MCID: MTH009
MIFTS: 50

Mouth Disease malady

Summaries for Mouth Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.

MalaCards: Mouth Disease, also known as mouth disorders, is related to hand, foot and mouth disease and herpangina. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are mTORC1-mediated signalling and Akt Signaling Pathway . The drugs lidocaine and lidocaine hydrochloride and the compounds 2,5-oligoadenylate and m7gtp have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and t cells.

Wikipedia:63 In animal anatomy, the mouth is the opening through which many animals take in food and issue vocal... more...

Aliases & Classifications for Mouth Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

mouth disease 8
mouth disorders 33
mouth diseases 60


External Ids:

Disease Ontology8 DOID:403
MeSH34 D009059

Related Diseases for Mouth Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mouth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hand, foot and mouth disease31.5CA10, CA6, C4A, ANKRD17
2herpangina30.5CA10
3influenza30.1IFNG, TNFSF9, CRAT, EIF4E, EIF4G1
4hepatitis30.0GUSB
5hepatitis b30.0IFNG, CRAT
6viral infectious disease29.7IFNG, GUSB, CRAT, IL10, EIF4B, EIF4E
7arthritis29.7IL10, GUSB, IFNG
8encephalitis10.3
9neurologic diseases10.2
10rhinotracheitis10.2
11pharyngitis10.1
12encephalomyelitis10.1
13lymphopenia10.1
14movement disease10.1
15nail disease10.1
16nervous system disease10.1
17cryptosporidiosis10.0
18swine influenza10.0
19kawasaki disease10.0
20central nervous system disease10.0
21kidney disease10.0
22leukocyte disease10.0
23skin disease10.0
24stomatitis10.0
25colon cancer10.0GUSB
26multiple myeloma10.0CTRL
27gingivitis10.0GUSB
28felty's syndrome10.0C4A
29laryngeal benign neoplasm10.0EIF4G1, EIF4E
30thrombocytopenia10.0GUSB
31herpes simplex10.0EIF4G1, CRAT
32tuberculoid leprosy10.0IL10, IFNG
33nephrotic syndrome10.0GUSB
34lepromatous leprosy10.0IFNG, IL10
35visceral leishmaniasis10.0IL10, IFNG
36pulmonary tuberculosis10.0IFNG, GUSB, IL10
37graves' disease10.0IFNG
38pancreatitis10.0IL10
39cutaneous leishmaniasis10.0IFNG, IL10
40sudden infant death syndrome10.0C4A
41hepatitis c10.0IFNG, IL10, EIF4G1, PTBP1
42hydrocephalus10.0FLNA
43common variable immune deficiency10.0IL10
44prostate cancer10.0CTRL, CRAT, FLNA, EIF4E
45systemic lupus erythematosus10.0IFNG, GUSB, C4A, IL10
46cystic fibrosis10.0GUSB
47breast cancer10.0S1PR3, CTRL, CRAT, EIF4E, EIF4G1
48severe acute respiratory syndrome10.0CTRL
49melanoma10.0IFNG, CTRL, GUSB, CRAT, FLNA, IL10
50leukemia10.0EIF4E, CRAT, GUSB, CTRL, IFNG

Graphical network of the top 20 diseases related to Mouth Disease:



Diseases related to mouth disease

Clinical Features for Mouth Disease

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Drugs & Therapeutics for Mouth Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mouth Disease

Drug clinical trials:

Search ClinicalTrials for Mouth Disease

Search NIH Clinical Center for Mouth Disease

Search CenterWatch for Mouth Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mouth Disease

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Anatomical Context for Mouth Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Mouth Disease:

32
Tongue, Testes, T cells, Skin, Kidney, B cells, Heart, Spleen, Eye, Bone, Salivary gland

Animal Models for Mouth Disease or affiliated genes

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Publications for Mouth Disease

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Sources:
50PubMed
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Articles related to Mouth Disease:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Interleukin-8 is elevated in severe hand, foot, and mouth disease. (24423718)
2014
2
Atypical hand, foot, and mouth disease: a vesiculobullous eruption caused by Coxsackie virus A6. (24287184)
2014
3
Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease. (24374278)
2014
4
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. (24258524)
2013
5
Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. (23454684)
2013
6
Accumulation of nucleotide substitutions occurring during experimental transmission of foot-and-mouth disease virus. (23034594)
2013
7
VP1 B-C and D-E loops of bovine enterovirus cluster B can effectively display foot-and-mouth disease virus type O-conserved neutralizing epitope. (24077365)
2013
8
Reconstructing geographical movements and host species transitions of foot-and-mouth disease virus serotype SAT 2. (24149511)
2013
9
DNA prime-protein boost strategy with replicase-based DNA vaccine against foot-and-mouth disease in bovine calves. (23305616)
2013
10
Years of Epidemics (2009-2011): Pandemic Influenza and Foot-and-Mouth Disease Epidemic in Korea. (24159542)
2013
11
MRI characteristics of brainstem encephalitis in hand-foot-mouth disease induced by enterovirus type 71--will different MRI manifestations be helpful for prognosis? (23561930)
2013
12
Crystal structure of 2A proteinase from hand, foot and mouth disease virus. (23973886)
2013
13
Engineering foot-and-mouth disease viruses with improved growth properties for vaccine development. (23372840)
2013
14
Spatio-Temporal Distribution and Hotspots of Hand, Foot and Mouth Disease (HFMD) in Northern Thailand. (24366049)
2013
15
Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis. (23228860)
2013
16
Epidemiological features of hand-foot-and-mouth disease in Shenzhen, China from 2008 to 2010. (24139426)
2013
17
Decisions on control of foot-and-mouth disease informed using model predictions. (24080392)
2013
18
Laboratory capacity for diagnosis of foot-and-mouth disease in Eastern Africa: implications for the progressive control pathway. (23347795)
2013
19
Novel antiviral therapeutics to control foot-and-mouth disease. (22924938)
2012
20
Generation of monoclonal antibodies against non-structural protein 3AB of foot-and-mouth disease virus. (23055007)
2012
21
Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus. (23028825)
2012
22
Evaluation of human enterovirus 71 and coxsackievirus A16 specific immunoglobulin M antibodies for diagnosis of hand-foot-and-mouth disease. (22234169)
2012
23
Serotype identification and VP1 coding sequence analysis of foot-and-mouth disease viruses from outbreaks in eastern and northern Uganda in 2008/9. (22117844)
2012
24
The characteristics of blood glucose and WBC counts in peripheral blood of cases of hand foot and mouth disease in China: a systematic review. (22235257)
2012
25
Surveillance strategies for foot and mouth disease to prove absence of disease and absence of viral circulation. (23520730)
2012
26
Full genome sequence of a novel coxsackievirus B5 strain isolated from neurological hand, foot, and mouth disease patients in China. (22997425)
2012
27
Risk of foot-and-mouth disease for the Pacific NorthWest economic region. (22151895)
2012
28
Combining livestock trade patterns with phylogenetics to help understand the spread of foot and mouth disease in sub-Saharan Africa, the Middle East and Southeast Asia. (21809754)
2011
29
Reanalysis of the start of the UK 1967 to 1968 foot-and-mouth disease epidemic to calculate airborne transmission probabilities. (21846685)
2011
30
Expression of foot and mouth disease virus nonstructural polyprotein 3ABC with inactive 3C(pro) in Escherichia coli. (21810474)
2011
31
Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease. (22087245)
2011
32
Use of ethnoveterinary remedies in the management of foot and mouth disease lesions in a diary herd. (22238498)
2011
33
Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus. (19369337)
2009
34
Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. (18776092)
2008
35
Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation. (18675807)
2008
36
Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants. (17540462)
2007
37
Cevimeline reduced mouth dryness and increased salivary flow in patients with xerostomia complicating chronic graft-versus-host disease. (16785070)
2006
38
Epidemic of hand, foot and mouth disease in Kawasaki City, Japan. (16249635)
2005
39
Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. (15654079)
2005
40
Deaths in children during an outbreak of hand, foot and mouth disease in Peninsular Malaysia--clinical and pathological characteristics. (16379183)
2005
41
Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore. (12854382)
2003
42
Hand, foot and mouth disease: University Malaya Medical Centre experience. (14569723)
2002
43
Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000). (12516778)
2002
44
Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus. (9426454)
1997
45
Coxsackie B2 virus causing simultaneous hand, foot and mouth disease and encephalitis. (2822814)
1987
46
Electron microscopic demonstration of virus particles in hand, foot and mouth disease. (4076502)
1985
47
Hand, foot and mouth disease: an outbreak with interesting virological features. (4201191)
1973
48
Hand, foot and mouth disease. Light and electron microscopic observations. (4637478)
1972
49
Hand, foot and mouth disease in South Australia. (4301084)
1968
50
HAND, FOOT AND MOUTH DISEASE, 1963-64. A STUDY OF CASES AND FAMILY CONTACTS. (14277587)
1965

Genetic Variations for Mouth Disease

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Expression for genes affiliated with Mouth Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mouth Disease

Search GEO for disease gene expression data for Mouth Disease.

Pathways for genes affiliated with Mouth Disease

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Mouth Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Mouth Disease according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4410.7CRAT
2m7gtp4410.7EIF4G1, EIF4E
3betaseron4410.6IL10, IFNG
4bifidobacterium4410.6GUSB, IL10
5polyinosinic-polycytidylic acid4410.6IFNG, CRAT, IL10
6ribavirin44 49 1112.6IFNG, IL10, EIF4E
7interferon gamma4410.6IL10, IFNG
8pentoxifylline44 1111.5IL10, CRAT, IFNG
9ifn-alpha4410.5EIF4E, IL10, IFNG
10alpha-galactosylceramide4410.5IL10, IFNG
11rapamycin4410.5EIF4G1, EIF4E, EIF4B, IL10, IFNG
12pdtc4410.4IFNG, CTRL, CRAT
134-hydroxynonenal44 2411.4CTRL, GUSB, IL10
14leucine4410.4SCARB2, CTRL, EIF4B, EIF4E, EIF4G1
15tetracycline44 1111.4EIF4E, CRAT, GUSB
16glatiramer acetate44 1111.3IL10, IFNG
17ulinastatin4410.3GUSB
18histamine44 28 2412.2IFNG, CTRL, GUSB, IL10
19atp44 2811.1CTRL, CRAT, EIF4B, EIF4E, EIF4G1, PTBP1
20tuberculin4410.0IL10, IFNG

GO Terms for genes affiliated with Mouth Disease

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16Gene Ontology
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Cellular components related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1IL10, C4A, CTRL, TNFSF9, IFNG, CA6
2eukaryotic translation initiation factor 4F complexGO:01628110.0EIF4G1, EIF4E, EIF4B

Biological processes related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear-transcribed mRNA poly(A) tail shorteningGO:00028910.4EIF4G1, EIF4E, EIF4B
2positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, IFNG
3nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayGO:00028810.3EIF4B, EIF4E, EIF4G1
4modulation by virus of host morphology or physiologyGO:01904810.2EIF4G1, EIF4E, ANKRD17, ITGB6
5inflammatory responseGO:00695410.1S1PR3, C4A, ITGB6, IL10
6negative regulation of growth of symbiont in hostGO:04413010.0IL10, IFNG

Molecular functions related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation initiation factor activityGO:00374310.3EIF4G1, EIF4E, EIF4B

Products for genes affiliated with Mouth Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mouth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet