MCID: MTH009
MIFTS: 43

Mouth Disease malady

Oral diseases category

Summaries for Mouth Disease

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MedlinePlus:32 Your mouth is one of the most important parts of your body. any problem that affects your mouth can make it hard to eat, drink or even smile. some common mouth problems include cold sores - painful sores on the lips and around the mouth, caused by a virus canker sores - painful sores in the mouth, caused by bacteria or viruses thrush - a yeast infection that causes white patches in your mouth leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers dry mouth - a lack of enough saliva, caused by some medicines and certain diseases gum or tooth problems bad breath treatment for mouth disorders varies, depending on the problem. keeping a clean mouth by brushing and flossing often is important.

MalaCards based summary: Mouth Disease, also known as mouth disorders, is related to hand, foot and mouth disease and herpangina. An important gene associated with Mouth Disease is SCARB2 (scavenger receptor class B, member 2), and among its related pathways are Lysosome and Pertussis. The drugs lidocaine and lidocaine hydrochloride and the compounds bifidobacterium and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include the mouth, tongue and testes.

Disease Ontology:9 A gastrointestinal system disease that is located in the mouth.

Aliases & Classifications for Mouth Disease

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Mouth Disease, Aliases & Descriptions:

Name: Mouth Disease 9
Mouth Disorders 32
 
Mouth Diseases 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology9 DOID:403
MeSH33 D009059

Related Diseases for Mouth Disease

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Graphical network of the top 20 diseases related to Mouth Disease:



Diseases related to mouth disease

Symptoms for Mouth Disease

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Drugs & Therapeutics for Mouth Disease

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Drug clinical trials:

Search ClinicalTrials for Mouth Disease

Search NIH Clinical Center for Mouth Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Mouth Disease

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Anatomical Context for Mouth Disease

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MalaCards organs/tissues related to Mouth Disease:

31
Tongue, Testes, T cells, Skin, Kidney, Spleen, Heart, B cells

FMA organs/tissues related to Mouth Disease:

14
The mouth

Animal Models for Mouth Disease or affiliated genes

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Publications for Mouth Disease

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Articles related to Mouth Disease:

(show top 50)    (show all 687)
idTitleAuthorsYear
1
Foot-and-Mouth Disease in Red Deer - Experimental Infection and Test Methods Performance. (25907028)
2015
2
Epidemiological characteristics and temporal-spatial clustering analysis of hand, foot and mouth disease in Nanchang city 2008-2012. (25400030)
2014
3
Interleukin-8 is elevated in severe hand, foot, and mouth disease. (24423718)
2014
4
Epididymitis caused by coxsackievirus a6 in association with hand, foot, and mouth disease. (25232161)
2014
5
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. (24074589)
2013
6
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. (24258524)
2013
7
Dynamic impacts of a catastrophic production event: the foot-and-mouth disease case. (23078069)
2013
8
The Population-Based Health Effect of Hand, Foot and Mouth Disease in Children in Shanghai. (24153009)
2013
9
Hand, foot, and mouth disease: current scenario and Indian perspective. (23442455)
2013
10
Epidemiology and etiological characteristics of hand, foot and mouth disease in Huizhou City between 2008 and 2011. (23229012)
2013
11
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China. (23497074)
2013
12
Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. (23454684)
2013
13
Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells. (23740480)
2013
14
Surveillance of foot-and-mouth disease (FMD) in susceptible wildlife and domestic ungulates in Southeast of Bulgaria following a FMD case in wild boar. (23830685)
2013
15
Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysis. (23194776)
2013
16
Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009. (23341722)
2013
17
Brazilian foot and mouth disease status and meat exportation to the European Union. (24338447)
2013
18
Accumulation of nucleotide substitutions occurring during experimental transmission of foot-and-mouth disease virus. (23034594)
2013
19
A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection. (23963534)
2013
20
Foot-and-Mouth Disease in Pigs: Current Epidemiological Situation and Control Methods. (22225815)
2012
21
A survey on the frequency of foot-and-mouth disease virus carriers in cattle in north-east of Iran by RT-PCR: implications for revising disease control strategy. (22222047)
2012
22
Serological and clinical surveillance studies to validate reported foot-and-mouth disease free status in Tsirang district of Bhutan. (22172605)
2012
23
Coxsackievirus B5, associated with neurological hand, foot and mouth disease, China. (22484273)
2012
24
Upconversion nanoparticles modified with aminosilanes as carriers of DNA vaccine for foot-and-mouth disease. (22476264)
2012
25
Vaccination against foot-and-mouth disease II: Regaining FMD-free status. (22726463)
2012
26
Genetic characterization of a new pandemic Southeast Asia topotype strain of serotype O foot-and-mouth disease virus isolated in China during 2010. (21932049)
2012
27
A safe foot-and-mouth disease vaccine platform with two negative markers for differentiating infected from vaccinated animals. (22915802)
2012
28
The therapeutic effect of Tarentula cubensis extract (TheranekronAr) in foot-and-mouth disease in cattle: a randomised trial in an endemic setting. (22818233)
2012
29
United approach to foot-and-mouth disease. (23173229)
2012
30
Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. (22964289)
2012
31
A capture-recapture analysis in a challenging environment: assessing the epidemiological situation of foot-and-mouth disease in Cambodia. (22225773)
2012
32
Novel antiviral therapeutics to control foot-and-mouth disease. (22924938)
2012
33
An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). (22387223)
2012
34
Expression and stability of foreign epitopes introduced into 3A nonstructural protein of foot-and-mouth disease virus. (22848509)
2012
35
Outbreak of hand, foot and mouth disease caused by Coxsackie A16 virus in a childcare centre in Croatia, February to March 2011. (21632018)
2011
36
Evaluation of sentinel surveillance system for monitoring hand, foot and mouth disease in Hong Kong. (22036193)
2011
37
Comparative study of codon substitution patterns in foot-and-mouth disease virus (serotype O). (21825834)
2011
38
Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. (22239028)
2011
39
Hand, Foot and Mouth Disease in Yunnan Province, China, 2008-2010. (22199158)
2011
40
Analysis of the acute phase responses of Serum Amyloid A, Haptoglobin and Type 1 Interferon in cattle experimentally infected with foot-and-mouth disease virus serotype O. (21592356)
2011
41
Developing vaccines against foot-and-mouth disease and some other exotic viral diseases of livestock. (21893540)
2011
42
The codon usage model of the context flanking each cleavage site in the polyprotein of foot-and-mouth disease virus. (21801856)
2011
43
Letter to the editor. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection. (20565298)
2010
44
Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. (18776092)
2008
45
FactSheet: hand, foot and mouth disease. (12806411)
2003
46
Foot and mouth disease in livestock and reduced cryptosporidiosis in humans, England and Wales. (12533277)
2003
47
Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. (12042582)
2002
48
The serological response to foot-and-mouth disease vaccination is not affected by simultaneous infectious bovine rhinotracheitis/adenovirus/parainfluenza 3 vaccination. (2549906)
1989
49
Hand, foot and mouth disease. (4525203)
1974
50
Foot-and-mouth disease, pasteurellosis, parasitic diseases. (5750257)
1968

Variations for Mouth Disease

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Expression for genes affiliated with Mouth Disease

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Search GEO for disease gene expression data for Mouth Disease.

Pathways for genes affiliated with Mouth Disease

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Pathways related to Mouth Disease according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SCARB2, GUSB
29.4C4A, IL10
39.4C4A, IL10
4
Show member pathways
9.2EIF4E, EIF4G1
5
Show member pathways
9.2EIF4E, EIF4G1
69.2EIF4E, EIF4G1
79.2EIF4E, EIF4G1
8
Show member pathways
9.2EIF4G1, EIF4E
99.2EIF4E, EIF4G1
10
Show member pathways
Development Activation of ERK by Alpha 1 adrenergic receptors58
9.2EIF4G1, EIF4E
11
Show member pathways
9.0C4A, EIF4G1, IL10
12
Show member pathways
8.7IL10, EIF4G1, EIF4E

Compounds for genes affiliated with Mouth Disease

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Sources:
43Novoseek, 28IUPHAR, 12DrugBank, 49PharmGKB, 24HMDB
See all sources

Compounds related to Mouth Disease according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1bifidobacterium439.6IL10, GUSB
2ulinastatin439.6IL10, GUSB
3ketamine43 28 1211.6IL10, GUSB
4m7gtp439.5EIF4E, EIF4G1
5ribavirin43 49 1211.3EIF4E, IL10
64-hydroxynonenal43 2410.3GUSB, IL10
7guanosine43 24 1211.3EIF4E, EIF4G1
8ifn-alpha439.3EIF4E, IL10
9zidovudine43 49 1211.0IL10, GUSB
10leucine439.0SCARB2, EIF4G1, EIF4E
11tetracycline43 129.9EIF4E, GUSB
12rapamycin438.9IL10, EIF4G1, EIF4E
13ly294002438.9EIF4E, EIF4G1, IL10
14cycloheximide438.7EIF4E, EIF4G1, IL10
15vegf438.7EIF4E, EIF4G1, IL10

GO Terms for genes affiliated with Mouth Disease

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Cellular components related to Mouth Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal lumenGO:00432029.5SCARB2, GUSB
2eukaryotic translation initiation factor 4F complexGO:00162819.1EIF4E, EIF4G1
3extracellular vesicular exosomeGO:00700627.9EIF4E, CA6, SCARB2, GUSB

Biological processes related to Mouth Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1translational initiationGO:00064139.2EIF4E, EIF4G1
2nuclear-transcribed mRNA poly(A) tail shorteningGO:00002899.1EIF4E, EIF4G1
3nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayGO:00002888.9EIF4E, EIF4G1

Molecular functions related to Mouth Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1translation initiation factor activityGO:00037439.2EIF4E, EIF4G1

Products for genes affiliated with Mouth Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Mouth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet