MCID: MLT075
MIFTS: 51

Multifocal Motor Neuropathy malady

Rare diseases, Neuronal diseases categories

Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:41 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and thyroiditis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are CD40/CD40L signaling and Hematopoietic cell lineage. The compounds monomethyl fumarate and tdac have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and lung, and related mouse phenotypes are renal/urinary system and liver/biliary system.

NINDS:42 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:63 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

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Sources:
30LifeMap Discovery®, 41NIH Rare Diseases, 42NINDS, 47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Multifocal Motor Neuropathy, Aliases & Descriptions:

Name: Multifocal Motor Neuropathy 30 41 42 47 60
Multifocal Motor Neuropathy with Conduction Block 47
 
Mmncb 47
Mmn 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Orphanet47 641
ICD10 via Orphanet26 G61.8

Related Diseases for Multifocal Motor Neuropathy

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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1demyelinating polyneuropathy31.2CNTN2, CD1E
2thyroiditis31.2PTPN22
3arthritis29.8IL10, IL4, IFNG, FCGR2B, PTPN22
4rheumatoid arthritis28.8FCGR2B, IL4, IL2, IFNG, CNTN2, CD40LG
5neuropathy11.4
6multifocal motor neuropathy with conduction block10.9
7lateral sclerosis10.6
8lewis-sumner syndrome10.5
9neuronitis10.5
10polyneuropathy10.5
11blindness10.5
12hemorrhagic fever10.4CD40LG
13periapical granuloma10.4IL4
14motor neuron disease10.4
15chronic inflammatory demyelinating polyradiculoneuropathy10.4
16polyradiculoneuropathy10.4
17lupus erythematosus10.4FCGR2B, CD40LG
18aspergillosis10.3IFNG
19intraocular lymphoma10.3IL10
20muscle hypertrophy10.3
21chronic inflammatory demyelinating polyneuropathy10.3
22respiratory failure10.3
23leprosy10.3IL2
24systemic lupus erythematosus10.3BANK1, BLK
25immunodeficiency, x-linked, with hyper-igm10.2CD40LG, IL4
26b-cell lymphomas10.2
27crohn's disease10.2
28progressive muscular atrophy10.2
29axonal neuropathy10.2
30muscular atrophy10.2
31restless legs syndrome10.2
32adenocarcinoma10.2
33amyloidosis10.2
34cervicitis10.2
35mononeuropathy10.2
36ophthalmoplegia10.2
37spondylitis10.2
38susac syndrome10.2
39secondary amyloidosis10.2
40acute motor axonal neuropathy10.2
41hyper-ige recurrent infection syndrome10.2IFNG, IL4
42cutaneous leishmaniasis10.1IFNG, IL10
43tuberculoid leprosy10.1IFNG, IL10
44t-cell large granular lymphocyte leukemia10.1IL2, CNTN2
45burkitt lymphoma10.1CD40LG, FCGR2B, IL4
46systemic scleroderma10.1PTPN22, CD40LG, IL4
47relapsing-remitting multiple sclerosis10.1IL10, IFNG
48malaria10.0IL10, IFNG
49hashimoto thyroiditis10.0IL4, PTPN22, IFNG
50pregnancy loss, recurrent 110.0IL10, CD40LG

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Multifocal Motor Neuropathy

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

31
B cells, Thyroid, Lung, Testes, T cells

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. (25626722)
2015
2
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)
2014
3
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)
2014
4
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)
2014
5
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)
2014
6
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
7
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
8
A controlled trial of intravenous immunoglobulin in multifocal motor neuropathy. (24725024)
2013
9
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
10
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
11
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
12
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
13
Multifocal motor neuropathy. (22019654)
2011
14
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
15
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
16
Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)
2010
17
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
18
Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)
2009
19
Treatment of multifocal motor neuropathy with immunoglobulin: does route of administration matter? (19405192)
2009
20
Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. (19691531)
2009
21
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
22
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
23
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
24
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
25
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
26
High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)
2006
27
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
28
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
29
Multifocal motor neuropathy: current concepts and controversies. (15770650)
2005
30
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
31
Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)
2003
32
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
33
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
34
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
35
79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)
2001
36
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
37
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)
1999
38
Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)
1999
39
Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)
1999
40
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)
1999
41
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
42
Multifocal motor neuropathy. (9562669)
1998
43
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
44
AAEM case report #30: multifocal motor neuropathy. (8606689)
1996
45
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
46
Multifocal motor neuropathy: electrodiagnostic features. (8114790)
1994
47
Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)
1993
48
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
49
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
50
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)
1988

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, IL4
29.4CD1A, IL4, CD1E
39.4BLK, FCGR2B, BANK1
49.3IFNG, IL10
59.1IFNG, IL2
69.1IL2, IFNG
79.0IL10, FCGR2B, IFNG
89.0IL4, IL10, CD40LG
99.0IFNG, IL10, CD40LG
10
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.8BLK, IL4, IL2
118.6IL2, IL4, IFNG
128.6IL4, IL2, IFNG
13
Show member pathways
Immune response CD16 signaling in NK cells58
8.6IL2, IFNG, IL4
14
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.6IL4, IFNG, IL2
15
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5IFNG, IL10, IL2
16
Show member pathways
IL27-mediated signaling events36
8.5IL2, IFNG, IL10
17
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.5IFNG, IL2, IL10
18
Show member pathways
8.5IL2, IL10, IFNG
19
Show member pathways
8.3IL4, IFNG, FCGR2B, IL2
208.3CD40LG, IFNG, IL2, IL4
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.3IL4, IL2, IFNG, CD40LG
22
Show member pathways
8.2PTPN22, IL4, IL2, IL10
238.0IFNG, IL2, IL4, IL10
24
Show member pathways
8.0IL4, IL2, IL10, IFNG
258.0IFNG, IL4, IL2, IL10
268.0IL10, IL2, IL4, IFNG
27
Show member pathways
Type III interferon signaling36
8.0IL4, IFNG, IL10, IL2
28
Show member pathways
8.0FCGR2B, BLK, IFNG, IL4, IL2
297.8IL2, IL4, PTPN22, BLK, IL10
30
Show member pathways
7.6IFNG, CD40LG, IL10, IL2, IL4
31
Show member pathways
7.6IL10, IL2, IFNG, IL4, CD40LG
32
Show member pathways
7.6IL2, CD40LG, IL10, IFNG, IL4
33
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
7.4IL4, CD40LG, FCGR2B, IFNG, IL10, IL2

Compounds for genes affiliated with Multifocal Motor Neuropathy

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Compounds related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1monomethyl fumarate439.6IL4, IL10
2tdac439.4IL4, IL2
3natalizumab43 1210.4FCGR2B, IFNG, IL10
4daclizumab43 1210.4FCGR2B, CD40LG, IL2
5alemtuzumab43 1210.4FCGR2B, CD40LG, IL2
6adalimumab43 49 1211.4IFNG, IL10, FCGR2B
7tuberculin439.4CD40LG, IFNG, IL10
8praziquantel43 1210.4CD40LG, IL4, IL10
9betaseron439.2IFNG, IL4, IL10
10etanercept43 49 1211.2FCGR2B, IFNG, IL10
11polymyxin b439.1IL4, IL10, IFNG
12rolipram43 59 2811.0IL4, IFNG, IL10
13tarc439.0IL4, IFNG, IL10
14infliximab43 49 1210.9IFNG, IL4, IL10
15allergens438.9IL10, CD40LG, IL4, IFNG
16rituximab43 49 1210.8FCGR2B, IL10, IL2, CD40LG
172,5-oligoadenylate438.7IL2, IL10, IFNG
18ivig438.6FCGR2B, IL4, CD40LG, IFNG, IL10
19herbimycin a43 599.6IFNG, IL4, IL2, CD40LG
20mycophenolate mofetil43 49 1210.6IL10, IL2, IFNG, CD40LG
21thalidomide43 49 59 1211.5CD40LG, IL2, IFNG, IL10
22biotin43 24 1210.5IL4, IL2, IL10, CD40LG
2315-deoxy-delta-12,14-prostaglandin j2438.5IFNG, IL4, IL10
24ifn-alpha438.5IL10, IL2, IFNG
25interferon gamma438.4IL10, IL2, IL4, IFNG
26alpha-galactosylceramide438.4IFNG, IL4, IL2, IL10
27glatiramer acetate43 129.4IL4, IFNG, IL2, IL10
28gm-csf43 289.4IL10, IFNG, IL2, IL4
29con a438.4IL10, IL2, IL4, IFNG
30polyinosinic-polycytidylic acid438.4IL4, IFNG, IL10, IL2
31il 10438.4IFNG, IL4, IL2, IL10
32pentoxifylline43 129.4IL10, IFNG, IL2, IL4
33indomethacin43 28 59 1211.3IL2, IL4, IFNG, CD40LG
34hydrocortisone43 2 59 1211.3IL2, IFNG, IL4, IL10
35tacrolimus43 49 1210.3IL10, IFNG, IL4, IL2
36calcitriol43 59 24 1211.2IL10, IFNG, IL2, IL4
37rapamycin438.2CD40LG, IL2, IFNG, IL10
38il-12438.1IFNG, IL10, IL4, CD40LG, IL2
39okt3438.1IFNG, CD40LG, IL10, IL2, IL4
40ribavirin43 49 1210.1IL2, IL4, IL10, IFNG, CD40LG
41neopterin438.1IL4, IFNG, IL10, CD40LG, IL2
42rantes438.0IL2, IFNG, IL4, CD40LG, IL10
43pge2438.0IL2, IFNG, CD40LG, IL10, IL4
44cycloheximide437.9IL10, IL2, IL4, IFNG, CNTN2
45thymidine43 248.8IL2, IFNG, IL4, IL10, CNTN2, FCGR2B
46histamine43 28 249.8IL10, IL2, IL4, IFNG, FCGR2B, CD40LG
47ionomycin437.8CNTN2, CD40LG, IFNG, IL4, IL2, IL10
48cyclosporin a43 28 599.8IL10, IL2, IL4, IFNG, CD40LG, CNTN2
49vegf437.7CD40LG, CNTN2, IL10, IL2, IL4, IFNG
50dexamethasone43 49 28 1210.5IL4, CD40LG, IFNG, IL10, IL2

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Cellular components related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD40LG, IL4, IFNG
2extracellular spaceGO:00056157.3CD40LG, IL10, IL2, IL4, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:004800710.2CD1E, CD1A
2positive regulation of chemokine biosynthetic processGO:00450809.7IL4, IFNG
3regulation of isotype switchingGO:00451919.6IL4, IL10
4type 2 immune responseGO:00420929.6IL10, IL4
5positive regulation of interleukin-12 productionGO:00327359.6CD40LG, IFNG
6defense response to protozoanGO:00428329.6IFNG, IL4
7regulation of immune responseGO:00507769.6FCGR2B, IL4, CD40LG
8negative regulation of nitric oxide biosynthetic processGO:00450199.6IL10, IL4
9negative regulation of growth of symbiont in hostGO:00441309.5IL10, IFNG
10B cell differentiationGO:00301839.3IL4, IL10, CD40LG
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.2IL4, IL2
12T cell differentiationGO:00302179.2PTPN22, IL2
13B cell proliferationGO:00421009.2CD40LG, IL10
14positive regulation of activated T cell proliferationGO:00421049.2IL2, IL4
15positive regulation of MHC class II biosynthetic processGO:00453489.1IL10, IL4, IFNG
16positive regulation of isotype switching to IgG isotypesGO:00483048.9IL2, IL4, IFNG
17immune responseGO:00069558.6FCGR2B, IL4, IL2, CD1A, CD1E
18negative regulation of apoptotic processGO:00430668.4IL4, IL2, IL10, CD40LG
19positive regulation of transcription from RNA polymerase II promoterGO:00459448.0IL10, IL2, IL4, IFNG

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endogenous lipid antigen bindingGO:003088310.0CD1A, CD1E
2exogenous lipid antigen bindingGO:003088410.0CD1E, CD1A
3lipopeptide bindingGO:00717239.9CD1E, CD1A
4beta-2-microglobulin bindingGO:00308819.7CD1A, CD1E
5growth factor activityGO:00080838.5IL4, IL2, IL10
6cytokine activityGO:00051257.8CD40LG, IL10, IL2, IL4, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

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Sources for Multifocal Motor Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet