MCID: MLT016
MIFTS: 46

Multicentric Reticulohistiocytosis malady

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Multicentric Reticulohistiocytosis

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Summaries for Multicentric Reticulohistiocytosis

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NIH Rare Diseases:46 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards based summary: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to xanthomatosis and rheumatoid arthritis, and has symptoms including abnormality of the oral cavity, abnormality of the skin and arthritis. An important gene associated with Multicentric Reticulohistiocytosis is TNFSF11 (Tumor Necrosis Factor Superfamily Member 11), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Osteoclast Signaling. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are immune system and respiratory system.

Disease Ontology:11 A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia:69 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50... more...

Related Diseases for Multicentric Reticulohistiocytosis

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Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1xanthomatosis29.9TNFRSF11B, TNFSF11
2rheumatoid arthritis28.8CSF1, TNFRSF11B, TNFSF11
3arthritis10.4
4osteopetrosis, autosomal recessive 710.4TNFRSF11B, TNFSF11
5hemorrhagic shock and encephalopathy syndrome10.4TNFRSF11B, TNFSF11
6tibial hemimelia10.4TNFRSF11B, TNFSF11
7solar retinopathy10.3TNFRSF11B, TNFSF11
8juvenile retinoschisis10.3TNFRSF11B, TNFSF11
9inflammatory liposarcoma10.3TNFRSF11B, TNFSF11
10pneumatosis cystoides intestinalis10.3TNFRSF11B, TNFSF11
11idiopathic subglottic tracheal stenosis10.3PTPRC, VIM
12bacillary angiomatosis10.3TNFRSF11B, TNFSF11
13acquired hyperkeratosis10.3TNFRSF11B, TNFSF11
14ovarian cystadenocarcinoma10.3PTPRC, VIM
15anaerobic meningitis10.3TNFRSF11B, TNFSF11
16angora hair nevus10.3PTPRC, VIM
17short-rib thoracic dysplasia 1210.3PTPRC, VIM
18bone resorption disease10.3TNFRSF11B, TNFSF11
19anal colloid adenocarcinoma10.3PTPRC, VIM
20dens in dente and palatal invaginations10.2PTPRC, VIM
21physical disorder10.2TNFRSF11B, TNFSF11
22subacute monocytic leukemia10.2TNFRSF11B, TNFSF11
23adenomyoma of uterine corpus10.2TNFRSF11B, VIM
24bone deterioration disease10.2TNFRSF11B, TNFSF11
25transitional meningioma10.2F13A1, VIM
26duodenal obstruction10.2PTPRC, VIM
27anus leiomyosarcoma10.2PTPRC, VIM
28neurotic disorder10.2PTPRC, TNFSF11
29dermatomyositis10.2
30megarbane jalkh syndrome10.2PTPRC, VIM
31pancreatic delta cell neoplasm10.2F13A1, VIM
32hemangioma10.2F13A1, VIM
33malignant adenofibroma10.2F13A1, VIM
34eosinophilic gastroenteritis10.2TNFRSF11B, TNFSF11
35psoriasis susceptibility 110.2TNFRSF11B, TNFSF11
36perivascular epithelioid cell tumor10.2F13A1, VIM
37lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.1F13A1, VIM
38cannabis dependence10.1TNFRSF11B, TNFSF11
39polyclonal hypergammaglobulinemia10.1CSF1, TNFSF11
40palmoplantar keratosis10.0TNFRSF11B, TNFSF11
41chronic rheumatic pericarditis10.0CSF1, TNFSF11
42nail disorder, nonsyndromic congenital, 110.0CSF1, TNFSF11
43neutrophil immunodeficiency syndrome10.0F13A1, VIM
44keloids10.0CSF1, TNFSF11
45leprosy10.0
46granuloma annulare10.0
47lymphoma10.0
48lepromatous leprosy10.0
49melanoma10.0
50chronic rhinitis9.9TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Symptoms for Multicentric Reticulohistiocytosis

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Symptoms:

 52
  • muscle weakness
  • arthritis
  • fever
  • cachexia
  • histiocytosis
  • skin nodule

HPO human phenotypes related to Multicentric Reticulohistiocytosis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 abnormality of the skin hallmark (90%) HP:0000951
3 arthritis hallmark (90%) HP:0001369
4 muscle weakness occasional (7.5%) HP:0001324
5 decreased body weight occasional (7.5%) HP:0004325
6 abnormality of temperature regulation occasional (7.5%) HP:0004370

UMLS symptoms related to Multicentric Reticulohistiocytosis:


umbilical discharge, osler's node, abnormal granulation tissue, skin symptom, vestibulitis

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

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Drugs for Multicentric Reticulohistiocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisonePhase 3131853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
2
VinblastinePhase 3398865-21-413342, 241903
Synonyms:
(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
(2alpha,2'BETA,3beta,4alpha,5beta)-vincaleukoblastine
(2xi,3beta,4'beta,19xi)-vincaleukoblastine
(3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate
143-67-9
1z2b
29060-LE
865-21-4
AC-20335
AC1L21JC
AC1L68D2
AC1MXZJ2
BIDD:PXR0201
BRD-K01188359-065-02-5
BSPBio_001228
BSPBio_003594
Bio-0111
C07201
C46H58N4O9
CCRIS 9002
CHEBI:171516
CHEBI:27375
CHEMBL159
CHEMBL607706
CID13342
CID241903
CID3823887
CID6710780
D08675
DB00570
EINECS 212-734-0
HMS2090K05
HSDB 3263
KBio3_003033
LS-1859
LS-187263
 
MolPort-002-518-262
MolPort-005-910-359
NCGC00022585-04
NCGC00181127-01
NCI-C04842
NCI60_004200
NChemBio.2007.10-comp22
NDC 0002-1452-01
NSC 47842
Neuro_000020
Nincaluicolflastine
Rozevin
SPBio_000680
STOCK1N-38480
Spectrum2_000890
Spectrum3_001994
UNII-5V9KLZ54CY
VLB
VR-8
Velban
Velbe
Vinblastin
Vinblastina
Vinblastina (TN)
Vinblastina [DCIT]
Vinblastina [Dcit]
Vinblastine
Vinblastine (INN)
Vinblastine Sulfate
Vinblastine [INN:BAN]
Vinblastinum
Vinblastinum [INN-Latin]
Vincaleucoblastin
Vincaleucoblastine
Vincaleukoblastine
Vincoblastine
nchembio873-comp22
vinblastine
3
MethotrexatePhase 314961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
4
leucovorinPhase 3104758-05-9143, 54575
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
5glucocorticoidsPhase 34756
6
Folic AcidNutraceuticalPhase 3414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7FolateNutraceuticalPhase 34143

Interventional clinical trials:

idNameStatusNCT IDPhase
1H-9926-LCH III: Treatment Protocol of the Third International Study for Langerhans Cell HistiocytosisCompletedNCT00488605Phase 3
2Prospective Evaluation of Adult Pulmonary Langerhans Cell HistiocytosisCompletedNCT01225601
3International Rare Histiocytic Disorders Registry (IRHDR)RecruitingNCT02285582

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

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Anatomical Context for Multicentric Reticulohistiocytosis

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MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

34
Skin, Bone, Liver, Thyroid, Salivary gland, Lung, Bone marrow

Animal Models for Multicentric Reticulohistiocytosis or affiliated genes

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MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CSF1, PTPRC, TNFRSF11B, TNFSF11, VIM
2MP:00053887.9CSF1, F13A1, PTPRC, TNFSF11, VIM
3MP:00053977.4CSF1, F13A1, PTPRC, TNFRSF11B, TNFSF11, VIM
4MP:00107687.2CSF1, F13A1, PTPRC, TNFRSF11B, TNFSF11, VIM

Publications for Multicentric Reticulohistiocytosis

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Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Multicentric reticulohistiocytosis: a critical review. (25900189)
2015
2
Multicentric reticulohistiocytosis. (25092372)
2014
3
A case of multicentric reticulohistiocytosis. (25211404)
2014
4
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. (23219024)
2013
5
Multicentric reticulohistiocytosis. (22945300)
2013
6
Progressive multicentric reticulohistiocytosis. (22449693)
2012
7
Multicentric reticulohistiocytosis. (23130232)
2011
8
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. (22070706)
2011
9
Multicentric reticulohistiocytosis with dermatomyositis-like features: a more common disease presentation than previously thought. (21252485)
2011
10
Aberrant expression of CD10 in ground-glass-like multinucleated giant cells of multicentric reticulohistiocytosis. (21039790)
2010
11
Infiltration of histiocytes and multinucleated giant cells in the myocardium of a patient with multicentric reticulohistiocytosis. (18679136)
2009
12
Multiple pink papules in the setting of arthritis and fever. Multicentric reticulohistiocytosis (MRH). (18936405)
2008
13
Multicentric reticulohistiocytosis: a systemic osteoclastic disease? (18311766)
2008
14
Multicentric reticulohistiocytosis-mimicking dermatomyositis. Case report and review of the literature. (17377390)
2007
15
Multicentric reticulohistiocytosis with positive anticyclic citrullinated antibodies. (17595939)
2007
16
Multicentric reticulohistiocytosis. (17113966)
2006
17
Refractory multicentric reticulohistiocytosis treated by infliximab: two cases. (15789895)
2005
18
Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium. (16310073)
2005
19
Multicentric reticulohistiocytosis and pregnancy. (15842296)
2005
20
Treatment of multicentric reticulohistiocytosis with etanercept. (15313806)
2004
21
Multicentric reticulohistiocytosis treated successfully with an anti-tumor necrosis factor agent: comment on the article by Gorman et al. (12632456)
2003
22
Multicentric reticulohistiocytosis. (17642822)
2003
23
Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints. (12006317)
2002
24
Multicentric reticulohistiocytosis in a 14-year-old girl. (12437557)
2002
25
Cyclosporine as a treatment for multicentric reticulohistiocytosis. (10685836)
2000
26
Multicentric reticulohistiocytosis in a child: radiologic findings and clinical correlation. (9879265)
1998
27
Atypical multicentric reticulohistiocytosis. (20921740)
1998
28
A case of multicentric reticulohistiocytosis, systemic sclerosis and SjAPgren syndrome. (9301147)
1997
29
Severe multicentric reticulohistiocytosis: disease stabilization achieved with methotrexate and hydroxychloroquine. (9375893)
1997
30
Upper airway involvement in multicentric reticulohistiocytosis. (8643284)
1996
31
Multicentric reticulohistiocytosis. (8929779)
1996
32
Multicentric reticulohistiocytosis. A report of 3 cases and review of literature. (8756156)
1996
33
Multicentric reticulohistiocytosis and methotrexate. (7657881)
1995
34
A unique presentation of multicentric reticulohistiocytosis in pregnancy. (8431218)
1993
35
Unusual digital nodules. Multicentric reticulohistiocytosis (MRH). (1599279)
1992
36
Close temporal and anatomic relationship between multicentric reticulohistiocytosis and carcinoma of the breast. (1629839)
1992
37
Multicentric reticulohistiocytosis in a patient with malignant melanoma: a response to cyclophosphamide and a unique cutaneous feature. (2369421)
1990
38
Multicentric reticulohistiocytosis in a child. (2915287)
1989
39
Multicentric reticulohistiocytosis in a black patient. A case report. (3340902)
1988
40
Multicentric reticulohistiocytosis accompanied by oral and temporomandibular joint manifestations. (3025389)
1987
41
A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T-cell marker characteristics. (3491619)
1986
42
A mesothelioma presenting with multicentric reticulohistiocytosis. (3991408)
1985
43
Multicentric reticulohistiocytosis and SjAPgren's syndrome. (4093930)
1985
44
Multicentric reticulohistiocytosis mimicking rheumatoid arthritis. (4085168)
1985
45
Topical nitrogen mustard therapy in multicentric reticulohistiocytosis. (7061747)
1982
46
Relationship between multicentric reticulohistiocytosis and tuberculosis. (404438)
1977
47
Cardiopulmonary complications in multicentric reticulohistiocytosis. Report of a case. (133639)
1976
48
Multicentric reticulohistiocytosis with ovarian carcinoma. (1273092)
1976
49
Multicentric reticulohistiocytosis. Fine structural analysis of the synovium and synovial fluid cells. (4370206)
1974
50
Multicentric reticulohistiocytosis with extensive bone and joint destruction. (4518826)
1973

Variations for Multicentric Reticulohistiocytosis

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Expression for genes affiliated with Multicentric Reticulohistiocytosis

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Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

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GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

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Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00021589.5CSF1, TNFSF11
2positive regulation of osteoclast differentiationGO:00456729.5CSF1, TNFSF11
3osteoclast differentiationGO:00303169.3CSF1, TNFSF11
4ossificationGO:00015039.2CSF1, TNFSF11
5positive regulation of protein kinase activityGO:00458609.0CSF1, PTPRC

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7CSF1, TNFRSF11B, TNFSF11

Sources for Multicentric Reticulohistiocytosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
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31IUPHAR
32KEGG
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39MGI
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47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
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65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet