MCID: MYM002
MIFTS: 60

Moyamoya Disease malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Moyamoya Disease

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Moyamoya Disease:

Name: Moyamoya Disease 52 11 48 25 49 54 12 50 39 13 68
Moyamoya Disease 1 48 27 68
Spontaneous Occlusion of the Circle of Willis 48 25
Progressive Intracranial Arterial Occlusion 11 25
Moyamoya Disease 3 48 68
Moyamoya Disease 2 48 68
Moya-Moya Disease 25 27
 
Progressive Intracranial Occlusive Arteropathy 25
Cerebrovascular Moyamoya Disease 25
Moyamoya Disease, Secondary 48
Moyamoya Disease, Primary 48
Moyamoya Syndrome 48
Mymy 48

Characteristics:

Orphanet epidemiological data:

54
moyamoya disease:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial,X-linked recessive; Prevalence: 1-9/1000000 (France); Age of onset: All ages

HPO:

64
moyamoya disease:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 252350
Disease Ontology11 DOID:13099
ICD1030 I67.5
ICD9CM32 437.5
MeSH39 D009072
SNOMED-CT62 69116000, 89142007
NCIt45 C84895
Orphanet54 ORPHA2573
MESH via Orphanet40 C536991, D009072
UMLS via Orphanet69 C0026654, C2931384
ICD10 via Orphanet31 I67.5

Summaries for Moyamoya Disease

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OMIM:52 Moyamoya is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion... (252350) more...

MalaCards based summary: Moyamoya Disease, also known as moyamoya disease 1, is related to myocardial infarction and moyamoya disease 5, and has symptoms including seizures, ventriculomegaly and cognitive impairment. An important gene associated with Moyamoya Disease is RNF213 (Ring Finger Protein 213), and among its related pathways are VEGF binds to VEGFR leading to receptor dimerization and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, testes and endothelial, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:11 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.

Genetics Home Reference:25 Moyamoya disease is a disorder of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. These vessels, which provide oxygen-rich blood to the brain, narrow over time. Narrowing of these vessels reduces blood flow in the brain. In an attempt to compensate, new networks of small, fragile blood vessels form. These networks, visualized by a particular test called an angiogram, resemble puffs of smoke, which is how the condition got its name: "moyamoya" is an expression meaning "something hazy like a puff of smoke" in Japanese.

NIH Rare Diseases:48 Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name moyamoya means puff of smoke in Japanese and describes the look of the tangled vessels that form to compensate for the blockage. This condition usually affects children, but can affect adults. Affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (TIAs) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. Affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. Researchers believe that Moyamoya disease is an inherited condition because it tends to run in families.Moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, Sturge-Weber syndrome, and tuberous sclerosis. Last updated: 7/1/2014

NINDS:49 Moyamoya disease is a rare, progressive cerebrovascular disorder caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name ?moyamoya? means ?puff of smoke? in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage.

Wikipedia:71 Moyamoya disease is a disease in which certain arteries in the brain are constricted. Blood flow is... more...

Related Diseases for Moyamoya Disease

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Diseases in the Moyamoya Disease family:

Moyamoya Disease 3 Moyamoya Disease 5
Moyamoya Disease 2

Diseases related to Moyamoya Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction28.4GUCY1A3, MMP3, MMP9, MTHFR, TGFB1, VEGFA
2moyamoya disease 512.2
3moyamoya disease 212.2
4moyamoya disease 312.2
5moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism12.2
6moyamoya 6 with achalasia11.9
7rhizomelic dysplasia, scoliosis, and retinitis pigmentosa10.6MMP3, MMP9
8acute salpingo-oophoritis10.5ACTA2, GUCY1A3, RNF213
9cerebritis10.5
10pathological gambling10.5MMP3, MMP9
11thrombocytosis10.4FGF2, TGFB1
12diamond-blackfan anemia10.4MMP9, TGFB1
13pericardial mesothelioma10.4FGF2, TGFB1
14colorectal adenoma10.4FGF2, VEGFA
15pineal region yolk sac tumor10.4MMP3, MMP9, TIMP2
16schwannomatosis10.4MMP3, MMP9, TIMP2
17granulomatous orchitis10.4FGF2, MMP3, TGFB1
18vitreous abscess10.4FGF2, TGFB1, VEGFA
19intestinal benign neoplasm10.4MMP9, TIMP2, VEGFA
20adenosine monophosphate deaminase 1 deficiency10.4MMP9, TIMP2, VEGFA
21chorioretinitis10.4MMP3, MMP9, VEGFA
22exudative vitreoretinopathy 110.4FGF2, TGFB1, TIMP2
23vertebral artery occlusion10.3MMP3, MMP9, VEGFA
24impetigo herpetiformis10.3MMP3, MMP9, TIMP2
25emphysematous cholecystitis10.3MMP9, VEGFA
26dental pulp disease10.3FGF2, TGFB1, VEGFA
27silicosiderosis10.3KDR, VEGFA
28neuropathy, hereditary sensory and autonomic, type vi10.3FGF2, MMP9, VEGFA
29malignant giant cell tumor10.3MMP3, MMP9, VEGFA
30keratopathy10.3TGFB1, TIMP2
31dysostosis10.2MMP9, TGFB1, VEGFA
32gastric small cell carcinoma10.2FGF2, KDR, VEGFA
33epidural abscess10.2FGF2, KDR, VEGFA
34plague10.2MMP3, MMP9
35aneurysm10.2
36hydromyelia10.2MTHFR, VEGFA
37naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.2FGF2, TGFB1, TIMP2, VEGFA
38lung carcinoma in situ10.2FGF2, KDR, VEGFA
39gallbladder papillomatosis10.2MMP9, TGFB1, VEGFA
40renal fibrosis10.2FGF2, KDR, VEGFA
41bladder urachal carcinoma10.2KDR, MMP9, VEGFA
42ameloblastic carcinoma10.2MMP9, MTHFR
43villous adenoma10.2MMP9, TGFB1, VEGFA
44hematopoietic stem cell transplantation10.2FGF2, KDR, VEGFA
45lobular neoplasia10.1MMP9, TGFB1, TIMP2, VEGFA
46hemopneumothorax10.1MMP9, VEGFA
47gemistocytic astrocytoma10.1FGF2, MMP9, TGFB1, VEGFA
48autoimmune hepatitis10.1MMP3, MMP9, TGFB1, VEGFA
49citrullinemia, adult-onset type ii10.1FGF2, KDR, VEGFA
50endotheliitis10.0

Graphical network of the top 20 diseases related to Moyamoya Disease:



Diseases related to moyamoya disease

Symptoms & Phenotypes for Moyamoya Disease

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Symptoms by clinical synopsis from OMIM:

252350

Clinical features from OMIM:

252350

Human phenotypes related to Moyamoya Disease:

 64 54 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures64 54 typical (50%) Frequent (79-30%) HP:0001250
2 ventriculomegaly64 54 typical (50%) Frequent (79-30%) HP:0002119
3 cognitive impairment64 typical (50%) HP:0100543
4 abnormality of the cerebral vasculature64 54 typical (50%) Frequent (79-30%) HP:0100659
5 telangiectasia64 54 Very frequent (99-80%) HP:0001009
6 inflammatory arteriopathy64 HP:0005291
7 intellectual disability54 Frequent (79-30%)

MGI Mouse Phenotypes related to Moyamoya Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7GUCY1A3, KDR, MMP9, RAI1, SHOC2, SIX3
2MP:00053698.6ACTA2, FGF2, GUCY1A3, KDR, MMP9, PDGFRB
3MP:00053858.4ACTA2, FGF2, GUCY1A3, KDR, MMP9, PDGFRB
4MP:00053978.4FGF2, GUCY1A3, KDR, MMP3, MMP9, PDGFRB
5MP:00053787.6KDR, MMP9, MTHFR, PDGFRB, RAI1, RNF213
6MP:00053907.5FGF2, KDR, MMP3, MMP9, MTHFR, PDGFRB
7MP:00036317.4FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
8MP:00053917.2ACTA2, FGF2, GUCY1A3, KDR, MMP9, MTHFR
9MP:00053767.2FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
10MP:00107686.5CRABP1, FGF2, GUCY1A3, KDR, MMP9, MTHFR

Drugs & Therapeutics for Moyamoya Disease

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Drugs for Moyamoya Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
XylometazolineapprovedPhase 372526-36-35709
Synonyms:
 
Balminil
Xylomethazoline
2
Sevofluraneapproved, vet_approved47928523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
3
Glucosamineapproved, Nutraceutical1823416-24-8439213
Synonyms:
(+)-2-amino-2-deoxy-D-glucopyranose
(2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(2S,5R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
14257-69-3
2-Amino-2-deoxy-D-Glucose
2-Amino-2-deoxy-D-glucopyranose
2-Amino-2-deoxy-D-glucose
2-Amino-2-deoxy-beta-D-glucopyranose
2-Amino-2-deoxyglucose
2-Aminoglucose
2-Deoxy-2-amino-D-glucose
2-Deoxy-2-aminoglucose
2-amino-2-deoxy-D-glucopyranose
2-amino-2-deoxyglucose
2351-15-7
28905-10-4
2B4D44B2-D5AC-4DA4-9BE6-A4AE9574E4A6
3416-24-8
4-04-00-02017 (Beilstein Handbook Reference)
58-87-7
58267-75-7
6490-70-6
880765-44-6
90-77-7
911653-84-4
AC1L2D1C
AC1L96WB
AC1L9B8P
AC1Q4UBH
BRN 1724602
BSPBio_002086
C00329
C08349
CHEBI:28393
CHEBI:47977
CHEMBL234432
CID18897
CID439213
CID441477
CPD0-1193
Chitosamine
Cosamin
D-(+)-Glucosamine
 
D-Glucosamine
D-glucosamine
D04334
DB01296
DivK1c_000261
EINECS 222-311-2
GCS
Glucosamina
Glucosamina [INN-Spanish]
Glucosamine (USAN/INN)
Glucosamine [USAN:INN]
Glucosaminum
Glucosaminum [INN-Latin]
HMS500N03
HSDB 7469
IDI1_000261
InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6-/m1/s1
KBio1_000261
KBio2_001311
KBio2_003879
KBio2_006447
KBio3_001306
KBioGR_000970
KBioSS_001311
LS-71671
MolPort-002-507-091
MolPort-003-944-937
NCGC00164421-01
NCGC00178826-01
NINDS_000261
SPBio_000477
STK801823
Spectrum2_000519
Spectrum3_000443
Spectrum4_000565
Spectrum5_000756
Spectrum_000831
Viartril-S
beta-D-Glucosamine
bmse000247
chitosamine
glucosamine
nchembio.189-comp4
nchembio.2007.41-comp7
nchembio.412-comp5
partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
4Lipid Regulating Agents2702
5Anticoagulants2516
6Hypolipidemic Agents2721
7Hypoglycemic Agents5733
8Antimetabolites11774
9Glucuronyl glucosamine glycan sulfate132
10Fibrinolytic Agents2317
11Xenon66
12Antihypertensive Agents4095
13Anticonvulsants2620
14Vasodilator Agents3438
15Platelet Aggregation Inhibitors2419
16Central Nervous System Depressants12806
17Anesthetics, General2787
18Anesthetics9001
19Anesthetics, Inhalation649

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1The Adult Hemorrhagic Moyamoya Surgery StudyActive, not recruitingNCT02319980Phase 3
2Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic StrokeUnknown statusNCT02074111
3Subclavian Vein catheterization_Seldinger Vs Modified SeldingerUnknown statusNCT02090010
4Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCompletedNCT01419275
5Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya DiseaseRecruitingNCT02982135
6Characteristics and Outcomes of Childhood Moyamoya in the UKRecruitingNCT02434302
7Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing SurgeryRecruitingNCT02305407
8Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRIRecruitingNCT02914288
9Characterizing Hemodynamic Compensation in Patients With Intracranial StenosisRecruitingNCT02506907
10Stroke Imaging Package StudyRecruitingNCT02485275
11The Role of Cerebral Hemodynamics in Moyamoya DiseaseActive, not recruitingNCT00629915
12Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE SyndromeActive, not recruitingNCT01018082
13Sevoflurane and Hyperperfusion SyndromeNot yet recruitingNCT02510586

Search NIH Clinical Center for Moyamoya Disease


Cochrane evidence based reviews: moyamoya disease

Genetic Tests for Moyamoya Disease

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Genetic tests related to Moyamoya Disease:

id Genetic test Affiliating Genes
1 Moyamoya Disease 127
2 Moyamoya Disease27

Anatomical Context for Moyamoya Disease

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MalaCards organs/tissues related to Moyamoya Disease:

36
Brain, Testes, Endothelial, Smooth muscle, Thyroid, Bone, Pituitary

Publications for Moyamoya Disease

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Articles related to Moyamoya Disease:

(show top 50)    (show all 682)
idTitleAuthorsYear
1
Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease. (28072843)
2017
2
Proposal for a Prospective Registry for Moyamoya Disease in Japan. (28070115)
2017
3
Unilateral moyamoya disease with co-existing arteriovenous malformation. (28084278)
2017
4
Indocyanine green visualization of middle meningeal artery before craniotomy during surgical revascularization for moyamoya disease. (28050720)
2017
5
The association of the RNF213 p.R4810K polymorphism with quasi-moyamoya disease and a review of the pertinent literature. (28063898)
2017
6
Safety of Extracranial-Intracranial Arterial Bypass in the Treatment of Moyamoya Disease. (28060096)
2017
7
Infarct Pattern and Collateral Status in Adult Moyamoya Disease: A Multimodal Magnetic Resonance Imaging Study. (27909201)
2017
8
Cerebral blood flow, transit time, and apparent diffusion coefficient in moyamoya disease before and after acetazolamide. (27913820)
2017
9
Dystonia an unusual presentation in pediatric moyamoya disease: Imaging findings of a case. (27606018)
2016
10
Moyamoya Disease: A Review of Clinical Research. (27549666)
2016
11
A Case of Homocystinuria Misdiagnosed as Moyamoya Disease: A Case Report. (27330833)
2016
12
Prolonged Mean Transit Time Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Predicts Cerebrovascular Reserve Impairment in Patients with Moyamoya Disease. (27088711)
2016
13
Clinical features and long-term outcomes of unilateral moyamoya disease. (27647029)
2016
14
Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease. (27207169)
2016
15
Retinal Arterial Tortuosity in Moyamoya Disease. (26605691)
2016
16
Histopathological Characteristics of Distal Middle Cerebral Artery in Adult and Pediatric Patients with Moyamoya Disease. (27087193)
2016
17
Grading of moyamoya disease allows stratification for postoperative ischemia in bilateral revascularization surgery. (27573349)
2016
18
Topographic changes in cerebral blood flow and reduced white matter integrity in the first 2 weeks following revascularization surgery in adult moyamoya disease. (27588593)
2016
19
Neuromodulatory role of revascularization surgery in moyamoya disease. (27150656)
2016
20
Establishment of induced pluripotent stem cell (iPSC) line from 55-year old male patient with hemorrhagic Moyamoya disease. (27934594)
2016
21
Long-term follow-up of pediatric moyamoya disease treated by combined direct-indirect revascularization surgery: single institute experience with surgical and perioperative management. (27180559)
2016
22
Changes to the geometry and fluid mechanics of the carotid siphon in the pediatric Moyamoya disease. (27166074)
2016
23
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. (27068774)
2016
24
Determinants of Basal Collaterals in Moyamoya Disease: Clinical and Genetic Factors. (27046023)
2016
25
Ultrasonographic Changes after Indirect Revascularization Surgery in Pediatric Patients with Moyamoya Disease. (27639432)
2016
26
Posterior Circulation Moyamoya Disease Versus Primitive Vertebral-Basilar Artery System Moyamoya Disease: A New Classification of Moyamoya Disease From the Perspective of Embryology. (27593720)
2016
27
Moyamoya Disease in a Patient with VACTERL Association. (26844876)
2016
28
Is Quasi-moyamoya Disease a Uniform Disease Entity? A Three-Dimensional Constructive Interference in Steady State Imaging Study. (27038981)
2016
29
Ruptured Aneurysms of Collateral Vessels in Adult Onset Moyamoya Disease with Hemorrhagic Presentation. (27966197)
2016
30
Moyamoya disease. (28011851)
2016
31
Characterization of Clinical and Radiological Features of Quasi-Moyamoya Disease among European Caucasians Including Surgical Treatment and Outcome. (27578358)
2016
32
Temporary Steno-occlusive Change in the Donor Artery During Mouth Opening (Big Bite Ischemic Phenomenon) After Superficial Temporal Artery to Middle Cerebral Artery Bypass in Adult Patients with Moyamoya Disease and Atherosclerosis. (27637638)
2016
33
Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan. (27089195)
2016
34
Postoperative executive function in adult moyamoya disease: a preliminary study of its functional anatomy and behavioral correlates. (27058195)
2016
35
Nonatheroscleotic Isolated Middle Cerebral Artery Disease May Be Early Manifestation of Moyamoya Disease. (27507861)
2016
36
Moyamoya disease and systemic sclerosis (MoSys syndrome): a combination of two rare entities. (27606722)
2016
37
Histopathological features of middle cerebral artery and superficial temporal artery from patients with moyamoya disease and enlightenments on clinical treatment. (27924520)
2016
38
Hemodynamic contribution of transdural collateral flow in adult patients with moyamoya disease. (27590482)
2016
39
RNF213 as the major susceptibility gene for Chinese patients with moyamoya disease and its clinical relevance. (27128593)
2016
40
Moyamoya disease: impact on the performance of oral and written language. (27849243)
2016
41
Cellular Functions and Gene and Protein Expression Profiles in Endothelial Cells Derived from Moyamoya Disease-Specific iPS Cells. (27662211)
2016
42
Moyamoya disease and artery tortuosity as rare phenotypes in a patient with an elastin mutation. (27080061)
2016
43
Comparison of 7T and 3T MRI in patients with moyamoya disease. (27899331)
2016
44
More precise imaging analysis and diagnosis of moyamoya disease and moyamoya syndrome using high-resolution magnetic resonance imaging. (27576769)
2016
45
Carotid Endarterectomy in Moyamoya disease: a case report. (27177701)
2016
46
Significance of cyclooxygenase-2 elevation in middle cerebral artery for patients with hemorrhagic moyamoya disease. (27072959)
2016
47
Universal Bypass for Treatment of Symptomatic Moyamoya Disease or Moyamoya Syndrome. Analysis of a Personal Case Series on Behalf of the Italian Moyamoya Association. (27637639)
2016
48
Familial moyamoya disease in two Turkish siblings with same polymorphism in RNF213 gene but different clinical features. (26277359)
2016
49
Five-year experience of 101 adult patients with moyamoya disease at a single institution in Eastern China. (27506781)
2016
50
Intraoperative dexmedetomidine and postoperative cerebral hyperperfusion syndrome in patients who underwent superficial temporal artery-middle cerebral artery anastomosis for moyamoya disease: A retrospective observational study. (28033272)
2016

Variations for Moyamoya Disease

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Copy number variations for Moyamoya Disease from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
110690517178774742DeletionMoyamoya disease

Expression for genes affiliated with Moyamoya Disease

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Search GEO for disease gene expression data for Moyamoya Disease.

Pathways for genes affiliated with Moyamoya Disease

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Pathways related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9KDR, VEGFA
29.8ACTA2, FGF2, TGFB1
39.7FGF2, KDR, VEGFA
49.7FGF2, TGFB1, VEGFA
59.6FGF2, KDR, TGFB1
69.6MMP3, TGFB1, VEGFA
79.6MMP3, MMP9, TIMP2
89.6MMP3, MMP9, TIMP2
9
Show member pathways
9.6MMP3, MMP9, TIMP2
109.6KDR, PDGFRB, VEGFA
119.4ACTA2, KDR, TGFB1, VEGFA
129.4FGF2, KDR, TGFB1, VEGFA
139.4FGF2, KDR, PDGFRB, VEGFA
149.3FGF2, MMP9, TGFB1, VEGFA
15
Show member pathways
9.1FGF2, KDR, PDGFRB, SHOC2, VEGFA
16
Show member pathways
9.1FGF2, KDR, MMP9, TIMP2, VEGFA
179.0FGF2, KDR, PDGFRB, TGFB1, VEGFA
189.0FGF2, KDR, PDGFRB, RPTOR, VEGFA
199.0FGF2, KDR, MMP9, TGFB1, VEGFA
208.9FGF2, MMP9, PDGFRB, TGFB1, VEGFA
21
Show member pathways
8.9ACTA2, FGF2, KDR, PDGFRB, TGFB1, TIMP2
22
Show member pathways
8.7FGF2, KDR, MMP3, MMP9, TGFB1, TIMP2
23
Show member pathways
8.4FGF2, KDR, MMP3, MMP9, PDGFRB, TGFB1
24
Show member pathways
8.4ACTA2, FGF2, GUCY1A3, KDR, PDGFRB, TGFB1
25
Show member pathways
7.9ACTA2, FGF2, KDR, MMP3, MMP9, PDGFRB

GO Terms for genes affiliated with Moyamoya Disease

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Cellular components related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.2ACTA2, FGF2, MMP3, MMP9, TGFB1, TIMP2
2proteinaceous extracellular matrixGO:00055789.0MMP3, MMP9, TGFB1, TIMP2, VEGFA

Biological processes related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1hyaluronan catabolic processGO:003021410.7FGF2, TGFB1
2negative regulation of blood vessel endothelial cell migrationGO:004353710.7FGF2, TGFB1
3positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.6KDR, VEGFA
4positive regulation of phospholipase C activityGO:001086310.5FGF2, PDGFRB
5positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:003809110.5PDGFRB, VEGFA
6positive regulation of positive chemotaxisGO:005092710.5KDR, VEGFA
7positive regulation of chemotaxisGO:005092110.5PDGFRB, TGFB1
8cell migration involved in sprouting angiogenesisGO:000204210.4FGF2, KDR, VEGFA
9positive regulation of blood vessel endothelial cell migrationGO:004353610.4FGF2, TGFB1, VEGFA
10positive regulation of cell divisionGO:005178110.4FGF2, TGFB1, VEGFA
11lens fiber cell differentiationGO:007030610.4SIX3, TGFB1
12positive regulation of endothelial cell migrationGO:001059510.3FGF2, KDR, VEGFA
13positive regulation of epithelial cell proliferationGO:005067910.3FGF2, TGFB1, VEGFA
14extracellular matrix disassemblyGO:002261710.3MMP3, MMP9, TIMP2
15angiogenesisGO:000152510.2FGF2, KDR, RNF213, VEGFA
16positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.2FGF2, PDGFRB, TGFB1
17positive regulation of endothelial cell proliferationGO:000193810.0FGF2, KDR, RPTOR, VEGFA
18positive regulation of MAP kinase activityGO:00434069.9FGF2, PDGFRB, TGFB1, VEGFA
19positive regulation of cell migrationGO:00303359.9KDR, PDGFRB, TGFB1, VEGFA
20positive regulation of cell proliferationGO:00082849.7FGF2, KDR, PDGFRB, TGFB1, VEGFA
21wound healingGO:00420609.6FGF2, PDGFRB, TGFB1
22positive regulation of protein phosphorylationGO:00019349.5FGF2, KDR, MMP9, TGFB1, VEGFA

Molecular functions related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.9PDGFRB, VEGFA

Sources for Moyamoya Disease

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2CDC
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