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MCID: MCC002
MIFTS: 40

Mucocutaneous Leishmaniasis malady

Infectious category
6 genes, 4 tissues, 21 related diseases, clinical trials.

Summaries for Mucocutaneous Leishmaniasis

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards: Mucocutaneous Leishmaniasis, also known as mucocutaneous leishmaniasis, american, is related to cutaneous leishmaniasis and visceral leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Calcium signaling in the CD4+ TCR pathway and Downstream signaling in naive CD8+ T cells. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and t cells.

Aliases & Classifications for Mucocutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
ICD10: 25


Aliases & Descriptions:

mucocutaneous leishmaniasis 8 10 61
mucocutaneous leishmaniasis, american 8
american mucocutaneous leishmaniasis 8
new world cutaneous leishmaniasis 8
cutaneous leishmaniasis, american 8
american cutaneous leishmaniasis 8
mucocutaneous leishmaniasis, 8


External Ids:

Disease Ontology8 DOID:9155
ICD9CM27 085.4, 085.5
MeSH35 D007897
NCIt40 C34769
ICD1025 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis31.3PKD2L1
2visceral leishmaniasis30.2PKD2L1
3granulomatous dermatitis10.3
4erysipeloid10.3
5pulmonary tuberculosis10.2
6tuberculosis10.2
7yaws10.2
8cellulitis10.1
9chagas disease10.1
10tuberculoid leprosy10.1
11borderline leprosy10.1
12lepromatous leprosy10.1
13chronic dacryocystitis10.1
14acquired immunodeficiency syndrome10.1
15aids dementia complex10.0TNF
16leishmaniasis10.0IFNG
17acute graft versus host disease10.0TNF, IFNG
18cerebral malaria10.0IFNG, TNF
19toxic shock syndrome10.0TNF, IFNG
20pulmonary sarcoidosis10.0TNF, IFNG
21graft versus host disease10.0TNF, IFNG

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Clinical Features for Mucocutaneous Leishmaniasis

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Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Mucocutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Search CenterWatch for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

33
Skin, Monocytes, T cells, B cells

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

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Sources:
28inGenious Targeting Laboratory
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Publications for Mucocutaneous Leishmaniasis

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51PubMed
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Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
2
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. (23148292)
2013
3
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. (23867693)
2013
4
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
5
Diffuse mucocutaneous leishmaniasis. (22479746)
2011
6
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)
2011
7
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. (21311023)
2011
8
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. (21739015)
2011
9
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
10
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. (20377337)
2010
11
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
12
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
13
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
14
Eco-epidemiological survey of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in Ribeira Valley River, ParanA! State, Brazil. (15652328)
2005
15
Mucocutaneous leishmaniasis presenting as facial cellulitis. (16175986)
2005
16
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
17
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
18
Epidemiological and clinical features of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in the State of EspA-rito Santo, Brazil. (15049080)
2003
19
Mucocutaneous leishmaniasis in a patient with the human immunodeficiency virus. (11564337)
2001
20
Use of itraconazole in the treatment of mucocutaneous leishmaniasis: a pilot study. (11179919)
2000
21
Polymerase chain reaction reveals Trypanosoma cruzi infection suspected by serology in cutaneous and mucocutaneous leishmaniasis patients. (10232785)
1999
22
PCR-ELISA for diagnosis of mucocutaneous leishmaniasis. (10379813)
1999
23
Efficacy of sodium stibogluconate alone and in combination with allopurinol for treatment of mucocutaneous leishmaniasis. (9314461)
1997
24
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
25
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
26
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
27
American mucocutaneous leishmaniasis. (7805299)
1994
28
T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis. (7496967)
1994
29
Mucocutaneous leishmaniasis and HIV. (7949483)
1994
30
Quantitative study of Leishmania braziliensis braziliensis reactive T cells in peripheral blood and in the lesions of patients with American mucocutaneous leishmaniasis. (2311299)
1990
31
Mucocutaneous leishmaniasis due to Leishmania (Leishmania) infantum: biochemical characterization. (2267965)
1990
32
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
33
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
34
Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis). (2687621)
1988
35
Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. (2437815)
1987
36
Evaluation of T-cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis. (2957642)
1987
37
Evaluation of dot enzyme-linked immunosorbent assay for mucocutaneous leishmaniasis and comparison with microplate enzyme immunoassay. (3531227)
1986
38
Failure to detect circulating Leishmania in mucocutaneous leishmaniasis due to Leishmania braziliensis braziliensis. (3787695)
1986
39
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
40
Identification of human stocks of Leishmania spp. isolated from patients with mucocutaneous leishmaniasis in TrA-s BraAsos, Bahia, Brazil. (6506171)
1984
41
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
42
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
43
Renal tubular dysfunction in patients with mucocutaneous leishmaniasis treated with pentavalent antimonials. (6136717)
1983
44
Parasitologic and immunologic diagnosis of American (mucocutaneous) leishmaniasis. (7030439)
1981
45
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
46
Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. (434070)
1979
47
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
48
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
49
Mucocutaneous leishmaniasis in guinea-pigs inoculated intravenously with Leishmania enriettii. Preliminary report. (1182080)
1975
50
Visceral manifestations of American mucocutaneous leishmaniasis. (13282931)
1956

Genetic Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 30KEGG, 54Reactome, 52QIAGEN
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Pathways related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Calcium signaling in the CD4+ TCR pathway38
Hide members
9.6TNF, IFNG
2
Downstream signaling in naive CD8+ T cells38
9.6TNF, IFNG
3
TGF Beta Signaling Pathway38
9.6IFNG, TNF
4
IL27-mediated signaling events38
Hide members
9.6IFNG, TNF
5
Immune response Bacterial infections in normal airways
9.6TNF, IFNG
6
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.6TNF, IFNG
7
Malaria30
9.6TNF, IFNG
8
RIP-mediated NFkB activation via ZBP154
Hide members
9.6IFNG, TNF
9
Immune response MIF-mediated glucocorticoid regulation12
9.6IFNG, TNF
10
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types53
Hide members
9.6TNF, IFNG
11
Cytokines and Inflammatory Response38
9.6IFNG, TNF
12
Cytokine Network52
9.6TNF, IFNG
13
MSP-RON Signaling52
9.6TNF, IFNG
14
African trypanosomiasis30
9.6TNF, IFNG
15
Epstein-Barr virus infection30
8.9ENTPD8, ENTPD3, IFNG

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

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Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1interferon gamma4510.0TNF, IFNG
2vesnarinone4510.0TNF, IFNG
3taurine chloramine4510.0TNF, IFNG
4gold sodium thiomalate4510.0TNF, IFNG
5natalizumab45 1111.0IFNG, TNF
6adalimumab45 50 1112.0TNF, IFNG
7il-124510.0TNF, IFNG
8staurosporin4510.0IFNG, TNF
9indoleamine4510.0IFNG, TNF
10imiquimod45 29 60 1113.0TNF, IFNG
11polymyxin b4510.0TNF, IFNG
12okt3459.9IFNG, TNF
13gm-csf45 2910.9TNF, IFNG
14triptolide459.9TNF, IFNG
15budesonide45 50 1111.9IFNG, TNF
16parthenolide45 210.9IFNG, TNF
17fluticasone propionate45 50 60 1112.9TNF, IFNG
182,5-oligoadenylate459.9TNF, IFNG
19polyinosinic-polycytidylic acid459.9TNF, IFNG
20etanercept45 50 1111.9IFNG, TNF
21poly(i-c)459.9TNF, IFNG
22il 10459.8TNF, IFNG
23l-nmma459.8IFNG, TNF
24infliximab45 50 1111.8IFNG, TNF
25glucosamine45 11 2411.8TNF, IFNG
26tarc459.7TNF, IFNG
27Inosinic Acid11 2410.7ENTPD3, ENTPD8
28inosine triphosphate45 2410.7ENTPD3, ENTPD8
29ivig459.7TNF, IFNG
30ccl345 2910.6IFNG, TNF
3115-deoxy-delta-12,14-prostaglandin j2459.6TNF, IFNG
32melphalan45 1110.5TNF, IFNG
33neopterin459.3TNF, IFNG

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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16Gene Ontology
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Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.8IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8humoral immune responseGO:0069599.6TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
10positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoside-triphosphatase activityGO:0171119.3ENTPD8, ENTPD3
2nucleoside-diphosphatase activityGO:0171109.0ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Mucocutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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