MCID: MLT075
MIFTS: 41

Multifocal Motor Neuropathy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

MalaCards integrated aliases for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 38 50 51 56 69
Multifocal Motor Neuropathy with Conduction Block 50 56
Mmncb 50 56
Mmn 50 56

Characteristics:

Orphanet epidemiological data:

56
multifocal motor neuropathy
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA641
UMLS via Orphanet 70 C0393847
ICD10 via Orphanet 34 G61.8

Summaries for Multifocal Motor Neuropathy

NIH Rare Diseases : 50 multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary : Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to amyotrophy, monomelic and neuropathy. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include testes, thyroid and b cells.

NINDS : 51 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia : 72 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 amyotrophy, monomelic 10.9
2 neuropathy 10.9
3 acute hemorrhagic encephalitis 10.3 CD40LG FCGR2B
4 lateral sclerosis 10.1
5 discitis 10.1 BLK CD40LG
6 peripheral nervous system disease 10.1 BLK CD40LG
7 mesenchymal cell neoplasm 10.1 CD40LG PTPN22
8 polyneuropathy 10.1
9 infertility 10.1 CNTN2 FCGR2B
10 neuronitis 10.0
11 lewis-sumner syndrome 10.0
12 polyradiculoneuropathy 10.0
13 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
14 demyelinating polyneuropathy 10.0
15 motor neuron disease 10.0
16 chronic inflammatory demyelinating polyneuropathy 10.0
17 dermatitis herpetiformis, familial 10.0 CD40LG PTPN22
18 muscular atrophy 9.9
19 progressive muscular atrophy 9.9
20 muscle hypertrophy 9.9
21 thyroiditis 9.9
22 mycoplasmal pneumonia 9.9 CD1A CD1E
23 lymphoma 9.8
24 respiratory failure 9.8
25 cervicitis 9.8
26 crohn's disease 9.7
27 axonal neuropathy 9.7
28 restless legs syndrome 9.7
29 amyloidosis 9.7
30 mononeuropathy 9.7
31 susac syndrome 9.7
32 acute motor axonal neuropathy 9.7
33 adenocarcinoma 9.7
34 rheumatoid arthritis 9.7
35 arthritis 9.7
36 b-cell lymphomas 9.7
37 spondylitis 9.7
38 actinic keratosis 9.5 BANK1 CD40LG FCGR2B PTPN22
39 pancreatic acinar cell adenocarcinoma 9.4 CD40LG SMN2
40 systemic lupus erythematosus 9.0 BANK1 BLK CD40LG FCGR2B PTPN22
41 myasthenia gravis 6.4 BANK1 BLK CD1A CD1E CD40LG CNTN2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to Multifocal Motor Neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Drugs & Therapeutics for Multifocal Motor Neuropathy

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 3,Phase 2
2 gamma-Globulins Phase 3,Phase 2
3 Pharmaceutical Solutions Phase 3
4 Immunoglobulins Phase 3,Phase 2
5 Immunoglobulins, Intravenous Phase 3,Phase 2
6 Antibodies Phase 3,Phase 2
7
Iron Approved 7439-89-6 23925
8 Antibodies, Anti-Idiotypic

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3 NPB-01
2 Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
3 LIME Study (LFB IVIg MMN Efficacy Study) Completed NCT01951924 Phase 3 Biological : I10E (Human normal Immunoglobulin for intravenous administration 100mg/mL);Biological: Kiovig® (Human normal Immunoglobulin for intravenous administration 100mg/mL)
4 Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy Completed NCT00268788 Phase 2 Subcutaneous immunoglobulin;Intravenous immunoglobulin
5 A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN) Completed NCT00701662 Phase 2
6 Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN) Enrolling by invitation NCT02556437 Phase 2 HyQvia;Subcuvia
7 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
8 sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN Unknown status NCT02271724
9 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678
10 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590 Immunoglobulins
11 A Study to Evaluate the Performance of a Diagnostic Test in ALS Recruiting NCT02759913
12 HyQvia in Multifocal Motor Neuropathy Not yet recruiting NCT02885259 rHuPH20
13 Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuro Not yet recruiting NCT03008733

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

39
Testes, Thyroid, B Cells, Lung, T Cells

Publications for Multifocal Motor Neuropathy

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 293)
id Title Authors Year
1
High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy. ( 28144763 )
2017
2
Nerve ultrasound as follow-up tool in treated multifocal motor neuropathy. ( 28681489 )
2017
3
Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. ( 28837908 )
2017
4
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. ( 27988478 )
2017
5
Teaching Video NeuroImages: Trapezius muscle hypertrophy in multifocal motor neuropathy. ( 28808176 )
2017
6
A comparative study of brachial plexus sonography and magnetic resonance imaging in chronic inflammatory demyelinating neuropathy and multifocal motor neuropathy. ( 28762574 )
2017
7
Immunoglobulin therapy in the treatment of multifocal motor neuropathy. ( 28320129 )
2017
8
Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy. ( 28717088 )
2017
9
High-Dose Subcutaneous Immunoglobulin in Patients With Multifocal Motor Neuropathy: A Nursing Perspective. ( 28885479 )
2017
10
Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review. ( 28644258 )
2017
11
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. ( 27040062 )
2016
12
Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. ( 27130524 )
2016
13
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. ( 27396516 )
2016
14
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. ( 27655303 )
2016
15
Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. ( 27400822 )
2016
16
Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. ( 27796190 )
2016
17
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. ( 27134672 )
2016
18
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. ( 27313890 )
2016
19
Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. ( 26991654 )
2016
20
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. ( 27571543 )
2016
21
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 27401495 )
2016
22
MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. ( 25736373 )
2015
23
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. ( 26280014 )
2015
24
The pathogenesis of multifocal motor neuropathy and an update on current management options. ( 25941538 )
2015
25
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. ( 25468269 )
2015
26
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. ( 26298317 )
2015
27
Multifocal Motor Neuropathy Associated with Infliximab. ( 26223843 )
2015
28
Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. ( 25592414 )
2015
29
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26218529 )
2015
30
Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26317434 )
2015
31
Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). ( 26329270 )
2015
32
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. ( 25739040 )
2015
33
Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 25976871 )
2015
34
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. ( 25626722 )
2015
35
Complement activity is associated with disease severity in multifocal motor neuropathy. ( 26161430 )
2015
36
Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. ( 25620065 )
2015
37
Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. ( 25695919 )
2015
38
Multifocal motor neuropathy: 30 years from onset to diagnosis. ( 26562827 )
2015
39
Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). ( 26477025 )
2015
40
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. ( 25549972 )
2015
41
Treatment of multifocal motor neuropathy. ( 24395647 )
2014
42
Relevance of muscle biopsy for diagnosing multifocal motor neuropathy. ( 24824273 )
2014
43
The node of Ranvier in multifocal motor neuropathy. ( 24801202 )
2014
44
Multifocal motor neuropathy: lost in conduction block? ( 24487379 )
2014
45
Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. ( 25181830 )
2014
46
Treatment of multifocal motor neuropathy with intravenous immunoglobulin. ( 24699885 )
2014
47
Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-BarrAc syndrome. ( 25157033 )
2014
48
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. ( 25130929 )
2014
49
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. ( 24741315 )
2014
50
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. ( 25283719 )
2014

Variations for Multifocal Motor Neuropathy

Expression for Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for Multifocal Motor Neuropathy

GO Terms for Multifocal Motor Neuropathy

Cellular components related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 CD1A CD1E CD40LG CNTN2

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 CD1A CD1E CD40LG FCGR2B
2 regulation of immune response GO:0050776 9.58 CD1A CD40LG FCGR2B
3 regulation of innate immune response GO:0045088 9.02 PTPN22
4 regulation of B cell receptor signaling pathway GO:0050855 8.96 PTPN22
5 negative regulation of interleukin-6 secretion GO:1900165 8.96 BANK1 PTPN22
6 negative regulation of B cell activation GO:0050869 8.85 BANK1
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.62 CD1A CD1E

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 9.26 CD1A CD1E
2 lipopeptide binding GO:0071723 9.16 CD1A CD1E
3 protein tyrosine kinase binding GO:1990782 9.02 PTPN22
4 endogenous lipid antigen binding GO:0030883 8.96 CD1A CD1E
5 exogenous lipid antigen binding GO:0030884 8.62 CD1A CD1E

Sources for Multifocal Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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