MCID: MCC002
MIFTS: 38

Mucocutaneous Leishmaniasis malady

Infectious diseases category

Aliases & Classifications for Mucocutaneous Leishmaniasis

About this section

Mucocutaneous Leishmaniasis, Aliases & Descriptions:

Name: Mucocutaneous Leishmaniasis 9 11 60
American Cutaneous Leishmaniasis 9 60
Mucocutaneous Leishmaniasis, American 9
American Mucocutaneous Leishmaniasis 9
 
New World Cutaneous Leishmaniasis 9
Cutaneous Leishmaniasis, American 9
Mucocutaneous Leishmaniasis, 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:9155
ICD9CM27 085.4, 085.5
NCIt38 C34769
MeSH33 D007897
ICD1025 B55.2

Summaries for Mucocutaneous Leishmaniasis

About this section


Disease Ontology:9 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Amoebiasis and Spinal Cord Injury. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and skin.

Related Diseases for Mucocutaneous Leishmaniasis

About this section

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Symptoms for Mucocutaneous Leishmaniasis

About this section

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

About this section

Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

About this section

Anatomical Context for Mucocutaneous Leishmaniasis

About this section

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

31
T cells, Testes, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

About this section

Publications for Mucocutaneous Leishmaniasis

About this section

Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. (25442251)
2015
2
A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)
2014
3
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. (24897964)
2014
4
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
5
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
6
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
7
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
8
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
9
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
10
Cutaneous and mucocutaneous leishmaniasis. (19889134)
2009
11
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
12
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
13
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)
2007
14
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007
15
Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. (16991092)
2006
16
Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. (16574379)
2006
17
A case of mucocutaneous leishmaniasis. (15886638)
2005
18
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
19
Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)
2004
20
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
21
A case of mucocutaneous leishmaniasis. (11816390)
2002
22
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
23
Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)
1999
24
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
25
Imported mucocutaneous leishmaniasis. (8974832)
1996
26
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
27
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
28
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
29
American mucocutaneous leishmaniasis. (7805299)
1994
30
Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)
1993
31
American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)
1992
32
Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)
1991
33
Prevalence of mucocutaneous leishmaniasis in littoral Bahia, Brazil. (2389315)
1990
34
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
35
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
36
Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)
1988
37
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
38
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
39
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
40
Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)
1981
41
Immunoenzymatic assy (ELISA) in mucocutaneous leishmaniasis, kala-azar, and Chagas' disease: an epimastigote Trypanosoma cruzi antigen able to distinguish between anti-Trypanosoma and anti-Leishmania antibodies. (6792937)
1981
42
The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)
1981
43
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
44
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
45
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
46
Use of amphotericin B in mucocutaneous leishmaniasis. (933229)
1976
47
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
48
THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)
1963
49
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960
50
Mucocutaneous leishmaniasis in Kenya, with a note on penicillin treatment. (20243886)
1947

Variations for Mucocutaneous Leishmaniasis

About this section

Expression for genes affiliated with Mucocutaneous Leishmaniasis

About this section
Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

About this section

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IFNG
29.5TNF, IFNG
3
Show member pathways
Immune response MIF in innate immunity response58
9.5TNF, IFNG
49.5IFNG, TNF
5
Show member pathways
thioredoxin pathway36
9.5IFNG, TNF
6
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5TNF, IFNG
79.5IFNG, TNF
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.5IFNG, TNF
99.5TNF, IFNG
10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.5IFNG, TNF
11
Show member pathways
9.5TNF, IFNG
129.5TNF, IFNG
13
Show member pathways
9.5TNF, IFNG
14
Show member pathways
9.5TNF, IFNG
159.5TNF, IFNG
169.5IFNG, TNF
179.5IFNG, TNF
189.5IFNG, TNF
19
Show member pathways
9.5IFNG, TNF
209.5IFNG, TNF
21
Show member pathways
9.5IFNG, TNF
229.5IFNG, TNF
23
Show member pathways
IL27-mediated signaling events36
9.5IFNG, TNF
249.5TNF, IFNG
25
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.5IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.5TNF, IFNG
279.5TNF, IFNG
288.6IFNG, ENTPD3, ENTPD8

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

About this section

Compounds related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1interferon gamma4310.0IFNG, TNF
2taurine chloramine439.9IFNG, TNF
3vesnarinone439.9IFNG, TNF
4gold sodium thiomalate439.9TNF, IFNG
5natalizumab43 1210.9IFNG, TNF
6il-12439.9IFNG, TNF
7adalimumab43 49 1211.9TNF, IFNG
8staurosporin439.9TNF, IFNG
9indoleamine439.9TNF, IFNG
10imiquimod43 59 28 1212.9TNF, IFNG
11polymyxin b439.9IFNG, TNF
12okt3439.9IFNG, TNF
13gm-csf43 2810.9TNF, IFNG
14triptolide439.9TNF, IFNG
15parthenolide43 210.9IFNG, TNF
16budesonide43 49 1211.9IFNG, TNF
17fluticasone propionate43 49 59 1212.9TNF, IFNG
182,5-oligoadenylate439.8IFNG, TNF
19polyinosinic-polycytidylic acid439.8IFNG, TNF
20rolipram43 59 2811.8IFNG, TNF
21etanercept43 49 1211.8IFNG, TNF
22poly(i-c)439.8IFNG, TNF
23il 10439.8IFNG, TNF
24mycophenolate mofetil43 49 1211.8IFNG, TNF
25l-nmma439.8IFNG, TNF
26infliximab43 49 1211.8TNF, IFNG
27glucosamine43 24 1211.8IFNG, TNF
28tarc439.7IFNG, TNF
29ivig439.7TNF, IFNG
30ccl343 2810.7TNF, IFNG
31pentoxifylline43 1210.7IFNG, TNF
32melphalan43 49 1211.6TNF, IFNG
33neopterin439.6TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2439.6TNF, IFNG
35pdtc439.5IFNG, TNF
36lactacystin439.5IFNG, TNF
37Thymidine 3',5'-cyclic monophosphate249.5ENTPD3, ENTPD8
385-Thymidylic acid249.5ENTPD3, ENTPD8
39Uridine 5'-monophosphate249.5ENTPD8, ENTPD3
40dTDP249.5ENTPD8, ENTPD3
41IDP249.5ENTPD8, ENTPD3
42Inosinic acid24 1210.4ENTPD3, ENTPD8
43inosine triphosphate43 2410.4ENTPD3, ENTPD8
44Cytidine monophosphate249.4ENTPD8, ENTPD3
45CDP249.4ENTPD8, ENTPD3
46Uridine triphosphate249.4ENTPD3, ENTPD8
47thalidomide43 49 59 1212.4IFNG, TNF
48Thymidine 5'-triphosphate249.4ENTPD8, ENTPD3
49Cytidine triphosphate249.4ENTPD3, ENTPD8
50Uridine 5'-diphosphate248.7ENTPD3, ENTPD8

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

About this section

Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.5IFNG, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:00605579.8TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:00605599.7TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:00450809.7TNF, IFNG
4positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IFNG, TNF
5negative regulation of growth of symbiont in hostGO:00441309.7TNF, IFNG
6positive regulation of osteoclast differentiationGO:00456729.6IFNG, TNF
7protein import into nucleus, translocationGO:00000609.6IFNG, TNF
8positive regulation of nitric oxide biosynthetic processGO:00454299.6TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:00971919.5IFNG, TNF
10response to virusGO:00096159.5TNF, IFNG
11humoral immune responseGO:00069599.4TNF, IFNG
12regulation of insulin secretionGO:00507969.2TNF, IFNG

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.5IFNG, TNF
2nucleoside-diphosphatase activityGO:00171108.9ENTPD8, ENTPD3
3nucleoside-triphosphatase activityGO:00171118.7ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Mucocutaneous Leishmaniasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet