MCID: MCN001
MIFTS: 54

Mucinous Adenocarcinoma malady

Cancer category

Summaries for Mucinous Adenocarcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which produce mucin.

MalaCards: Mucinous Adenocarcinoma, also known as mucin-producing adenocarcinoma, is related to adenocarcinoma and ovarian mucinous adenocarcinoma. An important gene associated with Mucinous Adenocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeleton remodeling Keratin filaments. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thymus and brain, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:64 Mucinous carcinoma is a type of cancer that arises from epithelial cells; these line certain internal... more...

Aliases & Classifications for Mucinous Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

mucinous adenocarcinoma 8 10
mucin-producing adenocarcinoma 8 61
pseudomyxoma peritonei with unknown primary site 8
mucin-secreting adenocarcinoma 8
mucin-secreting carcinoma 8
adenocarcinoma, mucinous 61
mucous carcinoma 8


External Ids:

Disease Ontology8 DOID:3030
NCIt40 C26712
SNOMED-CT57 900006, 72495009
MeSH35 D002288

Related Diseases for Mucinous Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0MUC5AC, MUC1, CDKN2A, CDX2, KRT4, KRT7
2ovarian mucinous adenocarcinoma31.1SLC45A3
3bladder adenocarcinoma31.0CDX2, SLC45A3
4pseudomyxoma peritonei30.9MUC2, MUC5AC, CDX2, KRT7, KRT20
5signet ring cell adenocarcinoma30.8MUC2, KRT7, KRT20
6teratoma30.8KRT7
7adenoma30.6AMACR, MUC2, TP53, ACPP, KRT20, KRT7
8neuroendocrine carcinoma30.4MUC1, CDX2, KRT7, KRT20
9ulcerative colitis30.2TP53
10mucinous cystadenocarcinoma30.2MUC1, KRT7, KRT20
11papillary carcinoma30.2KRT20, KRT7, MUC1, MUC2, AMACR
12colorectal cancer30.2AMACR, MUC2, MUC5AC, MUC1, CDKN2A, CDX2
13cystadenoma30.0KRT7
14adenocarcinoma in situ30.0CDKN2A
15sertoli cell tumor30.0MUC1, VIM
16sertoli-leydig cell tumor30.0MUC1, KRT7
17nephrogenic adenoma30.0AMACR, UPK3A, KRT7
18thymic carcinoma30.0MUC1, KRT7
19adenoid cystic carcinoma30.0VIM, MUC1, KRT7, KRT20
20transitional cell carcinoma30.0UPK3A, KRT7, KRT20, TP53
21bladder carcinoma30.0UPK3A, MUC2, CDKN2A, KRT20, TP53
22stomach cancer30.0AMACR, MUC2, MUC5AC, CDKN2A, CDX2, KRT20
23colon mucinous adenocarcinoma10.8
24appendix adenocarcinoma10.7
25renal pelvis adenocarcinoma10.7
26mucinous stomach adenocarcinoma10.6
27rectum mucinous adenocarcinoma10.5
28urachal adenocarcinoma10.5
29endometrial mucinous adenocarcinoma10.5
30bile duct mucinous adenocarcinoma10.4
31fallopian tube mucinous adenocarcinoma10.4
32ureter adenocarcinoma10.4
33urethra adenocarcinoma10.4
34breast adenocarcinoma10.3
35vulva adenocarcinoma10.3
36anal fistula10.3
37ovarian cystic teratoma10.3
38intussusception10.3
39villoglandular variant cervical mucinous adenocarcinoma10.3
40intestinal variant cervical mucinous adenocarcinoma10.3
41endocervical type cervical mucinous adenocarcinoma10.3
42signet ring cell variant cervical mucinous adenocarcinoma10.3
43uterine ligament mucinous adenocarcinoma10.3
44ampulla of vater mucinous adenocarcinoma10.3
45villous adenocarcinoma10.3
46large cell carcinoma10.3
47anal canal adenocarcinoma10.3
48thymus adenocarcinoma10.3
49urachal cyst10.3
50mucin-rich endometrial endometrioid adenocarcinoma10.2

Graphical network of the top 20 diseases related to Mucinous Adenocarcinoma:



Diseases related to mucinous adenocarcinoma

Clinical Features for Mucinous Adenocarcinoma

Drugs & Therapeutics for Mucinous Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mucinous Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Mucinous Adenocarcinoma

Search NIH Clinical Center for Mucinous Adenocarcinoma

Search CenterWatch for Mucinous Adenocarcinoma

Genetic Tests for Mucinous Adenocarcinoma

Anatomical Context for Mucinous Adenocarcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Mucinous Adenocarcinoma:

33
Lymph node, Thymus, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Breast, Skin, Ovary, Uterus, Placenta, Prostate, Testis, Cervix, T cells, Fetal brain, Tongue, Fetal liver, Fetal lung, Trachea, Bronchial epithelium, Appendix, Fetal thyroid, Uterus corpus, Testis leydig

Animal Models for Mucinous Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Mucinous Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CDX2, MUC5AC, MUC2, NEK8, UPK3A, AMACR
2MP:00053819.3TP53, MUC2, MUC5AC, MUC1, CDKN2A, CDX2

Publications for Mucinous Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Mucinous Adenocarcinoma:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Minor salivary gland mucinous adenocarcinoma of buccal mucosa - case report and review of the literature. (24375048)
2013
2
Pulmonary artery embolization for refractory hypoxemia caused by invasive mucinous adenocarcinoma. (23328554)
2013
3
Intra-abdominal mucinous adenocarcinoma of urachal origin: report of a case. (23689950)
2013
4
Two cases of mucinous adenocarcinoma of the stomach mistaken as submucosal tumor. (23396274)
2013
5
Pseudomyxoma peritonei due to mucinous adenocarcinoma of the appendix. (23971183)
2013
6
Mucinous adenocarcinoma arising from diffuse serrated adenoma of the appendix which mimics appendicular abscess. (23012662)
2012
7
Unusual isolated perineal recurrence in mucinous adenocarcinoma of the rectum after abdominoperineal resection: usefulness of dual-time-point FDG PET in evaluating mucinous tumors. (22955074)
2012
8
Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature. (23216975)
2012
9
Mucinous adenocarcinoma of the endometrium: case series and review of the literature. (22569105)
2012
10
Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. (22592533)
2012
11
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. (22569454)
2012
12
Primary mucinous adenocarcinoma of the testis. (22550498)
2012
13
Primary appendiceal mucinous adenocarcinoma in two first-degree relatives: case report and review. (21542938)
2011
14
Value of delayed PET imaging in mucinous adenocarcinoma rectum: should this be employed while evaluating mucinous tumors with FDG-PET? (21921347)
2011
15
Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma. (21422912)
2011
16
Mucinous adenocarcinoma and T-cell lymphoma in the small intestine of 2 Vietnamese potbellied pigs (Sus scrofa). (20974872)
2011
17
Mucinous adenocarcinoma showing different clinicopathological and molecular characteristics in relation to different colorectal cancer subgroups. (20532535)
2010
18
Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. (20184795)
2010
19
Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma. (21161940)
2010
20
Mucinous adenocarcinoma involving the ovary: comparative evaluation of the classification algorithms using tumor size and laterality. (20119573)
2010
21
Mucinous adenocarcinoma of the ovary. (20816501)
2010
22
CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas. (19786935)
2009
23
Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma. (18849918)
2008
24
Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). (19014441)
2008
25
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. (17349581)
2007
26
Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from a single institution. (17357864)
2007
27
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia. (17906614)
2007
28
Mucinous adenocarcinoma associated with chronic anal fistula reconstructed by gracilis myocutaneous flaps. (16969607)
2006
29
Combined positron emission tomography and computed tomography for the detection of recurrent ovarian mucinous adenocarcinoma. (15721446)
2005
30
Pancreatic mucinous adenocarcinoma with peritoneal metastases. (15990837)
2005
31
Mucinous adenocarcinoma of the renal pelvis associated with transitional cell carcinoma in the renal pelvis and the bladder. (15509208)
2004
32
Mucinous adenocarcinoma of the renal pelvis associated with lithiasis and chronic gout. (15029415)
2004
33
Defective mismatch repair in the pathogenesis of low-grade appendiceal mucinous neoplasms and adenocarcinomas. (15354187)
2004
34
A case of mucinous adenocarcinoma arising in long-standing multiple perianal and presacral fistulas. (15655599)
2004
35
Inferior head resection of the pancreas for noninvasive intraductal papillary mucinous adenocarcinoma. (15011879)
2004
36
Mucinous adenocarcinoma of the urachus]. (12731329)
2003
37
Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas. (12657951)
2003
38
Mucinous adenocarcinoma of ectopic breast tissue of the vulva. (12296762)
2002
39
Typical clinical and radiographic findings in a patient with longstanding malignant pseudomyxoma peritonei secondary to a mucinous adenocarcinoma. (12453339)
2002
40
Mucinous adenocarcinoma of the ovary metastatic to the eye: report of a case with diagnosis by fine needle aspiration biopsy. (11575663)
2001
41
Primary eyelid mucinous adenocarcinoma of eccrine origin. (10334028)
1999
42
Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. (9677464)
1998
43
Mucinous adenocarcinoma of the renal pelvis in natives of India. (9096276)
1997
44
Assessment of clinicopathologic features of colorectal mucinous adenocarcinoma. (8396358)
1993
45
Elderly man with hematuria and a pelvic mass. Mucinous adenocarcinoma of the urachus. (3036743)
1987
46
Mucinous adenocarcinoma of the esophagus metastatic to a spinal fusion. (3035722)
1987
47
Mucinous adenocarcinoma of the appendix presenting as an ovarian cystadenocarcinoma: case report and review of appendiceal neoplasms with ovarian metastases. (3023143)
1986
48
Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathologic study of four cases. (6309685)
1983
49
Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma. (4376755)
1974
50
Mucinous adenocarcinoma of the pelvis of the kidney. (21009420)
1946

Genetic Variations for Mucinous Adenocarcinoma

Expression for genes affiliated with Mucinous Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Mucinous Adenocarcinoma.

Pathways for genes affiliated with Mucinous Adenocarcinoma

Sources:
54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MUC5AC, MUC1, MUC2
210.1KRT4, VIM, KRT7
39.9VIM, CDKN2A, SLC45A3, TP53

Compounds for genes affiliated with Mucinous Adenocarcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1butyrate4510.8CDX2
2estrogen4510.7ACPP
3sialic acid4510.7KRT7
4carbohydrates4510.5MUC2, MUC5AC
5reticulin4510.5VIM, KRT7, MUC1
6temozolomide45 1111.5VIM, TP53, CDKN2A
7eosin4510.4MUC1, VIM
8crcs4510.4TP53, CDKN2A, MUC1, MUC2
9streptavidin4510.4KRT7, KRT20, AMACR
10acnu4510.4TP53, CDKN2A
11biotin45 11 2412.4VIM, AMACR, CDKN2A, MUC1
12roscovitine4510.4TP53, VIM, CDKN2A
13mucicarmine4510.4VIM, KRT20, MUC1, KRT7
14cytarabine45 50 1112.4CDKN2A, VIM, MUC1, TP53
15adriamycin4510.3TP53, MUC1, VIM, CDKN2A
16b 7234510.3VIM, MUC1, KRT20, KRT7
17periodate4510.3MUC1, MUC5AC
18s 1004510.3VIM, MUC1
19deoxyribonucleic acid4510.3ACPP, CDKN2A, AMACR
20dexamethasone45 50 29 1113.3MUC2, AMACR, CDKN2A, MUC5AC
21n-acetylglucosamine4510.3CHST4, MUC5AC, KRT7, CHST5
22dmso4510.3MUC1, MUC5AC, MUC2, VIM
235fluorouracil4510.2MUC2, TP53, CDKN2A, MUC1, MUC5AC
24formaldehyde45 2411.2KRT7, MUC1, KRT20, VIM
25guanidine hydrochloride4510.2MUC1, MUC5AC, ACPP
26actinomycin d4510.2TP53, CDKN2A, MUC2, MUC1, VIM
27retinoid4510.2KRT7, KRT4, TP53, MUC5AC, VIM
285-aza-2deoxycytidine4510.2VIM, MUC2, CDKN2A, KRT7, TP53, CDX2
29agar4510.2CDKN2A, MUC1, VIM, ACPP
30azathioprine45 50 2 1113.1MUC2, VIM, CDKN2A
31methotrexate45 50 1112.1VIM, MUC2, MUC5AC, MUC1, CDKN2A, KRT7
32cholesterol45 29 11 2413.0AMACR, MUC2, MUC5AC, MUC1, ACPP, CDKN2A
33sb 20358045 6011.0MUC5AC, MUC2, VIM, TP53
34cysteine4510.0MUC2, MUC1, CDX2, AMACR, MUC5AC, CDKN2A
35vegf459.9ACPP, VIM, TP53, KRT20, KRT7, CDKN2A
36oligonucleotide459.9CDX2, VIM, ACPP, AMACR, MUC2, MUC5AC
37testosterone45 60 11 2412.8CDKN2A, MUC1, AMACR, VIM, KRT20, ACPP
38retinoic acid45 2410.7CDKN2A, KRT4, KRT7, MUC5AC, AMACR, MUC2
39hematoxylin459.7MUC1, VIM, AMACR, MUC2, MUC5AC, CDKN2A
40vitamin d459.7ACPP, VIM, AMACR, CDX2
41glucose459.6AMACR, MUC5AC, KRT7, CDKN2A, MUC2, MUC1
42paraffin459.5ACPP, KRT7, CDX2, CDKN2A, MUC1, MUC5AC
43progesterone45 60 29 11 2413.3VIM, KRT20, AMACR, KRT4, MUC1, CDX2

GO Terms for genes affiliated with Mucinous Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.1MUC1, MUC5AC, MUC2
2intrinsic to Golgi membraneGO:0312289.9CHST5, CHST4
3intermediate filamentGO:0058829.8KRT20, KRT7, KRT4, VIM

Biological processes related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein sulfationGO:00647710.3CHST5, CHST4
2replicative senescenceGO:09039910.3CDKN2A, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP53, MUC1
4O-glycan processingGO:01626610.2MUC1, MUC5AC, MUC2
5intermediate filament organizationGO:04510910.2VIM, KRT20
6sulfur compound metabolic processGO:00679010.1CHST5, CHST4
7N-acetylglucosamine metabolic processGO:0060449.9CHST5, CHST4

Molecular functions related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:09737110.1CDKN2A, TP53
2p53 bindingGO:00203910.1TP53, CDKN2A, MUC1
3sulfotransferase activityGO:00814610.0CHST5, CHST4, GAL3ST2
4N-acetylglucosamine 6-O-sulfotransferase activityGO:0015179.9CHST4, CHST5

Products for genes affiliated with Mucinous Adenocarcinoma

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Sources for Mucinous Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet