Mucocutaneous Leishmaniasis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Mucocutaneous Leishmaniasis

Sources:
⁸Disease Ontology, ³²MalaCards
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Disease Ontology:⁸ A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards: Mucocutaneous Leishmaniasis, also known as mucocutaneous leishmaniasis, american, is related to leishmaniasis and cutaneous leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Calcium signaling in the CD4+ TCR pathway and Downstream signaling in naive CD8+ T cells. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS, ²⁷ICD9CM, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt, ²⁵ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases

ICD10: ²⁵

Certain infectious and parasitic diseases

Protozoal diseases

Leishmaniasis

Mucocutaneous leishmaniasis

Aliases & Descriptions:

mucocutaneous leishmaniasis ⁸ ¹⁰ ⁶⁰

mucocutaneous leishmaniasis, american ⁸

american mucocutaneous leishmaniasis ⁸

new world cutaneous leishmaniasis ⁸

cutaneous leishmaniasis, american ⁸

american cutaneous leishmaniasis ⁸

mucocutaneous leishmaniasis, ⁸

External Ids:

Disease Ontology⁸ DOID:9155

ICD9CM²⁷ 085.4, 085.5

MeSH³⁴ D007897

SNOMED-CT⁵⁶ 186810001, 39625001, 266122008 403135004, 186809006, 77327004, more

NCIt³⁹ C34769

ICD10²⁵ B55.2

UMLS⁶⁰ C1328252

Related Diseases for Mucocutaneous Leishmaniasis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 28)

id	Related Disease	Score	Top Affiliating Genes
1	leishmaniasis	31.7	IFNG
2	cutaneous leishmaniasis	31.3	PKD2L1
3	visceral leishmaniasis	30.1	PKD2L1
4	granulomatous dermatitis	10.3
5	erysipeloid	10.3
6	dermatitis	10.3
7	leprosy	10.3
8	pulmonary tuberculosis	10.2
9	tuberculosis	10.2
10	yaws	10.2
11	cellulitis	10.1
12	chagas disease	10.1
13	pharyngitis	10.1
14	tuberculoid leprosy	10.1
15	borderline leprosy	10.1
16	lepromatous leprosy	10.1
17	chronic dacryocystitis	10.1
18	acquired immunodeficiency syndrome	10.1
19	dacryocystitis	10.1
20	interstitial keratitis	10.1
21	keratitis	10.1
22	laryngitis	10.1
23	aids dementia complex	10.0	TNF
24	acute graft versus host disease	10.0	TNF, IFNG
25	cerebral malaria	10.0	IFNG, TNF
26	toxic shock syndrome	10.0	TNF, IFNG
27	pulmonary sarcoidosis	10.0	TNF, IFNG
28	graft versus host disease	10.0	TNF, IFNG

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:

Clinical Features for Mucocutaneous Leishmaniasis

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mucocutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Search CenterWatch for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

Sources:
³²MalaCards
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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

³²

Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

Publications for Mucocutaneous Leishmaniasis

Sources:
⁵⁰PubMed
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Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 125)

id	Title	Authors	Year
1	Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)	Reveiz L.... Yadon Z.E.	2013
2	Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)	Ruoti M.... Krentel A.	2013
3	Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? (22434112)	Dassoni F.... Morrone A.	2013
4	Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. (23148292)	Farias L.H.... Silva E.O.	2013
5	Cutaneous and mucocutaneous leishmaniasis. (22632640)	Goto H.... Lauletta Lindoso J.A.	2012
6	Diffuse mucocutaneous leishmaniasis. (22479746)	Mathur A.... Butoli J.	2011
7	Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)	Veland N.... Boggild A.K.	2011
8	Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. (21311023)	Ives A.... Masina S.	2011
9	Treatment strategies for mucocutaneous leishmaniasis. (20606970)	Palumbo E.	2010
10	Mucocutaneous leishmaniasis treated with liposomal amphotericin B. (18368279)	Lambertucci J.R.... Silva L.C.	2008
11	Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)	Llanos-Cuentas A.... Bryceson A.	2007
12	Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis. (17641726)	Cuna W.R.... RodrA-guez C.	2007
13	Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony. (17119754)	de Oliveira-Neto M.P.... Mattos M.d.a. .S.	2006
14	Eco-epidemiological survey of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in Ribeira Valley River, ParanA! State, Brazil. (15652328)	de Castro E.A.... Soccol V.T.	2005
15	Mucocutaneous leishmaniasis presenting as facial cellulitis. (16175986)	Clayton R.... Grabczynska S.	2005
16	Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)	Motta A.C.... Foss N.T.	2003
17	Mucocutaneous leishmaniasis in a US citizen. (14600692)	Costa J.W.... Maguire J.H.	2003
18	Use of itraconazole in the treatment of mucocutaneous leishmaniasis: a pilot study. (11179919)	Amato V.S.... Neto V.A.	2000
19	Mucocutaneous leishmaniasis associated with HIV infection treated successfully with liposomal amphotericin B (AmBisome) (10933674)	Amato V.S.... Neto V.A.	2000
20	Atypical mucocutaneous leishmaniasis caused by Leishmania braziliensis in an acquired immunodeficiency syndrome patient: T-cell responses and remission of lesions associated with antigen immunotherapy. (10446016)	Da-Cruz A.M.... Coutinho S.G.	1999
21	PCR-ELISA for diagnosis of mucocutaneous leishmaniasis. (10379813)	PiA+ero J.... Valladares B.	1999
22	Efficacy of sodium stibogluconate alone and in combination with allopurinol for treatment of mucocutaneous leishmaniasis. (9314461)	Llanos-Cuentas A.... Marr J.	1997
23	Cutaneous and mucocutaneous leishmaniasis. (8620680)	Samady J.A.... Schwartz R.A.	1996
24	Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)	Falcoff E.... BernabA^ J.G.	1994
25	American mucocutaneous leishmaniasis. (7805299)	Goihman-Yahr M.	1994
26	Immunohistochemical analysis of the mucosal lesion in mucocutaneous leishmaniasis. (9235205)	Esterre P.... Grimaud J.A.	1994
27	American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)	Escobar M.A.... Palma G.I.	1992
28	Successful treatment of an antimony-resistant American mucocutaneous leishmaniasis: a case report. (1626977)	Bottasso O.... Falcoff E.	1992
29	Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)	Bittencourt A.L.... Barral A.	1991
30	Parasitological diagnosis of mucocutaneous leishmaniasis due to Leishmania b. braziliensis in Bolivia. (1845007)	Dimier-David L.... Dedet J.P.	1991
31	Mucocutaneous leishmaniasis due to Leishmania (Leishmania) infantum: biochemical characterization. (2267965)	Alvar J.... Cabrer B.	1990
32	Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)	Ridley D.S.... Marsden P.D.	1989
33	Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)	Marzochi M.C.... Barbosa-Santos E.G.	1988
34	Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)	ConceiAsALo-Silva F.... Coutinho S.G.	1988
35	Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. (2437815)	Weigle K.A.... D'Alessandro A.	1987
36	Evaluation of T-cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis. (2957642)	Barral A.... Johnson W.D.	1987
37	Failure to detect circulating Leishmania in mucocutaneous leishmaniasis due to Leishmania braziliensis braziliensis. (3787695)	Cuba-Cuba C.A.... Marsden P.D.	1986
38	Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)	Saravia N.G.... D'Alessandro A.	1985
39	A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)	Urjel R.... Orellana H.	1983
40	Renal tubular dysfunction in patients with mucocutaneous leishmaniasis treated with pentavalent antimonials. (6136717)	Veiga J.P.... Marsden P.D.	1983
41	On distinguishing the female of Psychodopygus wellcomei, a vector of mucocutaneous leishmaniasis, from other squamiventris series females. I. Characterization of Ps. squamiventris squamiventris and Ps. s. maripaensis stat. nov. (Diptera: psychodidae). (7092371)	Ready P.D.... Pajot F.X.	1982
42	The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)	Marinkelle C.J.	1981
43	Parasitologic and immunologic diagnosis of American (mucocutaneous) leishmaniasis. (7030439)	Cuba Cuba C.A.... Patzlaff L.	1981
44	A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)	Ridley D.S.... Barreto A.C.	1980
45	Apparent Glucantime failure in five patients with mucocutaneous leishmaniasis. (6997505)	Rocha R.A.... Marsden P.D.	1980
46	Treatment of mucocutaneous leishmaniasis. (449896)	Rodbard D.	1979
47	Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)	Belehu A.... Touw-Langendijk E.	1978
48	Use of amphotericin B in mucocutaneous leishmaniasis. (933229)	Crofts M.A.	1976
49	Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)	GuimarALes M.C.... Camargo M.E.	1974
50	American mucocutaneous Leishmaniasis successfully treated with 2-hydroxystilbamidine. (12996541)	SNAPPER I.	1952

Genes related to Mucocutaneous Leishmaniasis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Mucocutaneous Leishmaniasis:

id	Symbol	Description	Score	Implication
1	IFNG	interferon, gamma	21.67	GeneCards inferred : Publications, Disorders (show sections)
2	TNF	tumor necrosis factor	18.34	GeneCards inferred : Publications, Disorders (show sections)
3	ENTPD3	ectonucleoside triphosphate diphosphohydrolase 3	15.00	GeneCards inferred : Disorders (show sections)
4	ENTPD8	ectonucleoside triphosphate diphosphohydrolase 8	11.67	GeneCards inferred : Disorders (show sections)
5	PKD2L1	polycystic kidney disease 2-like 1	8.34	GeneCards inferred : Disorders (show sections)
6	RPL14	ribosomal protein L14	5.00	GeneCards inferred : Disorders (show sections)

Products for genes related to Mucocutaneous Leishmaniasis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	6	6	6
2	LSBio	-	-	6

Genetic Variations for Mucocutaneous Leishmaniasis

Expression for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
³⁷NCBI BioSystems Database, ⁵²R&D Systems, ¹²EMD Millipore, ²⁹KEGG, ⁵³Reactome, ⁵¹QIAGEN
See all sources

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 15)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Calcium signaling in the CD4+ TCR pathway³⁷ Hide members Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷	9.6	TNF, IFNG
2	Downstream signaling in naive CD8+ T cells³⁷	9.6	TNF, IFNG
3	TGF Beta Signaling Pathway³⁷	9.6	IFNG, TNF
4	IL27-mediated signaling events³⁷ Hide members Th1 Differentiation⁵²	9.6	IFNG, TNF
5	Immune response Bacterial infections in normal airways	9.6	TNF, IFNG
6	Transcription Role of VDR in regulation of genes involved in osteoporosis Hide members Transcription Role of VDR in regulation of genes involved in osteoporosis¹²	9.6	TNF, IFNG
7	Malaria²⁹	9.6	TNF, IFNG
8	RIP-mediated NFkB activation via ZBP1⁵³ Hide members Cellular Transformation by HTLV1⁵¹ Activation of NF-KappaB by PKR⁵¹	9.6	IFNG, TNF
9	Immune response MIF-mediated glucocorticoid regulation¹²	9.6	IFNG, TNF
10	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵² Hide members IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵²	9.6	TNF, IFNG
11	Cytokines and Inflammatory Response³⁷	9.6	IFNG, TNF
12	Cytokine Network⁵¹	9.6	TNF, IFNG
13	MSP-RON Signaling⁵¹	9.6	TNF, IFNG
14	African trypanosomiasis²⁹	9.6	TNF, IFNG
15	Epstein-Barr virus infection²⁹	8.9	ENTPD8, ENTPD3, IFNG

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁴⁹PharmGKB, ²⁸IUPHAR, ⁵⁹Tocris Bioscience, ²BitterDB, ²⁴HMDB
See all sources

Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 33)

id	Compound	Score	Top Affiliating Genes
1	interferon gamma⁴⁴	10.0	TNF, IFNG
2	vesnarinone⁴⁴	10.0	TNF, IFNG
3	taurine chloramine⁴⁴	10.0	TNF, IFNG
4	gold sodium thiomalate⁴⁴	10.0	TNF, IFNG
5	natalizumab⁴⁴ ¹¹	11.0	IFNG, TNF
6	adalimumab⁴⁴ ⁴⁹ ¹¹	12.0	TNF, IFNG
7	il-12⁴⁴	10.0	TNF, IFNG
8	staurosporin⁴⁴	10.0	IFNG, TNF
9	indoleamine⁴⁴	10.0	IFNG, TNF
10	imiquimod⁴⁴ ²⁸ ⁵⁹ ¹¹	13.0	TNF, IFNG
11	polymyxin b⁴⁴	10.0	TNF, IFNG
12	okt3⁴⁴	9.9	IFNG, TNF
13	gm-csf⁴⁴ ²⁸	10.9	TNF, IFNG
14	triptolide⁴⁴	9.9	TNF, IFNG
15	budesonide⁴⁴ ⁴⁹ ¹¹	11.9	IFNG, TNF
16	parthenolide⁴⁴ ²	10.9	IFNG, TNF
17	fluticasone propionate⁴⁴ ⁴⁹ ⁵⁹ ¹¹	12.9	TNF, IFNG
18	2,5-oligoadenylate⁴⁴	9.9	TNF, IFNG
19	polyinosinic-polycytidylic acid⁴⁴	9.9	TNF, IFNG
20	etanercept⁴⁴ ⁴⁹ ¹¹	11.9	IFNG, TNF
21	poly(i-c)⁴⁴	9.9	TNF, IFNG
22	il 10⁴⁴	9.8	TNF, IFNG
23	l-nmma⁴⁴	9.8	IFNG, TNF
24	infliximab⁴⁴ ⁴⁹ ¹¹	11.8	IFNG, TNF
25	glucosamine⁴⁴ ¹¹ ²⁴	11.8	TNF, IFNG
26	tarc⁴⁴	9.7	TNF, IFNG
27	Inosinic Acid¹¹ ²⁴	10.7	ENTPD3, ENTPD8
28	inosine triphosphate⁴⁴ ²⁴	10.7	ENTPD3, ENTPD8
29	ivig⁴⁴	9.7	TNF, IFNG
30	ccl3⁴⁴ ²⁸	10.6	IFNG, TNF
31	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	9.6	TNF, IFNG
32	melphalan⁴⁴ ¹¹	10.5	TNF, IFNG
33	neopterin⁴⁴	9.3	TNF, IFNG

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of vitamin D biosynthetic process	GO:060557	9.8	TNF, IFNG
2	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.8	TNF, IFNG
3	positive regulation of chemokine biosynthetic process	GO:045080	9.8	IFNG, TNF
4	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.8	TNF, IFNG
5	negative regulation of growth of symbiont in host	GO:044130	9.7	TNF, IFNG
6	positive regulation of osteoclast differentiation	GO:045672	9.7	IFNG, TNF
7	protein import into nucleus, translocation	GO:000060	9.6	TNF, IFNG
8	humoral immune response	GO:006959	9.6	TNF, IFNG
9	extrinsic apoptotic signaling pathway	GO:097191	9.5	TNF, IFNG
10	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TNF, IFNG