MCID: MCC002
MIFTS: 45

Mucocutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Mucocutaneous Leishmaniasis

About this section
Sources:
9Disease Ontology, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards: Mucocutaneous Leishmaniasis, also known as mucocutaneous leishmaniasis, american, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Amoebiasis and Spinal Cord Injury. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

About this section
Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

mucocutaneous leishmaniasis 9 11 63
mucocutaneous leishmaniasis, american 9
american mucocutaneous leishmaniasis 9
cutaneous leishmaniasis, american 9
new world cutaneous leishmaniasis 9
american cutaneous leishmaniasis 9
mucocutaneous leishmaniasis, 9


External Ids:

Disease Ontology9 DOID:9155
NCIt41 C34769
ICD9CM28 085.5, 085.4
MeSH36 D007897
ICD1026 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Symptoms for Mucocutaneous Leishmaniasis

About this section

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Mucocutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Search CenterWatch for Mucocutaneous Leishmaniasis

Genetic Tests for Mucocutaneous Leishmaniasis

About this section

Anatomical Context for Mucocutaneous Leishmaniasis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

34
Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

About this section

Publications for Mucocutaneous Leishmaniasis

About this section
Sources:
53PubMed
See all sources

Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
2
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
3
Cutaneous and mucocutaneous leishmaniasis. (22632640)
2012
4
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
5
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
6
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
7
Cutaneous and mucocutaneous leishmaniasis. (19889134)
2009
8
Interventions for American cutaneous and mucocutaneous leishmaniasis. (19370612)
2009
9
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
10
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
11
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)
2007
12
Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)
2007
13
Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. (16991092)
2006
14
Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. (16574379)
2006
15
A case of mucocutaneous leishmaniasis. (15886638)
2005
16
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
17
Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)
2004
18
Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)
2003
19
A case of mucocutaneous leishmaniasis. (11816390)
2002
20
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
21
Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)
1999
22
Risk factors for onset of cutaneous and mucocutaneous leishmaniasis in Bolivia. (9242324)
1997
23
Cutaneous and mucocutaneous leishmaniasis. (8620680)
1996
24
Imported mucocutaneous leishmaniasis. (8974832)
1996
25
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
26
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
27
Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)
1994
28
American mucocutaneous leishmaniasis. (7805299)
1994
29
Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)
1993
30
American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)
1992
31
Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)
1991
32
Prevalence of mucocutaneous leishmaniasis in littoral Bahia, Brazil. (2389315)
1990
33
Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)
1989
34
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
35
Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)
1988
36
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)
1985
37
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
38
A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)
1983
39
Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)
1981
40
Immunoenzymatic assy (ELISA) in mucocutaneous leishmaniasis, kala-azar, and Chagas' disease: an epimastigote Trypanosoma cruzi antigen able to distinguish between anti-Trypanosoma and anti-Leishmania antibodies. (6792937)
1981
41
The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)
1981
42
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
43
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
44
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
45
Use of amphotericin B in mucocutaneous leishmaniasis. (933229)
1976
46
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
47
Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)
1974
48
THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)
1963
49
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960
50
Mucocutaneous leishmaniasis in Kenya, with a note on penicillin treatment. (20243886)
1947

Variations for Mucocutaneous Leishmaniasis

About this section

Expression for genes affiliated with Mucocutaneous Leishmaniasis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

About this section
Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 58SinoBiological, 55R&D Systems
See all sources

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IFNG
29.5TNF, IFNG
3
Show member pathways
Immune response MIF in innate immunity response61
9.5TNF, IFNG
49.5IFNG, TNF
5
Show member pathways
thioredoxin pathway39
9.5IFNG, TNF
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5TNF, IFNG
79.5IFNG, TNF
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.5IFNG, TNF
99.5TNF, IFNG
10
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.5IFNG, TNF
11
Show member pathways
9.5TNF, IFNG
129.5TNF, IFNG
13
Show member pathways
9.5TNF, IFNG
14
Show member pathways
9.5TNF, IFNG
159.5TNF, IFNG
169.5IFNG, TNF
179.5IFNG, TNF
189.5IFNG, TNF
19
Show member pathways
9.5IFNG, TNF
209.5IFNG, TNF
21
Show member pathways
9.5IFNG, TNF
229.5IFNG, TNF
23
Show member pathways
IL27-mediated signaling events39
9.5IFNG, TNF
249.5TNF, IFNG
25
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.5IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.5TNF, IFNG
279.5TNF, IFNG
288.6IFNG, ENTPD3, ENTPD8

Compounds for genes affiliated with Mucocutaneous Leishmaniasis

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
See all sources

Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1interferon gamma4610.0IFNG, TNF
2taurine chloramine469.9IFNG, TNF
3vesnarinone469.9IFNG, TNF
4gold sodium thiomalate469.9TNF, IFNG
5natalizumab46 1210.9IFNG, TNF
6il-12469.9IFNG, TNF
7adalimumab46 52 1211.9TNF, IFNG
8staurosporin469.9TNF, IFNG
9indoleamine469.9TNF, IFNG
10imiquimod46 62 30 1212.9TNF, IFNG
11polymyxin b469.9IFNG, TNF
12okt3469.9IFNG, TNF
13gm-csf46 3010.9TNF, IFNG
14triptolide469.9TNF, IFNG
15parthenolide46 310.9IFNG, TNF
16budesonide46 52 1211.9IFNG, TNF
17fluticasone propionate46 52 62 1212.9TNF, IFNG
182,5-oligoadenylate469.8IFNG, TNF
19polyinosinic-polycytidylic acid469.8IFNG, TNF
20rolipram46 62 3011.8IFNG, TNF
21etanercept46 52 1211.8IFNG, TNF
22poly(i-c)469.8IFNG, TNF
23il 10469.8IFNG, TNF
24mycophenolate mofetil46 52 1211.8IFNG, TNF
25l-nmma469.8IFNG, TNF
26infliximab46 52 1211.8TNF, IFNG
27glucosamine46 25 1211.8IFNG, TNF
28tarc469.7IFNG, TNF
29ivig469.7TNF, IFNG
30ccl346 3010.7TNF, IFNG
31pentoxifylline46 1210.7IFNG, TNF
32melphalan46 52 1211.6TNF, IFNG
33neopterin469.6TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2469.6TNF, IFNG
35pdtc469.5IFNG, TNF
36lactacystin469.5IFNG, TNF
37Thymidine 3',5'-cyclic monophosphate259.5ENTPD3, ENTPD8
385-Thymidylic acid259.5ENTPD3, ENTPD8
39Uridine 5'-monophosphate259.5ENTPD8, ENTPD3
40dTDP259.5ENTPD8, ENTPD3
41IDP259.5ENTPD8, ENTPD3
42Inosinic acid25 1210.4ENTPD3, ENTPD8
43inosine triphosphate46 2510.4ENTPD3, ENTPD8
44Cytidine monophosphate259.4ENTPD8, ENTPD3
45CDP259.4ENTPD8, ENTPD3
46Uridine triphosphate259.4ENTPD3, ENTPD8
47thalidomide46 52 62 1212.4IFNG, TNF
48Thymidine 5'-triphosphate259.4ENTPD8, ENTPD3
49Cytidine triphosphate259.4ENTPD3, ENTPD8
50Uridine 5'-diphosphate258.7ENTPD3, ENTPD8

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5IFNG, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.6IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
9extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
10response to virusGO:0096159.5IFNG, TNF
11humoral immune responseGO:0069599.4TNF, IFNG
12regulation of insulin secretionGO:0507969.2IFNG, TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IFNG, TNF
2nucleoside-diphosphatase activityGO:0171108.9ENTPD8, ENTPD3
3nucleoside-triphosphatase activityGO:0171118.7ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mucocutaneous Leishmaniasis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet