MEC
MCID: MCP006
MIFTS: 48

Mucoepidermoid Carcinoma (MEC) malady

Cancer diseases category

Summaries for Mucoepidermoid Carcinoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  the earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  treatment often begins with surgery to remove the entire tumor.  in some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. last updated: 6/18/2013

MalaCards: Mucoepidermoid Carcinoma, also known as carcinoma mucoepidermoid, is related to adenoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Mucoepidermoid Carcinoma is FOXE1 (forkhead box E1 (thyroid transcription factor 2)). The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung.

Disease Ontology:8 A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia:63 Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid... more...

Aliases & Classifications for Mucoepidermoid Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mucoepidermoid carcinoma 8 42 10 60
carcinoma mucoepidermoid 44
mec 8


External Ids:

Disease Ontology8 DOID:4531
MeSH34 D018277
SNOMED-CT56 4079000
NCIt39 C3772

Related Diseases for Mucoepidermoid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8S100A1, AREG, MUC2, CLDN3, KRT13, SERPINB5
2cutaneous mucoepidermoid carcinoma30.8CRTC1, MAML2
3papillary carcinoma30.6S100A1, MUC2, CLDN3, SERPINB5
4squamous cell carcinoma30.5WIBG
5papillary thyroid carcinoma30.4SERPINB5, FOXE1, S100A1
6adenocarcinoma30.4AREG, IVL, MUC2, CLDN3, CLDN7, KRT13
7adenosquamous carcinoma30.2CEACAM7, MUC2, IVL
8gastric adenocarcinoma30.0MUC2, CLDN3, CLDN7, SERPINB5, CEACAM7
9lung cancer30.0WIBG, S100A1, AREG, MUC2, KRT13, SERPINB5
10cystadenoma30.0AREG
11hepatocellular carcinoma30.0SERPINB5, KRT13, MUC2, AREG, CEACAM7, ALDH3A1
12papilloma30.0KRT13, IVL, AREG
13hidradenoma30.0MAML2, CRTC1
14breast cancer30.0AREG, IVL, MUC2, C21orf33, CLDN3, CLDN7
15mucoepidermoid thyroid carcinoma10.8
16thyroiditis10.8
17breast mucoepidermoid carcinoma10.6
18eosinophilia10.6
19pleomorphic adenoma10.5
20pleomorphic adenoma carcinoma10.5
21pleomorphic carcinoma10.5
22adenoid cystic carcinoma10.5
23adenoiditis10.5
24thymus mucoepidermoid carcinoma10.5
25laryngeal mucoepidermoid carcinoma10.4
26lacrimal gland mucoepidermoid carcinoma10.4
27bile duct mucoepidermoid carcinoma10.4
28bone carcinoma10.4
29nasopharyngitis10.4
30mucoepidermoid esophageal carcinoma10.3
31sclerosing mucoepidermoid carcinoma with eosinophilia10.3
32acute leukemia10.3
33cervicitis10.3
34leukemia10.3
35lymphoblastic leukemia10.3
36paranasal sinus cancer10.3
37spindle cell carcinoma10.2
38ceruminous carcinoma10.2
39asthma10.2
40bile duct carcinoma10.2
41childhood leukemia10.2
42esophagitis10.2
43esophagus squamous cell carcinoma10.2
44follicular thyroid carcinoma10.2
45laryngeal carcinoma10.2
46laryngitis10.2
47middle ear carcinoma10.2
48burn scar10.0
49burns10.0
50parathyroid carcinoma10.0

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to mucoepidermoid carcinoma

Clinical Features for Mucoepidermoid Carcinoma

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Drugs & Therapeutics for Mucoepidermoid Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mucoepidermoid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Mucoepidermoid Carcinoma

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Search CenterWatch for Mucoepidermoid Carcinoma

Genetic Tests for Mucoepidermoid Carcinoma

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Anatomical Context for Mucoepidermoid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

32
Salivary gland, Thyroid, Lung, Breast, Trachea, Tongue, Skin, Thymus, Liver, Bone, Endothelial, Lymph node, Testes, Skeletal muscle, Colon, Pancreas, Bone marrow, Cervix, Tonsil, Myeloid

Animal Models for Mucoepidermoid Carcinoma or affiliated genes

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Publications for Mucoepidermoid Carcinoma

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50PubMed
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Articles related to Mucoepidermoid Carcinoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Pigmented mucoepidermoid carcinoma with spindle cell differentiation. (24275356)
2013
2
Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. (23397152)
2013
3
P63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. (23054955)
2013
4
Long term control of a maxillary sinus mucoepidermoid carcinoma with low dose radiation therapy: a case report. (24165756)
2013
5
MRI findings of mucoepidermoid carcinoma of the parotid gland: correlation with pathological features. (21896663)
2012
6
Congenital pulmonary airway malformation with mucoepidermoid carcinoma: a case report and review of literature. (23455800)
2012
7
An improved approach to diagnosing and treating conjunctival mucoepidermoid carcinoma. (22541742)
2012
8
Osteosarcoma of the mastoid process following radiation therapy of mucoepidermoid carcinoma of the parotid gland--a case report. (23397792)
2012
9
Low grade mucoepidermoid carcinoma in a setting of Warthin's tumor. (23032843)
2012
10
A case of mucoepidermoid carcinoma associated with maxillary cyst. (23124301)
2012
11
Bcl-2 protein expression in mucoepidermoid carcinoma of salivary glands: a single institution experience. (22828373)
2012
12
EGFR mutations and mucoepidermoid carcinoma: putative significance in differing populations. (22871376)
2012
13
Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. (22101257)
2012
14
Mucoepidermoid carcinoma of the lung: common findings and unusual appearances on CT. (22226436)
2012
15
Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. (21777943)
2011
16
Association of clinicopathologic parameters with the expression of inducible nitric oxide synthase and vascular endothelial growth factor in mucoepidermoid carcinoma. (21624013)
2011
17
Tracheal mucoepidermoid carcinoma. (20421766)
2010
18
High-grade oncocytic mucoepidermoid carcinoma of the minor salivary gland origin: a case report with immunohistochemical study. (20451836)
2010
19
Central mucoepidermoid carcinoma, a case report with molecular analysis of the TORC1/MAML2 gene fusion. (20625861)
2010
20
CRTC1 rearrangements in the absence of t(11;19) in primary cutaneous mucoepidermoid carcinoma. (19438452)
2009
21
Mucoepidermoid carcinoma of the thyroid and the parotid glands. (19545106)
2009
22
t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. (18486532)
2009
23
High levels of expression of cytokeratin 5 are strongly correlated with poor survival in higher grades of mucoepidermoid carcinoma. (18587014)
2008
24
Management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. (18030166)
2008
25
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. (18417848)
2008
26
A new type of MAML2 fusion in mucoepidermoid carcinoma. (18050304)
2008
27
MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. (16818685)
2006
28
Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. (16515628)
2006
29
Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. (16564385)
2006
30
Low-grade mucoepidermoid carcinoma of the subglottis treated with organ-preservation surgery. (16771028)
2006
31
Mucoepidermoid carcinoma arising from pleomorphic adenoma of the soft palate. (17119430)
2006
32
Laryngeal mucoepidermoid carcinoma: report of two cases. (16388924)
2006
33
Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation. (15725811)
2005
34
Beta-catenin and cyclin D1 in mucoepidermoid carcinoma of variable histologic grades. (16103302)
2005
35
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. (14720503)
2004
36
MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. (15054739)
2004
37
Mucoepidermoid carcinoma of the lung presenting as a cavitary lesion. (15471307)
2004
38
Mucoepidermoid carcinoma of the bronchus presenting with a negative chest X-ray and normal pulmonary function in two teenagers: two case reports and review of the literature. (14679495)
2004
39
Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst. (15006629)
2004
40
HER2/neu and Ki-67 as prognostic indicators in mucoepidermoid carcinoma of salivary glands. (14974865)
2003
41
Mucoepidermoid carcinoma of the lacrimal sac. (12616472)
2003
42
Mucoepidermoid carcinoma of the external auditory canal: case report. (12884224)
2003
43
Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. (14608545)
2003
44
Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. (11251174)
2001
45
Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. (11420454)
2001
46
Mucoepidermoid carcinoma of the trachea with airway hyperresponsiveness. (10928140)
2000
47
Mucoepidermoid carcinoma of the tracheobronchial tree: radiographic and CT findings in 12 patients. (10478226)
1999
48
Oncocytic mucoepidermoid carcinoma of the salivary glands. (10328083)
1999
49
Mucoepidermoid carcinoma arising in Warthin's tumour of the parotid gland: report of two cases with histopathological, ultrastructural and immunohistochemical studies. (9822930)
1998
50
Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. (8088769)
1994

Genetic Variations for Mucoepidermoid Carcinoma

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Expression for genes affiliated with Mucoepidermoid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Mucoepidermoid Carcinoma.

Pathways for genes affiliated with Mucoepidermoid Carcinoma

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Compounds for genes affiliated with Mucoepidermoid Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.7ALDH3A1, S100A1, AREG, IVL, MUC2, C21orf33
2paraffin4410.7S100A1, MLANA, IVL, MUC2, KRT13, SERPINB5
3hematoxylin4410.6MUC2, IVL, MLANA, S100A1
45fluorouracil4410.6WIBG, IVL, MUC2, CEACAM7
5calcium44 49 11 2413.6KRT13, CLDN3, MCAM, MUC2, IVL, CRTC1
6estrogen4410.5CEACAM7, IVL
7progesterone44 59 28 11 2414.4S100A1, AREG, MUC2, SERPINB5, CEACAM7
8mucicarmine4410.2S100A1, CEACAM7

GO Terms for genes affiliated with Mucoepidermoid Carcinoma

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16Gene Ontology
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Biological processes related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN7, CLDN3
2positive regulation of CREB transcription factor activityGO:03279310.2CRTC1, CRTC3

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:00814010.5CRTC1, CRTC3
2structural molecule activityGO:00519810.2KRT13, CLDN7, CLDN3, IVL

Products for genes affiliated with Mucoepidermoid Carcinoma

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Sources for Mucoepidermoid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet