Multifocal Motor Neuropathy malady

NIH Rare Diseases:⁴³ Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards: Multifocal Motor Neuropathy is related to thyroiditis and arthritis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are Leishmaniasis and Hematopoietic cell lineage. The compounds pentoxifylline and Antithymocyte globulin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, lung and thyroid, and related mouse phenotypes are renal/urinary system and cellular.

NINDS:⁴⁴ Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:⁶⁴ Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.