Mucopolysaccharidosis malady

NINDS: The mucopolysaccharidoses are a group of inherited metabolic diseases in which a defective or missing enzyme causes large amounts of complex sugar molecules to accumulate in harmful amounts in the body's cells and tissues.³¹

MalaCards: Mucopolysaccharidosis, also known as mucopolysaccharidoses, is related to mucopolysaccharidosis i and mucopolysaccharidosis vii. An important gene associated with Mucopolysaccharidosis is IDUA (iduronidase, alpha-L-), and among its related pathways are CS/DS degradation and Glycosphingolipid biosynthesis - globo series. The compounds (z)-pugnac and glucuronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and brain, and related mouse phenotypes are hearing/vestibular/ear and reproductive system.

Disease Ontology: A lysosomal storage disease that involves he accumulation of glycosaminoglycans in the tissues and their excretion in the urine.⁶

Wikipedia: Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of...⁴⁴ more...

Aliases & Descriptions:

mucopolysaccharidosis 6 44 30 8 32 mucopolysaccharidoses 6 31 43 mucopolysaccharidosis nos (disorder) 6

mucopolysaccharidosis (disorder) 6 mps 30

Disease types for mucopolysaccharidosis family:

mucopolysaccharidosis vi	mucopolysaccharidosis i
mucopolysaccharidosis vii	mucopolysaccharidosis iv
mucopolysaccharidosis iii	mucopolysaccharidosis ii
mucopolysaccharidosis ih	mucopolysaccharidosis ivb
mucopolysaccharidosis type iiid	mucopolysaccharidosis type ix
mucopolysaccharidosis type iiic	mucopolysaccharidosis type iiib (sanfilippo b)
mucopolysaccharidosis type vi (maroteaux-lamy)	mucopolysaccharidosis type ivb (morquio)
mucopolysaccharidosis type iiic (sanfilippo c)

Diseases related to mucopolysaccharidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 140)

id	Related Disease	Score	Top Affiliating Genes
1	mucopolysaccharidosis i	35.5	IDUA, ARSH
2	mucopolysaccharidosis vii	35.1	IDUA, GUSB
3	mucopolysaccharidosis vi	34.8	ARSB, ARSA, ARSH
4	mucopolysaccharidosis iii	34.3	SGSH, NAGLU, ARSH, M6PR
5	mucopolysaccharidosis ii	34.3	IDS, ARSH
6	mucopolysaccharidosis iv	33.7	GALNS, CRTAP, LGSN
7	hurler syndrome	31.3	GLB1, IDUA
8	scheie syndrome	31.2	IDUA, LCAT
9	mucopolysaccharidosis type ix	30.4	SPAM1, HYAL4, HYAL3, HYAL2, HYAL1
10	craniofacial abnormalities	28.6	IDUA, ARSB, GUSB
11	corneal clouding	27.7	GALNS, GLB1, IDUA, ARSB, GUSB
12	mucosulfatidosis	27.3	SUMF1, ARSB, ARSA, ARSH
13	gangliosidosis	27.0	GALNS, HEXB, HEXA, GLB1, GLA, ARSA
14	blindness	25.7	DSPP, HEXB, GLA, HYAL1, IDUA, IGF2
15	lysosomal storage disease	25.3	GLA, GLB1, M6PR, SUMF1, HEXA, HEXB
16	fibrosis	25.0	GALNS, ADA, HEXA, ELN, GLB1, IGF2
17	periodontitis	24.6	DSPP, HEXA, ELN, SPAM1, GLA, HYAL2
18	neurodegeneration	24.3	HEXB, HEXA, SUMF1, ALAS2, IGF2, MAPT
19	retinitis	22.5	MAPT, IGF2, SUMF1, ELN, ADA, GALNS
20	mucolipidosis ii	13.6	GUSB, ARSH, M6PR
21	mucolipidoses	13.4	HYAL1, GUSB
22	sandhoff disease	13.4	ARSA, HEXA, HEXB
23	krabbe disease	13.4	HEXA, GLB1, ARSA
24	glycogen storage disease ii	13.4	GAA, M6PR, IDUA
25	fabry disease	13.3	M6PR, GLA, ARSA, GUSB
26	tay-sachs disease	13.3	HEXB, HEXA, GLA, ARSA
27	gangliosidosis gm1	13.3	GALNS, HEXA, GLB1, GLA, ARSA
28	metachromatic leukodystrophy	13.1	HEXA, SUMF1, GLA, ARSB, ARSA, ARSH
29	ichthyosis	13.0	SUMF1, ARSB, ARSA, ARSE, ARSH
30	mucolipidosis	13.0	HEXA, SUMF1, GLB1, ARSA, ARSH, GUSB
31	leukodystrophy	12.9	GALNS, HEXA, SUMF1, GLA, IDUA, ARSB
32	gaucher's disease	12.8	ADA, HEXA, GLA, IDUA, ARSA, ARSH
33	chondrodysplasia punctata	12.8	SUMF1, ARSB, ARSA, ARSE, ARSH, ARSD
34	chondrodysplasia	12.8	SUMF1, ARSB, ARSA, ARSE, ARSH, ARSD
35	costello syndrome	12.8	IGF2, GLB1, ELN
36	lymphangioleiomyomatosis	12.7	ELN, GLB1, IGF2, FGF2
37	autonomic dysfunction	12.7	HEXB, GLA, MAPT, ARSH
38	purine-pyrimidine metabolic disorder	12.6	APRT, ADA
39	wilson disease	12.6	NAGLU, ARSA, APP, ELN
40	bilirubin metabolic disorder	12.4	GAA, ADA, HEXA, GLA, IDUA, APRT
41	mayer-rokitansky-kuster-hauser syndrome	12.4	GABRA3, ADA, HSD17B13, ARSA, ARSH
42	chronic kidney failure	12.4	ADA, GLA, IGF2, APRT, LCAT, NAGLU
43	liver cirrhosis	12.3	ADA, IGF2, FGF2, ARSH, GUSB, LCAT
44	niemann–pick disease	12.3	HEXA, M6PR, MAPT, APP, LCAT
45	short stature	12.2	GALNS, DSPP, CRTAP, GLB1, HYAL1, IGF2
46	fibrosarcoma	12.1	GALNS, ELN, GLB1, IGF2, APRT, FGF2
47	peritonitis	12.1	ADA, ELN, HYAL2, HYAL1, IGF2, FGF2
48	pick's disease	12.0	LCAT, APP, MAPT, M6PR
49	hydrocephalus	11.9	SUMF1, MAPT, APP, ARSB, ARSA, ARSH
50	cystic fibrosis	11.9	GALNS, ADA, HEXA, ELN, GLB1, IGF2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to mucopolysaccharidosis:

²²

MGI Mouse Phenotypes related to mucopolysaccharidosis:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	9.6	HEXA, IDUA, FGF2, ARSB, ARSA, GUSB
2	reproductive system phenotype	MP:0005389	8.6	SPAM1, M6PR, GLB1, IDUA, APP, FGF2
3	craniofacial phenotype	MP:0005382	8.2	HYAL2, SUMF1, HEXA, HEXB, DSPP, IDUA
4	liver/biliary system phenotype	MP:0005370	7.9	GLA, GLB1, SUMF1, HEXA, HEXB, ADA
5	vision/eye phenotype	MP:0005391	7.8	IDUA, HYAL2, HEXA, HEXB, GALNS, IGF2
6	skeleton phenotype	MP:0005390	7.4	M6PR, SUMF1, CRTAP, HEXA, HEXB, ADA
7	renal/urinary system phenotype	MP:0005367	7.3	SGSH, GALNS, ADA, HEXB, HEXA, M6PR
8	hematopoietic system phenotype	MP:0005397	6.9	IGF2, IDUA, HYAL2, ALAS2, GLB1, SUMF1
9	homeostasis/metabolism phenotype	MP:0005376	6.0	GLB1, M6PR, ELN, HEXA, HEXB, ADA
10	cellular phenotype	MP:0005384	6.0	GLA, GLB1, M6PR, SUMF1, HEXB, ADA
11	behavior/neurological phenotype	MP:0005386	5.8	IDUA, GLA, GLB1, M6PR, SUMF1, HEXA

Articles related to mucopolysaccharidosis:

(show top 50)    (show all 330)

id	Title	Authors	Year	Affiliating Genes
1	Mucopolysaccharidosis type I: molecular characteristi cs of two novel alpha-L-iduronidase mutations in Tunisian patients. (21639919)	Chkioua L.... Miled A.	2011	IDUA
2	Characterization of the biosynthesis, processing and kinetic mechanism of action of the enzyme deficient in mucopolysaccharidosis II IC. (21957468)	Fan X.... Mahuran D.	2011	HGSNAT
3	Mucopolysaccharidosis VI. (20385007)	Valayannopoulos V.... Turbeville S.	2010	ARSB, ARSH
4	Mucopolysaccharidosis IVA mutations in Chinese patien ts: 16 novel mutations. (20574428)	Wang Z.... Huang S.	2010	GALNS
5	Dermatan sulfate and heparan sulfate as a biomarker f or mucopolysaccharidosis I. (20162367)	Tomatsu S.... Orii T.	2010	IDUA
6	Identification and characterization of a novel homozy gous deletion in the alpha-N-acetylglucosaminidase gene in a patient with Sanfi lippo type B syndrome (mucopolysaccharidosis IIIB). (20138557)	Champion K.J.... Maystadt I.	2010	NAGLU
7	Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome). (19224584)	Tomatsu S.... Sly W.S.	2009	GUSB
8	Enzyme replacement therapy with idursulfase in patients with mucopolysaccharidosis type II. (18339193)	Wraith J.E.	2008	IDS
9	Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis I. (19042989)	Blanchard S.... Gelb M.H.	2008	IDUA
10	Genetic analysis of mucopolysaccharidosis type VI in Taiwanese patients. (18486607)	Lin W.D.... Tsai F.J.	2008	ARSB
11	Mucopolysaccharidosis type I: identification of alpha-L-iduronidase mutations in Tunisian families (17728118)	Chkioua L.... Laradi S.	2007	IDUA
12	Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy. (17519893)	Traas A.M.... Ponder K.P.	2007	IDUA
13	Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice. (17460717)	Fu H.... Muenzer J.	2007	NAGLU
14	Identification of the molecular defects in Spanish and Argentinian mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) patients, including 9 novel mutations. (17643332)	Garrido E.... Cormand B.	2007	ARSB
15	Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C). (16960811)	Fan X.... Mahuran D.J.	2006	HGSNAT
16	Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. (16647419)	Harmatz P.... Swiedler S.J.	2006	ARSB
17	Prediction of neuropathology in mucopolysaccharidosis I patients. (15639191)	Fuller M.... Meikle P.J.	2005	IDUA
18	Mucopolysaccharidosis IVA: identification of mutations and methylation study in GALNS gene. (15235041)	Tomatsu S.... Noguchi A.	2004	GALNS
19	Retrovirally transduced bone marrow has a therapeutic effect on brain in the mouse model of mucopolysaccharidosis IIIB. (15308126)	Zheng Y.... Neufeld E.F.	2004	NAGLU
20	Mucopolysaccharidosis VII: clinical, biochemical and molecular investigation of a Brazilian family. (12859417)	Schwartz I.... Giugliani R.	2003	GUSB
21	Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy. (12649061)	Auclair D.... Crawley A.C.	2003	ARSB
22	Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. (12904606)	Strauch O.F.... Peters C.	2003	ARSB
23	The alpha-L-iduronidase mutations R89Q and R89W result in an attenuated mucopolysaccharidosis type I clinical presentation. (14559116)	Hein L.K.... Brooks D.A.	2003	IDUA
24	Transduction of hepatocytes after neonatal delivery of a Moloney murine leukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs. (11829521)	Xu L.... Ponder K.P.	2002	GUSB
25	Molecular analysis of the alpha-N-acetylglucosaminidase gene in seven Japanese patients from six unrelated families with mucopolysaccharidosis IIIB (Sanfilippo type B), including two novel mutations. (12202988)	Tanaka A.... Yamano T.	2002	NAGLU
26	Molecular analysis of 40 Italian patients with mucopolysaccharidosis type II: New mutations in the iduronate-2-sulfatase (IDS) gene. (11462244)	Filocamo M.... Gatti R.	2001	IDS
27	Mucopolysaccharidosis type VI: report of two Taiwanese patients and identification of one novel mutation. (11802522)	Yang C.-F.... Tsai F.-J.	2001	ARSB
28	In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of beta-glucuronidase can delay onset of clinical signs. (11238101)	Casal M.L.... Wolfe J.H.	2001	GUSB
29	Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in mucopolysaccharidosis type VII mice. (11237670)	Kosuga M.... Okuyama T.	2001	GUSB
30	In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors. (11407898)	Stein C.S.... McCray P.B.	2001	GUSB
31	Adenovirus-mediated gene therapy for mucopolysaccharidosis VII: involvement of cross-correction in wide-spread distribution of the gene products and long-term effects of CTLA-4Ig coexpression. (10933961)	Kosuga M.... Okuyama T.	2000	GUSB
32	Sanfilippo type B syndrome (mucopolysaccharidosis III B): allelic heterogeneity corresponds to the wide spectrum of clinical phenotypes. (10094189)	Weber B.... Hopwood J.J.	1999	NAGLU
33	Molecular basis of iduronate-2-sulphatase gene mutations in patients with mucopolysaccharidosis type II (Hunter syndrome). (9950361)	Li P.... Thompson J.N.	1999	IDS
34	Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains. (10446806)	Ginsberg S.D.... Trojanowski J.Q.	1999	APP, MAPT
35	Mucopolysaccharidosis type II: identification of six novel mutations in Italian patients. (9222763)	Villani G.R.D.... Di Natale P.	1997	IDS
36	Fourteen novel mucopolysaccharidosis IVA producing mutations in GALNS gene. (9375852)	Tomatsu S.... Orii T.	1997	GALNS
37	A novel common missense mutation G301C in the N-acetylgalactosamine-6-sulfate sulfatase gene in mucopolysaccharidosis IVA. (9385378)	Kato Z.... Kondo N.	1997	GALNS
38	Arylsulfatase B activities and glycosaminoglycan levels in retrovirally transduced mucopolysaccharidosis type VI cells. Prospects for gene therapy. (8755662)	Fillat C.... Schuchman E.H.	1996	ARSB
39	N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI. (8541342)	Simonaro C.M.... Schuchman E.H.	1995	ARSB, ARSH
40	Mucopolysaccharidosis IVA: polymorphic haplotypes and informative RFLPs in the Japanese population. (7532616)	Iwata H.... Sukegawa K.	1995	GALNS
41	Morphological alterations in dental and periodontal tissues in murine mucopolysaccharidosis type VII. (8574933)	Gritli-Linde A.... Goldberg M.	1995	GUSB, DSPP
42	Mucopolysaccharidosis IV A: molecular cloning of the human N-acetylgalactosamine-6-sulfatase gene (GALNS) and analysis of the 5'-flanking region. (8020961)	Nakashima Y.... Orii T.	1994	GALNS
43	Mucopolysaccharidosis type I: identification of 8 novel mutations and determination of the frequency of the two common alpha-L-iduronidase mutations (W402X and Q70X) among European patients. (7951228)	Bunge S.... Gal A.	1994	IDUA
44	Molecular basis of mucopolysaccharidosis type II: mutations in the iduronate-2-sulphatase gene. (8111411)	Hopwood J.J.... Gal A.	1993	IDS
45	Mucopolysaccharidosis type II (Hunter disease): 13 gene mutations in 52 Japanese patients and carrier detection in four families. (8370574)	Yamada Y.... Orii T.	1993	IDS
46	Caveat to genotype-phenotype correlation in mucopolysaccharidosis type II: discordant clinical severity of R468W and R468Q mutations of the iduronate-2-sulfatase gene. (8364592)	Whitley C.B.... Warburton D.	1993	IDS
47	Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I. (1339393)	Menon K.P.... Neufeld E.F.	1992	IDUA
48	Correction of mucopolysaccharidosis type I fibroblasts by retroviral-mediated transfer of the human alpha-L-iduronidase gene. (1525210)	Anson D.S.... Hopwood J.J.	1992	IDUA
49	Mucopolysaccharidosis type VI: identification of three mutations in the arylsulfatase B gene of patients with the severe and mild phenotypes provides molecular evidence for genetic heterogeneity. (1550123)	Jin W.-D.... Schuchman E.H.	1992	ARSB
50	Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity. (1702266)	Tomatsu S.... Orii T.	1991	GUSB

Genes related to mucopolysaccharidosis according to GeneCards:

(show top 50)    (show all 55)

id	Symbol	Description	Score	GeneCards Section Context
1	IDUA	iduronidase, alpha-L-	11.1	Publications, Summaries
2	GNS	glucosamine (N-acetyl)-6-sulfatase	11.1	Publications, Summaries
3	IDS	iduronate 2-sulfatase	11.1	Publications, Summaries
4	GUSB	glucuronidase, beta	11.1	Summaries, Publications
5	ARSB	arylsulfatase B	11.1	Orthologs, Summaries, Publications
6	NAGLU	N-acetylglucosaminidase, alpha	11.1	Orthologs, Summaries, Publications
7	HYAL1	hyaluronoglucosaminidase 1	11.1	Publications, Orthologs, Summaries
8	SGSH	N-sulfoglucosamine sulfohydrolase	11.1	Publications, Aliases & Descriptions
9	HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase	11.0	Publications
10	GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase	11.0	Publications
11	ARSH	arylsulfatase family, member H	11.0	Publications
12	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
13	HYAL3	hyaluronoglucosaminidase 3	11.0	Publications, Orthologs
14	HYAL2	hyaluronoglucosaminidase 2	11.0	Orthologs, Publications
15	HYAL4	hyaluronoglucosaminidase 4	11.0	Orthologs
16	SPAM1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	11.0	Publications, Orthologs
17	M6PR	mannose-6-phosphate receptor (cation dependent)	11.0	Publications
18	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
19	CRTAP	cartilage associated protein	11.0
20	OR52E6	olfactory receptor, family 52, subfamily E, member 6	11.0
21	LGSN	lengsin, lens protein with glutamine synthetase domain	11.0
22	HEXB	hexosaminidase B (beta polypeptide)	11.0	Publications
23	APRT	adenine phosphoribosyltransferase	11.0	Publications
24	HEXA	hexosaminidase A (alpha polypeptide)	11.0	Publications
25	ALAS2	aminolevulinate, delta-, synthase 2	11.0
26	GLA	galactosidase, alpha	11.0	Publications
27	GLB1	galactosidase, beta 1	11.0
28	EXOC1	exocyst complex component 1	11.0
29	ELN	elastin	11.0	Publications
30	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
31	EEF1A1P6	eukaryotic translation elongation factor 1 alpha 1 pseudogene 6	11.0	Disorders
32	SMA5	glucuronidase, beta pseudogene	11.0	Publications
33	ARSI	arylsulfatase family, member I	11.0	Orthologs
34	GUSBP4	glucuronidase, beta pseudogene 4	11.0	Publications
35	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	11.0	Publications
36	ZSCAN1	zinc finger and SCAN domain containing 1	11.0	Disorders
37	ASB2	ankyrin repeat and SOCS box containing 2	11.0	Disorders
38	ARSE	arylsulfatase E (chondrodysplasia punctata 1)	11.0
39	ARSA	arylsulfatase A	11.0	Publications
40	XYLT2	xylosyltransferase II	11.0	Disorders
41	ARSJ	arylsulfatase family, member J	11.0	Orthologs
42	ARSD	arylsulfatase D	11.0
43	GOLGA2	golgin A2	11.0	Disorders
44	GUSBP2	glucuronidase, beta pseudogene 2	11.0	Publications
45	EDEM3	ER degradation enhancer, mannosidase alpha-like 3	11.0	Disorders
46	SUMF1	sulfatase modifying factor 1	11.0
47	ARMC9	armadillo repeat containing 9	11.0	Disorders
48	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	11.0	Disorders
49	GAA	glucosidase, alpha; acid	11.0
50	GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	11.0

Pathways related to mucopolysaccharidosis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	CS/DS degradation38	10.1	HEXB, HEXA, HYAL1, IDUA, IDS, ARSB
2	Glycosphingolipid biosynthesis - globo series20	10.1	GLA, HEXA, HEXB
3	Glycosphingolipid biosynthesis - ganglio series20	10.0	HEXB, HEXA, GLB1
4	MPS IIIC - Sanfilippo syndrome C38	9.9	GALNS, HGSNAT, GLB1, GNS, HYAL2, GUSB
5	Galactose metabolism20	9.8	GLA, GLB1, GAA
6	Other glycan degradation20	9.8	GLB1, HEXA, HEXB
7	Glycosaminoglycan degradation20	9.3	GALNS, SGSH, NAGLU, GUSB, ARSB, IDS
8	Metabolism of lipids and lipoproteins38	8.9	SUMF1, GLA, ARSA, ARSE, ARSI, ARSH
9	Lysosome20	8.3	GAA, GALNS, SGSH, NAGLU, NAGPA, GUSB
10	Metabolic pathways20	7.9	ALAS2, GNS, GLB1, SPAM1, HEXA, HEXB

Compounds related to mucopolysaccharidosis according to GeneDecks:

(show top 50)    (show all 64)

id	Compound	Score	Top Affiliating Genes
1	(z)-pugnac42	10.7	HEXB, NAGLU
2	glucuronic acid32	10.5	GALNS, HEXA, ARSH, GUSB
3	iduronic acid32 18	11.4	FGF2, IDS, IDUA
4	mucopolysaccharide32	10.4	IDUA, IDS, ARSB, ARSA, ARSH
5	n-acetylgalactosamine 6-sulfate32	10.4	GALNS, APRT, ARSA, ARSH
6	N-Acetyl-D-glucosamine9 18 9	12.4	HEXB, HEXA, NAGPA, NAGLU
7	cerebroside32	10.3	HEXA, GLA, ARSB, ARSA, ARSH
8	chondroitin32 18	11.3	GALNS, GLB1, ARSB, XYLT2
9	dermatan32 18	11.3	ELN, IDUA, IDS, ARSB, GUSB, XYLT2
10	deae-cellulose32	10.3	NAGLU, HEXA, HEXB
11	dermatan sulfate32	10.3	GALNS, ELN, IDUA, IDS, FGF2, ARSB
12	formylglycine32	10.2	SUMF1, ARSB, ARSA, ARSH
13	hyaluronic acid32 18	11.1	GALNS, ELN, SPAM1, HYAL2, HYAL1, FGF2
14	p-nitrocatechol sulfate32	10.1	ARSH, ARSA
15	mannitol32 9 9	12.1	ELN, GLA, FGF2, GUSB, NAGLU
16	n-acetylglucosamine32	10.0	HEXB, HEXA, GNS, ARSB, ARSA, NAGPA
17	trichloroacetic acid32	10.0	DSPP, ELN, NAGLU
18	chondroitin sulfate32 18	11.0	GALNS, ELN, GLB1, HYAL1, FGF2, ARSB
19	g(m2) ganglioside32	9.9	HEXA, HEXB
20	lactose32 9 9	11.9	FGF2, GLA, GLB1, ELN
21	gelfoam32	9.9	FGF2, MAPT, ELN
22	promegestone32	9.8	ARSH, IGF2, HSD17B13
23	polyglycolic acid32	9.7	DSPP, ELN, FGF2
24	polysaccharide32	9.6	GAA, GALNS, ELN, M6PR, IDUA, FGF2
25	ganglioside32	9.6	HEXB, HEXA, GLB1, GLA, IDUA, APP
26	dhea32	9.5	HSD17B13, IGF2, ARSA, ARSH, LCAT
27	estrone sulfate32 18	10.4	HSD17B13, IGF2, ARSE, ARSH, ARSD
28	glucosamine32 9 18 9	12.4	GALNS, IGF2, FGF2, ARSH
29	sodium dodecylsulfate32	9.2	ELN, MAPT, APP, FGF2, LCAT
30	estrone32 9 18 9	12.1	HSD17B13, IGF2, ARSB, ARSA, ARSE, ARSH
31	suramin32 9 9	10.9	ADA, ELN, IGF2, FGF2, ARSA
32	sulfate32 18	9.9	IGF2, IDS, IDUA, GNS, GALNS, ARSB
33	heparan sulfate32 18	9.8	IDS, MAPT, FGF2, ARSA, ARSH, XYLT2
34	mannose32	8.7	GAA, HEXB, HEXA, M6PR, GLA, IDUA
35	lipid32	8.7	GAA, HEXA, SPAM1, M6PR, GLA, HSD17B13
36	glycosaminoglycan32	8.7	GALNS, ELN, SPAM1, IDUA, IDS, IGF2
37	mannose 6-phosphate32 18	9.6	GAA, NAGLU, NAGPA, GUSB, HEXB, HEXA
38	butyrate32	8.5	ALAS2, IGF2, MAPT, APP, ARSH, GUSB
39	valine32	8.3	ELN, GLA, IGF2, MAPT, APP, ARSA
40	heparin32 9 18 9	11.1	IGF2, IDUA, ELN, HEXA, GALNS, MAPT
41	calcium32 9 18 9	11.0	GNS, GLA, SUMF1, SPAM1, ELN, DSPP
42	aspartate32	7.9	GALNS, ADA, DSPP, ELN, GLA, ALAS2
43	formate32	7.8	ADA, DSPP, ELN, IGF2, MAPT, APP
44	lactate32	7.3	GAA, ADA, DSPP, ELN, SPAM1, GLA
45	h2o232	7.2	ADA, DSPP, ELN, IGF2, MAPT, APRT
46	creatinine32	7.2	GAA, ADA, ELN, GLA, HSD17B13, IGF2
47	alanine32	7.1	ADA, DSPP, ELN, ALAS2, IGF2, MAPT
48	serine32	6.9	GLA, M6PR, ELN, HEXA, DSPP, GALNS
49	arginine32	6.8	ELN, DSPP, ADA, GALNS, GAA, M6PR
50	cysteine32	6.7	M6PR, SUMF1, ELN, DSPP, ADA, GALNS

Cellular components related to mucopolysaccharidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lysosomal lumen	GO:043202	9.0	SGSH, GALNS, HEXB, HEXA, GLB1, GLA
2	lysosome	GO:005764	8.7	ADA, GLA, HYAL3, HYAL2, HYAL1, ARSB
3	endoplasmic reticulum lumen	GO:005788	8.3	EDEM3, CRTAP, SUMF1, ARSB, ARSA, ARSE

Biological processes related to mucopolysaccharidosis according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to UV-B	GO:071493	10.3	HYAL3, HYAL2, HYAL1
2	chondroitin sulfate catabolic process	GO:030207	10.2	HEXB, HEXA, HYAL1, IDUA, IDS, ARSB
3	ganglioside catabolic process	GO:006689	10.2	HEXA, HEXB
4	hyaluronan metabolic process	GO:030212	10.2	HEXB, HEXA, HYAL2, HYAL1, GUSB
5	keratan sulfate catabolic process	GO:042340	10.2	GALNS, HEXB, HEXA, GLB1, GNS
6	chondroitin sulfate metabolic process	GO:030204	10.2	HEXB, HEXA, HYAL1, IDUA, IDS, ARSB
7	negative regulation of fibroblast migration	GO:010764	10.1	FGF2, HYAL2
8	keratan sulfate metabolic process	GO:042339	10.1	GALNS, HEXB, HEXA, GLB1, GNS
9	hyaluronan catabolic process	GO:030214	10.1	HEXB, HEXA, HYAL3, HYAL2, HYAL1, FGF2
10	glycosaminoglycan catabolic process	GO:006027	10.0	SGSH, NAGLU, GUSB, IDS, IDUA, HYAL2
11	response to antibiotic	GO:046677	9.9	HYAL1, HYAL2, HYAL3
12	lysosome organization	GO:007040	9.8	GAA, HEXB, HEXA, ARSB, NAGPA
13	glycosaminoglycan metabolic process	GO:030203	9.7	ARSB, GALNS, IDS, IDUA, HYAL1, HYAL2
14	carbohydrate metabolic process	GO:005975	9.3	GLB1, SPAM1, HEXA, HEXB, HGSNAT, GALNS
15	post-translational protein modification	GO:043687	8.9	EDEM3, SUMF1, ARSB, ARSA, ARSE, ARSI
16	sphingolipid metabolic process	GO:006665	8.8	ARSJ, ARSH, ARSI, ARSE, ARSA, ARSB
17	glycosphingolipid metabolic process	GO:006687	8.8	ARSD, HEXB, HEXA, ARSJ, ARSH, ARSI
18	skeletal system development	GO:001501	8.7	DSPP, HEXB, HEXA, IGF2, ARSE
19	cellular protein metabolic process	GO:044267	8.7	HEXB, EDEM3, SUMF1, ARSB, ARSA, ARSE
20	phospholipid metabolic process	GO:006644	8.7	GLA, GLB1, SUMF1, HEXA, HEXB, ARSB
21	small molecule metabolic process	GO:044281	7.3	SGSH, IDS, IDUA, HYAL1, HYAL2, ALAS2

Molecular functions related to mucopolysaccharidosis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	viral receptor activity	GO:001618	10.3	HYAL3, HYAL2, HYAL1
2	hyaluronoglucuronidase activity	GO:033906	10.3	HYAL3, HYAL2
3	hyalurononglucosaminidase activity	GO:004415	10.2	SPAM1, HYAL4, HYAL3, HYAL2, HYAL1
4	N-acetylgalactosamine-4-sulfatase activity	GO:003943	10.2	GALNS, ARSB
5	galactoside binding	GO:016936	10.2	GLA, GLB1
6	sulfuric ester hydrolase activity	GO:008484	10.2	SGSH, ARSA, GNS, GALNS
7	cation binding	GO:043169	10.0	HEXB, HEXA, GLB1, GLA, IDUA, GUSB
8	beta-N-acetylhexosaminidase activity	GO:004563	9.9	HEXA, HEXB
9	arylsulfatase activity	GO:004065	9.5	ARSD, ARSJ, ARSH, ARSI, ARSE, ARSA
10	metal ion binding	GO:046872	9.0	GALNS, SUMF1, GNS, IDS, ARSB, ARSE