MCID: MCC002
MIFTS: 46

Mucocutaneous Leishmaniasis malady

Category: Infectious diseases

Aliases & Classifications for Mucocutaneous Leishmaniasis

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Aliases & Descriptions for Mucocutaneous Leishmaniasis:

Name: Mucocutaneous Leishmaniasis 11 13 68
American Cutaneous Leishmaniasis 11 68
Mucocutaneous Leishmaniasis, American 11
American Mucocutaneous Leishmaniasis 11
 
Cutaneous Leishmaniasis, American 11
New World Cutaneous Leishmaniasis 11
Mucocutaneous Leishmaniasis, 11
Leishmaniasis, Mucocutaneous 39

Classifications:



External Ids:

Disease Ontology11 DOID:9155
ICD1030 B55.2
ICD9CM32 085.5
MeSH39 D007897

Summaries for Mucocutaneous Leishmaniasis

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Disease Ontology:11 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and pyridoxal 5'-phosphate-dependent epilepsy. An important gene associated with Mucocutaneous Leishmaniasis is TNF (Tumor Necrosis Factor), and among its related pathways are IL-10 Pathway and African trypanosomiasis. Affiliated tissues include t cells, testes and skin, and related mouse phenotypes are muscle and respiratory system.

Related Diseases for Mucocutaneous Leishmaniasis

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Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis10.8
2pyridoxal 5'-phosphate-dependent epilepsy10.3IL10, TNF
3multiple vertebral anomalies unusual facies10.3IL10, TNF
4endosalpingiosis10.3IL10, TNF
5severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.3IL10, TNF
6tarsal tunnel syndrome10.3IL10, TNF
7chronic apical periodontitis10.2IL10, TNF
8plantar wart10.2IL10, TNF
9spondylometaphyseal dysplasia east-african type10.2LTA, TNF
10thymic neuroendocrine carcinoma10.2LTA, TNF
11prostate calculus10.2CD4, TNF
12inflammatory breast carcinoma10.2IL10, LTA
13parkinson disease 1110.2IL10, TNF
14dermatitis herpetiformis10.2CD4, TNF
15drug dependence10.2LTA, TNF
16kernicterus due to isoimmunization10.2LTA, TNF
17facial paralysis10.2CD4, IL10
18autosomal dominant deafness-onychodystrophy syndrome10.2IL4, TNF
19asymptomatic neurosyphilis10.2IL10, IL4
20ciliary discoordination, due to random ciliary orientation10.2CD4, IL10
21ceroid lipofuscinosis, neuronal, 310.2IL10, IL4
22depressed scar10.2IL10, TLR3, TNF
23tungiasis10.2IL10, IL4
24urethral intrinsic sphincter deficiency10.1IL4, TNF
25congenital heart defects, hamartomas of tongue, and polysyndactyly10.1IL10, IL4
26goat milk allergy10.1IL10, IL4
27uveitis10.1CD4, TNF
28indian plum allergy10.1IL10, IL4
29centronuclear myopathy 510.1IL10, IL4
30abdominal tuberculosis10.1CD4, IL10
31clostridium difficile colitis10.1IL4, TNF
32kala-azar 110.1
33steatitis10.1CD8A, TNF
34hypotrichosis 410.1IL4, TNF
35idiopathic hypertrophic pachymeningitis10.1IL10, LTA, TNF
36transient tic disorder10.1CD4, IL10, TNF
37hypoparathyroidism-retardation-dysmorphism syndrome10.1CD4, IL10, TNF
38sarcomatoid transitional cell carcinoma10.1CD4, IL10, TNF
39rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.1CD4, IL10, TNF
40primary ciliary dyskinesia10.1IL10, LTA, TNF
41cryptococcosis10.1CD4, IL10, TNF
42hyperoxaluria, primary, type ii10.1CD8A, TNF
43anterior foramen magnum meningioma10.1CD4, IL10, TNF
44anus leiomyosarcoma10.1CD4, IL10, TNF
45detrusor sphincter dyssynergia10.1CD4, IL10, TNF
46eczematous dermatitis of eyelid10.1IL10, TLR3, TNF
47anterior dislocation of lens10.1CD4, IL4
48lens-induced iridocyclitis10.1CD4, IL4
49paralytic poliomyelitis10.1CD8A, TLR3
50cauda equina syndrome10.1LTA, TNF

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Symptoms & Phenotypes for Mucocutaneous Leishmaniasis

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MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.4IL10, NID1, SCYL1, TLR3, TNF
2MP:00053889.0IL10, IL4, LTA, TLR3, TNF
3MP:00053858.9IL10, LTA, NID1, SCYL1, TLR3, TNF
4MP:00053917.8IL10, IL4, LTA, NID1, SCYL1, TNF
5MP:00053797.8CD4, CD8A, IL10, IL4, LTA, TLR3
6MP:00053977.3CD4, CD8A, IL10, IL4, LTA, SCYL1
7MP:00053877.3CD4, CD8A, IL10, IL4, LTA, SCYL1
8MP:00107687.3CD4, CD8A, IL10, IL4, LTA, SCYL1
9MP:00036316.8CD4, CD8A, IL10, IL4, LTA, NID1

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Miconazoleapproved, investigational, vet_approvedPhase 2, Phase 3, Phase 1370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
2
PentamidineapprovedPhase 2, Phase 341100-33-44735
Synonyms:
1,3-BIS(4-AMIDINOPHENOXY)PENTANE
1,3-Bis(4-amidinophenoxy)pentane
1,5-Bis(4-amidinophenoxy)pentane
100-33-4
4, 4'-Diamidinodiphenoxypentane
4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide
4,4'-(Pentamethylenedioxy)dibenzamide
4,4'-(Pentamethylenedioxy)dibenzamidine
4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane
4,4'-Diamidinodiphenoxypentane
4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
4-10-00-00447 (Beilstein Handbook Reference)
4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
6823-79-6
AB00053572
AC-12459
AC1L1IU8
AC1Q4YYD
BPBio1_000689
BRN 3159790
BSPBio_000625
BSPBio_001752
Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis- (9CI)
C07420
C19H24N4O2
CCRIS 3825
CHEBI:45081
CHEMBL55
CID4735
D08333
DB00738
EINECS 202-841-0
HMS2089J14
HSDB 7474
KBio3_001252
KBioGR_000879
LS-27566
Lomidine
Lomidine (TN)
MB 800
MB-800
MolPort-001-792-506
NCGC00179034-01
NCGC00179034-02
NCI60_042221
NSC 9921
 
NSC620107
NSC9921
Nebupent
Nebupent (*Isethionate)
Nebupent (as isethionate)
P,P'-(pentamethylenedioxy)dibenzamidine
PENTAM
PENTAMIDINE ISETHIONATE
PNT
Pentacarinat
Pentacarinat (*Isethionate)
Pentacarinat (as isethionate)
Pentam 300
Pentam 300 (*Isethionate)
Pentam 300 (as isethionate)
Pentamide
Pentamidin
Pentamidina
Pentamidina [DCIT]
Pentamidindiisetionat
Pentamidine
Pentamidine (INN)
Pentamidine Isethionate
Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid
Pentamidine [INN:BAN:DCF]
Pentamidine isetionate
Pentamidine mesylate
Pentamidinum
Pentamidinum [INN-Latin]
Pneumopent
Prestwick1_000553
Prestwick2_000553
Prestwick3_000553
RP 2512 (*Isethionate)
RP-2512
SPBio_000290
SPBio_002546
Spectrum2_000155
Spectrum3_000276
Spectrum4_000380
Spectrum5_001808
UNII-673LC5J4LQ
WLN: MUYZR DO5OR DYZUM
nchembio873-comp32
p,p'-(Pentamethylene-dioxy)bis-benzamidine
p,p'-(Pentamethylenedioxy)bis[benzamidine]
p,p'-(Pentamethylenedioxy)dibenzamidine
pentamidine
3
Lidocaineapproved, vet_approvedPhase 2, Phase 31317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
4
Paromomycinapproved, investigationalPhase 2, Phase 3311263-89-4, 7542-37-2165580
Synonyms:
(1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol
7542-37-2
84420-34-8
AC1L4WW9
Aminosidin
Aminosidine
Aminosidine, sulfate
C00832
CHEMBL370143
CID165580
Catenulin
Crestomycin
D07467
DB01421
Estomycin
Human .alpha.-1-antitrypsin & Paromomyin
Humatin
Hydroxymycin
Hydroxymycin sulfate
MolPort-002-510-747
Monomycin a
NSC227228
Neomycin E
 
Neomycin e
O-2-Amino-2-deoxy-.alpha.-D-glucopyranosyl-(1->4)-O-[O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1->3)-.beta.D-ribofuranosyl(1->5)]-2-deoxy-D-streptamine
PA1-PA2-PA3-PA4
PAROMOMYCIN
PAROMOMYCIN I, AMMINOSIDIN, CATENULIN, CRESTOMYCIN, MONOMYCIN A, NEOMYCIN E
Paramomycin Sulfate
Paramomycin sulfate
Paramomycin sulphate
Paromomicina
Paromomycin (INN)
Paromomycin (TN)
Paromomycin (complex)
Paromomycin I
Paromomycin i
Paromomycin sulfate Rx346208
Paromomycine
Paromomycinum
Paucimycin
Paucimycinum
R 400
R-400
STOCK1N-08708
Zygomycin a1
catenulin
hATT & Paromomycin
paromomycin
5Anti-Infective AgentsPhase 2, Phase 3, Phase 122062
6Antiparasitic AgentsPhase 2, Phase 3, Phase 12199
7Antiprotozoal AgentsPhase 2, Phase 3, Phase 12051
8Antifungal AgentsPhase 2, Phase 3, Phase 13696
9meglumine antimoniatePhase 2, Phase 327
10Anti-Bacterial AgentsPhase 2, Phase 311226
11
Amphotericin Bapproved, investigationalPhase 1, Phase 21211397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
CID1972
 
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
12
MiltefosineapprovedPhase 2, Phase 13558066-85-63600
Synonyms:
1-Hexadecylphosphorylcholine
2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt
3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide
4-04-00-01460 (Beilstein Handbook Reference)
58066-85-6
AC1L1GAH
BRN 3690495
Baxter Oncology brand of miltefosine
Baxter brand of miltefosine
C039128
C15H32.C7H17NO4P
CHEBI:125047
CHEMBL125
CID3599
Choline hydroxide, hexadecyl hydrogen phosphate, inner salt
Choline phosphate, hexadecyl ester, hydroxide, inner salt
Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI)
Choline, hexadecyl hydrogen phosphate, inner salt
D 18506
D-18506
D02494
D18506
Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt
Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt
H-1850
HDPC
HMS1922D16
HMS2089J15
HePC
Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate
 
Hexadecylphosphocholine
Hexadecylphosphorylcholine
I14-7244
IN1227
Impavido
LS-65132
M-7200
Miltefosin
Miltefosin C
Miltefosina
Miltefosina [INN-Spanish]
Miltefosine
Miltefosine (INN)
Miltefosine [INN:BAN]
Miltefosinum
Miltefosinum [INN-Latin]
Miltex
Miltéfosine
MolPort-003-665-519
Monohexadecylphosphocholine
Monohexadecylphosphorylcholine
NCGC00095169-01
NCGC00095169-02
NCGC00095169-03
NSC605583
Prasfarma brand of miltefosine
SPECTRUM1505329
ST51055612
TF-002
UNII-53EY29W7EC
hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
n-Hexadecylphosphorylcholine
13
Coal tarapprovedPhase 22028007-45-2
Synonyms:
 
Coal tars
Tar, coal
14
Pentoxifyllineapproved, investigationalPhase 21026493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
15Liposomal amphotericin BPhase 1, Phase 2121
16AnthelminticsPhase 1, Phase 2446
17Antimony Sodium GluconatePhase 1, Phase 217
18AntioxidantsPhase 23050
19Vasodilator AgentsPhase 23543
20Protective AgentsPhase 27443
21Radiation-Protective AgentsPhase 2480
22Phosphodiesterase InhibitorsPhase 21289
23Platelet Aggregation InhibitorsPhase 22516
24VaccinesPhase 16611
25
Cortisone acetateapproved691950-04-4, 50-04-45745
Synonyms:
 
Cortisyl
Cortone acetate
26
Cortisone6953-06-5222786
Synonyms:
Andreson
Anusol HC
Balneol-Hc
Colocort
Compound E
Corlin
Cortadren
Cortandren
Cortef
Cortef Acetate
Cortisal
Cortisate
Cortison
Cortisone Acetate
Cortistal
Cortivite
Cortogen
Cortone
Cortril
Dermacort
Dricort
Flexicort
 
Florinef
Fludrocortisone Acetate
Glycort
Hemsol-Hc
Hi-Cor
Incortin
Kendall'S Compound E
Kendall'S compound
Locoid
Locoid Lipocream
Micort-Hc
Nogenic HC
Orabase HCA
Pandel
Prestwick_132
Reichstein Fa
Reichstein'S Substance FA
Scheroson
Solu-Cortef
Stie-Cort
Texacort
Westcort
beta-Hc
27Anti-Inflammatory Agents10729

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Low Antimonial Dosage in American Mucosal LeishmaniasisRecruitingNCT01301937Phase 2, Phase 3
2Topical Paromomycin for Cutaneous Leishmaniasis in BoliviaNot yet recruitingNCT03096457Phase 2, Phase 3
3Clinical Trial of Miltefosine to Treat Mucosal LeishmaniasisCompletedNCT01377974Phase 2
4Miltefosine to Treat Mucocutaneous LeishmaniasisCompletedNCT01050907Phase 2
5Miltefosine for Mucosal LeishmaniasisCompletedNCT00373776Phase 1, Phase 2
6Miltefosine (Long Course) for Bolivian Mucosal LeishmaniasisCompletedNCT00373568Phase 1, Phase 2
7Use of Sodium Stibogluconate as a Treatment for LeishmaniasisCompletedNCT00657618Phase 1, Phase 2
8Sodium Stibogluconate Treatment of LeishmaniasisCompletedNCT00662012Phase 2
9Miltefosine to Treat Cutaneous Leishmaniasis in BoliviaCompletedNCT00233545Phase 2
10The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in BrazilRecruitingNCT02530697Phase 2
11Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal LeishmaniasisCompletedNCT00111514Phase 1
12Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous LeishmaniasisRecruitingNCT02429518
13Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous LeishmaniasisRecruitingNCT02431429
14Diagnosis and Treatment of Leishmanial InfectionsRecruitingNCT00344188
15Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World LeishmaniasisAvailableNCT00508963
16Cortisone and QTc-IntervalNot yet recruitingNCT03082339

Search NIH Clinical Center for Mucocutaneous Leishmaniasis


Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

36
T cells, Testes, Skin, Monocytes

Publications for Mucocutaneous Leishmaniasis

About this section

Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Mucocutaneous leishmaniasis. (26994882)
2016
2
Mucocutaneous leishmaniasis with marked facial disfigurement. (27643545)
2016
3
Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient. (27890957)
2016
4
Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. (25442251)
2015
5
Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome. (26154873)
2015
6
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. (25661291)
2015
7
Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. (25645330)
2015
8
Mucocutaneous leishmaniasis of the nose: a case report. (26513953)
2015
9
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. (25946238)
2015
10
Mucocutaneous leishmaniasis caused by Leishmania infantum var Lombardi in an immunocompetent patient, Spain. (25559703)
2015
11
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. (26568335)
2015
12
Polymerase chain reaction-miniexon: a promising diagnostic method for mucocutaneous leishmaniasis. (26452681)
2015
13
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. (25830540)
2015
14
Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. (26568336)
2015
15
A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)
2014
16
Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. (24126182)
2014
17
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. (24897964)
2014
18
Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash. (25548691)
2014
19
Mucocutaneous leishmaniasis caused by Leishmania donovani infection in an Indian man. (25557311)
2014
20
Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area. (24923211)
2014
21
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
22
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. (23148292)
2013
23
Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. (24170665)
2013
24
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. (23867693)
2013
25
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? (22434112)
2013
26
First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. (23669431)
2013
27
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
28
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
29
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
30
Primary lesion of mucocutaneous leishmaniasis simulating external otitis. (23108835)
2012
31
Mucocutaneous leishmaniasis in a patient treated with anti-TNF-I+ therapy. (22427411)
2012
32
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)
2011
33
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. (21739015)
2011
34
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. (21311023)
2011
35
Diffuse mucocutaneous leishmaniasis. (22479746)
2011
36
Treatment strategies for mucocutaneous leishmaniasis. (20606970)
2010
37
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
38
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. (20377337)
2010
39
Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. (20375822)
2010
40
Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. (20163267)
2010
41
A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. (20465699)
2010
42
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
43
Interventions for American cutaneous and mucocutaneous leishmaniasis. (19370612)
2009
44
The value of the otorhinolaryngologic exam in correct mucocutaneous leishmaniasis diagnosis. (19706900)
2009
45
Cutaneous and mucocutaneous leishmaniasis. (19889134)
2009
46
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
47
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
48
Mucocutaneous leishmaniasis treated with liposomal amphotericin B. (18368279)
2008
49
Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis. (17641726)
2007
50
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007

Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL10, TNF
29.8IL10, TNF
39.5IL4, TNF
4
Show member pathways
9.2IL10, IL4, TNF
59.2IL10, IL4, TNF
69.2IL10, IL4, TNF
79.1CD4, CD8A
89.0IL10, IL4, LTA
99.0IL10, IL4, LTA
109.0CD4, IL10, IL4
11
Show member pathways
9.0CD4, IL4, TLR3
128.7IL10, IL4, LTA, TNF
13
Show member pathways
8.7IL10, IL4, LTA, TNF
148.7IL10, IL4, LTA, TNF
158.7CD4, IL10, IL4, TNF
16
Show member pathways
8.7CD4, IL10, IL4, TNF
17
Show member pathways
8.7CD4, IL10, IL4, TNF
18
Show member pathways
8.6IL4, LTA, TLR3, TNF
19
Show member pathways
8.5CD4, CD8A, IL4
208.5CD4, CD8A, IL10, TNF
21
Show member pathways
8.4CD4, IL10, LTA, TLR3, TNF
228.2CD4, CD8A, IL4, TNF
23
Show member pathways
8.1CD4, IL10, IL4, LTA, TNF
24
Show member pathways
8.1CD4, IL10, IL4, LTA, TNF
258.0CD8A, IL10, IL4, TLR3, TNF
26
Show member pathways
7.8CD4, CD8A, IL10, IL4, TNF
277.8CD4, CD8A, IL10, IL4, TNF
28
Show member pathways
7.8CD4, IL10, IL4, LTA, TLR3, TNF
29
Show member pathways
7.3CD4, CD8A, IL10, IL4, LTA, TNF
307.3CD4, CD8A, IL10, IL4, LTA, TNF

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.2CD4, CD8A, TLR3, TNF
2T cell receptor complexGO:00421019.1CD4, CD8A
3external side of plasma membraneGO:00098978.9CD4, CD8A, IL4, TNF
4extracellular regionGO:00055767.8CD8A, IL10, IL4, LTA, NID1, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1endothelial cell apoptotic processGO:007257710.5IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:000274010.5IL10, TNF
3negative regulation of interleukin-6 productionGO:003271510.5IL10, TNF
4negative regulation of mitotic cell cycleGO:004593010.5IL10, TNF
5positive regulation of cytokine secretionGO:005071510.5IL10, TNF
6positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL10, TNF
7necroptotic signaling pathwayGO:009752710.5TLR3, TNF
8positive regulation of chemokine productionGO:003272210.5TLR3, TNF
9positive regulation of cytokine productionGO:000181910.5TLR3, TNF
10positive regulation of interleukin-8 productionGO:003275710.5TLR3, TNF
11positive regulation of NF-kappaB import into nucleusGO:004234610.5TLR3, TNF
12positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.3LTA, TNF
13positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.3LTA, TNF
14defense response to protozoanGO:004283210.2IL10, IL4
15positive regulation of mononuclear cell migrationGO:007167710.2IL4, TNF
16negative regulation of endothelial cell apoptotic processGO:200035210.2IL10, IL4
17negative regulation of nitric oxide biosynthetic processGO:004501910.2IL10, IL4
18positive regulation of MHC class II biosynthetic processGO:004534810.2IL10, IL4
19microglial cell activationGO:000177410.2IL4, TLR3
20negative regulation of osteoclast differentiationGO:004567110.2IL4, TLR3
21defense response to bacteriumGO:004274210.2IL10, TLR3, TNF
22positive regulation of vascular smooth muscle cell proliferationGO:190470710.1IL10, TNF
23receptor biosynthetic processGO:003280010.0IL10, TNF
24negative regulation of growth of symbiont in hostGO:004413010.0IL10, LTA, TNF
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.0CD4, TLR3, TNF
26positive regulation of chemokine biosynthetic processGO:00450809.9IL4, TLR3, TNF
27positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9IL10, IL4, TNF
28positive regulation of calcium-mediated signalingGO:00508509.8CD4, CD8A
29regulation of isotype switchingGO:00451919.7IL10, IL4
30type 2 immune responseGO:00420929.5IL10, IL4
31positive regulation of protein phosphorylationGO:00019349.3CD4, IL4, TLR3, TNF
32positive regulation of transcription, DNA-templatedGO:00458939.1CD4, IL10, IL4, TNF
33immune responseGO:00069558.0CD4, CD8A, IL10, IL4, LTA, TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:00150269.7CD4, CD8A
2tumor necrosis factor receptor bindingGO:00051649.6LTA, TNF
3cytokine activityGO:00051259.1IL10, IL4, LTA, TNF

Sources for Mucocutaneous Leishmaniasis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet