MCID: MLT016
MIFTS: 55

Multicentric Reticulohistiocytosis malady

Bone diseases, Skin diseases categories

Summaries for Multicentric Reticulohistiocytosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to arthritis and rheumatoid arthritis, and has symptoms including fever/chilling, wasted (excluding lipodystrophy)/poorly muscled build/cachexy and muscle weakness/flaccidity. An important gene associated with Multicentric Reticulohistiocytosis is LYZ (lysozyme), and among its related pathways are Rheumatoid arthritis and Osteoclast Signaling. The compounds hcc-1 and denosumab have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are skeleton and craniofacial.

Wikipedia:63 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years... more...

Aliases & Classifications for Multicentric Reticulohistiocytosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

48
multicentric reticulohistiocytosis:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

multicentric reticulohistiocytosis 8 42 10 48
lipoid dermatoarthritis 8 48 60
giant cell histiocytomatosis 48


External Ids:

Disease Ontology8 DOID:11824
NCIt39 C27896
SNOMED-CT56 84241008, 190801003
ICD10 via Orphanet26 D76.3
ICD1025 M14.3

Related Diseases for Multicentric Reticulohistiocytosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Clinical Features for Multicentric Reticulohistiocytosis

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48Orphanet
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Symptoms:

48
  • fever/chilling
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • muscle weakness/flaccidity
  • arthritis/synovitis/synovial proliferation
  • enanthema/aphtosa/aphta/leukoplakia
  • follicular/erythematous/edematous papules/milium

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Multicentric Reticulohistiocytosis

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Search CenterWatch for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

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Anatomical Context for Multicentric Reticulohistiocytosis

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32MalaCards
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MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

32
Skin, Bone, Liver, Lung, Thyroid, Salivary gland, Heart, Eye, Bone marrow, Kidney, Breast, Cervix, Monocytes, T cells

Animal Models for Multicentric Reticulohistiocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.3CSF1, TNFSF11, TNFRSF11B, CD68
2MP:00053828.1TNF, TNFRSF11B, TNFSF11, CSF1
3MP:00053717.8CSF1, TNFSF11, TNFRSF11B, TNF
4MP:00053977.2CD68, HAVCR1, TNF, TNFRSF11B, TNFSF11, CSF1
5MP:00053877.1CSF1, TNFSF11, TNFRSF11B, TNF, HAVCR1, CD68

Publications for Multicentric Reticulohistiocytosis

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50PubMed
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Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. (23441782)
2013
2
Treatment of facial lesions of multicentric reticulohistiocytosis by carbon dioxide laser. (24163535)
2013
3
Treatment of multicentric reticulohistiocytosis with tocilizumab. (23872542)
2013
4
Multicentric reticulohistiocytosis: a rare case report. (22837570)
2012
5
Multicentric reticulohistiocytosis. (23130232)
2011
6
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. (22070706)
2011
7
Ultraviolet light-induced KAPbner phenomenon contributes to the development of skin eruptions in multicentric reticulohistiocytosis. (21279300)
2011
8
Aberrant expression of CD10 in ground-glass-like multinucleated giant cells of multicentric reticulohistiocytosis. (21039790)
2010
9
Healing of erosive disease in multicentric reticulohistiocytosis. (20516048)
2010
10
Multicentric reticulohistiocytosis: an autoimmune systemic disease? Case report of an association with erosive rheumatoid arthritis and systemic Sjogren syndrome. (20435499)
2010
11
Refractory multicentric reticulohistiocytosis treated by infliximab: two cases. (15789895)
2005
12
Etanercept and the treatment of multicentric reticulohistiocytosis. (16172321)
2005
13
Successful treatment of multicentric reticulohistiocytosis with a combination of infliximab, prednisolone and methotrexate. (15844643)
2004
14
Multicentric reticulohistiocytosis. (15454131)
2004
15
Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. (12582374)
2003
16
Successful treatment of multicentric reticulohistiocytosis with alendronate: evidence for a direct effect of bisphosphonate on histiocytes. (14674006)
2003
17
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. (24383904)
2002
18
Multicentric reticulohistiocytosis. (11843211)
2001
19
Multicentric reticulohistiocytosis associated with SjAPgren's syndrome. (10971349)
2000
20
Multicentric reticulohistiocytosis: case report with immunohistochemical analysis and literature review. (10765941)
2000
21
Multicentric reticulohistiocytosis: a mimic of gout and rheumatoid arthritis. (10079586)
1999
22
Multicentric reticulohistiocytosis in a child: radiologic findings and clinical correlation. (9879265)
1998
23
A case of multicentric reticulohistiocytosis, systemic sclerosis and SjAPgren syndrome. (9301147)
1997
24
Severe multicentric reticulohistiocytosis: disease stabilization achieved with methotrexate and hydroxychloroquine. (9375893)
1997
25
Upper airway involvement in multicentric reticulohistiocytosis. (8643284)
1996
26
Multicentric reticulohistiocytosis. (8929779)
1996
27
Multicentric reticulohistiocytosis. A report of 3 cases and review of literature. (8756156)
1996
28
Multicentric reticulohistiocytosis associated with recurrence of malignant melanoma. (7822508)
1995
29
Reticulohistiocytoma and multicentric reticulohistiocytosis. Histopathologic and immunophenotypic distinct entities. (7864294)
1994
30
Unusual case of multicentric reticulohistiocytosis. (8440555)
1993
31
Multicentric reticulohistiocytosis. (8339183)
1993
32
Unusual digital nodules. Multicentric reticulohistiocytosis (MRH). (1599279)
1992
33
Close temporal and anatomic relationship between multicentric reticulohistiocytosis and carcinoma of the breast. (1629839)
1992
34
Multicentric reticulohistiocytosis. Report of a case with electron microscopic studies. (1561884)
1992
35
Multicentric reticulohistiocytosis. Immunohistological and ultrastructural study: a pathology of dendritic cell lineage. (1415960)
1992
36
The other arthritides. Roentgenologic features of osteoarthritis, erosive osteoarthritis, ankylosing spondylitis, psoriatic arthritis, Reiter's disease, multicentric reticulohistiocytosis, and progressive systemic sclerosis. (3051093)
1988
37
Multicentric reticulohistiocytosis. Report of three cases with the evaluation of tissue proteinase activity. (3146226)
1988
38
Multicentric reticulohistiocytosis accompanied by oral and temporomandibular joint manifestations. (3025389)
1987
39
Multicentric reticulohistiocytosis and cancer: a case report and review of the literature. (2412096)
1985
40
Multicentric reticulohistiocytosis associated with primary biliary cirrhosis: successful treatment with cytotoxic agents. (6704196)
1984
41
The synovium and synovial fluid in multicentric reticulohistiocytosis--a light microscopic, electron microscopic and cytochemical analysis of one case. (6875015)
1983
42
Lipid profile of dermal nodules in multicentric reticulohistiocytosis: 14C and 32P incorporation. (7094402)
1982
43
Ocular and periocular features of multicentric reticulohistiocytosis with paraproteinaemia. A report of two cases. (6942566)
1981
44
The ocular and periocular features of multicentric reticulohistiocytosis with paraproteinaemia. A report of two cases. (6765669)
1981
45
Multicentric reticulohistiocytosis: report of two cases with ultrastructure, tissue culture and immunology studies. (7438524)
1980
46
Multicentric reticulohistiocytosis and malignant disease. (204325)
1978
47
Relationship between multicentric reticulohistiocytosis and tuberculosis. (404438)
1977
48
Atypical multicentric reticulohistiocytosis with paraproteinemia. (931399)
1977
49
Multicentric reticulohistiocytosis: a rare cause of destructive polyarthritis. (1110997)
1975
50
Multicentric reticulohistiocytosis. Fine structural analysis of the synovium and synovial fluid cells. (4370206)
1974

Genetic Variations for Multicentric Reticulohistiocytosis

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Expression for genes affiliated with Multicentric Reticulohistiocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 52R&D Systems
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Pathways related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFSF11
29.5TNFRSF11B, TNFSF11
39.5TNFSF11, TNFRSF11B
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.5TNFSF11, TNFRSF11B
59.2TNF, TNFRSF11B
6
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.1TNF, TNFSF11
79.0TNF, CSF1
8
Hide members
8.7TNF, TNFRSF11B, TNFSF11
9
Hide members
8.7TNF, TNFRSF11B, TNFSF11
10
Hide members
8.7TNF, TNFRSF11B, TNFSF11
118.5CD68, TNF, CSF1
12
Hide members
8.1CSF1, TNFSF11, TNFRSF11B, TNF
138.1TNF, TNFRSF11B, TNFSF11, CSF1

Compounds for genes affiliated with Multicentric Reticulohistiocytosis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1hcc-1449.9TNFRSF11B, TNFSF11
2denosumab44 1110.9TNFRSF11B, TNFSF11
3teriparatide44 1110.9TNFRSF11B, TNFSF11
4polyethylene449.9TNFRSF11B, TNFSF11
5ibandronate44 1110.9TNFSF11, TNFRSF11B
6pamidronate44 49 1111.9TNFRSF11B, TNFSF11
7risedronate44 59 49 28 1113.9TNFSF11, TNFRSF11B
8clodronate44 49 1111.8TNFRSF11B, TNFSF11
9pmma449.8TNFRSF11B, TNFSF11
10geranylgeranyl pyrophosphate449.8TNFSF11, TNFRSF11B
11titanium449.8TNFRSF11B, TNFSF11
12zoledronic acid449.8TNFSF11, TNFRSF11B
13deoxypyridinoline449.7TNFSF11, TNFRSF11B
14tartrate449.7TNFSF11, CSF1
15alendronate44 49 1111.7TNFRSF11B, TNFSF11
16anakinra44 1110.6TNFRSF11B, TNF
17lenalidomide44 1110.5TNFSF11, TNF
18mip 1alpha449.5TNFSF11, TNF
1925-hydroxyvitamin d449.4TNFSF11, TNFRSF11B
20leflunomide49 44 1111.4TNF, TNFSF11
21vitamin k2449.3TNFRSF11B, TNFSF11, CSF1
22celecoxib44 59 28 49 11 2414.3CSF1, TNFSF11, TNFRSF11B
23gp 130449.3TNFSF11, TNFRSF11B, CSF1
241,25 dihydroxy vitamin d3449.3CSF1, TNFSF11, TNFRSF11B
25gm-csf44 2810.2TNF, CSF1
263-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.2TNFSF11, TNFRSF11B
27budesonide44 49 1111.2CSF1, TNF
28ascorbic acid44 2410.2TNFRSF11B, TNFSF11, CSF1
29sulfasalazine44 28 49 1112.1CSF1, TNF
30polymyxin b449.1TNFRSF11B, TNFSF11, TNF
31infliximab44 49 1111.1TNFRSF11B, TNFSF11, TNF
32fluticasone propionate44 49 59 1112.1TNF, CSF1
33polyinosinic-polycytidylic acid449.0CSF1, TNF
34methotrexate44 49 1111.0TNFSF11, TNFRSF11B, TNF
35prednisolone44 28 1111.0CSF1, TNFRSF11B, TNF
36tgf beta1449.0CSF1, TNF, TNFRSF11B
37sb 20358044 599.9TNFSF11, TNFRSF11B, TNF
38n acetylcysteine448.8TNF, TNFSF11, CSF1
39pd 98,059448.5TNFSF11, CSF1, TNF
40ns 39844 599.5TNFSF11, CSF1, TNF, TNFRSF11B
41etanercept44 49 1110.5TNF, TNFSF11, CSF1, TNFRSF11B
42prostaglandin448.5TNFRSF11B, CSF1, TNF, TNFSF11
43calcitriol44 59 11 2411.5CSF1, TNFSF11, TNFRSF11B, TNF
44rantes448.5TNFRSF11B, TNFSF11, TNF, CSF1
45indomethacin44 59 28 1111.5CSF1, TNFSF11, TNFRSF11B, TNF
46ly294002448.5TNFRSF11B, TNF, TNFSF11, CSF1
47genistein44 28 59 2 11 2413.5CSF1, TNF, TNFRSF11B, TNFSF11
48pge2448.5TNFSF11, TNFRSF11B, TNF, CSF1
49dexamethasone44 49 28 1111.4CSF1, TNFRSF11B, TNF, TNFSF11
50vegf448.4TNFSF11, TNFRSF11B, TNF, CSF1

GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

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16Gene Ontology
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Cellular components related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7LYZ, TNF, TNFRSF11B, TNFSF11, CSF1

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:0021589.4TNFSF11, CSF1
2tumor necrosis factor-mediated signaling pathwayGO:0332099.1TNFSF11, TNF
3positive regulation of JNK cascadeGO:0463309.1TNF, TNFSF11
4positive regulation of MAP kinase activityGO:0434068.8TNF, TNFSF11
5positive regulation of osteoclast differentiationGO:0456728.7TNF, TNFSF11, CSF1
6osteoclast differentiationGO:0303168.6TNF, TNFSF11, CSF1
7inflammatory responseGO:0069548.6LYZ, TNF, CSF1

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1TNF, TNFSF11
2cytokine activityGO:0051257.8TNF, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Multicentric Reticulohistiocytosis

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Sources for Multicentric Reticulohistiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet