MCID: MCC002
MIFTS: 42

Mucocutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Mucocutaneous Leishmaniasis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus leishmania. the infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards: Mucocutaneous Leishmaniasis, also known as mucocutaneous leishmaniasis, american, is related to leishmaniasis and cutaneous leishmaniasis. An important gene associated with Mucocutaneous Leishmaniasis is IFNG (interferon, gamma), and among its related pathways are Calcium signaling in the CD4+ TCR pathway and Downstream signaling in naive CD8+ T cells. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin.

Aliases & Classifications for Mucocutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

mucocutaneous leishmaniasis 8 10 60
mucocutaneous leishmaniasis, american 8
american mucocutaneous leishmaniasis 8
new world cutaneous leishmaniasis 8
cutaneous leishmaniasis, american 8
american cutaneous leishmaniasis 8
mucocutaneous leishmaniasis, 8


External Ids:

Disease Ontology8 DOID:9155
ICD9CM27 085.4, 085.5
MeSH34 D007897
NCIt39 C34769
ICD1025 B55.2

Related Diseases for Mucocutaneous Leishmaniasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to mucocutaneous leishmaniasis

Clinical Features for Mucocutaneous Leishmaniasis

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Drugs & Therapeutics for Mucocutaneous Leishmaniasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Mucocutaneous Leishmaniasis

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Genetic Tests for Mucocutaneous Leishmaniasis

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Anatomical Context for Mucocutaneous Leishmaniasis

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32MalaCards
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MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

32
Testes, T cells, Skin, Monocytes

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

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Publications for Mucocutaneous Leishmaniasis

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50PubMed
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Articles related to Mucocutaneous Leishmaniasis:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)
2013
2
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. (23867693)
2013
3
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)
2012
4
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. (21739015)
2011
5
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
6
Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. (20375822)
2010
7
A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. (20465699)
2010
8
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. (20377337)
2010
9
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
10
Interventions for American cutaneous and mucocutaneous leishmaniasis. (19370612)
2009
11
The value of the otorhinolaryngologic exam in correct mucocutaneous leishmaniasis diagnosis. (19706900)
2009
12
Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)
2008
13
Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)
2008
14
A case of mucocutaneous leishmaniasis. (15886638)
2005
15
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)
2004
16
Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)
2004
17
Ocular alterations in patients with cutaneous and mucocutaneous leishmaniasis. (12680552)
2003
18
Epidemiological and clinical features of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in the State of EspA-rito Santo, Brazil. (15049080)
2003
19
Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)
2001
20
Mucocutaneous leishmaniasis in a patient with the human immunodeficiency virus. (11564337)
2001
21
Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)
1999
22
Polymerase chain reaction reveals Trypanosoma cruzi infection suspected by serology in cutaneous and mucocutaneous leishmaniasis patients. (10232785)
1999
23
Risk factors for onset of cutaneous and mucocutaneous leishmaniasis in Bolivia. (9242324)
1997
24
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)
1995
25
Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)
1995
26
T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis. (7496967)
1994
27
Mucocutaneous leishmaniasis and HIV. (7949483)
1994
28
Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)
1993
29
Fifteen years of cutaneous and mucocutaneous leishmaniasis in Bolivia: a retrospective study. (8465401)
1993
30
Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol. (1566297)
1992
31
Quantitative study of Leishmania braziliensis braziliensis reactive T cells in peripheral blood and in the lesions of patients with American mucocutaneous leishmaniasis. (2311299)
1990
32
Mucocutaneous leishmaniasis. (2224223)
1990
33
Evaluation of serological diagnostic indices for mucocutaneous leishmaniasis: immunofluorescence tests and enzyme-linked immunoassays for IgG, IgM and IgA antibodies. (2699277)
1989
34
Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)
1988
35
Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis). (2687621)
1988
36
Identification and purification of a 72 kDa antigen of Leishmania braziliensis braziliensis present on the surface and in the cytoplasm of the promastigotes and its specific recognition by sera from mucocutaneous leishmaniasis patients. (3253506)
1988
37
Evaluation of dot enzyme-linked immunosorbent assay for mucocutaneous leishmaniasis and comparison with microplate enzyme immunoassay. (3531227)
1986
38
Multivariate discrimination between Lutzomyia wellcomei, a vector of mucocutaneous leishmaniasis, and Lu. complexus (Diptera: Phlebotominae). (4073999)
1985
39
Identification of human stocks of Leishmania spp. isolated from patients with mucocutaneous leishmaniasis in TrA-s BraAsos, Bahia, Brazil. (6506171)
1984
40
Anti-leishmania IgA immunoenzymatic assay in mucocutaneous leishmaniasis (preliminary report). (6398906)
1984
41
Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)
1983
42
Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)
1981
43
A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)
1980
44
Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. (434070)
1979
45
Borderline cutaneous leishmaniasis. Clinical, immunological and histological differences from mucocutaneous leishmaniasis. (418492)
1978
46
Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)
1977
47
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975
48
Mucocutaneous leishmaniasis in guinea-pigs inoculated intravenously with Leishmania enriettii. Preliminary report. (1182080)
1975
49
The treatment of American (mucocutaneous) leishmaniasis with amphotericin B. (13745957)
1960
50
Visceral manifestations of American mucocutaneous leishmaniasis. (13282931)
1956

Genetic Variations for Mucocutaneous Leishmaniasis

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Expression for genes affiliated with Mucocutaneous Leishmaniasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucocutaneous Leishmaniasis

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Pathways for genes affiliated with Mucocutaneous Leishmaniasis

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37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 53Reactome, 51QIAGEN
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Compounds for genes affiliated with Mucocutaneous Leishmaniasis

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.0TNF, IFNG
2vesnarinone4410.0TNF, IFNG
3taurine chloramine4410.0TNF, IFNG
4gold sodium thiomalate4410.0TNF, IFNG
5natalizumab44 1111.0IFNG, TNF
6adalimumab44 49 1112.0TNF, IFNG
7il-124410.0TNF, IFNG
8staurosporin4410.0IFNG, TNF
9indoleamine4410.0IFNG, TNF
10imiquimod44 28 59 1113.0TNF, IFNG
11polymyxin b4410.0TNF, IFNG
12okt3449.9IFNG, TNF
13gm-csf44 2810.9TNF, IFNG
14triptolide449.9TNF, IFNG
15budesonide44 49 1111.9IFNG, TNF
16parthenolide44 210.9IFNG, TNF
17fluticasone propionate44 49 59 1112.9TNF, IFNG
182,5-oligoadenylate449.9TNF, IFNG
19polyinosinic-polycytidylic acid449.9TNF, IFNG
20etanercept44 49 1111.9IFNG, TNF
21poly(i-c)449.9TNF, IFNG
22il 10449.8TNF, IFNG
23l-nmma449.8IFNG, TNF
24infliximab44 49 1111.8IFNG, TNF
25glucosamine44 11 2411.8TNF, IFNG
26tarc449.7TNF, IFNG
27Inosinic Acid11 2410.7ENTPD3, ENTPD8
28inosine triphosphate44 2410.7ENTPD3, ENTPD8
29ivig449.7TNF, IFNG
30ccl344 2810.6IFNG, TNF
3115-deoxy-delta-12,14-prostaglandin j2449.6TNF, IFNG
32melphalan44 1110.5TNF, IFNG
33neopterin449.3TNF, IFNG

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

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16Gene Ontology
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Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.8IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.7TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNF
7protein import into nucleus, translocationGO:0000609.6TNF, IFNG
8humoral immune responseGO:0069599.6TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
10positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoside-triphosphatase activityGO:0171119.3ENTPD8, ENTPD3
2nucleoside-diphosphatase activityGO:0171109.0ENTPD8, ENTPD3

Products for genes affiliated with Mucocutaneous Leishmaniasis

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Sources for Mucocutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet