MCID: MLT075
MIFTS: 40

Multifocal Motor Neuropathy malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

About this section

Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 33 46 47 52 66
Multifocal Motor Neuropathy with Conduction Block 46 52
 
Mmncb 46 52
Mmn 46 52

Characteristics:

Orphanet epidemiological data:

52
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet52 ORPHA641
ICD10 via Orphanet29 G61.8

Summaries for Multifocal Motor Neuropathy

About this section
NIH Rare Diseases:46 Multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to neuropathy and fetal erythroblastosis, and has symptoms including pathergy reaction An important gene associated with Multifocal Motor Neuropathy is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic cell lineage and IgA-Producing B Cells in the Intestine. Affiliated tissues include skeletal muscle, testes and thyroid.

NINDS:47 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:69 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

About this section

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy11.0
2fetal erythroblastosis10.3BLK, CD40LG
3gastrointestinal allergy10.3CD1E, CD40LG
4prostatic hypertrophy10.3CD1A, CD40LG
5artemis deficiency10.3CD1E, CD40LG
6macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations10.3CD1A, CD1E
7lateral sclerosis10.2
8polyneuropathy10.2
9polyradiculoneuropathy10.2
10chronic inflammatory demyelinating polyradiculoneuropathy10.2
11demyelinating polyneuropathy10.2
12neuronitis10.2
13lewis-sumner syndrome10.2
14infertility10.1CD40LG, FCGR2B
15chronic inflammatory demyelinating polyneuropathy10.1
16motor neuron disease10.1
17progressive muscular atrophy10.0
18thyroiditis10.0
19muscular atrophy10.0
20angiomyolipoma10.0CD40LG, SMN2
21chronic lymphocytic leukemia10.0CNTN2, FCGR2B
22muscle hypertrophy10.0
23lymphoma10.0
24respiratory failure10.0
25cervicitis10.0
26acute necrotizing encephalitis9.9CNTN2, FCGR2B
27dermatitis herpetiformis, familial9.8CD40LG, PTPN22
28rheumatoid arthritis9.8
29arthritis9.8
30b-cell lymphomas9.8
31crohn's disease9.8
32restless legs syndrome9.8
33mononeuropathy9.8
34adenocarcinoma9.8
35spondylitis9.8
36axonal neuropathy9.8
37amyloidosis9.8
38susac syndrome9.8
39acute motor axonal neuropathy9.8
40blood group incompatibility9.8CD40LG, PTPN22
41xanthomatosis9.7CD40LG, PTPN22
42emphysema, congenital lobar9.6CD40LG, PTPN22
43myelofibrosis9.4CD40LG, PTPN22
44pulmonary subvalvular stenosis9.1BANK1, CD40LG, FCGR2B, PTPN22
45systemic lupus erythematosus8.7BANK1, BLK, CD40LG, FCGR2B, PTPN22
46myasthenia gravis6.9BANK1, BLK, CD1A, CD1E, CD40LG, CNTN2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

About this section

UMLS symptoms related to Multifocal Motor Neuropathy:


pathergy reaction

Drugs & Therapeutics for Multifocal Motor Neuropathy

About this section

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Iron10807439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.CompletedNCT01827072Phase 3
2Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor NeuropathyCompletedNCT00666263Phase 3
3LIME Study (LFB IVIg MMN Efficacy Study)CompletedNCT01951924Phase 3
4Subcutaneous Immunoglobulin Treatment for Multifocal Motor NeuropathyCompletedNCT00268788Phase 2
5A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)CompletedNCT00701662Phase 2
6Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)Not yet recruitingNCT02556437Phase 2
7Effect of Resistance and Aerobic Exercise in CIDP or MMNCompletedNCT02121678
8Immunoglobulin Dosage and Administration Form in CIDP and MMNCompletedNCT02111590
9sCD163 & CD19 as Candidate Biomarkers in CIDP and MMNRecruitingNCT02271724
10A Study to Evaluate the Performance of a Diagnostic Test in ALSRecruitingNCT02759913
11Change of Nerve Conduction Properties in IVIg Dependent NeuropathiesActive, not recruitingNCT01655394
12HyQvia in Multifocal Motor NeuropathyNot yet recruitingNCT02885259
13Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous ImmunoglobulinNot yet recruitingNCT02892890

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

About this section

Anatomical Context for Multifocal Motor Neuropathy

About this section

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

34
Skeletal muscle, Testes, Thyroid, B cells, T cells, Lung

Animal Models for Multifocal Motor Neuropathy or affiliated genes

About this section

Publications for Multifocal Motor Neuropathy

About this section

Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 281)
idTitleAuthorsYear
1
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. (27134672)
2016
2
Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. (25695919)
2015
3
Multifocal motor neuropathy: lost in conduction block? (24487379)
2014
4
Treatment of multifocal motor neuropathy. (24395647)
2014
5
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
6
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
7
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
8
Correlation of Sonographic and Electrophysiological Findings in a Patient with Multifocal Motor Neuropathy. (23253207)
2012
9
Acute-onset multifocal motor neuropathy (AMMN): how we meet the diagnosis. (22463688)
2012
10
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
11
IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy. (20667861)
2011
12
Sleep hypoventilation syndrome and respiratory failure due to multifocal motor neuropathy with conduction block. (21404292)
2011
13
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
14
Acute motor conduction block neuropathy or acute multifocal motor neuropathy: an attempt at a nosological systematization. (20082412)
2010
15
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
16
Interferon beta-1a as adjunctive treatment for multifocal motor neuropathy: an open label trial. (19909484)
2009
17
Oral methotrexate as adjunctive therapy in patients with multifocal motor neuropathy on chronic IVIg therapy. (19909485)
2009
18
Restless legs syndrome in a patient with multifocal motor neuropathy. (19572182)
2009
19
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
20
What's new in multifocal motor neuropathy in 2007-2008? (19192064)
2008
21
Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg and of its predictive criteria in 40 patients. (18079302)
2008
22
Delta32 polymorphism of the chemokine receptor CCR5 in a patient with multifocal motor neuropathy. (17266130)
2007
23
Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system. (16554970)
2006
24
Circulating levels of cytokines and their modulation by intravenous immunoglobulin in multifocal motor neuropathy. (16519784)
2006
25
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
26
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
27
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
28
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
29
Consensus criteria for the diagnosis of multifocal motor neuropathy. (12508306)
2003
30
Efficacy of cyclosporine treatment in multifocal motor neuropathy. (14504978)
2003
31
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
32
Multifocal motor neuropathy: long-term clinical and electrophysiological assessment of intravenous immunoglobulin maintenance treatment. (12135977)
2002
33
Disease severity in multifocal motor neuropathy and its association with the response to immunoglobulin treatment. (11993534)
2002
34
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
35
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)
1999
36
Immunoadsorption in multifocal motor neuropathy. (10546160)
1999
37
Multifocal motor neuropathy and Lewis Sumner syndrome: a clinical spectrum. (10567093)
1999
38
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
39
Multifocal motor neuropathy. (9562669)
1998
40
Amyotrophic lateral sclerosis and multifocal motor neuropathy with conduction block. (9395134)
1997
41
Multifocal motor neuropathy. (12521087)
1997
42
Multifocal motor neuropathy with conduction block after Campylobacter jejuni enteritis. (9040761)
1997
43
Relapsing chronic low-dose corticosteroid-responsive multifocal motor neuropathy with conduction block. (9098673)
1997
44
Acute multifocal motor neuropathy with early spontaneous recovery: a distinct syndrome from Guillain-BarrAc syndrome? (8654320)
1996
45
Multifocal motor neuropathy with conduction block: a study of 24 patients. (7608707)
1995
46
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
47
Multifocal motor neuropathy or CIDP? (8239574)
1993
48
Multifocal motor neuropathy: response to human immune globulin. (8498806)
1993
49
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
50
Multifocal motor neuropathy. (1501600)
1992

Variations for Multifocal Motor Neuropathy

About this section

Expression for genes affiliated with Multifocal Motor Neuropathy

About this section
Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

About this section

GO Terms for genes affiliated with Multifocal Motor Neuropathy

About this section

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:004800710.1CD1A, CD1E
2negative regulation of interleukin-6 secretionGO:19001659.9BANK1, PTPN22
3regulation of immune responseGO:00507769.1CD1A, CD40LG, FCGR2B
4immune responseGO:00069559.0CD1A, CD1E, FCGR2B

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopeptide bindingGO:00717239.6CD1A, CD1E
2endogenous lipid antigen bindingGO:00308839.6CD1A, CD1E
3exogenous lipid antigen bindingGO:00308849.5CD1A, CD1E
4beta-2-microglobulin bindingGO:00308819.3CD1A, CD1E

Sources for Multifocal Motor Neuropathy

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet