Motor Peripheral Neuropathy malady

Genetics Home Reference: Charcot-Marie-Tooth disease is a group of progressive disorders that affect the peripheral nerves and result in problems with movement and sensation. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound.¹⁷

MalaCards: Motor Peripheral Neuropathy, also known as hsmn - hereditary sensory and motor neuropathy, is related to neuropathy and charcot-marie-tooth disease. An important gene associated with Motor Peripheral Neuropathy is NDRG2 (NDRG family member 2), and among its related pathways are Apoptosis and Autophagy and PI3K / Akt Signaling. Affiliated tissues include brain and spinal cord, and related mouse phenotype behavior/neurological.

Aliases & Descriptions:

motor peripheral neuropathy 6 hsmn - hereditary sensory and motor neuropathy 6 hereditary motor and sensory neuropathies 43 hereditary motor and sensory neuropathy 6

hereditary sensory motor neuropathy 32 neuropathic muscular atrophy 6 peripheral motor neuropathy 43 hsmn 6

Diseases related to motor peripheral neuropathy by text searches and GeneDecks gene sharing:

(show all 49)

id	Related Disease	Score	Top Affiliating Genes
1	neuropathy	31.5	KIF1B, MSN, FGD4, TRPV4, DARC, SH3TC2
2	charcot-marie-tooth disease	31.4	NDRG1, SH3TC2, DARC, TRPV4, FGD4, KIF1B
3	hereditary neuropathies	31.4	KIF1B, SH3TC2, NDRG1
4	tooth disease	28.0	NDRG1, SH3TC2, DARC, TRPV4, FGD4, KIF1B
5	motor neuritis	23.3	NDRG1, NDRG2, NDRG3, NDRG4, SLC12A6, SH3TC2
6	charcot-marie-tooth neuropathy type 4	12.3	FGD4, SH3TC2, NDRG1
7	charcot-marie-tooth disease type 4	12.3	NDRG1, SH3TC2, FGD4
8	sensory peripheral neuropathy	12.2	NDRG1, SLC12A6
9	charcot-marie-tooth disease type 2	12.1	KIF1B, TRPV4
10	polyneuropathy	11.7	NDRG1, SH3TC2, MSN, KIF1B
11	charcot-marie-tooth neuropathy	11.0	NDRG1, SH3TC2, TRPV4, FGD4, KIF1B
12	axonal neuropathy	11.0	NDRG1, SH3TC2, TRPV4, FGD4, KIF1B
13	hepatocellular carcinoma	10.8	NDRG3, NDRG2, NDRG1, DARC, MSN, KIF1B
14	agenesis of the corpus callosum with peripheral neuropathy	10.0
15	charcot-marie-tooth neuropathy type 2c	9.7
16	hereditary motor and sensory neuropathy vi	9.7
17	neuronitis	9.6	NDRG4, NDRG2, NDRG1, DARC, TRPV4, MSN
18	peripheral neuropathy	9.1	SLC12A6, KIF1B, MSN, FGD4, TRPV4, DARC
19	charcot-marie-tooth neuropathy type 2	8.8
20	charcot-marie-tooth neuropathy x	8.8
21	sensory neuropathy type 1	8.8
22	charcot-marie-tooth neuropathy type 1	8.8
23	hearing loss	7.9
24	hypertrophic neuropathy of dejerine-sottas	7.9
25	multiple sclerosis	7.9
26	motor sensory neuropathy type 1 aplasia cutis congenita	7.9
27	charcot-marie-tooth disease type 1a	7.9
28	neuropathy, hereditary motor and sensory, lom type	7.9
29	charcot-marie-tooth disease type 1b	7.9
30	neuropathy, hereditary motor and sensory, okinawa type	7.9
31	charcot-marie-tooth disease type 1d	7.9
32	neuropathy, hereditary motor and sensory, russe type	7.9
33	charcot-marie-tooth disease type 2a	7.9
34	optic atrophy	7.9
35	charcot-marie-tooth disease type 2b	7.9
36	paralysis	7.9
37	charcot-marie-tooth disease type 2c	7.9
38	charcot-marie-tooth disease with pyramidal features, autosomal dominant	7.9
39	was-related disorders	7.9
40	charcot-marie-tooth disease x-linked 1	7.9
41	charcot-marie-tooth neuropathy type 1a	7.9
42	charcot-marie-tooth neuropathy type 1b	7.9
43	corpus callosum	7.9
44	cowchock syndrome	7.9
45	motor neuropathy peripheral with dysautonomia	7.7
46	atp7a-related distal motor neuropathy	6.8
47	spinal bulbar motor neuropathy	6.8
48	hereditary spastic paraplegia	5.8
49	refsum disease	5.8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to motor peripheral neuropathy:

²²

MGI Mouse Phenotypes related to motor peripheral neuropathy:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	7.5	KIF1B, TRPV4, SH3TC2, NDRG1, NDRG4, SLC12A6

Genes related to motor peripheral neuropathy according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	NDRG2	NDRG family member 2	11.0
2	SH3TC2	SH3 domain and tetratricopeptide repeats 2	11.0
3	NDRG4	NDRG family member 4	11.0
4	NDRG3	NDRG family member 3	11.0
5	DARC	Duffy blood group, chemokine receptor	11.0
6	NDRG1	N-myc downstream regulated 1	11.0
7	MSN	moesin	11.0
8	FGD4	FYVE, RhoGEF and PH domain containing 4	11.0
9	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6	11.0
10	TRPV4	transient receptor potential cation channel, subfamily V, member 4	11.0
11	KIF1B	kinesin family member 1B	11.0

Pathways related to motor peripheral neuropathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	9.1	NDRG1, NDRG2, NDRG3, NDRG4
2	PI3K / Akt Signaling3	9.0	NDRG1, NDRG2, NDRG3, NDRG4
3	Angiogenesis3	8.8	NDRG4, NDRG3, NDRG2, NDRG1

Cellular components related to motor peripheral neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	filopodium	GO:030175	8.7	MSN, FGD4, TRPV4

Biological processes related to motor peripheral neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peripheral nervous system myelin maintenance	GO:032287	9.8	SH3TC2, NDRG1

Molecular functions related to motor peripheral neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	actin binding	GO:003779	8.7	MSN, FGD4, TRPV4