MCID: MLT075
MIFTS: 49

Multifocal Motor Neuropathy malady

Rare diseases, Neuronal diseases categories
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Summaries for Multifocal Motor Neuropathy

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43NIH Rare Diseases, 44NINDS, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards: Multifocal Motor Neuropathy is related to demyelinating polyneuropathy and thyroiditis. An important gene associated with Multifocal Motor Neuropathy is CD1E (CD1e molecule), and among its related pathways are CD40/CD40L signaling and Hematopoietic cell lineage. The compounds monomethyl fumarate and tdac have been mentioned in the context of this disorder. Affiliated tissues include thyroid, b cells and lung, and related mouse phenotypes are renal/urinary system and liver/biliary system.

NINDS:44 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:65 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Aliases & Classifications for Multifocal Motor Neuropathy

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43NIH Rare Diseases, 44NINDS, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

multifocal motor neuropathy 43 44 62


Related Diseases for Multifocal Motor Neuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1demyelinating polyneuropathy30.8CNTN2, CD1E
2thyroiditis30.7PTPN22
3arthritis30.1IL10, IL4, IFNG, FCGR2B, PTPN22
4rheumatoid arthritis29.9FCGR2B, IL4, IL2, IFNG, CNTN2, CD40LG
5neuropathy11.4
6multifocal motor neuropathy with conduction block10.9
7lewis-sumner syndrome10.5
8lateral sclerosis10.5
9neuronitis10.5
10chronic inflammatory demyelinating polyradiculoneuropathy10.5
11amyotrophic lateral sclerosis10.5
12polyneuropathy10.5
13polyradiculoneuropathy10.5
14blindness10.5
15motor neuron disease10.4
16respiratory failure10.3
17chronic inflammatory demyelinating polyneuropathy10.3
18axonal neuropathy10.2
19ankylosing spondylitis10.2
20restless legs syndrome10.2
21adenocarcinoma10.2
22amyloidosis10.2
23cervicitis10.2
24lung adenocarcinoma10.2
25mononeuropathy10.2
26ophthalmoplegia10.2
27spondylitis10.2
28b-cell lymphomas10.2
29susac syndrome10.2
30acute motor axonal neuropathy10.2
31hemorrhagic fever10.1CD40LG
32periapical granuloma10.1IL4
33lupus erythematosus10.1FCGR2B, CD40LG
34intraocular lymphoma10.1IL10
35aspergillosis10.1IFNG
36leprosy10.1IL2
37systemic lupus erythematosus10.1BANK1, BLK
38immunodeficiency with hyper igm type 110.1CD40LG, IL4
39autosomal dominant hyper ige syndrome10.0IFNG, IL4
40cutaneous leishmaniasis10.0IFNG, IL10
41tuberculoid leprosy10.0IFNG, IL10
42malaria10.0IL10, IFNG
43t-cell large granular lymphocyte leukemia10.0IL2, CNTN2
44burkitt's lymphoma10.0CD40LG, FCGR2B, IL4
45systemic scleroderma10.0PTPN22, CD40LG, IL4
46relapsing-remitting multiple sclerosis10.0IL10, IFNG
47autoimmune thyroiditis10.0IL4, PTPN22, IFNG
48cerebral malaria10.0IL10, IFNG
49selective iga deficiency disease10.0CD40LG, IL10, IL4
50graves' disease10.0IL4, PTPN22, IFNG

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Multifocal Motor Neuropathy

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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33MalaCards
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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

33
Thyroid, B cells, Lung, Testes, T cells

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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37MGI
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Publications for Multifocal Motor Neuropathy

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52PubMed
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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
2
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
3
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
4
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
5
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
6
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
7
Multifocal motor neuropathy. (22019654)
2011
8
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
9
IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy. (20667861)
2011
10
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
11
Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)
2010
12
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
13
Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)
2009
14
Treatment of multifocal motor neuropathy with immunoglobulin: does route of administration matter? (19405192)
2009
15
Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. (19691531)
2009
16
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
17
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
18
What's new in multifocal motor neuropathy in 2007-2008? (19192064)
2008
19
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
20
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
21
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
22
Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system. (16554970)
2006
23
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
24
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
25
Multifocal motor neuropathy: current concepts and controversies. (15770650)
2005
26
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
27
Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)
2003
28
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
29
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
30
Consensus criteria for the diagnosis of multifocal motor neuropathy. (12508306)
2003
31
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
32
Multifocal motor neuropathy: long-term clinical and electrophysiological assessment of intravenous immunoglobulin maintenance treatment. (12135977)
2002
33
79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)
2001
34
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
35
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)
1999
36
Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)
1999
37
Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)
1999
38
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)
1999
39
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
40
Multifocal motor neuropathy. (9562669)
1998
41
AAEM case report #30: multifocal motor neuropathy. (8606689)
1996
42
Acute multifocal motor neuropathy with early spontaneous recovery: a distinct syndrome from Guillain-BarrAc syndrome? (8654320)
1996
43
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
44
Multifocal motor neuropathy: electrodiagnostic features. (8114790)
1994
45
Multifocal motor neuropathy. (8109909)
1994
46
Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)
1993
47
Multifocal motor neuropathy or CIDP? (8239574)
1993
48
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
49
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
50
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)
1988

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 54R&D Systems, 53QIAGEN, 5Cell Signaling Technology
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Pathways related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, IL4
29.4CD1A, IL4, CD1E
39.4BLK, FCGR2B, BANK1
49.3IFNG, IL10
59.1IFNG, IL2
69.1IL2, IFNG
79.0IL10, FCGR2B, IFNG
89.0IL4, IL10, CD40LG
99.0IFNG, IL10, CD40LG
10
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.8BLK, IL4, IL2
118.6IL2, IL4, IFNG
128.6IL4, IL2, IFNG
13
Show member pathways
Immune response CD16 signaling in NK cells60
8.6IL2, IFNG, IL4
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.6IL4, IFNG, IL2
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5IFNG, IL10, IL2
16
Show member pathways
IL27-mediated signaling events38
8.5IL2, IFNG, IL10
17
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5IFNG, IL2, IL10
18
Show member pathways
8.5IL2, IL10, IFNG
19
Show member pathways
8.3IL4, IFNG, FCGR2B, IL2
208.3CD40LG, IFNG, IL2, IL4
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.3IL4, IL2, IFNG, CD40LG
22
Show member pathways
8.2PTPN22, IL4, IL2, IL10
238.0IFNG, IL2, IL4, IL10
24
Show member pathways
8.0IL4, IL2, IL10, IFNG
258.0IFNG, IL4, IL2, IL10
268.0IL10, IL2, IL4, IFNG
27
Show member pathways
Type III interferon signaling38
8.0IL4, IFNG, IL10, IL2
28
Show member pathways
8.0FCGR2B, BLK, IFNG, IL4, IL2
297.8IL2, IL4, PTPN22, BLK, IL10
30
Show member pathways
7.6IFNG, CD40LG, IL10, IL2, IL4
31
Show member pathways
7.6IL10, IL2, IFNG, IL4, CD40LG
32
Show member pathways
7.6IL2, CD40LG, IL10, IFNG, IL4
33
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
7.4IL4, CD40LG, FCGR2B, IFNG, IL10, IL2

Compounds for genes affiliated with Multifocal Motor Neuropathy

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1monomethyl fumarate459.6IL4, IL10
2tdac459.4IL4, IL2
3natalizumab45 1110.4FCGR2B, IFNG, IL10
4daclizumab45 1110.4FCGR2B, CD40LG, IL2
5alemtuzumab45 1110.4FCGR2B, CD40LG, IL2
6adalimumab45 51 1111.4IFNG, IL10, FCGR2B
7tuberculin459.4CD40LG, IFNG, IL10
8praziquantel45 1110.4CD40LG, IL4, IL10
9betaseron459.2IFNG, IL4, IL10
10etanercept45 51 1111.2FCGR2B, IFNG, IL10
11polymyxin b459.1IL4, IL10, IFNG
12rolipram45 61 2911.0IL4, IFNG, IL10
13tarc459.0IL4, IFNG, IL10
14infliximab45 51 1110.9IFNG, IL4, IL10
15allergens458.9IL10, CD40LG, IL4, IFNG
16rituximab45 51 1110.8FCGR2B, IL10, IL2, CD40LG
172,5-oligoadenylate458.7IL2, IL10, IFNG
18ivig458.6FCGR2B, IL4, CD40LG, IFNG, IL10
19herbimycin a45 619.6IFNG, IL4, IL2, CD40LG
20mycophenolate mofetil45 51 1110.6IL10, IL2, IFNG, CD40LG
21thalidomide45 51 61 1111.5CD40LG, IL2, IFNG, IL10
22biotin45 24 1110.5IL4, IL2, IL10, CD40LG
2315-deoxy-delta-12,14-prostaglandin j2458.5IFNG, IL4, IL10
24ifn-alpha458.5IL10, IL2, IFNG
25interferon gamma458.4IL10, IL2, IL4, IFNG
26alpha-galactosylceramide458.4IFNG, IL4, IL2, IL10
27glatiramer acetate45 119.4IL4, IFNG, IL2, IL10
28gm-csf45 299.4IL10, IFNG, IL2, IL4
29con a458.4IL10, IL2, IL4, IFNG
30polyinosinic-polycytidylic acid458.4IL4, IFNG, IL10, IL2
31il 10458.4IFNG, IL4, IL2, IL10
32pentoxifylline45 119.4IL10, IFNG, IL2, IL4
33indomethacin45 29 61 1111.3IL2, IL4, IFNG, CD40LG
34hydrocortisone45 3 61 1111.3IL2, IFNG, IL4, IL10
35tacrolimus45 51 1110.3IL10, IFNG, IL4, IL2
36calcitriol45 61 24 1111.2IL10, IFNG, IL2, IL4
37rapamycin458.2CD40LG, IL2, IFNG, IL10
38il-12458.1IFNG, IL10, IL4, CD40LG, IL2
39okt3458.1IFNG, CD40LG, IL10, IL2, IL4
40ribavirin45 51 1110.1IL2, IL4, IL10, IFNG, CD40LG
41neopterin458.1IL4, IFNG, IL10, CD40LG, IL2
42rantes458.0IL2, IFNG, IL4, CD40LG, IL10
43pge2458.0IL2, IFNG, CD40LG, IL10, IL4
44cycloheximide457.9IL10, IL2, IL4, IFNG, CNTN2
45thymidine45 248.8IL2, IFNG, IL4, IL10, CNTN2, FCGR2B
46histamine45 29 249.8IL10, IL2, IL4, IFNG, FCGR2B, CD40LG
47ionomycin457.8CNTN2, CD40LG, IFNG, IL4, IL2, IL10
48cyclosporin a45 29 619.8IL10, IL2, IL4, IFNG, CD40LG, CNTN2
49vegf457.7CD40LG, CNTN2, IL10, IL2, IL4, IFNG
50dexamethasone45 51 29 1110.5IL4, CD40LG, IFNG, IL10, IL2

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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16Gene Ontology
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Cellular components related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CD40LG, IL4, IFNG
2extracellular spaceGO:0056157.3CD40LG, IL10, IL2, IL4, IFNG

Biological processes related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:04800710.2CD1E, CD1A
2positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
3regulation of isotype switchingGO:0451919.6IL4, IL10
4type 2 immune responseGO:0420929.6IL10, IL4
5positive regulation of interleukin-12 productionGO:0327359.6CD40LG, IFNG
6defense response to protozoanGO:0428329.6IFNG, IL4
7regulation of immune responseGO:0507769.6FCGR2B, IL4, CD40LG
8negative regulation of nitric oxide biosynthetic processGO:0450199.6IL10, IL4
9negative regulation of growth of symbiont in hostGO:0441309.5IL10, IFNG
10B cell differentiationGO:0301839.3IL4, IL10, CD40LG
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2IL4, IL2
12T cell differentiationGO:0302179.2PTPN22, IL2
13B cell proliferationGO:0421009.2CD40LG, IL10
14positive regulation of activated T cell proliferationGO:0421049.2IL2, IL4
15positive regulation of MHC class II biosynthetic processGO:0453489.1IL10, IL4, IFNG
16positive regulation of isotype switching to IgG isotypesGO:0483048.9IL2, IL4, IFNG
17immune responseGO:0069558.6FCGR2B, IL4, IL2, CD1A, CD1E
18negative regulation of apoptotic processGO:0430668.4IL4, IL2, IL10, CD40LG
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.0IL10, IL2, IL4, IFNG

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exogenous lipid antigen bindingGO:03088410.0CD1A, CD1E
2endogenous lipid antigen bindingGO:03088310.0CD1A, CD1E
3lipopeptide bindingGO:0717239.9CD1E, CD1A
4beta-2-microglobulin bindingGO:0308819.7CD1E, CD1A
5growth factor activityGO:0080838.5IL10, IL2, IL4
6cytokine activityGO:0051257.8CD40LG, IL10, IL2, IL4, IFNG

Products for genes affiliated with Multifocal Motor Neuropathy

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Sources for Multifocal Motor Neuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet