Mucocutaneous Leishmaniasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology:¹¹ A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and 12p12.1 microdeletion syndrome. An important gene associated with Mucocutaneous Leishmaniasis is TNF (Tumor Necrosis Factor), and among its related pathways are IL-10 Pathway and African trypanosomiasis. Affiliated tissues include t cells, testes and skin, and related mouse phenotypes are respiratory system and muscle.

Related Diseases for Mucocutaneous Leishmaniasis

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)

id	Related Disease	Score	Top Affiliating Genes
1	leishmaniasis	10.8
2	12p12.1 microdeletion syndrome	10.6	IL10, TNF
3	piepkorn karp hickok syndrome	10.6	IL10, TNF
4	night blindness	10.6	CD4, TNF
5	graft-versus-host disease, protection against	10.6	IL10, TNF
6	fallopian tube endometriosis	10.6	IL10, TNF
7	trichosporonosis	10.5	CD4, TNF
8	linitis plastica	10.5	CD8A, TNF
9	steatorrhea	10.5	CD4, TNF
10	addison's disease	10.5	IL10, TNF
11	suppurative uveitis	10.5	CD4, TNF
12	ocular hypertension	10.5	CD4, CD8A
13	arteriovenous malformation	10.5	CD4, CD8A
14	actinobacillosis	10.5	CD4, CD8A
15	meckel's diverticulitis	10.5	CD4, CD8A
16	endocarditis	10.5	CD4, TNF
17	chronic hiccups	10.5	CD4, IL10
18	scrotum squamous cell carcinoma	10.5	CD4, CD8A
19	hernia of ovary and fallopian tube	10.5	IL10, TNF
20	acute cystitis	10.5	CD4, CD8A
21	folliculitis	10.5	CD4, CD8A
22	cd3gamma deficiency	10.5	CD4, CD8A
23	vaccinia	10.5	CD4, CD8A
24	esophagus carcinoma in situ	10.5	CD4, CD8A
25	intestinal disaccharidase deficiency	10.5	CD4, CD8A
26	nelson syndrome	10.5	CD4, IL10
27	penis basal cell carcinoma	10.5	CD4, CD8A
28	burns	10.5	IL10, TNF
29	extrapulmonary tuberculosis	10.5	CD4, IL10
30	chronic eosinophilic pneumonia	10.5	CD4, CD8A
31	psoriasis	10.5	CD4, CD8A
32	inhalation anthrax	10.5	CD4, CD8A
33	pseudoretinitis pigmentosa	10.5	IL10, TNF
34	thoracic aortic aneurysm	10.5	CD4, TNF
35	total internal ophthalmoplegia	10.5	CD4, CD8A
36	idiopathic central precocious puberty	10.5	IL10, TNF
37	soft palate cancer	10.5	CD4, CD8A
38	agammaglobulinemia, microcephaly, and severe dermatitis	10.5	CD4, CD8A
39	sensorineural hearing loss	10.5	IL10, TNF
40	malignant eyelid melanoma	10.5	CD4, CD8A
41	conventional leiomyosarcoma	10.5	CD4, CD8A
42	gonococcal synovitis	10.5	IL4, TNF
43	psychologic dyspareunia	10.5	IL10, TNF
44	foodborne botulism	10.5	CD4, TNF
45	arachnoiditis	10.5	CD8A, TNF
46	partial third-nerve palsy	10.5	CD4, CD8A
47	mastocytosis cutaneous with short stature conductive hearing loss and microtia	10.5	IL10, TNF
48	hemophagocytic lymphohistiocytosis	10.5	IL10, TNF
49	complex partial epilepsy	10.5	CD4, CD8A
50	lymphocytic colitis	10.5	IL4, TNF

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:

Symptoms & Phenotypes for Mucocutaneous Leishmaniasis

Sources:
⁴¹MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system	MP:0005388	9.0	IL10, IL4, LTA, TLR3, TNF
2	muscle	MP:0005369	8.6	IL10, NID1, SCYL1, TLR3, TNF
3	endocrine/exocrine gland	MP:0005379	8.4	CD4, CD8A, IL10, IL4, LTA, TLR3
4	cardiovascular system	MP:0005385	8.1	IL10, LTA, NID1, SCYL1, TLR3, TNF
5	hematopoietic system	MP:0005397	7.5	CD4, CD8A, IL10, IL4, LTA, SCYL1
6	immune system	MP:0005387	7.5	CD4, CD8A, IL10, IL4, LTA, SCYL1
7	mortality/aging	MP:0010768	7.5	CD4, CD8A, IL10, IL4, LTA, SCYL1
8	vision/eye	MP:0005391	7.4	IL10, IL4, LTA, NID1, SCYL1, TNF
9	nervous system	MP:0003631	6.8	CD4, CD8A, IL10, IL4, LTA, NID1

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Anti-Infective Agents

Phase 2, Phase 3, Phase 1

21402

2

Antiprotozoal Agents

Phase 2, Phase 3, Phase 1

1986

3

meglumine antimoniate

Phase 2, Phase 3

26

4

Antiparasitic Agents

Phase 2, Phase 3, Phase 1

2127

5

Miltefosine

approved

Phase 2, Phase 1

34

58066-85-6

3600

Synonyms:

1-Hexadecylphosphorylcholine

2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt

3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide

4-04-00-01460 (Beilstein Handbook Reference)

58066-85-6

AC1L1GAH

BRN 3690495

Baxter Oncology brand of miltefosine

Baxter brand of miltefosine

C039128

C15H32.C7H17NO4P

CHEBI:125047

CHEMBL125

CID3599

Choline hydroxide, hexadecyl hydrogen phosphate, inner salt

Choline phosphate, hexadecyl ester, hydroxide, inner salt

Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI)

Choline, hexadecyl hydrogen phosphate, inner salt

D 18506

D-18506

D02494

D18506

Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt

Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt

H-1850

HDPC

HMS1922D16

HMS2089J15

HePC

Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate

Hexadecylphosphocholine

Hexadecylphosphorylcholine

I14-7244

IN1227

Impavido

LS-65132

M-7200

Miltefosin

Miltefosin C

Miltefosina

Miltefosina [INN-Spanish]

Miltefosine

Miltefosine (INN)

Miltefosine [INN:BAN]

Miltefosinum

Miltefosinum [INN-Latin]

Miltex

Miltéfosine

MolPort-003-665-519

Monohexadecylphosphocholine

Monohexadecylphosphorylcholine

NCGC00095169-01

NCGC00095169-02

NCGC00095169-03

NSC605583

Prasfarma brand of miltefosine

SPECTRUM1505329

ST51055612

TF-002

UNII-53EY29W7EC

hexadecyl 2-(trimethylazaniumyl)ethyl phosphate

n-Hexadecylphosphorylcholine

6

Miconazole

approved, investigational, vet_approved

Phase 2, Phase 1

3624

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

AKOS001574474

Aflorix(nitrate)

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

CPD-4501

Conofite(nitrate)

D00416

DB01110

Dactarin

Daktarin IV

Daktarin iv

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

LS-78378

Lotrimin AF(nitrate)

MCZ

MJR 1762

MLS002222203

Micantin (nitrate)

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

Miconazole

Miconazole (JP15/USP/INN)

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole [USAN:BAN:INN:JAN]

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (TN)

Monistat iv (tn)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

NSC 170986

NSC169434

NSC170986

Novo-Miconazole Vaginal Ovules

Oprea1_091955

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

Prestwick_335

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

STK834405

STOCK1S-93556

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

Spectrum_000965

UNII-7NNO0D7S5M

Vusion

Zimycan

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

miconazole

7

Coal tar

approved

Phase 2

191

8007-45-2

Synonyms:

Coal tars

Tar, coal

8

Amphotericin B

approved, investigational

Phase 2, Phase 1

118

1397-89-3

14956, 5280965

Synonyms:

12633-72-6

1397-89-3

30782-62-8

5-18-10-00525 (Beilstein Handbook Reference)

54482-28-9

8055-20-7

AB00513832

ABLC

AC1L1CN2

AC1L24V6

AC1L70KF

AC1L73U6

AC1NQXTD

AC1NTQ32

AC1NUQG4

AC1NY9JC

AC1O7GCZ

AC1O8FQV

AC1O8PFK

AI3-26528

AMPH-B

AMPH-b

Abelcet

Abelecet

AmBisome (TN)

Ambap1397-89-3

Ambisome

Amfotericina B

Amfotericina B [INN-Spanish]

Ampho-Moronal

Amphocin

Amphomoronal

Amphortericin B

Amphotec

Amphotec (TN)

Amphotericin

Amphotericin .BETA.

Amphotericin B

Amphotericin B (JP15/USP/INN)

Amphotericin B Cholesterol Dispersion

Amphotericin B Colloidal Dispersion

Amphotericin B [USAN:INN:JAN]

Amphotericin B, Lipid-based

Amphotericin B, Streptomyces sp.

Amphotericin-B

Amphotericine B

Amphotericine B [INN-French]

Amphotericinum

Amphotericinum B

Amphotericinum B [INN-Latin]

Amphotherizin

Amphotherizin [German]

Amphotéricine B

Amphozone

BIDD:GT0351

BPBio1_000374

BRN 0078342

BSPBio_000340

C-AmB

C06573

C47H73NO17

CCRIS 5963

CHEBI:2682

CHEMBL1200646

CHEMBL267345

CID10533925

CID10629638

CID10677275

CID14956

CID1972

CID352546

CID354192

CID5280965

CID5386092

CID5458486

CID5771695

CID6604295

CID6708817

CID6713692

CID9919339

D00203

DB00681

DivK1c_007045

EINECS 215-742-2

Fungilin

Fungisome

Fungisone

Fungizone

Fungizone (TN)

HMS1569A22

HSDB 3008

HSDB 3008 IAB

Halizon

I06-0257

KBio1_001989

KBio2_000551

KBio2_003119

KBio2_005687

KBioGR_002298

KBioSS_000551

LMPK06000002

LNS-AmB

LS-187721

LS-93

Liposomal Amphotericin B

Liposomal amphotericin b

MLS002702966

MolPort-006-392-260

Mysteclin-F

NCGC00014913

NCGC00090808-01

NCGC00098014-01

NCGC00179595-01

NCI527017

NCI60_004288

NCIStruc1_001042

NCIStruc2_000920

NKTR-024

NS 718

NSC 527017

NSC-527017

NSC527017

Prestwick0_000410

Prestwick1_000410

Prestwick2_000410

Prestwick3_000410

Prestwick_721

SMP1_000302

SMR001566780

SPBio_000715

SPBio_002279

ST50999656

SinuNase

SpecPlus_000949

Spectrum2_000818

Spectrum4_001779

Spectrum_000111

UNII-7XU7A7DROE

amophotericin B

amphotericin B liposomal

amphotericin b

9

Pentoxifylline

approved, investigational

Phase 2

99

6493-05-6

4740

Synonyms:

1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion

1-(5-Oxohexyl)-3,7-dimethylxanthine

1-(5-Oxohexyl)theobromine

2a3c

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl) xantine

3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl)xanthine

3,7-Dimethyl-1-(5-oxohexyl)xantine

3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

5-26-14-00081 (Beilstein Handbook Reference)

6493-05-6

AB00052363

AC1L1IUN

AKOS000541484

Agapurin

Agapurin Retard

Azupentat

BAS 00897429

BB_SC-2111

BIDD:GT0174

BL 191

BL-191

BL191

BPBio1_000167

BRD-K57569181-001-05-1

BRN 0558929

BSPBio_000151

BSPBio_003439

C07424

C13H18N4O3

CAS-1677687

CCRIS 6832

CHEMBL628

CID4740

CPD000035998

D00501

D010431

DB00806

Dimethyloxohexylxanthine

DivK1c_000729

Durapental

EHT 0201

EHT-0201

EHT-201

EHT0201

EINECS 229-374-5

EU-0100936

HMS1568H13

HMS1922E16

HMS2051N06

HMS2090H13

HMS2093G21

HMS502E11

Hemovas

I06-1592

IDI1_000729

IN1161

Ikomio

KBio1_000729

KBio2_001924

KBio2_004492

KBio2_007060

KBio3_002942

KBioGR_000893

KBioSS_001924

LS-149385

Lopac-P-1784

Lopac0_000936

MLS000079026

MLS000758298

MLS001201764

MolPort-001-823-263

NCGC00015801-01

NCGC00015801-02

NCGC00015801-04

NCGC00015801-10

NCGC00067069-02

NCGC00067069-03

NCGC00067069-04

NCGC00067069-05

NCGC00178062-01

NCGC00178062-02

NINDS_000729

NSC 637086

NSC637086

Oxpentifylline

P 1784

PDSP1_001015

PDSP2_000999

PENTOXYPHYLINE

PNX

Pentoxifilina

Pentoxifilina [INN-Spanish]

Pentoxifyllin

Pentoxifylline

Pentoxifylline (JAN/USP/INN)

Pentoxifylline [USAN:INN:JAN]

Pentoxifyllinum

Pentoxifyllinum [INN-Latin]

Pentoxil

Pentoxil (TN)

Pentoxiphyllin

Pentoxiphylline

Pentoxiphyllium

Pentoxyfylline

Pentoxyphyllin

Pentoxyphylline

Prestwick0_000196

Prestwick1_000196

Prestwick2_000196

Prestwick3_000196

Prestwick_608

Px

Ralofect

Rentylin

SAM001247011

SMR000035998

SPBio_001221

SPBio_002072

SPECTRUM1503611

SR-01000075641-4

STK177321

Spectrum2_001181

Spectrum3_001820

Spectrum4_000227

Spectrum5_001161

Spectrum_001444

Torental

Trental

Trental (TN)

UNII-SD6QCT3TSU

Vasofirin

Vazofirin

ZINC01530776

cis-9-Octadecenoyl coenzyme A

pentoxifylline

10

Liposomal amphotericin B

Phase 2, Phase 1

118

11

Anthelmintics

Phase 2, Phase 1

431

12

Antimony Sodium Gluconate

Phase 2, Phase 1

16

13

Antifungal Agents

Phase 2, Phase 1

3615

14

Vasodilator Agents

Phase 2

3438

15

Radiation-Protective Agents

Phase 2

466

16

Protective Agents

Phase 2

7190

17

Platelet Aggregation Inhibitors

Phase 2

2419

18

Phosphodiesterase Inhibitors

Phase 2

1254

19

Antioxidants

Phase 2

2928

20

Vaccines

Phase 1

6428

Interventional clinical trials:

(show all 14)

id	Name	Status	NCT ID	Phase
1	Low Antimonial Dosage in American Mucosal Leishmaniasis	Recruiting	NCT01301937	Phase 2, Phase 3
2	Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis	Completed	NCT01377974	Phase 2
3	Miltefosine to Treat Mucocutaneous Leishmaniasis	Completed	NCT01050907	Phase 2
4	Miltefosine for Mucosal Leishmaniasis	Completed	NCT00373776	Phase 1, Phase 2
5	Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis	Completed	NCT00373568	Phase 1, Phase 2
6	Sodium Stibogluconate Treatment of Leishmaniasis	Completed	NCT00662012	Phase 2
7	Miltefosine to Treat Cutaneous Leishmaniasis in Bolivia	Completed	NCT00233545	Phase 2
8	The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil	Recruiting	NCT02530697	Phase 2
9	Use of Sodium Stibogluconate as a Treatment for Leishmaniasis	Enrolling by invitation	NCT00657618	Phase 1, Phase 2
10	Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis	Completed	NCT00111514	Phase 1
11	Diagnosis and Treatment of Leishmanial Infections	Recruiting	NCT00344188
12	Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis	Available	NCT00508963
13	Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Not yet recruiting	NCT02429518
14	Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Not yet recruiting	NCT02431429

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

³⁶

T cells, Testes, Skin, Monocytes

Publications for Mucocutaneous Leishmaniasis

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 144)

id	Title	Authors	Year
1	Mucocutaneous leishmaniasis. (26994882)	Novoa Juiz V.... Redondo LuciaA+ez R.	2016
2	Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient. (27890957)	Bains A.... Tegta G.R.	2016
3	Mucocutaneous leishmaniasis with marked facial disfigurement. (27643545)	Ekiz O.... A9zgA1r T.	2016
4	Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. (26568336)	Handler M.Z.... Schwartz R.A.	2015
5	Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. (25661291)	Elfaituri S.S.... Emaetig F.	2015
6	Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. (25645330)	Gois L.... Grassi M.F.	2015
7	Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. (25830540)	Gomes C.M.... Sampaio R.N.	2015
8	Mucocutaneous leishmaniasis of the nose: a case report. (26513953)	Menten K.... Lemkens P.	2015
9	Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. (26568335)	Handler M.Z.... Schwartz R.A.	2015
10	Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. (25442251)	Crovetto-MartA-nez R.... Crovetto-De la Torre M.A.	2015
11	Mucocutaneous leishmaniasis caused by Leishmania infantum var Lombardi in an immunocompetent patient, Spain. (25559703)	Freites-Martinez A.... Borbujo J.	2015
12	Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. (25946238)	Gomes C.M.... Sampaio R.N.	2015
13	Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome. (26154873)	Lee G.L.... McGwire B.S.	2015
14	Polymerase chain reaction-miniexon: a promising diagnostic method for mucocutaneous leishmaniasis. (26452681)	Ovalle-Bracho C.... Muvdi-Arenas S.	2015
15	Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash. (25548691)	da Silva G.A.... Ferry F.R.	2014
16	Mucocutaneous leishmaniasis caused by Leishmania donovani infection in an Indian man. (25557311)	Daulatabad D.... Sharma S.	2014
17	A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)	Okumura Y.... Seishima M.	2014
18	Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. (24897964)	Marra F.... Vincenti V.	2014
19	Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. (24126182)	Madeddu G.... Mura M.S.	2014
20	Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area. (24923211)	Gomes C.M.... Sampaio R.N.	2014
21	Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? (22434112)	Dassoni F.... Morrone A.	2013
22	First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. (23669431)	Alborzi A.... Kalantari M.	2013
23	Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. (23867693)	de Paulo L.F.... Durighetto A.F.	2013
24	Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)	Reveiz L.... Yadon Z.E.	2013
25	Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)	Ruoti M.... Krentel A.	2013
26	Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. (23148292)	Farias L.H.... Silva E.O.	2013
27	Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. (24170665)	Monge-Maillo B.... LA^pez-VAclez R.	2013
28	Primary lesion of mucocutaneous leishmaniasis simulating external otitis. (23108835)	Silva M.d.o.s. .S.... Mubarac R.S.	2012
29	Cutaneous and mucocutaneous leishmaniasis. (22632640)	Goto H.... Lauletta Lindoso J.A.	2012
30	Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)	Fraga J.... Van der Auwera G.	2012
31	Mucocutaneous leishmaniasis in a patient treated with anti-TNF-I+ therapy. (22427411)	Garcia-Gonzalez E.... Maggio R.	2012
32	Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. (21739015)	Diniz J.L.... GonAsalves D.U.	2011
33	Diffuse mucocutaneous leishmaniasis. (22479746)	Mathur A.... Butoli J.	2011
34	Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)	Veland N.... Boggild A.K.	2011
35	Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. (21311023)	Ives A.... Masina S.	2011
36	Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. (20377337)	Goto H.... Lindoso J.A.	2010
37	Treatment strategies for mucocutaneous leishmaniasis. (20606970)	Palumbo E.	2010
38	Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)	Dorlo T.P.... Kager P.A.	2010
39	Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. (20375822)	Brahn E.... Craft N.	2010
40	A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. (20465699)	Karimbil S.K.... Joy A.	2010
41	Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. (20163267)	Ameen M.	2010
42	Interventions for American cutaneous and mucocutaneous leishmaniasis. (19370612)	GonzA!lez U.... Tweed J.A.	2009
43	Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)	Padovese V.... Morrone A.	2009
44	Cutaneous and mucocutaneous leishmaniasis. (19889134)	David C.V.... Craft N.	2009
45	The value of the otorhinolaryngologic exam in correct mucocutaneous leishmaniasis diagnosis. (19706900)	Boaventura V.S.... Barral A.	2009
46	Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)	Schleucher R.D.... Knobloch J.	2008
47	Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)	Nogueira M.F.... CucAc L.C.	2008
48	Mucocutaneous leishmaniasis treated with liposomal amphotericin B. (18368279)	Lambertucci J.R.... Silva L.C.	2008
49	Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)	Nolder D.... Miles M.A.	2007
50	Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)	Llanos-Cuentas A.... Bryceson A.	2007

Genes related to Mucocutaneous Leishmaniasis

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Mucocutaneous Leishmaniasis:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	TNF	Tumor Necrosis Factor	22.55	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
2	CD4	CD4 Molecule	15.54	DISEASES inferred ¹³
3	IL10	Interleukin 10	15.16	DISEASES inferred ¹³
4	CD8A	CD8a Molecule	15.03	DISEASES inferred ¹³
5	IL4	Interleukin 4	14.84	DISEASES inferred ¹³
6	TLR3	Toll Like Receptor 3	14.70	DISEASES inferred ¹³
7	NID1	Nidogen 1	14.61	DISEASES inferred ¹³
8	SCYL1	SCY1 Like Pseudokinase 1	14.55	DISEASES inferred ¹³
9	LTA	Lymphotoxin Alpha	14.47	DISEASES inferred ¹³

Variations for Mucocutaneous Leishmaniasis

Expression for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 25)

id	Super pathways	Score	Top Affiliating Genes
1	IL-10 Pathway⁵⁸	9.8	IL10, TNF
2	African trypanosomiasis³⁴	9.8	IL10, TNF
3	Primary immunodeficiency³⁴	9.7	CD4, CD8A
4	Toxoplasmosis³⁴ Show member pathways Leishmaniasis³⁴	9.3	IL10, IL4, TNF
5	Th2 Differentiation Pathway⁵⁹	9.3	CD4, IL10, IL4
6	IL12-mediated signaling events⁴² Show member pathways Immune response IL-12-induced IFN-gamma production⁶⁵	9.3	CD4, CD8A, IL4
7	Th17 Differentiation Pathway⁵⁹ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁹	9.2	CD4, IL4, TLR3
8	OX40 Pathway⁵⁸	9.1	IL10, IL4, LTA
9	IL4-mediated signaling events⁴²	9.1	IL10, IL4, LTA
10	Dendritic Cells Developmental Lineage Pathway⁵⁹	9.0	CD4, CD8A, IL10, TNF
11	Immune response NFAT in immune response⁶⁵ Show member pathways Immune response T cell receptor signaling pathway⁶⁵ Immune response ICOS pathway in T-helper cell⁶⁵ Immune response CD28 signaling⁶⁵	9.0	CD4, IL10, IL4, TNF
12	Cytokines and Inflammatory Response⁴²	9.0	CD4, IL10, IL4, TNF
13	Hematopoietic cell lineage³⁴	8.9	CD4, CD8A, IL4, TNF
14	G-protein signaling_RhoB regulation pathway⁶⁵	8.8	IL10, IL4, LTA, TNF
15	IgA-Producing B Cells in the Intestine⁵⁹	8.8	IL10, IL4, LTA, TNF
16	Immune response IFN alpha/beta signaling pathway⁶⁵ Show member pathways Interferon alpha/beta signaling⁶⁰ Regulation of IFNA signaling⁶⁰ Cytokine Network⁵⁸	8.8	IL10, IL4, LTA, TNF
17	Influenza A³⁴ Show member pathways Herpes simplex infection³⁴ Measles³⁴	8.7	IL4, LTA, TLR3, TNF
18	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁹	8.6	CD4, CD8A, IL10, IL4, TNF
19	B cell receptor signaling pathway (KEGG)⁴² ³⁴ Show member pathways B Cell Receptor Signaling Pathway⁴² BCR signaling pathway⁴² T cell receptor signaling pathway³⁴ B cell receptor signaling pathway³⁴ TCR Signaling Pathway⁴²	8.6	CD4, CD8A, IL10, IL4, TNF
20	PAK Pathway⁵⁸ Show member pathways Epithelial Adherens Junctions⁵⁸ Antioxidant Action of Vitamin-C⁵⁸	8.5	CD4, IL10, IL4, LTA, TNF
21	IL27-mediated signaling events⁴² Show member pathways IL-12 Family Signaling Pathways⁵⁹ Th1 Differentiation Pathway⁵⁹	8.4	CD4, IL10, LTA, TLR3, TNF
22	NF-kappaB Signaling³	8.0	CD4, CD8A, IL10, IL4, TLR3, TNF
23	Innate Lymphoid Cell Differentiation Pathways⁵⁹	8.0	CD4, CD8A, IL10, IL4, LTA, TNF
24	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Graft-versus-host disease³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ THC Differentiation Pathway⁵⁸ Antigen processing and presentation³⁴	8.0	CD4, CD8A, IL10, IL4, LTA, TNF
25	Akt Signaling⁵⁸ Show member pathways p38 Signaling⁵⁸ Tec Kinases Signaling⁵⁸	7.9	CD4, IL10, IL4, LTA, TLR3, TNF

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor complex	GO:0042101	9.7	CD4, CD8A
2	cell surface	GO:0009986	9.5	CD4, CD8A, TLR3, TNF
3	external side of plasma membrane	GO:0009897	9.3	CD4, CD8A, IL4, TNF

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cytokine secretion involved in immune response	GO:0002740	10.4	IL10, TNF
2	negative regulation of interleukin-6 production	GO:0032715	10.4	IL10, TNF
3	positive regulation of cytokine secretion	GO:0050715	10.4	IL10, TNF
4	positive regulation of calcium-mediated signaling	GO:0050850	10.4	CD4, CD8A
5	defense response to protozoan	GO:0042832	10.3	IL10, IL4
6	positive regulation of mononuclear cell migration	GO:0071677	10.3	IL4, TNF
7	negative regulation of endothelial cell apoptotic process	GO:2000352	10.3	IL10, IL4
8	necroptotic signaling pathway	GO:0097527	10.3	TLR3, TNF
9	negative regulation of nitric oxide biosynthetic process	GO:0045019	10.3	IL10, IL4
10	positive regulation of chemokine production	GO:0032722	10.3	TLR3, TNF
11	positive regulation of chronic inflammatory response to antigenic stimulus	GO:0002876	10.3	LTA, TNF
12	positive regulation of MHC class II biosynthetic process	GO:0045348	10.3	IL10, IL4
13	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO:0002925	10.3	LTA, TNF
14	positive regulation of interleukin-8 production	GO:0032757	10.3	TLR3, TNF
15	positive regulation of NF-kappaB import into nucleus	GO:0042346	10.2	TLR3, TNF
16	microglial cell activation	GO:0001774	10.2	IL4, TLR3
17	negative regulation of osteoclast differentiation	GO:0045671	10.1	IL4, TLR3
18	receptor biosynthetic process	GO:0032800	10.0	IL10, TNF
19	defense response to bacterium	GO:0042742	10.0	IL10, TLR3, TNF
20	negative regulation of growth of symbiont in host	GO:0044130	9.9	IL10, LTA, TNF
21	positive regulation of chemokine biosynthetic process	GO:0045080	9.8	IL4, TLR3, TNF
22	regulation of isotype switching	GO:0045191	9.8	IL10, IL4
23	positive regulation of protein phosphorylation	GO:0001934	9.7	IL4, TLR3, TNF
24	type 2 immune response	GO:0042092	9.6	IL10, IL4
25	positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091	9.6	IL10, IL4, TNF
26	immune response	GO:0006955	9.6	CD4, CD8A, IL10, IL4

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	10.3	CD4, CD8A
2	tumor necrosis factor receptor binding	GO:0005164	9.6	LTA, TNF
3	cytokine activity	GO:0005125	9.2	IL10, IL4, LTA, TNF