MCID: MLT016
MIFTS: 46

Multicentric Reticulohistiocytosis malady

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Multicentric Reticulohistiocytosis

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Summaries for Multicentric Reticulohistiocytosis

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NIH Rare Diseases:48 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. The disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. Last updated: 9/28/2012

MalaCards based summary: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to xanthomatosis and rheumatoid arthritis, and has symptoms including abnormality of the oral cavity, abnormality of the skin and arthritis. An important gene associated with Multicentric Reticulohistiocytosis is TNFSF11 (Tumor Necrosis Factor Superfamily Member 11), and among its related pathways are Rheumatoid arthritis and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and immune system.

Disease Ontology:11 A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia:71 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50... more...

Related Diseases for Multicentric Reticulohistiocytosis

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Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1xanthomatosis29.1TNFRSF11B, TNFSF11
2rheumatoid arthritis28.5CSF1, TNFRSF11B, TNFSF11
3transitional meningioma10.3F13A1, VIM
4pancreatic delta cell neoplasm10.3F13A1, VIM
5hemangioma10.3F13A1, VIM
6malignant adenofibroma10.3F13A1, VIM
7perivascular epithelioid cell tumor10.3F13A1, VIM
8idiopathic subglottic tracheal stenosis10.3PTPRC, VIM
9arthritis10.3
10ovarian cystadenocarcinoma10.3PTPRC, VIM
11angora hair nevus10.3PTPRC, VIM
12short-rib thoracic dysplasia 1210.3PTPRC, VIM
13anal colloid adenocarcinoma10.3PTPRC, VIM
14lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.2F13A1, VIM
15dens in dente and palatal invaginations10.2PTPRC, VIM
16duodenal obstruction10.2PTPRC, VIM
17anus leiomyosarcoma10.2PTPRC, VIM
18megarbane jalkh syndrome10.2PTPRC, VIM
19neutrophil immunodeficiency syndrome10.2F13A1, VIM
20polyclonal hypergammaglobulinemia10.1CSF1, TNFSF11
21dermatomyositis10.1
22chronic rheumatic pericarditis10.1CSF1, TNFSF11
23neurotic disorder10.1PTPRC, TNFSF11
24nail disorder, nonsyndromic congenital, 110.0CSF1, TNFSF11
25keloids10.0CSF1, TNFSF11
26adenomyoma of uterine corpus10.0TNFRSF11B, VIM
27osteopetrosis, autosomal recessive 79.9TNFRSF11B, TNFSF11
28hemorrhagic shock and encephalopathy syndrome9.9TNFRSF11B, TNFSF11
29tibial hemimelia9.9TNFRSF11B, TNFSF11
30malignant giant cell tumor9.9CSF1, TNFSF11
31solar retinopathy9.9TNFRSF11B, TNFSF11
32inflammatory liposarcoma9.9TNFRSF11B, TNFSF11
33epidural neoplasm9.9F13A1, PTPRC, VIM
34pneumatosis cystoides intestinalis9.9TNFRSF11B, TNFSF11
35bacillary angiomatosis9.9TNFRSF11B, TNFSF11
36acquired hyperkeratosis9.9TNFRSF11B, TNFSF11
37pancreas adenocarcinoma9.9CSF1, TNFSF11
38anaerobic meningitis9.9TNFRSF11B, TNFSF11
39bone resorption disease9.9TNFRSF11B, TNFSF11
40leprosy9.8
41granuloma annulare9.8
42lymphoma9.8
43lepromatous leprosy9.8
44physical disorder9.8TNFRSF11B, TNFSF11
45subacute monocytic leukemia9.8TNFRSF11B, TNFSF11
46bone deterioration disease9.8TNFRSF11B, TNFSF11
47eosinophilic gastroenteritis9.8TNFRSF11B, TNFSF11
48myelitis9.8CSF1, PTPRC
49psoriasis susceptibility 19.8TNFRSF11B, TNFSF11
50systemic lupus erythematosus9.7

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Symptoms & Phenotypes for Multicentric Reticulohistiocytosis

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Human phenotypes related to Multicentric Reticulohistiocytosis:

 64 54 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the oral cavity64 hallmark (90%) HP:0000163
2 abnormality of the skin64 hallmark (90%) HP:0000951
3 arthritis64 54 hallmark (90%) Very frequent (99-80%) HP:0001369
4 muscle weakness64 54 occasional (7.5%) Occasional (29-5%) HP:0001324
5 decreased body weight64 occasional (7.5%) HP:0004325
6 abnormality of temperature regulation64 occasional (7.5%) HP:0004370
7 fever54 Occasional (29-5%)
8 cachexia54 Occasional (29-5%)
9 histiocytosis54 Very frequent (99-80%)
10 skin nodule54 Very frequent (99-80%)

UMLS symptoms related to Multicentric Reticulohistiocytosis:


umbilical discharge, osler's node, abnormal granulation tissue, skin symptom, vestibulitis

GenomeRNAi Phenotypes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-589.8CSF1, TNFSF11, VIM

MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4CSF1, PTPRC, TNFRSF11B, TNFSF11, VIM
2MP:00053887.9CSF1, F13A1, PTPRC, TNFSF11, VIM
3MP:00053977.9CSF1, F13A1, PTPRC, TNFRSF11B, TNFSF11, VIM
4MP:00107687.8CSF1, F13A1, PTPRC, TNFRSF11B, TNFSF11, VIM

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

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Drugs for Multicentric Reticulohistiocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethotrexateapprovedPhase 315181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
2
Prednisoneapproved, vet_approvedPhase 3135953-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3
leucovorinapprovedPhase 3108958-05-9143, 54575
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
4
VinblastineapprovedPhase 3413865-21-413342, 241903
Synonyms:
(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
(2alpha,2'BETA,3beta,4alpha,5beta)-vincaleukoblastine
(2xi,3beta,4'beta,19xi)-vincaleukoblastine
(3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate
143-67-9
1z2b
29060-LE
865-21-4
AC-20335
AC1L21JC
AC1L68D2
AC1MXZJ2
BIDD:PXR0201
BRD-K01188359-065-02-5
BSPBio_001228
BSPBio_003594
Bio-0111
C07201
C46H58N4O9
CCRIS 9002
CHEBI:171516
CHEBI:27375
CHEMBL159
CHEMBL607706
CID13342
CID241903
CID3823887
CID6710780
D08675
DB00570
EINECS 212-734-0
HMS2090K05
HSDB 3263
KBio3_003033
LS-1859
LS-187263
 
MolPort-002-518-262
MolPort-005-910-359
NCGC00022585-04
NCGC00181127-01
NCI-C04842
NCI60_004200
NChemBio.2007.10-comp22
NDC 0002-1452-01
NSC 47842
Neuro_000020
Nincaluicolflastine
Rozevin
SPBio_000680
STOCK1N-38480
Spectrum2_000890
Spectrum3_001994
UNII-5V9KLZ54CY
VLB
VR-8
Velban
Velbe
Vinblastin
Vinblastina
Vinblastina (TN)
Vinblastina [DCIT]
Vinblastina [Dcit]
Vinblastine
Vinblastine (INN)
Vinblastine Sulfate
Vinblastine [INN:BAN]
Vinblastinum
Vinblastinum [INN-Latin]
Vincaleucoblastin
Vincaleucoblastine
Vincaleukoblastine
Vincoblastine
nchembio873-comp22
vinblastine
5
Folic Acidapproved, nutraceutical, vet_approvedPhase 3427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6Hormone AntagonistsPhase 312778
7glucocorticoidsPhase 34920
8HormonesPhase 313979
9Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 312767
106-MercaptopurinePhase 3199
11Immunosuppressive AgentsPhase 312770
12Nucleic Acid Synthesis InhibitorsPhase 34855
13Folic Acid AntagonistsPhase 32200
14Antimitotic AgentsPhase 35498
15Antimetabolites, AntineoplasticPhase 37171
16AntimetabolitesPhase 311774
17Anti-Inflammatory AgentsPhase 310355
18Antineoplastic Agents, HormonalPhase 35407
19Antineoplastic Agents, PhytogenicPhase 35420
20Dermatologic AgentsPhase 35674
21Antirheumatic AgentsPhase 310627
22Vitamin B ComplexPhase 34229
23Vitamin B9NutraceuticalPhase 34279
24Folinic AcidNutraceuticalPhase 33150
25FolateNutraceuticalPhase 34279

Interventional clinical trials:

idNameStatusNCT IDPhase
1H-9926-LCH III: Treatment Protocol of the Third International Study for Langerhans Cell HistiocytosisCompletedNCT00488605Phase 3
2Prospective Evaluation of Adult Pulmonary Langerhans Cell HistiocytosisCompletedNCT01225601
3International Rare Histiocytic Disorders Registry (IRHDR)RecruitingNCT02285582

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

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Anatomical Context for Multicentric Reticulohistiocytosis

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MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

36
Skin, Bone, Liver, T cells, Cervix, Monocytes, Salivary gland

Publications for Multicentric Reticulohistiocytosis

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Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 239)
idTitleAuthorsYear
1
Multicentric Reticulohistiocytosis: an Unknown Source of Embolic Stroke. (27839900)
2017
2
Multicentric reticulohistiocytosis (MRH): case report with review of literature between 1991 and 2014 with in depth analysis of various treatment regimens and outcomes. (27026876)
2016
3
Nailfold Capillary Patterns in a Patient With Multicentric Reticulohistiocytosis and Raynaud Phenomenon. (27219314)
2016
4
Efficacy of Vinblastine and Prednisone in Multicentric Reticulohistiocytosis With Onset in Infancy. (27199388)
2016
5
Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. (26652057)
2016
6
Multicentric Reticulohistiocytosis: A Unique Case of Chronic Colitis. (27580770)
2016
7
Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. (27175854)
2016
8
Multicentric reticulohistiocytosis: Rheumatology perspective. (27886798)
2016
9
Multicentric Reticulohistiocytosis in a 5-Year-Old Girl. (27492868)
2016
10
Metastatic Inflammatory Breast Cancer Associated With Multicentric Reticulohistiocytosis Successfully Treated With Zoledronic Acid. (27435627)
2016
11
Multicentric reticulohistiocytosis: a critical review. (25900189)
2015
12
Erythema, papules, and arthralgia associated with liver cancer: report of a rare case of multicentric reticulohistiocytosis. (26045857)
2015
13
Organizing pneumonia associated with multicentric reticulohistiocytosis. (26740877)
2015
14
Bilateral Total Hip Arthroplasty in a Rare Case of Multicentric Reticulohistiocytosis. (26640636)
2015
15
Successful Treatment of Multicentric Reticulohistiocytosis with Adalimumab, Prednisolone and Methotrexate. (26072967)
2015
16
18F-FDG PET/CT Findings in Multicentric Reticulohistiocytosis. (26571445)
2015
17
Multicentric Reticulohistiocytosis: A Case Report of an Atypical Presentation in a 2-Year-Old. (25727569)
2015
18
Multicentric reticulohistiocytosis. (25092372)
2014
19
A case of multicentric reticulohistiocytosis. (25211404)
2014
20
Multicentric reticulohistiocytosis: contrasting presentations in 2 Hispanic patients. (24897136)
2014
21
Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options. (24733253)
2014
22
Multicentric reticulohistiocytosis misdiagnosed as rheumatoid arthritis. (25040783)
2014
23
Multicentric reticulohistiocytosis can mimic rheumatoid arthritis. (24692603)
2014
24
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. (23219024)
2013
25
Multicentric reticulohistiocytosis. (22945300)
2013
26
Multicentric reticulohistiocytosis: a rare yet challenging disease. (23417597)
2013
27
Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. (23555066)
2013
28
Hand surgery for Multicentric Reticulohistiocytosis: A new avenue of treatment and review of the literature. (23796955)
2013
29
Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. (23441782)
2013
30
Treatment of facial lesions of multicentric reticulohistiocytosis by carbon dioxide laser. (24163535)
2013
31
Multicentric reticulohistiocytosis with extra-mammillary Paget's disease: a case report. (24168966)
2013
32
Granuloma annulare mimicking multicentric reticulohistiocytosis. (24314776)
2013
33
Treatment of multicentric reticulohistiocytosis with tocilizumab. (23872542)
2013
34
Progressive multicentric reticulohistiocytosis. (22449693)
2012
35
Overexpression of monocyte chemoattractant protein-1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: a case report. (22435444)
2012
36
Multicentric reticulohistiocytosis: a rare case report. (22837570)
2012
37
Multicentric reticulohistiocytosis presenting with the cutaneous features of photosensitivity dermatitis. (21545508)
2012
38
Resident rounds. Part III: Multicentric reticulohistiocytosis presenting as granuloma annulare. (23547330)
2012
39
Leonine facies in the cutaneous form of multicentric reticulohistiocytosis. (22864143)
2012
40
Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. (22351825)
2012
41
Multicentric reticulohistiocytosis masquerading as dermatomyositis: similar and different features. (21950771)
2012
42
Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. (22949898)
2012
43
Multicentric reticulohistiocytosis and fibroblastic rheumatism. (23040366)
2012
44
Multicentric reticulohistiocytosis. (23130232)
2011
45
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. (22070706)
2011
46
Multicentric reticulohistiocytosis with dermatomyositis-like features: a more common disease presentation than previously thought. (21252485)
2011
47
Multicentric reticulohistiocytosis with elevated cytokine serum levels. (21658110)
2011
48
Paraneoplastic multicentric reticulohistiocytosis: a clinicopathologic challenge. (21508571)
2011
49
Malignancy-associated multicentric reticulohistiocytosis. (20012625)
2011
50
Ultraviolet light-induced KAPbner phenomenon contributes to the development of skin eruptions in multicentric reticulohistiocytosis. (21279300)
2011

Variations for Multicentric Reticulohistiocytosis

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Expression for genes affiliated with Multicentric Reticulohistiocytosis

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Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

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GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

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Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ossificationGO:000150310.0CSF1, TNFSF11
2osteoclast differentiationGO:00303169.9CSF1, TNFSF11
3osteoclast proliferationGO:00021589.9CSF1, TNFSF11
4positive regulation of osteoclast differentiationGO:00456729.9CSF1, TNFSF11
5positive regulation of protein kinase activityGO:00458609.3CSF1, PTPRC

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.6CSF1, TNFRSF11B, TNFSF11

Sources for Multicentric Reticulohistiocytosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet