MCID: MTH009
MIFTS: 45

Mouth Disease malady

Summaries for Mouth Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.

MalaCards: Mouth Disease, also known as mouth disorders, is related to herpangina and hand, foot and mouth disease. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are Akt Signaling Pathway and Translation initiation complex formation. The drugs lidocaine and lidocaine hydrochloride and the compounds 2,5-oligoadenylate and m7gtp have been mentioned in the context of this disorder.

Wikipedia:64 In animal anatomy, the mouth is the opening through which many animals take in food and issue vocal... more...

Aliases & Classifications for Mouth Disease

Sources:
8Disease Ontology, 34MedlinePlus, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
See all sources

Aliases & Descriptions:

mouth disease 8
mouth disorders 34
mouth diseases 61


External Ids:

Disease Ontology8 DOID:403
MeSH35 D009059

Related Diseases for Mouth Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mouth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1herpangina30.6CA10
2hand, foot and mouth disease30.4CA6, ANKRD17, C4A, CA10
3hepatitis b30.0IFNG, CRAT
4hepatitis c30.0IFNG, IL10, PTBP1, EIF4G1
5viral infectious disease29.8GUSB, IFNG, CRAT, IL10, EIF4B, EIF4E
6arthritis29.8IFNG, GUSB, IL10
7rhinotracheitis10.2
8cryptosporidiosis10.0
9swine influenza10.0
10hepatitis e10.0
11hepatitis d10.0
12kawasaki disease10.0
13hepatitis a10.0
14brain disease10.0
15stomatitis10.0
16devic disease10.0
17hepatitis c virus10.0
18hepatitis10.0GUSB
19colon cancer10.0GUSB
20multiple myeloma10.0CTRL
21gingivitis10.0GUSB
22felty's syndrome10.0C4A
23laryngeal carcinoma10.0EIF4G1, EIF4E
24thrombocytopenia10.0GUSB
25herpes simplex10.0CRAT, EIF4G1
26tuberculoid leprosy10.0IFNG, IL10
27nephrotic syndrome10.0GUSB
28lepromatous leprosy10.0IL10, IFNG
29visceral leishmaniasis10.0IL10, IFNG
30pulmonary tuberculosis10.0IFNG, GUSB, IL10
31graves' disease10.0IFNG
32pancreatitis10.0IL10
33cutaneous leishmaniasis10.0IL10, IFNG
34sudden infant death syndrome10.0C4A
35hydrocephalus10.0FLNA
36common variable immune deficiency10.0IL10
37prostate cancer10.0CRAT, FLNA, CTRL, EIF4E
38influenza10.0IFNG, EIF4G1, EIF4E, CRAT, TNFSF9
39systemic lupus erythematosus10.0IFNG, C4A, GUSB, IL10
40cystic fibrosis10.0GUSB
41breast cancer10.0EIF4E, EIF4G1, CRAT, S1PR3, CTRL
42severe acute respiratory syndrome10.0CTRL
43melanoma10.0GUSB, CTRL, EIF4E, IL10, IFNG, CRAT
44leukemia10.0IFNG, CTRL, GUSB, EIF4E, CRAT
45ipex syndrome10.0EIF4G1, IL10, CRAT, C4A, CTRL, GUSB
46multiple sclerosis10.0IL10, IFNG, TNFSF9
47burning mouth syndrome9.9
48cholera9.9
49tick-borne encephalitis9.9
50pulmonary edema9.9

Graphical network of the top 20 diseases related to Mouth Disease:



Diseases related to mouth disease

Clinical Features for Mouth Disease

Drugs & Therapeutics for Mouth Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mouth Disease

Drug clinical trials:

Search ClinicalTrials for Mouth Disease

Search NIH Clinical Center for Mouth Disease

Search CenterWatch for Mouth Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Mouth Disease

Anatomical Context for Mouth Disease

Animal Models for Mouth Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mouth Disease

Sources:
51PubMed
See all sources

Articles related to Mouth Disease:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Detection and Seroprevalence of Foot and Mouth Disease in Sheep and Goats in Punjab, Pakistan. (24393420)
2014
2
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China. (23497074)
2013
3
Enterovirus genotypes causing hand foot and mouth disease in Shanghai, China: a molecular epidemiological analysis. (24148902)
2013
4
The economic impacts of foot and mouth disease - what are they, how big are they and where do they occur? (23958457)
2013
5
Serological responses after vaccination of growing pigs with foot-and-mouth disease trivalent (type O, A and Asia1) vaccine. (23490554)
2013
6
Venezuelan equine encephalitis replicon particles can induce rapid protection against foot-and-mouth disease virus. (23468490)
2013
7
Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity. (23174161)
2013
8
Onychomadesis following hand, foot, and mouth disease: a case report from Italy and review of the literature. (22417170)
2013
9
Transient gene expression in serum-free suspension-growing mammalian cells for the production of foot-and-mouth disease virus empty capsids. (23977353)
2013
10
Display of the VP1 epitope of foot-and-mouth disease virus on bacteriophage T7 and its application in diagnosis. (23933075)
2013
11
Genetic diversity of serotype A foot-and-mouth disease viruses in Kenya from 1964 to 2013; implications for control strategies in eastern Africa. (24368254)
2013
12
Estimation of the Infection Window for the 2010/2011 Korean Foot-and-Mouth Disease Outbreak. (24159543)
2013
13
Improving the efficacy of conventional therapy by adding andrographolide sulfonate in the treatment of severe hand, foot, and mouth disease: a randomized controlled trial. (23401711)
2013
14
Severe hand, foot and mouth disease in Shenzhen, South China: what matters most? (23809877)
2013
15
Low birth weight is associated with lower respiratory tract infections in children with hand, foot, and mouth disease. (24273920)
2013
16
Specific primer amplification of the VP1 region directed by 5' UTR sequence analysis: enterovirus testing and identification in clinical samples from hand-foot-and-mouth disease patients. (23769858)
2013
17
A survey on the frequency of foot-and-mouth disease virus carriers in cattle in north-east of Iran by RT-PCR: implications for revising disease control strategy. (22222047)
2012
18
Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. (22964289)
2012
19
A capture-recapture analysis in a challenging environment: assessing the epidemiological situation of foot-and-mouth disease in Cambodia. (22225773)
2012
20
Immunodiagnosis of foot-and-mouth disease using mutated recombinant 3ABC polyprotein in a competitive ELISA. (22683829)
2012
21
Evaluation of the solid phase competition ELISA for detecting antibodies against the six foot-and-mouth disease virus non-O serotypes. (22561986)
2012
22
The foot and mouth disease network in the southern cone of South America: an example of regional governance. (23413740)
2012
23
Circulation of multiple enterovirus serotypes causing hand, foot and mouth disease in India. (22052995)
2012
24
Clinical characteristics of hand, foot and mouth disease in Harbin and the prediction of severe cases. (22613598)
2012
25
Modulation of cytokine mRNA expression in pharyngeal epithelial samples obtained from cattle infected with foot-and-mouth disease virus. (21868026)
2012
26
Virus survival in slurry: analysis of the stability of foot-and-mouth disease, classical swine fever, bovine viral diarrhoea and swine influenza viruses. (22226541)
2012
27
Emergence of antigenic variants with in serotype A foot and mouth disease virus in India and evaluation of a new vaccine candidate panel. (22445197)
2012
28
An ELISA based on the repeated foot-and-mouth disease virus 3B epitope peptide can distinguish infected and vaccinated cattle. (22207215)
2012
29
Recombination of human coxsackievirus B5 in hand, foot, and mouth disease patients, China. (22305307)
2012
30
Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008-2011. (22652041)
2012
31
Serosurveillance for foot-and-mouth disease in Mongolian gazelles (Procapra gutturosa) and livestock on the Eastern Steppe of Mongolia. (22247371)
2012
32
Comparative study of codon substitution patterns in foot-and-mouth disease virus (serotype O). (21825834)
2011
33
Foot and mouth disease model verification and 'relative validation' through a formal model comparison. (21961223)
2011
34
Echovirus 30 in EV71-associated hand, foot and mouth disease outbreak, Guangxi, China. (21306942)
2011
35
Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA. (21813609)
2011
36
Surveillance of hand, foot, and mouth disease in mainland China (2008-2009). (22108323)
2011
37
Reducing animal experimentation in foot-and-mouth disease vaccine potency tests. (21640777)
2011
38
Molecular characterization of serotype Asia-1 foot-and-mouth disease viruses in Pakistan and Afghanistan; emergence of a new genetic Group and evidence for a novel recombinant virus. (21983559)
2011
39
Validation of a recombinant integrin I+vI^6/monoclonal antibody based antigen ELISA for the diagnosis of foot-and-mouth disease. (21635921)
2011
40
Identification of H-2d restricted T cell epitope of foot-and-mouth disease virus structural protein VP1. (21896206)
2011
41
Development of a serotype colloidal gold strip using monoclonal antibody for rapid detection type Asia1 foot-and-mouth disease. (21880157)
2011
42
Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany. (19941005)
2010
43
A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. (19052079)
2009
44
The tale of a modern animal plague: tracing the evolutionary history and determining the time-scale for foot and mouth disease virus. (18945462)
2008
45
Hand, foot and mouth disease in an immunocompromised adult treated with aciclovir. (12869047)
2003
46
Bovine herpesvirus-1 (infectious bovine rhinotracheitis virus)-based viral vector which expresses foot-and-mouth disease epitopes. (1722936)
1991
47
Modified-live infectious bovine rhinotracheitis virus (IBRV) vaccine expressing foot-and-mouth disease virus (FMDV) capsid protein epitopes on surface of hybrid virus particles. (1725233)
1991
48
The serological response to foot-and-mouth disease vaccination is not affected by simultaneous infectious bovine rhinotracheitis/adenovirus/parainfluenza 3 vaccination. (2549906)
1989
49
Hand, foot and mouth disease in south Wales, 1964. (6027194)
1967
50
DISEASES OF THE MOUTH; DIFFERENTIAL DIAGNOSIS. II. GINGIVITIS, STOMATITIS, GINGIVOSTOMATITIS AND CHEILITIS. (14133077)
1964

Genetic Variations for Mouth Disease

Expression for genes affiliated with Mouth Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mouth Disease

Search GEO for disease gene expression data for Mouth Disease.

Pathways for genes affiliated with Mouth Disease

Sources:
53R&D Systems, 54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
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Compounds for genes affiliated with Mouth Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Mouth Disease according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4510.7CRAT
2m7gtp4510.7EIF4E, EIF4G1
3betaseron4510.6IFNG, IL10
4bifidobacterium4510.6GUSB, IL10
5polyinosinic-polycytidylic acid4510.6CRAT, IFNG, IL10
6ribavirin45 50 1112.6EIF4E, IL10, IFNG
7interferon gamma4510.6IL10, IFNG
8pentoxifylline45 1111.5IL10, CRAT, IFNG
9ifn-alpha4510.5EIF4E, IL10, IFNG
10alpha-galactosylceramide4510.5IFNG, IL10
11rapamycin4510.5EIF4E, EIF4G1, EIF4B, IL10, IFNG
12pdtc4510.4CTRL, CRAT, IFNG
134-hydroxynonenal45 2411.4GUSB, CTRL, IL10
14leucine4510.4SCARB2, CTRL, EIF4B, EIF4E, EIF4G1
15tetracycline45 1111.4CRAT, EIF4E, GUSB
16tuberculin4510.3IFNG, IL10
17ulinastatin4510.3GUSB
18histamine45 29 2412.2IL10, GUSB, IFNG, CTRL
19atp45 2911.1CRAT, EIF4G1, EIF4E, PTBP1, EIF4B, CTRL
20glatiramer acetate45 1111.0IFNG, IL10

GO Terms for genes affiliated with Mouth Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1IL10, C4A, CTRL, TNFSF9, IFNG, CA6
2eukaryotic translation initiation factor 4F complexGO:01628110.0EIF4G1, EIF4E, EIF4B

Biological processes related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear-transcribed mRNA poly(A) tail shorteningGO:00028910.4EIF4G1, EIF4E, EIF4B
2positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, IFNG
3nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayGO:00028810.3EIF4G1, EIF4E, EIF4B
4modulation by virus of host morphology or physiologyGO:01904810.2EIF4E, ANKRD17, EIF4G1, ITGB6
5inflammatory responseGO:00695410.1C4A, IL10, S1PR3, ITGB6
6negative regulation of growth of symbiont in hostGO:04413010.0IL10, IFNG

Molecular functions related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation initiation factor activityGO:00374310.3EIF4G1, EIF4E, EIF4B

Products for genes affiliated with Mouth Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mouth Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet