MCID: MLT016
MIFTS: 55

Multicentric Reticulohistiocytosis malady

Bone diseases, Skin diseases categories

Summaries for Multicentric Reticulohistiocytosis

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to arthritis and rheumatoid arthritis, and has symptoms including enanthema/aphtosa/aphta/leukoplakia, wasted (excluding lipodystrophy)/poorly muscled build/cachexy and follicular/erythematous/edematous papules/milium. An important gene associated with Multicentric Reticulohistiocytosis is LYZ (lysozyme), and among its related pathways are Rheumatoid arthritis and Osteoclast Signaling. The compounds hcc-1 and denosumab have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are skeleton and craniofacial.

Wikipedia:63 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years... more...

Aliases & Classifications for Multicentric Reticulohistiocytosis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

48
multicentric reticulohistiocytosis:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

multicentric reticulohistiocytosis 8 42 10 48
lipoid dermatoarthritis 8 48 60
giant cell histiocytomatosis 48


External Ids:

Disease Ontology8 DOID:11824
NCIt39 C27896
SNOMED-CT56 84241008, 190801003
ICD10 via Orphanet26 D76.3
ICD1025 M14.3

Related Diseases for Multicentric Reticulohistiocytosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Clinical Features for Multicentric Reticulohistiocytosis

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48
  • enanthema/aphtosa/aphta/leukoplakia
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • follicular/erythematous/edematous papules/milium
  • fever/chilling
  • arthritis/synovitis/synovial proliferation
  • muscle weakness/flaccidity

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Multicentric Reticulohistiocytosis

Drug clinical trials:

Search ClinicalTrials for Multicentric Reticulohistiocytosis

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Search CenterWatch for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

About this section

Anatomical Context for Multicentric Reticulohistiocytosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

32
Skin, Bone, Liver, Salivary gland, Lung, Thyroid, Heart, Kidney, Eye, Bone marrow, Breast, Monocytes, T cells, Cervix

Animal Models for Multicentric Reticulohistiocytosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.3CSF1, TNFSF11, TNFRSF11B, CD68
2MP:00053828.1TNF, TNFRSF11B, TNFSF11, CSF1
3MP:00053717.8CSF1, TNFSF11, TNFRSF11B, TNF
4MP:00053977.2CD68, HAVCR1, TNF, TNFRSF11B, TNFSF11, CSF1
5MP:00053877.1CSF1, TNFSF11, TNFRSF11B, TNF, HAVCR1, CD68

Publications for Multicentric Reticulohistiocytosis

About this section
Sources:
50PubMed
See all sources

Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Granuloma annulare mimicking multicentric reticulohistiocytosis. (24314776)
2013
2
Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. (22949898)
2012
3
Overexpression of monocyte chemoattractant protein-1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: a case report. (22435444)
2012
4
Paraneoplastic multicentric reticulohistiocytosis: a clinicopathologic challenge. (21508571)
2011
5
Multicentric reticulohistiocytosis associated arthritis responding to anti-TNF and methotrexate. (21485770)
2011
6
Multicentric reticulohistiocytosis. (20657124)
2010
7
Multicentric reticulohistiocytosis in a Malaysian Chinese lady: a case report and review of literature . (19281707)
2009
8
Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate. (18346261)
2008
9
Multicentric reticulohistiocytosis with positive anticyclic citrullinated antibodies. (17595939)
2007
10
Multicentric reticulohistiocytosis associated with ovarian cancer. (17929137)
2007
11
Multicentric reticulohistiocytosis: a proliferation of macrophages with tropism for skin and joints, part II. (17786100)
2007
12
Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis. (16938523)
2006
13
Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium. (16310073)
2005
14
Multicentric reticulohistiocytosis and pregnancy. (15842296)
2005
15
Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient. (15742455)
2005
16
Multicentric reticulohistiocytosis associated with rheumatoid arthritis. (15765219)
2005
17
Multicentric reticulohistiocytosis. The long course of a rare disease. (12109645)
2002
18
A case of systemic lupus erythematosus complicated with multicentric reticulohistiocytosis (MRH): successful treatment of MRH and lupus nephritis with cyclosporin A. (11237126)
2001
19
Prolonged response of multicentric reticulohistiocytosis to low dose methotrexate. (9598911)
1998
20
Multicentric reticulohistiocytosis associated with recurrent breast carcinoma. (9810917)
1998
21
Case report: the CT demonstration of soft tissue involvement in multicentric reticulohistiocytosis. (8654013)
1996
22
Multicentric reticulohistiocytosis and methotrexate. (7657881)
1995
23
A unique presentation of multicentric reticulohistiocytosis in pregnancy. (8431218)
1993
24
New electron microscopic findings in a case of multicentric reticulohistiocytosis. Long spacing collagen inclusions. (8311193)
1993
25
Multicentric reticulohistiocytosis associated with subclinical SjAPgren's syndrome. (1914422)
1991
26
Multicentric reticulohistiocytosis. Detailed immunophenotyping confirms macrophage origin. (2192569)
1990
27
Multicentric reticulohistiocytosis: response to dexamethasone pulse therapy. (2301968)
1990
28
Multicentric reticulohistiocytosis: response to alkylating agents in six patients. (2764405)
1989
29
Multicentric reticulohistiocytosis in a child with sclerosing lesion of the leg. Immunohistopathologic studies and therapeutic trial with systemic cyclosporine. (2915077)
1989
30
Multicentric reticulohistiocytosis. (3165187)
1988
31
Multicentric reticulohistiocytosis. (3828217)
1987
32
Multicentric reticulohistiocytosis, another lipid disorder with normolipidemic xanthomatosis? (3426652)
1987
33
A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T-cell marker characteristics. (3491619)
1986
34
A case of multicentric reticulohistiocytosis with thyroid involvement. (3771858)
1986
35
A mesothelioma presenting with multicentric reticulohistiocytosis. (3991408)
1985
36
Multicentric reticulohistiocytosis mimicking rheumatoid arthritis. (4085168)
1985
37
Multicentric reticulohistiocytosis. (6386904)
1984
38
Multicentric reticulohistiocytosis with salivary gland involvement and pericardial effusion. (6863627)
1983
39
Multicentric reticulohistiocytosis: a review of eight cases. (7438523)
1980
40
Multicentric reticulohistiocytosis with ovarian carcinoma. (1273092)
1976
41
Multicentric reticulohistiocytosis with extensive bone and joint destruction. (4518826)
1973
42
Multicentric reticulohistiocytosis (lipoid dermatoarthritis). (4739764)
1973
43
Multicentric reticulohistiocytosis (lipoid dermatoarthritis). A multisystem disorder. (5030179)
1972
44
Multicentric reticulohistiocytosis. (5027608)
1972
45
Multicentric reticulohistiocytosis (lipoid dermato-arthritis): a clinical conundrum. (5497371)
1970
46
Multicentric reticulohistiocytosis. (5797976)
1969
47
Multicentric reticulohistiocytosis. Report of a case with histochemical studies. (4296608)
1968
48
Myositis and myotonia in a case of multicentric reticulohistiocytosis. (5635595)
1968
49
The nails in multicentric reticulohistiocytosis. (Lipoid dermato-arthritis). (6018996)
1967
50
Identification of tissue lipids in lipoid dermatoarthritis (multicentric reticulohistiocytosis). (6019208)
1967

Genetic Variations for Multicentric Reticulohistiocytosis

About this section

Expression for genes affiliated with Multicentric Reticulohistiocytosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 52R&D Systems
See all sources

Pathways related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFSF11
29.5TNFRSF11B, TNFSF11
39.5TNFSF11, TNFRSF11B
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.5TNFSF11, TNFRSF11B
59.2TNF, TNFRSF11B
6
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.1TNF, TNFSF11
79.0TNF, CSF1
8
Hide members
8.7TNF, TNFRSF11B, TNFSF11
9
Hide members
8.7TNF, TNFRSF11B, TNFSF11
10
Hide members
8.7TNF, TNFRSF11B, TNFSF11
118.5CD68, TNF, CSF1
12
Hide members
8.1CSF1, TNFSF11, TNFRSF11B, TNF
138.1TNF, TNFRSF11B, TNFSF11, CSF1

Compounds for genes affiliated with Multicentric Reticulohistiocytosis

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1hcc-1449.9TNFRSF11B, TNFSF11
2denosumab44 1110.9TNFSF11, TNFRSF11B
3teriparatide44 1110.9TNFSF11, TNFRSF11B
4ibandronate44 1110.9TNFRSF11B, TNFSF11
5polyethylene449.9TNFRSF11B, TNFSF11
6pamidronate44 49 1111.9TNFRSF11B, TNFSF11
7risedronate44 59 49 28 1113.9TNFRSF11B, TNFSF11
8clodronate44 49 1111.8TNFRSF11B, TNFSF11
9pmma449.8TNFRSF11B, TNFSF11
10geranylgeranyl pyrophosphate449.8TNFRSF11B, TNFSF11
11titanium449.8TNFRSF11B, TNFSF11
12zoledronic acid449.8TNFSF11, TNFRSF11B
13deoxypyridinoline449.7TNFSF11, TNFRSF11B
14alendronate44 49 1111.7TNFSF11, TNFRSF11B
15tartrate449.7CSF1, TNFSF11
16anakinra44 1110.6TNFRSF11B, TNF
17lenalidomide44 1110.5TNF, TNFSF11
18mip 1alpha449.5TNFSF11, TNF
193-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4TNFRSF11B, TNFSF11
20leflunomide49 44 1111.4TNF, TNFSF11
21vitamin k2449.3CSF1, TNFSF11, TNFRSF11B
22celecoxib44 59 28 49 11 2414.3TNFRSF11B, TNFSF11, CSF1
23gp 130449.3TNFRSF11B, TNFSF11, CSF1
241,25 dihydroxy vitamin d3449.3TNFRSF11B, TNFSF11, CSF1
25gm-csf44 2810.2CSF1, TNF
2625-hydroxyvitamin d449.2TNFRSF11B, TNFSF11
27budesonide44 49 1111.2TNF, CSF1
28ascorbic acid44 2410.2TNFRSF11B, TNFSF11, CSF1
29sulfasalazine44 28 49 1112.1TNF, CSF1
30polymyxin b449.1TNFSF11, TNFRSF11B, TNF
31infliximab44 49 1111.1TNFSF11, TNFRSF11B, TNF
32fluticasone propionate44 49 59 1112.1TNF, CSF1
33polyinosinic-polycytidylic acid449.0TNF, CSF1
34methotrexate44 49 1111.0TNF, TNFRSF11B, TNFSF11
35prednisolone44 28 1111.0TNF, TNFRSF11B, CSF1
36tgf beta1449.0TNF, TNFRSF11B, CSF1
37sb 20358044 599.9TNF, TNFRSF11B, TNFSF11
38n acetylcysteine448.8CSF1, TNFSF11, TNF
39pd 98,059448.5CSF1, TNFSF11, TNF
40ns 39844 599.5TNF, TNFRSF11B, TNFSF11, CSF1
41etanercept44 49 1110.5TNF, TNFRSF11B, TNFSF11, CSF1
42prostaglandin448.5TNF, TNFRSF11B, TNFSF11, CSF1
43calcitriol44 59 11 2411.5TNF, TNFRSF11B, TNFSF11, CSF1
44rantes448.5CSF1, TNFSF11, TNFRSF11B, TNF
45indomethacin44 59 28 1111.5TNF, TNFRSF11B, TNFSF11, CSF1
46ly294002448.5TNF, TNFRSF11B, TNFSF11, CSF1
47genistein44 28 59 2 11 2413.5TNF, TNFRSF11B, TNFSF11, CSF1
48pge2448.5CSF1, TNFSF11, TNFRSF11B, TNF
49dexamethasone44 49 28 1111.4CSF1, TNFSF11, TNFRSF11B, TNF
50vegf448.4CSF1, TNFSF11, TNFRSF11B, TNF

GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7LYZ, TNF, TNFRSF11B, TNFSF11, CSF1

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:0021589.4TNFSF11, CSF1
2tumor necrosis factor-mediated signaling pathwayGO:0332099.1TNFSF11, TNF
3positive regulation of JNK cascadeGO:0463309.1TNF, TNFSF11
4positive regulation of MAP kinase activityGO:0434068.8TNF, TNFSF11
5positive regulation of osteoclast differentiationGO:0456728.7TNF, TNFSF11, CSF1
6osteoclast differentiationGO:0303168.6TNF, TNFSF11, CSF1
7inflammatory responseGO:0069548.6LYZ, TNF, CSF1

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1TNF, TNFSF11
2cytokine activityGO:0051257.8TNF, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Multicentric Reticulohistiocytosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multicentric Reticulohistiocytosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet