MEC
MCID: MCP006
MIFTS: 48

Mucoepidermoid Carcinoma (MEC) malady

Cancer diseases category

Summaries for Mucoepidermoid Carcinoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  the earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  treatment often begins with surgery to remove the entire tumor.  in some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. last updated: 6/18/2013

MalaCards: Mucoepidermoid Carcinoma, also known as carcinoma mucoepidermoid, is related to adenoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Mucoepidermoid Carcinoma is FOXE1 (forkhead box E1 (thyroid transcription factor 2)). The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung.

Disease Ontology:8 A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia:63 Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid... more...

Aliases & Classifications for Mucoepidermoid Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mucoepidermoid carcinoma 8 42 10 60
carcinoma mucoepidermoid 44
mec 8


External Ids:

Disease Ontology8 DOID:4531
MeSH34 D018277
SNOMED-CT56 4079000
NCIt39 C3772

Related Diseases for Mucoepidermoid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8S100A1, AREG, MUC2, CLDN3, KRT13, SERPINB5
2cutaneous mucoepidermoid carcinoma30.8CRTC1, MAML2
3papillary carcinoma30.6S100A1, MUC2, CLDN3, SERPINB5
4squamous cell carcinoma30.5WIBG
5papillary thyroid carcinoma30.4SERPINB5, FOXE1, S100A1
6adenocarcinoma30.4AREG, IVL, MUC2, CLDN3, CLDN7, KRT13
7adenosquamous carcinoma30.2CEACAM7, MUC2, IVL
8gastric adenocarcinoma30.0MUC2, CLDN3, CLDN7, SERPINB5, CEACAM7
9lung cancer30.0WIBG, S100A1, AREG, MUC2, KRT13, SERPINB5
10cystadenoma30.0AREG
11hepatocellular carcinoma30.0SERPINB5, KRT13, MUC2, AREG, CEACAM7, ALDH3A1
12papilloma30.0KRT13, IVL, AREG
13hidradenoma30.0MAML2, CRTC1
14breast cancer30.0AREG, IVL, MUC2, C21orf33, CLDN3, CLDN7
15mucoepidermoid thyroid carcinoma10.8
16thyroiditis10.8
17breast mucoepidermoid carcinoma10.6
18eosinophilia10.6
19pleomorphic adenoma10.5
20pleomorphic adenoma carcinoma10.5
21pleomorphic carcinoma10.5
22adenoid cystic carcinoma10.5
23adenoiditis10.5
24thymus mucoepidermoid carcinoma10.5
25laryngeal mucoepidermoid carcinoma10.4
26lacrimal gland mucoepidermoid carcinoma10.4
27bile duct mucoepidermoid carcinoma10.4
28bone carcinoma10.4
29nasopharyngitis10.4
30mucoepidermoid esophageal carcinoma10.3
31sclerosing mucoepidermoid carcinoma with eosinophilia10.3
32acute leukemia10.3
33cervicitis10.3
34leukemia10.3
35lymphoblastic leukemia10.3
36paranasal sinus cancer10.3
37spindle cell carcinoma10.2
38ceruminous carcinoma10.2
39asthma10.2
40bile duct carcinoma10.2
41childhood leukemia10.2
42esophagitis10.2
43esophagus squamous cell carcinoma10.2
44follicular thyroid carcinoma10.2
45laryngeal carcinoma10.2
46laryngitis10.2
47middle ear carcinoma10.2
48burn scar10.0
49burns10.0
50parathyroid carcinoma10.0

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to mucoepidermoid carcinoma

Clinical Features for Mucoepidermoid Carcinoma

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Drugs & Therapeutics for Mucoepidermoid Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mucoepidermoid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Mucoepidermoid Carcinoma

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Search CenterWatch for Mucoepidermoid Carcinoma

Genetic Tests for Mucoepidermoid Carcinoma

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Anatomical Context for Mucoepidermoid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

32
Salivary gland, Thyroid, Lung, Breast, Trachea, Tongue, Skin, Thymus, Liver, Bone, Endothelial, Lymph node, Testes, Skeletal muscle, Colon, Pancreas, Bone marrow, Cervix, Tonsil, Myeloid

Animal Models for Mucoepidermoid Carcinoma or affiliated genes

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Publications for Mucoepidermoid Carcinoma

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50PubMed
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Articles related to Mucoepidermoid Carcinoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Extracellular signala89regulated kinase inhibition is required for methanol extract of Smilax china L.a89induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells. (24270523)
2014
2
Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells. (24348795)
2014
3
Nasopharyngeal mucoepidermoid carcinoma in children. (23294931)
2013
4
Endobronchial ultrasound-guided fine-needle aspiration cytology of bronchial low-grade mucoepidermoid carcinoma: Rapid on-site evaluation of cytopathologic findings. (23008143)
2013
5
Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. (23018873)
2013
6
Simultaneous radicular cyst and mucoepidermoid carcinoma in the maxilla: a diagnostic nightmare. (23761616)
2013
7
Mucoepidermoid carcinoma of the larynx. (24036804)
2013
8
Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma. (23695589)
2013
9
A mucoepidermoid carcinoma in a young man with intellectual disability: review of oral cancer in people with intellectual disability. (23312541)
2013
10
Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases. (23114230)
2012
11
Mucoepidermoid carcinoma of the parotid presenting as periauricular cystic nodules: a series of four cases. (22524642)
2012
12
Mandibular central mucoepidermoid carcinoma with distant metastasis. (22057122)
2012
13
Cancer stem cell-like cells exist in mucoepidermoid carcinoma cell line MC3. (24139417)
2012
14
Mucoepidermoid carcinoma of the parotid gland: factors affecting outcome. (20629088)
2011
15
Giant submandibular gland tumor: mucoepidermoid carcinoma within the pleomorphic adenoma (mixed tumor). (22166363)
2011
16
Primacy of surgery in the management of mucoepidermoid carcinoma in children. (21284057)
2011
17
Diagnosis and management of mucoepidermoid carcinoma of the lacrimal duct. (21281078)
2011
18
New developments in the molecular pathogenesis of head and neck tumors: a review of tumor-specific fusion oncogenes in mucoepidermoid carcinoma, adenoid cystic carcinoma, and NUT midline carcinoma. (21238915)
2011
19
Correlation between mucoepidermoid carcinoma grade and AgNOR count. (20587953)
2010
20
Mucoepidermoid carcinoma: a retrospective study. (20588219)
2010
21
Mucoepidermoid carcinoma of the lacrimal sac masquerading as dacryocystitis. (20485052)
2010
22
Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. (19092631)
2009
23
Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. (19269006)
2009
24
Mucoepidermoid carcinoma of the thyroid gland showing marked ciliation suggestive of its pathogenesis. (18844942)
2008
25
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. (19109096)
2008
26
Mucoepidermoid carcinoma on the upper lip vermilion: a clinical report. (17414300)
2007
27
Mucoepidermoid carcinoma of the external auditory canal (EAC). (17364365)
2007
28
Mucoepidermoid carcinoma on the scalp of a child. (17845193)
2007
29
Salivary mucoepidermoid carcinoma: revisited. (17075295)
2006
30
Ghrelin immunohistochemistry of gastric adenocarcinoma and mucoepidermoid carcinoma of salivary gland. (16298902)
2005
31
SIR 2005 Annual Meeting Film Panel Case: mucoepidermoid carcinoma. (15872318)
2005
32
Conjunctival mucoepidermoid carcinoma: clear cell variant. (16157811)
2005
33
Intraosseous mucoepidermoid carcinoma of the maxilla in a teenager: a case report and review of literature. (16301142)
2005
34
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. (15011206)
2004
35
Central mucoepidermoid carcinoma of the mandible in a child. (15302154)
2004
36
Clear cell variant of mucoepidermoid carcinoma. Report of a case and a review of clear cell lesions of the oral cavity. (12800754)
2003
37
Synchronous mucoepidermoid carcinoma of tongue and pleomorphic adenoma of submandibular gland. (12627105)
2003
38
Central mucoepidermoid carcinoma of the mandible: tumorigenesis within a keratocyst. (12049571)
2002
39
Unusual presentation of mucoepidermoid carcinoma with recurrent pulmonary embolism. (12204754)
2002
40
Mucoepidermoid carcinoma of the oral cavity. (11405595)
2001
41
Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study. (11480798)
2001
42
Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: report of a case. (10930230)
2000
43
Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract. (10810423)
2000
44
Mucoepidermoid carcinoma of the eyelid skin. (10511220)
1999
45
Cytomorphologic features of mucoepidermoid carcinoma of the thyroid. (9894464)
1999
46
Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. (10211217)
1998
47
Mucoepidermoid carcinoma of the thyroid: a case report. (10879264)
1998
48
Tracheobronchial mucoepidermoid carcinoma in childhood and adolescence: case report and review of the literature. (9865445)
1998
49
Histochemistry of mucin secreting components in mucoepidermoid and adenosquamous carcinoma of the oesophagus. (7504701)
1993
50
Mucoepidermoid (adenosquamous) carcinoma arising in Barrett's esophagus. (3549205)
1987

Genetic Variations for Mucoepidermoid Carcinoma

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Expression for genes affiliated with Mucoepidermoid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucoepidermoid Carcinoma

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Pathways for genes affiliated with Mucoepidermoid Carcinoma

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Compounds for genes affiliated with Mucoepidermoid Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.7ALDH3A1, S100A1, AREG, IVL, MUC2, C21orf33
2paraffin4410.7S100A1, MLANA, IVL, MUC2, KRT13, SERPINB5
3hematoxylin4410.6MUC2, IVL, MLANA, S100A1
45fluorouracil4410.6WIBG, IVL, MUC2, CEACAM7
5calcium44 49 11 2413.6KRT13, CLDN3, MCAM, MUC2, IVL, CRTC1
6estrogen4410.5CEACAM7, IVL
7progesterone44 59 28 11 2414.4S100A1, AREG, MUC2, SERPINB5, CEACAM7
8mucicarmine4410.2S100A1, CEACAM7

GO Terms for genes affiliated with Mucoepidermoid Carcinoma

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16Gene Ontology
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Biological processes related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN7, CLDN3
2positive regulation of CREB transcription factor activityGO:03279310.2CRTC1, CRTC3

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:00814010.5CRTC1, CRTC3
2structural molecule activityGO:00519810.2KRT13, CLDN7, CLDN3, IVL

Products for genes affiliated with Mucoepidermoid Carcinoma

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Sources for Mucoepidermoid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
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50PubMed
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57SNOMED-CT via Orphanet
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