MCID: MTH009
MIFTS: 47

Mouth Disease malady

Oral diseases category
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Summaries for Mouth Disease

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.

MalaCards: Mouth Disease, also known as mouth disorders, is related to hand, foot and mouth disease and herpangina. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are Lysosome and Pertussis. The drugs lidocaine and lidocaine hydrochloride and the compounds bifidobacterium and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and t cells.

Wikipedia:65 In animal anatomy, the mouth, also known as the oral cavity, buccal cavity, or in Latin cavum oris, is... more...

Aliases & Classifications for Mouth Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

mouth disease 8
mouth disorders 34
mouth diseases 62


External Ids:

Disease Ontology8 DOID:403
MeSH35 D009059

Related Diseases for Mouth Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mouth Disease:



Diseases related to mouth disease

Symptoms for Mouth Disease

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Drugs & Therapeutics for Mouth Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Mouth Disease

Search NIH Clinical Center for Mouth Disease

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Mouth Disease

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Anatomical Context for Mouth Disease

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Sources:
33MalaCards
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MalaCards organs/tissues related to Mouth Disease:

33
Tongue, Testes, T cells, Kidney, Skin, Spleen, Heart, B cells

Animal Models for Mouth Disease or affiliated genes

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Publications for Mouth Disease

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Sources:
52PubMed
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Articles related to Mouth Disease:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Interleukin-8 is elevated in severe hand, foot, and mouth disease. (24423718)
2014
2
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. (24074589)
2013
3
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. (24258524)
2013
4
Dynamic impacts of a catastrophic production event: the foot-and-mouth disease case. (23078069)
2013
5
The Population-Based Health Effect of Hand, Foot and Mouth Disease in Children in Shanghai. (24153009)
2013
6
Hand, foot, and mouth disease: current scenario and Indian perspective. (23442455)
2013
7
Epidemiology and etiological characteristics of hand, foot and mouth disease in Huizhou City between 2008 and 2011. (23229012)
2013
8
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China. (23497074)
2013
9
Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. (23454684)
2013
10
Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells. (23740480)
2013
11
Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar. (23830685)
2013
12
Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysis. (23194776)
2013
13
Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009. (23341722)
2013
14
Brazilian foot and mouth disease status and meat exportation to the European Union. (24338447)
2013
15
Accumulation of nucleotide substitutions occurring during experimental transmission of foot-and-mouth disease virus. (23034594)
2013
16
A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection. (23963534)
2013
17
Foot-and-Mouth Disease in Pigs: Current Epidemiological Situation and Control Methods. (22225815)
2012
18
A survey on the frequency of foot-and-mouth disease virus carriers in cattle in north-east of Iran by RT-PCR: implications for revising disease control strategy. (22222047)
2012
19
Serological and clinical surveillance studies to validate reported foot-and-mouth disease free status in Tsirang district of Bhutan. (22172605)
2012
20
Coxsackievirus B5, associated with neurological hand, foot and mouth disease, China. (22484273)
2012
21
Upconversion nanoparticles modified with aminosilanes as carriers of DNA vaccine for foot-and-mouth disease. (22476264)
2012
22
Vaccination against foot-and-mouth disease II: Regaining FMD-free status. (22726463)
2012
23
Genetic characterization of a new pandemic Southeast Asia topotype strain of serotype O foot-and-mouth disease virus isolated in China during 2010. (21932049)
2012
24
A safe foot-and-mouth disease vaccine platform with two negative markers for differentiating infected from vaccinated animals. (22915802)
2012
25
The therapeutic effect of Tarentula cubensis extract (TheranekronAr) in foot-and-mouth disease in cattle: a randomised trial in an endemic setting. (22818233)
2012
26
United approach to foot-and-mouth disease. (23173229)
2012
27
Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. (22964289)
2012
28
A capture-recapture analysis in a challenging environment: assessing the epidemiological situation of foot-and-mouth disease in Cambodia. (22225773)
2012
29
Novel antiviral therapeutics to control foot-and-mouth disease. (22924938)
2012
30
Cationic microparticle [poly(D,L-lactide-co-glycolide)]-coated DNA vaccination induces a long-term immune response against foot and mouth disease in guinea pigs. (22438260)
2012
31
An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). (22387223)
2012
32
Expression and stability of foreign epitopes introduced into 3A nonstructural protein of foot-and-mouth disease virus. (22848509)
2012
33
Experimental foot-and-mouth disease virus infection in white tailed deer. (22520809)
2012
34
Outbreak of hand, foot and mouth disease caused by Coxsackie A16 virus in a childcare centre in Croatia, February to March 2011. (21632018)
2011
35
Evaluation of sentinel surveillance system for monitoring hand, foot and mouth disease in Hong Kong. (22036193)
2011
36
Comparative study of codon substitution patterns in foot-and-mouth disease virus (serotype O). (21825834)
2011
37
Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. (22239028)
2011
38
Hand, Foot and Mouth Disease in Yunnan Province, China, 2008-2010. (22199158)
2011
39
Analysis of the acute phase responses of Serum Amyloid A, Haptoglobin and Type 1 Interferon in cattle experimentally infected with foot-and-mouth disease virus serotype O. (21592356)
2011
40
Developing vaccines against foot-and-mouth disease and some other exotic viral diseases of livestock. (21893540)
2011
41
The codon usage model of the context flanking each cleavage site in the polyprotein of foot-and-mouth disease virus. (21801856)
2011
42
Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection. (22020303)
2011
43
Letter to the editor. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection. (20565298)
2010
44
Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. (18776092)
2008
45
FactSheet: hand, foot and mouth disease. (12806411)
2003
46
Foot and mouth disease in livestock and reduced cryptosporidiosis in humans, England and Wales. (12533277)
2003
47
Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. (12042582)
2002
48
The serological response to foot-and-mouth disease vaccination is not affected by simultaneous infectious bovine rhinotracheitis/adenovirus/parainfluenza 3 vaccination. (2549906)
1989
49
Hand, foot and mouth disease. (4525203)
1974
50
Foot-and-mouth disease, pasteurellosis, parasitic diseases. (5750257)
1968

Variations for Mouth Disease

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Expression for genes affiliated with Mouth Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mouth Disease

Search GEO for disease gene expression data for Mouth Disease.

Pathways for genes affiliated with Mouth Disease

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Sources:
50PathCards, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 53QIAGEN
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Pathways related to Mouth Disease according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SCARB2, GUSB
29.4C4A, IL10
39.4C4A, IL10
4
Show member pathways
9.2EIF4E, EIF4G1
5
Show member pathways
9.2EIF4E, EIF4G1
69.2EIF4E, EIF4G1
79.2EIF4E, EIF4G1
8
Show member pathways
9.2EIF4G1, EIF4E
99.2EIF4E, EIF4G1
10
Show member pathways
Development Activation of ERK by Alpha 1 adrenergic receptors60
9.2EIF4G1, EIF4E
11
Show member pathways
9.0C4A, EIF4G1, IL10
12
Show member pathways
8.7IL10, EIF4G1, EIF4E

Compounds for genes affiliated with Mouth Disease

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Mouth Disease according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1bifidobacterium459.6IL10, GUSB
2ulinastatin459.6IL10, GUSB
3ketamine45 29 1111.6IL10, GUSB
4m7gtp459.5EIF4E, EIF4G1
5ribavirin45 51 1111.3EIF4E, IL10
64-hydroxynonenal45 2410.3GUSB, IL10
7guanosine45 24 1111.3EIF4E, EIF4G1
8ifn-alpha459.3EIF4E, IL10
9zidovudine45 51 1111.0IL10, GUSB
10leucine459.0SCARB2, EIF4G1, EIF4E
11tetracycline45 119.9EIF4E, GUSB
12rapamycin458.9IL10, EIF4G1, EIF4E
13ly294002458.9EIF4E, EIF4G1, IL10
14cycloheximide458.7EIF4E, EIF4G1, IL10
15vegf458.7EIF4E, EIF4G1, IL10

GO Terms for genes affiliated with Mouth Disease

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Sources:
16Gene Ontology
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Cellular components related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:0432029.5SCARB2, GUSB
2eukaryotic translation initiation factor 4F complexGO:0162819.1EIF4E, EIF4G1
3extracellular vesicular exosomeGO:0700627.9EIF4E, CA6, SCARB2, GUSB

Biological processes related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translational initiationGO:0064139.2EIF4E, EIF4G1
2nuclear-transcribed mRNA poly(A) tail shorteningGO:0002899.1EIF4E, EIF4G1
3nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayGO:0002888.9EIF4E, EIF4G1

Molecular functions related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation initiation factor activityGO:0037439.2EIF4E, EIF4G1

Products for genes affiliated with Mouth Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mouth Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet