MEC
MCID: MCP006
MIFTS: 48

Mucoepidermoid Carcinoma (MEC) malady

Cancer diseases category

Summaries for Mucoepidermoid Carcinoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  the earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  treatment often begins with surgery to remove the entire tumor.  in some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. last updated: 6/18/2013

MalaCards: Mucoepidermoid Carcinoma, also known as carcinoma mucoepidermoid, is related to adenoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Mucoepidermoid Carcinoma is FOXE1 (forkhead box E1 (thyroid transcription factor 2)). The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung.

Disease Ontology:8 A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia:63 Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid... more...

Aliases & Classifications for Mucoepidermoid Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

mucoepidermoid carcinoma 8 42 10 60
carcinoma mucoepidermoid 44
mec 8


External Ids:

Disease Ontology8 DOID:4531
MeSH34 D018277
SNOMED-CT56 4079000
NCIt39 C3772

Related Diseases for Mucoepidermoid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8S100A1, AREG, MUC2, CLDN3, KRT13, SERPINB5
2cutaneous mucoepidermoid carcinoma30.8CRTC1, MAML2
3papillary carcinoma30.6S100A1, MUC2, CLDN3, SERPINB5
4squamous cell carcinoma30.5WIBG
5papillary thyroid carcinoma30.4SERPINB5, FOXE1, S100A1
6adenocarcinoma30.4AREG, IVL, MUC2, CLDN3, CLDN7, KRT13
7adenosquamous carcinoma30.2CEACAM7, MUC2, IVL
8gastric adenocarcinoma30.0MUC2, CLDN3, CLDN7, SERPINB5, CEACAM7
9lung cancer30.0WIBG, S100A1, AREG, MUC2, KRT13, SERPINB5
10cystadenoma30.0AREG
11hepatocellular carcinoma30.0SERPINB5, KRT13, MUC2, AREG, CEACAM7, ALDH3A1
12papilloma30.0KRT13, IVL, AREG
13hidradenoma30.0MAML2, CRTC1
14breast cancer30.0AREG, IVL, MUC2, C21orf33, CLDN3, CLDN7
15mucoepidermoid thyroid carcinoma10.8
16thyroiditis10.8
17breast mucoepidermoid carcinoma10.6
18eosinophilia10.6
19pleomorphic adenoma10.5
20pleomorphic adenoma carcinoma10.5
21pleomorphic carcinoma10.5
22adenoid cystic carcinoma10.5
23adenoiditis10.5
24thymus mucoepidermoid carcinoma10.5
25laryngeal mucoepidermoid carcinoma10.4
26lacrimal gland mucoepidermoid carcinoma10.4
27bile duct mucoepidermoid carcinoma10.4
28bone carcinoma10.4
29nasopharyngitis10.4
30mucoepidermoid esophageal carcinoma10.3
31sclerosing mucoepidermoid carcinoma with eosinophilia10.3
32acute leukemia10.3
33cervicitis10.3
34leukemia10.3
35lymphoblastic leukemia10.3
36paranasal sinus cancer10.3
37spindle cell carcinoma10.2
38ceruminous carcinoma10.2
39asthma10.2
40bile duct carcinoma10.2
41childhood leukemia10.2
42esophagitis10.2
43esophagus squamous cell carcinoma10.2
44follicular thyroid carcinoma10.2
45laryngeal carcinoma10.2
46laryngitis10.2
47middle ear carcinoma10.2
48burn scar10.0
49burns10.0
50parathyroid carcinoma10.0

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to mucoepidermoid carcinoma

Clinical Features for Mucoepidermoid Carcinoma

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Drugs & Therapeutics for Mucoepidermoid Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mucoepidermoid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Mucoepidermoid Carcinoma

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Search CenterWatch for Mucoepidermoid Carcinoma

Genetic Tests for Mucoepidermoid Carcinoma

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Anatomical Context for Mucoepidermoid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

32
Salivary gland, Thyroid, Lung, Breast, Trachea, Tongue, Skin, Thymus, Liver, Bone, Endothelial, Lymph node, Testes, Skeletal muscle, Colon, Pancreas, Bone marrow, Cervix, Tonsil, Myeloid

Animal Models for Mucoepidermoid Carcinoma or affiliated genes

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Publications for Mucoepidermoid Carcinoma

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50PubMed
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Articles related to Mucoepidermoid Carcinoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome. (23754320)
2013
2
Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells. (23975434)
2013
3
Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal. (23318008)
2013
4
Surgical Outcomes of Pulmonary Mucoepidermoid Carcinoma: A Review of 23 Cases. (23619592)
2013
5
Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma. (23035786)
2013
6
Bronchial sleeve resection for a mucoepidermoid carcinoma, mimicking asthma in a 27-year-old female. (23118089)
2012
7
Mucoepidermoid carcinoma in the external auditory canal: a case report. (23341793)
2012
8
Is it necessary to resect bone for low-grade mucoepidermoid carcinoma of the palate? (22444946)
2012
9
Central mucoepidermoid carcinoma of maxilla with radiographic appearance of mixed radiopaque-radiolucent lesion: a case report. (21960406)
2011
10
Mucoepidermoid carcinoma of the lung: a case report. (21985459)
2011
11
Mucoepidermoid carcinoma of the base of tongue. (22360050)
2011
12
Expression of mucin (MUC) genes in mucoepidermoid carcinoma. (21072847)
2011
13
Mucoepidermoid carcinoma of trachea in a 22 years old woman: a case report. (22097441)
2011
14
Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. (20113375)
2010
15
Mucoepidermoid carcinoma of an adolescent epiglottis. (21113755)
2010
16
Loss of SFRP1 expression is associated with aberrant beta-catenin distribution and tumor progression in mucoepidermoid carcinoma of salivary glands. (20162454)
2010
17
Pleomorphic adenoma with squamous and appendageal metaplasia mimicking mucoepidermoid carcinoma on cytology. (19495404)
2009
18
Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. (19116756)
2009
19
Expression and significance of basic fibroblast growth factor and transforming growth factor-beta 1 in mucoepidermoid carcinoma with different malignant degree]. (19950605)
2009
20
Cetuximab in the treatment of metastatic mucoepidermoid carcinoma of the salivary glands: a case report and review of literature. (18826647)
2008
21
A clinico-pathologic correlation. Low-grade mucoepidermoid carcinoma. (18705213)
2008
22
Mucoepidermoid carcinoma of the parotid gland with ovarian and peritoneal metastasis. (18412796)
2008
23
Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. (16444749)
2006
24
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the breast: a case report. (16780034)
2006
25
Mucoepidermoid carcinoma of the thymus. (16482933)
2006
26
Sclerosing mucoepidermoid carcinoma of the parotid gland. (16858577)
2006
27
P27, SKP2, and extra-cellular signal-related kinase signalling in human salivary gland mucoepidermoid carcinoma. (16757206)
2006
28
Mucoepidermoid carcinoma of the thymus treated by multimodality therapy: a case report. (16977299)
2006
29
Effects of 17 beta-estradiol on the adhesion, invasion and motility potential of salivary mucoepidermoid carcinoma Mc3 cells]. (16255924)
2005
30
Bronchotomy in the treatment of a low-grade bronchial mucoepidermoid carcinoma in a child. (15514618)
2004
31
Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study. (15200481)
2004
32
To the editor: Re: "Mucoepidermoid carcinoma of the bronchus presenting with a negative chest X-ray and normal pulmonary function in two teenagers: two case reports and review of the literature" by Robert J. Giusti and Raja M. Flores (Pediatric Pulmonology 2004;37:81-84). (15334519)
2004
33
Mucoepidermoid carcinoma of the palate composed exclusively of clear cells (clear cell variant). (15517374)
2004
34
Mucoepidermoid carcinoma arising within nevus sebaceus of Jadassohn. (14744092)
2003
35
Successful treatment of tracheal mucoepidermoid carcinoma using rigid bronchoscopy combined with conventional surgical resection. (14515978)
2003
36
Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. (11978546)
2002
37
Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: an autopsy case report. (11940220)
2002
38
Mucoepidermoid carcinoma of the salivary glands: clinicopathologic review of 108 patients treated at the National Cancer Institute of Milan. (12167584)
2002
39
Paediatric mucoepidermoid carcinoma of the palate. (12102409)
2002
40
Low expression of p27(Kip1) in advanced mucoepidermoid carcinomas of head and neck. (11400230)
2001
41
Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands. (10810331)
2000
42
Endobronchial mucoepidermoid carcinoma in childhood: case report and literature review. (10964741)
2000
43
Central mucoepidermoid carcinoma--a case report. (11876610)
2000
44
Mucoepidermoid carcinoma of the bronchus. (10914051)
2000
45
Oncocytic mucoepidermoid carcinoma of the trachea. (10388923)
1999
46
Sclerosing Mucoepidermoid carcinoma with eosinophilia of the thyroid glands: a case report with clinical manifestation of recurrent neck mass. (10402181)
1999
47
Mucoepidermoid carcinoma of the larynx: a case which responded completely to radiotherapy and a review of the literature. (9703863)
1998
48
Central mucoepidermoid carcinoma. (9659811)
1998
49
Primary cutaneous mucoepidermoid carcinoma: report of a case. (2022766)
1991
50
Cardiac tamponade as a presentation of mucoepidermoid bronchogenic carcinoma. (2808290)
1989

Genetic Variations for Mucoepidermoid Carcinoma

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Expression for genes affiliated with Mucoepidermoid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Mucoepidermoid Carcinoma.

Pathways for genes affiliated with Mucoepidermoid Carcinoma

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Compounds for genes affiliated with Mucoepidermoid Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2411.7ALDH3A1, S100A1, AREG, IVL, MUC2, C21orf33
2paraffin4410.7S100A1, MLANA, IVL, MUC2, KRT13, SERPINB5
3hematoxylin4410.6MUC2, IVL, MLANA, S100A1
45fluorouracil4410.6WIBG, IVL, MUC2, CEACAM7
5calcium44 49 11 2413.6KRT13, CLDN3, MCAM, MUC2, IVL, CRTC1
6estrogen4410.5CEACAM7, IVL
7progesterone44 59 28 11 2414.4S100A1, AREG, MUC2, SERPINB5, CEACAM7
8mucicarmine4410.2S100A1, CEACAM7

GO Terms for genes affiliated with Mucoepidermoid Carcinoma

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16Gene Ontology
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Biological processes related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN7, CLDN3
2positive regulation of CREB transcription factor activityGO:03279310.2CRTC1, CRTC3

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cAMP response element binding protein bindingGO:00814010.5CRTC1, CRTC3
2structural molecule activityGO:00519810.2KRT13, CLDN7, CLDN3, IVL

Products for genes affiliated with Mucoepidermoid Carcinoma

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Sources for Mucoepidermoid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet