MEC
MCID: MCP006
MIFTS: 46

Mucoepidermoid Carcinoma (MEC) malady

Cancer category

Summaries for Mucoepidermoid Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  the earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  treatment often begins with surgery to remove the entire tumor.  in some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. last updated: 6/18/2013

MalaCards: Mucoepidermoid Carcinoma, also known as carcinoma mucoepidermoid, is related to adenoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Mucoepidermoid Carcinoma is FOXE1 (forkhead box E1 (thyroid transcription factor 2)). The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue.

Disease Ontology:8 A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia:64 Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid... more...

Aliases & Classifications for Mucoepidermoid Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

mucoepidermoid carcinoma 8 43 10 61
carcinoma mucoepidermoid 45
mec 8


External Ids:

Disease Ontology8 DOID:4531
MeSH35 D018277
SNOMED-CT57 4079000
NCIt40 C3772

Related Diseases for Mucoepidermoid Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.9S100A1, AREG, MUC2, CLDN3, KRT13, SERPINB5
2cutaneous mucoepidermoid carcinoma30.9CRTC1, MAML2
3papillary carcinoma30.6S100A1, MUC2, CLDN3, SERPINB5
4squamous cell carcinoma30.5WIBG
5adenocarcinoma30.4AREG, IVL, MUC2, CLDN3, CLDN7, KRT13
6adenosquamous carcinoma30.3CEACAM7, MUC2, IVL
7oral cancer30.3KRT13, IVL
8cystadenoma30.0AREG
9mucoepidermoid salivary gland carcinoma11.0
10mucoepidermoid thyroid carcinoma10.8
11breast mucoepidermoid carcinoma10.6
12pleomorphic adenoma10.6
13pleomorphic adenoma carcinoma10.6
14pleomorphic carcinoma10.6
15trachea carcinoma10.6
16warthin tumor10.6
17adenoid cystic carcinoma10.5
18thymus mucoepidermoid carcinoma10.5
19laryngeal mucoepidermoid carcinoma10.4
20lacrimal gland mucoepidermoid carcinoma10.4
21bile duct mucoepidermoid carcinoma10.4
22bone carcinoma10.4
23mucoepidermoid esophageal carcinoma10.3
24sclerosing mucoepidermoid carcinoma with eosinophilia10.3
25acute leukemia10.3
26eye carcinoma10.2
27spindle cell carcinoma10.2
28eyelid carcinoma10.2
29ceruminous carcinoma10.2
30asthma10.2
31bile duct carcinoma10.2
32acute lymphoblastic leukemia, childhood10.2
33pulmonary function10.2
34bacteremia10.2
35burn scar10.0
36parathyroid carcinoma10.0
37maxillary sinus adenoid cystic carcinoma10.0
38leukemoid reaction10.0
39cystic basal cell carcinoma10.0
40hyperlucent lung10.0
41renal clear cell carcinoma10.0
42common wart10.0
43familial adenomatous polyposis10.0
44sweat gland carcinoma10.0
45parotid gland cancer10.0
46basaloid squamous cell carcinoma10.0
47adenoid squamous cell carcinoma10.0
48cicatricial pemphigoid10.0
49anal canal carcinoma10.0
50adenoid basal cell carcinoma10.0

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to mucoepidermoid carcinoma

Clinical Features for Mucoepidermoid Carcinoma

Drugs & Therapeutics for Mucoepidermoid Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Mucoepidermoid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Mucoepidermoid Carcinoma

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Search CenterWatch for Mucoepidermoid Carcinoma

Genetic Tests for Mucoepidermoid Carcinoma

Anatomical Context for Mucoepidermoid Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

33
Skin, Liver, Tongue, Lymph node, Lung, Bone marrow, Thymus, Skeletal muscle, Colon, Pancreas, Thyroid, Salivary gland, Breast, Cervix, Tonsil, Myeloid, T cells, Endothelial, Temporal lobe, Trachea

Animal Models for Mucoepidermoid Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Mucoepidermoid Carcinoma

Sources:
51PubMed
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Articles related to Mucoepidermoid Carcinoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Large mucoepidermoid carcinoma of the maxilla in a pediatric patient. (23595246)
2013
2
Primary mucoepidermoid carcinoma of the thyroid gland: a report of three cases and review of the literature. (24096806)
2013
3
Intraosseous mucoepidermoid carcinoma: a review of the diagnostic imaging features of four jaw cases. (23524908)
2013
4
Primary mucoepidermoid carcinoma of the breast: a case report with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas. (24166608)
2013
5
Cerebellopontine angle metastasis of a parotid mucoepidermoid carcinoma arising from perineural invasion along the facial nerve. (22098392)
2012
6
CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. (22323114)
2012
7
IgG4(+) plasma cells in sclerosing variant of mucoepidermoid carcinoma. (22743285)
2012
8
Primary cutaneous mucoepidermoid carcinoma infiltrating the parotid gland. (23090800)
2012
9
Expression of the vascular endothelial growth factor and angiopoietins in mucoepidermoid carcinoma of salivary gland. (21948244)
2012
10
Clinical features and differential diagnoses in laryngeal mucoepidermoid carcinoma. (22262946)
2012
11
Mucoepidermoid carcinoma of the sublingual gland associated with SjAPgren's syndrome. (21921353)
2011
12
Mucoepidermoid carcinoma presenting as a retromolar mucocele. (23483321)
2011
13
A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant. (21437180)
2011
14
Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. (20204673)
2011
15
A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia. (21603243)
2011
16
Expression pattern of claudins 1 and 3-an auxiliary tool in predicting behavior of mucoepidermoid carcinoma of salivary gland origin. (21184237)
2011
17
Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma. (21496182)
2011
18
Mucoepidermoid carcinoma arising from the middle ear: a rare histopathologic condition. (20593545)
2010
19
CRTC1/MAML2 fusion transcript in central mucoepidermoid carcinoma of mandible--diagnostic and histogenetic implications. (21074686)
2010
20
Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. (20303042)
2010
21
Bronchial mucoepidermoid carcinoma: an unusual cause of complex cystic lung mass in a young man. (23168665)
2010
22
Bronchial mucoepidermoid carcinoma. (23168467)
2009
23
Childhood mucoepidermoid carcinoma-an interesting case. (21686868)
2009
24
Primary intraosseous mucoepidermoid carcinoma of the maxilla: a case report and review of literature. (19225087)
2009
25
Mucoepidermoid carcinoma with cutaneous infiltration similar to a subcutaneous cystic tumour. (19486053)
2009
26
High-grade mucoepidermoid carcinoma of the accessory parotid gland with distant metastases identified by 18F-FDG PET-CT. (16977607)
2008
27
Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report. (17707547)
2008
28
Mucoepidermoid carcinoma of palatinal glands with exuberant foreign-body giant cell reaction. (18538486)
2008
29
Synchronous orofacial granulomatosis and mucoepidermoid carcinoma: paraneoplastic syndrome or coincidence? (18554941)
2008
30
Case of the month. Mucoepidermoid carcinoma. (19186385)
2008
31
Paediatric intraoral mucoepidermoid carcinoma mimicking a bone lesion. (17263868)
2007
32
Mucoepidermoid carcinoma as a secondary malignancy in pediatric sarcoma. (17618873)
2007
33
Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. (16950250)
2006
34
MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. (15958852)
2005
35
Mucoepidermoid carcinoma. (16408550)
2005
36
Primary intraosseous (central) salivary gland neoplasms in jaw bones: report of a mucoepidermoid carcinoma of the mandible diagnosed by fine-needle aspiration cytology. (15452902)
2004
37
Bronchoscopic Nd-YAG laser surgery for tracheobronchial mucoepidermoid carcinoma--a report of two cases. (15587779)
2004
38
Mucoepidermoid carcinoma of the parotid gland: the Mayo clinic experience. (15262762)
2004
39
Synchronous bilateral mucoepidermoid carcinoma of the parotid gland. (12803799)
2003
40
Mucoepidermoid carcinoma of the bronchus: is conservative surgery always justified? (14716131)
2003
41
Oncocytic mucoepidermoid carcinoma of parotid gland origin. (14676764)
2003
42
Central mucoepidermoid carcinoma of the jaw in a teenager: a case report. (11815924)
2002
43
Mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland. (12445138)
2002
44
Detection of proteins and mRNA of p16, p53 and nm23 in mucoepidermoid carcinoma of salivary glands and their prognostic significance]. (11758216)
2001
45
Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland. (11598171)
2001
46
Apoptosis and apoptotic-related factors in mucoepidermoid carcinoma of the oral minor salivary glands. (10972857)
2000
47
Expression of proliferating cell nuclear antigen and tumor suppressor gene P53 in mucoepidermoid carcinoma of salivary glands]. (9592256)
1996
48
Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor. (7557943)
1995
49
Papillary variant of low-grade mucoepidermoid carcinoma--an unusual bronchial neoplasm. A light microscopic, ultrastructural, and immunohistochemical study. (8135181)
1994
50
Mucoepidermoid carcinoma metastatic to the skin. An histologic mimic of a primary sweat gland carcinoma. (1607459)
1992

Genetic Variations for Mucoepidermoid Carcinoma

Expression for genes affiliated with Mucoepidermoid Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Mucoepidermoid Carcinoma.

Pathways for genes affiliated with Mucoepidermoid Carcinoma

Compounds for genes affiliated with Mucoepidermoid Carcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid45 2411.7ALDH3A1, S100A1, AREG, IVL, MUC2, C21orf33
2paraffin4510.7SERPINB5, KRT13, MUC2, IVL, MLANA, S100A1
3hematoxylin4510.6S100A1, MLANA, IVL, MUC2
45fluorouracil4510.6MUC2, IVL, WIBG, CEACAM7
5calcium45 50 11 2413.6S100A1, AREG, CRTC1, MUC2, MCAM, CLDN3
6estrogen4510.5IVL, CEACAM7
7progesterone45 60 29 11 2414.4S100A1, AREG, MUC2, SERPINB5, CEACAM7
8mucicarmine4510.2CEACAM7, S100A1

GO Terms for genes affiliated with Mucoepidermoid Carcinoma

Sources:
16Gene Ontology
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Biological processes related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN7, CLDN3
2positive regulation of CREB transcription factor activityGO:03279310.2CRTC1, CRTC3

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:00814010.5CRTC1, CRTC3
2structural molecule activityGO:00519810.2KRT13, CLDN7, CLDN3, IVL

Products for genes affiliated with Mucoepidermoid Carcinoma

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Sources for Mucoepidermoid Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet