MCID: MLT016
MIFTS: 57

Multicentric Reticulohistiocytosis malady

Rare diseases, Bone diseases, Skin diseases categories

Summaries for Multicentric Reticulohistiocytosis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. the disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). in the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome. last updated: 9/28/2012

MalaCards: Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to arthritis and rheumatoid arthritis, and has symptoms including enanthema/aphtosa/aphta/leukoplakia, wasted (excluding lipodystrophy)/poorly muscled build/cachexy and follicular/erythematous/edematous papules/milium. An important gene associated with Multicentric Reticulohistiocytosis is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds hcc-1 and tartrate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are no phenotypic analysis and limbs/digits/tail.

Wikipedia:66 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years... more...

Aliases & Classifications for Multicentric Reticulohistiocytosis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 27ICD10 via Orphanet, 26ICD10
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Related Diseases for Multicentric Reticulohistiocytosis

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18GeneCards, 19GeneDecks
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Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.1TNFSF11, TNF
2rheumatoid arthritis30.4HAVCR1, TNF, TNFSF11, TNFRSF11B, CSF1, CD68
3melanoma30.2TNF, TNFSF11, TNFRSF11B, CSF1, CD68
4psoriatic arthritis30.1TNF, TNFSF11, TNFRSF11B
5ankylosing spondylitis30.1TNF, TNFSF11, TNFRSF11B
6arthropathy30.1TNF, TNFSF11, TNFRSF11B
7osteoarthritis30.0TNF, TNFSF11, TNFRSF11B, CSF1, CD68
8dermatomyositis10.5
9lepromatous leprosy10.3
10granuloma annulare10.3
11leprosy10.3
12hydrarthrosis10.1
13nasopharyngitis10.1
14primary biliary cirrhosis10.1
15systemic lupus erythematosus10.1
16ganglioneuroma10.1
17gout10.1
18adenocarcinoma10.1
19dermatitis10.1
20lupus erythematosus10.1
21myelofibrosis10.1
22myopathy10.1
23myositis10.1
24neurofibroma10.1
25ovarian cancer10.1
26pericardial effusion10.1
27pulmonary fibrosis10.1
28spondylitis10.1
29thyroiditis10.1
30tuberculosis10.1
31lupus nephritis10.1
32dysphagia10.1
33myotonia10.1
34nephritis10.1
35pigmented villonodular synovitis10.1CSF1
36blau syndrome10.1TNF
37malignant histiocytosis10.1CSF1
38skin disease10.1CD68
39periodontitis10.1TNFRSF11B
40periapical granuloma10.1TNFSF11
41cutaneous fibrous histiocytoma10.1CD68, HAVCR1
42cherubism10.1TNFSF11
43histiocytosis10.1CD68, CSF1
44monocytic leukemia10.0CSF1, TNF
45atopic dermatitis10.0TNF, HAVCR1
46giant cell tumor10.0CSF1, TNFSF11
47hypersensitivity reaction type ii disease10.0CD68, TNF
48paget disease, juvenile10.0TNFSF11, TNFRSF11B
49polyostotic osteolytic dysplasia, hereditary expansile10.0TNFSF11, TNFRSF11B
50osteosclerosis10.0TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to multicentric reticulohistiocytosis

Symptoms for Multicentric Reticulohistiocytosis

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50Orphanet
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Symptoms:

50
  • enanthema/aphtosa/aphta/leukoplakia
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • follicular/erythematous/edematous papules/milium
  • fever/chilling
  • arthritis/synovitis/synovial proliferation
  • muscle weakness/flaccidity

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Multicentric Reticulohistiocytosis

Drug clinical trials:

Search ClinicalTrials for Multicentric Reticulohistiocytosis

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Search CenterWatch for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

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Anatomical Context for Multicentric Reticulohistiocytosis

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34MalaCards
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MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

34
Skin, Bone, Liver, Lung, Thyroid, Salivary gland, Kidney, Heart, Eye, Bone marrow, Breast, Monocytes, T cells, Cervix

Animal Models for Multicentric Reticulohistiocytosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1CD68, CSF1, TNFSF11, TNF
2MP:00053718.0CSF1, TNFRSF11B, TNFSF11, TNF
3MP:00053827.8TNF, TNFSF11, TNFRSF11B, CSF1
4MP:00053907.5TNF, TNFSF11, TNFRSF11B, CSF1, CD68
5MP:00053977.2CD68, CSF1, TNFRSF11B, TNFSF11, TNF, HAVCR1
6MP:00053877.2HAVCR1, TNF, TNFSF11, TNFRSF11B, CSF1, CD68

Publications for Multicentric Reticulohistiocytosis

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53PubMed
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Articles related to Multicentric Reticulohistiocytosis:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. (23219024)
2013
2
Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. (23555066)
2013
3
Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. (22949898)
2012
4
Multicentric reticulohistiocytosis with elevated cytokine serum levels. (21658110)
2011
5
Multicentric reticulohistiocytosis. (23130232)
2011
6
A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. (22070706)
2011
7
Paraneoplastic multicentric reticulohistiocytosis: a clinicopathologic challenge. (21508571)
2011
8
Multicentric reticulohistiocytosis successfully treated with infliximab: an illustrative case and evaluation of cytokine expression supporting anti-tumor necrosis factor therapy. (18936400)
2008
9
Multiple pink papules in the setting of arthritis and fever. Multicentric reticulohistiocytosis (MRH). (18936405)
2008
10
Multicentric reticulohistiocytosis: a systemic osteoclastic disease? (18311766)
2008
11
Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. (18792542)
2008
12
Multicentric reticulohistiocytosis-mimicking dermatomyositis. Case report and review of the literature. (17377390)
2007
13
Multicentric reticulohistiocytosis with positive anticyclic citrullinated antibodies. (17595939)
2007
14
A case of multicentric reticulohistiocytosis with multiple lytic skull lesions. (16045682)
2005
15
Alleviation of polyarticular syndrome in multicentric reticulohistiocytosis with intravenous zoledronate. (16162909)
2005
16
Refractory multicentric reticulohistiocytosis treated by infliximab: two cases. (15789895)
2005
17
Multicentric reticulohistiocytosis with generalized systemic involvement. (15245533)
2004
18
Multicentric reticulohistiocytosis misdiagnosed as lepromatous leprosy. (15267195)
2003
19
Multicentric reticulohistiocytosis treated successfully with an anti-tumor necrosis factor agent: comment on the article by Gorman et al. (12632456)
2003
20
Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints. (12006317)
2002
21
Multicentric reticulohistiocytosis in a 14-year-old girl. (12437557)
2002
22
Multicentric reticulohistiocytosis associated with SjAPgren's syndrome. (10971349)
2000
23
Multicentric reticulohistiocytosis in a child: radiologic findings and clinical correlation. (9879265)
1998
24
Atypical multicentric reticulohistiocytosis. (20921740)
1998
25
A case of multicentric reticulohistiocytosis, systemic sclerosis and SjAPgren syndrome. (9301147)
1997
26
Upper airway involvement in multicentric reticulohistiocytosis. (8643284)
1996
27
Multicentric reticulohistiocytosis. (8929779)
1996
28
Multicentric reticulohistiocytosis. A report of 3 cases and review of literature. (8756156)
1996
29
Unusual immunocytochemical and ultrastructural features of synovial fluid cells in multicentric reticulohistiocytosis. A case report. (8042427)
1994
30
Unusual digital nodules. Multicentric reticulohistiocytosis (MRH). (1599279)
1992
31
Close temporal and anatomic relationship between multicentric reticulohistiocytosis and carcinoma of the breast. (1629839)
1992
32
Methotrexate treatment of multicentric reticulohistiocytosis. (2066959)
1991
33
Multicentric reticulohistiocytosis accompanied by oral and temporomandibular joint manifestations. (3025389)
1987
34
A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T-cell marker characteristics. (3491619)
1986
35
A case of multicentric reticulohistiocytosis with thyroid involvement. (3771858)
1986
36
A mesothelioma presenting with multicentric reticulohistiocytosis. (3991408)
1985
37
Multicentric reticulohistiocytosis and SjAPgren's syndrome. (4093930)
1985
38
Topical nitrogen mustard therapy in multicentric reticulohistiocytosis. (7061747)
1982
39
Collagen phagocytosis in multicentric reticulohistiocytosis. (7229425)
1981
40
Multicentric reticulohistiocytosis with carcinoma-in-situ of the cervix. (465344)
1979
41
Multicentric reticulohistiocytosis and malignant disease. (204325)
1978
42
Relationship between multicentric reticulohistiocytosis and tuberculosis. (404438)
1977
43
Cardiopulmonary complications in multicentric reticulohistiocytosis. Report of a case. (133639)
1976
44
Multicentric reticulohistiocytosis with ovarian carcinoma. (1273092)
1976
45
Multicentric reticulohistiocytosis (lipoid dermatoarthritis). A multisystem disorder. (5030179)
1972
46
Multicentric reticulohistiocytosis. (5797976)
1969
47
Multicentric reticulohistiocytosis. Report of a case with histochemical studies. (4296608)
1968
48
Myositis and myotonia in a case of multicentric reticulohistiocytosis. (5635595)
1968
49
The nails in multicentric reticulohistiocytosis. (Lipoid dermato-arthritis). (6018996)
1967
50
A STUDY OF MULTICENTRIC RETICULOHISTIOCYTOSIS. (14122094)
1964

Variations for Multicentric Reticulohistiocytosis

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Expression for genes affiliated with Multicentric Reticulohistiocytosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for genes affiliated with Multicentric Reticulohistiocytosis

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 31KEGG, 56Reactome, 5Cell Signaling Technology, 58SinoBiological, 55R&D Systems
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Pathways related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TNFSF11, TNFRSF11B
29.3TNFRSF11B, TNFSF11
3
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.3TNFRSF11B, TNFSF11
49.2CSF1, TNF
59.2TNF, CSF1
69.2CSF1, TNF
79.2CSF1, TNF
8
Show member pathways
Serotonin Transporter Activity39
9.1TNFRSF11B, TNF
9
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.1TNFRSF11B, TNF
10
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.0TNFSF11, TNF
119.0TNF, TNFSF11
129.0TNFSF11, TNF
138.7CD68, CSF1, TNF
148.6CSF1, TNFSF11, TNF
15
Show member pathways
8.6TNF, TNFSF11, CSF1
16
Show member pathways
8.6TNF, TNFSF11, CSF1
178.5TNF, TNFSF11, TNFRSF11B
18
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.5TNFRSF11B, TNFSF11, TNF
19
Show member pathways
8.5TNFRSF11B, TNFSF11, TNF
20
Show member pathways
8.5TNF, TNFSF11, TNFRSF11B
21
Show member pathways
8.1TNF, TNFSF11, TNFRSF11B, CSF1
228.1CSF1, TNFRSF11B, TNFSF11, TNF

Compounds for genes affiliated with Multicentric Reticulohistiocytosis

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1hcc-1469.8TNFRSF11B, TNFSF11
2tartrate469.7TNFSF11, CSF1
3denosumab46 1210.7TNFSF11, TNFRSF11B
4teriparatide46 1210.7TNFRSF11B, TNFSF11
5ibandronate46 1210.7TNFSF11, TNFRSF11B
6polyethylene469.7TNFSF11, TNFRSF11B
7pamidronate46 52 1211.7TNFSF11, TNFRSF11B
8risedronate46 52 30 62 1213.7TNFRSF11B, TNFSF11
9clodronate46 52 1211.7TNFSF11, TNFRSF11B
10pmma469.6TNFRSF11B, TNFSF11
11geranylgeranyl pyrophosphate469.6TNFRSF11B, TNFSF11
12titanium469.6TNFRSF11B, TNFSF11
13zoledronic acid469.6TNFRSF11B, TNFSF11
14deoxypyridinoline469.5TNFRSF11B, TNFSF11
15anakinra46 1210.5TNFRSF11B, TNF
16lenalidomide46 1210.4TNFSF11, TNF
17mip 1alpha469.4TNF, TNFSF11
18alendronate46 52 1211.3TNFSF11, TNFRSF11B
19vitamin k2469.3TNFSF11, TNFRSF11B, CSF1
20celecoxib46 62 30 52 25 1214.3TNFSF11, TNFRSF11B, CSF1
21gp 130469.3CSF1, TNFRSF11B, TNFSF11
221,25 dihydroxy vitamin d3469.3CSF1, TNFRSF11B, TNFSF11
23gm-csf46 3010.3TNF, CSF1
24leflunomide46 52 1211.2TNF, TNFSF11
25ascorbic acid46 2510.2CSF1, TNFRSF11B, TNFSF11
26budesonide46 52 1211.1CSF1, TNF
27prednisolone46 30 1211.1TNF, TNFRSF11B, CSF1
28tgf beta1469.1CSF1, TNFRSF11B, TNF
29doxorubicin46 52 1211.1CSF1, TNFRSF11B, TNFSF11
30polymyxin b469.0TNFRSF11B, TNFSF11, TNF
31infliximab46 52 1210.9TNFRSF11B, TNFSF11, TNF
32sulfasalazine30 46 52 1211.9CSF1, TNF
33n acetylcysteine468.9CSF1, TNFSF11, TNF
34paraffin468.9CD68, CSF1, TNFSF11
35methotrexate52 46 1210.9TNFRSF11B, TNFSF11, TNF
36pd 98,059468.8TNF, TNFSF11, CSF1
37sb 20358046 629.8TNF, TNFSF11, TNFRSF11B
38ns 39846 629.5CSF1, TNFRSF11B, TNFSF11, TNF
39etanercept46 52 1210.5CSF1, TNFRSF11B, TNFSF11, TNF
40prostaglandin468.5CSF1, TNFRSF11B, TNFSF11, TNF
41calcitriol46 62 25 1211.5TNF, TNFSF11, TNFRSF11B, CSF1
42rantes468.5TNF, TNFSF11, TNFRSF11B, CSF1
43indomethacin46 30 62 1211.5TNF, TNFSF11, TNFRSF11B, CSF1
44ly294002468.5TNF, TNFSF11, TNFRSF11B, CSF1
45genistein46 30 62 3 25 1213.5CSF1, TNFRSF11B, TNFSF11, TNF
46pge2468.5CSF1, TNFRSF11B, TNFSF11, TNF
47cycloheximide468.5CSF1, TNFRSF11B, TNFSF11, TNF
48dexamethasone46 52 30 1211.4TNF, TNFSF11, TNFRSF11B, CSF1
49vegf468.4TNF, TNFSF11, TNFRSF11B, CSF1
50lipid468.1CD68, TNFRSF11B, TNFSF11, TNF

GO Terms for genes affiliated with Multicentric Reticulohistiocytosis

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17Gene Ontology
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Cellular components related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CSF1, TNFRSF11B, TNFSF11, TNF

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:0021589.6TNFSF11, CSF1
2ossificationGO:0015039.5CSF1, TNFSF11
3tumor necrosis factor-mediated signaling pathwayGO:0332099.2TNFSF11, TNF
4positive regulation of MAP kinase activityGO:0434069.2TNFSF11, TNF
5positive regulation of JNK cascadeGO:0463309.1TNF, TNFSF11
6positive regulation of protein kinase B signalingGO:0518979.0TNFSF11, TNF
7positive regulation of NF-kappaB transcription factor activityGO:0510929.0TNFSF11, TNF
8organ morphogenesisGO:0098878.9TNF, TNFSF11
9positive regulation of osteoclast differentiationGO:0456728.8CSF1, TNFSF11, TNF
10osteoclast differentiationGO:0303168.8CSF1, TNFSF11, TNF
11positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.7TNFSF11, TNF

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.0TNFSF11, TNF
2cytokine activityGO:0051257.8CSF1, TNFRSF11B, TNFSF11, TNF

Products for genes affiliated with Multicentric Reticulohistiocytosis

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Sources for Multicentric Reticulohistiocytosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet