MCID: MCC002
MIFTS: 45

Mucocutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Mucocutaneous Leishmaniasis

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Disease Ontology:9 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american mucocutaneous leishmaniasis, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Amoebiasis and Spinal Cord Injury. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

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Mucocutaneous Leishmaniasis, Aliases & Descriptions:

Name: Mucocutaneous Leishmaniasis 9 11 61
American Mucocutaneous Leishmaniasis 9 61
New World Cutaneous Leishmaniasis 9 61
American Cutaneous Leishmaniasis 9 61
 
Mucocutaneous Leishmaniasis, American 9
Cutaneous Leishmaniasis, American 9
Mucocutaneous Leishmaniasis, 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:9155
MeSH34 D007897
NCIt39 C34769
ICD9CM28 085.5, 085.4
ICD1026 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

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Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Symptoms for Mucocutaneous Leishmaniasis

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Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

32
Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

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Publications for Mucocutaneous Leishmaniasis

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Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)
2014
2
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. (24897964)
2014
3
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
4
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
5
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
6
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
7
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
8
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
9
Cutaneous and mucocutaneous leishmaniasis. (19889134)
2009
10
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
11
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
12
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)
2007
13
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007
14
Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. (16991092)
2006
15
Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. (16574379)
2006
16
A case of mucocutaneous leishmaniasis. (15886638)
2005
17
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
18
Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)
2004
19
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
20
A case of mucocutaneous leishmaniasis. (11816390)
2002
21
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
22
Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)
1999
23
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
24
Imported mucocutaneous leishmaniasis. (8974832)
1996
25
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
26
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
27
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
28
American mucocutaneous leishmaniasis. (7805299)
1994
29
Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)
1993
30
American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)
1992
31
Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)
1991
32
Prevalence of mucocutaneous leishmaniasis in littoral Bahia, Brazil. (2389315)
1990
33
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
34
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
35
Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)
1988
36
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
37
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
38
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
39
Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)
1981
40
Immunoenzymatic assy (ELISA) in mucocutaneous leishmaniasis, kala-azar, and Chagas' disease: an epimastigote Trypanosoma cruzi antigen able to distinguish between anti-Trypanosoma and anti-Leishmania antibodies. (6792937)
1981
41
The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)
1981
42
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
43
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
44
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
45
Use of amphotericin B in mucocutaneous leishmaniasis. (933229)
1976
46
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
47
Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)
1974
48
THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)
1963
49
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960
50
Mucocutaneous leishmaniasis in Kenya, with a note on penicillin treatment. (20243886)
1947

Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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Pathways related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNG, TNF
29.5TNF, IFNG
3
Show member pathways
Immune response MIF in innate immunity response59
9.5IFNG, TNF
49.5TNF, IFNG
5
Show member pathways
thioredoxin pathway37
9.5IFNG, TNF
6
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.5IFNG, TNF
79.5IFNG, TNF
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.5IFNG, TNF
99.5IFNG, TNF
10
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.5IFNG, TNF
11
Show member pathways
9.5IFNG, TNF
12
Show member pathways
9.5TNF, IFNG
139.5TNF, IFNG
14
Show member pathways
9.5IFNG, TNF
159.5TNF, IFNG
169.5IFNG, TNF
179.5IFNG, TNF
189.5TNF, IFNG
19
Show member pathways
9.5IFNG, TNF
209.5IFNG, TNF
21
Show member pathways
9.5TNF, IFNG
229.5IFNG, TNF
23
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5TNF, IFNG
24
Show member pathways
IL27-mediated signaling events37
9.5TNF, IFNG
259.5TNF, IFNG
26
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.5TNF, IFNG
279.5IFNG, TNF
288.6ENTPD8, ENTPD3, IFNG

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

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Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.0IFNG, TNF
2vesnarinone449.9TNF, IFNG
3taurine chloramine449.9TNF, IFNG
4gold sodium thiomalate449.9IFNG, TNF
5natalizumab44 1210.9IFNG, TNF
6il-12449.9IFNG, TNF
7adalimumab44 50 1211.9TNF, IFNG
8staurosporin449.9TNF, IFNG
9indoleamine449.9TNF, IFNG
10imiquimod44 60 29 1212.9TNF, IFNG
11polymyxin b449.9TNF, IFNG
12okt3449.9IFNG, TNF
13gm-csf44 2910.9TNF, IFNG
14triptolide449.9TNF, IFNG
15parthenolide44 310.9TNF, IFNG
16budesonide44 50 1211.9TNF, IFNG
17fluticasone propionate44 50 60 1212.9IFNG, TNF
18polyinosinic-polycytidylic acid449.8IFNG, TNF
192,5-oligoadenylate449.8IFNG, TNF
20rolipram44 60 2911.8TNF, IFNG
21etanercept44 50 1211.8IFNG, TNF
22poly(i-c)449.8IFNG, TNF
23il 10449.8TNF, IFNG
24mycophenolate mofetil44 50 1211.8TNF, IFNG
25l-nmma449.8IFNG, TNF
26tarc449.8TNF, IFNG
27infliximab44 50 1211.8TNF, IFNG
28glucosamine44 25 1211.7TNF, IFNG
29ivig449.7IFNG, TNF
30ccl344 2910.7TNF, IFNG
31pentoxifylline44 1210.7TNF, IFNG
32melphalan44 50 1211.6IFNG, TNF
33neopterin449.6TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2449.6IFNG, TNF
35pdtc449.5IFNG, TNF
36lactacystin449.5IFNG, TNF
37Thymidine 3',5'-cyclic monophosphate259.5ENTPD8, ENTPD3
385-Thymidylic acid259.5ENTPD8, ENTPD3
39Uridine 5'-monophosphate259.5ENTPD3, ENTPD8
40dTDP259.5ENTPD8, ENTPD3
41IDP259.5ENTPD3, ENTPD8
42Inosinic acid25 1210.5ENTPD3, ENTPD8
43inosine triphosphate44 2510.4ENTPD3, ENTPD8
44Cytidine monophosphate259.4ENTPD3, ENTPD8
45CDP259.4ENTPD8, ENTPD3
46Uridine triphosphate259.4ENTPD3, ENTPD8
47thalidomide44 50 60 1212.4TNF, IFNG
48Thymidine 5'-triphosphate259.4ENTPD8, ENTPD3
49Cytidine triphosphate259.4ENTPD3, ENTPD8
50Uridine 5'-diphosphate258.7ENTPD8, ENTPD3

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5IFNG, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.6IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
9extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
10response to virusGO:0096159.5IFNG, TNF
11humoral immune responseGO:0069599.4TNF, IFNG
12regulation of insulin secretionGO:0507969.2IFNG, TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IFNG, TNF
2nucleoside-diphosphatase activityGO:0171108.9ENTPD8, ENTPD3
3nucleoside-triphosphatase activityGO:0171118.7ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

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Sources for Mucocutaneous Leishmaniasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet