MCID: MLT084
MIFTS: 37

Multicystic Dysplastic Kidney

Categories: Nephrological diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Multicystic Dysplastic Kidney

MalaCards integrated aliases for Multicystic Dysplastic Kidney:

Name: Multicystic Dysplastic Kidney 56 52 69
Multicystic Kidney Dysplasia 29
Multicystic Renal Dysplasia 56
Mcdk 56

Classifications:



External Ids:

Orphanet 56 ORPHA1851
MESH via Orphanet 43 D021782
UMLS via Orphanet 70 C0345335 C3714581
ICD10 via Orphanet 34 Q61.4

Summaries for Multicystic Dysplastic Kidney

MalaCards based summary : Multicystic Dysplastic Kidney, also known as multicystic kidney dysplasia, is related to unilateral multicystic dysplastic kidney and bilateral multicystic dysplastic kidney. An important gene associated with Multicystic Dysplastic Kidney is PAX2 (Paired Box 2). The drugs Ropivacaine and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include kidney and uterus, and related phenotypes are cardiovascular system and nervous system

Wikipedia : 72 Multicystic dysplastic kidney (MCDK) is a condition that results from the malformation of the kidney... more...

Related Diseases for Multicystic Dysplastic Kidney

Diseases related to Multicystic Dysplastic Kidney via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 unilateral multicystic dysplastic kidney 12.3
2 bilateral multicystic dysplastic kidney 12.3
3 congenital anomalies of kidney and urinary tract 2 11.2
4 renal dysplasia 11.2
5 renal dysplasia, cystic 11.1
6 campomelia, cumming type 11.1
7 congenital anomalies of kidney and urinary tract 11.1
8 renal-hepatic-pancreatic dysplasia 1 11.0
9 ritscher-schinzel syndrome 1 11.0
10 renal-hepatic-pancreatic dysplasia 2 11.0
11 kidney disease 10.2
12 ureterocele 10.0
13 acidophil adenoma 9.9 LGALS3 PAX2
14 pulmonary valve insufficiency 9.9 PAX2 REN
15 pyruvate kinase deficiency 9.8
16 down syndrome 9.8
17 gastroschisis 9.8
18 endocardial fibroelastosis 9.8
19 hemangioma 9.8
20 hydronephrosis 9.8
21 pyelonephritis 9.8
22 choroiditis 9.8
23 oligohydramnios 9.8
24 congenital ichthyosiform erythroderma 9.8
25 vaginitis 9.8
26 cervicitis 9.8
27 dermoid cyst 9.8
28 turner syndrome 9.8
29 lymphocele 9.8
30 collecting duct carcinoma 9.8
31 cavernous hemangioma 9.8
32 cowden disease 9.8
33 autosomal dominant polycystic kidney disease 9.8
34 cleft lip 9.8
35 hydrocele 9.8
36 polycystic kidney disease 9.8
37 aortic coarctation 9.8
38 schinzel giedion syndrome 9.8
39 renal hypodysplasia 9.8
40 vaginal atresia 9.8
41 congenital bilateral megacalycosis 9.8 PAX2 REN
42 inhibited male orgasm 9.7 PAX2 REN
43 hepatic infarction 9.6 AGTR2 REN
44 hyperbiliverdinemia 9.6 PAX2 REN
45 voyeurism 9.6 AGTR2 REN
46 microphthalmia, isolated, with coloboma 7 9.6 AGTR2 REN
47 episodic ataxia 9.5 AGTR2 PAX2
48 hypertension, essential 9.1 AGTR2 REN
49 benign tumor of fallopian tubes 8.6 AGTR2 LGALS3 PAX2 REN

Graphical network of the top 20 diseases related to Multicystic Dysplastic Kidney:



Diseases related to Multicystic Dysplastic Kidney

Symptoms & Phenotypes for Multicystic Dysplastic Kidney

MGI Mouse Phenotypes related to Multicystic Dysplastic Kidney:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.46 AGTR2 LGALS3 PAX2 REN
2 nervous system MP:0003631 9.26 AGTR2 LGALS3 PAX2 REN
3 renal/urinary system MP:0005367 8.92 AGTR2 LGALS3 PAX2 REN

Drugs & Therapeutics for Multicystic Dysplastic Kidney

Drugs for Multicystic Dysplastic Kidney (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved 84057-95-4 71273 175805
2
Ibuprofen Approved 15687-27-1 3672
3 Anesthetics
4 Anesthetics, Local
5 Central Nervous System Depressants
6 Peripheral Nervous System Agents
7 Analgesics
8 Analgesics, Non-Narcotic
9 Anti-Inflammatory Agents
10 Anti-Inflammatory Agents, Non-Steroidal
11 Antirheumatic Agents
12 Cyclooxygenase Inhibitors
13 diuretics
14 Natriuretic Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
2 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
3 The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine Completed NCT00930046
4 Dismembered Pyeloplasty With and Without After Coming Stent Completed NCT02138877
5 Indwelling Double-J Ureteral Stent Versus Externalized Modified-Salle Stent for Pyeloplasty Recruiting NCT02713633
6 Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal Recruiting NCT02140970 Ibuprofen;Placebo
7 Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors Active, not recruiting NCT02276924
8 Ambulatory Blood Pressure Measurement in Children With Congenital Urine Flow Obstruction Available NCT00764543
9 CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome Not yet recruiting NCT02812212

Search NIH Clinical Center for Multicystic Dysplastic Kidney

Genetic Tests for Multicystic Dysplastic Kidney

Genetic tests related to Multicystic Dysplastic Kidney:

id Genetic test Affiliating Genes
1 Multicystic Kidney Dysplasia 29

Anatomical Context for Multicystic Dysplastic Kidney

MalaCards organs/tissues related to Multicystic Dysplastic Kidney:

39
Kidney, Uterus

Publications for Multicystic Dysplastic Kidney

Articles related to Multicystic Dysplastic Kidney:

(show top 50) (show all 75)
id Title Authors Year
1
Large Multicystic Dysplastic Kidney Mimicking a Large Cystic Renal Neoplasm. ( 28658845 )
2017
2
Multicystic dysplastic kidney: Assessment of the need for renal scintigraphy and the safety of conservative treatment. ( 27666954 )
2017
3
Early Nephrectomy in Unilateral Multicystic Dysplastic Kidney in Children Cures Hypertension Early: An Observation. ( 28346956 )
2017
4
Cyst-to-kidney volume ratio in the sonographic diagnosis of unilateral multicystic dysplastic kidney in children. ( 28440349 )
2017
5
Copy number variations in multicystic dysplastic kidney: update for prenatal diagnosis and genetic counseling. ( 26941192 )
2016
6
Prenatal diagnosis of bilateral multicystic dysplastic kidney in three siblings. ( 26966031 )
2016
7
Multicystic dysplastic kidney (MCDK) in the neonate: The role of the urologist. ( 26977201 )
2016
8
Minimally invasive open nephrectomy on children with multicystic dysplastic kidney. ( 28101154 )
2016
9
Re: Multicystic Dysplastic Kidney: Is an Initial Voiding Cystourethrogram Necessary? ( 26853032 )
2016
10
Prenatal diagnosis of fetal multicystic dysplastic kidney via high-resolution whole-genome array. ( 26932690 )
2016
11
Conservative Management of Segmental Multicystic Dysplastic Kidney in Children. ( 26277536 )
2015
12
Uterus didelphys with obstructed hemivagina and contralateral multicystic dysplastic kidney. ( 28509270 )
2015
13
Dermoid Cyst in a Multicystic Dysplastic Kidney: A Case Report and Literature Review. ( 26342317 )
2015
14
Update on Multicystic Dysplastic Kidney. ( 26255066 )
2015
15
Testicular cavernous hemangioma presenting as an ipsilateral lesion in a child with multicystic dysplastic kidney. ( 27735807 )
2015
16
Multicystic dysplastic kidney: a retrospective study. ( 25128997 )
2014
17
Caudal duplication with multicystic dysplastic kidney: a case report. ( 25304120 )
2014
18
The natural history of the multicystic dysplastic kidney - Is limited follow-up warranted? ( 25087179 )
2014
19
Normal non-atretic ureter in multicystic dysplastic kidney: Report of two cases. ( 24604989 )
2014
20
Transcriptional dysregulation in the ureteric bud causes multicystic dysplastic kidney by branching morphogenesis defect. ( 25301096 )
2014
21
Unilateral multicystic dysplastic kidney in children. ( 24827951 )
2014
22
Single center experience in patients with unilateral multicystic dysplastic kidney. ( 24873872 )
2014
23
Multicystic dysplastic kidney: Impact of imaging modality selection on the initial management and prognosis. ( 24731390 )
2014
24
Multicystic dysplastic kidney: is an initial voiding cystourethrogram necessary? ( 25347379 )
2014
25
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney. ( 24481986 )
2014
26
Voiding cystourethrogram in multicystic dysplastic kidney: the pendulum has swung. ( 25347380 )
2014
27
Ultrasound diagnosis of multicystic dysplastic kidney: Is a confirmatory nuclear medicine scan necessary? ( 24909606 )
2014
28
Different phenotypes of HNF1A9 deletion mutants in familial multicystic dysplastic kidneys. ( 23725647 )
2013
29
Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney. ( 23413949 )
2013
30
Segmental multicystic dysplastic kidney in an adult: usefulness of enhanced CT in excretory phase. ( 22782317 )
2013
31
Re: Unilateral multicystic dysplastic kidney: does initial size matter? ( 23663641 )
2013
32
Ultrasound diagnosis of central nervous system anomalies (bifid choroid plexus, ventriculomegaly, Dandy-Walker malformation) associated with multicystic dysplastic kidney disease in a trisomy 9 fetus: case report with literature review. ( 23055272 )
2013
33
Multicystic dysplastic kidney complicated by pyelonephritis. ( 24349603 )
2013
34
Prenatal diagnosis of multicystic dysplastic kidney disease in the second trimester screening. ( 23584791 )
2013
35
Re: Unilateral multicystic dysplastic kidney: does initial size matter? ( 24120811 )
2013
36
Prenatal diagnosis of fetal multicystic dysplastic kidney in the era of three-dimensional ultrasound: 10-year experience. ( 23276564 )
2012
37
Cowden disease and multicystic dysplastic kidney: increased risk of renal cancer? ( 26019827 )
2012
38
Single trocar retroperitoneoscopic nephrectomy for unilateral multicystic dysplastic kidney in children. ( 22290528 )
2012
39
Unilateral multicystic dysplastic kidney: does initial size matter? ( 22410799 )
2012
40
Long-term risk of chronic kidney disease in unilateral multicystic dysplastic kidney. ( 21240528 )
2011
41
Uterus didelphys with unilateral vaginal atresia: multicystic dysplastic kidney is the precursor of "renal agenesis" and the key to early diagnosis of this genital anomaly. ( 21717167 )
2011
42
Unilateral multicystic dysplastic kidney with progressive infundibular stenosis in the contralateral kidney: experience at 1 center and review of literature. ( 21784480 )
2011
43
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( 21291342 )
2011
44
Bilateral congenital midureteric strictures associated with multicystic dysplastic kidney and hydronephrosis: evaluation with MR urography. ( 20714713 )
2011
45
Nephrectomy for multicystic dysplastic kidney and renal hypodysplasia in children: where do we stand? ( 20339852 )
2010
46
A Turner syndrome case associated with anal atresia, interrupted aortic arch and multicystic dysplastic kidney. ( 20560264 )
2010
47
Cross ectopic multicystic dysplastic kidney with ureterocele in nonectopic site. ( 23293688 )
2010
48
Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence, associated urinary tract malformations and the contralateral kidney. ( 19171687 )
2009
49
Unilateral multicystic dysplastic kidney: single-center experience. ( 18696120 )
2009
50
Management and etiology of the unilateral multicystic dysplastic kidney: a review. ( 18481111 )
2009

Variations for Multicystic Dysplastic Kidney

Expression for Multicystic Dysplastic Kidney

Search GEO for disease gene expression data for Multicystic Dysplastic Kidney.

Pathways for Multicystic Dysplastic Kidney

GO Terms for Multicystic Dysplastic Kidney

Biological processes related to Multicystic Dysplastic Kidney according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.37 AGTR2 REN
2 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.32 AGTR2 PAX2
3 mesonephros development GO:0001823 9.26 PAX2 REN
4 renin-angiotensin regulation of aldosterone production GO:0002018 9.16 AGTR2 REN
5 positive regulation of metanephric glomerulus development GO:0072300 8.96 AGTR2 PAX2
6 regulation of metanephros size GO:0035566 8.62 AGTR2 PAX2

Sources for Multicystic Dysplastic Kidney

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....