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MCID: MCC002
MIFTS: 48

Mucocutaneous Leishmaniasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mucocutaneous Leishmaniasis

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MalaCards integrated aliases for Mucocutaneous Leishmaniasis:

Name: Mucocutaneous Leishmaniasis 12 14 69
American Cutaneous Leishmaniasis 12 69
Mucocutaneous Leishmaniasis, American 12
American Mucocutaneous Leishmaniasis 12
Cutaneous Leishmaniasis, American 12
New World Cutaneous Leishmaniasis 12
Mucocutaneous Leishmaniasis, 12
Leishmaniasis, Mucocutaneous 41

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9155
ICD10 32 B55.2
ICD9CM 34 085.5
MeSH 41 D007897
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Summaries for Mucocutaneous Leishmaniasis

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Disease Ontology : 12 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary : Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to lepromatous leprosy and acquired immunodeficiency syndrome. An important gene associated with Mucocutaneous Leishmaniasis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Akt Signaling and T cell receptor signaling pathway. The drugs meglumine antimoniate and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and skin, and related phenotypes are cardiovascular system and behavior/neurological

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Related Diseases for Mucocutaneous Leishmaniasis

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Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 lepromatous leprosy 30.2 IL10 TNF
2 acquired immunodeficiency syndrome 29.8 CCR5 IL10 TNF
3 chagas disease 29.8 CCR5 IL10 TNF
4 wegener granulomatosis 29.8 CCR5 IL10 TNF
5 kala-azar 1 11.3
6 leishmaniasis 10.9
7 punctate inner choroidopathy 10.4 IL10 TNF
8 tropical endomyocardial fibrosis 10.4 IL10 TNF
9 microscopic polyangiitis 10.4 IL10 TNF
10 multifocal choroiditis 10.4 IL10 TNF
11 tungiasis 10.4 IL10 TNF
12 endomyocardial fibrosis 10.4 IL10 TNF
13 choroiditis 10.4 IL10 TNF
14 trichuriasis 10.4 IL10 TNF
15 clonorchiasis 10.4 IL10 TNF
16 trachoma 10.4 IL10 TNF
17 listeriosis 10.4 IL10 TNF
18 poliomyelitis 10.4 IL10 TNF
19 transverse myelitis 10.4 IL10 TNF
20 primary systemic mycosis 10.4 IL10 TNF
21 intermediate uveitis 10.4 IL10 TNF
22 multidrug-resistant tuberculosis 10.4 IL10 TNF
23 coccidiosis 10.4 IL10 TNF
24 eales disease 10.4 IL10 TNF
25 hemorrhagic fever 10.4 IL10 TNF
26 aseptic meningitis 10.4 IL10 TNF
27 spotted fever 10.4 IL10 TNF
28 hematopoietic stem cell transplantation 10.4 IL10 TNF
29 panuveitis 10.4 IL10 TNF
30 scrub typhus 10.4 IL10 TNF
31 cytomegalovirus infection 10.4 IL10 TNF
32 plasmodium vivax malaria 10.4 IL10 TNF
33 q fever 10.4 IL10 TNF
34 viral encephalitis 10.4 IL10 TNF
35 aphthous stomatitis 10.4 IL10 TNF
36 epstein-barr virus-associated gastric carcinoma 10.4 IL10 TNF
37 japanese encephalitis 10.4 TLR3 TNF
38 churg-strauss syndrome 10.4 IL10 TNF
39 severe hemophilia a 10.4 IL10 TNF
40 hemorrhagic fever with renal syndrome 10.3 IL10 TNF
41 hepatitis e 10.3 TLR3 TNF
42 acute graft versus host disease 10.3 IL10 TNF
43 opportunistic mycosis 10.3 IL10 TNF
44 complex regional pain syndrome 10.3 IL10 TNF
45 bacterial vaginosis 10.3 IL10 TNF
46 spondylarthropathy 10.3 LTA TNF
47 streptococcal toxic-shock syndrome 10.3 LTA TNF
48 null-cell leukemia 10.3 LTA TNF
49 idiopathic neutropenia 10.3 IL10 TNF
50 paracoccidioidomycosis 10.3 IL10 TNF

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to Mucocutaneous Leishmaniasis
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Symptoms & Phenotypes for Mucocutaneous Leishmaniasis

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MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 TLR3 IL10 TNF LTA CCR5 NID1
2 behavior/neurological MP:0005386 10 TLR3 IL10 LTA CCR5 NID1 SCYL1
3 hematopoietic system MP:0005397 9.95 TLR3 IL10 LTA CCR5 SCYL1 FLI1
4 immune system MP:0005387 9.91 TNF TLR3 IL10 LTA CCR5 FLI1
5 muscle MP:0005369 9.8 TLR3 IL10 TNF CCR5 NID1 SCYL1
6 liver/biliary system MP:0005370 9.72 TNF IL10 LTA CCR5 FLI1
7 nervous system MP:0003631 9.56 TLR3 IL10 TNF LTA CCR5 NID1
8 neoplasm MP:0002006 9.55 TLR3 IL10 TNF CCR5 FLI1
9 vision/eye MP:0005391 9.1 IL10 TNF LTA CCR5 NID1 SCYL1
Sources

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 meglumine antimoniate Phase 2, Phase 3
2 Anti-Infective Agents Phase 2, Phase 3,Phase 1
3 Antiprotozoal Agents Phase 2, Phase 3,Phase 1
4 Antiparasitic Agents Phase 2, Phase 3,Phase 1
5
Amphotericin B Approved, Investigational Phase 1, Phase 2 1397-89-3 5280965 14956
6
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
7
Miltefosine Approved, Investigational Phase 2,Phase 1 58066-85-6 3600
8
Coal tar Approved Phase 2 8007-45-2
9
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
10 Anthelmintics Phase 1, Phase 2
11 Antifungal Agents Phase 2,Phase 1
12 Antimony Sodium Gluconate Phase 1, Phase 2
13 Liposomal amphotericin B Phase 1, Phase 2
14 Vasodilator Agents Phase 2
15 Phosphodiesterase Inhibitors Phase 2
16 Platelet Aggregation Inhibitors Phase 2
17 Protective Agents Phase 2
18 Radiation-Protective Agents Phase 2
19 Antioxidants Phase 2
20 Vaccines Phase 1
21
Cortisone acetate Approved, Investigational 1950-04-4, 50-04-4 5745
22
Cortisone 53-06-5 222786
23 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Low Antimonial Dosage in American Mucosal Leishmaniasis Recruiting NCT01301937 Phase 2, Phase 3 Meglumine antimoniate
2 Miltefosine to Treat Mucocutaneous Leishmaniasis Completed NCT01050907 Phase 2 miltefosine
3 Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis Completed NCT01377974 Phase 2 Miltefosine;Standard Treatment Meglumine antimoniate
4 Miltefosine for Mucosal Leishmaniasis Completed NCT00373776 Phase 1, Phase 2 miltefosine 2.5 mg/kg/day for 28 days
5 Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis Completed NCT00373568 Phase 1, Phase 2 miltefosine: 2.5 mg/kg/day for 42 days
6 Use of Sodium Stibogluconate as a Treatment for Leishmaniasis Completed NCT00657618 Phase 1, Phase 2 Sodium Stibogluconate (SSG)
7 Sodium Stibogluconate Treatment of Leishmaniasis Completed NCT00662012 Phase 2 Sodium Stibogluconate (SSG)
8 Miltefosine to Treat Cutaneous Leishmaniasis in Bolivia Completed NCT00233545 Phase 2 miltefosine;antimony
9 The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil Recruiting NCT02530697 Phase 2 Meglumine antimoniate;Miltefosine;Pentoxifylline
10 Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis Completed NCT00111514 Phase 1
11 Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02429518 Miltefosine
12 Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02431429 Miltefosine
13 Cortisone and QTc-Interval Recruiting NCT03082339
14 Diagnosis and Treatment of Leishmanial Infections Recruiting NCT00344188
15 Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis Available NCT00508963 sodium stibogluconate (Pentostam)

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

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Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

38
T Cells, Testes, Skin, Monocytes
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Publications for Mucocutaneous Leishmaniasis

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Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 150)
# Title Authors Year
1
Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to<i>Leishmania braziliensis</i>. ( 29405108 )
2018
2
Deforming Mucocutaneous Leishmaniasis of the Nose. ( 28538073 )
2017
3
Cost-effectiveness of liposomal amphotericin B in hospitalised patients with mucocutaneous leishmaniasis. ( 29078022 )
2017
4
Mucocutaneous Leishmaniasis in Immunocompromised Patients: Report of 4 Cases in Spain. ( 29100620 )
2017
5
Synthetic peptides derived from ribosomal proteins of Leishmania spp. in mucocutaneous leishmaniasis: Diagnostic usefulness. ( 28758598 )
2017
6
Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient. ( 27890957 )
2016
7
Mucocutaneous leishmaniasis with marked facial disfigurement. ( 27643545 )
2016
8
Mucocutaneous leishmaniasis. ( 26994882 )
2016
9
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 25661291 )
2015
10
Mucocutaneous leishmaniasis caused by Leishmania infantum var Lombardi in an immunocompetent patient, Spain. ( 25559703 )
2015
11
Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. ( 26568336 )
2015
12
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. ( 26568335 )
2015
13
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 28349799 )
2015
14
Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. ( 25645330 )
2015
15
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25830540 )
2015
16
Polymerase chain reaction-miniexon: a promising diagnostic method for mucocutaneous leishmaniasis. ( 26452681 )
2015
17
Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. ( 25442251 )
2015
18
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25946238 )
2015
19
Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome. ( 26154873 )
2015
20
Mucocutaneous leishmaniasis of the nose: a case report. ( 26513953 )
2015
21
Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. ( 24126182 )
2014
22
Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area. ( 24923211 )
2014
23
Mucocutaneous leishmaniasis caused by Leishmania donovani infection in an Indian man. ( 25557311 )
2014
24
Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash. ( 25548691 )
2014
25
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. ( 24897964 )
2014
26
A case of mucocutaneous leishmaniasis diagnosed by serology. ( 25041360 )
2014
27
First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. ( 23669431 )
2013
28
Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. ( 24170665 )
2013
29
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? ( 22434112 )
2013
30
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. ( 23637917 )
2013
31
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. ( 23690792 )
2013
32
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. ( 23867693 )
2013
33
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. ( 23148292 )
2013
34
Mucocutaneous leishmaniasis in a patient treated with anti-TNF-I+ therapy. ( 22427411 )
2012
35
Primary lesion of mucocutaneous leishmaniasis simulating external otitis. ( 23108835 )
2012
36
Cutaneous and mucocutaneous leishmaniasis. ( 22632640 )
2012
37
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. ( 22819605 )
2012
38
Diffuse mucocutaneous leishmaniasis. ( 22479746 )
2011
39
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. ( 21739015 )
2011
40
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. ( 21311023 )
2011
41
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. ( 21460009 )
2011
42
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. ( 19836815 )
2010
43
A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. ( 20465699 )
2010
44
Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. ( 20375822 )
2010
45
Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. ( 20163267 )
2010
46
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. ( 20377337 )
2010
47
Treatment strategies for mucocutaneous leishmaniasis. ( 20606970 )
2010
48
The value of the otorhinolaryngologic exam in correct mucocutaneous leishmaniasis diagnosis. ( 19706900 )
2009
49
Interventions for American cutaneous and mucocutaneous leishmaniasis. ( 19370612 )
2009
50
Cutaneous and mucocutaneous leishmaniasis. ( 19889134 )
2009
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Variations for Mucocutaneous Leishmaniasis

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Expression for Mucocutaneous Leishmaniasis

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Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.
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Pathways for Mucocutaneous Leishmaniasis

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Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 60
Show member pathways
 13.04 CCR5 IL10 LTA TLR3 TNF
2
T cell receptor signaling pathway 36
Show member pathways
 12.14 CCR5 IL10 TNF
3
NF-kappaB Signaling 4
12.14 FLI1 IL10 TLR3 TNF
4
Toxoplasmosis 36
Show member pathways
 11.88 CCR5 IL10 TNF
5
Immune response IFN alpha/beta signaling pathway 21
Show member pathways
 11.75 IL10 LTA TNF
6
Innate Lymphoid Cell Differentiation Pathways 61
11.34 IL10 LTA TNF
7
IgA-Producing B Cells in the Intestine 61
11.15 IL10 LTA TNF
8
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
Show member pathways
 11.09 IL10 TNF
9
African trypanosomiasis 36
11.07 IL10 TNF
10
IL-10 Pathway 60
11.05 IL10 TNF
11
Cytokines and Inflammatory Response 1
10.95 IL10 TNF
12
IL27-mediated signaling events 1
Show member pathways
 10.94 IL10 LTA TLR3 TNF
13
OX40 Pathway 60
10.87 IL10 LTA
14
Interleukin-10 signaling 62
10.82 CCR5 IL10 TNF
15
G-protein signaling_RhoB regulation pathway 21
10.81 IL10 LTA TNF
Sources

GO Terms for Mucocutaneous Leishmaniasis

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Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 CCR5 IL10 LTA TNF
2 defense response to bacterium GO:0042742 9.77 IL10 TLR3 TNF
3 inflammatory response GO:0006954 9.76 CCR5 IL10 TLR3 TNF
4 defense response GO:0006952 9.69 CCR5 TLR3 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.67 CCR5 IL10 TNF
6 positive regulation of interferon-gamma production GO:0032729 9.62 LTA TNF
7 extrinsic apoptotic signaling pathway GO:0097191 9.61 TLR3 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.61 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.59 IL10 TNF
10 positive regulation of cytokine production GO:0001819 9.58 TLR3 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.58 TLR3 TNF
12 negative regulation of interleukin-6 production GO:0032715 9.57 IL10 TNF
13 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 TLR3 TNF
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
15 positive regulation of chemokine production GO:0032722 9.54 TLR3 TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL10 TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TLR3 TNF
18 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
19 necroptotic signaling pathway GO:0097527 9.37 TLR3 TNF
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
21 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 LTA TNF
22 receptor biosynthetic process GO:0032800 9.16 IL10 TNF
23 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
24 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 LTA TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF
2 cytokine activity GO:0005125 8.8 IL10 LTA TNF
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Sources for Mucocutaneous Leishmaniasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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