MCID: MCN001
MIFTS: 56

Mucinous Adenocarcinoma malady

Cancer diseases category

Summaries for Mucinous Adenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which produce mucin.

MalaCards: Mucinous Adenocarcinoma, also known as mucin-producing adenocarcinoma, is related to adenocarcinoma and prostatitis. An important gene associated with Mucinous Adenocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeleton remodeling Keratin filaments. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include colon, prostate and pancreas, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:63 Mucinous carcinoma is a type of cancer that arises from epithelial cells; these line certain internal... more...

Aliases & Classifications for Mucinous Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mucinous adenocarcinoma 8 10
mucin-producing adenocarcinoma 8 60
pseudomyxoma peritonei with unknown primary site 8
mucin-secreting adenocarcinoma 8
mucin-secreting carcinoma 8
adenocarcinoma, mucinous 60
mucous carcinoma 8


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Disease Ontology8 DOID:3030
NCIt39 C26712
SNOMED-CT56 900006, 72495009
MeSH34 D002288

Related Diseases for Mucinous Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.9MUC5AC, MUC1, CDKN2A, CDX2, KRT4, KRT7
2prostatitis31.1ACPP
3colon adenocarcinoma31.0MUC5AC, MUC2, KRT20
4ovarian mucinous adenocarcinoma31.0SLC45A3
5bladder adenocarcinoma31.0CDX2, SLC45A3
6pseudomyxoma peritonei30.9MUC2, MUC5AC, CDX2, KRT7, KRT20
7signet ring cell adenocarcinoma30.8MUC2, KRT7, KRT20
8papillary adenocarcinoma30.8MUC1, MUC2
9lung adenocarcinoma30.7AMACR, MUC5AC, MUC1, CDKN2A, CDX2, KRT7
10gastric adenocarcinoma30.7MUC2, CDX2, KRT7, KRT20
11adenoma30.6AMACR, MUC2, TP53, ACPP, KRT20, KRT7
12neuroendocrine carcinoma30.4MUC1, CDX2, KRT7, KRT20
13adenocarcinoma in situ30.3CDKN2A
14ulcerative colitis30.2TP53
15cystadenocarcinoma30.2MUC2, MUC5AC, MUC1
16mucinous cystadenocarcinoma30.2MUC1, KRT7, KRT20
17papillary carcinoma30.2KRT20, KRT7, MUC1, MUC2, AMACR
18cervical adenocarcinoma30.2MUC5AC, CDKN2A, CDX2, KRT7, KRT20
19ovarian cancer30.2TP53, KRT7, CDKN2A, MUC1, AMACR
20colorectal cancer30.2AMACR, MUC2, MUC5AC, MUC1, CDKN2A, CDX2
21cystadenoma29.9KRT7
22sertoli cell tumor29.9MUC1, VIM
23sertoli-leydig cell tumor29.9MUC1, KRT7
24nephrogenic adenoma29.9AMACR, UPK3A, KRT7
25gallbladder cancer29.9MUC2, MUC5AC, CDX2, KRT7
26adenoid cystic carcinoma29.9VIM, MUC1, KRT7, KRT20
27transitional cell carcinoma29.9UPK3A, KRT7, KRT20, TP53
28prostate disease29.9AMACR, ACPP
29bladder carcinoma29.9UPK3A, MUC2, CDKN2A, KRT20, TP53
30endometrial carcinoma29.9MUC2, MUC5AC, CDKN2A, KRT7, KRT20, TP53
31colon cancer29.9AMACR, MUC2, CDX2, KRT20, TP53
32stomach cancer29.9AMACR, MUC2, MUC5AC, CDKN2A, CDX2, KRT20
33prostate adenocarcinoma10.8
34colon mucinous adenocarcinoma10.7
35appendix adenocarcinoma10.7
36ovary adenocarcinoma10.7
37renal pelvis adenocarcinoma10.7
38mucinous stomach adenocarcinoma10.5
39rectum mucinous adenocarcinoma10.5
40pancreas adenocarcinoma10.5
41endometrial mucinous adenocarcinoma10.5
42rectum adenocarcinoma10.4
43cystic teratoma10.4
44mature teratoma10.4
45endocervicitis10.4
46peritonitis10.4
47crohn's disease10.3
48bile duct mucinous adenocarcinoma10.3
49fallopian tube mucinous adenocarcinoma10.3
50ureter adenocarcinoma10.3

Graphical network of the top 20 diseases related to Mucinous Adenocarcinoma:



Diseases related to mucinous adenocarcinoma

Clinical Features for Mucinous Adenocarcinoma

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Drugs & Therapeutics for Mucinous Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Mucinous Adenocarcinoma

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Genetic Tests for Mucinous Adenocarcinoma

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Anatomical Context for Mucinous Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Mucinous Adenocarcinoma:

32
Colon, Prostate, Pancreas, Ovary, Skin, Lung, Appendix, Cervix, Breast, Salivary gland, Thyroid, Kidney, Thymus, Lymph node, Liver, Eye, Uterus, T cells, Small intestine, Testis, B cells, Tongue, Bronchial epithelium, Placenta, Bone, Heart, Trachea, Brain

Animal Models for Mucinous Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mucinous Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CDX2, MUC5AC, MUC2, NEK8, UPK3A, AMACR
2MP:00053819.3TP53, MUC2, MUC5AC, MUC1, CDKN2A, CDX2

Publications for Mucinous Adenocarcinoma

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50PubMed
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Articles related to Mucinous Adenocarcinoma:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Overall survival is improved in mucinous adenocarcinoma of the colon. (24425620)
2014
2
The "drunken honeycomb" feature of pulmonary mucinous adenocarcinoma: a diagnostic pitfall of bronchial brushing cytology. (21563323)
2013
3
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
4
KRAS mutation positive mucinous adenocarcinoma originating in mature ovarian teratoma: Case report and review of literature. (24422958)
2013
5
Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation. (24119562)
2013
6
Unusual isolated perineal recurrence in mucinous adenocarcinoma of the rectum after abdominoperineal resection: usefulness of dual-time-point FDG PET in evaluating mucinous tumors. (22955074)
2012
7
Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature. (23216975)
2012
8
Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma, and strumal carcinoid: a case report and literature review. (23029627)
2012
9
Clinics in diagnostic imaging (143). Perianal mucinous adenocarcinoma arising from chronic fistula-in-ano. (23268160)
2012
10
Coexistence of appendix mucinous cystadenoma, tubulovillous adenoma of the colon and adenocarcinoma of the colon. (22691834)
2012
11
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. (22569454)
2012
12
Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma. (22448644)
2012
13
Primary appendiceal mucinous adenocarcinoma. (22468066)
2011
14
Peritoneal melanosis associated with mucinous cystadenoma of the ovary and adenocarcinoma of the colon. (20173496)
2010
15
Para-neorectal mucinous adenocarcinoma following childhood pull-through procedure for imperforate anus. (19207703)
2010
16
Primary mucinous adenocarcinoma of the ileum. (20480843)
2010
17
Primary mucinous eccrine adenocarcinoma of the skin in a 69-year-old man. (20405690)
2010
18
Primary mucinous adenocarcinoma in a defunctionalized urinary bladder: a case report. (20062735)
2009
19
Primary mucinous adenocarcinoma of renal pelvis with carcinoembryonic antigen production. (18291507)
2008
20
Cystic lesion mimicking intraductal papillary mucinous tumor arising in heterotopic pancreas of the stomach and synchronous intraductal papillary mucinous adenocarcinoma of the pancreas. (18387995)
2008
21
Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report. (18822701)
2008
22
Chronic hidradenitis suppurativa and perianal mucinous adenocarcinoma. A case report. (17393769)
2007
23
Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix. (17460448)
2007
24
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia. (17906614)
2007
25
Mucinous adenocarcinoma of the rectum with breast and ocular metastases. (16644510)
2006
26
Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin. (16463270)
2006
27
Mucinous adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary--case report. (16800267)
2006
28
Pathology quiz case 1. Adenocarcinoma with features of mucinous adenocarcinoma (MAC) and cystadenocarcinoma (CAC). (16365230)
2005
29
Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung. (15151204)
2004
30
An ovarian mucinous adenocarcinoma arising from mature cystic teratoma associated with respiratory type tissue: a case report. (15656343)
2004
31
Synchronous mucinous adenocarcinoma of the endometrium and mucinous cystadenoma of bilateral ovaries presenting during fertility therapy. (14764048)
2004
32
Purification and characterization of a human pancreatic adenocarcinoma mucin. (11754731)
2002
33
Mucinous adenocarcinoma originating in localized type adenomyomatosis of the gallbladder. (11780399)
2001
34
Mucinous adenocarcinoma arising in chronic perianal fistulas. (11468456)
2001
35
Primary mucinous adenocarcinoma of the appendix: a rare entity in the differential diagnosis of ovarian cancer. (11147719)
2000
36
Intrasellar adenoid cystic carcinoma and papillary mucinous adenocarcinoma: two previously undescribed primary neoplasms at this site. (10359849)
1999
37
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. (9448015)
1998
38
Cytotoxic agents active against mucinous adenocarcinoma of the ovary. (9458301)
1998
39
Mucinous adenocarcinoma of the male urethra. (8961497)
1996
40
Mucinous adenocarcinoma of the endometrium with intestinal differentiation: a case report. (8522315)
1995
41
Mucinous adenocarcinoma metastatic to the iris, ciliary body, and choroid. (2165801)
1990
42
Prostate mucinous adenocarcinoma with signet ring cell. (1697435)
1990
43
Mucinous adenocarcinoma of the prostate gland. (2409826)
1985
44
Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathologic study of four cases. (6309685)
1983
45
Mucinous adenocarcinoma of prostate. (6249723)
1980
46
Calcified mucinous adenocarcinoma of the stomach. (210658)
1978
47
Calcifying mucinous adenocarcinoma of the gallbladder. (4350100)
1973
48
Giant retroperitoneal mucocele simulating pseudomyxoma peritonei and mucinous adenocarcinoma. (4300125)
1968
49
Mucinous adenocarcinoma of the urinary tract. (4290108)
1966
50
Mucinous adenocarcinoma of the bladder. (20279574)
1947

Genetic Variations for Mucinous Adenocarcinoma

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Expression for genes affiliated with Mucinous Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Mucinous Adenocarcinoma.

Pathways for genes affiliated with Mucinous Adenocarcinoma

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53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1MUC2, MUC5AC, MUC1
210.1KRT7, KRT4, VIM
39.9TP53, SLC45A3, CDKN2A, VIM

Compounds for genes affiliated with Mucinous Adenocarcinoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1butyrate4410.8CDX2
2estrogen4410.7ACPP
3sialic acid4410.7KRT7
4carbohydrates4410.5MUC2, MUC5AC
5reticulin4410.5VIM, KRT7, MUC1
6temozolomide44 1111.5VIM, TP53, CDKN2A
7eosin4410.4MUC1, VIM
8crcs4410.4TP53, CDKN2A, MUC1, MUC2
9streptavidin4410.4KRT7, KRT20, AMACR
10acnu4410.4TP53, CDKN2A
11biotin44 11 2412.4VIM, AMACR, CDKN2A, MUC1
12roscovitine4410.4TP53, VIM, CDKN2A
13mucicarmine4410.4VIM, KRT20, MUC1, KRT7
14cytarabine44 49 1112.4CDKN2A, VIM, MUC1, TP53
15adriamycin4410.3TP53, MUC1, VIM, CDKN2A
16b 7234410.3VIM, MUC1, KRT20, KRT7
17periodate4410.3MUC1, MUC5AC
18s 1004410.3VIM, MUC1
19deoxyribonucleic acid4410.3ACPP, CDKN2A, AMACR
20dexamethasone44 49 28 1113.3MUC2, AMACR, CDKN2A, MUC5AC
21n-acetylglucosamine4410.3CHST4, MUC5AC, KRT7, CHST5
22dmso4410.3MUC1, MUC5AC, MUC2, VIM
235fluorouracil4410.2MUC2, TP53, CDKN2A, MUC1, MUC5AC
24formaldehyde44 2411.2KRT7, MUC1, KRT20, VIM
25guanidine hydrochloride4410.2MUC1, MUC5AC, ACPP
26actinomycin d4410.2TP53, CDKN2A, MUC2, MUC1, VIM
27retinoid4410.2KRT7, KRT4, TP53, MUC5AC, VIM
285-aza-2deoxycytidine4410.2VIM, MUC2, CDKN2A, KRT7, TP53, CDX2
29agar4410.2CDKN2A, MUC1, VIM, ACPP
30azathioprine44 49 2 1113.1MUC2, VIM, CDKN2A
31methotrexate44 49 1112.1VIM, MUC2, MUC5AC, MUC1, CDKN2A, KRT7
32cholesterol44 28 11 2413.0AMACR, MUC2, MUC5AC, MUC1, ACPP, CDKN2A
33sb 20358044 5911.0MUC5AC, MUC2, VIM, TP53
34cysteine4410.0MUC2, MUC1, CDX2, AMACR, MUC5AC, CDKN2A
35vegf449.9ACPP, VIM, TP53, KRT20, KRT7, CDKN2A
36oligonucleotide449.9CDX2, VIM, ACPP, AMACR, MUC2, MUC5AC
37testosterone44 59 11 2412.8CDKN2A, MUC1, AMACR, VIM, KRT20, ACPP
38retinoic acid44 2410.7CDKN2A, KRT4, KRT7, MUC5AC, AMACR, MUC2
39hematoxylin449.7MUC1, VIM, AMACR, MUC2, MUC5AC, CDKN2A
40vitamin d449.7ACPP, VIM, AMACR, CDX2
41glucose449.6AMACR, MUC5AC, KRT7, CDKN2A, MUC2, MUC1
42paraffin449.5ACPP, KRT7, CDX2, CDKN2A, MUC1, MUC5AC
43progesterone44 59 28 11 2413.3VIM, KRT20, AMACR, KRT4, MUC1, CDX2

GO Terms for genes affiliated with Mucinous Adenocarcinoma

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16Gene Ontology
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Cellular components related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.1MUC1, MUC5AC, MUC2
2intrinsic to Golgi membraneGO:0312289.9CHST5, CHST4
3intermediate filamentGO:0058829.8KRT20, KRT7, KRT4, VIM

Biological processes related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein sulfationGO:00647710.3CHST5, CHST4
2replicative senescenceGO:09039910.3CDKN2A, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP53, MUC1
4O-glycan processingGO:01626610.2MUC1, MUC5AC, MUC2
5intermediate filament organizationGO:04510910.2VIM, KRT20
6sulfur compound metabolic processGO:00679010.1CHST5, CHST4
7N-acetylglucosamine metabolic processGO:0060449.9CHST5, CHST4

Molecular functions related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:09737110.1CDKN2A, TP53
2p53 bindingGO:00203910.1TP53, CDKN2A, MUC1
3sulfotransferase activityGO:00814610.0CHST5, CHST4, GAL3ST2
4N-acetylglucosamine 6-O-sulfotransferase activityGO:0015179.9CHST4, CHST5

Products for genes affiliated with Mucinous Adenocarcinoma

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Sources for Mucinous Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet