MCID: MYM002
MIFTS: 60

Moyamoya Disease malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Moyamoya Disease

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 48NINDS, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Moyamoya Disease:

Name: Moyamoya Disease 51 11 47 25 48 53 12 49 38 13 67
Moyamoya Disease 1 47 26 67
Spontaneous Occlusion of the Circle of Willis 47 25
Progressive Intracranial Arterial Occlusion 11 25
Moyamoya Disease 3 47 67
Moyamoya Disease 2 47 67
Moya-Moya Disease 25 26
 
Progressive Intracranial Occlusive Arteropathy 25
Cerebrovascular Moyamoya Disease 25
Moyamoya Disease, Secondary 47
Moyamoya Disease, Primary 47
Moyamoya Syndrome 47
Mymy 47

Characteristics:

Orphanet epidemiological data:

53
moyamoya disease:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial,X-linked recessive; Prevalence: 1-9/1000000 (France); Age of onset: All ages

HPO:

63
moyamoya disease:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM51 252350
Disease Ontology11 DOID:13099
ICD1029 I67.5
ICD9CM31 437.5
MeSH38 D009072
SNOMED-CT61 69116000, 89142007
NCIt44 C84895
Orphanet53 ORPHA2573
MESH via Orphanet39 C536991, D009072
UMLS via Orphanet68 C0026654, C2931384
ICD10 via Orphanet30 I67.5

Summaries for Moyamoya Disease

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OMIM:51 Moyamoya is the name given to a cerebral angiographic picture of bilateral intracranial carotid artery occlusion... (252350) more...

MalaCards based summary: Moyamoya Disease, also known as moyamoya disease 1, is related to myocardial infarction and moyamoya disease 5, and has symptoms including seizures, ventriculomegaly and cognitive impairment. An important gene associated with Moyamoya Disease is RNF213 (Ring Finger Protein 213), and among its related pathways are VEGF binds to VEGFR leading to receptor dimerization and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, testes and endothelial, and related mouse phenotypes are respiratory system and muscle.

Disease Ontology:11 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.

Genetics Home Reference:25 Moyamoya disease is a disorder of blood vessels in the brain, specifically the internal carotid arteries and the arteries that branch from them. These vessels, which provide oxygen-rich blood to the brain, narrow over time. Narrowing of these vessels reduces blood flow in the brain. In an attempt to compensate, new networks of small, fragile blood vessels form. These networks, visualized by a particular test called an angiogram, resemble puffs of smoke, which is how the condition got its name: "moyamoya" is an expression meaning "something hazy like a puff of smoke" in Japanese.

NIH Rare Diseases:47 Moyamoya disease is a rare, progressive, blood vessel disease caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name moyamoya means puff of smoke in Japanese and describes the look of the tangled vessels that form to compensate for the blockage. This condition usually affects children, but can affect adults. Affected people are at increased risk for blood clots, strokes, and transient ischemic attacks (TIAs) which are frequently accompanied by seizures and muscular weakness, or paralysis on one side of the body. Affected people may also have disturbed consciousness, speech deficits (usually aphasia), sensory and cognitive impairments, involuntary movements, and vision problems. Researchers believe that Moyamoya disease is an inherited condition because it tends to run in families.Moyamoya syndrome is a related term that refers to cases of moyamoya disease that occur in association with other conditions or risk factors, such as neurofibromatosis, tuberculosis meningitis, sickle cell disease, leptospirosis, brain tumors, Sturge-Weber syndrome, and tuberous sclerosis. Last updated: 7/1/2014

NINDS:48 Moyamoya disease is a rare, progressive cerebrovascular disorder caused by blocked arteries at the base of the brain in an area called the basal ganglia. The name ?moyamoya? means ?puff of smoke? in Japanese and describes the look of the tangle of tiny vessels formed to compensate for the blockage.

Wikipedia:70 Moyamoya disease is a disease in which certain arteries in the brain are constricted. Blood flow is... more...

Related Diseases for Moyamoya Disease

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Diseases in the Moyamoya Disease family:

Moyamoya Disease 3 Moyamoya Disease 5
Moyamoya Disease 2

Diseases related to Moyamoya Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction28.4GUCY1A3, MMP3, MMP9, MTHFR, TGFB1, VEGFA
2moyamoya disease 512.2
3moyamoya disease 212.2
4moyamoya disease 312.2
5moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism12.2
6moyamoya 6 with achalasia11.9
7rhizomelic dysplasia, scoliosis, and retinitis pigmentosa10.6MMP3, MMP9
8acute salpingo-oophoritis10.5ACTA2, GUCY1A3, RNF213
9cerebritis10.5
10pathological gambling10.5MMP3, MMP9
11thrombocytosis10.4FGF2, TGFB1
12diamond-blackfan anemia10.4MMP9, TGFB1
13pericardial mesothelioma10.4FGF2, TGFB1
14colorectal adenoma10.4FGF2, VEGFA
15pineal region yolk sac tumor10.4MMP3, MMP9, TIMP2
16schwannomatosis10.4MMP3, MMP9, TIMP2
17granulomatous orchitis10.4FGF2, MMP3, TGFB1
18vitreous abscess10.4FGF2, TGFB1, VEGFA
19intestinal benign neoplasm10.4MMP9, TIMP2, VEGFA
20adenosine monophosphate deaminase 1 deficiency10.4MMP9, TIMP2, VEGFA
21chorioretinitis10.4MMP3, MMP9, VEGFA
22exudative vitreoretinopathy 110.4FGF2, TGFB1, TIMP2
23vertebral artery occlusion10.3MMP3, MMP9, VEGFA
24impetigo herpetiformis10.3MMP3, MMP9, TIMP2
25emphysematous cholecystitis10.3MMP9, VEGFA
26dental pulp disease10.3FGF2, TGFB1, VEGFA
27silicosiderosis10.3KDR, VEGFA
28neuropathy, hereditary sensory and autonomic, type vi10.3FGF2, MMP9, VEGFA
29malignant giant cell tumor10.3MMP3, MMP9, VEGFA
30keratopathy10.3TGFB1, TIMP2
31dysostosis10.2MMP9, TGFB1, VEGFA
32gastric small cell carcinoma10.2FGF2, KDR, VEGFA
33epidural abscess10.2FGF2, KDR, VEGFA
34plague10.2MMP3, MMP9
35aneurysm10.2
36hydromyelia10.2MTHFR, VEGFA
37naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.2FGF2, TGFB1, TIMP2, VEGFA
38lung carcinoma in situ10.2FGF2, KDR, VEGFA
39gallbladder papillomatosis10.2MMP9, TGFB1, VEGFA
40renal fibrosis10.2FGF2, KDR, VEGFA
41bladder urachal carcinoma10.2KDR, MMP9, VEGFA
42ameloblastic carcinoma10.2MMP9, MTHFR
43villous adenoma10.2MMP9, TGFB1, VEGFA
44hematopoietic stem cell transplantation10.2FGF2, KDR, VEGFA
45lobular neoplasia10.1MMP9, TGFB1, TIMP2, VEGFA
46hemopneumothorax10.1MMP9, VEGFA
47gemistocytic astrocytoma10.1FGF2, MMP9, TGFB1, VEGFA
48autoimmune hepatitis10.1MMP3, MMP9, TGFB1, VEGFA
49citrullinemia, adult-onset type ii10.1FGF2, KDR, VEGFA
50endotheliitis10.0

Graphical network of the top 20 diseases related to Moyamoya Disease:



Diseases related to moyamoya disease

Symptoms for Moyamoya Disease

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Symptoms by clinical synopsis from OMIM:

252350

Clinical features from OMIM:

252350

Human phenotypes related to Moyamoya Disease:

 63 53 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures63 53 typical (50%) Frequent (79-30%) HP:0001250
2 ventriculomegaly63 53 typical (50%) Frequent (79-30%) HP:0002119
3 cognitive impairment63 typical (50%) HP:0100543
4 abnormality of the cerebral vasculature63 53 typical (50%) Frequent (79-30%) HP:0100659
5 telangiectasia63 53 Very frequent (99-80%) HP:0001009
6 inflammatory arteriopathy63 HP:0005291
7 intellectual disability53 Frequent (79-30%)

Drugs & Therapeutics for Moyamoya Disease

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Drugs for Moyamoya Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
XylometazolineapprovedPhase 372526-36-35709
Synonyms:
 
Balminil
Xylomethazoline
2
Sevofluraneapproved, vet_approved47928523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
3
Glucosamineapproved, Nutraceutical1823416-24-8439213
Synonyms:
(+)-2-amino-2-deoxy-D-glucopyranose
(2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(2S,5R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
14257-69-3
2-Amino-2-deoxy-D-Glucose
2-Amino-2-deoxy-D-glucopyranose
2-Amino-2-deoxy-D-glucose
2-Amino-2-deoxy-beta-D-glucopyranose
2-Amino-2-deoxyglucose
2-Aminoglucose
2-Deoxy-2-amino-D-glucose
2-Deoxy-2-aminoglucose
2-amino-2-deoxy-D-glucopyranose
2-amino-2-deoxyglucose
2351-15-7
28905-10-4
2B4D44B2-D5AC-4DA4-9BE6-A4AE9574E4A6
3416-24-8
4-04-00-02017 (Beilstein Handbook Reference)
58-87-7
58267-75-7
6490-70-6
880765-44-6
90-77-7
911653-84-4
AC1L2D1C
AC1L96WB
AC1L9B8P
AC1Q4UBH
BRN 1724602
BSPBio_002086
C00329
C08349
CHEBI:28393
CHEBI:47977
CHEMBL234432
CID18897
CID439213
CID441477
CPD0-1193
Chitosamine
Cosamin
D-(+)-Glucosamine
 
D-Glucosamine
D-glucosamine
D04334
DB01296
DivK1c_000261
EINECS 222-311-2
GCS
Glucosamina
Glucosamina [INN-Spanish]
Glucosamine (USAN/INN)
Glucosamine [USAN:INN]
Glucosaminum
Glucosaminum [INN-Latin]
HMS500N03
HSDB 7469
IDI1_000261
InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6-/m1/s1
KBio1_000261
KBio2_001311
KBio2_003879
KBio2_006447
KBio3_001306
KBioGR_000970
KBioSS_001311
LS-71671
MolPort-002-507-091
MolPort-003-944-937
NCGC00164421-01
NCGC00178826-01
NINDS_000261
SPBio_000477
STK801823
Spectrum2_000519
Spectrum3_000443
Spectrum4_000565
Spectrum5_000756
Spectrum_000831
Viartril-S
beta-D-Glucosamine
bmse000247
chitosamine
glucosamine
nchembio.189-comp4
nchembio.2007.41-comp7
nchembio.412-comp5
partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
4Lipid Regulating Agents2702
5Anticoagulants2516
6Hypolipidemic Agents2721
7Hypoglycemic Agents5733
8Antimetabolites11774
9Glucuronyl glucosamine glycan sulfate132
10Fibrinolytic Agents2317
11Xenon66
12Antihypertensive Agents4095
13Anticonvulsants2620
14Vasodilator Agents3438
15Platelet Aggregation Inhibitors2419
16Central Nervous System Depressants12806
17Anesthetics, General2787
18Anesthetics9001
19Anesthetics, Inhalation649

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1The Adult Hemorrhagic Moyamoya Surgery StudyActive, not recruitingNCT02319980Phase 3
2Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic StrokeUnknown statusNCT02074111
3Subclavian Vein catheterization_Seldinger Vs Modified SeldingerUnknown statusNCT02090010
4Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCompletedNCT01419275
5Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya DiseaseRecruitingNCT02982135
6Characteristics and Outcomes of Childhood Moyamoya in the UKRecruitingNCT02434302
7Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing SurgeryRecruitingNCT02305407
8Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRIRecruitingNCT02914288
9Characterizing Hemodynamic Compensation in Patients With Intracranial StenosisRecruitingNCT02506907
10Stroke Imaging Package StudyRecruitingNCT02485275
11The Role of Cerebral Hemodynamics in Moyamoya DiseaseActive, not recruitingNCT00629915
12Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE SyndromeActive, not recruitingNCT01018082
13Sevoflurane and Hyperperfusion SyndromeNot yet recruitingNCT02510586

Search NIH Clinical Center for Moyamoya Disease


Cochrane evidence based reviews: moyamoya disease

Genetic Tests for Moyamoya Disease

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Genetic tests related to Moyamoya Disease:

id Genetic test Affiliating Genes
1 Moyamoya Disease 126
2 Moyamoya Disease26

Anatomical Context for Moyamoya Disease

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MalaCards organs/tissues related to Moyamoya Disease:

35
Brain, Testes, Endothelial, Smooth muscle, Thyroid, Bone, Pituitary

Animal Models for Moyamoya Disease or affiliated genes

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MGI Mouse Phenotypes related to Moyamoya Disease:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7GUCY1A3, KDR, MMP9, RAI1, SHOC2, SIX3
2MP:00053698.6ACTA2, FGF2, GUCY1A3, KDR, MMP9, PDGFRB
3MP:00053858.4ACTA2, FGF2, GUCY1A3, KDR, MMP9, PDGFRB
4MP:00053978.4FGF2, GUCY1A3, KDR, MMP3, MMP9, PDGFRB
5MP:00053787.6KDR, MMP9, MTHFR, PDGFRB, RAI1, RNF213
6MP:00053907.5FGF2, KDR, MMP3, MMP9, MTHFR, PDGFRB
7MP:00036317.4FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
8MP:00053917.2ACTA2, FGF2, GUCY1A3, KDR, MMP9, MTHFR
9MP:00053767.2FGF2, GUCY1A3, KDR, MMP3, MMP9, MTHFR
10MP:00107686.5CRABP1, FGF2, GUCY1A3, KDR, MMP9, MTHFR

Publications for Moyamoya Disease

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Articles related to Moyamoya Disease:

(show top 50)    (show all 682)
idTitleAuthorsYear
1
Dystonia an unusual presentation in pediatric moyamoya disease: Imaging findings of a case. (27606018)
2016
2
Moyamoya Disease: A Review of Clinical Research. (27549666)
2016
3
A Case of Homocystinuria Misdiagnosed as Moyamoya Disease: A Case Report. (27330833)
2016
4
Prolonged Mean Transit Time Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Predicts Cerebrovascular Reserve Impairment in Patients with Moyamoya Disease. (27088711)
2016
5
Clinical features and long-term outcomes of unilateral moyamoya disease. (27647029)
2016
6
Surgical Management of Giant Basilar Tip Aneurysm Associated with Moyamoya Disease: A Case Report and Literature Review. (25862110)
2015
7
Coronary heart disease in moyamoya disease: are they concomitant or coincidence? (25829816)
2015
8
Pretransplant management of basilar artery aneurysm and moyamoya disease in a child with Alagille syndrome. (26043700)
2015
9
Cognitive Dysfunction Survey of the Japanese Patients with Moyamoya Disease (COSMO-JAPAN Study): Study Protocol. (25739435)
2015
10
Moyamoya disease: A comparison of long term outcome of conservative and surgical treatment in India. (24183032)
2014
11
The collateral circulation in pediatric moyamoya disease. (25378261)
2014
12
Perfusion characteristics of moyamoya disease: an anatomically and clinically oriented analysis and comparison. (24193795)
2014
13
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
14
Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease. (23652271)
2013
15
Incidence, locations, and longitudinal course of silent microbleeds in moyamoya disease: a prospective T2*-weighted MRI study. (23223508)
2013
16
Role of Burr Hole Surgery in Patients with Moyamoya Disease. (23920308)
2013
17
Effect of delayed transit time on arterial spin labeling: correlation with dynamic susceptibility contrast perfusion magnetic resonance in moyamoya disease. (23764569)
2013
18
Moyamoya disease with exaggerated startle response: A rare co-occurrence. (24339629)
2013
19
Impaired dynamic cerebral autoregulation in Moyamoya disease. (23731503)
2013
20
Diagnosis of moyamoya disease on magnetic resonance imaging: are flow voids in the basal ganglia an essential criterion for definitive diagnosis? (22939199)
2013
21
High-resolution MR technique can distinguish moyamoya disease from atherosclerotic occlusion. (23420895)
2013
22
High resolution MRI difference between moyamoya disease and intracranial atherosclerosis. (23789981)
2013
23
Value of cerebral oxygen saturation monitoring during cardiopulmonary bypass in an adult patient with moyamoya disease. (22209176)
2013
24
Sex differences in clinical presentation and treatment outcomes in Moyamoya disease. (22718024)
2012
25
Clinical features, surgical treatment and long-term outcome in adult patients with Moyamoya disease in China. (23146868)
2012
26
Transient crossed cerebellar diaschisis due to cerebral hyperperfusion following surgical revascularization for moyamoya disease: case report. (22688075)
2012
27
Long-term follow-up results in 142 adult patients with moyamoya disease according to management modality. (22476796)
2012
28
Increased levels of circulating SDF-1I+ and CD34+ CXCR4+ cells in patients with moyamoya disease. (21435112)
2011
29
Analysis of ACTA2 in European Moyamoya disease patients. (20970362)
2011
30
Moyamoya disease: a review of histopathology, biochemistry, and genetics. (21631222)
2011
31
Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population. (20948207)
2010
32
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
33
Computed tomographic perfusion in assessing postoperative revascularization in moyamoya disease. (20860934)
2010
34
Thalamo-perforating artery aneurysm in Moyamoya disease - case report. (20515265)
2010
35
Combined spinal-epidural anesthesia for cesarean section in a patient with Moyamoya disease -A case report-. (21286427)
2010
36
Moyamoya disease. (20589474)
2010
37
Moyamoya disease: a clinical spectrum, literature review and case series from a tertiary care hospital in Pakistan. (19368734)
2009
38
Moyamoya disease: case report and literature review. (19861596)
2009
39
Surgical management of moyamoya disease: a review. (19335133)
2009
40
Laser Doppler flowmeter study on regional cerebral blood flow in early stage after standard superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease. (20079151)
2009
41
Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease. (19095988)
2009
42
Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease. (19147196)
2009
43
Effect of preoperative skull block on pediatric moyamoya disease. (18590393)
2008
44
Moyamoya disease associated with hemoglobin Fairfax and beta-thalassemia. (18206795)
2008
45
Case of moyamoya disease in a patient with advanced acquired immunodeficiency syndrome. (18035245)
2007
46
Stenosis of the proximal external carotid artery in an adult with moyamoya disease: moyamoya or atherosclerotic change? (17721051)
2007
47
Expression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease. (17290185)
2007
48
Intracerebral hemorrhage after prophylactic revascularization in a patient with adult moyamoya disease. (17719983)
2007
49
Basal meningoencephalocele, anomaly of optic disc and panhypopituitarism in association with moyamoya disease. (11070437)
2000
50
Angiogenic factors in moyamoya disease. (8969773)
1996

Variations for Moyamoya Disease

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Copy number variations for Moyamoya Disease from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
110690517178774742DeletionMoyamoya disease

Expression for genes affiliated with Moyamoya Disease

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Search GEO for disease gene expression data for Moyamoya Disease.

Pathways for genes affiliated with Moyamoya Disease

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Pathways related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9KDR, VEGFA
29.8ACTA2, FGF2, TGFB1
39.7FGF2, KDR, VEGFA
49.7FGF2, TGFB1, VEGFA
59.6FGF2, KDR, TGFB1
69.6MMP3, TGFB1, VEGFA
79.6MMP3, MMP9, TIMP2
89.6MMP3, MMP9, TIMP2
9
Show member pathways
9.6MMP3, MMP9, TIMP2
109.6KDR, PDGFRB, VEGFA
119.4ACTA2, KDR, TGFB1, VEGFA
129.4FGF2, KDR, TGFB1, VEGFA
139.4FGF2, KDR, PDGFRB, VEGFA
149.3FGF2, MMP9, TGFB1, VEGFA
15
Show member pathways
9.1FGF2, KDR, PDGFRB, SHOC2, VEGFA
16
Show member pathways
9.1FGF2, KDR, MMP9, TIMP2, VEGFA
179.0FGF2, KDR, PDGFRB, TGFB1, VEGFA
189.0FGF2, KDR, PDGFRB, RPTOR, VEGFA
199.0FGF2, KDR, MMP9, TGFB1, VEGFA
208.9FGF2, MMP9, PDGFRB, TGFB1, VEGFA
21
Show member pathways
8.9ACTA2, FGF2, KDR, PDGFRB, TGFB1, TIMP2
22
Show member pathways
8.7FGF2, KDR, MMP3, MMP9, TGFB1, TIMP2
23
Show member pathways
8.4FGF2, KDR, MMP3, MMP9, PDGFRB, TGFB1
24
Show member pathways
8.4ACTA2, FGF2, GUCY1A3, KDR, PDGFRB, TGFB1
25
Show member pathways
7.9ACTA2, FGF2, KDR, MMP3, MMP9, PDGFRB

GO Terms for genes affiliated with Moyamoya Disease

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Cellular components related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.0MMP3, MMP9, TGFB1, TIMP2, VEGFA
2extracellular spaceGO:00056158.6ACTA2, FGF2, MMP3, MMP9, TGFB1, TIMP2

Biological processes related to Moyamoya Disease according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:001086310.6FGF2, PDGFRB
2positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.5KDR, VEGFA
3hyaluronan catabolic processGO:003021410.5FGF2, TGFB1
4positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:003809110.5PDGFRB, VEGFA
5positive regulation of positive chemotaxisGO:005092710.5KDR, VEGFA
6positive regulation of chemotaxisGO:005092110.4PDGFRB, TGFB1
7cell migration involved in sprouting angiogenesisGO:000204210.3FGF2, KDR, VEGFA
8positive regulation of blood vessel endothelial cell migrationGO:004353610.3FGF2, TGFB1, VEGFA
9positive regulation of endothelial cell migrationGO:001059510.3FGF2, KDR, VEGFA
10positive regulation of cell divisionGO:005178110.2FGF2, TGFB1, VEGFA
11positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.2FGF2, PDGFRB, TGFB1
12lens fiber cell differentiationGO:007030610.1SIX3, TGFB1
13negative regulation of blood vessel endothelial cell migrationGO:004353710.1FGF2, TGFB1
14extracellular matrix disassemblyGO:00226179.9MMP3, MMP9, TIMP2
15positive regulation of epithelial cell proliferationGO:00506799.9FGF2, TGFB1, VEGFA
16positive regulation of endothelial cell proliferationGO:00019389.7FGF2, KDR, RPTOR, VEGFA
17angiogenesisGO:00015259.7FGF2, KDR, RNF213, VEGFA
18wound healingGO:00420609.7FGF2, PDGFRB, TGFB1
19positive regulation of MAP kinase activityGO:00434069.6FGF2, PDGFRB, TGFB1, VEGFA
20positive regulation of protein phosphorylationGO:00019349.4FGF2, KDR, MMP9, TGFB1, VEGFA
21positive regulation of cell proliferationGO:00082849.0FGF2, KDR, PDGFRB, TGFB1, VEGFA
22positive regulation of cell migrationGO:00303358.9KDR, PDGFRB, TGFB1, VEGFA

Molecular functions related to Moyamoya Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.9PDGFRB, VEGFA

Sources for Moyamoya Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
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