Multifocal Motor Neuropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NIH Rare Diseases:⁴⁸ Multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to neuropathy and lateral sclerosis. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways are IgA-Producing B Cells in the Intestine and NF-kappaB Signaling. Affiliated tissues include thyroid, b cells and t cells.

NINDS:⁴⁹ Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:⁷¹ Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Sources:
²⁰GeneAnalytics, ²¹GeneCards
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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

id	Related Disease	Score	Top Affiliating Genes
1	neuropathy	10.9
2	lateral sclerosis	10.1
3	glomangiosarcoma	10.1	CD40LG, FCGR2B
4	ovarian serous cystadenocarcinoma	10.1	BLK, CD40LG
5	polyneuropathy	10.1
6	stiff-person syndrome	10.1	CD40LG, PTPN22
7	polyradiculoneuropathy	10.0
8	chronic inflammatory demyelinating polyradiculoneuropathy	10.0
9	demyelinating polyneuropathy	10.0
10	neuronitis	10.0
11	lewis-sumner syndrome	10.0
12	conjunctival vascular disease	10.0	BLK, CD40LG
13	aortic valve prolapse	10.0	CNTN2, FCGR2B
14	chronic inflammatory demyelinating polyneuropathy	10.0
15	motor neuron disease	10.0
16	myoclonus epilepsy	10.0	CD1A, CD1E
17	progressive muscular atrophy	9.9
18	thyroiditis	9.9
19	muscular atrophy	9.9
20	acinic cell breast carcinoma	9.9	BLK, CD40LG
21	chorioretinitis	9.8	BANK1, CD40LG, FCGR2B, PTPN22
22	muscle hypertrophy	9.8
23	lymphoma	9.8
24	respiratory failure	9.8
25	cervicitis	9.8
26	cousin syndrome	9.8	BANK1, CD40LG, FCGR2B, PTPN22
27	rheumatoid arthritis	9.7
28	arthritis	9.7
29	b-cell lymphomas	9.7
30	crohn's disease	9.7
31	restless legs syndrome	9.7
32	mononeuropathy	9.7
33	adenocarcinoma	9.7
34	spondylitis	9.7
35	axonal neuropathy	9.7
36	amyloidosis	9.7
37	susac syndrome	9.7
38	acute motor axonal neuropathy	9.7
39	myelodysplastic myeloproliferative cancer	8.6	BANK1, BLK, CD1A, CD1E, CD40LG, CNTN2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Drugs & Therapeutics for Multifocal Motor Neuropathy

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rho(D) Immune Globulin

Phase 3, Phase 2

326

2

Pharmaceutical Solutions

Phase 3

8192

3

Antibodies

Phase 3, Phase 2

6394

4

Immunoglobulins, Intravenous

Phase 3, Phase 2

333

5

Immunoglobulins

Phase 3, Phase 2

6394

6

gamma-Globulins

Phase 3, Phase 2

326

7

Iron

approved

1165

7439-89-6

23925

Synonyms:

02583_FLUKA

12310_ALDRICH

12310_RIEDEL

129048-51-7

14067-02-8

161135-39-3

190454-13-8

195161-83-2

199281-22-6

209309_ALDRICH

209309_SIAL

255637_ALDRICH

266213_ALDRICH

266256_ALDRICH

267945_ALDRICH

267953_ALDRICH

26Fe

338141_ALDRICH

356808_ALDRICH

356824_ALDRICH

356832_ALDRICH

39344-71-3

3ZhP

413054_ALDRICH

443783-52-6

44890_ALDRICH

44890_FLUKA

675141-17-0

70884-35-4

73135-38-3

7439-89-6

8011-79-8

8053-60-9

AC1L2N38

ATW 230

ATW 432

Ancor B

Ancor en 80/150

Armco iron

Atomel 28

Atomel 300M200

Atomel 500M

Atomel 95

Atomiron 44MR

Atomiron 5M

Atomiron AFP 25

Atomiron AFP 5

C00023

C3518_SIAL

C3518_SIGMA

CCRIS 1580

CHEBI:18248

CID23925

Carbonyl iron

Copy Powder CS 105-175

D007501

DB01592

DSP 1000

DSP 128B

DSP 135

DSP 135C

DSP 138

Diseases (animal), iron overload

Diseases, iron overload

EF 1000

EF 250

EFV 200/300

EFV 250

EFV 250/400

EINECS 231-096-4

Ed-In-Sol

Eisen

Electrolytic iron

F 60 (metal)

FE

FT 3 (element)

Fe

Fe-40

Fe1+

Feronate

Ferretts

Ferro-Caps

Ferro-Time

Ferrousal

Ferrovac E

Ferrum

Ferrum metallicum

GS 6

HF 2 (element)

HL (iron)

HQ (metal)

HS (iron)

HS 4849

HSDB 604

Hemocyte

Hierro

Hoeganaes ATW 230

Hoeganaes EH

IRMM524A_FLUKA

IRMM524B_FLUKA

IRON

Iron (Fe)

Iron (Fe1+)

Iron ion (Fe+)

Iron ion(1+)

Iron monocation

Iron powder

Iron standard for AAS

Iron(1+)

Iron(1+) ion

Iron(III) nitrate solution

Iron, carbonyl

Iron, electrolytic

Iron, elemental

Iron, ion (Fe1+)

Iron, ion (Fe1+) (8CI,9CI)

Iron, reduced

LOHA

LS-3196

MolPort-003-925-001

NC 100

PZh-1M3

PZh-2

PZh1M1

PZh2M

PZh2M1

PZh2M2

PZh3

PZh3M

PZh4M

PZhO

Reduced iron

Remko

SUY-B 2

Siderol

UNII-E1UOL152H7

Vitedyn-Slo

Yieronia

fer

ferrous iron

hierro

8

Antibodies, Anti-Idiotypic

18

Interventional clinical trials:

(show all 14)

id	Name	Status	NCT ID	Phase
1	Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.	Completed	NCT01827072	Phase 3
2	Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy	Completed	NCT00666263	Phase 3
3	LIME Study (LFB IVIg MMN Efficacy Study)	Completed	NCT01951924	Phase 3
4	Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy	Completed	NCT00268788	Phase 2
5	A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)	Completed	NCT00701662	Phase 2
6	Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)	Enrolling by invitation	NCT02556437	Phase 2
7	Change of Nerve Conduction Properties in IVIg Dependent Neuropathies	Unknown status	NCT01655394
8	Effect of Resistance and Aerobic Exercise in CIDP or MMN	Completed	NCT02121678
9	Immunoglobulin Dosage and Administration Form in CIDP and MMN	Completed	NCT02111590
10	sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN	Recruiting	NCT02271724
11	A Study to Evaluate the Performance of a Diagnostic Test in ALS	Recruiting	NCT02759913
12	HyQvia in Multifocal Motor Neuropathy	Not yet recruiting	NCT02885259
13	Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuro	Not yet recruiting	NCT03008733
14	Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous Immunoglobulin	Not yet recruiting	NCT02892890

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

³⁶

Thyroid, B cells, T cells, Testes, Lung

Publications for Multifocal Motor Neuropathy

Sources:
⁵⁷PubMed
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Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 284)

id	Title	Authors	Year
1	Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. (27988478)	Philibert M.... Attarian S.	2017
2	Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. (27400822)	Ishigaki H.... Fukuda T.	2016
3	Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. (27401495)	Markvardsen L.H.... Jakobsen J.	2016
4	Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. (26991654)	Katzberg H.D.... Bril V.	2016
5	Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. (27796190)	Volpe S.	2016
6	Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. (27134672)	Stangel M.... Sommer C.	2016
7	Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. (27313890)	Merola A.... Cocito D.	2016
8	Cervical root sonography to differentiate multifocal motor neuropathy from ALS. (27040062)	Nodera H.... Kaji R.	2016
9	MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. (27655303)	Haakma W.... van der Pol W.L.	2016
10	Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. (27396516)	Ivanovski T.... Miralles F.	2016
11	Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. (27571543)	Jongbloed B.A.... van der Pol W.L.	2016
12	Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. (27130524)	Harschnitz O.... van der Pol W.L.	2016
13	Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. (25695919)	Bromberg M.B.... Franssen H.	2015
14	Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. (25549972)	Vlam L.... Van den Berg L.H.	2015
15	Complement activity is associated with disease severity in multifocal motor neuropathy. (26161430)	Vlam L.... van der Pol W.L.	2015
16	Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. (25976871)	Dyck P.J.... Dyck P.J.	2015
17	MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. (25736373)	Staff N.P.... Howe B.M.	2015
18	Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (25739040)	Umapathi T.... LAcger J.M.	2015
19	Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). (26329270)	Vanhoutte E.K.... Merkies I.S.	2015
20	Multifocal Motor Neuropathy Associated with Infliximab. (26223843)	Rowan C.R.... Cullen G.	2015
21	CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. (26280014)	Furukawa T.... Kaji R.	2015
22	Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). (26477025)	LoewenbrA1ck K.F.... Storch A.	2015
23	Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. (25592414)	FernA!ndez-MenAcndez S.... Saponaro-GonzA!lez A.	2015
24	Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. (26317434)	Doppler K.... Sommer C.	2015
25	Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. (25468269)	Delmont E.... Willison H.	2015
26	Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. (26298317)	Vlam L.... van der Pol W.L.	2015
27	The pathogenesis of multifocal motor neuropathy and an update on current management options. (25941538)	LAcger J.M.... Iancu Ferfoglia R.	2015
28	Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. (26218529)	Doppler K.... Sommer C.	2015
29	Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. (25626722)	Grimm A.... Axer H.	2015
30	Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. (25620065)	Pitarokoili K.... Yoon M.S.	2015
31	Multifocal motor neuropathy: 30 years from onset to diagnosis. (26562827)	Hobson-Webb L.D.... Bey R.D.	2015
32	Treatment of multifocal motor neuropathy. (24395647)	Jinka M.... Chaudhry V.	2014
33	Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)	Notturno F.... Uncini A.	2014
34	Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-BarrAc syndrome. (25157033)	Cats E.A.... Jacobs B.C.	2014
35	Immunoglobulin (Ig) in multifocal motor neuropathy (MMN): update on evidence for Ig treatment in MMN. (25546756)	LAcger J.M.	2014
36	Multifocal motor neuropathy with high titers of anti-MAG antibodies. (24863375)	Bridel C.... Lalive P.H.	2014
37	Relevance of muscle biopsy for diagnosing multifocal motor neuropathy. (24824273)	Finsterer J.... Frank M.	2014
38	Multifocal motor neuropathy: lost in conduction block? (24487379)	Lin C.S.	2014
39	The node of Ranvier in multifocal motor neuropathy. (24801202)	Franssen H.	2014
40	Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)	Lawson V.H.... Arnold W.D.	2014
41	Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. (25181830)	Basta I.... LavrniA8 D.	2014
42	Treatment of multifocal motor neuropathy with intravenous immunoglobulin. (24699885)	Koski C.L.	2014
43	Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)	Furukawa T.... Kaji R.	2014
44	Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)	Kerasnoudis A.... Yoon M.S.	2014
45	Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. (24741683)	Miyashiro A.... Kaji R.	2014
46	Multifocal motor neuropathy and muscle hypertrophy. (24237645)	Geevasinga N.... Ng K.	2013
47	MR neurography findings in axonal multifocal motor neuropathy. (23893000)	Briani C.... Gasparotti R.	2013
48	Pharmacokinetics of intravenous immunoglobulin in multifocal motor neuropathy. (24336791)	Vlam L.... van der Pol W.L.	2013
49	Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. (23642723)	Dimachkie M.M.... Katz J.	2013
50	Antibodies to GM1: galactocerebroside complexes in multifocal motor neuropathy: it takes two to tango. (24006050)	Willison H.J.... Halstead S.K.	2013

Genes related to Multifocal Motor Neuropathy

Sources:
²¹GeneCards
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Genes related to Multifocal Motor Neuropathy:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	GLDN	Gliomedin	28.79	GeneCards inferred via : Publications, Summaries (show sections)
2	CD40LG	CD40 Ligand	28.50	GeneCards inferred via : Disorders, Publications (show sections)
3	BANK1	B-Cell Scaffold Protein With Ankyrin Repeats 1	28.07	GeneCards inferred via : Disorders, Publications (show sections)
4	CNTN2	Contactin 2	28.07	GeneCards inferred via : Disorders, Publications (show sections)
5	FCGR2B	Fc Fragment Of IgG Receptor IIb	28.07	GeneCards inferred via : Disorders, Publications (show sections)
6	PTPN22	Protein Tyrosine Phosphatase, Non-Receptor Type 22	28.07	GeneCards inferred via : Disorders, Publications (show sections)
7	CD1E	CD1e Molecule	28.07	GeneCards inferred via : Disorders, Publications (show sections)
8	CD1A	CD1a Molecule	28.07	GeneCards inferred via : Disorders, Publications (show sections)
9	SMN2	Survival Of Motor Neuron 2, Centromeric	28.07	GeneCards inferred via : Disorders, Publications (show sections)
10	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	28.07	GeneCards inferred via : Disorders, Publications (show sections)

Variations for Multifocal Motor Neuropathy

Expression for genes affiliated with Multifocal Motor Neuropathy

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

Sources:
³Cell Signaling Technology, ⁵⁵PathCards, ⁵⁹R&D Systems, ⁶⁰Reactome
See all MalaCards sources

Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	IgA-Producing B Cells in the Intestine⁵⁹	9.7	CD40LG, FCGR2B
2	NF-kappaB Signaling³	9.2	BLK, CD40LG, PTPN22
3	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell⁶⁰	9.1	CD1A, CD40LG, FCGR2B
4	Class I MHC mediated antigen processing and presentation⁶⁰ Show member pathways Antigen processing- Ubiquitination and Proteasome degradation⁶⁰ Adaptive Immune System⁶⁰	8.1	BLK, CD1A, CD40LG, FCGR2B, PTPN22

GO Terms for genes affiliated with Multifocal Motor Neuropathy

Sources:
¹⁹Gene Ontology
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Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of interleukin-6 secretion	GO:1900165	10.3	BANK1, PTPN22
2	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	10.0	CD1A, CD1E
3	immune response	GO:0006955	9.2	CD1A, CD1E, CD40LG, FCGR2B
4	regulation of immune response	GO:0050776	9.1	CD1A, CD40LG, FCGR2B

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	beta-2-microglobulin binding	GO:0030881	9.7	CD1A, CD1E
2	endogenous lipid antigen binding	GO:0030883	9.6	CD1A, CD1E
3	exogenous lipid antigen binding	GO:0030884	9.6	CD1A, CD1E
4	lipopeptide binding	GO:0071723	9.3	CD1A, CD1E