Mouth Disease malady

MedlinePlus: Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.²³

MalaCards: Mouth Disease, also known as mouth disorders, is related to hand, foot and mouth disease and hepatitis b. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are Translation Regulation activity of EIF4F and Translation_Insulin regulation of translation. The drugs lidocaine and lidocaine hydrochloride and the compounds poly c and leucine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and skin, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia: In animal anatomy, the mouth is the first portion of the alimentary canal that receives food.⁴⁴ more...

Aliases & Descriptions:

mouth disease 6 mouth disorders 23

mouth diseases 43

Diseases related to mouth disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 207)

id	Related Disease	Score	Top Affiliating Genes
1	hand, foot and mouth disease	32.4	SCARB2, FLNA, ANKRD17
2	hepatitis b	21.9	VTN, SCARB2, MX1, ITGB6, GSG2, IL15
3	hepatitis	18.6	VTN, PCBP2, SCARB2, CHKB, MX1, S1PR3
4	periarthritis	13.7	CA10, TRIM47
5	corneal clouding	13.7	FLNA, GUSB, GLB1
6	hermansky-pudlak syndrome	13.4	MX1, IFNB1
7	herpangina	13.4	FLNA, CA10, CA6
8	oral tuberculosis	13.1	IL2, TNF
9	aseptic meningitis	13.1	FLNA, IFNG, CA10, TNF
10	tuberculous uveitis	13.1	IFNG, TNF
11	fetal parainfluenza virus type 3 syndrome	13.1	MX1, IFNA1, IFNB1
12	21-hydroxylase deficiency	13.1	VTN, GUSB, IFNA1, IFNB1
13	bell's palsy	13.1	MX1, IFNA1, TNF
14	takayasu's arteritis	13.0	IL2, TNF, TNFSF4, TNFSF9
15	west nile virus	12.9	MX1, IFNA1, IFNG, TNFSF9
16	parainfluenza virus type 3	12.9	MX1, IL2, IFNA1, IFNB1
17	relapsing-remitting multiple sclerosis	12.9	MX1, IFNA1, IFNB1, IFNG
18	polyradiculoneuropathy	12.8	IL2, IFNB1, IFNG
19	posterior uveitis	12.8	IFNA1, IFNG, TNF
20	lymphatic system disease	12.8	IL2, IFNG, TNF
21	glucocorticoid resistance	12.8	IL2, IFNA1, TNF, CRAT
22	pulmonary plasma cell granuloma	12.8	GUSB, IL15, IFNG, TNF
23	cardiac sarcoidosis	12.8	IL15, IFNG, TNF
24	autoimmune myocarditis	12.8	IL2, IFNG, TNF, TNFSF9
25	venezuelan equine encephalitis	12.7	IFNA1, IFNB1, IFNG
26	multidrug-resistant tuberculosis	12.7	IL2, IFNG, TNF
27	tropical spastic paraparesis	12.7	IL15, IL2, IFNB1, IFNG
28	periapical granuloma	12.7	IL2, IFNG, TNF
29	cutaneous lupus erythematosus	12.7	MX1, IFNA1, IFNG, TNF
30	polymyalgia rheumatica	12.7	MX1, IL2, IFNG, TNF
31	lepromatous leprosy	12.7	IL2, IFNG, TNF
32	sezary's disease	12.7	IL15, IL2, IFNA1, IFNG
33	hemorrhagic fever with renal syndrome	12.7	VTN, IFNG, TNF, DNAH8
34	factor vii deficiency	12.7	IL2, IFNA1, IFNB1, IFNG
35	cryoglobulinemia	12.7	MX1, IFNA1, IFNG, TNF
36	cytomegalovirus retinitis	12.6	IL2, IFNB1, IFNG, TNF
37	avian influenza	12.6	IFNA1, IFNB1, IFNG, TNF
38	chronic progressive multiple sclerosis	12.6	IL2, IFNA1, IFNG, TNF
39	cutaneous t cell lymphoma	12.6	IL15, IL2, IFNA1, IFNG
40	acute graft versus host disease	12.6	IL15, IL2, IFNG, TNF
41	insulinoma	12.6	SEMA6A, CHKB, IL15, TNF, CRAT, ST3GAL4
42	lymphocytic choriomeningitis	12.6	IL2, IFNA1, IFNG, TNF
43	mycobacterial infection	12.5	IL15, IL2, IFNG, TNF
44	t cell deficiency	12.5	IL15, IL2, IFNA1, IFNG, EIF4G1
45	graft versus host disease	12.5	IL15, IL2, IFNG, TNF
46	brucellosis	12.5	IL2, IFNA1, IFNG, TNF
47	serous glue ear	12.5	IL2, IFNA1, IFNG, TNF
48	leukopenia	12.4	GUSB, IL2, IFNA1, IFNG, TNF
49	c4 deficiency	12.4	C4A, C4B
50	cytomegalovirus infection	12.4	ITGAV, ITGB6, IL2, IFNG, TNF, PTBP1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 lidocaine, lidocaine hcl pwdr [va product], lidocaine hydrochloride, lidocaine pwdr [va product]

MalaCards organs/tissues related to mouth disease:

²²

MGI Mouse Phenotypes related to mouth disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	ANKRD17, IFNG, , TNF, TNFSF4, CRAT
2	homeostasis/metabolism phenotype	MP:0005376	INF	VTN, EHHADH, ST3GAL4, , CRAT, TNFSF4
3	cellular phenotype	MP:0005384	INF	TNF, TNFSF4, CRAT, EIF4E, EIF4G2, EIF4G3

Articles related to mouth disease:

(show all 32)

id	Title	Authors	Year	Affiliating Genes
1	Interferon-induced protection against foot-and-mouth disease virus infection correlates with enhanced tissue-specific innate immune cell infiltration and interferon-stimulated gene expression. (19955313)	Diaz-San Segundo F.... Grubman M.J.	2010	IFNG, MX1, IFNA1
2	Recovery of infectious foot-and-mouth disease virus f rom full-length genomic cDNA clones using an RNA polymerase I system. (20011974)	Chang Y.... Liu X.	2009	POLR1C, POLI
3	A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. (19052079)	de los Santos T.... Grubman M.J.	2009	IFNB1
4	Identification of cellular genes affecting the infect ivity of foot-and-mouth disease virus. (19369337)	Piccone M.E.... Cohen S.N.	2009	ENTPD6
5	Comparative analysis of the large fragment of the 5' untranslated region (LF-5' UTR) of serotype A foot-and-mouth disease virus fiel d isolates from India. (19444600)	Mohapatra J.K.... Pattnaik B.	2009	PTBP1
6	Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation. (18675807)	Martinez-Azorin F.... Ballesta J.P.	2008	RPLP2, RPLP1
7	Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. (18776092)	Tunca R.... GokAse E.	2008	CHKB
8	Optimization strategy for plasmid DNAs containing multiple-epitopes of foot-and-mouth disease virus by cis-expression with IL-2. (18191307)	Zhang H.Y.... Wang J.J.	2008	IL2
9	Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus. (18462848)	Wang X.... Wang B.	2008	IL15
10	Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants. (17540462)	Xiao C.... Wang B.	2007	TNFSF4, TNFSF9
11	Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins. (17445855)	Rodriguez Pulido M.... Martinez-Salas E.	2007	PTBP1, EIF3B
12	Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins. (16973584)	Burman A.... Jackson T.	2006	ITGAV, ITGB6
13	The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions. (15885108)	Foeger N.... Skern T.	2005	EIF4G1
14	Constitutive expression of alpha interferon by skin dendritic cells confers resistance to infection by foot-and-mouth disease virus. (15795269)	Bautista E.M.... Golde W.T.	2005	IFNA1
15	Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. (15654079)	Birtley J.R.... Curry S.	2005	CTRL
16	Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site. (15448358)	Strong R.... Belsham G.J.	2004	EIF4G1
17	VP1 of foot-and-mouth disease virus induces apoptosis via the Akt signaling pathway. (15466859)	Peng J.M.... Liang C.M.	2004	S1PR3
18	Sequence and secondary structure requirements in a highly conserved element for foot-and-mouth disease virus internal ribosome entry site activity and eIF4G binding. (15302949)	Bassili G.... Niepmann M.	2004	EIF4G1, EIF4B
19	Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L- protease cleavage site in vitro. (15016848)	Gradi A.... Belsham G.J.	2004	EIF4G2, EIF4G3
20	Foot-and-mouth disease virus leader proteinase: specificity at the P2 and P3 positions and comparison with other papain-like enzymes. (15350134)	Kuehnel E.... Skern T.	2004	EIF4G3
21	Novel viral disease control strategy: adenovirus expressing alpha interferon rapidly protects swine from foot-and-mouth disease. (12502879)	Chinsangaram J.... Grubman M.J.	2003	IFNA1
22	Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site. (11257179)	Saleh L.... Niepmann M.	2001	EIF4G1
23	The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. (11297677)	Donnelly M.L.... Ryan M.D.	2001	GUSB
24	Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. (11287565)	Miller L.C.... Jackson T.	2001	DNAH8
25	Replication-competent foot-and-mouth disease virus RNAs lacking capsid coding sequences. (10859374)	McInerney G.M.... Belsham G.J.	2000	CRAT
26	The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. (10799568)	Jackson T.... King A.M.	2000	ITGAV, ITGB6
27	Interaction of eukaryotic initiation factor eIF4B with the internal ribosome entry site of foot-and-mouth disease virus is independent of the polypyrimidine tract-binding protein. (10364367)	Rust R.C.... Niepmann M.	1999	EIF4B, PTBP1
28	Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition. (9857201)	Guarne A.... Skern T.	1998	EIF4G1
29	Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus. (9426454)	Sharma A.... Stuart D.I.	1997	VTN
30	Bacterial synthesis of immunogenic epitopes of foot-and-mouth disease virus fused either to human necrosis factor or to hepatitis B core antigen (9157845)	Nekrasova O.V.... Korobko V.G.	1997	TNF
31	A recombinant, arginine-glycine-aspartic acid (RGD) motif from foot-and-mouth disease virus binds mammalian cells through vitronectin and, to a lower extent, fibronectin receptors. (8973352)	Villaverde A.... Coutelle C.	1996	VTN
32	Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma. (8057448)	Kirchweger R.... Rhoads R.E.	1994	EIF4G1

Genes related to mouth disease according to GeneCards:

(show top 50)    (show all 54)

id	Symbol	Description	Score	GeneCards Section Context
1	SCARB2	scavenger receptor class B, member 2	11.1	Summaries
2	ANKRD17	ankyrin repeat domain 17	11.0	Functions
3	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	11.0	Publications
4	EIF4B	eukaryotic translation initiation factor 4B	11.0	Publications
5	PTBP1	polypyrimidine tract binding protein 1	11.0	Publications
6	FLNA	filamin A, alpha	11.0
7	CRAT	carnitine O-acetyltransferase	11.0	Publications
8	EIF4E	eukaryotic translation initiation factor 4E	11.0
9	GUSB	glucuronidase, beta	11.0	Publications
10	CA10	carbonic anhydrase X	11.0
11	SEBOX	SEBOX homeobox	11.0
12	SAT2	spermidine/spermine N1-acetyltransferase family member 2	11.0
13	TRIM47	tripartite motif containing 47	11.0
14	CBX8	chromobox homolog 8	11.0
15	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13	11.0
16	GSG2	germ cell associated 2 (haspin)	11.0
17	RNASEH2A	ribonuclease H2, subunit A	11.0
18	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	11.0
19	EXOSC4	exosome component 4	11.0
20	RPLP2	ribosomal protein, large, P2	11.0	Publications
21	RPLP1	ribosomal protein, large, P1	11.0	Publications
22	S1PR3	sphingosine-1-phosphate receptor 3	11.0	Publications
23	POLI	polymerase (DNA directed) iota	11.0	Publications
24	CTRL	chymotrypsin-like	11.0	Publications
25	ENTPD6	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	11.0	Publications
26	TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	11.0	Publications
27	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	11.0	Publications
28	GOLPH3	golgi phosphoprotein 3 (coat-protein)	11.0
29	FAM48A	family with sequence similarity 48, member A	11.0
30	EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	11.0
31	ITGB6	integrin, beta 6	11.0	Proteins, Publications
32	PALM2	paralemmin 2	11.0
33	POLR1C	polymerase (RNA) I polypeptide C, 30kDa	11.0	Publications
34	ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	11.0
35	TACR2	tachykinin receptor 2	11.0
36	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	11.0
37	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
38	GLB1	galactosidase, beta 1	11.0
39	FRS2	fibroblast growth factor receptor substrate 2	11.0
40	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	11.0	Publications
41	EIF3B	eukaryotic translation initiation factor 3, subunit B	11.0	Publications
42	ITGAV	integrin, alpha V	11.0	Publications, Proteins
43	CHKB	choline kinase beta	11.0	Publications
44	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	11.0	Publications
45	VTN	vitronectin	11.0	Publications
46	HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	11.0
47	PCBP2	poly(rC) binding protein 2	11.0
48	DNAH8	dynein, axonemal, heavy chain 8	11.0	Publications
49	IL15	interleukin 15	11.0	Publications
50	IFNB1	interferon, beta 1, fibroblast	11.0	Publications

Pathways related to mouth disease according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Translation Regulation activity of EIF4F10	10.4	EIF4G3, EIF4G1
2	Translation_Insulin regulation of translation41	10.2	EIF4G3, EIF4G1, EIF4E, EIF4B
3	Translation Insulin regulation of translation10	10.2	EIF4G3, EIF4G1, EIF4E, EIF4B
4	Translation _Regulation of EIF4F activity41	10.0	EIF4G3, EIF4G2, EIF4G1, EIF4E, EIF4B
5	Translational Control3	9.9	PTBP1, EIF4B, EIF4E, EIF4G1, EIF4G2
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL2, IL15
7	RNA transport20	9.7	EIF4G3, EIF4G2, EIF4G1, EIF4E, EIF4B, EIF3B
8	mTOR Pathway36	9.5	EIF4G3, EIF4G2, EIF4G1, EIF4E, EIF4B, IL2
9	Regulation of eIF4 and p70S6K36	8.8	EIF4G3, EIF4G2, EIF4G1, EIF4E, IL2, IL15
10	MIF Mediated Glucocorticoid Regulation36	8.6	TNFSF9, TNFSF4, TNF, IL2, IL15
11	MIF Regulation of Innate Immune Cells36	8.6	TNFSF9, TNFSF4, TNF, IL2, IL15
12	Akt Signaling36	8.5	ITGB6, IL15, IL2, TNF, TNFSF9
13	PEDF Induced Signaling36	8.4	IL15, IL2, TNF, TNFSF4, TNFSF9
14	Measles20	8.2	IFNG, IFNB1, IFNA1, IL2, MX1
15	all-trans-Retinoic Acid Signaling in Brain36	8.1	TNFSF9, TNFSF4, TNF, IL2, IL15
16	Cytokine Network36	7.4	IL15, TNF, IFNG, IFNB1, IFNA1, IL2
17	Cytokine-cytokine receptor interaction20	7.1	TNFSF9, TNFSF4, TNF, IFNG, IFNB1, IFNA1

Compounds related to mouth disease according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	poly c32	9.8	PTBP1, IFNB1, PCBP2
2	leucine32	9.7	EHHADH, EIF4G1, EIF4E, EIF4B, CTRL, MAFF
3	rebif32	9.6	IFNB1, IFNA1, MX1
4	avonex32	9.6	MX1, IFNA1, IFNB1
5	rapamycin32 42	10.5	EIF4G1, EIF4E, IFNG, IL2
6	alpha-galactosylceramide32	9.3	IFNG, IL2, IL15
7	cycloferon32	9.3	IFNG, IFNA1
8	mezerein32	9.1	IFNG, IFNB1, IFNA1
9	kynurenine32	9.1	IFNA1, IFNB1, IFNG
10	betaseron32	9.1	IFNG, IFNB1, IFNA1, MX1
11	interferon gamma32	9.0	IL2, IFNG, TNF
12	taurine chloramine32	8.9	TNF, IFNG, IL2
13	acyclovir32	8.8	IFNG, IFNB1, IFNA1
14	glatiramer acetate32 9 9	10.8	IL2, IFNA1, IFNB1, IFNG
15	gold sodium thiomalate32	8.7	IL2, IFNG, TNF
16	okt332	8.6	TNF, IFNG, IL2, IL15
17	gm-csf32	8.5	TNF, IFNG, IL2, IL15
18	ribavirin32 34 9 9	11.5	EIF4E, IFNG, IFNB1, IFNA1, IL2, MX1
19	ifn-alpha32	8.5	EIF4E, IFNG, IFNB1, IFNA1, IL2, MX1
20	indoleamine32	8.4	TNF, IFNG, IFNB1, IFNA1
21	cisplatin32 34 9 9	11.4	POLR1C, EIF4G1, EIF4E, CRAT, IFNB1, IFNA1
22	imiquimod32 42 9 9	11.3	TNF, IFNG, IFNB1, IFNA1, MX1
23	il 1032	8.1	TNF, IFNG, IFNB1, IL2, IL15
24	glucosamine32 9 18 9	11.1	ST3GAL4, TNF, IFNG, IL2
25	tamoxifen32 34 9 9	11.1	DNAH8, CRAT, CTRL, IFNB1, IFNA1, IL2
26	superoxide32 18	9.1	ST3GAL4, TACR2, CTRL, TNF, IFNB1, IL15
27	thalidomide32 42 9 9	11.1	TNF, IFNG, IFNA1, IL2, VTN
28	ccl332	8.0	TNF, IFNG, IFNB1, IFNA1, IL15
29	il-1232	8.0	TNF, IFNG, IFNA1, IL2, IL15
30	histamine32 18	9.0	TACR2, CTRL, TNF, IFNG, IL2, IL15
31	poly(i-c)32	7.9	TNF, IFNG, IFNB1, IFNA1, IL15, MX1
32	chloroquine32 34 9 9	10.8	TNF, IFNB1, IFNA1, IL2, IL15, VTN
33	prednisolone32 9 9	9.7	DNAH8, TNF, IFNG, IFNA1, IL2, CHKB
34	2,5-oligoadenylate32	7.7	CRAT, TNF, IFNG, IFNB1, IFNA1, IL2
35	neopterin32	7.5	TNF, IFNG, IFNB1, IFNA1, IL2, MX1
36	polyinosinic-polycytidylic acid32	7.5	IL15, CRAT, TNF, IFNG, IFNB1, IFNA1
37	actinomycin d32	7.4	POLR1C, TACR2, EIF4E, CRAT, TNF, IFNG
38	tacrolimus32 34 9 9	10.4	TNF, IFNG, IFNA1, IL2, IL15, CHKB
39	rantes32	7.3	TNF, IFNG, IFNB1, IFNA1, IL2, IL15
40	pge232	7.2	TACR2, CRAT, TNF, IFNG, IFNB1, IL2
41	cyclosporin a32 42	8.1	TACR2, DNAH8, TNF, IFNG, IFNA1, IL2
42	thymidine32 18	7.9	CRAT, TNF, GLB1, IFNG, IFNB1, IFNA1
43	cycloheximide32	6.7	POLR1C, EIF4G1, EIF4E, CRAT, TNF, IFNG
44	atp32	INF	POLR1C, DNAH8, EIF4G1, EIF4E, EIF4B, CRAT
45	serine32	INF	CTRL, CRAT, , , EIF4E, POLR1C
46	vegf32	INF	EIF4G1, EIF4E, CRAT, TNF, , IFNG
47	arginine32	INF	ST3GAL4, TACR2, DNAH8, EIF4G1, , CRAT
48	tyrosine32	INF	IFNB1, , HNRNPU, CTRL, EIF4B, EIF4E
49	alanine32	INF	, EIF4E, EIF4G1, DNAH8, TACR2, IFNB1
50	retinoic acid32 42 18	INF	EIF4E, CRAT, CTRL, TNF, , IFNG

Cellular components related to mouth disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	INF	TNFSF4, TNFSF9, CTRL, , TNF, IFNG
2	eukaryotic translation initiation factor 4F complex	GO:016281	9.5	EIF4B, EIF4E, EIF4G1, EIF4G2, EIF4G3

Biological processes related to mouth disease according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO:000288	10.2	EIF4G1, EIF4E, EIF4B, EXOSC4
2	translational initiation	GO:006413	10.0	EIF4G1, EIF4E, EIF4B, EIF3B, RPLP1, RPLP2
3	nuclear-transcribed mRNA poly(A) tail shortening	GO:000289	10.0	EIF4G1, EIF4E, EIF4B
4	regulation of translational initiation	GO:006446	9.8	EIF3B, EIF4B, EIF4G1, EIF4G2, EIF4G3
5	translation	GO:006412	9.8	RPLP2, RPLP1, EIF3B, EIF4B, EIF4E, EIF4G1
6	mRNA metabolic process	GO:016071	9.7	EIF4G1, EIF4E, EIF4B, RPLP1, RPLP2, EXOSC4
7	RNA metabolic process	GO:016070	9.7	EIF4G3, EIF4G2, EIF4G1, EIF4E, EIF4B, RPLP1
8	positive regulation of vitamin D biosynthetic process	GO:060557	9.1	IFNG, TNF
9	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.0	IFNG, TNF
10	gene expression	GO:010467	9.0	POLR1C, EIF4G1, EIF4E, EIF4B, EIF3B, RPLP1
11	cytokine-mediated signaling pathway	GO:019221	8.8	EIF4G3, EIF4G2, EIF4G1, EIF4E, IFNG, IFNB1
12	response to virus	GO:009615	8.1	TNFSF4, TNF, IFNG, IFNB1, MX1, PCBP2

Molecular functions related to mouth disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	translation factor activity, nucleic acid binding	GO:008135	9.9	EIF4G1, EIF4G2, EIF4G3
2	translation initiation factor activity	GO:003743	9.5	EIF3B, EIF4B, EIF4E, EIF4G1, EIF4G2, EIF4G3
3	cytokine activity	GO:005125	7.4	TNFSF9, TNFSF4, TNF, IFNG, IFNB1, IL2
4	RNA binding	GO:003723	INF	, EIF4B, RNASEH2A, RPLP1, RPLP2, PTBP1