MCID: MCC002
MIFTS: 46

Mucocutaneous Leishmaniasis malady

Infectious diseases category
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Summaries for Mucocutaneous Leishmaniasis

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Disease Ontology:8 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american mucocutaneous leishmaniasis, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Amoebiasis and Spinal Cord Injury. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

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Mucocutaneous Leishmaniasis, Aliases & Descriptions:

Name: Mucocutaneous Leishmaniasis 8 10 62
American Mucocutaneous Leishmaniasis 8 62
New World Cutaneous Leishmaniasis 8 62
American Cutaneous Leishmaniasis 8 62
 
Mucocutaneous Leishmaniasis, American 8
Cutaneous Leishmaniasis, American 8
Mucocutaneous Leishmaniasis, 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:9155
MeSH34 D007897
NCIt39 C34769
ICD9CM27 085.5, 085.4
ICD1025 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

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Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Symptoms for Mucocutaneous Leishmaniasis

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Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

32
Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

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Publications for Mucocutaneous Leishmaniasis

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Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)
2014
2
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. (24897964)
2014
3
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
4
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
5
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
6
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
7
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
8
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
9
Cutaneous and mucocutaneous leishmaniasis. (19889134)
2009
10
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
11
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
12
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)
2007
13
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007
14
Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. (16991092)
2006
15
Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. (16574379)
2006
16
A case of mucocutaneous leishmaniasis. (15886638)
2005
17
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
18
Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)
2004
19
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
20
A case of mucocutaneous leishmaniasis. (11816390)
2002
21
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
22
Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)
1999
23
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
24
Imported mucocutaneous leishmaniasis. (8974832)
1996
25
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
26
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
27
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
28
American mucocutaneous leishmaniasis. (7805299)
1994
29
Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)
1993
30
American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)
1992
31
Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)
1991
32
Prevalence of mucocutaneous leishmaniasis in littoral Bahia, Brazil. (2389315)
1990
33
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
34
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
35
Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)
1988
36
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
37
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
38
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
39
Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)
1981
40
Immunoenzymatic assy (ELISA) in mucocutaneous leishmaniasis, kala-azar, and Chagas' disease: an epimastigote Trypanosoma cruzi antigen able to distinguish between anti-Trypanosoma and anti-Leishmania antibodies. (6792937)
1981
41
The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)
1981
42
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
43
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
44
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
45
Use of amphotericin B in mucocutaneous leishmaniasis. (933229)
1976
46
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
47
Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)
1974
48
THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)
1963
49
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960
50
Mucocutaneous leishmaniasis in Kenya, with a note on penicillin treatment. (20243886)
1947

Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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Pathways related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IFNG
29.5TNF, IFNG
3
Show member pathways
Immune response MIF in innate immunity response60
9.5TNF, IFNG
49.5IFNG, TNF
5
Show member pathways
thioredoxin pathway37
9.5IFNG, TNF
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5TNF, IFNG
79.5IFNG, TNF
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5IFNG, TNF
99.5TNF, IFNG
10
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.5IFNG, TNF
11
Show member pathways
9.5TNF, IFNG
129.5TNF, IFNG
13
Show member pathways
9.5TNF, IFNG
14
Show member pathways
9.5TNF, IFNG
159.5TNF, IFNG
169.5IFNG, TNF
179.5IFNG, TNF
189.5IFNG, TNF
19
Show member pathways
9.5IFNG, TNF
209.5IFNG, TNF
21
Show member pathways
9.5IFNG, TNF
229.5IFNG, TNF
23
Show member pathways
IL27-mediated signaling events37
9.5IFNG, TNF
249.5TNF, IFNG
25
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.5TNF, IFNG
279.5TNF, IFNG
288.6IFNG, ENTPD3, ENTPD8

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

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Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.0IFNG, TNF
2taurine chloramine449.9IFNG, TNF
3vesnarinone449.9IFNG, TNF
4gold sodium thiomalate449.9TNF, IFNG
5natalizumab44 1110.9IFNG, TNF
6il-12449.9IFNG, TNF
7adalimumab44 50 1111.9TNF, IFNG
8staurosporin449.9TNF, IFNG
9indoleamine449.9TNF, IFNG
10imiquimod44 61 28 1112.9TNF, IFNG
11polymyxin b449.9IFNG, TNF
12okt3449.9IFNG, TNF
13gm-csf44 2810.9TNF, IFNG
14triptolide449.9TNF, IFNG
15parthenolide44 210.9IFNG, TNF
16budesonide44 50 1111.9IFNG, TNF
17fluticasone propionate44 50 61 1112.9TNF, IFNG
182,5-oligoadenylate449.8IFNG, TNF
19polyinosinic-polycytidylic acid449.8IFNG, TNF
20rolipram44 61 2811.8IFNG, TNF
21etanercept44 50 1111.8IFNG, TNF
22poly(i-c)449.8IFNG, TNF
23il 10449.8IFNG, TNF
24mycophenolate mofetil44 50 1111.8IFNG, TNF
25l-nmma449.8IFNG, TNF
26infliximab44 50 1111.8TNF, IFNG
27glucosamine44 24 1111.8IFNG, TNF
28tarc449.7IFNG, TNF
29ivig449.7TNF, IFNG
30ccl344 2810.7TNF, IFNG
31pentoxifylline44 1110.7IFNG, TNF
32melphalan44 50 1111.6TNF, IFNG
33neopterin449.6TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2449.6TNF, IFNG
35pdtc449.5IFNG, TNF
36lactacystin449.5IFNG, TNF
37Thymidine 3',5'-cyclic monophosphate249.5ENTPD3, ENTPD8
385-Thymidylic acid249.5ENTPD3, ENTPD8
39Uridine 5'-monophosphate249.5ENTPD8, ENTPD3
40dTDP249.5ENTPD8, ENTPD3
41IDP249.5ENTPD8, ENTPD3
42Inosinic acid24 1110.4ENTPD3, ENTPD8
43inosine triphosphate44 2410.4ENTPD3, ENTPD8
44Cytidine monophosphate249.4ENTPD8, ENTPD3
45CDP249.4ENTPD8, ENTPD3
46Uridine triphosphate249.4ENTPD3, ENTPD8
47thalidomide44 50 61 1112.4IFNG, TNF
48Thymidine 5'-triphosphate249.4ENTPD8, ENTPD3
49Cytidine triphosphate249.4ENTPD3, ENTPD8
50Uridine 5'-diphosphate248.7ENTPD3, ENTPD8

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5IFNG, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.6IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
9extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
10response to virusGO:0096159.5IFNG, TNF
11humoral immune responseGO:0069599.4TNF, IFNG
12regulation of insulin secretionGO:0507969.2IFNG, TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IFNG, TNF
2nucleoside-diphosphatase activityGO:0171108.9ENTPD8, ENTPD3
3nucleoside-triphosphatase activityGO:0171118.7ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

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Sources for Mucocutaneous Leishmaniasis

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3CDC
13ExPASy
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25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
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62UMLS
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