MCID: MLT008
MIFTS: 33

Multinodular Goiter malady

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Multinodular Goiter

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Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 10 47 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:0050489
UMLS65 C0342208

Summaries for Multinodular Goiter

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Disease Ontology:10 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary: Multinodular Goiter is related to thyroiditis and corneal ectasia. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Endothelin and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, lung and t cells, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Related Diseases for Multinodular Goiter

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Diseases in the Multinodular Goiter family:

Familial Multinodular Goiter

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 286)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.0TG, TPO, TSHR
2corneal ectasia30.0CALCA, TG
3familial multinodular goiter12.6
4goiter, multinodular 1, with or without sertoli-leydig cell tumors11.9
5daneman davy mancer syndrome11.8
6graves' disease11.6
7cln4 disease11.6
8short stature, microcephaly, and endocrine dysfunction10.7
9thyroid cancer, nonmedullary, 410.6
10breast cancer10.5
11endotheliitis10.5
12leukemia10.4
13hyperthyroidism, nonautoimmune10.4GNAS, TSHR
14prostatitis10.4
15prostate cancer10.3
16hepatitis10.3
17lymphoma10.3
18sarcoma10.3
19neuronitis10.3
20embryoma10.3DICER1, NKX2-1
21colorectal cancer10.2
22alopecia10.2
23follicular lymphoma10.2
24pulmonary sarcoidosis10.2
25heart disease10.2
26dysentery10.2
27dementia10.2
28porphyria10.2
29hypothyroidism10.2
30adenocarcinoma10.2
31ischemia10.2
32laryngitis10.2
33pancreatitis10.2
34lipodystrophy10.2
35neuropathy10.2
36glioblastoma10.2
37cardiomyopathy10.2
38anoxia10.2
39pleural mesothelioma10.2
40bone inflammation disease10.2CALCA, GNAS
41portal hypertension10.2CALCA, CP
42linear and whorled nevoid hypermelanosis10.1GSR, TPO
43tonsillar fossa cancer10.1CP, GNAS
44postpoliomyelitis syndrome10.1CALCA, NKX2-1
45autoimmune thyroiditis10.1TG, TPO
46thyroid ectopia10.1TG, TPO
47neonatal meningitis10.1TG, TPO
48schizophrenia10.1
49neuroblastoma10.1
50systemic lupus erythematosus10.1

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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Drugs & Therapeutics for Multinodular Goiter

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Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AutoantibodiesPhase 4117
2HemostaticsPhase 2, Phase 31082
3CoagulantsPhase 2, Phase 31042
4HormonesPhase 2, Phase 111748
5Anesthetics7385
6
Iodine4947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
7cadexomer iodine456

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1The Role of Levothyroxine on Goiter With Atypia of Undetermined SignificanceNot yet recruitingNCT02329379Phase 4
2Clinical Trial on Harmonic Focus ShearsCompletedNCT01003652Phase 2, Phase 3
3Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular GoiterCompletedNCT00454220Phase 2
4rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
5rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
6Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating HormoneCompletedNCT00137891Phase 1
7Three-Year Follow-up of Radioiodine Therapy for GoitreCompletedNCT00509483
8Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft FunctionCompletedNCT02194920
9A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid SurgeryCompletedNCT01163565
10Swallowing Function Before and After Surgery for Thyroid GoiterCompletedNCT00205348
11Thyroid Lobectomy With or Without Levothyroxine Treatment PostoperativelyCompletedNCT00941551
12Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid DiseaseCompletedNCT00666315
13Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid NodulesCompletedNCT00571090
14Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
15Budget Impact of Harmonic FOCUS in ThyroidectomyActive, not recruitingNCT01658085
16Galectin 3 Dosage in Diagnosis of Nodular and Multinodular GoiterActive, not recruitingNCT01588288
17Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid CancerWithdrawnNCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

33
Thyroid, Lung, T cells, Prostate, Brain, Breast, Bone

Animal Models for Multinodular Goiter or affiliated genes

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MGI Mouse Phenotypes related to Multinodular Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.8DICER1, GNAS, HRAS, NKX2-1, SLC26A4, TPO
2MP:00053797.8DICER1, GNAS, HRAS, NKX2-1, SLC26A4, TG
3MP:00053867.6CP, DICER1, GNAS, HRAS, NKX2-1, SLC26A4
4MP:00036317.1CP, DICER1, GNAS, HRAS, NKX2-1, SLC26A4
5MP:00053766.7CP, DICER1, GNAS, HRAS, NKX2-1, SLC26A4

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Investigation of asthma comorbidity in children with different severities of allergic rhinitis. (27216348)
2016
2
Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3. (25096929)
2014
3
Minimally invasive repair of posterior leaflet mitral valve prolapse with the "respect" approach. (24349991)
2013
4
Symptomatic progression of degenerative scoliosis after decompression and limited fusion surgery for lumbar spinal stenosis. (23274034)
2013
5
See me, feel me. Using physiology to validate behavioural observations of emotions of people with severe or profound intellectual disability. (23464864)
2013
6
Thymoma originating in a giant thymolipoma: a rare intrathoracic lesion. (23992709)
2013
7
Cultural stereotypes and personal beliefs about individuals with dwarfism. (23421007)
2013
8
Comparison of methodologies for analysing the progression of joint destruction in rheumatoid arthritis. (23425151)
2013
9
Evaluation of Topical Black Seed Oil in the Treatment of Allergic Rhinitis. (23855426)
2013
10
Increased expression of atrogenes and TWEAK family members after severe burn injury in nonburned human skeletal muscle. (23816995)
2013
11
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
12
Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. (22422617)
2012
13
Pulmonary function and left ventricular mass in African Americans: the Atherosclerosis Risk in Communities (ARIC) study. (22044673)
2012
14
Oncogenic potential of yin yang 1 mediated through control of imprinted genes. (22248054)
2011
15
Defining natural history: assessment of the ability of college students to aid in characterizing clinical progression of Niemann-Pick disease, type C. (21984891)
2011
16
Effect of thalidomide on nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells. (20514789)
2010
17
Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas. (19224763)
2009
18
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. (19701206)
2009
19
Serum thyroglobulin measurement in the follow-up of patients treated for differentiated thyroid cancer. (19910901)
2009
20
Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene. (19539840)
2009
21
Expression of reversion-inducing cysteine-rich protein with Kazal motifs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus: links to disease activity, damage accrual and matrix metalloproteinase 9 secretion. (18652766)
2008
22
Amyloid-beta dynamics correlate with neurological status in the injured human brain. (18755980)
2008
23
Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. (19008643)
2008
24
Ras oncogenes and their downstream targets. (17428555)
2007
25
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro. (18025282)
2007
26
Enzymes as a special class of therapeutic target: clinical drugs and modes of action. (17884461)
2007
27
Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells. (17001349)
2007
28
Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. (17094486)
2006
29
Effect of fetal position on second-stage duration and labor outcome. (15802403)
2005
30
Interaction of SP-A (surfactant protein A) with bacterial rough lipopolysaccharide (Re-LPS), and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding protein. (15932345)
2005
31
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. (15567511)
2005
32
NOTCH4 and the frontal lobe in schizophrenia. (12627456)
2003
33
Nailing down a link between tuberin and renal cysts. (12547695)
2003
34
Effects of sex steroid hormones and menopause on serum leptin concentrations. (12626035)
2002
35
The outcome and analysis of 40 cases of fetal gastroschisis. (12370717)
2002
36
Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. (12032359)
2002
37
Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation. (11244168)
2001
38
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor. (11368952)
2001
39
Spontaneous perirenal hematoma as the initial manifestation of polyarteritis nodosa and long-term follow-up without treatment. (10867546)
2000
40
Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. (9326671)
1997
41
IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. (8617936)
1996
42
Fusion protein mediated prodrug activation (FMPA) in vivo. (7736540)
1994
43
Transient analysis for antiproliferative gene activity. (2300576)
1990
44
Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone. (2124140)
1990
45
Glutaric aciduria in progressive choreo-athetosis. (624191)
1978
46
Isolated small bowel obstruction as the presenting feature of colonic disease. (880024)
1977
47
IX. Helminthiasis. Trematode infections and cestode infections. (4614512)
1974
48
A case of coexisting duodenal uceration and idiopathic steatorrhea. (5686665)
1968
49
Pigmentary retinopathy in patients receiving high doses of a new phenothiazine. (13843390)
1960
50
Macular edema, papilledema, and optic atrophy after cataract extraction. (13519990)
1958

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1iodide transportGO:001570510.0SLC26A4, TG
2hormone biosynthetic processGO:004244610.0TG, TPO
3thyroid gland developmentGO:00308789.8NKX2-1, TG
4thyroid hormone generationGO:00065909.8TG, TPO
5positive regulation of cAMP biosynthetic processGO:00308199.6CALCA, GNAS
6activation of adenylate cyclase activityGO:00071909.6CALCA, TSHR
7cellular oxidant detoxificationGO:00988699.5GSR, TPO
8feeding behaviorGO:00076319.2CALCA, NKX2-1

Sources for Multinodular Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet