MYMY
MCID: MYM002
MIFTS: 61

Moyamoya Disease (MYMY) malady

Categories: Rare diseases, Cardiovascular diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Moyamoya Disease

Aliases & Descriptions for Moyamoya Disease:

Name: Moyamoya Disease 54 12 50 25 51 56 13 52 42 14 69
Moyamoya Disease 1 50 29 69
Spontaneous Occlusion of the Circle of Willis 50 25
Progressive Intracranial Arterial Occlusion 12 25
Moyamoya Disease 3 50 69
Moyamoya Disease 2 50 69
Moya-Moya Disease 25 29
Progressive Intracranial Occlusive Arteropathy 25
Cerebrovascular Moyamoya Disease 25
Moyamoya Disease, Secondary 50
Idiopathic Moyamoya Disease 56
Moyamoya Disease, Primary 50
Moyamoya Syndrome 50
Mymy 50

Characteristics:

Orphanet epidemiological data:

56
moyamoya disease
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial,X-linked recessive; Prevalence: 1-9/1000000 (France); Age of onset: All ages;

HPO:

32
moyamoya disease:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

OMIM 54 252350
Disease Ontology 12 DOID:13099
ICD10 33 I67.5
ICD9CM 35 437.5
MeSH 42 D009072
NCIt 47 C84895
SNOMED-CT 64 69116000 89142007
Orphanet 56 ORPHA2573
MESH via Orphanet 43 C536991 D009072
UMLS via Orphanet 70 C0026654 C2931384
ICD10 via Orphanet 34 I67.5
UMLS 69 C0026654

Summaries for Moyamoya Disease

NINDS : 51 Moyamoya disease is a rare, progressive cerebrovascular disorder caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name “moyamoya” means “puff of smoke” in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage.  Moyamoya disease was first described in Japan in the 1960s and it has since been found in individuals in the other countries around the world; its incidence is higher in Asian countries than in Europe or North America. The disease primarily affects children, but it can also occur in adults. In children, the first symptom of Moyamoya disease is often stroke, or recurrent transient ischemic attacks (TIA, commonly referred to as “mini-strokes”), frequently accompanied by muscular weakness or paralysis affecting one side of the body, or seizures.  Adults may also experience these symptoms that arise from blocked arteries, but more often experience a hemorrhagic stroke due to bleeding into the brain from the abnormal brain vessels.  Individuals with this disorder may have disturbed consciousness, problems with speaking and understanding speech, sensory and cognitive impairments, involuntary movements, and vision problems. About one in 10 individuals with Moyamoya disease has a close relative who is also affected; in these cases researchers think that Moyamoya disease is the result of inherited genetic abnormalities. Studies that look for the abnormal gene(s) may help reveal the biomechanisms that cause the disorder.

MalaCards based summary : Moyamoya Disease, also known as moyamoya disease 1, is related to myocardial infarction and moyamoya disease 2, and has symptoms including seizures, intellectual disability and ventriculomegaly. An important gene associated with Moyamoya Disease is RNF213 (Ring Finger Protein 213), and among its related pathways/superpathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. The drugs Xylometazoline and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and endothelial, and related phenotypes are homeostasis/metabolism and mortality/aging

Disease Ontology : 12 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.

Genetics Home Reference : 25 Moyamoya disease is a disorder of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. These vessels, which provide oxygen-rich blood to the brain, narrow over time. Narrowing of these vessels reduces blood flow in the brain. In an attempt to compensate, new networks of small, fragile blood vessels form. These networks, visualized by a particular test called an angiogram, resemble puffs of smoke, which is how the condition got its name: "moyamoya" is an expression meaning "something hazy like a puff of smoke" in Japanese.

NIH Rare Diseases : 50 moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. the name "moyamoya" means "puff of smoke" in japanese and describes the look of the tangled vessels that form to compensate for the blockage. this condition usually affects children, but can affect adults. affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (tias) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. researchers believe that moyamoya disease is an inherited condition because it tends to run in families.moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, sturge-weber syndrome, and tuberous sclerosis. last updated: 7/1/2014

OMIM : 54 Moyamoya is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion... (252350) more...

Wikipedia : 71 Moyamoya disease is a disease in which certain arteries in the brain are constricted. Blood flow is... more...

Related Diseases for Moyamoya Disease

Diseases in the Moyamoya Disease family:

Moyamoya Disease 3 Moyamoya Disease 5
Moyamoya Disease 2

Diseases related to Moyamoya Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.6 GUCY1A3 KDR MMP3 MMP9 MTHFR TGFB1
2 moyamoya disease 2 12.2
3 moyamoya disease 5 12.2
4 moyamoya disease 3 12.2
5 moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism 12.2
6 moyamoya 6 with achalasia 11.9
7 cerebritis 10.5
8 right atrium familial dilatation 10.3 MMP3 MMP9
9 central nervous system adult germ cell tumor 10.2 MMP3 MMP9 TIMP2
10 schwannomatosis 10.2 MMP3 MMP9 TIMP2
11 aneurysm 10.2
12 choroid plexus cancer 10.2 ACTA2 GUCY1A3 RNF213
13 adult neuronal ceroid lipofuscinosis 10.2 MMP9 TIMP2 VEGFA
14 maxillary neoplasm 10.2 MMP9 TIMP2 VEGFA
15 upper respiratory tract disease 10.2 FGF2 TGFB1 VEGFA
16 epidermolysis bullosa simplex, sutosomal recessive 2 10.2 FGF2 MMP9 VEGFA
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 FGF2 TGFB1 TIMP2 VEGFA
18 benign idiopathic neonatal seizures 10.1 FGF2 KDR VEGFA
19 kidney osteogenic sarcoma 10.1 KDR MMP9 VEGFA
20 neurilemmoma of the pleura 10.1 FGF2 KDR VEGFA
21 pituitary infarct 10.1 MMP3 MMP9 TGFB1 VEGFA
22 subdural empyema 10.1 FGF2 KDR VEGFA
23 oppositional defiant disorder 10.1 FGF2 KDR VEGFA
24 mixed ductal-endocrine carcinoma 10.1 MMP3 MMP9 TIMP2
25 metagonimiasis 10.1 FGF2 KDR VEGFA
26 multinodular goiter 10.1 KDR PDGFRB VEGFA
27 pseudoxanthoma elasticum 10.1
28 hypogonadotropic hypogonadism 20 with or without anosmia 10.1 FGF2 MMP9 TGFB1 VEGFA
29 ladd syndrome 10.1 FGF2 MMP9 TIMP2 VEGFA
30 autoimmune-related retinopathy and optic neuropathy 10.0 MMP3 MMP9 TGFB1 VEGFA
31 citrullinemia, type ii, neonatal-onset 10.0 FGF2 KDR VEGFA
32 mitral valve stenosis 10.0 FGF2 KDR PDGFRB VEGFA
33 endotheliitis 10.0
34 aminoaciduria 10.0 MMP9 MTHFR
35 grade iii astrocytoma 10.0 FGF2 KDR PDGFRB VEGFA
36 ischemia 10.0
37 hemolytic anemia 10.0 FGF2 KDR VEGFA
38 intracranial cysts 10.0 MTHFR VEGFA
39 testicular cancer 9.9 KDR MMP9 PDGFRB VEGFA
40 vernal conjunctivitis 9.9 KDR MTHFR VEGFA
41 ceroid lipofuscinosis, neuronal, 8 9.9 MMP3 MMP9 MTHFR VEGFA
42 arteriovenous malformation 9.9
43 neurofibromatosis 9.9
44 graves' disease 9.9
45 neurofibromatosis, type 1 9.9
46 choroiditis 9.9
47 down syndrome 9.9
48 pericarditis 9.9 FGF2 MMP9 MTHFR VEGFA
49 intracranial aneurysm 9.8
50 headache 9.8

Graphical network of the top 20 diseases related to Moyamoya Disease:



Diseases related to Moyamoya Disease

Symptoms & Phenotypes for Moyamoya Disease

Symptoms by clinical synopsis from OMIM:

252350

Clinical features from OMIM:

252350

Human phenotypes related to Moyamoya Disease:

56 32 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 56 32 Frequent (79-30%) HP:0001250
2 intellectual disability 56 32 Frequent (79-30%) HP:0001249
3 ventriculomegaly 56 32 Frequent (79-30%) HP:0002119
4 abnormality of the cerebral vasculature 56 32 Frequent (79-30%) HP:0100659
5 telangiectasia 56 32 Very frequent (99-80%) HP:0001009
6 inflammatory arteriopathy 32 HP:0005291

MGI Mouse Phenotypes related to Moyamoya Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 TIMP2 VEGFA FGF2 GUCY1A3 KDR MMP3
2 mortality/aging MP:0010768 10.18 CRABP1 FGF2 GUCY1A3 KDR MMP9 MTHFR
3 cardiovascular system MP:0005385 10.17 ACTA2 FGF2 GUCY1A3 KDR MMP9 PDGFRB
4 nervous system MP:0003631 10.03 FGF2 GUCY1A3 KDR MMP3 MMP9 MTHFR
5 muscle MP:0005369 9.97 ACTA2 FGF2 GUCY1A3 KDR MMP9 PDGFRB
6 respiratory system MP:0005388 9.76 RAI1 SHOC2 SIX3 TGFB1 VEGFA GUCY1A3
7 skeleton MP:0005390 9.7 MTHFR PDGFRB RAI1 RPTOR SIX3 TGFB1
8 vision/eye MP:0005391 9.32 ACTA2 FGF2 GUCY1A3 KDR MMP9 MTHFR

Drugs & Therapeutics for Moyamoya Disease

Drugs for Moyamoya Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Xylometazoline Approved Phase 3 526-36-3 5709
2 Epoetin alfa Phase 1, Phase 2 113427-24-0
3 Hematinics Phase 1, Phase 2
4 Anesthetics Phase 1, Phase 2
5
Sevoflurane Approved, Vet_approved 28523-86-6 5206
6
Glucosamine Approved, Nutraceutical 3416-24-8 439213
7 Glucuronyl glucosamine glycan sulfate
8 Hypoglycemic Agents
9 Hypolipidemic Agents
10 Fibrinolytic Agents
11 Anticoagulants
12 Lipid Regulating Agents
13 Antimetabolites
14 Xenon
15 Vasodilator Agents
16 Anticonvulsants
17 Antihypertensive Agents
18 Anesthetics, General
19 Anesthetics, Inhalation
20 Platelet Aggregation Inhibitors
21 Central Nervous System Depressants

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 The Adult Hemorrhagic Moyamoya Surgery Study Active, not recruiting NCT02319980 Phase 3
2 Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya Completed NCT03162588 Phase 1, Phase 2
3 The Role of Cerebral Hemodynamics in Moyamoya Disease Unknown status NCT00629915
4 Characteristics and Outcomes of Childhood Moyamoya in the UK Unknown status NCT02434302
5 Subclavian Vein catheterization_Seldinger Vs Modified Seldinger Unknown status NCT02090010
6 Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients Completed NCT01419275
7 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
8 Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke Recruiting NCT02074111
9 Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease Recruiting NCT02982135
10 Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery Recruiting NCT02305407
11 Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome Recruiting NCT03072914
12 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Recruiting NCT02914288
13 Stroke Imaging Package Study Recruiting NCT02485275
14 Characterizing Hemodynamic Compensation in Patients With Intracranial Stenosis Active, not recruiting NCT02506907
15 EEG Monitoring in Children With Moyamoya Disease Not yet recruiting NCT03173014
16 Sevoflurane and Hyperperfusion Syndrome Not yet recruiting NCT02510586

Search NIH Clinical Center for Moyamoya Disease

Cochrane evidence based reviews: moyamoya disease

Genetic Tests for Moyamoya Disease

Genetic tests related to Moyamoya Disease:

id Genetic test Affiliating Genes
1 Moyamoya Disease 1 29
2 Moyamoya Disease 29

Anatomical Context for Moyamoya Disease

MalaCards organs/tissues related to Moyamoya Disease:

39
Brain, Testes, Endothelial, Smooth Muscle, Bone, Thyroid, Pituitary

Publications for Moyamoya Disease

Articles related to Moyamoya Disease:

(show top 50) (show all 707)
id Title Authors Year
1
Indocyanine green visualization of middle meningeal artery before craniotomy during surgical revascularization for moyamoya disease. ( 28050720 )
2017
2
Unilateral moyamoya disease with co-existing arteriovenous malformation. ( 28084278 )
2017
3
Impact of aberrant cerebral perfusion on resting-state functional MRI: A preliminary investigation of Moyamoya disease. ( 28441445 )
2017
4
Exome Sequencing Identified CCER2 as a Novel Candidate Gene for Moyamoya Disease. ( 27717682 )
2017
5
Complementary relation between direct and indirect bypass in progress of collateral circulation in moyamoya disease. ( 28478244 )
2017
6
Cortical Venous Redness Represents Tissue Circulation Status in Patients With Moyamoya Disease. ( 28446622 )
2017
7
Neurocognitive Performance After Cerebral Revascularization in Adult Moyamoya Disease. ( 28487332 )
2017
8
Etiology and pathogenesis of Moyamoya Disease: An update on disease prevalence. ( 28381201 )
2017
9
Proposal for a Prospective Registry for Moyamoya Disease in Japan. ( 28070115 )
2017
10
Long Term Outcome After Conservative Treatment and Direct Bypass Surgery of Moyamoya Disease at Late Suzuki Stage. ( 28366750 )
2017
11
Persistent Hypotension and Cerebral Swelling Resulting From Mesenteric Traction Syndrome After Omental-to-Pial Pedicle Flap Transfer in a Young Woman With Refractory Moyamoya Disease: A Case Report. ( 28520567 )
2017
12
Safety of Extracranial-Intracranial Arterial Bypass in the Treatment of Moyamoya Disease. ( 28060096 )
2017
13
Moyamoya Disease as a Cause of Stroke in a Child with Tetralogy of Fallot. ( 28479818 )
2017
14
Awake Surgery for Brain Vascular Malformations and Moyamoya Disease. ( 28377246 )
2017
15
Natural History and Risk Factor of Recurrent Hemorrhage in Hemorrhagic Adult Moyamoya Disease. ( 28402467 )
2017
16
Angiographic features of hemorrhagic moyamoya disease with high recurrence risk: a supplementary analysis of the Japan Adult Moyamoya Trial. ( 28409736 )
2017
17
Moyamoya disease presenting as bilateral acute subdural hematomas without deficits. ( 28484538 )
2017
18
Correlation between reduction in microvascular transit time after superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease and the development of postoperative hyperperfusion syndrome. ( 28498060 )
2017
19
Cerebral blood flow, transit time, and apparent diffusion coefficient in moyamoya disease before and after acetazolamide. ( 27913820 )
2017
20
Meta-analysis of the surgical outcomes of symptomatic moyamoya disease in adults. ( 28474994 )
2017
21
Infarct Pattern and Collateral Status in Adult Moyamoya Disease: A Multimodal Magnetic Resonance Imaging Study. ( 27909201 )
2017
22
Moyamoya disease with occlusion of bilateral vertebral arteries and the basilar artery fed by the collateral vessels of vertebral arteries: A rare case report. ( 28385458 )
2017
23
Patient With Severe Moyamoya Disease Who Presents With Acute Cortical Blindness. ( 28411258 )
2017
24
The association of the RNF213 p.R4810K polymorphism with quasi-moyamoya disease and a review of the pertinent literature. ( 28063898 )
2017
25
Ischemic Stroke in Young Adults with Moyamoya Disease: Prognostic Factors for Stroke Recurrence and Functional Outcome after Revascularization. ( 28408257 )
2017
26
Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. ( 28072843 )
2017
27
Reply to: Moyamoya disease and systemic sclerosis (MoSys syndrome): a combination of two rare entities: comment to the authors. ( 28516875 )
2017
28
Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia. ( 28497183 )
2017
29
RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease. ( 28506590 )
2017
30
Association between the rs112735431 polymorphism of the RNF213 gene and moyamoya disease: A case-control study and meta-analysis. ( 27515544 )
2016
31
Five-year experience of 101 adult patients with moyamoya disease at a single institution in Eastern China. ( 27506781 )
2016
32
Neuropsychiatric manifestations in a child with moyamoya disease. ( 27114683 )
2016
33
Edaravone Reduces Hyperperfusion-Related Neurological Deficits in Adult Moyamoya Disease: Historical Control Study. ( 27174526 )
2016
34
Long-term follow-up of pediatric moyamoya disease treated by combined direct-indirect revascularization surgery: single institute experience with surgical and perioperative management. ( 27180559 )
2016
35
Perioperative complications and long-term outcomes after bypasses in adults with moyamoya disease: a systematic review and meta-analysis. ( 27150649 )
2016
36
Retinal Arterial Tortuosity in Moyamoya Disease. ( 26605691 )
2016
37
Impact of abnormal cerebrovascular reactivity on BOLD fMRI: a preliminary investigation of moyamoya disease. ( 27572110 )
2016
38
Establishment of induced pluripotent stem cell (iPSC) line from 55-year old male patient with hemorrhagic Moyamoya disease. ( 27934594 )
2016
39
RNF213 as the major susceptibility gene for Chinese patients with moyamoya disease and its clinical relevance. ( 27128593 )
2016
40
Moyamoya Disease. ( 27960175 )
2016
41
Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report. ( 27882137 )
2016
42
Grading of moyamoya disease allows stratification for postoperative ischemia in bilateral revascularization surgery. ( 27573349 )
2016
43
Subcortical low-intensity lesions on fluid-attenuated inversion recovery images after revascularization surgery for moyamoya disease. ( 27888077 )
2016
44
Moyamoya disease and systemic sclerosis (MoSys syndrome): a combination of two rare entities. ( 27606722 )
2016
45
Changes to the geometry and fluid mechanics of the carotid siphon in the pediatric Moyamoya disease. ( 27166074 )
2016
46
Laparoscopic cholecystectomy in an adult moyamoya disease case. ( 27871534 )
2016
47
Neuromodulatory role of revascularization surgery in moyamoya disease. ( 27150656 )
2016
48
Comparison of 7T and 3T MRI in patients with moyamoya disease. ( 27899331 )
2016
49
The association between the ring finger protein 213 (RNF213) polymorphisms and moyamoya disease susceptibility: a meta-analysis based on case-control studies. ( 26847828 )
2016
50
Determinants of Basal Collaterals in Moyamoya Disease: Clinical and Genetic Factors. ( 27046023 )
2016

Variations for Moyamoya Disease

Copy number variations for Moyamoya Disease from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 106905 17 1 78774742 Deletion Moyamoya disease

Expression for Moyamoya Disease

Search GEO for disease gene expression data for Moyamoya Disease.

Pathways for Moyamoya Disease

Pathways related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 ACTA2 FGF2 KDR MMP3 MMP9 PDGFRB
2
Show member pathways
13.13 ACTA2 FGF2 GUCY1A3 KDR PDGFRB TGFB1
3
Show member pathways
12.98 ACTA2 FGF2 KDR PDGFRB TGFB1 TIMP2
4
Show member pathways
12.64 FGF2 KDR PDGFRB SHOC2 VEGFA
5
Show member pathways
12.59 FGF2 KDR MMP3 MMP9 TGFB1 TIMP2
6 12.57 FGF2 MMP9 PDGFRB TGFB1 VEGFA
7 12.47 FGF2 KDR PDGFRB RPTOR VEGFA
8
Show member pathways
12.3 ACTA2 FGF2 KDR VEGFA
9 12.11 FGF2 KDR MMP9 TGFB1 VEGFA
10
Show member pathways
11.81 MMP3 MMP9 TIMP2
11 11.79 ACTA2 FGF2 TGFB1
12 11.78 FGF2 KDR PDGFRB TGFB1 VEGFA
13 11.75 MMP3 TGFB1 VEGFA
14 11.61 FGF2 MMP3 MMP9 TGFB1 VEGFA
15 11.6 ACTA2 KDR TGFB1 VEGFA
16 11.57 FGF2 MMP9 TGFB1
17
Show member pathways
11.57 MMP3 MMP9 VEGFA
18 11.55 MMP3 MMP9 TIMP2
19 11.48 FGF2 MMP9 TGFB1 VEGFA
20 11.46 FGF2 KDR TGFB1
21 11.4 FGF2 TGFB1 VEGFA
22 11.36 FGF2 KDR VEGFA
23
Show member pathways
11.31 KDR PDGFRB VEGFA
24 11.31 FGF2 KDR TGFB1 VEGFA
25 11.26 MMP3 MMP9 TIMP2
26 11.11 FGF2 KDR MMP3 MMP9 PDGFRB TGFB1
27 11.02 FGF2 TGFB1 VEGFA
28
Show member pathways
10.85 KDR VEGFA
29 10.73 FGF2 KDR MMP9 TIMP2 VEGFA

GO Terms for Moyamoya Disease

Cellular components related to Moyamoya Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.02 MMP3 MMP9 TGFB1 TIMP2 VEGFA

Biological processes related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 FGF2 KDR PDGFRB TGFB1 VEGFA
2 angiogenesis GO:0001525 9.85 FGF2 KDR RNF213 VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 FGF2 KDR PDGFRB TGFB1
4 wound healing GO:0042060 9.77 FGF2 PDGFRB TGFB1
5 positive regulation of protein phosphorylation GO:0001934 9.76 KDR MMP9 TGFB1 VEGFA
6 extracellular matrix disassembly GO:0022617 9.73 MMP3 MMP9 TIMP2
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.71 RPTOR TGFB1 VEGFA
8 vasculogenesis GO:0001570 9.69 KDR TGFB1 VEGFA
9 positive regulation of cell division GO:0051781 9.65 FGF2 TGFB1 VEGFA
10 hyaluronan catabolic process GO:0030214 9.61 FGF2 TGFB1
11 negative regulation of blood vessel endothelial cell migration GO:0043537 9.61 FGF2 TGFB1
12 lens fiber cell differentiation GO:0070306 9.59 SIX3 TGFB1
13 positive regulation of chemotaxis GO:0050921 9.58 PDGFRB TGFB1
14 positive regulation of positive chemotaxis GO:0050927 9.57 KDR VEGFA
15 positive regulation of endothelial cell proliferation GO:0001938 9.56 FGF2 KDR RPTOR VEGFA
16 positive regulation of cell migration GO:0030335 9.55 KDR MMP9 PDGFRB TGFB1 VEGFA
17 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.54 FGF2 PDGFRB TGFB1
18 positive regulation of phospholipase C activity GO:0010863 9.52 FGF2 PDGFRB
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.5 FGF2 TGFB1 VEGFA
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.43 KDR VEGFA
21 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.4 PDGFRB VEGFA
22 cell migration involved in sprouting angiogenesis GO:0002042 9.13 FGF2 KDR VEGFA
23 positive regulation of MAP kinase activity GO:0043406 8.92 FGF2 PDGFRB TGFB1 VEGFA

Molecular functions related to Moyamoya Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 8.62 PDGFRB VEGFA

Sources for Moyamoya Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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