MMN
MCID: MLT075
MIFTS: 54

Multifocal Motor Neuropathy (MMN) malady

Rare diseases, Neuronal diseases categories
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Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:42 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and thyroiditis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are CD40/CD40L signaling and Hematopoietic cell lineage. The compounds monomethyl fumarate and tdac have been mentioned in the context of this disorder. Affiliated tissues include thyroid, b cells and lung, and related mouse phenotypes are renal/urinary system and liver/biliary system.

NINDS:43 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:65 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

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Sources:
30LifeMap Discovery¬ģ, 42NIH Rare Diseases, 43NINDS, 48Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Multifocal Motor Neuropathy, Aliases & Descriptions:

Name: Multifocal Motor Neuropathy 30 42 43 48 62
Multifocal Motor Neuropathy with Conduction Block 48
 
Mmncb 48
Mmn 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
multifocal motor neuropathy:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal


External Ids:

ICD10 via Orphanet26 G61.8

Related Diseases for Multifocal Motor Neuropathy

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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1demyelinating polyneuropathy31.3CNTN2, CD1E
2thyroiditis31.2PTPN22
3arthritis29.8IL10, IL4, IFNG, FCGR2B, PTPN22
4rheumatoid arthritis28.8FCGR2B, IL4, IL2, IFNG, CNTN2, CD40LG
5neuropathy11.4
6multifocal motor neuropathy with conduction block10.9
7lewis-sumner syndrome10.5
8amyotrophic lateral sclerosis10.5
9lateral sclerosis10.5
10chronic inflammatory demyelinating polyradiculoneuropathy10.5
11neuronitis10.5
12polyneuropathy10.5
13polyradiculoneuropathy10.5
14blindness10.5
15hemorrhagic fever10.4CD40LG
16periapical granuloma10.4IL4
17motor neuron disease10.4
18lupus erythematosus10.4FCGR2B, CD40LG
19aspergillosis10.3IFNG
20intraocular lymphoma10.3IL10
21chronic inflammatory demyelinating polyneuropathy10.3
22respiratory failure10.3
23leprosy10.3IL2
24systemic lupus erythematosus10.3BANK1, BLK
25immunodeficiency with hyper igm type 110.2CD40LG, IL4
26ankylosing spondylitis10.2
27b-cell lymphomas10.2
28lung adenocarcinoma10.2
29axonal neuropathy10.2
30restless legs syndrome10.2
31adenocarcinoma10.2
32amyloidosis10.2
33cervicitis10.2
34mononeuropathy10.2
35ophthalmoplegia10.2
36spondylitis10.2
37susac syndrome10.2
38acute motor axonal neuropathy10.2
39autosomal dominant hyper ige syndrome10.2IFNG, IL4
40cutaneous leishmaniasis10.2IFNG, IL10
41tuberculoid leprosy10.1IFNG, IL10
42malaria10.1IL10, IFNG
43t-cell large granular lymphocyte leukemia10.1IL2, CNTN2
44burkitt's lymphoma10.1CD40LG, FCGR2B, IL4
45systemic scleroderma10.1PTPN22, CD40LG, IL4
46relapsing-remitting multiple sclerosis10.1IL10, IFNG
47autoimmune thyroiditis10.1IL4, PTPN22, IFNG
48cerebral malaria10.0IL10, IFNG
49bipolar disorder10.0
50multiple mucosal neuroma10.0

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Multifocal Motor Neuropathy

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

32
Thyroid, B cells, Lung, Testes, T cells

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 252)
idTitleAuthorsYear
1
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)
2014
2
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)
2014
3
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)
2014
4
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)
2014
5
Treatment of multifocal motor neuropathy with intravenous immunoglobulin. (24699885)
2014
6
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
7
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
8
A controlled trial of intravenous immunoglobulin in multifocal motor neuropathy. (24725024)
2013
9
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
10
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
11
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
12
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
13
Multifocal motor neuropathy. (22019654)
2011
14
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
15
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
16
Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)
2010
17
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
18
Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)
2009
19
Treatment of multifocal motor neuropathy with immunoglobulin: does route of administration matter? (19405192)
2009
20
Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. (19691531)
2009
21
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
22
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
23
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
24
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
25
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
26
High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)
2006
27
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
28
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
29
Multifocal motor neuropathy: current concepts and controversies. (15770650)
2005
30
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
31
Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)
2003
32
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
33
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
34
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
35
79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)
2001
36
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
37
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)
1999
38
Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)
1999
39
Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)
1999
40
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)
1999
41
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
42
Multifocal motor neuropathy. (9562669)
1998
43
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
44
AAEM case report #30: multifocal motor neuropathy. (8606689)
1996
45
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
46
Multifocal motor neuropathy: electrodiagnostic features. (8114790)
1994
47
Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)
1993
48
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
49
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
50
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)
1988

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Expression patterns in normal tissues for genes affiliated with Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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Pathways related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL4, CD40LG
29.4CD1E, CD1A, IL4
39.4BLK, FCGR2B, BANK1
49.3IL10, IFNG
59.1IL2, IFNG
69.1IL2, IFNG
79.0IL10, IFNG, FCGR2B
89.0CD40LG, IL10, IL4
99.0CD40LG, IL10, IFNG
10
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.8BLK, IL4, IL2
118.6IFNG, IL4, IL2
128.6IFNG, IL4, IL2
13
Show member pathways
Immune response CD16 signaling in NK cells60
8.6IFNG, IL4, IL2
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.6IL2, IL4, IFNG
15
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5IL10, IL2, IFNG
16
Show member pathways
8.5IL10, IL2, IFNG
17
Show member pathways
IL27-mediated signaling events37
8.5IFNG, IL2, IL10
18
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5IL10, IL2, IFNG
19
Show member pathways
8.3FCGR2B, IFNG, IL4, IL2
20
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.3CD40LG, IL2, IL4, IFNG
218.3IFNG, IL4, IL2, CD40LG
22
Show member pathways
8.2IL10, IL2, IL4, PTPN22
23
Show member pathways
Type III interferon signaling37
8.0IFNG, IL4, IL2, IL10
24
Show member pathways
8.0IFNG, IL4, IL2, IL10
258.0IL10, IL2, IL4, IFNG
268.0IL10, IL2, IL4, IFNG
278.0IFNG, IL4, IL2, IL10
28
Show member pathways
8.0BLK, FCGR2B, IFNG, IL4, IL2
297.8BLK, PTPN22, IL4, IL2, IL10
30
Show member pathways
7.6IFNG, IL4, IL2, IL10, CD40LG
31
Show member pathways
7.6IFNG, IL4, IL2, IL10, CD40LG
32
Show member pathways
7.6IFNG, IL4, IL2, IL10, CD40LG
33
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
7.4CD40LG, IL10, IL2, IL4, IFNG, FCGR2B

Compounds for genes affiliated with Multifocal Motor Neuropathy

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Compounds related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1monomethyl fumarate449.6IL4, IL10
2tdac449.4IL4, IL2
3natalizumab44 1110.4FCGR2B, IFNG, IL10
4daclizumab44 1110.4FCGR2B, CD40LG, IL2
5alemtuzumab44 1110.4FCGR2B, CD40LG, IL2
6adalimumab44 50 1111.4IFNG, IL10, FCGR2B
7tuberculin449.4CD40LG, IFNG, IL10
8praziquantel44 1110.4CD40LG, IL4, IL10
9betaseron449.2IFNG, IL4, IL10
10etanercept44 50 1111.2FCGR2B, IFNG, IL10
11polymyxin b449.1IL4, IL10, IFNG
12rolipram44 61 2811.0IL4, IFNG, IL10
13tarc449.0IL4, IFNG, IL10
14infliximab44 50 1110.9IFNG, IL4, IL10
15allergens448.9IL10, CD40LG, IL4, IFNG
16rituximab44 50 1110.8FCGR2B, IL10, IL2, CD40LG
172,5-oligoadenylate448.7IL2, IL10, IFNG
18ivig448.6FCGR2B, IL4, CD40LG, IFNG, IL10
19herbimycin a44 619.6IFNG, IL4, IL2, CD40LG
20mycophenolate mofetil44 50 1110.6IL10, IL2, IFNG, CD40LG
21thalidomide44 50 61 1111.5CD40LG, IL2, IFNG, IL10
22biotin44 24 1110.5IL4, IL2, IL10, CD40LG
2315-deoxy-delta-12,14-prostaglandin j2448.5IFNG, IL4, IL10
24ifn-alpha448.5IL10, IL2, IFNG
25interferon gamma448.4IL10, IL2, IL4, IFNG
26alpha-galactosylceramide448.4IFNG, IL4, IL2, IL10
27glatiramer acetate44 119.4IL4, IFNG, IL2, IL10
28gm-csf44 289.4IL10, IFNG, IL2, IL4
29con a448.4IL10, IL2, IL4, IFNG
30polyinosinic-polycytidylic acid448.4IL4, IFNG, IL10, IL2
31il 10448.4IFNG, IL4, IL2, IL10
32pentoxifylline44 119.4IL10, IFNG, IL2, IL4
33indomethacin44 28 61 1111.3IL2, IL4, IFNG, CD40LG
34hydrocortisone44 2 61 1111.3IL2, IFNG, IL4, IL10
35tacrolimus44 50 1110.3IL10, IFNG, IL4, IL2
36calcitriol44 61 24 1111.2IL10, IFNG, IL2, IL4
37rapamycin448.2CD40LG, IL2, IFNG, IL10
38il-12448.1IFNG, IL10, IL4, CD40LG, IL2
39okt3448.1IFNG, CD40LG, IL10, IL2, IL4
40ribavirin44 50 1110.1IL2, IL4, IL10, IFNG, CD40LG
41neopterin448.1IL4, IFNG, IL10, CD40LG, IL2
42rantes448.0IL2, IFNG, IL4, CD40LG, IL10
43pge2448.0IL2, IFNG, CD40LG, IL10, IL4
44cycloheximide447.9IL10, IL2, IL4, IFNG, CNTN2
45thymidine44 248.8IL2, IFNG, IL4, IL10, CNTN2, FCGR2B
46histamine44 28 249.8IL10, IL2, IL4, IFNG, FCGR2B, CD40LG
47ionomycin447.8CNTN2, CD40LG, IFNG, IL4, IL2, IL10
48cyclosporin a44 28 619.8IL10, IL2, IL4, IFNG, CD40LG, CNTN2
49vegf447.7CD40LG, CNTN2, IL10, IL2, IL4, IFNG
50dexamethasone44 50 28 1110.5IL4, CD40LG, IFNG, IL10, IL2

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Cellular components related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CD40LG, IL4, IFNG
2extracellular spaceGO:0056157.3CD40LG, IL10, IL2, IL4, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:04800710.2CD1E, CD1A
2positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
3regulation of isotype switchingGO:0451919.6IL4, IL10
4type 2 immune responseGO:0420929.6IL10, IL4
5positive regulation of interleukin-12 productionGO:0327359.6CD40LG, IFNG
6defense response to protozoanGO:0428329.6IFNG, IL4
7regulation of immune responseGO:0507769.6FCGR2B, IL4, CD40LG
8negative regulation of nitric oxide biosynthetic processGO:0450199.6IL10, IL4
9negative regulation of growth of symbiont in hostGO:0441309.5IL10, IFNG
10B cell differentiationGO:0301839.3IL4, IL10, CD40LG
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2IL4, IL2
12T cell differentiationGO:0302179.2PTPN22, IL2
13B cell proliferationGO:0421009.2CD40LG, IL10
14positive regulation of activated T cell proliferationGO:0421049.2IL2, IL4
15positive regulation of MHC class II biosynthetic processGO:0453489.1IL10, IL4, IFNG
16positive regulation of isotype switching to IgG isotypesGO:0483048.9IL2, IL4, IFNG
17immune responseGO:0069558.6FCGR2B, IL4, IL2, CD1A, CD1E
18negative regulation of apoptotic processGO:0430668.4IL4, IL2, IL10, CD40LG
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.0IL10, IL2, IL4, IFNG

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exogenous lipid antigen bindingGO:03088410.0CD1A, CD1E
2endogenous lipid antigen bindingGO:03088310.0CD1A, CD1E
3lipopeptide bindingGO:0717239.9CD1E, CD1A
4beta-2-microglobulin bindingGO:0308819.7CD1E, CD1A
5growth factor activityGO:0080838.5IL10, IL2, IL4
6cytokine activityGO:0051257.8CD40LG, IL10, IL2, IL4, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

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Sources for Multifocal Motor Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet