MCID: MYM002
MIFTS: 60

Moyamoya Disease malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Moyamoya Disease

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Sources:
50OMIM, 11Disease Ontology, 46NIH Rare Diseases, 24Genetics Home Reference, 47NINDS, 13DISEASES, 52Orphanet, 25GTR, 12diseasecard, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet, 60SNOMED-CT, 62The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Moyamoya Disease:

Name: Moyamoya Disease 50 11 46 24 47 13 52 12 48 37 66
Moyamoya Disease 1 46 25 66
Spontaneous Occlusion of the Circle of Willis 46 24
Progressive Intracranial Arterial Occlusion 11 24
Moyamoya Disease 3 46 66
Moyamoya Disease 2 46 66
Moya-Moya Disease 24 25
 
Progressive Intracranial Occlusive Arteropathy 24
Cerebrovascular Moyamoya Disease 24
Moyamoya Disease, Secondary 46
Moyamoya Disease, Primary 46
Moyamoya Syndrome 46
Mymy 46

Characteristics:

Orphanet epidemiological data:

52
moyamoya disease:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial,X-linked recessive; Prevalence: 1-9/1000000 (France); Age of onset: All ages

HPO:

62
moyamoya disease:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM50 252350
Disease Ontology11 DOID:13099
ICD1028 I67.5
ICD9CM30 437.5
MeSH37 D009072
SNOMED-CT60 69116000, 89142007
NCIt43 C84895
Orphanet52 ORPHA2573
UMLS via Orphanet67 C0026654, C2931384
ICD10 via Orphanet29 I67.5
MESH via Orphanet38 C536991, D009072

Summaries for Moyamoya Disease

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NIH Rare Diseases:46 Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. the name "moyamoya" means "puff of smoke" in japanese and describes the look of the tangled vessels that form to compensate for the blockage. this condition usually affects children, but can affect adults. affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (tias) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. researchers believe that moyamoya disease is an inherited condition because it tends to run in families.moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, sturge-weber syndrome, and tuberous sclerosis. last updated: 7/1/2014

MalaCards based summary: Moyamoya Disease, also known as moyamoya disease 1, is related to myocardial infarction and moyamoya disease 5, and has symptoms including seizures, ventriculomegaly and cognitive impairment. An important gene associated with Moyamoya Disease is RNF213 (Ring Finger Protein 213), and among its related pathways are Syndecan-1-mediated signaling events and Cell adhesion_Cell-matrix glycoconjugates. Affiliated tissues include brain, testes and endothelial, and related mouse phenotypes are muscle and respiratory system.

Disease Ontology:11 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. blood flow is blocked by the constriction and also by blood clots.

NINDS:47 Moyamoya disease is a rare, progressive cerebrovascular disorder caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name ?moyamoya? means ?puff of smoke? in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage.

Genetics Home Reference:24 Moyamoya disease is a disorder of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. These vessels, which provide oxygen-rich blood to the brain, narrow over time. Narrowing of these vessels reduces blood flow in the brain. In an attempt to compensate, new networks of small, fragile blood vessels form. These networks, visualized by a particular test called an angiogram, resemble puffs of smoke, which is how the condition got its name: "moyamoya" is an expression meaning "something hazy like a puff of smoke" in Japanese.

OMIM:50 Moyamoya is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion... (252350) more...

Wikipedia:69 Moyamoya Disease is a disease in which certain arteries in the brain are constricted. Blood flow is... more...

Related Diseases for Moyamoya Disease

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Diseases in the Moyamoya Disease family:

Moyamoya Disease 3 Moyamoya Disease 5
Moyamoya Disease 2

Diseases related to Moyamoya Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction28.7GUCY1A3, MMP3, MMP9, MTHFR, TGFB1, VEGFA
2moyamoya disease 512.2
3moyamoya disease 212.2
4moyamoya disease 312.2
5moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism12.1
6moyamoya 6 with achalasia11.8
7rhizomelic dysplasia, scoliosis, and retinitis pigmentosa10.8MMP3, MMP9
8pathological gambling10.7MMP3, MMP9
9central core myopathy10.7ACTA2, GUCY1A3, RNF213
10acute salpingo-oophoritis10.6ACTA2, GUCY1A3, RNF213
11diamond-blackfan anemia10.6MMP9, TGFB1
12cerebritis10.6
13pineal region yolk sac tumor10.6MMP3, MMP9, TIMP2
14schwannomatosis10.6MMP3, MMP9, TIMP2
15thrombocytosis10.6FGF2, TGFB1
16pericardial mesothelioma10.6FGF2, TGFB1
17emphysematous cholecystitis10.5MMP9, VEGFA
18impetigo herpetiformis10.5MMP3, MMP9, TIMP2
19colorectal adenoma10.5FGF2, VEGFA
20ameloblastic carcinoma10.5MMP9, MTHFR
21intestinal benign neoplasm10.5MMP9, TIMP2, VEGFA
22adenosine monophosphate deaminase 1 deficiency10.5MMP9, TIMP2, VEGFA
23keratopathy10.5TGFB1, TIMP2
24chorioretinitis10.5MMP3, MMP9, VEGFA
25vertebral artery occlusion10.5MMP3, MMP9, VEGFA
26granulomatous orchitis10.5FGF2, MMP3, TGFB1
27hydromyelia10.4MTHFR, VEGFA
28exudative vitreoretinopathy 110.4FGF2, TGFB1, TIMP2
29malignant giant cell tumor10.4MMP3, MMP9, VEGFA
30hemopneumothorax10.4MMP9, VEGFA
31plague10.4MMP3, MMP9
32neuropathy, hereditary sensory and autonomic, type vi10.4FGF2, MMP9, VEGFA
33vitreous abscess10.4FGF2, TGFB1, VEGFA
34scrotum paget's disease10.4FGF2, TGFB1
35dysostosis10.3MMP9, TGFB1, VEGFA
36immunodeficiency 27b, mycobacteriosis, ad10.3MMP3, MMP9
37dental pulp disease10.3FGF2, TGFB1, VEGFA
38aneurysm10.3
39gallbladder papillomatosis10.3MMP9, TGFB1, VEGFA
40villous adenoma10.3MMP9, TGFB1, VEGFA
41oral lichen planus10.2MMP9, MTHFR, VEGFA
42lobular neoplasia10.2MMP9, TGFB1, TIMP2, VEGFA
43pseudoxanthoma elasticum10.2
44naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.2FGF2, TGFB1, TIMP2, VEGFA
45littre gland carcinoma10.2ACTA2, MMP9, MTHFR
46brachyolmia10.2MMP9, TGFB1, VEGFA
47seminal vesicle tumor10.2MMP9, VEGFA
48autoimmune hepatitis10.2MMP3, MMP9, TGFB1, VEGFA
49lung hilum cancer10.1MMP3, MMP9, MTHFR, TIMP2
50gemistocytic astrocytoma10.1FGF2, MMP9, TGFB1, VEGFA

Graphical network of the top 20 diseases related to Moyamoya Disease:



Diseases related to moyamoya disease

Symptoms for Moyamoya Disease

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Symptoms by clinical synopsis from OMIM:

252350

Clinical features from OMIM:

252350

Symptoms:

 52
  • telangiectasia
  • intellectual disability
  • seizures
  • ventriculomegaly
  • abnormality of the cerebral vasculature

HPO human phenotypes related to Moyamoya Disease:

(show all 6)
id Description Frequency HPO Source Accession
1 seizures typical (50%) HP:0001250
2 ventriculomegaly typical (50%) HP:0002119
3 cognitive impairment typical (50%) HP:0100543
4 abnormality of the cerebral vasculature typical (50%) HP:0100659
5 telangiectasia HP:0001009
6 inflammatory arteriopathy HP:0005291

Drugs & Therapeutics for Moyamoya Disease

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Drugs for Moyamoya Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
XylometazolinePhase 370526-36-35709
Synonyms:
 
Balminil
Xylomethazoline
2Xenon62
3
Sevoflurane45328523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
4
GlucosamineNutraceutical1653416-24-8439213
Synonyms:
(+)-2-amino-2-deoxy-D-glucopyranose
(2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(2S,5R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
14257-69-3
2-Amino-2-deoxy-D-Glucose
2-Amino-2-deoxy-D-glucopyranose
2-Amino-2-deoxy-D-glucose
2-Amino-2-deoxy-beta-D-glucopyranose
2-Amino-2-deoxyglucose
2-Aminoglucose
2-Deoxy-2-amino-D-glucose
2-Deoxy-2-aminoglucose
2-amino-2-deoxy-D-glucopyranose
2-amino-2-deoxyglucose
2351-15-7
28905-10-4
2B4D44B2-D5AC-4DA4-9BE6-A4AE9574E4A6
3416-24-8
4-04-00-02017 (Beilstein Handbook Reference)
58-87-7
58267-75-7
6490-70-6
880765-44-6
90-77-7
911653-84-4
AC1L2D1C
AC1L96WB
AC1L9B8P
AC1Q4UBH
BRN 1724602
BSPBio_002086
C00329
C08349
CHEBI:28393
CHEBI:47977
CHEMBL234432
CID18897
CID439213
CID441477
CPD0-1193
Chitosamine
Cosamin
D-(+)-Glucosamine
 
D-Glucosamine
D-glucosamine
D04334
DB01296
DivK1c_000261
EINECS 222-311-2
GCS
Glucosamina
Glucosamina [INN-Spanish]
Glucosamine (USAN/INN)
Glucosamine [USAN:INN]
Glucosaminum
Glucosaminum [INN-Latin]
HMS500N03
HSDB 7469
IDI1_000261
InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6-/m1/s1
KBio1_000261
KBio2_001311
KBio2_003879
KBio2_006447
KBio3_001306
KBioGR_000970
KBioSS_001311
LS-71671
MolPort-002-507-091
MolPort-003-944-937
NCGC00164421-01
NCGC00178826-01
NINDS_000261
SPBio_000477
STK801823
Spectrum2_000519
Spectrum3_000443
Spectrum4_000565
Spectrum5_000756
Spectrum_000831
Viartril-S
beta-D-Glucosamine
bmse000247
chitosamine
glucosamine
nchembio.189-comp4
nchembio.2007.41-comp7
nchembio.412-comp5
partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1The Adult Hemorrhagic Moyamoya Surgery StudyActive, not recruitingNCT02319980Phase 3
2Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCompletedNCT01419275
3Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic StrokeRecruitingNCT02074111
4Characteristics and Outcomes of Childhood Moyamoya in the UKRecruitingNCT02434302
5Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing SurgeryRecruitingNCT02305407
6Subclavian Vein catheterization_Seldinger Vs Modified SeldingerRecruitingNCT02090010
7Stroke Imaging Package StudyRecruitingNCT02485275
8Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRIRecruitingNCT02914288
9Characterizing Hemodynamic Compensation in Patients With Intracranial StenosisRecruitingNCT02506907
10The Role of Cerebral Hemodynamics in Moyamoya DiseaseActive, not recruitingNCT00629915
11Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE SyndromeActive, not recruitingNCT01018082
12Sevoflurane and Hyperperfusion SyndromeNot yet recruitingNCT02510586

Search NIH Clinical Center for Moyamoya Disease


Cochrane evidence based reviews: moyamoya disease

Genetic Tests for Moyamoya Disease

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Genetic tests related to Moyamoya Disease:

id Genetic test Affiliating Genes
1 Moyamoya Disease 125
2 Moyamoya Disease25

Anatomical Context for Moyamoya Disease

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MalaCards organs/tissues related to Moyamoya Disease:

34
Brain, Testes, Endothelial, Smooth muscle, Thyroid, Bone, Pituitary

Animal Models for Moyamoya Disease or affiliated genes

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MGI Mouse Phenotypes related to Moyamoya Disease:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3ACTA2, FGF2, GUCY1A3, KDR, MMP9, RPTOR
2MP:00053888.1GUCY1A3, KDR, MMP9, RAI1, SHOC2, SIX3
3MP:00053917.6ACTA2, FGF2, GUCY1A3, KDR, MMP9, MTHFR
4MP:00053857.3ACTA2, FGF2, GUCY1A3, KDR, MMP9, RNF213
5MP:00053867.2FGF2, KDR, MMP9, RAI1, RNF213, RPTOR
6MP:00053786.8KDR, MMP9, MTHFR, RAI1, RNF213, RPTOR
7MP:00053906.7FGF2, KDR, MMP3, MMP9, MTHFR, RAI1
8MP:00036316.7FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
9MP:00053766.3FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
10MP:00107685.9CRABP1, FGF2, GUCY1A3, KDR, MMP9, MTHFR

Publications for Moyamoya Disease

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Articles related to Moyamoya Disease:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Dystonia an unusual presentation in pediatric moyamoya disease: Imaging findings of a case. (27606018)
2016
2
Moyamoya Disease: A Review of Clinical Research. (27549666)
2016
3
A Case of Homocystinuria Misdiagnosed as Moyamoya Disease: A Case Report. (27330833)
2016
4
Prolonged Mean Transit Time Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Predicts Cerebrovascular Reserve Impairment in Patients with Moyamoya Disease. (27088711)
2016
5
Clinical features and long-term outcomes of unilateral moyamoya disease. (27647029)
2016
6
Surgical Management of Giant Basilar Tip Aneurysm Associated with Moyamoya Disease: A Case Report and Literature Review. (25862110)
2015
7
Coronary heart disease in moyamoya disease: are they concomitant or coincidence? (25829816)
2015
8
Pretransplant management of basilar artery aneurysm and moyamoya disease in a child with Alagille syndrome. (26043700)
2015
9
Cognitive Dysfunction Survey of the Japanese Patients with Moyamoya Disease (COSMO-JAPAN Study): Study Protocol. (25739435)
2015
10
Moyamoya disease: A comparison of long term outcome of conservative and surgical treatment in India. (24183032)
2014
11
The collateral circulation in pediatric moyamoya disease. (25378261)
2014
12
Perfusion characteristics of moyamoya disease: an anatomically and clinically oriented analysis and comparison. (24193795)
2014
13
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
14
Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease. (23652271)
2013
15
Incidence, locations, and longitudinal course of silent microbleeds in moyamoya disease: a prospective T2*-weighted MRI study. (23223508)
2013
16
Role of Burr Hole Surgery in Patients with Moyamoya Disease. (23920308)
2013
17
Effect of delayed transit time on arterial spin labeling: correlation with dynamic susceptibility contrast perfusion magnetic resonance in moyamoya disease. (23764569)
2013
18
Moyamoya disease with exaggerated startle response: A rare co-occurrence. (24339629)
2013
19
Impaired dynamic cerebral autoregulation in Moyamoya disease. (23731503)
2013
20
Diagnosis of moyamoya disease on magnetic resonance imaging: are flow voids in the basal ganglia an essential criterion for definitive diagnosis? (22939199)
2013
21
High-resolution MR technique can distinguish moyamoya disease from atherosclerotic occlusion. (23420895)
2013
22
High resolution MRI difference between moyamoya disease and intracranial atherosclerosis. (23789981)
2013
23
Value of cerebral oxygen saturation monitoring during cardiopulmonary bypass in an adult patient with moyamoya disease. (22209176)
2013
24
Sex differences in clinical presentation and treatment outcomes in Moyamoya disease. (22718024)
2012
25
Clinical features, surgical treatment and long-term outcome in adult patients with Moyamoya disease in China. (23146868)
2012
26
Transient crossed cerebellar diaschisis due to cerebral hyperperfusion following surgical revascularization for moyamoya disease: case report. (22688075)
2012
27
Long-term follow-up results in 142 adult patients with moyamoya disease according to management modality. (22476796)
2012
28
Increased levels of circulating SDF-1I+ and CD34+ CXCR4+ cells in patients with moyamoya disease. (21435112)
2011
29
Analysis of ACTA2 in European Moyamoya disease patients. (20970362)
2011
30
Moyamoya disease: a review of histopathology, biochemistry, and genetics. (21631222)
2011
31
Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population. (20948207)
2010
32
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
33
Computed tomographic perfusion in assessing postoperative revascularization in moyamoya disease. (20860934)
2010
34
Thalamo-perforating artery aneurysm in Moyamoya disease - case report. (20515265)
2010
35
Combined spinal-epidural anesthesia for cesarean section in a patient with Moyamoya disease -A case report-. (21286427)
2010
36
Moyamoya disease. (20589474)
2010
37
Moyamoya disease: a clinical spectrum, literature review and case series from a tertiary care hospital in Pakistan. (19368734)
2009
38
Moyamoya disease: case report and literature review. (19861596)
2009
39
Surgical management of moyamoya disease: a review. (19335133)
2009
40
Laser Doppler flowmeter study on regional cerebral blood flow in early stage after standard superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease. (20079151)
2009
41
Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease. (19095988)
2009
42
Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease. (19147196)
2009
43
Effect of preoperative skull block on pediatric moyamoya disease. (18590393)
2008
44
Moyamoya disease associated with hemoglobin Fairfax and beta-thalassemia. (18206795)
2008
45
Case of moyamoya disease in a patient with advanced acquired immunodeficiency syndrome. (18035245)
2007
46
Stenosis of the proximal external carotid artery in an adult with moyamoya disease: moyamoya or atherosclerotic change? (17721051)
2007
47
Expression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease. (17290185)
2007
48
Intracerebral hemorrhage after prophylactic revascularization in a patient with adult moyamoya disease. (17719983)
2007
49
Basal meningoencephalocele, anomaly of optic disc and panhypopituitarism in association with moyamoya disease. (11070437)
2000
50
Angiogenic factors in moyamoya disease. (8969773)
1996

Variations for Moyamoya Disease

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Copy number variations for Moyamoya Disease from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
110690517178774742DeletionMoyamoya disease

Expression for genes affiliated with Moyamoya Disease

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Search GEO for disease gene expression data for Moyamoya Disease.

Pathways for genes affiliated with Moyamoya Disease

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Pathways related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.7MMP9, TGFB1
29.7MMP3, MMP9, TIMP2
39.7MMP3, MMP9, TIMP2
4
Show member pathways
9.7MMP3, MMP9, TIMP2
5
Show member pathways
9.6KDR, VEGFA
69.6ACTA2, FGF2, TGFB1
79.5FGF2, TGFB1, VEGFA
89.4MMP3, TGFB1, VEGFA
9
Show member pathways
9.4FGF2, KDR, VEGFA
109.4FGF2, KDR, VEGFA
119.4FGF2, KDR, VEGFA
129.3FGF2, KDR, TGFB1
139.2FGF2, MMP9, TGFB1, VEGFA
149.0ACTA2, KDR, TGFB1, VEGFA
159.0FGF2, KDR, TGFB1, VEGFA
169.0FGF2, KDR, TGFB1, VEGFA
17
Show member pathways
8.9FGF2, KDR, MMP9, TIMP2, VEGFA
188.7FGF2, KDR, MMP9, TGFB1, VEGFA
19
Show member pathways
8.5FGF2, KDR, MMP3, MMP9, TGFB1, TIMP2
20
Show member pathways
8.5FGF2, KDR, MMP3, MMP9, TGFB1, TIMP2
21
Show member pathways
8.3ACTA2, FGF2, GUCY1A3, KDR, TGFB1, TIMP2

GO Terms for genes affiliated with Moyamoya Disease

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Cellular components related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055788.9MMP3, MMP9, TGFB1, TIMP2, VEGFA
2extracellular spaceGO:00056158.5ACTA2, FGF2, MMP3, MMP9, TGFB1, TIMP2

Biological processes related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1hyaluronan catabolic processGO:003021410.3FGF2, TGFB1
2positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.2KDR, VEGFA
3positive regulation of positive chemotaxisGO:005092710.1KDR, VEGFA
4lens fiber cell differentiationGO:007030610.0SIX3, TGFB1
5positive regulation of blood vessel endothelial cell migrationGO:004353610.0FGF2, TGFB1, VEGFA
6cell migration involved in sprouting angiogenesisGO:000204210.0FGF2, KDR, VEGFA
7positive regulation of endothelial cell migrationGO:00105959.9FGF2, KDR, VEGFA
8positive regulation of cell divisionGO:00517819.9FGF2, TGFB1, VEGFA
9extracellular matrix disassemblyGO:00226179.8MMP3, MMP9, TIMP2
10negative regulation of blood vessel endothelial cell migrationGO:00435379.8FGF2, TGFB1
11positive regulation of epithelial cell proliferationGO:00506799.5FGF2, TGFB1, VEGFA
12positive regulation of endothelial cell proliferationGO:00019389.5FGF2, KDR, RPTOR, VEGFA
13positive regulation of MAP kinase activityGO:00434069.4FGF2, TGFB1, VEGFA
14angiogenesisGO:00015259.3FGF2, KDR, RNF213, VEGFA
15positive regulation of protein phosphorylationGO:00019348.9FGF2, KDR, MMP9, TGFB1, VEGFA

Sources for Moyamoya Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet