MCID: MCC002
MIFTS: 42

Mucocutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Mucocutaneous Leishmaniasis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards: Mucocutaneous Leishmaniasis, also known as mucocutaneous leishmaniasis, american, is related to leishmaniasis and cutaneous leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Calcium signaling in the CD4+ TCR pathway and Downstream signaling in naive CD8+ T cells. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

mucocutaneous leishmaniasis 8 10 60
mucocutaneous leishmaniasis, american 8
american mucocutaneous leishmaniasis 8
new world cutaneous leishmaniasis 8
cutaneous leishmaniasis, american 8
american cutaneous leishmaniasis 8
mucocutaneous leishmaniasis, 8


External Ids:

Disease Ontology8 DOID:9155
ICD9CM27 085.4, 085.5
MeSH34 D007897
NCIt39 C34769
ICD1025 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Clinical Features for Mucocutaneous Leishmaniasis

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Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mucocutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

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Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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32MalaCards
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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

32
Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

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Publications for Mucocutaneous Leishmaniasis

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50PubMed
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Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
2
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
3
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? (22434112)
2013
4
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. (23148292)
2013
5
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
6
Diffuse mucocutaneous leishmaniasis. (22479746)
2011
7
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)
2011
8
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. (21311023)
2011
9
Treatment strategies for mucocutaneous leishmaniasis. (20606970)
2010
10
Mucocutaneous leishmaniasis treated with liposomal amphotericin B. (18368279)
2008
11
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007
12
Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis. (17641726)
2007
13
Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony. (17119754)
2006
14
Eco-epidemiological survey of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in Ribeira Valley River, ParanA! State, Brazil. (15652328)
2005
15
Mucocutaneous leishmaniasis presenting as facial cellulitis. (16175986)
2005
16
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
17
Mucocutaneous leishmaniasis in a US citizen. (14600692)
2003
18
Use of itraconazole in the treatment of mucocutaneous leishmaniasis: a pilot study. (11179919)
2000
19
Mucocutaneous leishmaniasis associated with HIV infection treated successfully with liposomal amphotericin B (AmBisome) (10933674)
2000
20
Atypical mucocutaneous leishmaniasis caused by Leishmania braziliensis in an acquired immunodeficiency syndrome patient: T-cell responses and remission of lesions associated with antigen immunotherapy. (10446016)
1999
21
PCR-ELISA for diagnosis of mucocutaneous leishmaniasis. (10379813)
1999
22
Efficacy of sodium stibogluconate alone and in combination with allopurinol for treatment of mucocutaneous leishmaniasis. (9314461)
1997
23
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
24
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
25
American mucocutaneous leishmaniasis. (7805299)
1994
26
Immunohistochemical analysis of the mucosal lesion in mucocutaneous leishmaniasis. (9235205)
1994
27
American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)
1992
28
Successful treatment of an antimony-resistant American mucocutaneous leishmaniasis: a case report. (1626977)
1992
29
Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)
1991
30
Parasitological diagnosis of mucocutaneous leishmaniasis due to Leishmania b. braziliensis in Bolivia. (1845007)
1991
31
Mucocutaneous leishmaniasis due to Leishmania (Leishmania) infantum: biochemical characterization. (2267965)
1990
32
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
33
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
34
Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)
1988
35
Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. (2437815)
1987
36
Evaluation of T-cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis. (2957642)
1987
37
Failure to detect circulating Leishmania in mucocutaneous leishmaniasis due to Leishmania braziliensis braziliensis. (3787695)
1986
38
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
39
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
40
Renal tubular dysfunction in patients with mucocutaneous leishmaniasis treated with pentavalent antimonials. (6136717)
1983
41
On distinguishing the female of Psychodopygus wellcomei, a vector of mucocutaneous leishmaniasis, from other squamiventris series females. I. Characterization of Ps. squamiventris squamiventris and Ps. s. maripaensis stat. nov. (Diptera: psychodidae). (7092371)
1982
42
The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)
1981
43
Parasitologic and immunologic diagnosis of American (mucocutaneous) leishmaniasis. (7030439)
1981
44
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
45
Apparent Glucantime failure in five patients with mucocutaneous leishmaniasis. (6997505)
1980
46
Treatment of mucocutaneous leishmaniasis. (449896)
1979
47
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
48
Use of amphotericin B in mucocutaneous leishmaniasis. (933229)
1976
49
Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)
1974
50
American mucocutaneous Leishmaniasis successfully treated with 2-hydroxystilbamidine. (12996541)
1952

Genetic Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 53Reactome, 51QIAGEN
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Compounds for genes affiliated with Mucocutaneous Leishmaniasis

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.0TNF, IFNG
2vesnarinone4410.0TNF, IFNG
3taurine chloramine4410.0TNF, IFNG
4gold sodium thiomalate4410.0TNF, IFNG
5natalizumab44 1111.0IFNG, TNF
6adalimumab44 49 1112.0TNF, IFNG
7il-124410.0TNF, IFNG
8staurosporin4410.0IFNG, TNF
9indoleamine4410.0IFNG, TNF
10imiquimod44 28 59 1113.0TNF, IFNG
11polymyxin b4410.0TNF, IFNG
12okt3449.9IFNG, TNF
13gm-csf44 2810.9TNF, IFNG
14triptolide449.9TNF, IFNG
15budesonide44 49 1111.9IFNG, TNF
16parthenolide44 210.9IFNG, TNF
17fluticasone propionate44 49 59 1112.9TNF, IFNG
182,5-oligoadenylate449.9TNF, IFNG
19polyinosinic-polycytidylic acid449.9TNF, IFNG
20etanercept44 49 1111.9IFNG, TNF
21poly(i-c)449.9TNF, IFNG
22il 10449.8TNF, IFNG
23l-nmma449.8IFNG, TNF
24infliximab44 49 1111.8IFNG, TNF
25glucosamine44 11 2411.8TNF, IFNG
26tarc449.7TNF, IFNG
27Inosinic Acid11 2410.7ENTPD3, ENTPD8
28inosine triphosphate44 2410.7ENTPD3, ENTPD8
29ivig449.7TNF, IFNG
30ccl344 2810.6IFNG, TNF
3115-deoxy-delta-12,14-prostaglandin j2449.6TNF, IFNG
32melphalan44 1110.5TNF, IFNG
33neopterin449.3TNF, IFNG

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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16Gene Ontology
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Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.8IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8humoral immune responseGO:0069599.6TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
10positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoside-triphosphatase activityGO:0171119.3ENTPD8, ENTPD3
2nucleoside-diphosphatase activityGO:0171109.0ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

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Sources for Mucocutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet