MCID: MLT075
MIFTS: 43

Multifocal Motor Neuropathy malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

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Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 32 45 46 51 65
Multifocal Motor Neuropathy with Conduction Block 45 51
 
Mmncb 45 51
Mmn 45 51

Characteristics:

Orphanet epidemiological data:

51
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 641
ICD10 via Orphanet28 G61.8
UMLS65 C0393847

Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:45 Multifocal motor neuropathy (mmn) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. mmn is thought to be due to an abnormal immune response, but the underlying cause is not clear. most people treated with intravenous immune globulin (ivig) have rapid improvement in weakness, but maintenance ivig is usually required for sustained improvement. last updated: 3/2/2016

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to neuropathy and fallopian tube carcinoma, and has symptoms including pathergy reaction An important gene associated with Multifocal Motor Neuropathy is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic cell lineage and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skeletal muscle, lung and breast.

NINDS:46 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia:68 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy11.0
2fallopian tube carcinoma10.4BLK, CD40LG
3peripheral nervous system disease10.4BLK, CD40LG
4membranous glomerulonephritis10.3BLK, CD40LG
5mycobacterium marinum10.3CD1A, CD1E
6dislocation of ear ossicle10.3CD1A, CD40LG
7lateral sclerosis10.2
8polyneuropathy10.2
9neuronitis10.2
10lewis-sumner syndrome10.2
11acute necrotizing encephalitis10.1CD40LG, FCGR2B
12motor neuron disease10.1
13polyradiculoneuropathy10.1
14chronic inflammatory demyelinating polyradiculoneuropathy10.1
15demyelinating polyneuropathy10.1
16chronic inflammatory demyelinating polyneuropathy10.0
17progressive muscular atrophy10.0
18thyroiditis10.0
19muscular atrophy10.0
20chronic kidney failure10.0CNTN2, FCGR2B
21muscle hypertrophy10.0
22lymphoma10.0
23respiratory failure10.0
24cervicitis10.0
25congenital dyserythropoietic anemia9.9CD40LG, PTPN22
26chronic polyneuropathy9.8CNTN2, FCGR2B
27hodgkin's lymphoma, lymphocytic depletion9.8CD40LG, FCGR2B
28rheumatoid arthritis9.8
29arthritis9.8
30b-cell lymphomas9.8
31crohn's disease9.8
32restless legs syndrome9.8
33mononeuropathy9.8
34adenocarcinoma9.8
35ophthalmoplegia9.8
36spondylitis9.8
37axonal neuropathy9.8
38amyloidosis9.8
39susac syndrome9.8
40acute motor axonal neuropathy9.8
41alcohol-induced mental disorder9.8CD40LG, PTPN22
42glycoproteinosis9.7CD40LG, PTPN22
43rh isoimmunization9.7CD40LG, PTPN22
44upper lip cancer9.7CD40LG, SMN2
45tonsil cancer9.1BANK1, CD40LG, FCGR2B, PTPN22
46systemic lupus erythematosus9.0BANK1, CD40LG, FCGR2B, PTPN22
47muscle disorders6.9BANK1, BLK, CD1A, CD1E, CD40LG, CNTN2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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UMLS symptoms related to Multifocal Motor Neuropathy:


pathergy reaction

Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3, Phase 2206
2Pharmaceutical SolutionsPhase 37004
3AntibodiesPhase 3, Phase 24477
4Immunologic FactorsPhase 3, Phase 218483
5Immunoglobulins, IntravenousPhase 3, Phase 2211
6ImmunoglobulinsPhase 3, Phase 24477
7Gamma-GlobulinsPhase 222
8
Ironapproved10217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.CompletedNCT01827072Phase 3
2Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor NeuropathyCompletedNCT00666263Phase 3
3LIME Study (LFB IVIg MMN Efficacy Study)Active, not recruitingNCT01951924Phase 3
4Subcutaneous Immunoglobulin Treatment for Multifocal Motor NeuropathyCompletedNCT00268788Phase 2
5A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)CompletedNCT00701662Phase 2
6Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)Not yet recruitingNCT02556437Phase 2
7Effect of Resistance and Aerobic Exercise in CIDP or MMNCompletedNCT02121678
8Immunoglobulin Dosage and Administration Form in CIDP and MMNCompletedNCT02111590
9sCD163 & CD19 as Candidate Biomarkers in CIDP and MMNRecruitingNCT02271724
10A Study to Evaluate the Performance of a Diagnostic Test in ALSRecruitingNCT02759913
11Change of Nerve Conduction Properties in IVIg Dependent NeuropathiesActive, not recruitingNCT01655394

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

33
Skeletal muscle, Lung, Breast, Prostate, T cells, Testes, Pituitary

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. (27040062)
2016
2
The pathogenesis of multifocal motor neuropathy and an update on current management options. (25941538)
2015
3
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. (25626722)
2015
4
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)
2014
5
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)
2014
6
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)
2014
7
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)
2014
8
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
9
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
10
A controlled trial of intravenous immunoglobulin in multifocal motor neuropathy. (24725024)
2013
11
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
12
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
13
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
14
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
15
Multifocal motor neuropathy. (22019654)
2011
16
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
17
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
18
Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)
2010
19
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
20
Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)
2009
21
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
22
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
23
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
24
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
25
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
26
High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)
2006
27
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
28
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
29
Multifocal motor neuropathy: current concepts and controversies. (15770650)
2005
30
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
31
Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)
2003
32
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
33
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
34
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
35
79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)
2001
36
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
37
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)
1999
38
Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)
1999
39
Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)
1999
40
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
41
Multifocal motor neuropathy. (9562669)
1998
42
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
43
AAEM case report #30: multifocal motor neuropathy. (8606689)
1996
44
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
45
Multifocal motor neuropathy: electrodiagnostic features. (8114790)
1994
46
Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)
1993
47
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
48
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
49
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)
1988
50

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 secretionGO:19001659.3BANK1, PTPN22

Sources for Multifocal Motor Neuropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet