MCID: MLT075
MIFTS: 34

Multifocal Motor Neuropathy malady

Neuronal diseases category

Summaries for Multifocal Motor Neuropathy

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards: Multifocal Motor Neuropathy is related to neuropathy and polyneuropathy. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are Leishmaniasis and Hematopoietic cell lineage. The compounds pentoxifylline and Antithymocyte globulin have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and cellular.

NINDS:43 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:63 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

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42NIH Rare Diseases, 43NINDS, 60UMLS
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Classifications:

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Anatomical: Neuronal diseases


Aliases & Descriptions:

multifocal motor neuropathy 42 43 60


Related Diseases for Multifocal Motor Neuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0SMN2
2polyneuropathy30.6CD40LG
3demyelinating polyneuropathy30.5CNTN2, CD1E
4thyroiditis30.5PTPN22
5arthritis30.1FCGR2B, IFNG, IL10, IL4, PTPN22
6rheumatoid arthritis30.1FCGR2B, IL2, IL4, IL10, CD40LG, PTPN22
7axonal neuropathy10.6
8motor peripheral neuropathy10.5
9peripheral neuropathy10.5
10lateral sclerosis10.4
11neuronitis10.4
12chronic inflammatory demyelinating polyradiculoneuropathy10.4
13amyotrophic lateral sclerosis10.4
14brachial plexus neuropathy10.4
15polyradiculoneuropathy10.4
16chronic polyneuropathy10.4
17motor neuron disease10.4
18multifocal motor neuropathy with conduction block10.4
19diabetic neuropathy10.3
20respiratory failure10.3
21ankylosing spondylitis10.1
22restless legs syndrome10.1
23adenocarcinoma10.1
24amyloidosis10.1
25cervicitis10.1
26gastric adenocarcinoma10.1
27lung adenocarcinoma10.1
28mononeuropathy10.1
29ophthalmoplegia10.1
30spondylitis10.1
31letterer-siwe disease10.0CD1A
32histiocytosis10.0CD1A
33autoimmune hemolytic anemia10.0CD40LG
34guillain-barre syndrome10.0CD40LG
35leptospirosis10.0CD40LG
36rubella10.0CD40LG
37vasculitis10.0CD40LG
38measles10.0CD40LG
39sjogren's syndrome10.0CD40LG
40dengue hemorrhagic fever10.0CD40LG
41adult t-cell leukemia10.0CNTN2
42nephritis10.0CD40LG
43cryoglobulinemic vasculitis10.0CD40LG
44herpes simplex10.0CNTN2
45cryoglobulinemia10.0CD40LG
46hemorrhagic fever10.0CD40LG
47antiphospholipid syndrome10.0CD40LG
48primary immunodeficiency disease10.0CD40LG
49celiac disease10.0PTPN22
50glomerulonephritis10.0CD40LG

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Clinical Features for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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Animal Models for Multifocal Motor Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Multifocal Motor Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.8PTPN22, FCGR2B
2MP:00053848.3FCGR2B, IL10, BLK, BANK1, PTPN22
3MP:00053797.9CD40LG, IL4, IL2, FCGR2B, IFNG
4MP:00053707.3IL10, IL4, IL2, FCGR2B, PTPN22, IFNG
5MP:00053887.2PTPN22, FCGR2B, IL2, IL4, IL10, IFNG
6MP:00053976.4IFNG, PTPN22, FCGR2B, IL2, IL4, BANK1
7MP:00053876.3PTPN22, IFNG, BANK1, BLK, CD40LG, IL10

Publications for Multifocal Motor Neuropathy

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Genetic Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CD40LG
29.4CD1A, CD1E, IL4
39.4FCGR2B, BLK, BANK1
49.3IL2, IL4
5
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9.0IL4, BLK, IL2
68.8CD40LG, IL4, IL10
78.8IL2, IL4, IFNG
8
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8.8IL2, IFNG, IL4
9
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8.5IL2, IL4, IFNG, FCGR2B
10
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8.5IFNG, FCGR2B, IL2, IL4
11
Development PDGF signaling via STATs and NF-kB
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8.5IL10, IFNG, IL2
12
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8.5IL10, IFNG, IL2
13
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8.5IL2, IL10, IFNG
148.5CD40LG, IL4, IL2, IFNG
15
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8.5CD40LG, IL2, IL4, IFNG
16
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8.3CD40LG, IL4, IFNG, IL10
17
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8.2IL2, FCGR2B, IFNG, BLK, IL4
188.0IL10, IFNG, IL4, IL2
198.0IL2, IL4, IL10, IFNG
208.0IL10, IL4, IL2, IFNG
217.8PTPN22, IL2, IL4, IL10, BLK
22
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7.4IL4, FCGR2B, IL2, IL10, CD40LG, IFNG

