Mucocutaneous Leishmaniasis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Disease Ontology:¹⁰ A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary: Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and pituitary apoplexy. An important gene associated with Mucocutaneous Leishmaniasis is CD4 (CD4 Molecule), and among its related pathways are Primary immunodeficiency and IL-10 Pathway. Affiliated tissues include prostate, breast and spinal cord, and related mouse phenotypes are integument and endocrine/exocrine gland.

Related Diseases for Mucocutaneous Leishmaniasis

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)

id	Related Disease	Score	Top Affiliating Genes
1	leishmaniasis	11.3
2	pituitary apoplexy	10.6	CD4, CD8A
3	hyperhomocysteinemia	10.6	CD4, CD8A
4	malignant cornea melanoma	10.6	CD4, CD8A
5	acute cystitis	10.6	CD4, CD8A
6	cd3epsilon deficiency	10.6	CD4, CD8A
7	mycotic corneal ulcer	10.6	CD4, CD8A
8	monkeypox	10.6	CD4, CD8A
9	neurotic disorder	10.6	CD4, IL10
10	rem sleep behavior disorder	10.6	CD4, CD8A
11	toxic maculopathy	10.6	CD4, CD8A
12	coronin-1a deficiency	10.6	CD4, CD8A
13	leukocyte disease	10.6	CD4, CD8A
14	desquamative interstitial pneumonia	10.6	CD4, CD8A
15	microsporidiosis	10.6	CD4, CD8A
16	late congenital syphilis	10.6	CD4, CD8A
17	lichen disease	10.6	CD4, CD8A
18	pityriasis rosea	10.6	CD4, CD8A
19	enophthalmos	10.6	CD4, CD8A
20	inflammatory leiomyosarcoma	10.6	CD4, CD8A
21	myositis ossificans	10.6	CD4, CD8A
22	juvenile spinal muscular atrophy	10.6	CD4, CD8A
23	hyperinsulinism	10.6	CD4, CD8A
24	rhabdoid cancer	10.6	CD4, CD8A
25	paralytic squint	10.6	CD4, CD8A
26	pharyngoconjunctival fever	10.6	CD4, CD8A
27	vein disease	10.6	CD4, CD8A
28	arcus senilis	10.6	CD4, CD8A
29	rheumatic myocarditis	10.6	CD4, IL4
30	autoimmune disease of cardiovascular system	10.6	CD4, CD8A
31	status asthmaticus	10.6	CD4, IL4
32	cervical incompetence	10.5	CD4, CD8A
33	cycloplegia	10.5	IL10, IL4
34	eosinophilic gastroenteritis	10.5	CD4, IL4
35	internal hordeolum	10.5	CD4, CD8A
36	extrapulmonary tuberculosis	10.5	CD4, IL4
37	mobitz type ii atrioventricular block	10.5	CD4, IL4
38	interleukin-7 receptor alpha deficiency	10.5	CD4, CD8A
39	dioctophymiasis	10.5	IL10, IL4
40	female breast central part cancer	10.5	CD4, CD8A
41	penicillin allergy	10.5	IL10, IL4
42	superficial urinary bladder cancer	10.5	IL10, IL4
43	neurofibromatosis	10.5	CD4, IL4
44	buruli ulcer	10.5	IL10, IL4
45	nemaline myopathy	10.5	CD4, CD8A
46	clivus chordoma	10.5	CD4, CD8A
47	parathyroid gland disease	10.5	CD4, CD8A
48	ethmoid sinus squamous cell carcinoma	10.5	CD4, TNF
49	cow milk allergy	10.5	IL10, IL4
50	relapsing polychondritis	10.5	CD4, CD8A

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:

Symptoms for Mucocutaneous Leishmaniasis

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Anti-Infective Agents

Phase 2, Phase 3, Phase 1

17220

2

Antiprotozoal Agents

Phase 2, Phase 3, Phase 1

1730

3

meglumine antimoniate

Phase 2, Phase 3

25

4

Antiparasitic Agents

Phase 2, Phase 3, Phase 1

1854

5

Miconazole

approved, investigational

Phase 2, Phase 1

3026

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

AKOS001574474

Aflorix(nitrate)

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

CPD-4501

Conofite(nitrate)

D00416

DB01110

Dactarin

Daktarin IV

Daktarin iv

Desenex

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

LS-78378

Lotrimin AF(nitrate)

MCZ

MJR 1762

MLS002222203

Makesense

Micantin (nitrate)

Micatin

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

Miconazole

Miconazole (JP15/USP/INN)

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole [USAN:BAN:INN:JAN]

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (TN)

Monistat iv (tn)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

NSC 170986

NSC169434

NSC170986

Novo-Miconazole Vaginal Ovules

Oprea1_091955

Oravig

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

Prestwick_335

R 18134

R-14,889

Rash Relief Antifungal

SMR001307249

SPBio_000976

SPBio_002174

STK834405

STOCK1S-93556

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

Spectrum_000965

UNII-7NNO0D7S5M

Vusion

Zimycan

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

miconazole

6

Amphotericin B

approved, investigational

Phase 2, Phase 1

117

1397-89-3

14956, 5280965

Synonyms:

12633-72-6

1397-89-3

30782-62-8

5-18-10-00525 (Beilstein Handbook Reference)

54482-28-9

8055-20-7

AB00513832

ABLC

AC1L1CN2

AC1L24V6

AC1L70KF

AC1L73U6

AC1NQXTD

AC1NTQ32

AC1NUQG4

AC1NY9JC

AC1O7GCZ

AC1O8FQV

AC1O8PFK

AI3-26528

AMPH-B

AMPH-b

Abelcet

Abelecet

AmBisome (TN)

Ambap1397-89-3

Ambisome

Amfotericina B

Amfotericina B [INN-Spanish]

Ampho-Moronal

Amphocin

Amphomoronal

Amphortericin B

Amphotec

Amphotec (TN)

Amphotericin

Amphotericin .BETA.

Amphotericin B

Amphotericin B (JP15/USP/INN)

Amphotericin B Cholesterol Dispersion

Amphotericin B Cholesteryl Sulfate Complex

Amphotericin B Colloidal Dispersion

Amphotericin B [USAN:INN:JAN]

Amphotericin B, Lipid-based

Amphotericin B, Streptomyces sp.

Amphotericin-B

Amphotericine B

Amphotericine B [INN-French]

Amphotericinum

Amphotericinum B

Amphotericinum B [INN-Latin]

Amphotherizin

Amphotherizin [German]

Amphotéricine B

Amphozone

BIDD:GT0351

BPBio1_000374

BRN 0078342

BSPBio_000340

C-AmB

C06573

C47H73NO17

CCRIS 5963

CHEBI:2682

CHEMBL1200646

CHEMBL267345

CID10533925

CID10629638

CID10677275

CID14956

CID1972

CID352546

CID354192

CID5280965

CID5386092

CID5458486

CID5771695

CID6604295

CID6708817

CID6713692

CID9919339

D00203

DB00681

DivK1c_007045

EINECS 215-742-2

Fungilin

Fungisome

Fungisone

Fungizone

Fungizone (TN)

HMS1569A22

HSDB 3008

HSDB 3008 IAB

Halizon

I06-0257

KBio1_001989

KBio2_000551

KBio2_003119

KBio2_005687

KBioGR_002298

KBioSS_000551

LMPK06000002

LNS-AmB

LS-187721

LS-93

Liposomal Amphotericin B

Liposomal amphotericin b

MLS002702966

MolPort-006-392-260

Mysteclin-F

NCGC00014913

NCGC00090808-01

NCGC00098014-01

NCGC00179595-01

NCI527017

NCI60_004288

NCIStruc1_001042

NCIStruc2_000920

NKTR-024

NS 718

NSC 527017

NSC-527017

NSC527017

Prestwick0_000410

Prestwick1_000410

Prestwick2_000410

Prestwick3_000410

Prestwick_721

SMP1_000302

SMR001566780

SPBio_000715

SPBio_002279

ST50999656

SinuNase

SpecPlus_000949

Spectrum2_000818

Spectrum4_001779

Spectrum_000111

UNII-7XU7A7DROE

amophotericin B

amphotericin B liposomal

amphotericin b

7

Miltefosine

approved

Phase 2, Phase 1

33

58066-85-6

3600

Synonyms:

1-Hexadecylphosphorylcholine

2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt

3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide

4-04-00-01460 (Beilstein Handbook Reference)

58066-85-6

AC1L1GAH

BRN 3690495

Baxter Oncology brand of miltefosine

Baxter brand of miltefosine

C039128

C15H32.C7H17NO4P

CHEBI:125047

CHEMBL125

CID3599

Choline hydroxide, hexadecyl hydrogen phosphate, inner salt

Choline phosphate, hexadecyl ester, hydroxide, inner salt

Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI)

Choline, hexadecyl hydrogen phosphate, inner salt

D 18506

D-18506

D02494

D18506

Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt

Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt

H-1850

HDPC

HMS1922D16

HMS2089J15

HePC

Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate

Hexadecylphosphocholine

Hexadecylphosphorylcholine

I14-7244

IN1227

Impavido

LS-65132

M-7200

Miltefosin

Miltefosin C

Miltefosina

Miltefosina [INN-Spanish]

Miltefosine

Miltefosine (INN)

Miltefosine [INN:BAN]

Miltefosinum

Miltefosinum [INN-Latin]

Miltex

Miltéfosine

MolPort-003-665-519

Monohexadecylphosphocholine

Monohexadecylphosphorylcholine

NCGC00095169-01

NCGC00095169-02

NCGC00095169-03

NSC605583

Prasfarma brand of miltefosine

SPECTRUM1505329

ST51055612

TF-002

UNII-53EY29W7EC

hexadecyl 2-(trimethylazaniumyl)ethyl phosphate

n-Hexadecylphosphorylcholine

8

Pentoxifylline

approved, investigational

Phase 2

90

6493-05-6

4740

Synonyms:

1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion

1-(5-Oxohexyl)-3,7-dimethylxanthine

1-(5-Oxohexyl)theobromine

2a3c

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl) xantine

3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione

3,7-Dimethyl-1-(5-oxohexyl)xanthine

3,7-Dimethyl-1-(5-oxohexyl)xantine

3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

5-26-14-00081 (Beilstein Handbook Reference)

6493-05-6

AB00052363

AC1L1IUN

AKOS000541484

Agapurin

Agapurin Retard

Azupentat

BAS 00897429

BB_SC-2111

BIDD:GT0174

BL 191

BL-191

BL191

BPBio1_000167

BRD-K57569181-001-05-1

BRN 0558929

BSPBio_000151

BSPBio_003439

C07424

C13H18N4O3

CAS-1677687

CCRIS 6832

CHEMBL628

CID4740

CPD000035998

D00501

D010431

DB00806

Dimethyloxohexylxanthine

DivK1c_000729

Durapental

EHT 0201

EHT-0201

EHT-201

EHT0201

EINECS 229-374-5

EU-0100936

HMS1568H13

HMS1922E16

HMS2051N06

HMS2090H13

HMS2093G21

HMS502E11

Hemovas

I06-1592

IDI1_000729

IN1161

Ikomio

KBio1_000729

KBio2_001924

KBio2_004492

KBio2_007060

KBio3_002942

KBioGR_000893

KBioSS_001924

LS-149385

Lopac-P-1784

Lopac0_000936

MLS000079026

MLS000758298

MLS001201764

MolPort-001-823-263

NCGC00015801-01

NCGC00015801-02

NCGC00015801-04

NCGC00015801-10

NCGC00067069-02

NCGC00067069-03

NCGC00067069-04

NCGC00067069-05

NCGC00178062-01

NCGC00178062-02

NINDS_000729

NSC 637086

NSC637086

Oxpentifylline

P 1784

PDSP1_001015

PDSP2_000999

PENTOXYPHYLINE

PNX

Pentoxifilina

Pentoxifilina [INN-Spanish]

Pentoxifyllin

Pentoxifylline

Pentoxifylline (JAN/USP/INN)

Pentoxifylline [USAN:INN:JAN]

Pentoxifyllinum

Pentoxifyllinum [INN-Latin]

Pentoxil

Pentoxil (TN)

Pentoxiphyllin

Pentoxiphylline

Pentoxiphyllium

Pentoxyfylline

Pentoxyphyllin

Pentoxyphylline

Prestwick0_000196

Prestwick1_000196

Prestwick2_000196

Prestwick3_000196

Prestwick_608

Px

Ralofect

Rentylin

SAM001247011

SMR000035998

SPBio_001221

SPBio_002072

SPECTRUM1503611

SR-01000075641-4

STK177321

Spectrum2_001181

Spectrum3_001820

Spectrum4_000227

Spectrum5_001161

Spectrum_001444

Torental

Trental

Trental (TN)

UNII-SD6QCT3TSU

Vasofirin

Vazofirin

ZINC01530776

cis-9-Octadecenoyl coenzyme A

pentoxifylline

9

Liposomal amphotericin B

Phase 2, Phase 1

117

10

Antimony Sodium Gluconate

Phase 2, Phase 1

15

11

Antifungal Agents

Phase 2, Phase 1

3015

12

Anthelmintics

Phase 2, Phase 1

379

13

Coal Tar

Phase 2

165

14

Radiation-Protective Agents

Phase 2

333

15

Vasodilator Agents

Phase 2

2926

16

Protective Agents

Phase 2

5651

17

Platelet Aggregation Inhibitors

Phase 2

1935

18

Phosphodiesterase Inhibitors

Phase 2

1062

19

Antioxidants

Phase 2

2442

20

Vaccines

Phase 1

6085

21

Immunologic Factors

Phase 1

18483

Interventional clinical trials:

(show all 14)

id	Name	Status	NCT ID	Phase
1	Low Antimonial Dosage in American Mucosal Leishmaniasis	Recruiting	NCT01301937	Phase 2, Phase 3
2	Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis	Completed	NCT01377974	Phase 2
3	Miltefosine to Treat Mucocutaneous Leishmaniasis	Completed	NCT01050907	Phase 2
4	Miltefosine for Mucosal Leishmaniasis	Completed	NCT00373776	Phase 1, Phase 2
5	Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis	Completed	NCT00373568	Phase 1, Phase 2
6	Sodium Stibogluconate Treatment of Leishmaniasis	Completed	NCT00662012	Phase 2
7	Miltefosine to Treat Cutaneous Leishmaniasis in Bolivia	Completed	NCT00233545	Phase 2
8	The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil	Recruiting	NCT02530697	Phase 2
9	Use of Sodium Stibogluconate as a Treatment for Leishmaniasis	Enrolling by invitation	NCT00657618	Phase 1, Phase 2
10	Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis	Completed	NCT00111514	Phase 1
11	Diagnosis and Treatment of Leishmanial Infections	Recruiting	NCT00344188
12	Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis	Available	NCT00508963
13	Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Not yet recruiting	NCT02429518
14	Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Not yet recruiting	NCT02431429

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

³³

Prostate, Breast, Spinal cord, Liver, Heart, T cells, Endothelial

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	8.7	CD4, CD8A, IL10, IL4, TNF
2	endocrine/exocrine gland	MP:0005379	7.9	CD4, CD8A, IL10, IL4, LTA, TNF
3	vision/eye	MP:0005391	7.4	IL10, IL4, LTA, NID1, SCYL1, TNF
4	mortality/aging	MP:0010768	6.9	CD4, CD8A, IL10, IL4, LTA, SCYL1
5	hematopoietic system	MP:0005397	6.9	CD4, CD8A, IL10, IL4, LTA, SCYL1
6	immune system	MP:0005387	6.6	CD4, CD8A, IL10, IL4, LTA, SCYL1
7	nervous system	MP:0003631	6.6	CD4, CD8A, IL10, IL4, LTA, NID1

Publications for Mucocutaneous Leishmaniasis

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 142)

id	Title	Authors	Year
1	Mucocutaneous leishmaniasis. (26994882)	Novoa Juiz V.... Redondo LuciaA+ez R.	2016
2	Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. (26568336)	Handler M.Z.... Schwartz R.A.	2015
3	Mucocutaneous leishmaniasis of the nose: a case report. (26513953)	Menten K.... Lemkens P.	2015
4	Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. (26568335)	Handler M.Z.... Schwartz R.A.	2015
5	Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. (25442251)	Crovetto-MartA-nez R.... Crovetto-De la Torre M.A.	2015
6	A case of mucocutaneous leishmaniasis diagnosed by serology. (25041360)	Okumura Y.... Seishima M.	2014
7	Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)	Reveiz L.... Yadon Z.E.	2013
8	Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. (23690792)	Ruoti M.... Krentel A.	2013
9	Cutaneous and mucocutaneous leishmaniasis. (22632640)	Goto H.... Lauletta Lindoso J.A.	2012
10	Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. (22819605)	Fraga J.... Van der Auwera G.	2012
11	Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)	Dorlo T.P.... Kager P.A.	2010
12	Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)	Padovese V.... Morrone A.	2009
13	Successful diagnosis and treatment 50 years after exposure: is mucocutaneous leishmaniasis still a neglected differential diagnosis? (19090806)	Schleucher R.D.... Knobloch J.	2008
14	Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis. (19082374)	Nogueira M.F.... CucAc L.C.	2008
15	Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis. (17360886)	Nolder D.... Miles M.A.	2007
16	Parenteral aminosidine is not effective for Peruvian mucocutaneous leishmaniasis. (17556623)	Llanos-Cuentas A.... Bryceson A.	2007
17	Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. (16991092)	Acestor N.... Fasel N.	2006
18	Mucocutaneous leishmaniasis: report of a case with massive involvement of nasal, pharyngeal and laryngeal mucosa. (16574379)	Di Lella F.... Di Lella G.	2006
19	A case of mucocutaneous leishmaniasis. (15886638)	Virgilio G.R.... Hale B.R.	2005
20	Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America. (15472268)	Ahluwalia S.... Lockwood D.N.	2004
21	Itraconazole in the treatment of New World mucocutaneous leishmaniasis. (15357745)	Calvopina M.... Cooper P.J.	2004
22	Disseminated mucocutaneous leishmaniasis resulting from chronic use of corticosteroid. (12956682)	Motta A.C.... Foss N.T.	2003
23	A case of mucocutaneous leishmaniasis. (11816390)	Galioto P.... Fornaro V.	2002
24	Chronic dacryocystitis in American mucocutaneous leishmaniasis. (11206745)	Baddini-Caramelli C.... Kara-JosAc N.	2001
25	Tumour necrosis factor alpha and mucocutaneous leishmaniasis. (10234190)	Blackwell J.M.	1999
26	Cutaneous and mucocutaneous leishmaniasis. (8620680)	Samady J.A.... Schwartz R.A.	1996
27	Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. (7595196)	Cabrera M.... Blackwell J.M.	1995
28	Rural campaign to diagnose and treat mucocutaneous leishmaniasis in Bolivia. (7614666)	Dedet J.P.... Villareal M.E.	1995
29	Clinical healing of antimony-resistant cutaneous or mucocutaneous leishmaniasis following the combined administration of interferon-gamma and pentavalent antimonial compounds. (8154019)	Falcoff E.... BernabA^ J.G.	1994
30	American mucocutaneous leishmaniasis. (7805299)	Goihman-Yahr M.	1994
31	Mucocutaneous leishmaniasis: a clinicopathologic classification. (8496456)	Sangueza O.P.... Sangueza P.	1993
32	American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. (1492379)	Escobar M.A.... Palma G.I.	1992
33	Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. (1842401)	Bittencourt A.L.... Barral A.	1991
34	Prevalence of mucocutaneous leishmaniasis in littoral Bahia, Brazil. (2389315)	Lago L.... Marsden P.D.	1990
35	Histological analysis and the pathogenesis of mucocutaneous leishmaniasis. (2614573)	Ridley D.S.... Marsden P.D.	1989
36	Evaluation of a skin test on the canine mucocutaneous leishmaniasis diagnosis. (3078346)	Marzochi M.C.... Barbosa-Santos E.G.	1988
37	Frequency of Leishmania-reactive T cells in lesions of American mucocutaneous leishmaniasis (AMCL) patients. Its relevance in the process of healing or aggravation of the disease. (3267032)	ConceiAsALo-Silva F.... Coutinho S.G.	1988
38	Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. (4025684)	Saravia N.G.... D'Alessandro A.	1985
39	Specific IgE antibodies to Leishmania braziliensis in patients with mucocutaneous leishmaniasis. (6625531)	Afchain D.... Capron A.	1983
40	A simple method for the collection of material from cutaneous and mucocutaneous leishmaniasis lesions. (6665854)	Urjel R.... Orellana H.	1983
41	Further trials of nifurtimox in mucocutaneous leishmaniasis. (7324099)	Guerra M.F.... Barretto A.C.	1981
42	Immunoenzymatic assy (ELISA) in mucocutaneous leishmaniasis, kala-azar, and Chagas' disease: an epimastigote Trypanosoma cruzi antigen able to distinguish between anti-Trypanosoma and anti-Leishmania antibodies. (6792937)	GuimarALes M.C.... Diniz J.M.	1981
43	The practical importance of culturing Leishmania isolated from patients with cutaneous or mucocutaneous leishmaniasis. (7324141)	Marinkelle C.J.	1981
44	A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation. (7445048)	Ridley D.S.... Barreto A.C.	1980
45	Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)	Belehu A.... Touw-Langendijk E.	1978
46	Mucocutaneous leishmaniasis--an unsolved clinical problem. (841692)	Marsden P.D.... Radke M.	1977
47	Use of amphotericin B in mucocutaneous leishmaniasis. (933229)	Crofts M.A.	1976
48	Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)	Shaw J.J.... Lainson R.	1975
49	Antigenic standardization for mucocutaneous leishmaniasis immunofluorescence test. (4608167)	GuimarALes M.C.... Camargo M.E.	1974
50	THE HUMAN TRYPANOSOMATIDAE. IV. CUTANEOUS AND MUCOCUTANEOUS LEISHMANIASIS. (14083450)	Cahill K.M.	1963

Genes related to Mucocutaneous Leishmaniasis

Sources:
²⁰GeneCards, ¹²DISEASES
See all MalaCards sources

Genes related to Mucocutaneous Leishmaniasis:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	CD4	CD4 Molecule	15.81	DISEASES inferred ¹²
2	IL10	Interleukin 10	15.49	DISEASES inferred ¹²
3	CD8A	CD8a Molecule	15.25	DISEASES inferred ¹²
4	IL4	Interleukin 4	15.20	DISEASES inferred ¹²
5	NID1	Nidogen 1	14.96	DISEASES inferred ¹²
6	SCYL1	SCY1 Like Pseudokinase 1	14.95	DISEASES inferred ¹²
7	LTA	Lymphotoxin Alpha	14.82	DISEASES inferred ¹²
8	TNF	Tumor Necrosis Factor	14.80	DISEASES inferred ¹²

Variations for Mucocutaneous Leishmaniasis

Expression for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
⁵²PathCards, ³¹KEGG, ⁵⁵QIAGEN, ⁵⁶R&D Systems, ³⁹NCBI BioSystems Database, ⁶²Thomson Reuters, ⁵⁷Reactome
See all MalaCards sources

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 22)

id	Super pathways	Score	Top Affiliating Genes
1	Primary immunodeficiency³¹	9.7	CD4, CD8A
2	IL-10 Pathway⁵⁵	9.6	IL10, TNF
3	African trypanosomiasis³¹	9.6	IL10, TNF
4	IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁶ Show member pathways IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁶	9.6	IL10, TNF
5	Th2 Differentiation Pathway⁵⁶	9.3	CD4, IL10, IL4
6	IL12-mediated signaling events³⁹ Show member pathways Immune response IL-12-induced IFN-gamma production⁶²	9.3	CD4, CD8A, IL4
7	Immune response IL-23 signaling pathway⁶² Show member pathways Development PDGF signaling via STATs and NF-kB⁶² Immune response IL-10 signaling pathway⁶² Development Angiopoietin - Tie2 signaling⁶² Angiopoietin-TIE2 Signaling⁵⁵ Angiopoietin receptor Tie2-mediated signaling³⁹ IL23-mediated signaling events³⁹	9.2	CD4, IL10, TNF
8	Toxoplasmosis³¹ Show member pathways Leishmaniasis³¹	9.1	IL10, IL4, TNF
9	Dendritic Cells Developmental Lineage Pathway⁵⁶	8.8	CD4, CD8A, IL10, TNF
10	OX40 Pathway⁵⁵	8.8	IL10, IL4, LTA
11	IL4-mediated signaling events³⁹	8.8	IL10, IL4, LTA
12	Cytokines and Inflammatory Response³⁹	8.8	CD4, IL10, IL4, TNF
13	Hematopoietic cell lineage³¹	8.7	CD4, CD8A, IL4, TNF
14	IL27-mediated signaling events³⁹ Show member pathways Th1 Differentiation Pathway⁵⁶ IL-12 Family Signaling Pathways⁵⁶	8.4	CD4, IL10, LTA, TNF
15	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	8.4	CD4, CD8A, IL10, IL4, TNF
16	B cell receptor signaling pathway (KEGG)³¹ Show member pathways B cell receptor signaling pathway³¹ T cell receptor signaling pathway³¹ TCR Signaling Pathway³⁹ BCR signaling pathway³⁹	8.4	CD4, CD8A, IL10, IL4, TNF
17	Immune response IFN alpha/beta signaling pathway⁶² Show member pathways Interferon alpha/beta signaling⁵⁷ Cytokine Network⁵⁵ Regulation of IFNA signaling⁵⁷	8.3	IL10, IL4, LTA, TNF
18	IgA-Producing B Cells in the Intestine⁵⁶	8.3	IL10, IL4, LTA, TNF
19	Akt Signaling⁵⁵ Show member pathways Tec Kinases Signaling⁵⁵ p38 Signaling⁵⁵	8.0	CD4, IL10, IL4, LTA, TNF
20	PAK Pathway⁵⁵ Show member pathways Epithelial Adherens Junctions⁵⁵ Antioxidant Action of Vitamin-C⁵⁵	8.0	CD4, IL10, IL4, LTA, TNF
21	Innate Lymphoid Cell Differentiation Pathways⁵⁶	7.5	CD4, CD8A, IL10, IL4, LTA, TNF
22	Allograft rejection³⁹ ³¹ Show member pathways Antigen processing and presentation³¹ Viral myocarditis³¹ Intestinal immune network for IgA production³¹ CTL Mediated Apoptosis⁵⁵ THC Differentiation Pathway⁵⁵ Allograft Rejection³⁹ Asthma³¹ Autoimmune thyroid disease³¹ Type I diabetes mellitus³¹ Graft-versus-host disease³¹ Inflammatory bowel disease (IBD)³¹	7.5	CD4, CD8A, IL10, IL4, LTA, TNF

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	defense response to protozoan	GO:0042832	10.2	IL10, IL4
2	receptor biosynthetic process	GO:0032800	10.2	IL10, TNF
3	type 2 immune response	GO:0042092	10.2	IL10, IL4
4	B cell differentiation	GO:0030183	10.2	IL10, IL4
5	negative regulation of cytokine secretion involved in immune response	GO:0002740	10.2	IL10, TNF
6	positive regulation of mononuclear cell migration	GO:0071677	10.1	IL4, TNF
7	positive regulation of chemokine biosynthetic process	GO:0045080	10.1	IL4, TNF
8	negative regulation of endothelial cell apoptotic process	GO:2000352	10.1	IL10, IL4
9	negative regulation of growth of symbiont in host	GO:0044130	10.1	IL10, TNF
10	negative regulation of nitric oxide biosynthetic process	GO:0045019	10.1	IL10, IL4
11	negative regulation of interleukin-6 production	GO:0032715	10.0	IL10, TNF
12	positive regulation of MHC class II biosynthetic process	GO:0045348	10.0	IL10, IL4
13	positive regulation of calcium-mediated signaling	GO:0050850	10.0	CD4, CD8A
14	positive regulation of chronic inflammatory response to antigenic stimulus	GO:0002876	9.7	LTA, TNF
15	response to organic substance	GO:0010033	9.6	IL10, TNF
16	positive regulation of interferon-gamma production	GO:0032729	9.5	LTA, TNF
17	positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091	9.5	IL10, IL4, TNF
18	T cell activation	GO:0042110	9.4	CD4, CD8A
19	response to drug	GO:0042493	8.9	IL10, IL4, LTA
20	immune response	GO:0006955	8.8	CD4, IL10, IL4, TNF

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	9.7	CD4, CD8A

Sources for Mucocutaneous Leishmaniasis

¹BitterDB

²CDC

³Cell Signaling Technology

⁴ClinicalTrials

⁵Clinvar

⁶Cochrane Library

⁷Cosmic

⁸dbSNP

⁹DGIdb

¹⁰Disease Ontology

¹¹diseasecard

¹²DISEASES

¹³DrugBank

¹⁴ExPASy

¹⁵FDA

¹⁶FMA

¹⁷Gene Expression Omnibus DataSets

¹⁸Gene Ontology

¹⁹GeneAnalytics

²⁰GeneCards

²¹GeneReviews

²²GeneTests

²³Genetics Home Reference

²⁴GTR

²⁵HGMD

²⁶HMDB

²⁷ICD10

²⁸ICD10 via Orphanet

²⁹ICD9CM

³⁰IUPHAR

³¹KEGG

³²LifeMap Discovery®

³³MalaCards

³⁴MedGen

³⁵MedlinePlus

³⁶MeSH

³⁷MESH via Orphanet

³⁸MGI

³⁹NCBI BioSystems Database

⁴⁰NCBI Bookshelf

⁴¹NCI

⁴²NCIt

⁴³NDF-RT

⁴⁴NIH Clinical Center

⁴⁵NIH Rare Diseases

⁴⁶NINDS

⁴⁷Novoseek

⁴⁸Novus Biologicals

⁴⁹OMIM

⁵⁰OMIM via Orphanet

⁵¹Orphanet

⁵²PathCards

⁵³PharmGKB

⁵⁴PubMed

⁵⁵QIAGEN

⁵⁶R&D Systems

⁵⁷Reactome

⁵⁸SinoBiological

⁵⁹SNOMED-CT

⁶⁰SNOMED-CT via Orphanet

⁶¹The Human Phenotype Ontology

⁶²Thomson Reuters

⁶³Tocris Bioscience

⁶⁴Tumor Gene Family of Databases

⁶⁵UMLS

⁶⁶UMLS via Orphanet

⁶⁷UniProtKB/Swiss-Prot

⁶⁸Wikipedia

MCID: MCC002 MIFTS: 50	Mucocutaneous Leishmaniasis malady Category: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs Download this MalaCard Expand all tables

Mucocutaneous Leishmaniasis malady

Aliases & Classifications for Mucocutaneous Leishmaniasis

Aliases & Descriptions for Mucocutaneous Leishmaniasis:

Classifications:

External Ids:

Summaries for Mucocutaneous Leishmaniasis

Related Diseases for Mucocutaneous Leishmaniasis

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:

Symptoms for Mucocutaneous Leishmaniasis

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

Animal Models for Mucocutaneous Leishmaniasis or affiliated genes

MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis:

Publications for Mucocutaneous Leishmaniasis

Articles related to Mucocutaneous Leishmaniasis:

Genes related to Mucocutaneous Leishmaniasis

Genes related to Mucocutaneous Leishmaniasis:

Variations for Mucocutaneous Leishmaniasis

Expression for genes affiliated with Mucocutaneous Leishmaniasis

Pathways for genes affiliated with Mucocutaneous Leishmaniasis

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

GO Terms for genes affiliated with Mucocutaneous Leishmaniasis

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

Molecular functions related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

Sources for Mucocutaneous Leishmaniasis