MCID: MLT016
MIFTS: 46

Multicentric Reticulohistiocytosis

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Multicentric Reticulohistiocytosis

MalaCards integrated aliases for Multicentric Reticulohistiocytosis:

Name: Multicentric Reticulohistiocytosis 12 50 56 14
Lipoid Dermatoarthritis 12 56 69
Giant Cell Histiocytomatosis 56

Characteristics:

Orphanet epidemiological data:

56
multicentric reticulohistiocytosis
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:11824
ICD10 33 E78.81 M14.3
NCIt 47 C27896
SNOMED-CT 64 190801003 84241008
Orphanet 56 ORPHA139436
UMLS via Orphanet 70 C0311284
ICD10 via Orphanet 34 D76.3
UMLS 69 C0311284

Summaries for Multicentric Reticulohistiocytosis

NIH Rare Diseases : 50 multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards based summary : Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to rheumatoid arthritis and aortic aneurysm, and has symptoms including muscle weakness, arthritis and fever. An important gene associated with Multicentric Reticulohistiocytosis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methotrexate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and hematopoietic system

Disease Ontology : 12 A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia : 72 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50... more...

Related Diseases for Multicentric Reticulohistiocytosis

Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 28.7 CSF1 TNFRSF11B TNFSF11
2 aortic aneurysm 10.5 F13A1 VIM
3 noninvasive malignant thymoma 10.4 F13A1 VIM
4 hemangioma 10.4 F13A1 VIM
5 small intestine neuroendocrine neoplasm 10.4 F13A1 VIM
6 juvenile xanthogranuloma 10.4 F13A1 VIM
7 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.4 F13A1 VIM
8 intellectual disability-polydactyly-uncombable hair syndrome 10.4 PTPRC VIM
9 internal hordeolum 10.4 TNFSF11 VIM
10 rhabditida infections 10.4 PTPRC VIM
11 short-rib thoracic dysplasia 12 10.3 PTPRC VIM
12 small cell neuroendocrine carcinoma 10.3 F13A1 VIM
13 ovarian mucinous adenocarcinoma 10.3 PTPRC VIM
14 spondyloepimetaphyseal dysplasia, isidor type 10.3 PTPRC VIM
15 dense deposit disease 10.3 PTPRC VIM
16 malignant adenofibroma 10.3 F13A1 VIM
17 arthritis 10.3
18 cerebrum cancer 10.3 PTPRC VIM
19 dextrocardia with situs inversus 10.3 PTPRC VIM
20 neutrophil immunodeficiency syndrome 10.2 F13A1 VIM
21 serous cystadenocarcinoma 10.2 PTPRC VIM
22 anodontia of permanent dentition 10.2 CSF1 F13A1
23 plasma protein metabolism disease 10.2 CSF1 TNFSF11
24 impotence 10.1 CSF1 TNFSF11
25 dermatomyositis 10.1
26 keloids 10.1 CSF1 TNFSF11
27 nephrolithiasis, calcium oxalate 10.1 CSF1 TNFSF11
28 cervical adenomyoma 10.0 TNFRSF11B VIM
29 polyembryoma 10.0 TNFRSF11B TNFSF11
30 tibial hemimelia 10.0 TNFRSF11B TNFSF11
31 paget disease of bone 2, early-onset 10.0 TNFRSF11B TNFSF11
32 hennekam van der horst syndrome 10.0 TNFRSF11B TNFSF11
33 peripheral scars of retina 10.0 TNFRSF11B TNFSF11
34 spinocerebellar ataxia 4 9.9 TNFRSF11B TNFSF11
35 metaphyseal anadysplasia 2 9.9 TNFRSF11B TNFSF11
36 lower clivus meningioma 9.9 TNFRSF11B TNFSF11
37 bronchus cancer 9.9 TNFRSF11B TNFSF11
38 bacillary angiomatosis 9.9 TNFRSF11B TNFSF11
39 bone resorption disease 9.9 TNFRSF11B TNFSF11
40 glossitis 9.9 TNFRSF11B TNFSF11
41 physical disorder 9.8 TNFRSF11B TNFSF11
42 granuloma annulare 9.8
43 lymphoma 9.8
44 lepromatous leprosy 9.8
45 leprosy 9.8
46 melanoma 9.8
47 bone deterioration disease 9.8 TNFRSF11B TNFSF11
48 ovarian insufficiency, familial 9.8 TNFRSF11B TNFSF11
49 psoriasis susceptibility 1 9.8 TNFRSF11B TNFSF11
50 neuropathy 9.8 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to Multicentric Reticulohistiocytosis

Symptoms & Phenotypes for Multicentric Reticulohistiocytosis

Human phenotypes related to Multicentric Reticulohistiocytosis:

56 32 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscle weakness 56 32 occasional (7.5%) Occasional (29-5%) HP:0001324
2 arthritis 56 32 hallmark (90%) Very frequent (99-80%) HP:0001369
3 fever 56 32 occasional (7.5%) Occasional (29-5%) HP:0001945
4 cachexia 56 32 occasional (7.5%) Occasional (29-5%) HP:0004326
5 skin nodule 56 32 hallmark (90%) Very frequent (99-80%) HP:0200036
6 histiocytosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0100727

GenomeRNAi Phenotypes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.44 CSF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.44 VIM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.44 CSF1 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.44 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.44 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 CSF1 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 VIM
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.44 CSF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 CSF1 TNFSF11 VIM

MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CSF1 F13A1 PTPRC TNFRSF11B TNFSF11 VIM
2 immune system MP:0005387 9.55 TNFRSF11B TNFSF11 VIM CSF1 PTPRC
3 mortality/aging MP:0010768 9.43 CSF1 F13A1 PTPRC TNFRSF11B TNFSF11 VIM
4 respiratory system MP:0005388 9.02 CSF1 F13A1 PTPRC TNFSF11 VIM

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

Drugs for Multicentric Reticulohistiocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
3
Vinblastine Approved Phase 3 865-21-4 13342 241903
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
6 6-Mercaptopurine Phase 3
7 Anti-Inflammatory Agents Phase 3
8 Antimetabolites Phase 3
9 Antimetabolites, Antineoplastic Phase 3
10 Antimitotic Agents Phase 3
11 Antineoplastic Agents, Hormonal Phase 3
12 Antineoplastic Agents, Phytogenic Phase 3
13 Antirheumatic Agents Phase 3
14 Dermatologic Agents Phase 3
15 Folic Acid Antagonists Phase 3
16 glucocorticoids Phase 3
17 Hormone Antagonists Phase 3
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Immunosuppressive Agents Phase 3
21 Nucleic Acid Synthesis Inhibitors Phase 3
22 Vitamin B Complex Phase 3
23 Folate Nutraceutical Phase 3
24 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 H-9926-LCH III: Treatment Protocol of the Third International Study for Langerhans Cell Histiocytosis Completed NCT00488605 Phase 3 Prednisone, Vinblastin, 6-mercaptopuroine;Leucovorin, Methotrexate, Vinblastine, Prednisone
2 Prospective Evaluation of Adult Pulmonary Langerhans Cell Histiocytosis Completed NCT01225601
3 International Rare Histiocytic Disorders Registry (IRHDR) Recruiting NCT02285582

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

Anatomical Context for Multicentric Reticulohistiocytosis

MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

39
Skin, Bone, Liver, Lung, Thyroid, Salivary Gland, Bone Marrow

Publications for Multicentric Reticulohistiocytosis

Articles related to Multicentric Reticulohistiocytosis:

(show top 50) (show all 245)
id Title Authors Year
1
Looks Can Be Deceiving: A Case Report on Multicentric Reticulohistiocytosis Successfully Treated with Rituximab. ( 28589069 )
2017
2
Multicentric reticulohistiocytosis associated with thymic carcinoma. ( 28633354 )
2017
3
Dermoscopic features of periungual papules in multicentric reticulohistiocytosis. ( 28382775 )
2017
4
Multicentric Reticulohistiocytosis: an Unknown Source of Embolic Stroke. ( 27839900 )
2017
5
Multicentric Reticulohistiocytosis with Dermatomyositis-like Eruptions. ( 28768982 )
2017
6
Involvement of M2 macrophages in the pathomechanisms of multicentric reticulohistiocytosis. ( 28556889 )
2017
7
Multicentric Reticulohistiocytosis Mimicking Malignancy on 18F-FDG PET/CT. ( 28368895 )
2017
8
Efficacy of Vinblastine and Prednisone in Multicentric Reticulohistiocytosis With Onset in Infancy. ( 27199388 )
2016
9
Multicentric Reticulohistiocytosis in a 5-Year-Old Girl. ( 27492868 )
2016
10
Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. ( 27175854 )
2016
11
Nailfold Capillary Patterns in a Patient With Multicentric Reticulohistiocytosis and Raynaud Phenomenon. ( 27219314 )
2016
12
Multicentric Reticulohistiocytosis: A Unique Case of Chronic Colitis. ( 27580770 )
2016
13
Multicentric reticulohistiocytosis: Rheumatology perspective. ( 27886798 )
2016
14
Metastatic Inflammatory Breast Cancer Associated With Multicentric Reticulohistiocytosis Successfully Treated With Zoledronic Acid. ( 27435627 )
2016
15
Multicentric reticulohistiocytosis (MRH): case report with review of literature between 1991 and 2014 with in depth analysis of various treatment regimens and outcomes. ( 27026876 )
2016
16
Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. ( 26652057 )
2016
17
Bilateral Total Hip Arthroplasty in a Rare Case of Multicentric Reticulohistiocytosis. ( 26640636 )
2015
18
Multicentric reticulohistiocytosis: a critical review. ( 25900189 )
2015
19
Successful Treatment of Multicentric Reticulohistiocytosis with Adalimumab, Prednisolone and Methotrexate. ( 26072967 )
2015
20
Erythema, papules, and arthralgia associated with liver cancer: report of a rare case of multicentric reticulohistiocytosis. ( 26045857 )
2015
21
Multicentric Reticulohistiocytosis: A Case Report of an Atypical Presentation in a 2-Year-Old. ( 25727569 )
2015
22
18F-FDG PET/CT Findings in Multicentric Reticulohistiocytosis. ( 26571445 )
2015
23
Organizing pneumonia associated with multicentric reticulohistiocytosis. ( 26740877 )
2015
24
Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options. ( 24733253 )
2014
25
Multicentric reticulohistiocytosis can mimic rheumatoid arthritis. ( 24692603 )
2014
26
Multicentric reticulohistiocytosis. ( 25092372 )
2014
27
A case of multicentric reticulohistiocytosis. ( 25211404 )
2014
28
Multicentric reticulohistiocytosis misdiagnosed as rheumatoid arthritis. ( 25040783 )
2014
29
Multicentric reticulohistiocytosis: contrasting presentations in 2 Hispanic patients. ( 24897136 )
2014
30
Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. ( 23555066 )
2013
31
Multicentric reticulohistiocytosis: a rare yet challenging disease. ( 23417597 )
2013
32
Hand surgery for Multicentric Reticulohistiocytosis: A new avenue of treatment and review of the literature. ( 23796955 )
2013
33
Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. ( 23441782 )
2013
34
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. ( 23219024 )
2013
35
Multicentric reticulohistiocytosis with extra-mammillary Paget's disease: a case report. ( 24168966 )
2013
36
Granuloma annulare mimicking multicentric reticulohistiocytosis. ( 24314776 )
2013
37
Multicentric reticulohistiocytosis. ( 22945300 )
2013
38
Treatment of facial lesions of multicentric reticulohistiocytosis by carbon dioxide laser. ( 24163535 )
2013
39
Treatment of multicentric reticulohistiocytosis with tocilizumab. ( 23872542 )
2013
40
Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. ( 22351825 )
2012
41
Multicentric reticulohistiocytosis masquerading as dermatomyositis: similar and different features. ( 21950771 )
2012
42
Leonine facies in the cutaneous form of multicentric reticulohistiocytosis. ( 22864143 )
2012
43
Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. ( 22949898 )
2012
44
Overexpression of monocyte chemoattractant protein-1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: a case report. ( 22435444 )
2012
45
Multicentric reticulohistiocytosis and fibroblastic rheumatism. ( 23040366 )
2012
46
Multicentric reticulohistiocytosis presenting with the cutaneous features of photosensitivity dermatitis. ( 21545508 )
2012
47
Progressive multicentric reticulohistiocytosis. ( 22449693 )
2012
48
Resident rounds. Part III: Multicentric reticulohistiocytosis presenting as granuloma annulare. ( 23547330 )
2012
49
Multicentric reticulohistiocytosis: a rare case report. ( 22837570 )
2012
50
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. ( 22070706 )
2011

Variations for Multicentric Reticulohistiocytosis

Expression for Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for Multicentric Reticulohistiocytosis

GO Terms for Multicentric Reticulohistiocytosis

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase activity GO:0045860 9.26 CSF1 PTPRC
2 osteoclast differentiation GO:0030316 9.16 CSF1 TNFSF11
3 positive regulation of osteoclast differentiation GO:0045672 8.96 CSF1 TNFSF11
4 osteoclast proliferation GO:0002158 8.62 CSF1 TNFSF11

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CSF1 TNFRSF11B TNFSF11

Sources for Multicentric Reticulohistiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....