MCID: MYM002
MIFTS: 55

Moyamoya Disease malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases categories

Aliases & Classifications for Moyamoya Disease

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Sources:
49OMIM, 10Disease Ontology, 11diseasecard, 45NIH Rare Diseases, 23Genetics Home Reference, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Moyamoya Disease:

Name: Moyamoya Disease 49 10 11 45 23 46 47 12 51 65 36
Spontaneous Occlusion of the Circle of Willis 45 23
Progressive Intracranial Arterial Occlusion 10 23
Moyamoya Disease 1 45 65
Moyamoya Disease 3 45 65
Moyamoya Disease 2 45 65
Progressive Intracranial Occlusive Arteropathy 23
 
Cerebrovascular Moyamoya Disease 23
Moyamoya Disease, Secondary 45
Moyamoya Disease, Primary 45
Moyamoya Syndrome 45
Moya-Moya Disease 23
Mymy 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
moyamoya disease:
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (France); Age of onset: All ages


External Ids:

OMIM49 252350
Disease Ontology10 DOID:13099
NCIt42 C84895
MeSH36 D009072
ICD9CM29 437.5
SNOMED-CT59 89142007, 69116000
Orphanet51 2573
ICD10 via Orphanet28 I67.5
MESH via Orphanet37 C536991, D009072
UMLS via Orphanet66 C0026654, C2931384
ICD1027 I67.5

Summaries for Moyamoya Disease

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NIH Rare Diseases:45 Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. the name "moyamoya" means "puff of smoke" in japanese and describes the look of the tangled vessels that form to compensate for the blockage. this condition usually affects children, but can affect adults. affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (tias) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. researchers believe that moyamoya disease is an inherited condition because it tends to run in families.moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, sturge-weber syndrome, and tuberous sclerosis. last updated: 7/1/2014

MalaCards based summary: Moyamoya Disease, also known as spontaneous occlusion of the circle of willis, is related to vascular disease and myocardial infarction, and has symptoms including seizures, ventriculomegaly and cognitive impairment. An important gene associated with Moyamoya Disease is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and VEGF ligand-receptor interactions. Affiliated tissues include brain, testes and endothelial, and related mouse phenotypes are muscle and respiratory system.

Disease Ontology:10 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. blood flow is blocked by the constriction and also by blood clots.

NINDS:46 Moyamoya disease is a rare, progressive cerebrovascular disorder caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name ?moyamoya? means ?puff of smoke? in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage.

Genetics Home Reference:23 Moyamoya disease is a disorder of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. These vessels, which provide oxygen-rich blood to the brain, narrow over time. Narrowing of these vessels reduces blood flow in the brain. In an attempt to compensate, new networks of small, fragile blood vessels form. These networks, visualized by a particular test called an angiogram, resemble puffs of smoke, which is how the condition got its name: "moyamoya" is an expression meaning "something hazy like a puff of smoke" in Japanese.

OMIM:49 Moyamoya is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion... (252350) more...

Wikipedia:68 Moyamoya syndrome is a disease in which certain arteries in the brain are constricted. Blood flow is... more...

Related Diseases for Moyamoya Disease

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Diseases in the Moyamoya Disease family:

Moyamoya Disease 3 Moyamoya Disease 5
Moyamoya Disease 2

Diseases related to Moyamoya Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease30.2FGF2, KDR, VEGFA
2myocardial infarction29.6MMP3, MMP9, MTHFR, TIMP1, VEGFA
3cerebritis10.9
4aneurysm10.7
5moyamoya disease 210.5
6moyamoya disease 510.5
7moyamoya disease 310.5
8ischemia10.4
9carotid artery occlusion10.4
10endotheliitis10.4
11pseudoxanthoma elasticum10.4
12dystonia10.4
13hemiplegia10.4
14myoclonus10.4
15rheumatoid vasculitis10.3MMP3, MMP9
16moyamoya 6 with achalasia10.3
17graves' disease10.3
18choroiditis10.3
19cerebral artery occlusion10.3
20arteriovenous malformation10.3
21down syndrome10.3
22neurofibromatosis10.3
23cerebrovascular disease10.3
24retinal drusen10.3MMP3, MMP9
25neurofibromatosis, type 110.3
26renovascular hypertension10.3
27artery disease10.3
28intracranial aneurysm10.3
29headache10.3
30moyamoya disease with early-onset achalasia10.3
31protein c deficiency10.2
32ovary transitional cell carcinoma10.2MMP3, MMP9, TIMP2
33colorectal adenoma10.2MMP9, TIMP1
34infiltrating angiolipoma10.2MMP9, VEGFA
35carcinoma arising in nasal papillomatosis10.2MMP9, VEGFA
36desquamative interstitial pneumonia10.2MMP9, TIMP1
37pelizaeus-merzbacher-like disease due to gjc2 mutation10.2SIX3, ZIC2
38diabetic neuropathy10.2MMP9, TGFB1
39tinea nigra10.2MMP9, TIMP1
40alobar holoprosencephaly10.2SIX3, ZIC2
41familial isolated hypoparathyroidism due to impaired pth secretion10.2FGF2, NUDT6
42stroke, ischemic10.2
43peripheral vascular disease10.2
44carotid artery disease10.2
45central nervous system disease10.2
46cerebral arterial disease10.2
47nervous system disease10.2
48prion disease10.2
49hemiplegic migraine10.2
50mushroom workers' lung10.2MMP9, VEGFA

Graphical network of the top 20 diseases related to Moyamoya Disease:



Diseases related to moyamoya disease

Symptoms for Moyamoya Disease

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Symptoms by clinical synopsis from OMIM:

252350

Clinical features from OMIM:

252350

Symptoms:

 51
  • vascular anomalies of skin/mucosae
  • autosomal recessive inheritance
  • dilated cerebral ventricles without hydrocephaly
  • cerebral vascular anomalies
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability

HPO human phenotypes related to Moyamoya Disease:

(show all 7)
id Description Frequency HPO Source Accession
1 seizures typical (50%) HP:0001250
2 ventriculomegaly typical (50%) HP:0002119
3 cognitive impairment typical (50%) HP:0100543
4 abnormality of the cerebral vasculature typical (50%) HP:0100659
5 autosomal recessive inheritance HP:0000007
6 telangiectasia HP:0001009
7 inflammatory arteriopathy HP:0005291

Drugs & Therapeutics for Moyamoya Disease

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Drugs for Moyamoya Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
XylometazolineapprovedPhase 364526-36-35709
Synonyms:
 
Balminil
Xylomethazoline
2
Sevofluraneapproved38128523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
3Xenon47
4Anesthetics, Inhalation456

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1The Adult Hemorrhagic Moyamoya Surgery StudyActive, not recruitingNCT02319980Phase 3
2Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCompletedNCT01419275
3Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic StrokeRecruitingNCT02074111
4Characteristics and Outcomes of Childhood Moyamoya in the UKRecruitingNCT02434302
5Subclavian Vein catheterization_Seldinger Vs Modified SeldingerRecruitingNCT02090010
6Stroke Imaging Package StudyRecruitingNCT02485275
7Characterizing Hemodynamic Compensation in Patients With Intracranial StenosisRecruitingNCT02506907
8The Role of Cerebral Hemodynamics in Moyamoya DiseaseActive, not recruitingNCT00629915
9Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE SyndromeActive, not recruitingNCT01018082
10Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing SurgeryNot yet recruitingNCT02305407
11Sevoflurane and Hyperperfusion SyndromeNot yet recruitingNCT02510586

Search NIH Clinical Center for Moyamoya Disease


Cochrane evidence based reviews: Moyamoya Disease

Genetic Tests for Moyamoya Disease

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Anatomical Context for Moyamoya Disease

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MalaCards organs/tissues related to Moyamoya Disease:

33
Brain, Testes, Endothelial, Skin, Smooth muscle, Thyroid, Bone

Animal Models for Moyamoya Disease or affiliated genes

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MGI Mouse Phenotypes related to Moyamoya Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6ACTA2, FGF2, KDR, MMP9, RPTOR, TGFB1
2MP:00053888.3KDR, MMP9, RAI1, SIX3, TGFB1, TIMP1
3MP:00053918.0ACTA2, FGF2, KDR, MMP9, MTHFR, SIX3
4MP:00053867.8FGF2, KDR, MMP9, RAI1, RPTOR, TGFB1
5MP:00053907.6FGF2, KDR, MMP3, MMP9, MTHFR, RAI1
6MP:00053977.3FGF2, KDR, MMP3, MMP9, RPTOR, TGFB1
7MP:00036317.0FGF2, KDR, MMP3, MMP9, MTHFR, RAI1
8MP:00053766.8FGF2, KDR, MMP3, MMP9, MTHFR, RAI1

Publications for Moyamoya Disease

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Articles related to Moyamoya Disease:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Surgical Management of Giant Basilar Tip Aneurysm Associated with Moyamoya Disease: A Case Report and Literature Review. (25862110)
2015
2
Coronary heart disease in moyamoya disease: are they concomitant or coincidence? (25829816)
2015
3
Pretransplant management of basilar artery aneurysm and moyamoya disease in a child with Alagille syndrome. (26043700)
2015
4
Anesthetic factors and outcome in children undergoing indirect revascularization procedure for moyamoya disease: An Indian perspective. (26448228)
2015
5
Moyamoya disease: A comparison of long term outcome of conservative and surgical treatment in India. (24183032)
2014
6
The collateral circulation in pediatric moyamoya disease. (25378261)
2014
7
Perfusion characteristics of moyamoya disease: an anatomically and clinically oriented analysis and comparison. (24193795)
2014
8
The natural clinical course of hemodynamically stable adult moyamoya disease. (25361479)
2014
9
The roles of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms in moyamoya disease patients. (25098357)
2014
10
Cerebral arteriovenous malformation associated with moyamoya disease. (25371789)
2014
11
The genetics of moyamoya disease: recent insights into the pathogenesis of the disease. (23149961)
2013
12
Hemodynamics and changes after STA-MCA anastomosis in moyamoya disease and atherosclerotic cerebrovascular disease measured by micro-Doppler ultrasonography. (23192651)
2013
13
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
14
Rapid progression of cerebral infarction after intraventricular hemorrhage in adult moyamoya disease. (24379948)
2013
15
Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease. (23652271)
2013
16
Incidence, locations, and longitudinal course of silent microbleeds in moyamoya disease: a prospective T2*-weighted MRI study. (23223508)
2013
17
Role of Burr Hole Surgery in Patients with Moyamoya Disease. (23920308)
2013
18
Effect of delayed transit time on arterial spin labeling: correlation with dynamic susceptibility contrast perfusion magnetic resonance in moyamoya disease. (23764569)
2013
19
Moyamoya disease with exaggerated startle response: A rare co-occurrence. (24339629)
2013
20
Prevalence and characteristics of concurrent down syndrome in patients with moyamoya disease. (23149966)
2013
21
Impaired dynamic cerebral autoregulation in Moyamoya disease. (23731503)
2013
22
Lessons learned from moyamoya disease: outcome of direct/indirect revascularization surgery for 150 affected hemispheres. (22688070)
2012
23
Posterior auricular artery-middle cerebral artery bypass for additional surgery of moyamoya disease. (22089809)
2012
24
Sex differences in clinical presentation and treatment outcomes in Moyamoya disease. (22718024)
2012
25
Posterior circulation and high prevalence of ischemic stroke among young pediatric patients with Moyamoya disease: evidence of angiography-based differences by age at diagnosis. (20801761)
2011
26
Increased levels of circulating SDF-1I+ and CD34+ CXCR4+ cells in patients with moyamoya disease. (21435112)
2011
27
Neurocognitive profiles of children with moyamoya disease before and after surgical intervention. (21178347)
2011
28
Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population. (20948207)
2010
29
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
30
Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease. (19774676)
2010
31
Endovascular treatment of intracranial aneurysms associated with moyamoya disease or moyamoya syndrome. (20977854)
2010
32
Incidence and pathogenesis of transient cheiro-oral syndrome after surgical revascularization for moyamoya disease. (20881569)
2010
33
Presumed perinatal stroke in a child with Down syndrome and moyamoya disease. (19583743)
2010
34
Computed tomographic perfusion in assessing postoperative revascularization in moyamoya disease. (20860934)
2010
35
Moyamoya disease: a clinical spectrum, literature review and case series from a tertiary care hospital in Pakistan. (19368734)
2009
36
Moyamoya disease: case report and literature review. (19861596)
2009
37
Surgical management of moyamoya disease: a review. (19335133)
2009
38
Laser Doppler flowmeter study on regional cerebral blood flow in early stage after standard superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease. (20079151)
2009
39
Moyamoya disease and moyamoya syndrome. (19571294)
2009
40
Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease. (19095988)
2009
41
Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease. (19147196)
2009
42
Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease. (18612318)
2008
43
Effect of preoperative skull block on pediatric moyamoya disease. (18590393)
2008
44
Moyamoya disease associated with hemoglobin Fairfax and beta-thalassemia. (18206795)
2008
45
Moyamoya disease and aortic coarctation in a patient with common brachiocephalic trunk. (17347086)
2007
46
Sudden cortical blindness in an adult with moyamoya disease. (17320646)
2007
47
Stenosis of the proximal external carotid artery in an adult with moyamoya disease: moyamoya or atherosclerotic change? (17721051)
2007
48
Basal meningoencephalocele, anomaly of optic disc and panhypopituitarism in association with moyamoya disease. (11070437)
2000
49
Angiogenic factors in moyamoya disease. (8969773)
1996
50
Iodine-123 IMP SPECT before and after bypass surgery in a patient with occlusion of left anterior and middle cerebral arteries with basal abnormal telangiectasis (unilateral Moyamoya disease). (3275095)
1987

Variations for Moyamoya Disease

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Clinvar genetic disease variations for Moyamoya Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NM_001613.2(ACTA2): c.773G> A (p.Arg258His)single nucleotide variantPathogenicrs121434527GRCh37Chr 10, 90699299: 90699299
2NM_001141945.1(ACTA2): c.772C> T (p.Arg258Cys)single nucleotide variantPathogenicrs121434528GRCh37Chr 10, 90699300: 90699300
3NM_001256071.2(RNF213): c.12343_12345delAAA (p.Lys4115del)deletionLikely pathogenicrs797045187GRCh37Chr 17, 78343585: 78343587
4ACTA2NM_001613.2(ACTA2): c.536G> A (p.Arg179His)single nucleotide variantPathogenicrs387906592GRCh37Chr 10, 90701066: 90701066
5RNF213RNF213, ARG4859LYSsingle nucleotide variantrisk factor
6NM_001256071.2(RNF213): c.14429G> A (p.Arg4810Lys)single nucleotide variantLikely pathogenic, risk factorrs112735431GRCh37Chr 17, 78358945: 78358945
7NM_001256071.2(RNF213): c.12037G> A (p.Asp4013Asn)single nucleotide variantLikely pathogenic, risk factorrs397514563GRCh37Chr 17, 78341825: 78341825

Expression for genes affiliated with Moyamoya Disease

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Search GEO for disease gene expression data for Moyamoya Disease.

Pathways for genes affiliated with Moyamoya Disease

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Pathways related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP3, MMP9, TIMP2
2
Show member pathways
9.7KDR, VEGFA
39.5MMP3, TGFB1, VEGFA
49.5FGF2, TGFB1, VEGFA
59.4FGF2, KDR, VEGFA
69.4FGF2, KDR, VEGFA
7
Show member pathways
9.4FGF2, KDR, VEGFA
8
Show member pathways
9.4MMP3, MMP9, TIMP1, TIMP2
99.4MMP3, MMP9, TIMP1, TIMP2
109.4FGF2, KDR, TGFB1
119.3KDR, TIMP1, VEGFA
12
Show member pathways
9.2ACTA2, FGF2, KDR, VEGFA
139.2FGF2, MMP9, TGFB1, VEGFA
149.0FGF2, KDR, TGFB1, VEGFA
15
Angiogenesis (WikiPathways)
Show member pathways
8.9FGF2, KDR, TGFB1, VEGFA
168.8FGF2, KDR, RPTOR, TIMP1, VEGFA
178.8FGF2, KDR, MMP9, TGFB1, VEGFA
18
Show member pathways
8.3FGF2, KDR, MMP3, MMP9, TGFB1, TIMP1
19
Angiogenesis (CST)
Show member pathways
8.3FGF2, KDR, MMP3, MMP9, TGFB1, TIMP1
20
Show member pathways
8.2FGF2, KDR, NUDT6, TGFB1, TIMP1, TIMP2
21
Show member pathways
8.0ACTA2, FGF2, KDR, NUDT6, TGFB1, TIMP1
22
Show member pathways
8.0ACTA2, FGF2, KDR, NUDT6, TGFB1, TIMP1
23
Show member pathways
7.9FGF2, KDR, NUDT6, RPTOR, TGFB1, TIMP1
24
Show member pathways
7.6ACTA2, FGF2, KDR, NUDT6, TGFB1, TIMP1
25
Show member pathways
7.1ACTA2, FGF2, KDR, MMP3, MMP9, NUDT6

GO Terms for genes affiliated with Moyamoya Disease

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Cellular components related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.9TGFB1, TIMP1, VEGFA
2proteinaceous extracellular matrixGO:00055788.7MMP3, MMP9, TGFB1, TIMP1, TIMP2, VEGFA
3extracellular spaceGO:00056158.2ACTA2, FGF2, MMP3, MMP9, TGFB1, TIMP1
4extracellular regionGO:00055767.6FGF2, KDR, MMP3, MMP9, TGFB1, TIMP1

Biological processes related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of metalloenzyme activityGO:004855310.5TIMP1, TIMP2
2negative regulation of membrane protein ectodomain proteolysisGO:005104510.5TIMP1, TIMP2
3negative regulation of blood vessel endothelial cell migrationGO:004353710.4FGF2, TGFB1
4hyaluronan catabolic processGO:003021410.4FGF2, TGFB1
5vascular endothelial growth factor signaling pathwayGO:003808410.3KDR, VEGFA
6regulation of hematopoietic progenitor cell differentiationGO:190153210.3KDR, VEGFA
7positive regulation of positive chemotaxisGO:005092710.3KDR, VEGFA
8surfactant homeostasisGO:004312910.3KDR, VEGFA
9macrophage differentiationGO:003022510.3MMP9, VEGFA
10regulation of endothelial cell differentiationGO:004560110.3KDR, VEGFA
11positive regulation of vascular permeabilityGO:004311710.3TGFB1, VEGFA
12lens fiber cell differentiationGO:007030610.3SIX3, TGFB1
13negative regulation of cell-cell adhesionGO:002240810.3TGFB1, VEGFA
14cell activationGO:000177510.2TGFB1, TIMP1
15positive regulation of blood vessel endothelial cell migrationGO:004353610.1FGF2, TGFB1, VEGFA
16cell migration involved in sprouting angiogenesisGO:000204210.1FGF2, KDR, VEGFA
17positive regulation of endothelial cell migrationGO:001059510.0FGF2, KDR, VEGFA
18platelet degranulationGO:00025769.9TGFB1, TIMP1, VEGFA
19positive regulation of MAP kinase activityGO:00434069.8FGF2, TGFB1, VEGFA
20positive regulation of angiogenesisGO:00457669.8FGF2, KDR, VEGFA
21lung developmentGO:00303249.7FGF2, KDR, VEGFA
22positive regulation of epithelial cell proliferationGO:00506799.6FGF2, KDR, TGFB1, VEGFA
23positive regulation of gene expressionGO:00106289.5ACTA2, FGF2, TGFB1, VEGFA
24positive regulation of endothelial cell proliferationGO:00019389.5FGF2, KDR, RPTOR, VEGFA
25wound healingGO:00420609.5FGF2, TGFB1, TIMP1
26agingGO:00075689.4FGF2, TGFB1, TIMP1, TIMP2
27extracellular matrix disassemblyGO:00226179.3MMP3, MMP9, TIMP1, TIMP2
28positive regulation of protein phosphorylationGO:00019349.2FGF2, KDR, MMP9, TGFB1, VEGFA
29positive regulation of cell proliferationGO:00082848.9FGF2, KDR, TGFB1, TIMP1, VEGFA
30extracellular matrix organizationGO:00301988.3FGF2, KDR, MMP3, MMP9, TGFB1, TIMP1

Molecular functions related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:000819110.1TIMP1, TIMP2
2cytokine activityGO:00051259.1FGF2, TGFB1, TIMP1, VEGFA
3growth factor activityGO:00080838.5FGF2, NUDT6, TGFB1, TIMP1, VEGFA

Sources for Moyamoya Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet