MCID: MCN001
MIFTS: 56

Mucinous Adenocarcinoma malady

Cancer diseases category

Summaries for Mucinous Adenocarcinoma

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which produce mucin.

MalaCards: Mucinous Adenocarcinoma, also known as mucin-producing adenocarcinoma, is related to adenocarcinoma and prostatitis. An important gene associated with Mucinous Adenocarcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are O-linked glycosylation of mucins and Cytoskeleton remodeling Keratin filaments. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include colon, prostate and pancreas, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Wikipedia:63 Mucinous carcinoma is a type of cancer that arises from epithelial cells; these line certain internal... more...

Aliases & Classifications for Mucinous Adenocarcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mucinous adenocarcinoma 8 10
mucin-producing adenocarcinoma 8 60
pseudomyxoma peritonei with unknown primary site 8
mucin-secreting adenocarcinoma 8
mucin-secreting carcinoma 8
adenocarcinoma, mucinous 60
mucous carcinoma 8


External Ids:

Disease Ontology8 DOID:3030
NCIt39 C26712
SNOMED-CT56 900006, 72495009
MeSH34 D002288

Related Diseases for Mucinous Adenocarcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.9MUC5AC, MUC1, CDKN2A, CDX2, KRT4, KRT7
2prostatitis31.1ACPP
3colon adenocarcinoma31.0MUC5AC, MUC2, KRT20
4ovarian mucinous adenocarcinoma31.0SLC45A3
5bladder adenocarcinoma31.0CDX2, SLC45A3
6pseudomyxoma peritonei30.9MUC2, MUC5AC, CDX2, KRT7, KRT20
7signet ring cell adenocarcinoma30.8MUC2, KRT7, KRT20
8papillary adenocarcinoma30.8MUC1, MUC2
9lung adenocarcinoma30.7AMACR, MUC5AC, MUC1, CDKN2A, CDX2, KRT7
10gastric adenocarcinoma30.7MUC2, CDX2, KRT7, KRT20
11adenoma30.6AMACR, MUC2, TP53, ACPP, KRT20, KRT7
12neuroendocrine carcinoma30.4MUC1, CDX2, KRT7, KRT20
13adenocarcinoma in situ30.3CDKN2A
14ulcerative colitis30.2TP53
15cystadenocarcinoma30.2MUC2, MUC5AC, MUC1
16mucinous cystadenocarcinoma30.2MUC1, KRT7, KRT20
17papillary carcinoma30.2KRT20, KRT7, MUC1, MUC2, AMACR
18cervical adenocarcinoma30.2MUC5AC, CDKN2A, CDX2, KRT7, KRT20
19ovarian cancer30.2TP53, KRT7, CDKN2A, MUC1, AMACR
20colorectal cancer30.2AMACR, MUC2, MUC5AC, MUC1, CDKN2A, CDX2
21cystadenoma29.9KRT7
22sertoli cell tumor29.9MUC1, VIM
23sertoli-leydig cell tumor29.9MUC1, KRT7
24nephrogenic adenoma29.9AMACR, UPK3A, KRT7
25gallbladder cancer29.9MUC2, MUC5AC, CDX2, KRT7
26adenoid cystic carcinoma29.9VIM, MUC1, KRT7, KRT20
27transitional cell carcinoma29.9UPK3A, KRT7, KRT20, TP53
28prostate disease29.9AMACR, ACPP
29bladder carcinoma29.9UPK3A, MUC2, CDKN2A, KRT20, TP53
30endometrial carcinoma29.9MUC2, MUC5AC, CDKN2A, KRT7, KRT20, TP53
31colon cancer29.9AMACR, MUC2, CDX2, KRT20, TP53
32stomach cancer29.9AMACR, MUC2, MUC5AC, CDKN2A, CDX2, KRT20
33prostate adenocarcinoma10.8
34colon mucinous adenocarcinoma10.7
35appendix adenocarcinoma10.7
36ovary adenocarcinoma10.7
37renal pelvis adenocarcinoma10.7
38mucinous stomach adenocarcinoma10.5
39rectum mucinous adenocarcinoma10.5
40pancreas adenocarcinoma10.5
41endometrial mucinous adenocarcinoma10.5
42rectum adenocarcinoma10.4
43cystic teratoma10.4
44mature teratoma10.4
45endocervicitis10.4
46peritonitis10.4
47crohn's disease10.3
48bile duct mucinous adenocarcinoma10.3
49fallopian tube mucinous adenocarcinoma10.3
50ureter adenocarcinoma10.3

Graphical network of the top 20 diseases related to Mucinous Adenocarcinoma:



Diseases related to mucinous adenocarcinoma

Clinical Features for Mucinous Adenocarcinoma

About this section

Drugs & Therapeutics for Mucinous Adenocarcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mucinous Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Mucinous Adenocarcinoma

Search NIH Clinical Center for Mucinous Adenocarcinoma

Search CenterWatch for Mucinous Adenocarcinoma

Genetic Tests for Mucinous Adenocarcinoma

About this section

Anatomical Context for Mucinous Adenocarcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Mucinous Adenocarcinoma:

32
Colon, Prostate, Pancreas, Ovary, Lung, Skin, Appendix, Cervix, Breast, Salivary gland, Kidney, Thyroid, Thymus, Lymph node, Liver, Small intestine, Uterus, T cells, Testis, Eye, Tongue, Trachea, B cells, Bone, Placenta, Brain, Heart, Bronchial epithelium

Animal Models for Mucinous Adenocarcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Mucinous Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8CDX2, MUC5AC, MUC2, NEK8, UPK3A, AMACR
2MP:00053819.3TP53, MUC2, MUC5AC, MUC1, CDKN2A, CDX2

Publications for Mucinous Adenocarcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Mucinous Adenocarcinoma:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Minor salivary gland mucinous adenocarcinoma of buccal mucosa - case report and review of the literature. (24375048)
2013
2
Pulmonary artery embolization for refractory hypoxemia caused by invasive mucinous adenocarcinoma. (23328554)
2013
3
Rare case of primary mucinous adenocarcinoma of vagina. (24125996)
2013
4
Label-free imaging characteristics of colonic mucinous adenocarcinoma using multiphoton microscopy. (23168617)
2013
5
Metastasis to ileostomy of mucinous adenocarcinoma of rectum. (24392566)
2013
6
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma. (22173559)
2012
7
Signet ring cell carcinoma as a potential confounding factor in the analysis of outcomes with colorectal mucinous adenocarcinoma. (22959467)
2012
8
Mucinous adenocarcinoma of the endometrium: case series and review of the literature. (22569105)
2012
9
Laparoscopic treatment of adult sigmoidorectal intussusception caused by a mucinous adenocarcinoma of the sigmoid colon: a case report. (21431097)
2011
10
Urachal adenocarcinoma metastatic to the ovaries resembling primary ovarian mucinous carcinoma: a case report with the immunohistochemical study. (21228934)
2010
11
Interesting image. Utility of FDG metabolism to differentiate synchronous metastatic liver lesions from synchronous colon cancer: nonmucinous versus mucinous adenocarcinoma. (20026977)
2010
12
Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. (19037659)
2009
13
Extensive perineal and pelvic defects reconstructed simultaneously using bilateral pedicled gracilis and rectus abdominis muscle flaps after en-bloc excision of locally invasive perineal mucinous adenocarcinoma 1. (19863433)
2009
14
Mucinous adenocarcinoma of the thymus: a case report. (18670316)
2008
15
Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. (18301950)
2008
16
Usefulness of heavily T2-weighted magnetic resonance imaging in the diagnosis of alveolar lung metastases from pancreas mucinous adenocarcinoma. (18347520)
2008
17
Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma. (18849918)
2008
18
Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms. (18753969)
2008
19
Primary mucinous adenocarcinoma in an ileostomy with adjacent skin invasion: a late complication of surgery for ulcerative colitis. (19418266)
2008
20
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. (17349581)
2007
21
Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from a single institution. (17357864)
2007
22
Urachal mucinous adenocarcinoma: a case report. (18067216)
2007
23
Synchronous mucinous adenocarcinoma of the rectosigmoid seeding onto a pre-existing anal fistula. (16961916)
2006
24
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
25
Case of mucinous adenocarcinoma with porcelain gallbladder. (12859733)
2003
26
Cytokeratin 7/20 and mucin expression patterns in oesophageal, cardia and distal gastric adenocarcinomas. (14636271)
2003
27
Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. (14654543)
2003
28
Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. (12010891)
2002
29
Mucinous adenocarcinoma arising in a neovagina using the sigmoid colon thirty years after operation: a case report. (11344485)
2001
30
Mucinous adenocarcinoma of renal pelvis and villous adenoma of bladder after a caecal augmentation of bladder. (10075375)
1999
31
MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrence. (10215233)
1999
32
Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. (9677464)
1998
33
Mucinous adenocarcinoma of the renal pelvis in natives of India. (9096276)
1997
34
Prognostic significance of preimmunotherapy serum CA27.29 (MUC-1) mucin level after active specific immunotherapy of metastatic adenocarcinoma patients. (9101416)
1997
35
Mucinous adenocarcinoma of the renal pelvis--a case report. (9354016)
1997
36
Mucinous adenocarcinoma of the ovary as a cause of ascites in a goat. (7751247)
1995
37
Mucin expression in colon adenocarcinoma cell lines. (8654714)
1995
38
Mucinous adenocarcinoma at the ileocecal valve mimicking Crohn's disease. (7924755)
1994
39
Primary mucinous adenocarcinoma of renal pelvis in solitary pelvic kidney. (8382888)
1993
40
Anorectal mucinous adenocarcinoma associated with latent perianal Paget's disease. (2154090)
1990
41
Ultrasound case of the day. Poorly differentiated mucinous adenocarcinoma of the sigmoid colon, metastatic to the tunica vaginalis of the left hemiscrotum. (2543040)
1989
42
Mucinous adenocarcinoma of the prostate presenting as a retrovesical cyst. Case report. (2847308)
1988
43
Mucinous adenocarcinoma of the colon in a child. (3009625)
1985
44
Mucinous adenocarcinoma of the renal pelvis. (6090148)
1984
45
Mucinous adenocarcinoma and clear cell adenocarcinoma arising in separate ovaries. (6293404)
1983
46
Primary mucinous adenocarcinoma of the urinary bladder. (4354773)
1973
47
Mucinous adenocarcinoma of the urachus: review of the literature and report of a case. (13212890)
1954
48
Mucinous adenocarcinoma of the urachus. (13040720)
1953
49
Mucinous adenocarcinoma of the pelvis of the kidney. (18899418)
1948
50
Mucinous adenocarcinoma of the pelvis of the kidney. (21009420)
1946

Genetic Variations for Mucinous Adenocarcinoma

About this section

Expression for genes affiliated with Mucinous Adenocarcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Mucinous Adenocarcinoma.

Pathways for genes affiliated with Mucinous Adenocarcinoma

About this section
Sources:
53Reactome, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1MUC2, MUC5AC, MUC1
210.1KRT7, KRT4, VIM
39.9TP53, SLC45A3, CDKN2A, VIM

Compounds for genes affiliated with Mucinous Adenocarcinoma

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1butyrate4410.8CDX2
2estrogen4410.7ACPP
3sialic acid4410.7KRT7
4carbohydrates4410.5MUC2, MUC5AC
5reticulin4410.5VIM, MUC1, KRT7
6temozolomide44 1111.5TP53, CDKN2A, VIM
7eosin4410.4MUC1, VIM
8crcs4410.4TP53, CDKN2A, MUC1, MUC2
9streptavidin4410.4AMACR, KRT7, KRT20
10acnu4410.4TP53, CDKN2A
11biotin44 11 2412.4VIM, AMACR, MUC1, CDKN2A
12roscovitine4410.4VIM, CDKN2A, TP53
13s 1004410.4MUC1, VIM
14mucicarmine4410.4VIM, MUC1, KRT7, KRT20
15cytarabine44 49 1112.4VIM, MUC1, CDKN2A, TP53
16adriamycin4410.3TP53, CDKN2A, MUC1, VIM
17b 7234410.3VIM, MUC1, KRT7, KRT20
18deoxyribonucleic acid4410.3ACPP, CDKN2A, AMACR
19periodate4410.3MUC1, MUC5AC
20dexamethasone44 49 28 1113.3AMACR, MUC2, MUC5AC, CDKN2A
21n-acetylglucosamine4410.3CHST4, CHST5, MUC5AC, KRT7
22dmso4410.3MUC1, MUC5AC, MUC2, VIM
235fluorouracil4410.2TP53, CDKN2A, MUC1, MUC5AC, MUC2
24formaldehyde44 2411.2VIM, MUC1, KRT7, KRT20
25guanidine hydrochloride4410.2MUC5AC, MUC1, ACPP
26actinomycin d4410.2VIM, MUC2, MUC1, CDKN2A, TP53
27retinoid4410.2VIM, MUC5AC, KRT4, KRT7, TP53
285-aza-2deoxycytidine4410.2VIM, MUC2, CDKN2A, CDX2, KRT7, TP53
29agar4410.2VIM, MUC1, CDKN2A, ACPP
30azathioprine44 49 2 1113.1CDKN2A, MUC2, VIM
31methotrexate44 49 1112.1VIM, MUC2, MUC5AC, MUC1, CDKN2A, KRT7
32cholesterol44 28 11 2413.0AMACR, MUC2, MUC5AC, MUC1, CDKN2A, ACPP
33sb 20358044 5911.0VIM, MUC2, MUC5AC, TP53
34cysteine4410.0VIM, AMACR, MUC2, MUC5AC, MUC1, CDKN2A
35vegf449.9VIM, MUC1, CDKN2A, KRT7, KRT20, ACPP
36oligonucleotide449.9VIM, AMACR, MUC2, MUC5AC, CDKN2A, CDX2
37testosterone44 59 11 2412.8VIM, AMACR, MUC5AC, MUC1, CDKN2A, KRT7
38retinoic acid44 2410.7VIM, AMACR, MUC2, MUC5AC, MUC1, CDKN2A
39hematoxylin449.7ACPP, VIM, AMACR, MUC2, MUC5AC, MUC1
40vitamin d449.7VIM, AMACR, CDX2, ACPP
41glucose449.6AMACR, MUC2, MUC5AC, MUC1, CDKN2A, KRT7
42paraffin449.5VIM, AMACR, MUC2, MUC5AC, MUC1, CDKN2A
43progesterone44 59 28 11 2413.3MUC1, MUC5AC, MUC2, AMACR, VIM, CDKN2A

GO Terms for genes affiliated with Mucinous Adenocarcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.1MUC1, MUC5AC, MUC2
2intrinsic to Golgi membraneGO:0312289.9CHST5, CHST4
3intermediate filamentGO:0058829.8KRT20, KRT7, KRT4, VIM

Biological processes related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein sulfationGO:00647710.3CHST5, CHST4
2replicative senescenceGO:09039910.3CDKN2A, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP53, MUC1
4O-glycan processingGO:01626610.2MUC1, MUC5AC, MUC2
5intermediate filament organizationGO:04510910.2VIM, KRT20
6sulfur compound metabolic processGO:00679010.1CHST5, CHST4
7N-acetylglucosamine metabolic processGO:0060449.9CHST5, CHST4

Molecular functions related to Mucinous Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:09737110.1CDKN2A, TP53
2p53 bindingGO:00203910.1TP53, CDKN2A, MUC1
3sulfotransferase activityGO:00814610.0CHST5, CHST4, GAL3ST2
4N-acetylglucosamine 6-O-sulfotransferase activityGO:0015179.9CHST4, CHST5

Products for genes affiliated with Mucinous Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mucinous Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet