MCID: MLT075
MIFTS: 38

Multifocal Motor Neuropathy malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

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Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 32 45 46 51 65
Multifocal Motor Neuropathy with Conduction Block 45 51
 
Mmncb 45 51
Mmn 45 51

Characteristics:

Orphanet epidemiological data:

51
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 641
ICD10 via Orphanet28 G61.8
UMLS65 C0393847

Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:45 Multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to lymphoma and pancreatitis. An important gene associated with Multifocal Motor Neuropathy is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic cell lineage and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skeletal muscle, testes and prostate.

NINDS:46 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:68 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

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Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3, Phase 2206
2Pharmaceutical SolutionsPhase 37004
3AntibodiesPhase 3, Phase 24477
4Immunologic FactorsPhase 3, Phase 218483
5Immunoglobulins, IntravenousPhase 3, Phase 2211
6ImmunoglobulinsPhase 3, Phase 24477
7Gamma-GlobulinsPhase 222
8
Ironapproved10217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.CompletedNCT01827072Phase 3
2Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor NeuropathyCompletedNCT00666263Phase 3
3LIME Study (LFB IVIg MMN Efficacy Study)Active, not recruitingNCT01951924Phase 3
4Subcutaneous Immunoglobulin Treatment for Multifocal Motor NeuropathyCompletedNCT00268788Phase 2
5A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)CompletedNCT00701662Phase 2
6Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)Not yet recruitingNCT02556437Phase 2
7Effect of Resistance and Aerobic Exercise in CIDP or MMNCompletedNCT02121678
8Immunoglobulin Dosage and Administration Form in CIDP and MMNCompletedNCT02111590
9sCD163 & CD19 as Candidate Biomarkers in CIDP and MMNRecruitingNCT02271724
10A Study to Evaluate the Performance of a Diagnostic Test in ALSRecruitingNCT02759913
11Change of Nerve Conduction Properties in IVIg Dependent NeuropathiesActive, not recruitingNCT01655394

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

33
Skeletal muscle, Testes, Prostate, Endothelial, Thyroid, Liver, Colon

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
Bilateral, Multiple, Episodic Retinal Vein Occlusions Associated With Common Variable Immunodeficiency. (26226509)
2015
2
Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. (23436666)
2013
3
Reduction of ventilator-associated pneumonia in the Neuroscience Intensive Care Unit: a multimodality prevention and testing protocol. (24091431)
2013
4
Trained innate immunity and atherosclerosis. (24184939)
2013
5
Nocardiosis in Mediterranean bivalves: first detection of Nocardia crassostreae in a new host Mytilus galloprovincialis and in Ostrea edulis from the Gulf of Naples (Italy). (24140500)
2013
6
MRI-diagnosed nonalcoholic fatty liver disease is correlated to insulin resistance in adolescents. (24119357)
2013
7
Integrating genetic and imaging investigations into the clinical management of congenital hyperinsulinism. (23347463)
2013
8
Cellular immune mechanisms in myocarditis. (23179049)
2012
9
Distribution of granulocyte-monocyte colony-stimulating factor and its receptor I+-subunit in the adult human brain with specific reference to Alzheimer's disease. (22430742)
2012
10
Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGEa88 production by human gingival fibroblasts. (22452847)
2012
11
Microscopic intravenous leiomyomatosis: an incidental finding at myomectomy. (21281013)
2011
12
Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats. (21557963)
2011
13
Vitamin D receptor (VDR) polymorphisms in the cardiac variant of Gaucher disease. (19784695)
2010
14
Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. (20847308)
2010
15
Chronic urticaria is associated with a differential helminth-arthropod-related atopy phenotype. (20883361)
2010
16
Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy. (19951384)
2009
17
Ubiquitin-mediated proteolysis of HuR by heat shock. (19322201)
2009
18
Cardiovascular mortality and duration of androgen deprivation for locally advanced prostate cancer: analysis of RTOG 92-02. (18243498)
2008
19
Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults. (18641720)
2008
20
Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity. (19069959)
2007
21
An unusual case of Erdheim-Chester disease with features of Langerhans cell histiocytosis. (17492445)
2007
22
TNFalpha blockers do not improve the hearing recovery obtained with glucocorticoid therapy in an autoimmune experimental labyrinthitis. (16547758)
2006
23
Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. (17000758)
2006
24
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. (16374077)
2005
25
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. (16020478)
2005
26
Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers. (16136747)
2005
27
Neurotensin, schizophrenia, and antipsychotic drug action. (15006494)
2004
28
The role of enzymatic features of hypoxia in ulcers]. (12712614)
2003
29
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. (12878588)
2003
30
Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. (14680360)
2003
31
Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms. (14571276)
2003
32
Breakthrough trichosporonosis in a bone marrow transplant recipient receiving caspofungin acetate. (12115115)
2002
33
An analysis of lesion size and location in newly diagnosed cytomegalovirus retinitis. (11772590)
2002
34
Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteoblast-line cells. (12037623)
2001
35
Disorders linked to insufficient androgen action in male children. (11392378)
2001
36
The level of CD4 expression limits infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses. (11069993)
2000
37
Pseudouridine in RNA: what, where, how, and why. (10902565)
2000
38
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48. (10566720)
1999
39
The FANCA gene in Japanese Fanconi anemia: reports of eight novel mutations and analysis of sequence variability. (10090479)
1999
40
Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes. (10194767)
1999
41
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. (8893739)
1996
42
Onset of depressive episodes in a woman with seasonal affective disorder of "spring type" coincident with atmospheric temperature, but not with sunshine duration. (8201789)
1993
43
Taurodontism and the identification of a mass disaster victim. (8330663)
1993
44
HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls. (1662403)
1991
45
The COUP-TFs compose a family of functionally related transcription factors. (1820218)
1991
46
Novel method to observe the interface between adhesive resin and dentin by staining Fe3+ with tannic acid]. (1725831)
1990
47
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
48
Studies on cerebral lipidosis. Enzymatic diagnosis of metachromatic leukodystrophy. (4993715)
1970
49
Intermediate coronary syndrome. (13779654)
1961
50

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 secretionGO:19001659.3BANK1, PTPN22

Sources for Multifocal Motor Neuropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet