MCID: MLT075
MIFTS: 38

Multifocal Motor Neuropathy malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Multifocal Motor Neuropathy

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Sources:
32LifeMap Discovery®, 45NIH Rare Diseases, 46NINDS, 51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 32 45 46 51 65
Multifocal Motor Neuropathy with Conduction Block 51
 
Mmncb 51
Mmn 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
multifocal motor neuropathy:
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Orphanet51 641
ICD10 via Orphanet28 G61.8

Summaries for Multifocal Motor Neuropathy

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NIH Rare Diseases:45 Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. people with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. it is typical for there to be differences from one side of the body to the other in the specific muscles involved. multifocal motor neuropathy is caused by abnormal activity of the body's immune system. while there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy. last updated: 5/1/2013

MalaCards based summary: Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to muscle disorders and neuropathy. An important gene associated with Multifocal Motor Neuropathy is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic cell lineage and . Affiliated tissues include skeletal muscle, thyroid and b cells.

NINDS:46 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Related Diseases for Multifocal Motor Neuropathy

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Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1muscle disorders28.5BANK1, BLK, CD1A, CD1E, CD40LG, CNTN2
2neuropathy11.4
3multifocal motor neuropathy with conduction block10.9
4lateral sclerosis10.6
5motor peripheral neuropathy10.5
6neuronitis10.5
7motor neuritis10.5
8neuritis10.5
9neuromuscular disease10.5
10peripheral nervous system disease10.5
11peripheral neuropathy10.5
12polyneuropathy10.5
13lewis-sumner syndrome10.5
14motor neuron disease10.5
15chronic inflammatory demyelinating polyradiculoneuropathy10.5
16demyelinating polyneuropathy10.5
17polyradiculoneuropathy10.5
18chronic inflammatory demyelinating polyneuropathy10.4
19progressive muscular atrophy10.4
20muscular atrophy10.4
21influenza10.4
22thyroiditis10.4
23muscle hypertrophy10.3
24respiratory failure10.3
25neurologic diseases10.3
26muscle tissue disease10.3
27myopathy10.3
28neuropathy, inflammatory demyelinating10.2
29critical illness polyneuropathy10.2
30autoimmune disease of blood10.2
31autoimmune disease of the nervous system10.2
32chronic polyneuropathy10.2
33demyelinating disease10.2
34hypersensitivity reaction type ii disease10.2
35rheumatoid arthritis10.2
36influenza, severe10.2
37deficiency anemia10.2
38arthritis10.2
39b-cell lymphomas10.2
40crohn's disease10.2
41hemolytic anemia10.2
42restless legs syndrome10.2
43axonal neuropathy10.2
44adenocarcinoma10.2
45amyloidosis10.2
46cervicitis10.2
47mononeuropathy10.2
48ophthalmoplegia10.2
49skin tag10.2
50spondylitis10.2

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to multifocal motor neuropathy

Symptoms for Multifocal Motor Neuropathy

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Drugs & Therapeutics for Multifocal Motor Neuropathy

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Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AlbunexPhase 3145
2Rho(D) Immune GlobulinPhase 3, Phase 2198
3Immunoglobulins, IntravenousPhase 3, Phase 2203
4Gamma-GlobulinsPhase 222

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy.CompletedNCT01827072Phase 3
2Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor NeuropathyCompletedNCT00666263Phase 3
3LIME Study (LFB IVIg MMN Efficacy Study)Active, not recruitingNCT01951924Phase 3
4Subcutaneous Immunoglobulin Treatment for Multifocal Motor NeuropathyCompletedNCT00268788Phase 2
5A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)CompletedNCT00701662Phase 2
6Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN)Not yet recruitingNCT02556437Phase 2
7Immunoglobulin Dosage and Administration Form in CIDP and MMNCompletedNCT02111590
8sCD163 & CD19 as Candidate Biomarkers in CIDP and MMNRecruitingNCT02271724
9Change of Nerve Conduction Properties in IVIg Dependent NeuropathiesActive, not recruitingNCT01655394
10Effect of Resistance and Aerobic Exercise in CIDP or MMNEnrolling by invitationNCT02121678

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Genetic Tests for Multifocal Motor Neuropathy

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Anatomical Context for Multifocal Motor Neuropathy

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MalaCards organs/tissues related to Multifocal Motor Neuropathy:

33
Skeletal muscle, Thyroid, B cells, T cells, Testes, Lung

Animal Models for Multifocal Motor Neuropathy or affiliated genes

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Publications for Multifocal Motor Neuropathy

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Articles related to Multifocal Motor Neuropathy:

(show top 50)    (show all 269)
idTitleAuthorsYear
1
The pathogenesis of multifocal motor neuropathy and an update on current management options. (25941538)
2015
2
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. (25626722)
2015
3
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. (25283719)
2014
4
Multifocal motor neuropathy: a review of pathogenesis, diagnosis, and treatment. (24741315)
2014
5
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy. (25130929)
2014
6
Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. (24862982)
2014
7
Immune pathogenesis and treatment of multifocal motor neuropathy. (22941513)
2013
8
Multifocal motor neuropathy: current therapies and novel strategies. (23516024)
2013
9
A controlled trial of intravenous immunoglobulin in multifocal motor neuropathy. (24725024)
2013
10
Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. (23762534)
2013
11
Brachial plexus cyst in a patient with multifocal motor neuropathy. (23857608)
2013
12
A case of multifocal motor neuropathy with conduction block associated with gastric and lung adenocarcinoma. (22734912)
2012
13
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
14
Multifocal motor neuropathy. (22019654)
2011
15
Activity-dependent conduction block in multifocal motor neuropathy. (21171095)
2011
16
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (20405181)
2010
17
Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. (20219211)
2010
18
Beneficial effect of rituximab monotherapy in multifocal motor neuropathy. (19467601)
2009
19
Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. (19236457)
2009
20
Treatment of multifocal motor neuropathy with immunoglobulin: does route of administration matter? (19405192)
2009
21
Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. (19691531)
2009
22
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
23
No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy. (18081911)
2008
24
Efficacy of intravenous immunoglobulin in multifocal motor neuropathy. (17911439)
2007
25
Multifocal motor neuropathy with conduction block: slow but not benign. (17172619)
2006
26
Multifocal motor neuropathy with and without conduction block: a single entity? (16924010)
2006
27
High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy. (16502421)
2006
28
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. (16034892)
2005
29
Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. (16043806)
2005
30
Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association. (15833429)
2005
31
Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. (12635114)
2003
32
Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. (12872332)
2003
33
Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. (14616962)
2003
34
Multifocal motor neuropathy and asymptomatic Hashimoto's thyroiditis: first report of an association. (12117481)
2002
35
79(th) ENMC International Workshop: multifocal motor neuropathy. 14-15 April 2000, Hilversum, The Netherlands. (11297948)
2001
36
Treatment of multifocal motor neuropathy with interferon-beta1A. (10751269)
2000
37
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. (10567092)
1999
38
Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy. (9988136)
1999
39
Multifocal motor neuropathy mimicking motor neuron disease: nine cases. (10540011)
1999
40
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? (10331352)
1999
41
Electrophysiologic findings in multifocal motor neuropathy. (9633785)
1998
42
Multifocal motor neuropathy. (9562669)
1998
43
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
44
AAEM case report #30: multifocal motor neuropathy. (8606689)
1996
45
T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-BarrAc syndrome and multifocal motor neuropathy in vitro. (8294565)
1994
46
Multifocal motor neuropathy: electrodiagnostic features. (8114790)
1994
47
Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin. (8429850)
1993
48
Intravenous immunoglobulin treatment in multifocal motor neuropathy. (1352598)
1992
49
Separating motor neuron diseases from pure motor neuropathies. Multifocal motor neuropathy with persistent conduction block. (1853773)
1991
50
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. (2843079)
1988

Variations for Multifocal Motor Neuropathy

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Expression for genes affiliated with Multifocal Motor Neuropathy

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Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for genes affiliated with Multifocal Motor Neuropathy

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Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD1A, CD1E
2
B Cell Receptor Signaling Pathway (WikiPathways)
Show member pathways
9.1CD1A, CD1E
39.0BLK, CD40LG, PTPN22

GO Terms for genes affiliated with Multifocal Motor Neuropathy

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Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation, exogenous lipid antigen via MHC class IbGO:004800710.0CD1A, CD1E
2negative regulation of interleukin-6 secretionGO:19001659.8BANK1, PTPN22
3T cell differentiationGO:00302179.6BLK, PTPN22
4immune responseGO:00069558.7CD1A, CD1E, CD40LG, FCGR2B

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-2-microglobulin bindingGO:00308819.6CD1A, CD1E
2lipopeptide bindingGO:00717239.6CD1A, CD1E
3endogenous lipid antigen bindingGO:00308839.5CD1A, CD1E
4exogenous lipid antigen bindingGO:00308849.3CD1A, CD1E

Sources for Multifocal Motor Neuropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet