MEC
MCID: MCP006
MIFTS: 46

Mucoepidermoid Carcinoma (MEC) malady

Rare diseases, Cancer diseases categories
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Summaries for Mucoepidermoid Carcinoma

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NIH Rare Diseases:42 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  the earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  treatment often begins with surgery to remove the entire tumor.  in some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. last updated: 6/18/2013

MalaCards based summary: Mucoepidermoid Carcinoma, also known as carcinoma mucoepidermoid, is related to cutaneous mucoepidermoid carcinoma and hidradenoma. An important gene associated with Mucoepidermoid Carcinoma is TP63 (tumor protein p63). The compounds mucicarmine and b 723 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung.

Disease Ontology:8 A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia:65 Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid... more...

Aliases & Classifications for Mucoepidermoid Carcinoma

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Mucoepidermoid Carcinoma, Aliases & Descriptions:

Name: Mucoepidermoid Carcinoma 8 42 10 62
Carcinoma Mucoepidermoid 44
 
Mec 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:4531
NCIt39 C3772
SNOMED-CT57 4079000
MeSH34 D018277

Related Diseases for Mucoepidermoid Carcinoma

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Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous mucoepidermoid carcinoma31.5CRTC1, MAML2
2hidradenoma30.6MAML2, CRTC1
3adenoma30.5TP63, CEACAM7, ANGPT2, CLDN3
4adenosquamous carcinoma30.5TP63, CEACAM7
5papillary carcinoma30.3CLDN3, TP63
6papillary thyroid carcinoma30.3TP63, ANGPT2, FOXE1
7adenocarcinoma29.9CEACAM7, TP63, CLDN3, CLDN7, ANGPT2
8gastric adenocarcinoma29.9CLDN3, CLDN7, CEACAM7
9lung cancer29.5TP63, CEACAM7, ANGPT2, WIBG
10breast cancer29.2CLDN7, ANGPT2, TP63, CEACAM7, CLDN3
11thyroiditis10.9
12sclerosing mucoepidermoid carcinoma with eosinophilia10.7
13eosinophilia10.6
14pleomorphic adenoma10.6
15adenoiditis10.6
16lung mucoepidermoid carcinoma10.5
17laryngeal mucoepidermoid carcinoma10.5
18bile duct mucoepidermoid carcinoma10.4
19lacrimal gland mucoepidermoid carcinoma10.4
20thymus mucoepidermoid carcinoma10.4
21breast mucoepidermoid carcinoma10.4
22nasopharyngitis10.4
23paranasal sinus cancer10.4
24endotheliitis10.4
25lipoadenoma10.4MAML2, CRTC1
26epithelial-myoepithelial carcinoma10.4CRTC1, MAML2
27lacrimal gland cancer10.4CRTC1, MAML2
28necrotizing sialometaplasia10.4MAML2, CRTC1
29cervical adenosquamous carcinoma10.4MAML2, CRTC1
30cavernous hemangioma10.3WIBG
31acute lymphoblastic leukemia10.3
32leukemia10.3
33mucoepidermoid esophageal carcinoma10.3
34cervicitis10.3
35lymphoblastic leukemia10.3
36warthin tumor10.3
37cleft lip10.2FOXE1, TP63
38asthma10.2
39myasthenia gravis10.2
40bronchus mucoepidermoid carcinoma10.2
41trachea mucoepidermoid carcinoma10.2
42esophagitis10.2
43oral cancer10.2
44pulmonary function10.2
45bacteremia10.2
46cleft palate10.2TP63, FOXE1
47oxyphilic adenoma10.2CLDN7, TP63
48basal cell carcinoma10.2FOXE1, TP63
49burn scar10.1
50burns10.1

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to mucoepidermoid carcinoma

Symptoms for Mucoepidermoid Carcinoma

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Drugs & Therapeutics for Mucoepidermoid Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Mucoepidermoid Carcinoma

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Genetic Tests for Mucoepidermoid Carcinoma

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Anatomical Context for Mucoepidermoid Carcinoma

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MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

32
Salivary gland, Thyroid, Lung, Breast, Trachea, Thymus, Tongue, Bone, Liver, Skin, Endothelial, Lymph node, Testes, Bone marrow, Skeletal muscle, Colon, Pancreas, Cervix, Tonsil, Myeloid

Animal Models for Mucoepidermoid Carcinoma or affiliated genes

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Publications for Mucoepidermoid Carcinoma

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Articles related to Mucoepidermoid Carcinoma:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Extracellular signala89regulated kinase inhibition is required for methanol extract of Smilax china L.a89induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells. (24270523)
2014
2
Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma. (25097648)
2014
3
Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells. (24256941)
2013
4
Nasopharyngeal mucoepidermoid carcinoma in children. (23294931)
2013
5
Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. (24035723)
2013
6
High expression of microRNAa89127 is involved in cell cycle arrest in MCa893 mucoepidermoid carcinoma cells. (23232714)
2013
7
Thoracoscopic carinal resection and reconstruction in a patient with mucoepidermoid carcinoma. (23312103)
2013
8
Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. (23464971)
2013
9
CRTC3-MAML2 fusion transcript in a bronchial mucoepidermoid carcinoma. (24150195)
2013
10
HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status. (23855785)
2013
11
Cerebellopontine angle metastasis of a parotid mucoepidermoid carcinoma arising from perineural invasion along the facial nerve. (22098392)
2012
12
Mucoepidermoid carcinoma of the pancreas: a case report and a review of literature. (23826019)
2012
13
Central mucoepidermoid carcinoma in a previously enucleated radiolucent lesion in the mandible. A case report. (22715640)
2012
14
Central mucoepidermoid carcinoma: a clinicopathologic and immunohistochemical study of 39 Chinese patients. (21989339)
2012
15
Mucoepidermoid carcinoma as a masquerade syndrome of scleral melting and granulomatous kerato-uveitis. (21484645)
2011
16
Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma. (21668476)
2011
17
Central mucoepidermoid carcinoma of maxilla with radiographic appearance of mixed radiopaque-radiolucent lesion: a case report. (21960406)
2011
18
Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. (21777943)
2011
19
Mucoepidermoid carcinoma of the sublingual gland associated with SjAPgren's syndrome. (21921353)
2011
20
Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. (20113375)
2010
21
Correlation between mucoepidermoid carcinoma grade and AgNOR count. (20587953)
2010
22
Epidermotropic metastatic mucoepidermoid carcinoma. (20489572)
2010
23
Mucoepidermoid carcinoma: a retrospective study. (20588219)
2010
24
Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression. (18239938)
2008
25
Mucoepidermoid carcinoma of the bronchus: a review. (17824797)
2007
26
Oncocytic mucoepidermoid carcinoma of a submandibular gland: a case report and review of the literature. (17331704)
2007
27
MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. (16818685)
2006
28
Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. (16444749)
2006
29
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the breast: a case report. (16780034)
2006
30
Ghrelin immunohistochemistry of gastric adenocarcinoma and mucoepidermoid carcinoma of salivary gland. (16298902)
2005
31
Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation. (15725811)
2005
32
Mucoepidermoid carcinoma of the thymus: a case report. (15308855)
2004
33
Primary intraosseous (central) salivary gland neoplasms in jaw bones: report of a mucoepidermoid carcinoma of the mandible diagnosed by fine-needle aspiration cytology. (15452902)
2004
34
Mucoepidermoid carcinoma of the breast. (14634807)
2004
35
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. (14720503)
2004
36
Mucoepidermoid carcinoma arising within nevus sebaceus of Jadassohn. (14744092)
2003
37
Mucoepidermoid carcinoma expleomorphic adenoma of the submandibular gland. (12884219)
2003
38
Synchronous bilateral mucoepidermoid carcinoma of the parotid gland. (12803799)
2003
39
Clear cell variant of mucoepidermoid carcinoma. Report of a case and a review of clear cell lesions of the oral cavity. (12800754)
2003
40
Parotid gland mucoepidermoid carcinoma in a 4-year-old child. (11879932)
2002
41
Oral pathology quiz #35. Case number 1. Mucoepidermoid carcinoma. (15658200)
2002
42
Detection of proteins and mRNA of p16, p53 and nm23 in mucoepidermoid carcinoma of salivary glands and their prognostic significance]. (11758216)
2001
43
Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland. (11598171)
2001
44
Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. (11568571)
2001
45
Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. (10912941)
2000
46
Mucoepidermoid carcinoma of the tracheobronchial tree: radiographic and CT findings in 12 patients. (10478226)
1999
47
Parotid mucoepidermoid carcinoma metastatic to pleural fluid. (10349400)
1999
48
Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. (9723598)
1998
49
Papillary variant of low-grade mucoepidermoid carcinoma--an unusual bronchial neoplasm. A light microscopic, ultrastructural, and immunohistochemical study. (8135181)
1994
50
Primary cutaneous mucoepidermoid carcinoma: report of a case. (2022766)
1991

Variations for Mucoepidermoid Carcinoma

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Expression for genes affiliated with Mucoepidermoid Carcinoma

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Expression patterns in normal tissues for genes affiliated with Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Mucoepidermoid Carcinoma.

Pathways for genes affiliated with Mucoepidermoid Carcinoma

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Compounds for genes affiliated with Mucoepidermoid Carcinoma

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Sources:
44Novoseek, 24HMDB
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Compounds related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine449.6CEACAM7, TP63
2b 723449.4CEACAM7, TP63
3thymidine44 2410.3CEACAM7, ANGPT2, TP63

GO Terms for genes affiliated with Mucoepidermoid Carcinoma

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Biological processes related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homotetramerizationGO:0512899.8CRTC1, TP63
2hair follicle morphogenesisGO:0310699.6FOXE1, TP63
3calcium-independent cell-cell adhesionGO:0163389.2CLDN7, CLDN3

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0CLDN7, CLDN3, TP63
2protein bindingGO:0055156.9CRTC1, WIBG, FBXW9, TP63, CLDN7, ANGPT2

Products for genes affiliated with Mucoepidermoid Carcinoma

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Sources for Mucoepidermoid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet