MCID: MCC002
MIFTS: 45

Mucocutaneous Leishmaniasis

Categories: Infectious diseases

Aliases & Classifications for Mucocutaneous Leishmaniasis

MalaCards integrated aliases for Mucocutaneous Leishmaniasis:

Name: Mucocutaneous Leishmaniasis 12 14 69
American Cutaneous Leishmaniasis 12 69
Mucocutaneous Leishmaniasis, American 12
American Mucocutaneous Leishmaniasis 12
Cutaneous Leishmaniasis, American 12
New World Cutaneous Leishmaniasis 12
Mucocutaneous Leishmaniasis, 12
Leishmaniasis, Mucocutaneous 42

Classifications:



External Ids:

Disease Ontology 12 DOID:9155
ICD10 33 B55.2
ICD9CM 35 085.5
MeSH 42 D007897
UMLS 69 C1328252

Summaries for Mucocutaneous Leishmaniasis

Disease Ontology : 12 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary : Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and pure autonomic failure. An important gene associated with Mucocutaneous Leishmaniasis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Anti-Infective Agents and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and skin, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Mucocutaneous Leishmaniasis

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
id Related Disease Score Top Affiliating Genes
1 leishmaniasis 10.8
2 pure autonomic failure 10.7 IL10 TNF
3 multiple familial trichoepithelioma 10.7 IL10 TNF
4 endosalpingiosis 10.7 IL10 TNF
5 ethmoid sinus adenocarcinoma 10.7 IL10 TNF
6 tarsal tunnel syndrome 10.7 IL10 TNF
7 plantar wart 10.7 IL10 TNF
8 chronic apical periodontitis 10.6 IL10 TNF
9 tricho onychic dysplasia 10.6 IL10 TNF
10 cyclosporiasis 10.6 IL10 TNF
11 urethra transitional cell carcinoma 10.6 IL10 TNF
12 hepadnavirus infection 10.6 IL10 TNF
13 senile reticular retinal degeneration 10.6 IL10 TNF
14 ulcerative colitis 10.6 IL10 TNF
15 psychologic dyspareunia 10.6 IL10 TNF
16 hemophagocytic lymphohistiocytosis 10.6 IL10 TNF
17 cryptococcosis 10.6 IL10 TNF
18 megaloblastic anemia 10.6 IL10 TNF
19 dysphagia 10.6 IL10 TNF
20 conduct disorder 10.6 IL10 TNF
21 angiodysplasia of intestine 10.6 TLR3 TNF
22 bartonellosis 10.5 IL10 TNF
23 ovarian mucinous adenofibroma 10.5 IL10 TNF
24 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.5 IL10 TNF
25 cutaneous fibrous histiocytoma 10.5 TLR3 TNF
26 glioblastoma multiforme 10.5 IL10 TNF
27 high pressure neurological syndrome 10.5 IL10 TNF
28 urethral intrinsic sphincter deficiency 10.5 IL4 TNF
29 eye accommodation disease 10.5 IL10 IL4
30 moderately severe hemophilia b 10.5 IL10 TNF
31 hypospadias 10.5 IL10 TNF
32 thelaziasis 10.5 IL10 IL4
33 deafness, autosomal recessive 22 10.5 IL10 IL4
34 lymphocytic colitis 10.5 IL4 TNF
35 cherry allergy 10.5 IL10 IL4
36 cow milk allergy 10.5 IL10 IL4
37 plummer's disease 10.5 IL10 TNF
38 centronuclear myopathy 5 10.4 IL10 IL4
39 residual stage corticosteroid-induced glaucoma 10.4 IL10 TNF
40 bardet-biedl syndrome 15 10.4 IL10 IL4
41 vascular dementia 10.4 IL10 IL4
42 spondylocostal dysostosis 4 10.4 LTA TNF
43 spirillary rat-bite fever 10.4 LTA TNF
44 toxoplasmosis 10.4 LTA TNF
45 acute vascular insufficiency of intestine 10.4 IL4 TNF
46 cauda equina syndrome 10.4 LTA TNF
47 kernicterus due to isoimmunization 10.4 LTA TNF
48 nut allergy 10.4 IL10 IL4
49 dentinogenesis imperfecta 10.4 IL10 TLR3 TNF
50 reardon wilson cavanagh syndrome 10.3 IL4 TNF

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to Mucocutaneous Leishmaniasis

Symptoms & Phenotypes for Mucocutaneous Leishmaniasis

MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CCR5 FLI1 IL10 LTA NID1 SCYL1
2 hematopoietic system MP:0005397 10.08 CCR5 FLI1 IL10 IL4 LTA SCYL1
3 behavior/neurological MP:0005386 10.07 CCR5 IL10 LTA NID1 SCYL1 TLR3
4 immune system MP:0005387 10.06 CCR5 FLI1 IL10 IL4 LTA SCYL1
5 mortality/aging MP:0010768 10.01 FLI1 IL10 IL4 LTA SCYL1 TLR3
6 endocrine/exocrine gland MP:0005379 9.97 FLI1 IL10 IL4 LTA TLR3 TNF
7 liver/biliary system MP:0005370 9.91 CCR5 FLI1 IL10 IL4 LTA TNF
8 muscle MP:0005369 9.91 CCR5 FLI1 IL10 NID1 SCYL1 TLR3
9 nervous system MP:0003631 9.91 IL10 IL4 LTA NID1 SCYL1 TLR3
10 neoplasm MP:0002006 9.72 CCR5 FLI1 IL10 TLR3 TNF
11 reproductive system MP:0005389 9.63 CCR5 IL10 IL4 SCYL1 TLR3 TNF
12 respiratory system MP:0005388 9.35 LTA TLR3 TNF IL10 IL4
13 vision/eye MP:0005391 9.17 CCR5 IL10 IL4 LTA NID1 SCYL1

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 2, Phase 3,Phase 1
2 Antiparasitic Agents Phase 2, Phase 3,Phase 1
3 Antiprotozoal Agents Phase 2, Phase 3,Phase 1
4 meglumine antimoniate Phase 2, Phase 3
5
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
6
Miltefosine Approved Phase 2,Phase 1 58066-85-6 3600
7
Coal tar Approved Phase 2 8007-45-2
8
Amphotericin B Approved, Investigational Phase 1, Phase 2 1397-89-3 14956 5280965
9
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
10 Antifungal Agents Phase 2,Phase 1
11 Anthelmintics Phase 1, Phase 2
12 Antimony Sodium Gluconate Phase 1, Phase 2
13 Liposomal amphotericin B Phase 1, Phase 2
14 Antioxidants Phase 2
15 Phosphodiesterase Inhibitors Phase 2
16 Platelet Aggregation Inhibitors Phase 2
17 Protective Agents Phase 2
18 Radiation-Protective Agents Phase 2
19 Vasodilator Agents Phase 2
20 Vaccines Phase 1
21
Cortisone acetate Approved 1950-04-4, 50-04-4 5745
22 Anti-Inflammatory Agents
23
Cortisone 53-06-5 222786

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Low Antimonial Dosage in American Mucosal Leishmaniasis Recruiting NCT01301937 Phase 2, Phase 3 Meglumine antimoniate
2 Miltefosine to Treat Mucocutaneous Leishmaniasis Completed NCT01050907 Phase 2 miltefosine
3 Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis Completed NCT01377974 Phase 2 Miltefosine;Standard Treatment Meglumine antimoniate
4 Miltefosine for Mucosal Leishmaniasis Completed NCT00373776 Phase 1, Phase 2 miltefosine 2.5 mg/kg/day for 28 days
5 Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis Completed NCT00373568 Phase 1, Phase 2 miltefosine: 2.5 mg/kg/day for 42 days
6 Use of Sodium Stibogluconate as a Treatment for Leishmaniasis Completed NCT00657618 Phase 1, Phase 2 Sodium Stibogluconate (SSG)
7 Sodium Stibogluconate Treatment of Leishmaniasis Completed NCT00662012 Phase 2 Sodium Stibogluconate (SSG)
8 Miltefosine to Treat Cutaneous Leishmaniasis in Bolivia Completed NCT00233545 Phase 2 miltefosine;antimony
9 The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil Recruiting NCT02530697 Phase 2 Meglumine antimoniate;Miltefosine;Pentoxifylline
10 Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis Completed NCT00111514 Phase 1
11 Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02429518 Miltefosine
12 Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02431429 Miltefosine
13 Diagnosis and Treatment of Leishmanial Infections Recruiting NCT00344188
14 Cortisone and QTc-Interval Recruiting NCT03082339
15 Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis Available NCT00508963 sodium stibogluconate (Pentostam)

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

39
T Cells, Testes, Skin, Monocytes

Publications for Mucocutaneous Leishmaniasis

Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 147)
id Title Authors Year
1
Deforming Mucocutaneous Leishmaniasis of the Nose. ( 28538073 )
2017
2
Synthetic peptides derived from ribosomal proteins of Leishmania spp. in mucocutaneous leishmaniasis: Diagnostic usefulness. ( 28758598 )
2017
3
Mucocutaneous leishmaniasis. ( 26994882 )
2016
4
Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient. ( 27890957 )
2016
5
Mucocutaneous leishmaniasis with marked facial disfigurement. ( 27643545 )
2016
6
Mucocutaneous leishmaniasis caused by Leishmania infantum var Lombardi in an immunocompetent patient, Spain. ( 25559703 )
2015
7
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 28349799 )
2015
8
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25830540 )
2015
9
Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. ( 25442251 )
2015
10
Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. ( 26568336 )
2015
11
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25946238 )
2015
12
Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. ( 25645330 )
2015
13
Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome. ( 26154873 )
2015
14
Polymerase chain reaction-miniexon: a promising diagnostic method for mucocutaneous leishmaniasis. ( 26452681 )
2015
15
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 25661291 )
2015
16
Mucocutaneous leishmaniasis of the nose: a case report. ( 26513953 )
2015
17
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. ( 26568335 )
2015
18
Mucocutaneous leishmaniasis caused by Leishmania donovani infection in an Indian man. ( 25557311 )
2014
19
Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash. ( 25548691 )
2014
20
A case of mucocutaneous leishmaniasis diagnosed by serology. ( 25041360 )
2014
21
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. ( 24897964 )
2014
22
Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. ( 24126182 )
2014
23
Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area. ( 24923211 )
2014
24
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? ( 22434112 )
2013
25
First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. ( 23669431 )
2013
26
Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. ( 24170665 )
2013
27
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. ( 23148292 )
2013
28
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. ( 23690792 )
2013
29
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. ( 23867693 )
2013
30
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. ( 23637917 )
2013
31
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. ( 22819605 )
2012
32
Primary lesion of mucocutaneous leishmaniasis simulating external otitis. ( 23108835 )
2012
33
Mucocutaneous leishmaniasis in a patient treated with anti-TNF-I+ therapy. ( 22427411 )
2012
34
Cutaneous and mucocutaneous leishmaniasis. ( 22632640 )
2012
35
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. ( 21460009 )
2011
36
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. ( 21739015 )
2011
37
Diffuse mucocutaneous leishmaniasis. ( 22479746 )
2011
38
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. ( 21311023 )
2011
39
Treatment strategies for mucocutaneous leishmaniasis. ( 20606970 )
2010
40
A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. ( 20465699 )
2010
41
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. ( 19836815 )
2010
42
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. ( 20377337 )
2010
43
Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. ( 20375822 )
2010
44
Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. ( 20163267 )
2010
45
Interventions for American cutaneous and mucocutaneous leishmaniasis. ( 19370612 )
2009
46
Cutaneous and mucocutaneous leishmaniasis. ( 19889134 )
2009
47
The value of the otorhinolaryngologic exam in correct mucocutaneous leishmaniasis diagnosis. ( 19706900 )
2009
48
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. ( 19356780 )
2009
49
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? ( 19090806 )
2008
50
Mucocutaneous leishmaniasis treated with liposomal amphotericin B. ( 18368279 )
2008

Variations for Mucocutaneous Leishmaniasis

Expression for Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for Mucocutaneous Leishmaniasis

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CCR5 IL10 IL4 LTA TLR3 TNF
2
Show member pathways
13.09 CCR5 IL10 IL4 LTA TNF
3
Show member pathways
13.04 CCR5 IL10 IL4 LTA TNF
4
Show member pathways
12.61 IL10 IL4 LTA TNF
5
Show member pathways
12.55 IL4 LTA TLR3 TNF
6
Show member pathways
12.22 CCR5 IL10 IL4 TNF
7 12.22 FLI1 IL10 IL4 TLR3 TNF
8
Show member pathways
12.05 CCR5 IL10 IL4 TNF
9
Show member pathways
11.88 IL10 IL4 LTA TNF
10 11.79 IL10 IL4 TNF
11 11.77 IL10 IL4 TNF
12
Show member pathways
11.59 IL10 LTA TLR3 TNF
13 11.47 IL10 IL4 LTA
14 11.36 IL10 IL4 LTA TNF
15
Show member pathways
11.21 IL10 TNF
16 11.15 IL10 TNF
17 11.14 IL10 TNF
18 11.1 IL4 TNF
19 11.1 IL10 IL4 LTA TNF
20 11.09 IL10 IL4 TNF
21 11 IL10 IL4 LTA
22 10.99 IL10 IL4 LTA TNF
23 10.61 CCR5 IL10 IL4 TNF

GO Terms for Mucocutaneous Leishmaniasis

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CCR5 IL10 TLR3 TNF
2 defense response to bacterium GO:0042742 9.83 IL10 TLR3 TNF
3 positive regulation of transcription, DNA-templated GO:0045893 9.82 IL10 IL4 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.78 IL4 TLR3 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.74 CCR5 IL10 TNF
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.71 IL10 IL4 TNF
7 extrinsic apoptotic signaling pathway GO:0097191 9.67 TLR3 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.66 IL10 TNF
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 IL10 IL4
10 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
11 positive regulation of cytokine production GO:0001819 9.65 TLR3 TNF
12 immune response GO:0006955 9.65 CCR5 IL10 IL4 LTA TNF
13 positive regulation of interleukin-8 production GO:0032757 9.64 TLR3 TNF
14 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TNF
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.63 IL10 TNF
16 negative regulation of osteoclast differentiation GO:0045671 9.62 IL4 TLR3
17 defense response to protozoan GO:0042832 9.62 IL10 IL4
18 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 TLR3 TNF
19 negative regulation of nitric oxide biosynthetic process GO:0045019 9.59 IL10 IL4
20 positive regulation of chemokine production GO:0032722 9.58 TLR3 TNF
21 microglial cell activation GO:0001774 9.58 IL4 TLR3
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
23 endothelial cell apoptotic process GO:0072577 9.52 IL10 TNF
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL10 IL4
25 necroptotic signaling pathway GO:0097527 9.49 TLR3 TNF
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 IL10 TNF
27 type 2 immune response GO:0042092 9.46 IL10 IL4
28 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.43 LTA TNF
29 regulation of isotype switching GO:0045191 9.4 IL10 IL4
30 positive regulation of mononuclear cell migration GO:0071677 9.37 IL4 TNF
31 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
32 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
33 negative regulation of growth of symbiont in host GO:0044130 9.13 IL10 LTA TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 8.8 IL4 TLR3 TNF
35 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10 FLI1 IL10 IL4 TLR3 TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF
2 cytokine activity GO:0005125 8.92 IL10 IL4 LTA TNF

Sources for Mucocutaneous Leishmaniasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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