Compounds for genes affiliated with Multifocal Motor Neuropathy

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.4IL4
2Antithymocyte globulin119.9CD1A, FCGR2B
3glucuronoxylomannan449.7IL10
4vegf449.7IL10, CNTN2
5tdac449.7IL2, IL4
6daclizumab44 1110.6CD40LG, IL2, FCGR2B
7alemtuzumab44 1110.6CD40LG, FCGR2B, IL2
8gm-csf44 2810.6IFNG, IL10
9monomethyl fumarate449.5IL10, IL4
10acidophilus449.2IL4, IL10
11bucillamine449.2IFNG, IL2
12natalizumab44 1110.2IL10, IFNG, FCGR2B
13adalimumab44 49 1111.2IL10, FCGR2B, IFNG
14tuberculin449.2IFNG, CD40LG, IL10
15praziquantel44 1110.2IL10, IL4, CD40LG
16etanercept44 49 1111.1IFNG, FCGR2B, IL10
17betaseron449.0IFNG, IL10, IL4
18polymyxin b448.9IL4, IFNG, IL10
19rantes448.9CD40LG, IFNG, IL4, IL2
20infliximab44 49 1110.8IL4, IL10, IFNG
21rituximab44 49 1110.8IL10, FCGR2B, IL2, CD40LG
22tarc448.8IL4, IFNG, IL10
23herbimycin a44 599.8IL4, CD40LG, IFNG, IL2
242,5-oligoadenylate448.8IL2, IL10, IFNG
2515-deoxy-delta-12,14-prostaglandin j2448.8IFNG, IL4, IL10
26ifn-alpha448.7IL2, IFNG, IL10
27allergens448.7IL10, CD40LG, IFNG, IL4
28mycophenolate mofetil44 49 1110.6IL2, IL10, IFNG, CD40LG
29thalidomide44 49 59 1111.6IFNG, IL2, CD40LG, IL10
30biotin44 11 2410.5IL2, IL4, CD40LG, IL10
31chloroquine44 2 49 28 1112.5IL2, IL4, IL10
32ivig448.4FCGR2B, IL10, IL4, IFNG, CD40LG
33interferon gamma448.4IL4, IL10, IFNG, IL2
34alpha-galactosylceramide448.4IL10, IL4, IL2, IFNG
35glatiramer acetate44 119.4IFNG, IL4, IL10, IL2
36con a448.4IL2, IL4, IL10, IFNG
37polyinosinic-polycytidylic acid448.4IL2, IFNG, IL10, IL4
38il 10448.4IFNG, IL2, IL4, IL10
39tacrolimus44 49 1110.3IL2, IL10, IFNG, IL4
40calcitriol44 59 11 2411.2IL2, IL4, IL10, IFNG
41il-12448.1IL2, IL4, CD40LG, IFNG, IL10
42okt3448.1CD40LG, IFNG, IL10, IL4, IL2
43ribavirin44 49 1110.1IFNG, IL4, IL10, CD40LG, IL2
44neopterin448.1IL10, IL2, IL4, CD40LG, IFNG
45pge2448.0IL10, IL2, IL4, IFNG, CD40LG
46histamine44 28 249.8FCGR2B, IL4, IL10, CD40LG, IFNG, IL2
47ionomycin447.8CD40LG, IL4, IL10, CNTN2, IFNG, IL2
48thymidine44 248.8IL10, FCGR2B, IL2, IFNG, CNTN2, IL4
49cyclosporin a44 28 599.8IFNG, IL2, IL10, CD40LG, CNTN2, IL4
50dexamethasone44 49 28 1110.4IL2, IL4, CD40LG, IFNG, IL10

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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16Gene Ontology
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Cellular components related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7IL2, IL4, IL10, CD40LG, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:04800710.2CD1E, CD1A
2positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, IL4
3positive regulation of interleukin-12 productionGO:0327359.6CD40LG, IFNG
4regulation of immune responseGO:0507769.6FCGR2B, IL4, CD40LG
5defense response to protozoanGO:0428329.5IFNG, IL4
6B cell proliferationGO:0421009.5CD40LG, IL10
7regulation of isotype switchingGO:0451919.4IL4, IL10
8type 2 immune responseGO:0420929.4IL4, IL10
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3IL4, IL2
10negative regulation of nitric oxide biosynthetic processGO:0450199.3IL4, IL10
11negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG
12positive regulation of activated T cell proliferationGO:0421049.2IL2, IL4
13positive regulation of isotype switching to IgG isotypesGO:0483049.1IL2, IL4, IFNG
14B cell differentiationGO:0301839.1CD40LG, IL10, IL4
15positive regulation of MHC class II biosynthetic processGO:0453488.9IL4, IL10, IFNG
16immune responseGO:0069558.8CD1A, CD1E, IL4, IL2, FCGR2B
17negative regulation of apoptotic processGO:0430667.9CD40LG, IL10, IL4, IL2

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exogenous lipid antigen bindingGO:03088410.0CD1A, CD1E
2endogenous lipid antigen bindingGO:03088310.0CD1A, CD1E
3lipopeptide bindingGO:0717239.9CD1E, CD1A
4beta-2-microglobulin bindingGO:0308819.7CD1E, CD1A
5growth factor activityGO:0080838.5IL2, IL4, IL10
6cytokine activityGO:0051257.8IL2, IL4, IL10, CD40LG, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

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Sources for Multifocal Motor Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet