFA, VCP, LIF
21	cerebritis	21.1	CNTF, BTD, VEGFA, LIF, LIFR, BDNF
22	spinal muscular atrophy 1	14.0	NAIP, SMN1, SMN2, RPS27A, SYP
23	spinal muscular atrophy type 2	14.0	NAIP, SMN1, SMN2
24	juvenile spinal muscular atrophy	14.0	NAIP, SMN1, SMN2
25	amyotrophic lateral sclerosis with frontotemporal dementia	14.0	GRN, RPS27A, TARDBP, SOD1
26	perry syndrome	14.0	GRN, TARDBP, DCTN1
27	spastic paralysis	14.0	ARHGEF2, ALS2, TARDBP
28	spinal cord disease	13.9	BTD, NAIP, SMN1, SMN2, GDNF
29	tay-sachs disease	13.9	SMN1, HEXA, HEXB
30	neuromuscular disease	13.9	NAIP, AR, SMN1, SMN2, DCTN1, GDNF
31	frontotemporal lobar degeneration with ubiquitin-positive inclusions	13.9	GRN, LOC643387, RPS27A, TARDBP, SQSTM1
32	motor neuronopathy	13.9	CNTF, AR, PLEKHG5, DCTN1
33	primary progressive aphasia	13.9	GRN, MAPT, TARDBP
34	tauopathy	13.9	INA, GRN, MAPT, SNCA, RPS27A
35	transient cerebral ischemia	13.8	MAPT, HSPA4, RPS27A, PVALB, SOD1, SOD2
36	corticobasal degeneration	13.8	MAPT, SNCA, RPS27A, TARDBP
37	myofibrillar myopathy	13.8	RPS27A, SQSTM1, SOD2
38	chorea	13.8	BDNF, RPS27A, TARDBP, SYP, GEMIN2
39	temporal lobe epilepsy	13.8	BDNF, CALB1, PVALB, SLC1A3, SLC1A2, GDNF
40	parkinson's disease	13.7	UCHL1, MAPT, SNCA
41	gaze palsy	13.7	MAPT, SNCA, TARDBP
42	niemann–pick disease	13.7	MAPT, MAG, SNCA, HEXA
43	neuronal intranuclear inclusion disease	13.7	ATXN1, MAPT, SNCA, RPS27A
44	alcohol abuse	13.6	GRIA2, CYP2E1, RPS27A, SOD1, SLC1A3
45	neuroaxonal dystrophy	13.6	SNCA, RPS27A, NGF
46	olivopontocerebellar atrophy	13.6	ATXN1, AR, PVALB
47	inclusion body myopathy	13.6	VCP, SNCA, RPS27A, NGF, TARDBP
48	movement disease	13.6	MAPT, CYP2D6, SNCA, RPS27A
49	proximal spinal muscular atrophy	13.6	NAIP, VAPB, APOE, SMN1, SMN2
50	semantic dementia	13.5	GRN, APOE, MAPT, RPS27A, TARDBP

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

Neuronal progenitors, PMIDs: 15118094, 16802299

MalaCards organs/tissues related to motor neuron disease:

²²

FMA organs/tissues related to motor neuron disease:

¹¹

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Spinal Cord -> Motor Neural Progenitor Domain -> Motor Neural Progenitor Cells	Potential therapeutic candidate
2	Spinal Cord -> Motor Neural Progenitor Domain -> Motor Neurons	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to motor neuron disease:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.2	GDNF, SOD2, SQSTM1, TIA1, HEXB, GRN
2	endocrine/exocrine gland phenotype	MP:0005379	9.6	HEXB, AMPH, RET
3	hearing/vestibular/ear phenotype	MP:0005377	9.1	SLC1A3, SOD2, SOD1, HEXB, HEXA, SMN1
4	immune system phenotype	MP:0005387	8.8	GFRA1, TIA1, PVR, SQSTM1, SOD2, GALC
5	liver/biliary system phenotype	MP:0005370	8.4	GALC, SOD1, SQSTM1, HEXB, HEXA, CYP2E1
6	no phenotypic analysis	MP:0003012	8.4	SNCA, SMN1, TARDBP, SYP, SLC1A3, MYH7
7	reproductive system phenotype	MP:0005389	7.9	SPAST, SNCA, SMN1, COL17A1, ELAVL4, SOD2
8	adipose tissue phenotype	MP:0005375	7.4	CTF1, NOS1, HEXB, TARDBP, SQSTM1, SOD2
9	skeleton phenotype	MP:0005390	7.2	SNCA, SMN1, NOS1, HEXA, HEXB, TIA1
10	normal phenotype	MP:0002873	6.9	PVALB, GFRA1, NOS1, SMN1, SPAST, IGF1
11	digestive/alimentary phenotype	MP:0005381	6.9	TNF, SNCA, SMN1, NOS1, GFRA1, GDNF
12	nervous system phenotype	MP:0003631	6.8	CNTF, SPAST, SPG20, SPG7, CTF1, SNCA
13	mortality/aging	MP:0010768	6.2	HEXA, NGF, COL17A1, NOS1, PNPLA6, SMN1
14	cardiovascular system phenotype	MP:0005385	5.4	SNCA, SMN1, PNPLA6, PLEKHG5, NOS1, SOD1
15	cellular phenotype	MP:0005384	4.4	PVALB, GFRA1, HEXB, ELAVL4, NOS1, PNPLA6
16	vision/eye phenotype	MP:0005391	INF	NGF, HEXA, HEXB, SOD1, SOD2, SLC1A3
17	muscle phenotype	MP:0005369	INF	ALS2, TNF, SMN1, NOS1, HEXB, GFRA1
18	renal/urinary system phenotype	MP:0005367	INF	SNCA, PLEKHG5, HEXA, HEXB, GFRA1, SOD2
19	homeostasis/metabolism phenotype	MP:0005376	INF	RET, CNTF, , BSCL2, NAIP, NAT1
20	growth/size phenotype	MP:0005378	INF	PNPLA6, SMN1, SNCA, CTF1, SPG7, GH1
21	behavior/neurological phenotype	MP:0005386	INF	PNPLA6, GALC, GDNF, SIGMAR1, NEFM, NEFH
22	integument phenotype	MP:0010771	INF	SMN1, PNPLA6, COL17A1, NGF, GFRA1, SQSTM1

Articles related to motor neuron disease:

(show top 50)    (show all 152)

id	Title	Authors	Year	Affiliating Genes
1	Sigma nonopioid intracellular receptor 1 mutations ca use frontotemporal lobar degeneration-motor neuron disease. (21031579)	Luty A.A.... Schofield P.R.	2010	SIGMAR1
2	Motor neuron disease due to neuropathy target esteras e mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis. (20603202)	Hein N.D.... Fink J.K.	2010	PNPLA6
3	TDP-43 proteinopathy and motor neuron disease in chro nic traumatic encephalopathy. (20720505)	McKee A.C.... Budson A.E.	2010	TARDBP
4	Increased neuronal Rab5 immunoreactive endosomes do n ot colocalize with TDP-43 in motor neuron disease. (20558162)	Matej R.... Kovacs G.G.	2010	RAB5A, TARDBP
5	Frontotemporal dementia and motor neurone disease: ov erlapping clinic-pathological disorders. (19556136)	Lillo P.... Hodges J.R.	2009	TARDBP
6	Molecular-targeted therapy for motor neuron disease (19697878)	Banno H.... Sobue G.	2009	SOD1, AR, IGF1
7	Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease. (19655382)	Borroni B.... Padovani A.	2009	TARDBP
8	Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein. (19013502)	Dennis J.S.... Citron B.A.	2009	RPS27A
9	Severe subcortical TDP-43 pathology in sporadic front otemporal lobar degeneration with motor neuron disease. (18004574)	Brandmeir N.J.... Trojanowski J.Q.	2008	TARDBP
10	Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. (18305234)	Laird F.M.... Wong P.C.	2008	DCTN1
11	Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9. (18755042)	Luty A.A.... Schofield P.R.	2008	TARDBP
12	Motor neuron disease and frontotemporal lobar degeneration: a tale of two disorders linked to TDP-43. (18097163)	Elman L.B.... Grossman M.	2008	LOC643387
13	TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. (17492294)	Kwong L.K.... Trojanowski J.Q.	2007	TARDBP
14	Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene. (17549011)	Sasaki S.... Iwata M.	2007	SOD1
15	Elevated levels of transcripts encoding a human retroviral envelope protein (syncytin) in muscles from patients with motor neuron disease. (17453631)	Oluwole S.O.... Karlsson H.	2007	ERVW-1
16	Vitamin E deficiency and risk of equine motor neuron disease. (17605810)	Mohammed H.O.... de Lahunta A.	2007	SOD1
17	A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. (16505168)	Levy J.R.... Holzbaur E.L.	2006	DCTN1
18	Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations. (17079668)	Gowing G.... Julien J.P.	2006	SOD1, TNF
19	Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls. (17116217)	Bilic E.... Zagar M.	2006	IGF1, INS, GH1
20	Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. (17038899)	Xu L.... Koliatsos V.E.	2006	SOD1
21	Ubiquitin-positive inclusions and progression of path ology in frontotemporal dementia and motor neurone disease identifies a group w ith mainly early pathology. (16409556)	Kersaitis C.... Kril J.J.	2006	RPS27A
22	Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementi a of the motor neuron disease type represent a clinicopathologic spectrum. (16106222)	Mackenzie I.R.... Feldman H.H.	2005	RPS27A
23	Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome. (15755678)	Cheroni C.... Bendotti C.	2005	SOD1
24	Denaturing high performance liquid chromatography: high throughput mutation screening in familial hypertrophic cardiomyopathy and SNP genotyping in motor neurone disease. (15858117)	Yu B.... Trent R.J.	2005	MYH7
25	A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13. (15060112)	Nishimura A.L.... Zatz M.	2004	VAPB
26	Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND). (14722583)	Skvortsova V.... Limborska S.	2004	NEFH
27	Dimer destabilization in superoxide dismutase may result in disease- causing properties: structures of motor neuron disease mutants. (15056757)	Hough M.A.... Hasnain S.S.	2004	SOD1
28	Relevance of oxidative injury in the pathogenesis of motor neuron diseases. (14753657)	Agar J.... Durham H.	2003	SOD1
29	PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype. (12651867)	Okuda T.... Okazawa H.	2003	ATXN1
30	Association of homozygosity for short allele (S) of heavy neurofilament subunit gene with motor neuron disease and oxidative stress development (12674703)	Skvortsova V.I.... Botvinko T.M.	2003	SOD1, NEFH
31	Compound heterozygosity with two novel mutations in the HEXB gene produces adult Sandhoff disease presenting as a motor neuron disease phenotype. (11897243)	Yoshizawa T.... Shoji S.	2002	HEXB
32	Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. (11717358)	Nagai M.... Itoyama Y.	2001	SOD1
33	Molecular pathogenesis of motor neuron diseases (11400322)	Sobue G.	2001	AR, HSPA4
34	Motor neuron disease: classification and nomenclature. (11467047)	Swash M.... Desai J.	2000	SOD1
35	Troyer syndrome: a combination of central brain abnormality and motor neuron disease? (10463356)	Auer-Grumbach M.... Hartung H.P.	1999	SPG20
36	Gallyas- and tau-positive glial structures in motor neuron disease with dementia. (10505430)	Noda K.... Nakamura S.	1999	MAPT
37	Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to C NTF and BDNF cotreatment. (9398466)	Ishiyama T.... Mitsumoto H.	1997	BDNF, CNTF
38	Alterations in neural intermediate filament organization: functional implications and the induction of pathological changes related to motor neuron disease. (8886982)	Straube-West K.... Goldman R.D.	1996	NEFH, NEFM
39	Motor neurone disease-inclusion dementia. (9117546)	Jackson M.... Lowe J.	1996	RPS27A
40	Equine motor neuron disease is not linked to Cu/Zn superoxide dismutase mutations: sequence analysis of the equine Cu/Zn superoxide dismutase cDNA. (8921896)	de la Rua-Domenech R.... Batt C.A.	1996	SOD1
41	Motor neuron disease with neurofibrillary tangles in a non-Guamanian patient. (7572072)	Hilton D.A.... Newman P.	1995	RPS27A
42	Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. (8120541)	Ikemoto A.... Hirano A.	1994	SYP
43	Motor neurone disease. (7925318)	Goonetilleke A.... Guiloff R.J.	1994	CNTF
44	Will ciliary neurotrophic factor slow progression of motor neuron disease? (8053646)	Longo F.M.	1994	CNTF
45	Trophic protection of motor neurons: clinical potential in motor neuron diseases. (7699414)	Lindsay R.M.	1994	NGF
46	Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease. (7891897)	Ince P.G.... Markesbery W.R.	1994	SOD1
47	Ubiquitin-positive inclusion in anterior horn cells in subgroups of motor neuron diseases: a comparative study of adult-onset amyotrophic lateral sclerosis, juvenile amyotrophic lateral sclerosis and Werdnig-Hoffmann disease. (8387100)	Matsumoto S.... Hirano A.	1993	RPS27A
48	Kennedy's disease: genetic diagnosis of an inherited form of motor neuron disease. (8517843)	Choi W.T.... Zajac J.D.	1993	AR
49	Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease. (1381416)	Corbo M.... Hays A.P.	1992	INA
50	Ubiquitinated filamentous inclusions in spinal cord o f patients with motor neuron disease. (2166261)	Migheli A.... Schiffer D.	1990	RPS27A

Genes related to motor neuron disease according to GeneCards:

(show top 50)    (show all 87)

id	Symbol	Description	Score	GeneCards Section Context
1	SOD2	superoxide dismutase 2, mitochondrial	11.1	Publications, Summaries
2	SOD1	superoxide dismutase 1, soluble	11.0	Publications
3	SMN2	survival of motor neuron 2, centromeric	11.0	Publications
4	SMN1	survival of motor neuron 1, telomeric	11.0	Publications
5	DCTN1	dynactin 1	11.0	Publications
6	ALS2	amyotrophic lateral sclerosis 2 (juvenile)	11.0	Publications
7	SYP	synaptophysin	11.0	Publications
8	GDNF	glial cell derived neurotrophic factor	11.0	Publications
9	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.0	Publications
10	NEFH	neurofilament, heavy polypeptide	11.0	Publications
11	CNTF	ciliary neurotrophic factor	11.0	Publications
12	HEXB	hexosaminidase B (beta polypeptide)	11.0	Publications
13	CTF1	cardiotrophin 1	11.0	Publications
14	NAIP	NLR family, apoptosis inhibitory protein	11.0	Publications
15	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
16	TARDBP	TAR DNA binding protein	11.0	Publications
17	RPS27A	ribosomal protein S27a	11.0	Publications
18	HEXA	hexosaminidase A (alpha polypeptide)	11.0	Publications
19	PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	11.0	Publications
20	GRN	granulin	11.0	Publications
21	VCP	valosin containing protein	11.0	Publications
22	PVALB	parvalbumin	11.0	Publications
23	RAB5A	RAB5A, member RAS oncogene family	11.0	Publications
24	SQSTM1	sequestosome 1	11.0	Publications
25	SPAST	spastin	11.0	Publications
26	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0	Publications
27	GRIA2	glutamate receptor, ionotropic, AMPA 2	11.0	Publications
28	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	11.0	Publications
29	LIF	leukemia inhibitory factor	11.0	Publications
30	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0	Publications
31	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
32	MAPT	microtubule-associated protein tau	11.0	Publications
33	BDNF	brain-derived neurotrophic factor	11.0	Publications
34	AR	androgen receptor	11.0	Publications
35	GSTT1	glutathione S-transferase theta 1	11.0	Publications
36	HSPA4	heat shock 70kDa protein 4	11.0	Publications
37	MT-TA	mitochondrially encoded tRNA alanine	11.0	Publications
38	LOC643387	TAR DNA binding protein pseudogene	11.0	Publications
39	PNPLA6	patatin-like phospholipase domain containing 6	11.0	Publications
40	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	11.0	Publications
41	RPL28	ribosomal protein L28	11.0	Publications
42	SPG20	spastic paraplegia 20 (Troyer syndrome)	11.0	Publications
43	SIGMAR1	sigma non-opioid intracellular receptor 1	11.0	Publications
44	NEFM	neurofilament, medium polypeptide	11.0	Publications
45	GEMIN2	gem (nuclear organelle) associated protein 2	11.0	Publications
46	PVR	poliovirus receptor	11.0	Publications
47	MAG	myelin associated glycoprotein	11.0	Publications
48	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
49	KIF3B	kinesin family member 3B	11.0	Publications
50	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.0	Publications

Pathways related to motor neuron disease according to GeneDecks:

(show all 12)

id	Pathway	Score	Top Affiliating Genes
1	Pathogenesis of ALS36	10.3	SLC1A2, SLC1A3, SOD1, GRIA2
2	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.1	SOD1, GSTT1, GSTP1, GSTM1
3	Naphthalene metabolism41	9.8	CYP2E1, GSTT1, GSTP1, GSTM1
4	Naphthalene metabolism10	9.8	CYP2E1, GSTT1, GSTP1, GSTM1
5	Phase II conjugation38	9.7	GSTP1, GSTM1, NAT2, NAT1
6	Amyotrophic lateral sclerosis (ALS)20	9.6	NEFM, NEFH, SLC1A2, SOD1, NOS1, TNF
7	Busulfan Pathway, Pharmacodynamics34	9.6	NAT1, NAT2, GSTM1, GSTP1
8	Drug metabolism - cytochrome P45020	9.2	CYP2D6, CYP2E1, GSTT1, GSTP1, GSTM1
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.9	TNF, CALB1, IGF1, APOE, AR
10	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.8	TNF, CALB1, IGF1, APOE, AR
11	Neuroscience3	8.6	RET, NEFM, NEFH, SLC1A2, SLC1A3, SOD1
12	14-3-3 Induced Intracellular Signaling36	8.5	NUDT6, SNCA, TNF, GH1, IGF1, MAPT

Compounds related to motor neuron disease according to GeneDecks:

(show top 50)    (show all 220)

id	Compound	Score	Top Affiliating Genes
1	levodopa32 9 9	12.3	GH1, GDNF, BDNF, RPS27A, SNCA, SOD1
2	silver32	10.1	CALB1, MAPT, CHAT, BSCL2, BDNF, HSPA4
3	n acetylcysteine32	10.1	BDNF, AR, MAPT, SNCA, RPS27A, APOE
4	selegiline32 9 9	11.9	GDNF, BDNF, CYP2E1, SNCA, NGF, SOD1
5	6-hydroxydopamine32	9.9	GDNF, SOD2, NGF, RPS27A, SNCA, CHAT
6	methamphetamine32 9 9	11.8	PVALB, RPS27A, NOS1, SNCA, CYP2D6, CALB1
7	dbc-amp32	9.8	GDNF, NUDT6, SLC1A2, SLC1A3, LIF, BDNF
8	kainate32	9.6	CHAT, BDNF, GRIA2, HSPA4, CALB1, PVALB
9	cocaine32 9 9	11.5	BDNF, CHAT, GDNF, SNCA, SIGMAR1, NGF
10	mptp32	9.3	CALB1, SNCA, NOS1, SOD2, RPS27A, BDNF
11	methionine32	9.2	LIF, HSPA4, GSTT1, RET, NUDT6, BDNF
12	ascorbic acid32 18	10.2	GSTM1, GSTP1, MAG, HSPA4, CYP2E1, NOS1
13	aspartate32	9.2	SLC1A2, GDNF, SOD2, APOE, PVALB, RPS27A
14	choline32 9 18 9	12.1	RET, CNTF, NGF, MAPT, CALB1, SNCA
15	nitric oxide32 9 18 9	12.1	CNTF, NAT1, NAT2, GDNF, SLC1A2, NUDT6
16	4-hydroxynonenal32 18	10.1	GSTM1, CHAT, PON1, GSTP1, APOE, MAPT
17	h2o232	9.1	LIF, SYP, NOS1, SNCA, GH1, MAPT
18	nmda32 42	10.0	GRIA2, HSPA4, NUDT6, APOE, SLC1A3, GDNF
19	superoxide32 18	10.0	SOD1, CNTF, NEFM, NEFH, SLC1A2, PON1
20	alpha tocopherol32	8.8	IGF1, SOD1, APOE, SOD2, PON1, HSPA4
21	lactacystin32	8.6	NOS1, AR, APOE, MAPT, CANX, TNF
22	oligonucleotide32	8.6	NAT1, NAT2, RET, NEFM, LIFR, SMN1
23	norepinephrine32 9 18 9	11.4	CALB1, GDNF, NOS1, SNCA, GH1, CNTF
24	valine32	8.4	ERVW-1, MAPT, APOE, GSTT1, GSTP1, RET
25	glutamate32	8.3	NOS1, RPS27A, PVALB, NUDT6, SLC1A3, SLC1A2
26	paraffin32	8.3	AR, RPS27A, SNCA, GH1, HSPA4, MAPT
27	adenylate32	8.3	AR, CNTF, GSTP1, PABPC1, BDNF, ELAVL4
28	calcium32 9 18 9	11.1	CANX, ERVW-1, VCP, NAIP, CNTF, CALB1
29	creatinine32	8.1	SPG7, CYP2E1, GH1, HSPA4, IGF1, MAPT
30	dopamine32 9 18 9	10.9	SNCA, NOS1, NGF, GFRA1, PVALB, SYP
31	tamoxifen32 34 9 9	10.9	GH1, BDNF, CYP2E1, VEGFA, AR, HSPA4
32	glutamine32	7.8	VCP, GRIA2, APOE, MAPT, IGF1, HSPA4
33	acetylcholine32 9 18 9	10.8	PON1, SOD2, NUDT6, SYP, PVALB, NGF
34	glycerol32 9 18 9	10.8	INS, GSTP1, HSPA4, CANX, GH1, CYP2E1
35	actinomycin d32	7.5	IGF1, SOD2, NGF, RPS27A, GDNF, GH1
36	testosterone32 9 18 9	10.3	SOD2, NUDT6, SYP, NGF, RPS27A, NOS1
37	genistein32 9 18 9	10.1	HSPA4, MAPT, AR, SOD2, LIF, CNTF
38	cycloheximide32	7.0	AR, APOE, MAPT, CANX, CHAT, BDNF
39	estrogen32	6.8	CALB1, NAT2, NOS1, LIFR, BDNF, AR
40	retinoic acid32 42 18	8.6	BDNF, IGF1, INA, GSTP1, MAPT, HSPA4
41	vegf32	6.6	RPS27A, SOD2, RET, GDNF, TNF, GH1
42	dexamethasone32 42 34 9 9	9.9	CYP2D6, NAT2, TNF, CYP2E1, NOS1, RPS27A
43	lipid32	5.9	ERVW-1, GH1, CANX, AMPH, MAG, APOE
44	cysteine32	INF	MAG, MAPT, GRN, GSTP1, GSTM1, UCHL1
45	lactate32	INF	SOD2, BDNF, INS, LIF, GSTM1, GSTP1
46	tyrosine32	INF	SMN1, GDNF, NEFH, SOD2, RPS6, RPS27A
47	glucose32	INF	, CALB1, MT-CO1, NUDT6, SLC1A3, GDNF
48	arginine32	INF	, GH1, ERVW-1, SNCA, SMN1, NOS1
49	serine32	INF	NUDT6, SQSTM1, PON1, SLC1A3, SLC1A2, NEFH
50	alanine32	INF	LIFR, CHAT, ARHGEF2, INS, GSTP1, MAG

Cellular components related to motor neuron disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neurofilament	GO:005883	10.3	INA, NEFH, NEFM
2	growth cone	GO:030426	9.9	SIGMAR1, SNCA, ALS2, MAPT, GRIA2
3	axon	GO:030424	9.7	CNTF, NEFM, NEFH, PVALB, SNCA, CALB1
4	neuronal cell body	GO:043025	9.5	SLC1A3, SOD1, CALB1, ALS2, APOE, ARHGEF2
5	cytosol	GO:005829	7.6	PLEKHG5, SMN2, SNCA, CALB1, HSPA4, NOS1
6	extracellular space	GO:005615	INF	TNF, CTF1, NGF, PVR, SOD1, PON1

Biological processes related to motor neuron disease according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	neurofilament cytoskeleton organization	GO:060052	10.6	NEFM, NEFH, SOD1, INA
2	leukemia inhibitory factor signaling pathway	GO:048861	10.6	LIF, LIFR, CTF1
3	adult walking behavior	GO:007628	10.4	HEXA, MAPT, UCHL1, CHAT
4	negative regulation of neuron apoptotic process	GO:043524	10.3	GDNF, SOD2, SOD1, NGF, SNCA, BDNF
5	response to reactive oxygen species	GO:000302	10.2	MYH7, GSTP1
6	nervous system development	GO:007399	9.8	CTF1, DCTN1, NEFH, SIGMAR1, GDNF, SPG7
7	nerve growth factor receptor signaling pathway	GO:048011	9.6	SQSTM1, NGF, RPS27A, PLEKHG5, MAG, ARHGEF2
8	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.6	AR, IGF1, GH1
9	induction of apoptosis by extracellular signals	GO:008624	9.5	SQSTM1, NGF, RPS27A, PLEKHG5, TNF, ARHGEF2
10	positive regulation of protein complex assembly	GO:031334	9.5	VEGFA, VCP, TNF
11	xenobiotic metabolic process	GO:006805	9.4	CYP2D6, CYP2E1, GSTP1, GSTM1, NAT2, NAT1
12	positive regulation of MAPK cascade	GO:043410	9.1	IGF1, INS, AR, LIF, CNTF
13	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.1	VEGFA, LIF, TNF, SNCA
14	positive regulation of protein autophosphorylation	GO:031954	9.0	VEGFA, INS, NGF
15	cell death	GO:008219	9.0	SETX, SMN2, PNPLA6, HEXA, HEXB, TARDBP
16	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	RPS27A, TNF, INS, AR, ARHGEF2, UBC
17	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	8.6	GH1, IGF1, INS, CNTF
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.4	GH1, IGF1, INS, LIF, VEGFA
19	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.2	GDNF, SQSTM1, HEXB, RPS27A, NOS1, TNF
20	positive regulation of cell proliferation	GO:008284	8.2	NGF, CTF1, IGF1, INS, AR, LIFR
21	anti-apoptosis	GO:006916	8.1	RPS27A, NGF, SQSTM1, SOD1, GDNF, SNCA

Molecular functions related to motor neuron disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	8.1	CNTF, GDNF, NUDT6, NGF, GH1, IGF1
2	protein binding	GO:005515	3.3	RPS6, NOS1, SMN2, SNCA, SPG7, SPAST