MCID: MLT075
MIFTS: 41

Multifocal Motor Neuropathy malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

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Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 35 48 49 54 68
Multifocal Motor Neuropathy with Conduction Block 48 54
 
Mmncb 48 54
Mmn 48 54

Characteristics:

Orphanet epidemiological data:

54
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA641
ICD10 via Orphanet31 G61.8

Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:48 Multifocal motor neuropathy (MMN) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). Signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. MMN is thought to be due to an abnormal immune response, but the underlying cause is not clear. Most people treated with intravenous immune globulin (IVIG) have rapid improvement in weakness, but maintenance IVIG is usually required for sustained improvement. Last updated: 3/2/2016

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to neuropathy and fetal erythroblastosis, and has symptoms including pathergy reaction An important gene associated with Multifocal Motor Neuropathy is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic cell lineage and IgA-Producing B Cells in the Intestine. Affiliated tissues include testes, thyroid and b cells.

NINDS:49 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:71 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy10.9
2fetal erythroblastosis10.3BLK, CD40LG
3gastrointestinal allergy10.3CD1E, CD40LG
4prostatic hypertrophy10.3CD1A, CD40LG
5artemis deficiency10.2CD1E, CD40LG
6macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations10.2CD1A, CD1E
7lateral sclerosis10.1
8infertility10.1CD40LG, FCGR2B
9polyneuropathy10.1
10polyradiculoneuropathy10.0
11chronic inflammatory demyelinating polyradiculoneuropathy10.0
12demyelinating polyneuropathy10.0
13neuronitis10.0
14lewis-sumner syndrome10.0
15chronic inflammatory demyelinating polyneuropathy10.0
16motor neuron disease10.0
17angiomyolipoma10.0CD40LG, SMN2
18chronic lymphocytic leukemia10.0CNTN2, FCGR2B
19progressive muscular atrophy9.9
20thyroiditis9.9
21muscular atrophy9.9
22acute necrotizing encephalitis9.9CNTN2, FCGR2B
23muscle hypertrophy9.8
24lymphoma9.8
25respiratory failure9.8
26cervicitis9.8
27dermatitis herpetiformis, familial9.8CD40LG, PTPN22
28blood group incompatibility9.8CD40LG, PTPN22
29xanthomatosis9.7CD40LG, PTPN22
30rheumatoid arthritis9.7
31arthritis9.7
32b-cell lymphomas9.7
33crohn's disease9.7
34restless legs syndrome9.7
35mononeuropathy9.7
36adenocarcinoma9.7
37spondylitis9.7
38axonal neuropathy9.7
39amyloidosis9.7
40susac syndrome9.7
41acute motor axonal neuropathy9.7
42emphysema, congenital lobar9.6CD40LG, PTPN22
43myelofibrosis9.5CD40LG, PTPN22
44pulmonary subvalvular stenosis9.1BANK1, CD40LG, FCGR2B, PTPN22
45systemic lupus erythematosus8.8BANK1, BLK, CD40LG, FCGR2B, PTPN22
46myasthenia gravis7.2BANK1, BLK, CD1A, CD1E, CD40LG, CNTN2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

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UMLS symptoms related to Multifocal Motor Neuropathy:


pathergy reaction

Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3, Phase 2317
2Pharmaceutical SolutionsPhase 37793
3AntibodiesPhase 3, Phase 26045
4Immunoglobulins, IntravenousPhase 3, Phase 2324
5ImmunoglobulinsPhase 3, Phase 26045
6gamma-GlobulinsPhase 3, Phase 2317
7
Ironapproved11237439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
8Antibodies, Anti-Idiotypic18

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.CompletedNCT01827072Phase 3
2Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor NeuropathyCompletedNCT00666263Phase 3
3LIME Study (LFB IVIg MMN Efficacy Study)CompletedNCT01951924Phase 3
4Subcutaneous Immunoglobulin Treatment for Multifocal Motor NeuropathyCompletedNCT00268788Phase 2
5A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)CompletedNCT00701662Phase 2
6Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)Enrolling by invitationNCT02556437Phase 2
7Change of Nerve Conduction Properties in IVIg Dependent NeuropathiesUnknown statusNCT01655394
8Effect of Resistance and Aerobic Exercise in CIDP or MMNCompletedNCT02121678
9Immunoglobulin Dosage and Administration Form in CIDP and MMNCompletedNCT02111590
10sCD163 & CD19 as Candidate Biomarkers in CIDP and MMNRecruitingNCT02271724
11A Study to Evaluate the Performance of a Diagnostic Test in ALSRecruitingNCT02759913
12HyQvia in Multifocal Motor NeuropathyNot yet recruitingNCT02885259
13Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and NeuroNot yet recruitingNCT03008733
14Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous ImmunoglobulinNot yet recruitingNCT02892890

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

36
Testes, Thyroid, B cells, Lung, T cells

Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. (27988478)
2017
2
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. (27134672)
2016
3
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. (27571543)
2016
4
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. (27655303)
2016
5
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. (27040062)
2016
6
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. (27401495)
2016
7
Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. (27796190)
2016
8
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. (27313890)
2016
9
Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. (27130524)
2016
10
Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. (26991654)
2016
11
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. (27396516)
2016
12
Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. (27400822)
2016
13
Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. (25695919)
2015
14
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. (25549972)
2015
15
Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). (26329270)
2015
16
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. (26218529)
2015
17
Multifocal Motor Neuropathy Associated with Infliximab. (26223843)
2015
18
The pathogenesis of multifocal motor neuropathy and an update on current management options. (25941538)
2015
19
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. (25626722)
2015
20
Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. (26317434)
2015
21
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. (25468269)
2015
22
Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. (25976871)
2015
23
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. (26298317)
2015
24
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. (26280014)
2015
25
Complement activity is associated with disease severity in multifocal motor neuropathy. (26161430)
2015
26
Multifocal motor neuropathy: 30 years from onset to diagnosis. (26562827)
2015
27
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (25739040)
2015
28
Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). (26477025)
2015
29
MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. (25736373)
2015
30
Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. (25620065)
2015
31
Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. (25592414)
2015
32
Multifocal motor neuropathy: lost in conduction block? (24487379)
2014
33
Treatment of multifocal motor neuropathy. (24395647)
2014
34
Relevance of muscle biopsy for diagnosing multifocal motor neuropathy. (24824273)
2014
35
The node of Ranvier in multifocal motor neuropathy. (24801202)
2014
36
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)
2014
37
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)
2014
38
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)
2014
39
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)
2014
40
Treatment of multifocal motor neuropathy with intravenous immunoglobulin. (24699885)
2014
41
Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan. (24741683)
2014
42
Immunoglobulin (Ig) in multifocal motor neuropathy (MMN): update on evidence for Ig treatment in MMN. (25546756)
2014
43
Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. (25181830)
2014
44
Multifocal motor neuropathy with high titers of anti-MAG antibodies. (24863375)
2014
45
Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-BarrAc syndrome. (25157033)
2014
46
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
47
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
48
Acute motor neuropathy with pure distal involvement--a case report of multifocal motor neuropathy. (23416060)
2013
49
Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier. (23926278)
2013
50
Multifocal motor neuropathy. (23995271)
2013

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6CD1A, CD1E
29.5CD40LG, FCGR2B
39.1CD1A, CD40LG, FCGR2B
49.0BLK, CD40LG, PTPN22

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:004800710.3CD1A, CD1E
2negative regulation of interleukin-6 secretionGO:19001659.9BANK1, PTPN22
3immune responseGO:00069559.6CD1A, CD1E, FCGR2B
4regulation of immune responseGO:00507769.1CD1A, CD40LG, FCGR2B

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-2-microglobulin bindingGO:00308819.9CD1A, CD1E
2endogenous lipid antigen bindingGO:00308839.9CD1A, CD1E
3exogenous lipid antigen bindingGO:00308849.8CD1A, CD1E
4lipopeptide bindingGO:00717239.6CD1A, CD1E

Sources for Multifocal Motor Neuropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet