MCID: MLT075
MIFTS: 43

Multifocal Motor Neuropathy malady

Neuronal category

Summaries for Multifocal Motor Neuropathy

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards: Multifocal Motor Neuropathy is related to thyroiditis and arthritis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are Leishmaniasis and Hematopoietic cell lineage. The compounds pentoxifylline and Antithymocyte globulin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, lung and thyroid, and related mouse phenotypes are renal/urinary system and cellular.

NINDS:44 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:64 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

Sources:
43NIH Rare Diseases, 44NINDS, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

multifocal motor neuropathy 43 44 61


Related Diseases for Multifocal Motor Neuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Multifocal Motor Neuropathy family:

multifocal motor neuropathy with conduction block

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.6PTPN22
2arthritis30.2FCGR2B, IFNG, IL10, IL4, PTPN22
3n syndrome10.7
4axonal neuropathy10.6
5neuropathy, inflammatory demyelinating10.6
6motor peripheral neuropathy10.5
7lewis-sumner syndrome10.5
8lateral sclerosis10.5
9chronic inflammatory demyelinating polyradiculoneuropathy10.5
10amyotrophic lateral sclerosis10.5
11brachial plexus neuropathy10.5
12multifocal motor neuropathy with conduction block10.4
13guillain-barr� syndrome10.4
14chronic inflammatory demyelinating polyneuropathy10.3
15ankylosing spondylitis10.2
16restless legs syndrome10.2
17adenocarcinoma10.2
18amyloidosis10.2
19spondylitis10.2
20amyloid neuropathy10.2
21susac syndrome10.2
22amyloidosis, secondary10.2
23acute motor axonal neuropathy10.2
24letterer-siwe disease10.0CD1A
25histiocytosis10.0CD1A
26autoimmune hemolytic anemia10.0CD40LG
27guillain-barre syndrome10.0CD40LG
28leptospirosis10.0CD40LG
29rubella10.0CD40LG
30vasculitis10.0CD40LG
31measles10.0CD40LG
32sjogren's syndrome10.0CD40LG
33dengue hemorrhagic fever10.0CD40LG
34adult t-cell leukemia10.0CNTN2
35nephritis10.0CD40LG
36cryoglobulinemic vasculitis10.0CD40LG
37polyneuropathy10.0CD40LG
38herpes simplex10.0CNTN2
39cryoglobulinemia10.0CD40LG
40hemorrhagic fever10.0CD40LG
41antiphospholipid syndrome10.0CD40LG
42primary immunodeficiency disease10.0CD40LG
43celiac disease10.0PTPN22
44neuropathy10.0SMN2
45glomerulonephritis10.0CD40LG
46toxoplasmosis10.0CD40LG
47hepatitis10.0CD40LG
48macroglobulinemia, waldenstrom, somatic10.0CD40LG
49transitional cell carcinoma10.0CNTN2
50vitiligo10.0PTPN22

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Clinical Features for Multifocal Motor Neuropathy

Drugs & Therapeutics for Multifocal Motor Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Multifocal Motor Neuropathy

Drug clinical trials:

Search ClinicalTrials for Multifocal Motor Neuropathy

Search NIH Clinical Center for Multifocal Motor Neuropathy

Search CenterWatch for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

33
Smooth muscle, Lung, Thyroid, T cells, B cells

Animal Models for Multifocal Motor Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Multifocal Motor Neuropathy

Sources:
51PubMed
See all sources

Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Treatment of multifocal motor neuropathy. (24395647)
2014
2
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
3
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
4
Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier. (23926278)
2013
5
Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. (23642723)
2013
6
Pharmacokinetics of intravenous immunoglobulin in multifocal motor neuropathy. (24336791)
2013
7
Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies. (22105211)
2012
8
Multifocal motor neuropathy. (22019654)
2011
9
Immunotherapy of multifocal motor neuropathy. (21299437)
2011
10
Home-based IVIg treatment is convenient and time-saving in patients with multifocal motor neuropathy. (21692915)
2011
11
Multifocal motor neuropathy: update on clinical characteristics, pathophysiological concepts and therapeutic options. (20150737)
2010
12
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society--first revision. (21199100)
2010
13
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
14
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (19160219)
2009
15
Diagnosis and treatment of multifocal motor neuropathy. (18334133)
2008
16
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
17
Multifocal motor neuropathy with and without conduction block: a single entity? (17404204)
2007
18
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
19
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
20
High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)
2006
21
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
22
Lewis-Sumner syndrome and multifocal motor neuropathy. (15536613)
2005
23
129th ENMC International Workshop: Clinical Trials for Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy, 27th October 2004, Schiphol airport, The Netherlands. (15792873)
2005
24
Intravenous immunoglobulin for multifocal motor neuropathy. (15846714)
2005
25
Multifocal motor neuropathy. (15847844)
2005
26
Diagnosis of multifocal motor neuropathy. (15963442)
2005
27
Rituximab stabilizes multifocal motor neuropathy increasingly less responsive to IVIg. (15596777)
2004
28
Transcutaneous cervical root stimulation in the diagnosis of multifocal motor neuropathy with conduction block. (12933949)
2003
29
A misdiagnosis of multifocal motor neuropathy. (12849186)
2003
30
Multifocal motor neuropathy: clinical and immunological features and response to IVIg in relation to the presence and degree of motor conduction block. (12023421)
2002
31
Axonal multifocal motor neuropathy without conduction block or other features of demyelination. (11865141)
2002
32
Multifocal motor neuropathy presenting with respiratory failure. (11102916)
2000
33
Plasmapheresis in multifocal motor neuropathy: a case report. (10847795)
2000
34
Multifocal motor neuropathy: diagnostic criteria that predict the response to immunoglobulin treatment. (11117549)
2000
35
Multifocal motor neuropathy. (9443511)
1998
36
Contralateral early blink reflex in multifocal motor neuropathy. (9809229)
1998
37
Multifocal motor neuropathy without overt conduction block. (9466602)
1998
38
Deterioration of multifocal motor neuropathy after plasma exchange. (9596014)
1998
39
Amyotrophic lateral sclerosis and multifocal motor neuropathy with conduction block. (9395134)
1997
40
Multifocal motor neuropathy with conduction block after Campylobacter jejuni enteritis. (9040761)
1997
41
Criteria for early detection of conduction block in multifocal motor neuropathy (MMN): a study based on control populations and follow-up of MMN patients. (9402538)
1997
42
Acute multifocal motor neuropathy with early spontaneous recovery: a distinct syndrome from Guillain-BarrAc syndrome? (8654320)
1996
43
Persistent increased threshold of electrical stimulation selective to motor nerve in multifocal motor neuropathy. (8965834)
1996
44
Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study. (7673950)
1995
45
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
46
Clinical and neurophysiological assessment of immunoglobulin therapy in five patients with multifocal motor neuropathy. (7964850)
1994
47
Human immunoglobulin treatment of multifocal motor neuropathy and polyneuropathy associated with monoclonal gammopathy. (7964853)
1994
48
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
49
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
50
Immunosuppressive treatment in multifocal motor neuropathy. (1952828)
1991

Genetic Variations for Multifocal Motor Neuropathy

Expression for genes affiliated with Multifocal Motor Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CD40LG
29.4CD1A, CD1E, IL4
39.4FCGR2B, BLK, BANK1
49.3IL4, IL2
5
Hide members
9.0BLK, IL4, IL2
68.8CD40LG, IL10, IL4
78.8IL2, IL4, IFNG
8
Hide members
8.8IL2, IL4, IFNG
9
Hide members
8.5FCGR2B, IL2, IL4, IFNG
10
Hide members
8.5IFNG, IL4, IL2, FCGR2B
11
Development PDGF signaling via STATs and NF-kB
Hide members
8.5IL2, IL10, IFNG
12
Hide members
8.5IL2, IL10, IFNG
13
Hide members
8.5IL2, IL10, IFNG
148.5IFNG, CD40LG, IL4, IL2
15
Hide members
8.5IL2, IL4, CD40LG, IFNG
16
Hide members
8.3IFNG, CD40LG, IL10, IL4
17
Hide members
8.2IFNG, BLK, IL4, IL2, FCGR2B
188.0IFNG, IL10, IL4, IL2
198.0IFNG, IL10, IL4, IL2
208.0IL2, IL4, IL10, IFNG
217.8BLK, IL10, IL4, IL2, PTPN22
22
Hide members
7.4FCGR2B, IL2, IL4, IL10, CD40LG, IFNG

Compounds for genes affiliated with Multifocal Motor Neuropathy

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.4IL4
2Antithymocyte globulin119.9CD1A, FCGR2B
3glucuronoxylomannan459.8IL10
4vegf459.7IL10, CNTN2
5tdac459.7IL4, IL2
6daclizumab45 1110.6FCGR2B, IL2, CD40LG
7alemtuzumab45 1110.6CD40LG, IL2, FCGR2B
8gm-csf45 2910.6IFNG, IL10
9monomethyl fumarate459.5IL10, IL4
10bucillamine459.2IFNG, IL2
11natalizumab45 1110.2IFNG, IL10, FCGR2B
12acidophilus459.2IL4, IL10
13adalimumab45 50 1111.2FCGR2B, IL10, IFNG
14tuberculin459.2IL10, CD40LG, IFNG
15praziquantel45 1110.2CD40LG, IL10, IL4
16etanercept45 50 1111.1IFNG, IL10, FCGR2B
17betaseron459.0IFNG, IL10, IL4
18polymyxin b458.9IL4, IL10, IFNG
19rantes458.9IFNG, CD40LG, IL4, IL2
20infliximab45 50 1110.8IL4, IL10, IFNG
21rituximab45 50 1110.8FCGR2B, IL2, IL10, CD40LG
22tarc458.8IFNG, IL10, IL4
23herbimycin a45 609.8IFNG, CD40LG, IL4, IL2
242,5-oligoadenylate458.8IL2, IL10, IFNG
2515-deoxy-delta-12,14-prostaglandin j2458.8IFNG, IL10, IL4
26ifn-alpha458.7IL2, IL10, IFNG
27allergens458.7IFNG, CD40LG, IL10, IL4
28mycophenolate mofetil45 50 1110.6IFNG, CD40LG, IL10, IL2
29thalidomide45 50 60 1111.6IFNG, CD40LG, IL10, IL2
30biotin45 11 2410.5CD40LG, IL10, IL4, IL2
31chloroquine45 2 50 29 1112.5IL2, IL4, IL10
32ivig458.4IFNG, CD40LG, IL10, IL4, FCGR2B
33interferon gamma458.4IFNG, IL10, IL4, IL2
34alpha-galactosylceramide458.4IL2, IL4, IL10, IFNG
35glatiramer acetate45 119.4IFNG, IL10, IL4, IL2
36con a458.4IFNG, IL10, IL4, IL2
37polyinosinic-polycytidylic acid458.4IL2, IL4, IL10, IFNG
38il 10458.4IFNG, IL10, IL4, IL2
39tacrolimus45 50 1110.3IFNG, IL10, IL4, IL2
40calcitriol45 60 11 2411.2IL2, IL4, IL10, IFNG
41il-12458.1IL2, IL4, IL10, CD40LG, IFNG
42okt3458.1IFNG, CD40LG, IL10, IL4, IL2
43ribavirin45 50 1110.1IFNG, CD40LG, IL10, IL4, IL2
44neopterin458.1IFNG, CD40LG, IL10, IL4, IL2
45pge2458.0IFNG, CD40LG, IL10, IL4, IL2
46histamine45 29 249.8IFNG, CD40LG, IL10, IL4, IL2, FCGR2B
47ionomycin457.8IFNG, CNTN2, CD40LG, IL10, IL4, IL2
48thymidine45 248.8IFNG, CNTN2, IL10, IL4, IL2, FCGR2B
49cyclosporin a45 29 609.8IFNG, CNTN2, CD40LG, IL10, IL4, IL2
50dexamethasone45 50 29 1110.4IFNG, CD40LG, IL10, IL4, IL2

GO Terms for genes affiliated with Multifocal Motor Neuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7IL2, IL4, IL10, CD40LG, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:04800710.2CD1E, CD1A
2positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, IL4
3positive regulation of interleukin-12 productionGO:0327359.6CD40LG, IFNG
4regulation of immune responseGO:0507769.6FCGR2B, IL4, CD40LG
5defense response to protozoanGO:0428329.5IFNG, IL4
6B cell proliferationGO:0421009.5CD40LG, IL10
7regulation of isotype switchingGO:0451919.4IL4, IL10
8type 2 immune responseGO:0420929.4IL4, IL10
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3IL4, IL2
10negative regulation of nitric oxide biosynthetic processGO:0450199.3IL4, IL10
11negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG
12positive regulation of activated T cell proliferationGO:0421049.2IL2, IL4
13positive regulation of isotype switching to IgG isotypesGO:0483049.1IL2, IL4, IFNG
14B cell differentiationGO:0301839.1CD40LG, IL10, IL4
15positive regulation of MHC class II biosynthetic processGO:0453488.9IL4, IL10, IFNG
16immune responseGO:0069558.8CD1A, CD1E, IL4, IL2, FCGR2B
17negative regulation of apoptotic processGO:0430667.9CD40LG, IL10, IL4, IL2

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exogenous lipid antigen bindingGO:03088410.0CD1A, CD1E
2endogenous lipid antigen bindingGO:03088310.0CD1A, CD1E
3lipopeptide bindingGO:0717239.9CD1E, CD1A
4beta-2-microglobulin bindingGO:0308819.7CD1E, CD1A
5growth factor activityGO:0080838.5IL2, IL4, IL10
6cytokine activityGO:0051257.8IL2, IL4, IL10, CD40LG, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multifocal Motor Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet