MCID: MTH009
MIFTS: 50

Mouth Disease malady

Summaries for Mouth Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.

MalaCards: Mouth Disease, also known as mouth disorders, is related to hand, foot and mouth disease and herpangina. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are mTORC1-mediated signalling and Akt Signaling Pathway . The drugs lidocaine and lidocaine hydrochloride and the compounds 2,5-oligoadenylate and m7gtp have been mentioned in the context of this disorder. Affiliated tissues include tongue, t cells and testes.

Wikipedia:63 In animal anatomy, the mouth is the opening through which many animals take in food and issue vocal... more...

Aliases & Classifications for Mouth Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

mouth disease 8
mouth disorders 33
mouth diseases 60


External Ids:

Disease Ontology8 DOID:403
MeSH34 D009059

Related Diseases for Mouth Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mouth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hand, foot and mouth disease31.5CA10, CA6, C4A, ANKRD17
2herpangina30.5CA10
3influenza30.1IFNG, TNFSF9, CRAT, EIF4E, EIF4G1
4hepatitis30.0GUSB
5hepatitis b30.0IFNG, CRAT
6viral infectious disease29.7IFNG, GUSB, CRAT, IL10, EIF4B, EIF4E
7arthritis29.7IL10, GUSB, IFNG
8encephalitis10.3
9neurologic diseases10.2
10rhinotracheitis10.2
11pharyngitis10.1
12encephalomyelitis10.1
13lymphopenia10.1
14movement disease10.1
15nail disease10.1
16nervous system disease10.1
17cryptosporidiosis10.0
18swine influenza10.0
19kawasaki disease10.0
20central nervous system disease10.0
21kidney disease10.0
22leukocyte disease10.0
23skin disease10.0
24stomatitis10.0
25colon cancer10.0GUSB
26multiple myeloma10.0CTRL
27gingivitis10.0GUSB
28felty's syndrome10.0C4A
29laryngeal benign neoplasm10.0EIF4G1, EIF4E
30thrombocytopenia10.0GUSB
31herpes simplex10.0EIF4G1, CRAT
32tuberculoid leprosy10.0IL10, IFNG
33nephrotic syndrome10.0GUSB
34lepromatous leprosy10.0IFNG, IL10
35visceral leishmaniasis10.0IL10, IFNG
36pulmonary tuberculosis10.0IFNG, GUSB, IL10
37graves' disease10.0IFNG
38pancreatitis10.0IL10
39cutaneous leishmaniasis10.0IFNG, IL10
40sudden infant death syndrome10.0C4A
41hepatitis c10.0IFNG, IL10, EIF4G1, PTBP1
42hydrocephalus10.0FLNA
43common variable immune deficiency10.0IL10
44prostate cancer10.0CTRL, CRAT, FLNA, EIF4E
45systemic lupus erythematosus10.0IFNG, GUSB, C4A, IL10
46cystic fibrosis10.0GUSB
47breast cancer10.0S1PR3, CTRL, CRAT, EIF4E, EIF4G1
48severe acute respiratory syndrome10.0CTRL
49melanoma10.0IFNG, CTRL, GUSB, CRAT, FLNA, IL10
50leukemia10.0EIF4E, CRAT, GUSB, CTRL, IFNG

Graphical network of the top 20 diseases related to Mouth Disease:



Diseases related to mouth disease

Clinical Features for Mouth Disease

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Drugs & Therapeutics for Mouth Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mouth Disease

Drug clinical trials:

Search ClinicalTrials for Mouth Disease

Search NIH Clinical Center for Mouth Disease

Search CenterWatch for Mouth Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Mouth Disease

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Anatomical Context for Mouth Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Mouth Disease:

32
Tongue, T cells, Testes, Skin, Kidney, B cells, Salivary gland, Heart, Spleen, Bone, Eye

Animal Models for Mouth Disease or affiliated genes

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Publications for Mouth Disease

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Sources:
50PubMed
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Articles related to Mouth Disease:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Chitosan-based systems for intranasal immunization against foot-and-mouth disease. (23379822)
2014
2
RNA structure disrupting G320-T transversion within the short fragment of the 5' untranslated region prevents rescue of infectious foot-and-mouth disease virus. (24269793)
2014
3
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. (24074589)
2013
4
Epidemiology and etiological characteristics of hand, foot and mouth disease in Huizhou City between 2008 and 2011. (23229012)
2013
5
Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysis. (23194776)
2013
6
Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009. (23341722)
2013
7
First confirmation of foot and mouth disease virus serotype SAT-1 in cattle and small ruminants in Ethiopia in 2007/08. (23250672)
2013
8
Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand, foot and mouth disease. (24316007)
2013
9
Development and evaluation of multiplex RT-LAMP assays for rapid and sensitive detection of foot-and-mouth disease virus. (23583488)
2013
10
Sequence analysis of the foot and mouth disease virus type O/IRN/2007 VP1 gene from Iranian isolate. (23746175)
2013
11
Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues affecting virus stability. (23717387)
2013
12
Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401. (22984928)
2013
13
The value of animal movement tracing: a case study simulating the spread and control of foot-and-mouth disease in California. (23260796)
2013
14
Prevalence of enteroviruses in children with and without hand, foot, and mouth disease in China. (24370001)
2013
15
Characterization of a type O foot-and-mouth disease virus re-emerging in the year 2011 in free areas of the Southern Cone of South America and cross-protection studies with the vaccine strain in use in the region. (23182909)
2013
16
Delivery of synthetic RNA can enhance the immunogenicity of vaccines against foot-and-mouth disease virus (FMDV) in mice. (23859841)
2013
17
The performance of approximations of farm contiguity compared to contiguity defined using detailed geographical information in two sample areas in Scotland: implications for foot-and-mouth disease modelling. (24099627)
2013
18
Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71. (23961958)
2013
19
Transient gene expression in serum-free suspension-growing mammalian cells for the production of foot-and-mouth disease virus empty capsids. (23977353)
2013
20
Display of the VP1 epitope of foot-and-mouth disease virus on bacteriophage T7 and its application in diagnosis. (23933075)
2013
21
Genetic diversity of serotype A foot-and-mouth disease viruses in Kenya from 1964 to 2013; implications for control strategies in eastern Africa. (24368254)
2013
22
Estimation of the Infection Window for the 2010/2011 Korean Foot-and-Mouth Disease Outbreak. (24159543)
2013
23
Improving the efficacy of conventional therapy by adding andrographolide sulfonate in the treatment of severe hand, foot, and mouth disease: a randomized controlled trial. (23401711)
2013
24
Severe hand, foot and mouth disease in Shenzhen, South China: what matters most? (23809877)
2013
25
Low birth weight is associated with lower respiratory tract infections in children with hand, foot, and mouth disease. (24273920)
2013
26
Specific primer amplification of the VP1 region directed by 5' UTR sequence analysis: enterovirus testing and identification in clinical samples from hand-foot-and-mouth disease patients. (23769858)
2013
27
Expression and stability of foreign epitopes introduced into 3A nonstructural protein of foot-and-mouth disease virus. (22848509)
2012
28
Complete genome sequence of a recombinant coxsackievirus B4 from a patient with a fatal case of hand, foot, and mouth disease in Guangxi, China. (22966193)
2012
29
Capsid coding sequences of foot-and-mouth disease viruses are determinants of pathogenicity in pigs. (22624592)
2012
30
Enteroviruses in patients experiencing multiple episodes of hand, foot, and mouth disease in the same season in Kobe, Japan, 2011. (22996228)
2012
31
Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype. (22513388)
2012
32
The 2010 foot-and-mouth disease epidemic in Japan. (22075710)
2012
33
Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway. (22993157)
2012
34
Foot-and-Mouth Disease Virus Serotype O Phylodynamics: Genetic Variability Associated with Epidemiological Factors in Pakistan. (22846206)
2012
35
Detection of foot-and-mouth disease serotype O by ELISA using a monoclonal antibody. (23244327)
2012
36
Serosurveillance for foot-and-mouth disease in Mongolian gazelles (Procapra gutturosa) and livestock on the Eastern Steppe of Mongolia. (22247371)
2012
37
Evaluation of sentinel surveillance system for monitoring hand, foot and mouth disease in Hong Kong. (22036193)
2011
38
Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection. (22020303)
2011
39
Proteomics analysis of porcine serum proteins by LC-MS/MS after foot-and-mouth disease virus (FMDV) infection. (21799299)
2011
40
Effect of mouth opening on bypass function after combined revascularization for Moyamoya disease. (21691985)
2011
41
Full-mouth rehabilitation of a patient with gastroesophageal reflux disease: a clinical report. (22003881)
2011
42
The infectivity and pathogenicity of a foot-and-mouth disease virus persistent infection strain from oesophageal-pharyngeal fluid of a Chinese cattle in 2010. (22166050)
2011
43
Development of a serotype colloidal gold strip using monoclonal antibody for rapid detection type Asia1 foot-and-mouth disease. (21880157)
2011
44
A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. (19052079)
2009
45
Disease dynamics over very different time-scales: foot-and-mouth disease and scrapie on the network of livestock movements in the UK. (17698478)
2007
46
Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. (12533285)
2003
47
Hand, foot and mouth disease in an immunocompromised adult treated with aciclovir. (12869047)
2003
48
Nail matrix arrest in the course of hand, foot and mouth disease. (11760019)
2001
49
Bovine herpesvirus-1 (infectious bovine rhinotracheitis virus)-based viral vector which expresses foot-and-mouth disease epitopes. (1722936)
1991
50
Modified-live infectious bovine rhinotracheitis virus (IBRV) vaccine expressing foot-and-mouth disease virus (FMDV) capsid protein epitopes on surface of hybrid virus particles. (1725233)
1991

Genetic Variations for Mouth Disease

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Expression for genes affiliated with Mouth Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mouth Disease

Search GEO for disease gene expression data for Mouth Disease.

Pathways for genes affiliated with Mouth Disease

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Mouth Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Mouth Disease according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4410.7CRAT
2m7gtp4410.7EIF4G1, EIF4E
3betaseron4410.6IL10, IFNG
4bifidobacterium4410.6GUSB, IL10
5polyinosinic-polycytidylic acid4410.6IFNG, CRAT, IL10
6ribavirin44 49 1112.6IFNG, IL10, EIF4E
7interferon gamma4410.6IL10, IFNG
8pentoxifylline44 1111.5IL10, CRAT, IFNG
9ifn-alpha4410.5EIF4E, IL10, IFNG
10alpha-galactosylceramide4410.5IL10, IFNG
11rapamycin4410.5EIF4G1, EIF4E, EIF4B, IL10, IFNG
12pdtc4410.4IFNG, CTRL, CRAT
134-hydroxynonenal44 2411.4CTRL, GUSB, IL10
14leucine4410.4SCARB2, CTRL, EIF4B, EIF4E, EIF4G1
15tetracycline44 1111.4EIF4E, CRAT, GUSB
16glatiramer acetate44 1111.3IL10, IFNG
17ulinastatin4410.3GUSB
18histamine44 28 2412.2IFNG, CTRL, GUSB, IL10
19atp44 2811.1CTRL, CRAT, EIF4B, EIF4E, EIF4G1, PTBP1
20tuberculin4410.0IL10, IFNG

GO Terms for genes affiliated with Mouth Disease

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16Gene Ontology
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Cellular components related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1IL10, C4A, CTRL, TNFSF9, IFNG, CA6
2eukaryotic translation initiation factor 4F complexGO:01628110.0EIF4G1, EIF4E, EIF4B

Biological processes related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear-transcribed mRNA poly(A) tail shorteningGO:00028910.4EIF4G1, EIF4E, EIF4B
2positive regulation of MHC class II biosynthetic processGO:04534810.3IL10, IFNG
3nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayGO:00028810.3EIF4B, EIF4E, EIF4G1
4modulation by virus of host morphology or physiologyGO:01904810.2EIF4G1, EIF4E, ANKRD17, ITGB6
5inflammatory responseGO:00695410.1S1PR3, C4A, ITGB6, IL10
6negative regulation of growth of symbiont in hostGO:04413010.0IL10, IFNG

Molecular functions related to Mouth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation initiation factor activityGO:00374310.3EIF4G1, EIF4E, EIF4B

Products for genes affiliated with Mouth Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mouth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet