Multifocal Motor Neuropathy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Multifocal Motor Neuropathy

Sources:
⁴²NIH Rare Diseases, ⁴³NINDS, ⁶⁴Wikipedia, ³²MalaCards
See all sources

NIH Rare Diseases:⁴² Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and thyroiditis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are CD40/CD40L signaling and Hematopoietic cell lineage. The compounds monomethyl fumarate and tdac have been mentioned in the context of this disorder. Affiliated tissues include thyroid, b cells and lung, and related mouse phenotypes are renal/urinary system and liver/biliary system.

NINDS:⁴³ Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:⁶⁴ Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

Sources:
³¹LifeMap Discovery®, ⁴²NIH Rare Diseases, ⁴³NINDS, ⁴⁸Orphanet, ⁶¹UMLS, ²⁷ICD10 via Orphanet
See all sources

Multifocal Motor Neuropathy, Aliases & Descriptions:

Name: Multifocal Motor Neuropathy ³¹ ⁴² ⁴³ ⁴⁸ ⁶¹

Multifocal Motor Neuropathy with Conduction Block ⁴⁸

Mmncb ⁴⁸

Mmn ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases

ICD10: ²⁷

Diseases of the nervous system

Polyneuropathies and other disorders of the peripheral nervous system

Inflammatory polyneuropathy

Other inflammatory polyneuropathies

Orphanet: ⁴⁸

Rare neurological diseases

Characteristics (Orphanet epidemiological data):

⁴⁸

multifocal motor neuropathy:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal

External Ids:

ICD10 via Orphanet²⁷ G61.8

Related Diseases for Multifocal Motor Neuropathy

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 103)

id	Related Disease	Score	Top Affiliating Genes
1	demyelinating polyneuropathy	31.3	CNTN2, CD1E
2	thyroiditis	31.2	PTPN22
3	arthritis	29.8	IL10, IL4, IFNG, FCGR2B, PTPN22
4	rheumatoid arthritis	28.8	FCGR2B, IL4, IL2, IFNG, CNTN2, CD40LG
5	neuropathy	11.4
6	multifocal motor neuropathy with conduction block	10.9
7	lewis-sumner syndrome	10.5
8	amyotrophic lateral sclerosis	10.5
9	lateral sclerosis	10.5
10	chronic inflammatory demyelinating polyradiculoneuropathy	10.5
11	neuronitis	10.5
12	polyneuropathy	10.5
13	polyradiculoneuropathy	10.5
14	blindness	10.5
15	hemorrhagic fever	10.4	CD40LG
16	periapical granuloma	10.4	IL4
17	motor neuron disease	10.4
18	lupus erythematosus	10.4	FCGR2B, CD40LG
19	aspergillosis	10.3	IFNG
20	intraocular lymphoma	10.3	IL10
21	chronic inflammatory demyelinating polyneuropathy	10.3
22	respiratory failure	10.3
23	leprosy	10.3	IL2
24	systemic lupus erythematosus	10.3	BANK1, BLK
25	immunodeficiency with hyper igm type 1	10.2	CD40LG, IL4
26	ankylosing spondylitis	10.2
27	b-cell lymphomas	10.2
28	lung adenocarcinoma	10.2
29	axonal neuropathy	10.2
30	restless legs syndrome	10.2
31	adenocarcinoma	10.2
32	amyloidosis	10.2
33	cervicitis	10.2
34	mononeuropathy	10.2
35	ophthalmoplegia	10.2
36	spondylitis	10.2
37	susac syndrome	10.2
38	acute motor axonal neuropathy	10.2
39	autosomal dominant hyper ige syndrome	10.2	IFNG, IL4
40	cutaneous leishmaniasis	10.2	IFNG, IL10
41	tuberculoid leprosy	10.1	IFNG, IL10
42	malaria	10.1	IL10, IFNG
43	t-cell large granular lymphocyte leukemia	10.1	IL2, CNTN2
44	burkitt's lymphoma	10.1	CD40LG, FCGR2B, IL4
45	systemic scleroderma	10.1	PTPN22, CD40LG, IL4
46	relapsing-remitting multiple sclerosis	10.1	IL10, IFNG
47	autoimmune thyroiditis	10.1	IL4, PTPN22, IFNG
48	cerebral malaria	10.0	IL10, IFNG
49	bipolar disorder	10.0
50	multiple mucosal neuroma	10.0

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:

Symptoms for Multifocal Motor Neuropathy

Drugs & Therapeutics for Multifocal Motor Neuropathy

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Multifocal Motor Neuropathy

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

³²

Thyroid, B cells, Lung, Testes, T cells

Animal Models for Multifocal Motor Neuropathy or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Multifocal Motor Neuropathy:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.4	PTPN22, FCGR2B, IFNG, IL4, CD40LG
2	liver/biliary system phenotype	MP:0005370	7.5	PTPN22, FCGR2B, IFNG, IL4, IL2, IL10
3	respiratory system phenotype	MP:0005388	7.5	PTPN22, FCGR2B, IFNG, IL4, IL2, IL10
4	digestive/alimentary phenotype	MP:0005381	7.4	PTPN22, FCGR2B, IFNG, IL4, IL2, IL10
5	cardiovascular system phenotype	MP:0005385	7.3	PTPN22, FCGR2B, IFNG, IL2, IL10, CD40LG
6	endocrine/exocrine gland phenotype	MP:0005379	7.2	PTPN22, FCGR2B, IFNG, IL4, IL2, IL10
7	cellular phenotype	MP:0005384	7.0	PTPN22, FCGR2B, IFNG, IL4, IL2, IL10
8	homeostasis/metabolism phenotype	MP:0005376	7.0	FCGR2B, IFNG, IL4, IL2, IL10, CD40LG
9	hematopoietic system phenotype	MP:0005397	6.4	CD40LG, BLK, PTPN22, FCGR2B, IFNG, IL4
10	immune system phenotype	MP:0005387	6.4	BLK, PTPN22, FCGR2B, IFNG, IL4, IL2

Publications for Multifocal Motor Neuropathy

Sources:
⁵¹PubMed
See all sources

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 252)

id	Title	Authors	Year
1	Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)	Notturno F.... Uncini A.	2014
2	Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)	Lawson V.H.... Arnold W.D.	2014
3	Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)	Furukawa T.... Kaji R.	2014
4	Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)	Kerasnoudis A.... Yoon M.S.	2014
5	Treatment of multifocal motor neuropathy with intravenous immunoglobulin. (24699885)	Koski C.L.	2014
6	Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)	Vlam L.... van der Pol W.L.	2013
7	Multifocal motor neuropathy: current therapies and novel strategies. (23516024)	Nobile-Orazio E.... Gallia F.	2013
8	A controlled trial of intravenous immunoglobulin in multifocal motor neuropathy. (24725024)	Hahn A.F.... Koski C.L.	2013
9	Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)	Suturkova L.... Basta I.	2013
10	Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)	Sousa A.P.... Medeiros L.	2013
11	A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)	Rigamonti A.... Agostoni E.	2012
12	Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)	Akaza M.... Yokota T.	2011
13	Multifocal motor neuropathy. (22019654)	Nguyen T.P.... Chaudhry V.	2011
14	Activity-dependent conduction block in multifocal motor neuropathy. (21171095)	Straver D.C.... Franssen H.	2011
15	Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)	van der Pol W.L.... van den Berg L.H.	2010
16	Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)	BoArio D.... Lefaucheur J.P.	2010
17	Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)	Stieglbauer K.... Aichner F.T.	2009
18	Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)	Harbo T.... Jakobsen J.	2009
19	Treatment of multifocal motor neuropathy with immunoglobulin: does route of administration matter? (19405192)	Dimberg E.L.	2009
20	Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. (19691531)	Eftimov F.... van Schaik I.N.	2009
21	New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)	Cats E.A.... van den Berg L.H.	2008
22	No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)	Axelson H.W.... Askmark H.	2008
23	Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)	Leger J.M.... Lievens I.	2007
24	Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)	Lange D.J.... Rowland L.P.	2006
25	Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)	Delmont E.... Pouget J.	2006
26	High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)	Brannagan T.H.... Gladstone D.E.	2006
27	Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)	Umapathi T.... LAcger J.M.	2005
28	Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)	Beekman R.... Wokke J.H.	2005
29	Multifocal motor neuropathy: current concepts and controversies. (15770650)	Nobile-Orazio E.... Priori A.	2005
30	Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)	Reisin R.C.... Jadzinsky M.	2005
31	Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)	Kaji R.	2003
32	Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)	Veltkamp R.... Meinck H.M.	2003
33	Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)	Noguchi M.... Oshimi K.	2003
34	Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)	Toscano A.... Messina C.	2002
35	79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)	Hughes P.R.	2001
36	Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)	van den Berg-Vos R.M.... Wokke J.H.	2000
37	Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)	Lewis R.A.	1999
38	Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)	Finsterer J.... Mamoli B.	1999
39	Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)	Bentes C.... Sales-LuA-s M.L.	1999
40	Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)	Parry G.J.	1999
41	Electrophysiologic findings in multifocal motor neuropathy. (9633785)	RAPsler K.M.	1998
42	Multifocal motor neuropathy. (9562669)	Chaudhry V.	1998
43	Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)	Meucci N.... Nobile-Orazio E.	1997
44	AAEM case report #30: multifocal motor neuropathy. (8606689)	Parry G.J.	1996
45	T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)	Heidenreich F.... Jovin T.	1994
46	Multifocal motor neuropathy: electrodiagnostic features. (8114790)	Chaudhry V.... Griffin J.W.	1994
47	Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)	Yuki N.... Tsuji S.	1993
48	Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)	Charles N.... Bady B.	1992
49	Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)	Sumner A.J.	1991
50	A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)	Pestronk A.... Adams R.N.	1988

Genes related to Multifocal Motor Neuropathy

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Multifocal Motor Neuropathy:

(show all 13)

- Elite gene

id	Symbol	Description	Score	Implication
1	CD1E	CD1e molecule	20.80	GeneCards inferred via : Publications (show sections)
2	CD1A	CD1a molecule	19.26	GeneCards inferred via : Publications (show sections)
3	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	17.72	GeneCards inferred via : Publications (show sections)
4	CNTN2	contactin 2 (axonal)	16.19	GeneCards inferred via : Publications (show sections)
5	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	14.65	GeneCards inferred via : Publications (show sections)
6	CD40LG	CD40 ligand	13.11	GeneCards inferred via : Publications (show sections)
7	BLK	B lymphoid tyrosine kinase	11.57	GeneCards inferred via : Publications (show sections)
8	SMN2	survival of motor neuron 2, centromeric	10.03	GeneCards inferred via : Publications (show sections)
9	BANK1	B-cell scaffold protein with ankyrin repeats 1	8.49	GeneCards inferred via : Publications (show sections)
10	IL4	interleukin 4	6.95	GeneCards inferred via : Publications (show sections)
11	IL10	interleukin 10	5.42	GeneCards inferred via : Publications (show sections)
12	IL2	interleukin 2	3.88	GeneCards inferred via : Publications (show sections)
13	IFNG	interferon, gamma	2.34	GeneCards inferred via : Publications (show sections)

Products for genes related to Multifocal Motor Neuropathy disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	13	-	13	13
2	Novus Biologicals	11	11	13	-

Variations for Multifocal Motor Neuropathy

Expression for genes affiliated with Multifocal Motor Neuropathy

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets, ³¹LifeMap Discovery®
See all sources

Genes differentially expressed in tissues of Multifocal Motor Neuropathy patients vs. healthy controls: ³¹ (show all 10)

id	Gene	Description	Tissue	Up/Dn	Fold Change (log2)	P value
1	HBB	hemoglobin, beta	Skeletal Muscle	-	2.18	0.042
2	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	Skeletal Muscle	+	2.15	0.012
3	HBA1	hemoglobin, alpha 1	Skeletal Muscle	-	2.06	0.020
4	HBA2	hemoglobin, alpha 2	Skeletal Muscle	-	2.06	0.020
5	SAT1	spermidine/spermine N1-acetyltransferase 1	Skeletal Muscle	+	1.90	0.049
6	MYLK2	myosin light chain kinase 2	Skeletal Muscle	-	1.70	0.014
7	NR1D1	nuclear receptor subfamily 1, group D, member 1	Skeletal Muscle	-	1.66	0.003
8	SNORD116-21	small nucleolar RNA, C/D box 116-21	Skeletal Muscle	-	1.58	0.014
9	CCDC80	coiled-coil domain containing 80	Skeletal Muscle	+	1.53	0.016
10	CIART	circadian associated repressor of transcription	Skeletal Muscle	-	1.33	0.030

Expression patterns in normal tissues for genes affiliated with Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ³⁰KEGG, ⁵⁹Thomson Reuters, ⁵³R&D Systems, ⁵²QIAGEN, ⁵Cell Signaling Technology
See all sources

Pathways related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 33)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	CD40/CD40L signaling³⁷	9.6	IL4, CD40LG
2	Hematopoietic cell lineage³⁰	9.4	CD1E, CD1A, IL4
3	B Cell Receptor Signaling Pathway³⁷	9.4	BLK, FCGR2B, BANK1
4	African trypanosomiasis³⁰	9.3	IL10, IFNG
5	Immune response MIF mediated glucocorticoid regulation⁵⁹	9.1	IL2, IFNG
6	IL12 signaling mediated by STAT4³⁷	9.1	IL2, IFNG
7	Tuberculosis³⁰	9.0	IL10, IFNG, FCGR2B
8	IL4-mediated signaling events³⁷	9.0	CD40LG, IL10, IL4
9	Malaria³⁰	9.0	CD40LG, IL10, IFNG
10	IL-9 Signaling Pathways⁵³ Show member pathways IL-21 Signaling Pathways⁵³ IL-9 Signaling Pathway³⁷ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways⁵³ Development Thrombopoietin regulated cell processes⁵⁹ IL-15 Signaling Pathways⁵³ IL-7 Signaling Pathways⁵³ Adipocytokines and Insulin Signaling⁵³ IL-7 Signaling Pathway³⁷ IL-2 Signaling Pathways⁵³ Immune response IL 9 signaling pathway⁵⁹ IL-4 Signaling Pathways⁵³ IL-9 Pathway⁵²	8.8	BLK, IL4, IL2
11	Glucocorticoid receptor regulatory network³⁷	8.6	IFNG, IL4, IL2
12	Spinal Cord Injury³⁷	8.6	IFNG, IL4, IL2
13	Immune response Role of DAP12 receptors in NK cells⁵⁹ Show member pathways Immune response CD16 signaling in NK cells⁵⁹ Natural killer cell mediated cytotoxicity³⁰	8.6	IFNG, IL4, IL2
14	IL12-mediated signaling events³⁷ Show member pathways Immune response IL 12 induced IFN gamma production⁵⁹	8.6	IL2, IL4, IFNG
15	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	8.5	IL10, IL2, IFNG
16	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	8.5	IL10, IL2, IFNG
17	Th1 Differentiation⁵³ Show member pathways IL27-mediated signaling events³⁷	8.5	IFNG, IL2, IL10
18	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	8.5	IL10, IL2, IFNG
19	Influenza A³⁰ Show member pathways Measles³⁰ Herpes simplex infection³⁰	8.3	FCGR2B, IFNG, IL4, IL2
20	Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷ Show member pathways Calcium signaling in the CD4+ TCR pathway³⁷	8.3	CD40LG, IL2, IL4, IFNG
21	Inflammatory Response Pathway³⁷	8.3	IFNG, IL4, IL2, CD40LG
22	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.2	IL10, IL2, IL4, PTPN22
23	Jak-STAT signaling pathway³⁰ Show member pathways Type III interferon signaling³⁷	8.0	IFNG, IL4, IL2, IL10
24	TGF-Beta Pathway⁵² Show member pathways SOCS Pathway⁵² JAK-STAT Pathway⁵² Regulation of eIF4 and p70S6K⁵² JNK Pathway⁵² MAPK Family Pathway⁵²	8.0	IFNG, IL4, IL2, IL10
25	Cytokines and Inflammatory Response³⁷	8.0	IL10, IL2, IL4, IFNG
26	Cytokine Network⁵²	8.0	IL10, IL2, IL4, IFNG
27	OX40 Pathway⁵²	8.0	IFNG, IL4, IL2, IL10
28	ErbB4 Pathway⁵² Show member pathways UVC-Induced MAPK Signaling⁵² FGF Pathway⁵² LPS Stimulated MAPK Signaling⁵² Growth Hormone Signaling⁵² HMGB1 Pathway⁵² PACAP Signaling⁵² IL-4 Pathway⁵² Prolactin Signaling⁵² Thrombopoietin Pathway⁵² ErbB2-ErbB3 Heterodimers⁵² IL-2 Pathway⁵² PI3K Signaling in B-Lymphocyte⁵² TREM1 Pathway⁵² ErbB Family Pathway⁵²	8.0	BLK, FCGR2B, IFNG, IL4, IL2
29	Lymphocyte Signaling⁵	7.8	BLK, PTPN22, IL4, IL2, IL10
30	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	7.6	IFNG, IL4, IL2, IL10, CD40LG
31	Leishmaniasis³⁰ Show member pathways Toxoplasmosis³⁰ Inflammatory bowel disease (IBD)³⁰	7.6	IFNG, IL4, IL2, IL10, CD40LG
32	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	7.6	IFNG, IL4, IL2, IL10, CD40LG
33	B Cell Receptor Signaling Pathway³⁷ Show member pathways B cell receptor signaling pathway³⁰ BCR signaling pathway³⁷ TCR Signaling Pathway³⁷ T cell receptor signaling pathway³⁰	7.4	CD40LG, IL10, IL2, IL4, IFNG, FCGR2B

Compounds for genes affiliated with Multifocal Motor Neuropathy

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ²⁵HMDB, ³BitterDB
See all sources

Compounds related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show top 50) (show all 91)

id	Compound	Score	Top Affiliating Genes
1	monomethyl fumarate⁴⁴	9.6	IL4, IL10
2	tdac⁴⁴	9.4	IL4, IL2
3	natalizumab⁴⁴ ¹²	10.4	FCGR2B, IFNG, IL10
4	daclizumab⁴⁴ ¹²	10.4	FCGR2B, CD40LG, IL2
5	alemtuzumab⁴⁴ ¹²	10.4	FCGR2B, CD40LG, IL2
6	adalimumab⁴⁴ ⁵⁰ ¹²	11.4	IFNG, IL10, FCGR2B
7	tuberculin⁴⁴	9.4	CD40LG, IFNG, IL10
8	praziquantel⁴⁴ ¹²	10.4	CD40LG, IL4, IL10
9	betaseron⁴⁴	9.2	IFNG, IL4, IL10
10	etanercept⁴⁴ ⁵⁰ ¹²	11.2	FCGR2B, IFNG, IL10
11	polymyxin b⁴⁴	9.1	IL4, IL10, IFNG
12	rolipram⁴⁴ ⁶⁰ ²⁹	11.0	IL4, IFNG, IL10
13	tarc⁴⁴	9.0	IL4, IFNG, IL10
14	infliximab⁴⁴ ⁵⁰ ¹²	10.9	IFNG, IL4, IL10
15	allergens⁴⁴	8.9	IL10, CD40LG, IL4, IFNG
16	rituximab⁴⁴ ⁵⁰ ¹²	10.8	FCGR2B, IL10, IL2, CD40LG
17	2,5-oligoadenylate⁴⁴	8.7	IL2, IL10, IFNG
18	ivig⁴⁴	8.6	FCGR2B, IL4, CD40LG, IFNG, IL10
19	herbimycin a⁴⁴ ⁶⁰	9.6	IFNG, IL4, IL2, CD40LG
20	mycophenolate mofetil⁴⁴ ⁵⁰ ¹²	10.6	IL10, IL2, IFNG, CD40LG
21	thalidomide⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.5	CD40LG, IL2, IFNG, IL10
22	biotin⁴⁴ ²⁵ ¹²	10.5	IL4, IL2, IL10, CD40LG
23	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	8.5	IFNG, IL4, IL10
24	ifn-alpha⁴⁴	8.5	IL10, IL2, IFNG
25	interferon gamma⁴⁴	8.4	IL10, IL2, IL4, IFNG
26	alpha-galactosylceramide⁴⁴	8.4	IFNG, IL4, IL2, IL10
27	glatiramer acetate⁴⁴ ¹²	9.4	IL4, IFNG, IL2, IL10
28	gm-csf⁴⁴ ²⁹	9.4	IL10, IFNG, IL2, IL4
29	con a⁴⁴	8.4	IL10, IL2, IL4, IFNG
30	polyinosinic-polycytidylic acid⁴⁴	8.4	IL4, IFNG, IL10, IL2
31	il 10⁴⁴	8.4	IFNG, IL4, IL2, IL10
32	pentoxifylline⁴⁴ ¹²	9.4	IL10, IFNG, IL2, IL4
33	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	11.3	IL2, IL4, IFNG, CD40LG
34	hydrocortisone⁴⁴ ³ ⁶⁰ ¹²	11.3	IL2, IFNG, IL4, IL10
35	tacrolimus⁴⁴ ⁵⁰ ¹²	10.3	IL10, IFNG, IL4, IL2
36	calcitriol⁴⁴ ⁶⁰ ²⁵ ¹²	11.2	IL10, IFNG, IL2, IL4
37	rapamycin⁴⁴	8.2	CD40LG, IL2, IFNG, IL10
38	il-12⁴⁴	8.1	IFNG, IL10, IL4, CD40LG, IL2
39	okt3⁴⁴	8.1	IFNG, CD40LG, IL10, IL2, IL4
40	ribavirin⁴⁴ ⁵⁰ ¹²	10.1	IL2, IL4, IL10, IFNG, CD40LG
41	neopterin⁴⁴	8.1	IL4, IFNG, IL10, CD40LG, IL2
42	rantes⁴⁴	8.0	IL2, IFNG, IL4, CD40LG, IL10
43	pge2⁴⁴	8.0	IL2, IFNG, CD40LG, IL10, IL4
44	cycloheximide⁴⁴	7.9	IL10, IL2, IL4, IFNG, CNTN2
45	thymidine⁴⁴ ²⁵	8.8	IL2, IFNG, IL4, IL10, CNTN2, FCGR2B
46	histamine⁴⁴ ²⁹ ²⁵	9.8	IL10, IL2, IL4, IFNG, FCGR2B, CD40LG
47	ionomycin⁴⁴	7.8	CNTN2, CD40LG, IFNG, IL4, IL2, IL10
48	cyclosporin a⁴⁴ ²⁹ ⁶⁰	9.8	IL10, IL2, IL4, IFNG, CD40LG, CNTN2
49	vegf⁴⁴	7.7	CD40LG, CNTN2, IL10, IL2, IL4, IFNG
50	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.5	IL4, CD40LG, IFNG, IL10, IL2

GO Terms for genes affiliated with Multifocal Motor Neuropathy

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	9.1	CD40LG, IL4, IFNG
2	extracellular space	GO:005615	7.3	CD40LG, IL10, IL2, IL4, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:048007	10.2	CD1E, CD1A
2	positive regulation of chemokine biosynthetic process	GO:045080	9.7	IL4, IFNG
3	regulation of isotype switching	GO:045191	9.6	IL4, IL10
4	type 2 immune response	GO:042092	9.6	IL10, IL4
5	positive regulation of interleukin-12 production	GO:032735	9.6	CD40LG, IFNG
6	defense response to protozoan	GO:042832	9.6	IFNG, IL4
7	regulation of immune response	GO:050776	9.6	FCGR2B, IL4, CD40LG
8	negative regulation of nitric oxide biosynthetic process	GO:045019	9.6	IL10, IL4
9	negative regulation of growth of symbiont in host	GO:044130	9.5	IL10, IFNG
10	B cell differentiation	GO:030183	9.3	IL4, IL10, CD40LG
11	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.2	IL4, IL2
12	T cell differentiation	GO:030217	9.2	PTPN22, IL2
13	B cell proliferation	GO:042100	9.2	CD40LG, IL10
14	positive regulation of activated T cell proliferation	GO:042104	9.2	IL2, IL4
15	positive regulation of MHC class II biosynthetic process	GO:045348	9.1	IL10, IL4, IFNG
16	positive regulation of isotype switching to IgG isotypes	GO:048304	8.9	IL2, IL4, IFNG
17	immune response	GO:006955	8.6	FCGR2B, IL4, IL2, CD1A, CD1E
18	negative regulation of apoptotic process	GO:043066	8.4	IL4, IL2, IL10, CD40LG
19	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	IL10, IL2, IL4, IFNG

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	exogenous lipid antigen binding	GO:030884	10.0	CD1A, CD1E
2	endogenous lipid antigen binding	GO:030883	10.0	CD1A, CD1E
3	lipopeptide binding	GO:071723	9.9	CD1E, CD1A
4	beta-2-microglobulin binding	GO:030881	9.7	CD1E, CD1A
5	growth factor activity	GO:008083	8.5	IL10, IL2, IL4
6	cytokine activity	GO:005125	7.8	CD40LG, IL10, IL2, IL4, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

Antibodies
Proteins
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Antibodies
Proteins
Kits and Assays

Sources for Multifocal Motor Neuropathy

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MMN MCID: MLT075 MIFTS: 53	Multifocal Motor Neuropathy (MMN) malady Rare diseases, Neuronal diseases categories
13 genes, 5 tissues, 103 related diseases, clinical trials Download this MalaCard Expand all tables

Multifocal Motor Neuropathy (MMN) malady