MMN
MCID: MLT075
MIFTS: 41

Multifocal Motor Neuropathy (MMN) malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 38 50 51 56 69
Multifocal Motor Neuropathy with Conduction Block 50 56
Mmncb 50 56
Mmn 50 56

Characteristics:

Orphanet epidemiological data:

56
multifocal motor neuropathy
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA641
ICD10 via Orphanet 34 G61.8

Summaries for Multifocal Motor Neuropathy

NIH Rare Diseases : 50 multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary : Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to neuropathy and lateral sclerosis. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Pharmaceutical Solutions and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include thyroid, b cells and lung.

NINDS : 51 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia : 71 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to Multifocal Motor Neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Drugs & Therapeutics for Multifocal Motor Neuropathy

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2 Immunoglobulins Phase 3,Phase 2
3 gamma-Globulins Phase 3,Phase 2
4 Immunoglobulins, Intravenous Phase 3,Phase 2
5 Rho(D) Immune Globulin Phase 3,Phase 2
6 Antibodies Phase 3,Phase 2
7
Iron Approved 7439-89-6 23925
8 Antibodies, Anti-Idiotypic

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3
2 Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
3 LIME Study (LFB IVIg MMN Efficacy Study) Completed NCT01951924 Phase 3
4 Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy Completed NCT00268788 Phase 2
5 A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN) Completed NCT00701662 Phase 2
6 Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN) Enrolling by invitation NCT02556437 Phase 2
7 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
8 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678
9 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590
10 sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN Recruiting NCT02271724
11 A Study to Evaluate the Performance of a Diagnostic Test in ALS Recruiting NCT02759913
12 HyQvia in Multifocal Motor Neuropathy Not yet recruiting NCT02885259
13 Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuro Not yet recruiting NCT03008733
14 Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous Immunoglobulin Not yet recruiting NCT02892890

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

39
Thyroid, B Cells, Lung, T Cells, Testes

Publications for Multifocal Motor Neuropathy

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 284)
id Title Authors Year
1
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. ( 27988478 )
2017
2
Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. ( 27400822 )
2016
3
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 27401495 )
2016
4
Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. ( 26991654 )
2016
5
Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. ( 27796190 )
2016
6
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. ( 27134672 )
2016
7
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. ( 27313890 )
2016
8
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. ( 27040062 )
2016
9
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. ( 27655303 )
2016
10
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. ( 27396516 )
2016
11
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. ( 27571543 )
2016
12
Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. ( 27130524 )
2016
13
Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. ( 25695919 )
2015
14
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. ( 25549972 )
2015
15
Complement activity is associated with disease severity in multifocal motor neuropathy. ( 26161430 )
2015
16
Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 25976871 )
2015
17
MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. ( 25736373 )
2015
18
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. ( 25739040 )
2015
19
Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). ( 26329270 )
2015
20
Multifocal Motor Neuropathy Associated with Infliximab. ( 26223843 )
2015
21
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. ( 26280014 )
2015
22
Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). ( 26477025 )
2015
23
Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. ( 25592414 )
2015
24
Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26317434 )
2015
25
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. ( 25468269 )
2015
26
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. ( 26298317 )
2015
27
The pathogenesis of multifocal motor neuropathy and an update on current management options. ( 25941538 )
2015
28
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26218529 )
2015
29
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. ( 25626722 )
2015
30
Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. ( 25620065 )
2015
31
Multifocal motor neuropathy: 30 years from onset to diagnosis. ( 26562827 )
2015
32
Treatment of multifocal motor neuropathy. ( 24395647 )
2014
33
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. ( 25283719 )
2014
34
Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-BarrAc syndrome. ( 25157033 )
2014
35
Immunoglobulin (Ig) in multifocal motor neuropathy (MMN): update on evidence for Ig treatment in MMN. ( 25546756 )
2014
36
Multifocal motor neuropathy with high titers of anti-MAG antibodies. ( 24863375 )
2014
37
Relevance of muscle biopsy for diagnosing multifocal motor neuropathy. ( 24824273 )
2014
38
Multifocal motor neuropathy: lost in conduction block? ( 24487379 )
2014
39
The node of Ranvier in multifocal motor neuropathy. ( 24801202 )
2014
40
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. ( 24741315 )
2014
41
Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. ( 25181830 )
2014
42
Treatment of multifocal motor neuropathy with intravenous immunoglobulin. ( 24699885 )
2014
43
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. ( 25130929 )
2014
44
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. ( 24862982 )
2014
45
Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. ( 24741683 )
2014
46
Multifocal motor neuropathy and muscle hypertrophy. ( 24237645 )
2013
47
MR neurography findings in axonal multifocal motor neuropathy. ( 23893000 )
2013
48
Pharmacokinetics of intravenous immunoglobulin in multifocal motor neuropathy. ( 24336791 )
2013
49
Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. ( 23642723 )
2013
50
Antibodies to GM1: galactocerebroside complexes in multifocal motor neuropathy: it takes two to tango. ( 24006050 )
2013

Variations for Multifocal Motor Neuropathy

Expression for Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for Multifocal Motor Neuropathy

GO Terms for Multifocal Motor Neuropathy

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.46 CD1A CD1E CD40LG FCGR2B
2 regulation of immune response GO:0050776 9.43 CD1A CD40LG FCGR2B
3 negative regulation of interleukin-6 secretion GO:1900165 8.96 BANK1 PTPN22
4 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.62 CD1A CD1E

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 9.26 CD1A CD1E
2 lipopeptide binding GO:0071723 9.16 CD1A CD1E
3 exogenous lipid antigen binding GO:0030884 8.96 CD1A CD1E
4 endogenous lipid antigen binding GO:0030883 8.62 CD1A CD1E

Sources for Multifocal Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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