MCID: MLT016
MIFTS: 51

Multicentric Reticulohistiocytosis malady

Rare diseases, Bone diseases, Skin diseases categories

Aliases & Classifications for Multicentric Reticulohistiocytosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet, 25ICD10
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Multicentric Reticulohistiocytosis, Aliases & Descriptions:

Name: Multicentric Reticulohistiocytosis 9 41 11 47
Lipoid Dermatoarthritis 9 41 47 60
 
Giant Cell Histiocytomatosis 41 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

47
multicentric reticulohistiocytosis:
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology9 DOID:11824
NCIt38 C27896
Orphanet47 139436
SNOMED-CT55 190801003, 84241008
ICD10 via Orphanet26 D76.3
ICD1025 M14.3

Summaries for Multicentric Reticulohistiocytosis

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NIH Rare Diseases:41 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards based summary: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to arthritis and psoriatic arthritis, and has symptoms including abnormality of the oral cavity, abnormality of the skin and arthritis. An important gene associated with Multicentric Reticulohistiocytosis is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds hcc-1 and tartrate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are no phenotypic analysis and limbs/digits/tail.

Disease Ontology:9 A rare systemic granulomatous syndrome characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia:63 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years... more...

Related Diseases for Multicentric Reticulohistiocytosis

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Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.1TNFSF11, TNF
2psoriatic arthritis29.9TNFRSF11B, TNFSF11, TNF
3arthropathy29.9TNFRSF11B, TNFSF11, TNF
4rheumatoid arthritis29.6CD68, TNFSF11, TNF, CSF1, HAVCR1, TNFRSF11B
5melanoma29.5TNFRSF11B, CSF1, TNFSF11, TNF, CD68
6osteoarthritis29.3CD68, CSF1, TNFRSF11B, TNFSF11, TNF
7dermatomyositis10.5
8pigmented villonodular synovitis10.4CSF1
9blau syndrome10.4TNF
10malignant histiocytosis10.4CSF1
11skin disease10.4CD68
12periodontitis10.3TNFRSF11B
13leprosy10.3
14granuloma annulare10.3
15lepromatous leprosy10.3
16periapical granuloma10.3TNFSF11
17histiocytosis10.3CD68, HAVCR1
18cutaneous fibrous histiocytoma10.2HAVCR1, CD68
19cherubism10.2TNFSF11
20langerhans-cell histiocytosis10.2CSF1, CD68
21systemic lupus erythematosus10.2
22burkitt lymphoma10.2
23nasopharyngeal carcinoma10.2
24myelofibrosis10.2
25primary biliary cirrhosis10.2
26pulmonary fibrosis10.2
27hydrarthrosis10.2
28nasopharyngitis10.2
29ganglioneuroma10.2
30gout10.2
31adenocarcinoma10.2
32dermatitis10.2
33lupus erythematosus10.2
34myopathy10.2
35myositis10.2
36neurofibroma10.2
37pericardial effusion10.2
38spondylitis10.2
39thyroiditis10.2
40tuberculosis10.2
41xanthomatosis10.2
42lupus nephritis10.2
43dysphagia10.2
44myotonia10.2
45nephritis10.2
46mesothelioma10.2
47monocytic leukemia10.0CSF1, TNF
48atopic dermatitis10.0HAVCR1, TNF
49giant cell tumor10.0CSF1, TNFSF11
50hypersensitivity reaction type ii disease10.0TNF, CD68

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Symptoms for Multicentric Reticulohistiocytosis

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Symptoms:

 47
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • arthritis/synovitis/synovial proliferation
  • muscle weakness/flaccidity
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • fever/chilling

HPO human phenotypes related to Multicentric Reticulohistiocytosis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 abnormality of the skin hallmark (90%) HP:0000951
3 arthritis hallmark (90%) HP:0001369
4 muscle weakness occasional (7.5%) HP:0001324
5 decreased body weight occasional (7.5%) HP:0004325
6 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

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Drug clinical trials:

Search ClinicalTrials for Multicentric Reticulohistiocytosis

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

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Anatomical Context for Multicentric Reticulohistiocytosis

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MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

31
Skin, Bone, Liver, Thyroid, Salivary gland, Bone marrow, Eye, Heart, Kidney, Lung, Breast, Cervix, Monocytes, T cells

Animal Models for Multicentric Reticulohistiocytosis or affiliated genes

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MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD68, CSF1, TNFSF11, TNF
2MP:00053718.0CSF1, TNFRSF11B, TNFSF11, TNF
3MP:00053827.8TNF, TNFSF11, TNFRSF11B, CSF1
4MP:00053907.5TNF, TNFSF11, TNFRSF11B, CSF1, CD68
5MP:00053977.2CD68, CSF1, TNFRSF11B, TNFSF11, TNF, HAVCR1
6MP:00053877.2HAVCR1, TNF, TNFSF11, TNFRSF11B, CSF1, CD68

Publications for Multicentric Reticulohistiocytosis

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Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. (23219024)
2013
2
Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. (23555066)
2013
3
Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. (22949898)
2012
4
Multicentric reticulohistiocytosis with elevated cytokine serum levels. (21658110)
2011
5
Multicentric reticulohistiocytosis. (23130232)
2011
6
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. (22070706)
2011
7
Paraneoplastic multicentric reticulohistiocytosis: a clinicopathologic challenge. (21508571)
2011
8
Multicentric reticulohistiocytosis successfully treated with infliximab: an illustrative case and evaluation of cytokine expression supporting anti-tumor necrosis factor therapy. (18936400)
2008
9
Multiple pink papules in the setting of arthritis and fever. Multicentric reticulohistiocytosis (MRH). (18936405)
2008
10
Multicentric reticulohistiocytosis: a systemic osteoclastic disease? (18311766)
2008
11
Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. (18792542)
2008
12
Multicentric reticulohistiocytosis-mimicking dermatomyositis. Case report and review of the literature. (17377390)
2007
13
Multicentric reticulohistiocytosis with positive anticyclic citrullinated antibodies. (17595939)
2007
14
A case of multicentric reticulohistiocytosis with multiple lytic skull lesions. (16045682)
2005
15
Alleviation of polyarticular syndrome in multicentric reticulohistiocytosis with intravenous zoledronate. (16162909)
2005
16
Refractory multicentric reticulohistiocytosis treated by infliximab: two cases. (15789895)
2005
17
Multicentric reticulohistiocytosis with generalized systemic involvement. (15245533)
2004
18
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
19
Multicentric reticulohistiocytosis treated successfully with an anti-tumor necrosis factor agent: comment on the article by Gorman et al. (12632456)
2003
20
Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints. (12006317)
2002
21
Multicentric reticulohistiocytosis in a 14-year-old girl. (12437557)
2002
22
Multicentric reticulohistiocytosis associated with SjAPgren's syndrome. (10971349)
2000
23
Multicentric reticulohistiocytosis in a child: radiologic findings and clinical correlation. (9879265)
1998
24
Atypical multicentric reticulohistiocytosis. (20921740)
1998
25
A case of multicentric reticulohistiocytosis, systemic sclerosis and SjAPgren syndrome. (9301147)
1997
26
Severe multicentric reticulohistiocytosis: disease stabilization achieved with methotrexate and hydroxychloroquine. (9375893)
1997
27
Upper airway involvement in multicentric reticulohistiocytosis. (8643284)
1996
28
Multicentric reticulohistiocytosis. (8929779)
1996
29
Unusual immunocytochemical and ultrastructural features of synovial fluid cells in multicentric reticulohistiocytosis. A case report. (8042427)
1994
30
Unusual digital nodules. Multicentric reticulohistiocytosis (MRH). (1599279)
1992
31
Close temporal and anatomic relationship between multicentric reticulohistiocytosis and carcinoma of the breast. (1629839)
1992
32
Methotrexate treatment of multicentric reticulohistiocytosis. (2066959)
1991
33
Multicentric reticulohistiocytosis accompanied by oral and temporomandibular joint manifestations. (3025389)
1987
34
A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T-cell marker characteristics. (3491619)
1986
35
A case of multicentric reticulohistiocytosis with thyroid involvement. (3771858)
1986
36
A mesothelioma presenting with multicentric reticulohistiocytosis. (3991408)
1985
37
Multicentric reticulohistiocytosis and SjAPgren's syndrome. (4093930)
1985
38
Topical nitrogen mustard therapy in multicentric reticulohistiocytosis. (7061747)
1982
39
Collagen phagocytosis in multicentric reticulohistiocytosis. (7229425)
1981
40
Multicentric reticulohistiocytosis with carcinoma-in-situ of the cervix. (465344)
1979
41
Multicentric reticulohistiocytosis and malignant disease. (204325)
1978
42
Relationship between multicentric reticulohistiocytosis and tuberculosis. (404438)
1977
43
Cardiopulmonary complications in multicentric reticulohistiocytosis. Report of a case. (133639)
1976
44
Multicentric reticulohistiocytosis with ovarian carcinoma. (1273092)
1976
45
Multicentric reticulohistiocytosis (lipoid dermatoarthritis). A multisystem disorder. (5030179)
1972
46
Multicentric reticulohistiocytosis. (5797976)
1969
47
Multicentric reticulohistiocytosis. Report of a case with histochemical studies. (4296608)
1968
48
Myositis and myotonia in a case of multicentric reticulohistiocytosis. (5635595)
1968
49
The nails in multicentric reticulohistiocytosis. (Lipoid dermato-arthritis). (6018996)
1967
50
A STUDY OF MULTICENTRIC RETICULOHISTIOCYTOSIS. (14122094)
1964

Variations for Multicentric Reticulohistiocytosis

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Expression for genes affiliated with Multicentric Reticulohistiocytosis

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Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

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Pathways related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TNFRSF11B, TNFSF11
29.3TNFRSF11B, TNFSF11
3
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.3TNFSF11, TNFRSF11B
49.2CSF1, TNF
59.2TNF, CSF1
69.2CSF1, TNF
79.2TNF, CSF1
8
Show member pathways
Serotonin Transporter Activity36
9.1TNF, TNFRSF11B
9
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1TNF, TNFRSF11B
10
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.0TNFSF11, TNF
119.0TNF, TNFSF11
129.0TNFSF11, TNF
138.7CD68, TNF, CSF1
148.6TNF, CSF1, TNFSF11
15
Show member pathways
8.6TNFSF11, TNF, CSF1
16
Show member pathways
8.6TNFSF11, CSF1, TNF
178.5TNFRSF11B, TNF, TNFSF11
18
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.5TNFSF11, TNFRSF11B, TNF
19
Show member pathways
8.5TNFRSF11B, TNF, TNFSF11
20
Show member pathways
8.5TNFSF11, TNF, TNFRSF11B
21
Show member pathways
8.1TNF, CSF1, TNFRSF11B, TNFSF11
228.1TNFRSF11B, TNFSF11, TNF, CSF1

Compounds for genes affiliated with Multicentric Reticulohistiocytosis

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Compounds related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1hcc-1439.8TNFRSF11B, TNFSF11
2tartrate439.8TNFSF11, CSF1
3denosumab43 1210.7TNFSF11, TNFRSF11B
4teriparatide43 1210.7TNFSF11, TNFRSF11B
5polyethylene439.7TNFRSF11B, TNFSF11
6ibandronate43 1210.7TNFSF11, TNFRSF11B
7pamidronate43 49 1211.7TNFSF11, TNFRSF11B
8risedronate43 49 28 59 1213.7TNFSF11, TNFRSF11B
9clodronate43 49 1211.7TNFRSF11B, TNFSF11
10pmma439.6TNFSF11, TNFRSF11B
11geranylgeranyl pyrophosphate439.6TNFRSF11B, TNFSF11
12titanium439.6TNFRSF11B, TNFSF11
13deoxypyridinoline439.6TNFSF11, TNFRSF11B
14zoledronic acid439.5TNFSF11, TNFRSF11B
15anakinra43 1210.5TNF, TNFRSF11B
16alendronate43 49 1211.4TNFRSF11B, TNFSF11
17lenalidomide43 1210.4TNF, TNFSF11
18mip 1alpha439.4TNFSF11, TNF
19vitamin k2439.3TNFRSF11B, CSF1, TNFSF11
20celecoxib43 59 28 49 24 1214.3CSF1, TNFRSF11B, TNFSF11
21gp 130439.3TNFRSF11B, TNFSF11, CSF1
221,25 dihydroxy vitamin d3439.3TNFRSF11B, TNFSF11, CSF1
23gm-csf43 2810.2TNF, CSF1
24leflunomide43 49 1211.2TNF, TNFSF11
25ascorbic acid43 2410.2CSF1, TNFRSF11B, TNFSF11
26budesonide43 49 1211.1CSF1, TNF
27prednisolone43 28 1211.1TNF, TNFRSF11B, CSF1
28tgf beta1439.1CSF1, TNF, TNFRSF11B
29doxorubicin43 49 1211.1TNFSF11, TNFRSF11B, CSF1
30polymyxin b439.0TNF, TNFSF11, TNFRSF11B
31infliximab43 49 1210.9TNFSF11, TNF, TNFRSF11B
32sulfasalazine28 43 49 1211.9TNF, CSF1
33n acetylcysteine438.9TNF, TNFSF11, CSF1
34paraffin438.9CSF1, CD68, TNFSF11
35methotrexate49 43 1210.9TNFRSF11B, TNFSF11, TNF
36pd 98,059438.8CSF1, TNFSF11, TNF
37sb 20358043 599.8TNF, TNFSF11, TNFRSF11B
38ns 39843 599.5TNF, TNFSF11, TNFRSF11B, CSF1
39etanercept43 49 1210.5TNF, CSF1, TNFRSF11B, TNFSF11
40prostaglandin438.5TNFRSF11B, CSF1, TNFSF11, TNF
41calcitriol43 59 24 1211.5TNFRSF11B, TNF, CSF1, TNFSF11
42rantes438.5TNFRSF11B, TNF, CSF1, TNFSF11
43indomethacin43 28 59 1211.5CSF1, TNFRSF11B, TNFSF11, TNF
44ly294002438.5TNF, TNFSF11, CSF1, TNFRSF11B
45genistein43 28 59 2 24 1213.5CSF1, TNFRSF11B, TNFSF11, TNF
46pge2438.5TNFSF11, TNF, CSF1, TNFRSF11B
47cycloheximide438.5CSF1, TNF, TNFSF11, TNFRSF11B
48dexamethasone43 49 28 1211.4TNFSF11, CSF1, TNF, TNFRSF11B
49vegf438.4TNFSF11, CSF1, TNF, TNFRSF11B
50lipid438.1CD68, TNFRSF11B, TNF, TNFSF11

GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

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Cellular components related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1CSF1, TNFRSF11B, TNFSF11, TNF

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00021589.6TNFSF11, CSF1
2ossificationGO:00015039.5CSF1, TNFSF11
3tumor necrosis factor-mediated signaling pathwayGO:00332099.2TNFSF11, TNF
4positive regulation of MAP kinase activityGO:00434069.2TNFSF11, TNF
5positive regulation of JNK cascadeGO:00463309.1TNF, TNFSF11
6positive regulation of protein kinase B signalingGO:00518979.0TNFSF11, TNF
7positive regulation of NF-kappaB transcription factor activityGO:00510929.0TNFSF11, TNF
8organ morphogenesisGO:00098878.9TNF, TNFSF11
9positive regulation of osteoclast differentiationGO:00456728.8CSF1, TNFSF11, TNF
10osteoclast differentiationGO:00303168.8CSF1, TNFSF11, TNF
11positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.7TNFSF11, TNF

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.0TNFSF11, TNF
2cytokine activityGO:00051257.8CSF1, TNFRSF11B, TNFSF11, TNF

Products for genes affiliated with Multicentric Reticulohistiocytosis

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Sources for Multicentric Reticulohistiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet