MCID: MCP006
MIFTS: 51

Mucoepidermoid Carcinoma

Categories: Rare diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Mucoepidermoid Carcinoma

MalaCards integrated aliases for Mucoepidermoid Carcinoma:

Name: Mucoepidermoid Carcinoma 12 49 14 69
Carcinoma, Mucoepidermoid 41
Carcinoma Mucoepidermoid 51
Mec 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4531
MeSH 41 D018277
NCIt 46 C3772
SNOMED-CT 64 4079000
UMLS 69 C0206694

Summaries for Mucoepidermoid Carcinoma

NIH Rare Diseases : 49 Mucoepidermoid carcinoma is a type of cancer of the salivary glands.  Salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas.   Mucoepidermoid carcinoma develops when a cell randomly acquires changes (mutations) in genes that regulate how the cell divides such that it begins to grow quickly, forming a cluster of cells (a mass or lump).  The earliest signs of a mucoepidermoid carcinoma may include a lump in the face, neck, or mouth; numbness, weakness, or pain in part of the face; or difficulty swallowing.  Treatment often begins with surgery to remove the entire tumor.  In some cases, radiation therapy and/or chemotherapy may be used after surgery to ensure that no cancer cells remain in the body. Last updated: 6/18/2013

MalaCards based summary : Mucoepidermoid Carcinoma, also known as carcinoma, mucoepidermoid, is related to lacrimal gland mucoepidermoid carcinoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Mucoepidermoid Carcinoma is CRTC1 (CREB Regulated Transcription Coactivator 1), and among its related pathways/superpathways are Development EGFR signaling pathway and CLEC7A (Dectin-1) signaling. The drugs Emend and Doxepin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Disease Ontology : 12 A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Wikipedia : 72 Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults.... more...

Related Diseases for Mucoepidermoid Carcinoma

Diseases related to Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 lacrimal gland mucoepidermoid carcinoma 34.3 CRTC1 MAML2
2 cutaneous mucoepidermoid carcinoma 33.4 CEACAM5 CRTC1 KRT7 MAML2
3 breast mucoepidermoid carcinoma 33.4 CEACAM5 MUC1 MUC5AC
4 mucoepidermoid thyroid carcinoma 32.3 CALCA TG
5 bile duct mucoepidermoid carcinoma 32.1 CEACAM5 KRT7 MUC1 MUC2 MUC4 MUC5AC
6 pleomorphic adenoma 30.9 ERBB2 KRT14 MUC1 TP63
7 adenocarcinoma 30.5 EGFR ERBB2 MUC1 MUC4
8 oral cancer 30.2 EGFR KRT13 PCNA
9 hidradenoma 30.1 CRTC1 KRT7 MAML2 MUC1
10 warthin tumor 30.0 CEACAM5 CRTC1 CRTC3 KRT7 MAML2
11 adenosquamous carcinoma 30.0 EGFR KRT7 MUC1 MUC4 TP63
12 papillary carcinoma 29.8 CALCA ERBB2 KRT7 MUC1 TG
13 mucinous adenocarcinoma 29.8 EGFR KRT7 MUC1 MUC2
14 basaloid squamous cell carcinoma 29.8 EGFR KRT13 KRT14 KRT7
15 papilloma 29.4 KRT13 KRT14 KRT7 PCNA TP63
16 squamous cell carcinoma 29.1 CEACAM5 EGFR ERBB2 KRT7 MKI67 MUC1
17 cystadenoma 29.1 CHGA KRT7 MUC1 MUC2 MUC4
18 gastric adenocarcinoma 28.9 CEACAM5 CHGA ERBB2 MUC4
19 lung cancer 27.6 AREG CEACAM5 CHGA EGFR ERBB2 KRT7
20 sclerosing mucoepidermoid carcinoma with eosinophilia 12.4
21 thymus mucoepidermoid carcinoma 12.2
22 lung mucoepidermoid carcinoma 12.2
23 laryngeal mucoepidermoid carcinoma 12.2
24 bronchus mucoepidermoid carcinoma 11.9
25 trachea mucoepidermoid carcinoma 11.9
26 mucoepidermoid esophageal carcinoma 11.4
27 paranasal sinus cancer 11.2
28 schneiderian carcinoma 10.6 CRTC1 MAML2
29 breast intraductal proliferative lesion 10.6 EGFR ERBB2
30 cervical adenosquamous carcinoma 10.6 CRTC1 EGFR MAML2
31 breast cystic hypersecretory carcinoma 10.5 ERBB2 TG
32 clear cell hidradenoma 10.5 CRTC1 MAML2
33 thyroiditis 10.5
34 malignant peritoneal mesothelioma 10.5 EGFR MUC1
35 progesterone-receptor negative breast cancer 10.5 EGFR ERBB2
36 cystic basal cell carcinoma 10.5 KRT7 TP63
37 breast scirrhous carcinoma 10.5 EGFR ERBB2 MUC1
38 suppurative thyroiditis 10.5 CALCA TG
39 thyroid sarcoma 10.5 CALCA TG
40 brain ependymoma 10.4 EGFR MKI67
41 lipid-rich carcinoma 10.4 EGFR ERBB2 KRT14
42 middle ear adenoma 10.4 KRT7 MUC1
43 pancreatic intraductal papillary-mucinous neoplasm 10.4 MUC1 MUC2
44 epispadias 10.4 CALCA ERBB2 TP63
45 pre-malignant neoplasm 10.4 EGFR ERBB2 KRT14
46 sinonasal undifferentiated carcinoma 10.4 MKI67 MUC1
47 ovarian germ cell teratoma 10.4 KRT7 TG
48 in situ carcinoma 10.4 EGFR ERBB2 KRT14
49 endosalpingiosis 10.4 KRT7 MUC1
50 glandular cystitis 10.4 KRT7 MUC1

Graphical network of the top 20 diseases related to Mucoepidermoid Carcinoma:



Diseases related to Mucoepidermoid Carcinoma

Symptoms & Phenotypes for Mucoepidermoid Carcinoma

MGI Mouse Phenotypes related to Mucoepidermoid Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 AREG CHGA CRTC1 EGFR ERBB2 KRT14
2 homeostasis/metabolism MP:0005376 9.4 AREG CHGA CRTC1 CRTC3 EGFR ERBB2

Drugs & Therapeutics for Mucoepidermoid Carcinoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Emend 17 45 APREPITANT FOSAPREPITANT DIMEGLUMINE Merck March 2003

Drugs for Mucoepidermoid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxepin Approved, Investigational Phase 3 1668-19-5 667468 667477
2
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
5
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
6
Cevimeline Approved Phase 3 107233-08-9 25137844 83898
7
Megestrol acetate Approved, Investigational, Vet_approved Phase 3 595-33-5 11683
8 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
9
Docetaxel Approved May 1996, Investigational Phase 3,Phase 1,Phase 2 114977-28-5 148124 9877265
10 Liver Extracts Phase 3,Phase 2,Phase 1
11 Anti-Infective Agents Phase 2, Phase 3,Phase 1
12 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
13 Antimitotic Agents Phase 3,Phase 1,Phase 2
14 Antidepressive Agents Phase 3
15 Antidepressive Agents, Tricyclic Phase 3
16 Histamine Antagonists Phase 3
17
Histamine Phosphate Phase 3 51-74-1 65513
18 Neurotransmitter Agents Phase 3
19 Psychotropic Drugs Phase 3
20 Adjuvants, Anesthesia Phase 3
21 Analgesics Phase 3
22 Analgesics, Opioid Phase 3
23 Anesthetics Phase 3
24 Anesthetics, General Phase 3
25 Anesthetics, Intravenous Phase 3
26 Central Nervous System Depressants Phase 3
27 Narcotics Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Antifungal Agents Phase 2, Phase 3,Phase 1
30 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
31 Hormone Antagonists Phase 2, Phase 3
32 Hormones Phase 2, Phase 3,Phase 1
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
34 Steroid Synthesis Inhibitors Phase 2, Phase 3
35 Autonomic Agents Phase 3
36 Cholinergic Agents Phase 3
37 Antineoplastic Agents, Hormonal Phase 3
38 Appetite Stimulants Phase 3
39 Central Nervous System Stimulants Phase 3
40 Contraceptive Agents Phase 3
41 Contraceptives, Oral Phase 3
42
Megestrol Phase 3 3562-63-8 3080587 19090
43 Cola Nutraceutical Phase 3,Phase 2,Phase 1
44
Amifostine Approved, Investigational Phase 1, Phase 2 20537-88-6 2141
45
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
46
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
47
Indinavir Approved Phase 2 150378-17-9 5362440
48
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
49
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
50
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3

Interventional clinical trials:

(show top 50) (show all 78)

# Name Status NCT ID Phase Drugs
1 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract Completed NCT00765440 Phase 3
4 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
5 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3 fluconazole
6 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3 cevimeline hydrochloride
7 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3 megestrol acetate
8 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3 Hypericum perforatum;docetaxel
9 Amifostine Plus Chemotherapy and Radiation Therapy in Treating Patients With Advanced, Unresectable Head and Neck Cancer Unknown status NCT00003251 Phase 1, Phase 2 amifostine trihydrate;cisplatin;paclitaxel
10 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
11 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
12 Paclitaxel in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer Completed NCT00002632 Phase 2 paclitaxel
13 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
14 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer Completed NCT00101348 Phase 1, Phase 2 erlotinib hydrochloride
15 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed NCT00095563 Phase 2 lapatinib ditosylate
16 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
17 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
18 Docetaxel in Treating Patients With Solid Tumors Completed NCT00003565 Phase 2 docetaxel
19 Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer Completed NCT00448552 Phase 2 capecitabine;oxaliplatin
20 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Completed NCT00004901 Phase 1, Phase 2 ethynyluracil;fluorouracil;hydroxyurea
21 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2 capecitabine;carboplatin;epirubicin hydrochloride
22 Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors Completed NCT00019331 Phase 2 DetoxPC
23 Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer Completed NCT00004163 Phase 2 Trastuzumab
24 Cisplatin or Carboplatin Combined With Gemcitabine in Treating Patients With Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor Completed NCT00079079 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride
25 Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer Completed NCT00509665 Phase 2 doxorubicin hydrochloride;gemcitabine hydrochloride
26 Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Completed NCT00021333 Phase 2 cisplatin;paclitaxel
27 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy Recruiting NCT01806675 Phase 1, Phase 2 fludeoxyglucose F 18;2-fluoropropionyl-labeled pegylated dimeric RGD peptide
28 Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery Recruiting NCT01220583 Phase 2 cisplatin
29 Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors Active, not recruiting NCT00859937 Phase 2 dasatinib
30 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2
31 Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer Terminated NCT00126607 Phase 2
32 Title XELOX FOR SALIVARY GLAND CANCERS Terminated NCT00101075 Phase 2 Capecitabine;Oxaliplatin
33 MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer Unknown status NCT00984074 Phase 1
34 Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors Completed NCT00089362 Phase 1 alvespimycin hydrochloride
35 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
36 Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00023959 Phase 1 hydroxyurea;fluorouracil
37 Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer Completed NCT01637194 Phase 1 everolimus
38 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
39 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
40 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
41 Head & Neck Cancer Survivorship: Physical and Functional Status Completed NCT00751816 Phase 1 systemic chemotherapy
42 Pemetrexed Disodium and Docetaxel in Treating Patients With Advanced Solid Tumors Completed NCT01172028 Phase 1 Taxotere (Docetaxel);Alimta (Pemetrexed)
43 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
44 Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors Completed NCT00006036 Phase 1 cisplatin;lurtotecan liposome
45 Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function Completed NCT00002901 Phase 1 docetaxel
46 Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed NCT00045006 Phase 1 vorinostat
47 Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer Completed NCT00019110 Phase 1
48 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1 capecitabine;cisplatin
49 Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer Completed NCT00004065 Phase 1 tanespimycin
50 NGR-TNF in Treating Patients With Advanced Solid Tumors Completed NCT00098943 Phase 1

Search NIH Clinical Center for Mucoepidermoid Carcinoma

Cochrane evidence based reviews: carcinoma, mucoepidermoid

Genetic Tests for Mucoepidermoid Carcinoma

Anatomical Context for Mucoepidermoid Carcinoma

MalaCards organs/tissues related to Mucoepidermoid Carcinoma:

38
Salivary Gland, Thyroid, Lung, Brain, Liver, Skin, Breast

Publications for Mucoepidermoid Carcinoma

Articles related to Mucoepidermoid Carcinoma:

(show top 50) (show all 704)
# Title Authors Year
1
Apoptosis induced by methanol extract of PotentillaA discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. ( 29363716 )
2018
2
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment. ( 29338644 )
2018
3
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells. ( 29353885 )
2018
4
Mucoepidermoid Carcinoma of Arising from a Bronchogenic Cyst of the Diaphragm. ( 29367500 )
2018
5
Clinicopathological characteristics and molecular analysis of primary pulmonary mucoepidermoid carcinoma: Case report and literature review. ( 29388384 )
2018
6
Mucoepidermoid Carcinoma: A 23-Year Experience with Emphasis on Low-Grade Tumors with Close/Positive Margins. ( 29313462 )
2018
7
Central mucoepidermoid carcinoma: An up-to-date analysis of 147 cases and review of prognostic factors. ( 29198377 )
2018
8
Mucoepidermoid carcinoma mimicking a mucocele (ranula) in the floor of the mouth. ( 29231036 )
2018
9
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type. ( 29415898 )
2018
10
Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report. ( 29131467 )
2018
11
Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges. ( 29445552 )
2017
12
MAML2 Rearrangements in Variant Forms of Mucoepidermoid Carcinoma: Ancillary Diagnostic Testing for the Ciliated and Warthin-like Variants. ( 28877061 )
2017
13
Mucoepidermoid carcinoma-associated expression of MUC5AC, MUC5B and mucin-type carbohydrate antigen sialyl-Tn in the parotid gland. ( 28628803 )
2017
14
Contrast-enhanced endoscopic ultrasonography features of a mucoepidermoid carcinoma of the pancreas. ( 28836518 )
2017
15
A case of central mucoepidermoid carcinoma associated with dentigerous cyst. ( 29238382 )
2017
16
Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: the MD Anderson Cancer Center experience and comprehensive review of the literature. ( 28343305 )
2017
17
Intraosseous mucoepidermoid carcinoma: Outcome review. ( 28833169 )
2017
18
18F-FDG PET/CT Imaging of Tracheal Mucoepidermoid Carcinoma. ( 28872555 )
2017
19
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma. ( 28711734 )
2017
20
Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report. ( 28927048 )
2017
21
Bulbar conjunctival metastasis from mucoepidermoid carcinoma of parotid-a case report and review of literature. ( 28061862 )
2017
22
Expression of Vascular Endothelial-Cadherin in Mucoepidermoid Carcinoma: Role in Cancer Development. ( 29387612 )
2017
23
Cytological features of the Warthin-like variant of salivary mucoepidermoid carcinoma. ( 28755513 )
2017
24
A Rare Cause of Duodenal Obstruction: Metastatic Parotid Mucoepidermoid Carcinoma. ( 28351791 )
2017
25
Primary mucoepidermoid carcinoma of the lung with prominent clear cells. ( 28670072 )
2017
26
Nasal cavity tumefactive fibroinflammatory lesion mimicking recurrent mucoepidermoid carcinoma. ( 28846782 )
2017
27
Mucoepidermoid Carcinoma in the Skull of an Orange-winged Amazon Parrot (Amazona amazonica). ( 28891704 )
2017
28
Low-Grade Mucoepidermoid Carcinoma of the Lacrimal Gland in a Teenaged Patient. ( 29318070 )
2017
29
Perineural Spread of Mucoepidermoid Carcinoma of Parotid Gland Involving V, VI, and VII Cranial Nerves Demonstrated on Positron Emission Tomography/Computed Tomography. ( 28680219 )
2017
30
Prognostic factors and occult nodal disease in mucoepidermoid carcinoma of the oral cavity and oropharynx: An analysis of the National Cancer Database. ( 28797455 )
2017
31
Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With CRTC1-MAML2 Fusion Transcript: Report of a Rare Case in a 17-Year-Old Boy and a Review of the Literature. ( 28637362 )
2017
32
Mucoepidermoid Carcinoma of Salivary Gland: Limitations and Pitfalls on FNA. ( 28658793 )
2017
33
Microencapsulation of low-passage poorly-differentiated human mucoepidermoid carcinoma cells by alginate microcapsules: in vitro profiling of angiogenesis-related molecules. ( 29200966 )
2017
34
Low grade mucoepidermoid carcinoma of a minor salivary gland of the tongue in a paediatric patient. ( 29106823 )
2017
35
Penile warty mucoepidermoid carcinoma with features of stratified mucin-producing intra-epithelial lesion and invasive stratified mucin-producing carcinoma. ( 29144557 )
2017
36
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature. ( 28516348 )
2017
37
Mucoepidermoid Carcinoma in a 62-Year Female. ( 29185413 )
2017
38
Warthin Tumor-Like Mucoepidermoid Carcinoma. ( 28793830 )
2017
39
Dermoscopic features of mucoepidermoid carcinoma of the lip. ( 28593658 )
2017
40
Mucoepidermoid carcinoma of the breast: Four case reports and review of the literature. ( 29390541 )
2017
41
Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase. ( 28649694 )
2017
42
Fluorine-18-fluorodeoxyglucose positron emission tomography/ computed tomography findings in a pediatric mucoepidermoid carcinoma and differential diagnosis. ( 28697196 )
2017
43
Sclerosing Mucoepidermoid Carcinoma in the Parotid Gland With CRTC1-MAML2 Fusion: A Case Report. ( 29169286 )
2017
44
Case Report: Recurrent Mucoepidermoid Carcinoma of the Tongue in Adult Female Patient With Lung Cancer. ( 28757800 )
2017
45
Locally Advanced Stage High-Grade Mucoepidermoid Carcinoma of Salivary Gland in a 9-Year-Old Girl: The Controversy of Adjuvant Therapy. ( 27746885 )
2016
46
Primary Mucoepidermoid Carcinoma of the Lacrimal Sac -a88 a Case Report and Literature Review. ( 27534787 )
2016
47
Massive hemoptysis due to primary mucoepidermoid carcinoma of the lung in a 12-year-old. ( 27216748 )
2016
48
Twist Expression in Pleomorphic Adenoma, Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of Salivary Glands. ( 26832177 )
2016
49
Role of CRTC1/MAML2 Translocation in the Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma. ( 26796488 )
2016
50
Central mucoepidermoid carcinoma radiographically mimicking an odontogenic tumor: A case report and literature review. ( 27721620 )
2016

Variations for Mucoepidermoid Carcinoma

Cosmic variations for Mucoepidermoid Carcinoma:

9 (show all 40)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM43797 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.550G>C p.D184H 15
2 COSM46282 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.501G>C p.Q167H 15
3 COSM44853 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.661G>A p.E221K 15
4 COSM44850 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.494A>T p.Q165L 15
5 COSM46283 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.569C>A p.P190H 15
6 COSM43680 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.523C>T p.R175C 15
7 COSM44119 TP53 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.483C>T p.A161A 15
8 COSM1389051 SMAD4 salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.993G>A p.M331I 15
9 COSM5069 PTEN salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.760A>G p.K254E 15
10 COSM546 KRAS salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.175G>A p.A59T 15
11 COSM483 HRAS salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.35G>T p.G12V 15
12 COSM491 HRAS salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.39T>A p.G13G 15
13 COSM484 HRAS salivary gland,NS,carcinoma,mucoepidermoid carcinoma c.35G>A p.G12D 15
14 COSM51381 KIT salivary gland,face,carcinoma,NS c.2386A>G p.R796G 12
15 COSM1659071 WASF2 salivary gland,mouth floor,carcinoma,NS c.15G>T p.T5T 11
16 COSM1659031 TRPV5 salivary gland,mouth floor,carcinoma,NS c.554A>G p.H185R 11
17 COSM1658989 TP53BP1 salivary gland,mouth floor,carcinoma,NS c.3854C>G p.T1285S 11
18 COSM1659046 THRA salivary gland,mouth floor,carcinoma,NS c.1162C>T p.R388W 11
19 COSM1658912 SLC26A2 salivary gland,mouth floor,carcinoma,NS c.1474C>T p.R492W 11
20 COSM1659033 RNF38 salivary gland,mouth floor,carcinoma,NS c.623A>G p.H208R 11
21 COSM1659036 MELK salivary gland,mouth floor,carcinoma,NS c.817T>C p.W273R 11
22 COSM1659003 MAP2 salivary gland,mouth floor,carcinoma,NS c.31G>T p.A11S 11
23 COSM51382 KRAS salivary gland,mouth floor,carcinoma,NS c.50G>A p.S17N 11
24 COSM1658780 KDM6A salivary gland,mouth floor,carcinoma,NS c.2833-1G>A p.? 11
25 COSM1658957 HNRNPDL salivary gland,mouth floor,carcinoma,NS c.289C>T p.R97C 11
26 COSM1658892 HK1 salivary gland,mouth floor,carcinoma,NS c.370C>G p.H124D 11
27 COSM1659047 HECTD4 salivary gland,mouth floor,carcinoma,NS c.6707G>A p.S2236N 11
28 COSM1658983 GTF3C3 salivary gland,mouth floor,carcinoma,NS c.2602C>G p.Q868E 11
29 COSM1658965 DYRK4 salivary gland,mouth floor,carcinoma,NS c.1733G>A p.R578H 11
30 COSM1658899 COL22A1 salivary gland,mouth floor,carcinoma,NS c.4115G>C p.G1372A 11
31 COSM1658935 CHEK2 salivary gland,mouth floor,carcinoma,NS c.508G>A p.V170I 11
32 COSM1658880 CDAN1 salivary gland,mouth floor,carcinoma,NS c.2248G>T p.G750C 11
33 COSM51383 BRAF salivary gland,mouth floor,carcinoma,NS c.1768G>A p.V590I 11
34 COSM34223 AXL salivary gland,mouth floor,carcinoma,NS c.1522G>A p.G508S 11
35 COSM1658913 salivary gland,mouth floor,carcinoma,NS c.1657G>A p.G553R 11
36 COSM1658893 salivary gland,mouth floor,carcinoma,NS c.358C>G p.H120D 11
37 COSM1658951 salivary gland,mouth floor,carcinoma,NS c.236G>A p.R79H 11
38 COSM1658894 salivary gland,mouth floor,carcinoma,NS c.355C>G p.H119D 11
39 COSM1659048 salivary gland,mouth floor,carcinoma,NS c.7457G>A p.S2486N 11
40 COSM1659004 salivary gland,mouth floor,carcinoma,NS c.31G>T p.A11S 11

Expression for Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Mucoepidermoid Carcinoma.

Pathways for Mucoepidermoid Carcinoma

GO Terms for Mucoepidermoid Carcinoma

Cellular components related to Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AREG CALCA CHGA EGFR MUC1 MUC4
2 Golgi lumen GO:0005796 8.92 MUC1 MUC2 MUC4 MUC5AC
3 nucleus GO:0005634 10 AREG CALCA CRTC1 CRTC3 EGFR ERBB2

Biological processes related to Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homotetramerization GO:0051289 9.54 CRTC1 CRTC3 TP63
2 epithelial cell differentiation GO:0030855 9.5 KRT14 PCNA TP63
3 response to lipid GO:0033993 9.48 EGFR PCNA
4 negative regulation of ERBB signaling pathway GO:1901185 9.46 EGFR ERBB2
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.46 MUC1 MUC2 MUC4 MUC5AC
6 positive regulation of cAMP metabolic process GO:0030816 9.43 CALCA CHGA
7 positive regulation of DNA replication GO:0045740 9.43 AREG EGFR PCNA
8 cell proliferation GO:0008283 9.43 AREG EGFR ERBB2 MKI67 PCNA TP63
9 maintenance of gastrointestinal epithelium GO:0030277 9.4 MUC2 MUC4
10 O-glycan processing GO:0016266 8.92 MUC1 MUC2 MUC4 MUC5AC

Molecular functions related to Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 EGFR ERBB2
2 cAMP response element binding protein binding GO:0008140 8.62 CRTC1 CRTC3

Sources for Mucoepidermoid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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