MCID: MLT008
MIFTS: 44

Multinodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

MalaCards integrated aliases for Multinodular Goiter:

Name: Multinodular Goiter 12 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050489
UMLS 69 C0342208

Summaries for Multinodular Goiter

Disease Ontology : 12 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary : Multinodular Goiter is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and graves' disease. An important gene associated with Multinodular Goiter is MNG3 (Multinodular Goiter-3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Longevity regulating pathway. The drugs Autoantibodies and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 72 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Related Diseases for Multinodular Goiter

Diseases in the Multinodular Goiter family:

Goiter, Multinodular 2 Goiter, Multinodular 3

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.2 DICER1 TG TPO
2 graves' disease 32.4 GNAS TG TPO TSHR
3 thyroiditis 31.0 CALCA TG TPO TSHR
4 graves disease 1 30.8 TG TPO TSHR
5 hyperthyroidism 30.7 GNAS TG TPO TSHR
6 plummer's disease 30.7 TG TPO
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.4 TG TPO TSHR
8 hyperthyroxinemia 30.3 TPO TSHR
9 suppurative thyroiditis 30.0 CALCA TG
10 endemic goiter 29.8 CALCA TG TPO TSHR
11 thyroid cancer, anaplastic 29.7 NKX2-1 PAX8 TG
12 nodular goiter 29.5 CALCA TG TPO TSHR
13 congenital hypothyroidism 28.9 NKX2-1 PAX8 TG TPO TSHR
14 goiter 28.9 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
15 papillary carcinoma 28.8 CALCA NKX2-1 PAX8 TG TPO TSHR
16 hypothyroidism 28.7 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
17 thyroid cancer, nonmedullary, 1 28.3 CALCA HRAS NKX2-1 PAX8 TG TPO
18 follicular adenoma 28.2 CALCA NKX2-1 PAX8 TG TPO TSHR
19 differentiated thyroid carcinoma 28.0 DICER1 HRAS NKX2-1 PAX8 TG TPO
20 thyroid cancer, nonmedullary, 2 28.0 CALCA HRAS NKX2-1 PAX8 TG TPO
21 thyroid cancer 27.5 CALCA GNAS HRAS NKX2-1 PAX8 SLC26A4
22 daneman davy mancer syndrome 12.0
23 goiter, multinodular, cystic renal disease, and digital anomalies 11.3
24 goiter, multinodular 2 11.3
25 goiter, multinodular 3 11.3
26 short stature, microcephaly, and endocrine dysfunction 11.3
27 thyroid cancer, nonmedullary, 4 11.1
28 myopathy - thyrotoxic 11.1
29 hypothyroidism, congenital, nongoitrous, 1 10.5 GNAS TSHR
30 familial thyroid dyshormonogenesis 10.5 TG TPO
31 subacute lymphocytic thyroiditis 10.4 TG TPO
32 adenoma 10.4
33 congenital rubella 10.4 CAT TPO
34 ovarian germ cell teratoma 10.3 NKX2-1 TG
35 premature menopause 10.3 TG TPO
36 ovarian germ cell cancer 10.3 NKX2-1 TG
37 hypothyroidism, congenital, nongoitrous, 4 10.3 TG TPO
38 meningitis and encephalitis 10.3 CAT SOD1
39 malignant teratoma 10.3 NKX2-1 TG
40 myxedema 10.3 TG TPO TSHR
41 subacute thyroiditis 10.3 TG TPO TSHR
42 autoimmune disease of endocrine system 10.3 TG TPO TSHR
43 hypersensitivity reaction disease 10.3 TG TPO TSHR
44 parathyroid adenoma 10.3
45 pernicious anemia 10.3 TG TPO
46 pulmonary blastoma 10.2 DICER1 NKX2-1
47 struma ovarii 10.2 NKX2-1 TG TSHR
48 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 TG TPO
49 primary hyperparathyroidism 10.2
50 hyperparathyroidism 10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to Multinodular Goiter

Symptoms & Phenotypes for Multinodular Goiter

MGI Mouse Phenotypes related to Multinodular Goiter:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 TSHR XRCC4 PAX8 DICER1 SLC26A4 GNAS
2 growth/size/body region MP:0005378 10.07 TSHR XRCC4 TPO NKX2-1 PAX8 DICER1
3 homeostasis/metabolism MP:0005376 10.03 TSHR XRCC4 TPO NKX2-1 CAT PAX8
4 craniofacial MP:0005382 9.91 XRCC4 TPO PAX8 DICER1 GNAS HRAS
5 hearing/vestibular/ear MP:0005377 9.8 TSHR TPO PAX8 SLC26A4 GNAS SOD1
6 neoplasm MP:0002006 9.76 TSHR XRCC4 CAT DICER1 GNAS SOD1
7 nervous system MP:0003631 9.65 TSHR XRCC4 NKX2-1 PAX8 DICER1 SLC26A4
8 skeleton MP:0005390 9.32 TSHR XRCC4 TPO NKX2-1 PAX8 DICER1

Drugs & Therapeutics for Multinodular Goiter

Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Phase 4
2 Coagulants Phase 2, Phase 3
3 Hemostatics Phase 2, Phase 3
4
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
5 Hormones Phase 2,Phase 1
6 Bone Density Conservation Agents Phase 2
7 calcitonin Phase 2
8 Calcitonin Gene-Related Peptide Phase 2
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11
Iodine Approved, Investigational 7553-56-2 807
12 cadexomer iodine
13 Anesthetics

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
3 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
4 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
5 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
6 Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1 Modified Release rhTSH
7 Budget Impact of Harmonic FOCUS in Thyroidectomy Unknown status NCT01658085
8 Three-Year Follow-up of Radioiodine Therapy for Goitre Completed NCT00509483
9 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288
10 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
11 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565
12 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease Completed NCT00666315
13 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
14 Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
15 Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules Completed NCT00571090
16 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
17 Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer Withdrawn NCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Genetic tests related to Multinodular Goiter:

# Genetic test Affiliating Genes
1 Multinodular Goiter 28

Anatomical Context for Multinodular Goiter

MalaCards organs/tissues related to Multinodular Goiter:

38
Thyroid, Bone, Lung, Colon, Pituitary, Trachea, Endothelial

Publications for Multinodular Goiter

Articles related to Multinodular Goiter:

(show top 50) (show all 328)
# Title Authors Year
1
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
2
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
3
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
4
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
5
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
6
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
7
Airway Considerations in Case of a Large Multinodular Goiter. ( 29284884 )
2017
8
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
9
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
10
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
11
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
12
Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis. ( 29442060 )
2017
13
Neglected nontoxic multinodular goiter presented as a large neck mass. ( 28265406 )
2017
14
Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. ( 28506088 )
2017
15
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
16
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? ( 28005977 )
2016
17
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. ( 27988915 )
2016
18
Prominent Cold Nodule in Multinodular Goiter Revealed to Be Thyrolipoma: A Case Report. ( 28974966 )
2016
19
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. ( 26871832 )
2016
20
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
21
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
22
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
23
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
24
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
25
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
26
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
27
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
28
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
29
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
30
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
31
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
32
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
33
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
34
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. ( 26982637 )
2016
35
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
36
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? ( 26702247 )
2015
37
Large multinodular goiter--outpatient radioiodine treatment. ( 26323466 )
2015
38
The Natural History of Multinodular Goiter. ( 26364072 )
2015
39
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. ( 25981745 )
2015
40
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. ( 26319784 )
2015
41
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? ( 25594634 )
2015
42
Thyroid storm associated with multinodular goiter: a difficult problem to treat. ( 25772969 )
2015
43
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. ( 27011525 )
2015
44
Trigeminal autonomic headaches caused by a multinodular goiter--a case report. ( 24628230 )
2014
45
Congenital thyroid hemiagenesis with multinodular goiter. ( 25379177 )
2014
46
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. ( 25189867 )
2014
47
Toxic multinodular goiter in a patient with end-stage renal disease and hemodialysis. ( 25089233 )
2014
48
Adenomatous multinodular goiter causing airway obstruction in an infant. ( 24622964 )
2014
49
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. ( 24555692 )
2014
50
Multinodular Goiter in children: an important pointer to a germline DICER1 mutation. ( 24628552 )
2014

Variations for Multinodular Goiter

Expression for Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for Multinodular Goiter

GO Terms for Multinodular Goiter

Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.7 CAT SOD1 TPO
2 cellular response to oxidative stress GO:0034599 9.65 CAT GSR SOD1
3 cellular oxidant detoxification GO:0098869 9.58 CAT GSR TPO
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.54 CALCA GNAS TSHR
5 hydrogen peroxide catabolic process GO:0042744 9.51 CAT TPO
6 positive regulation of cAMP biosynthetic process GO:0030819 9.5 CALCA GNAS TSHR
7 response to reactive oxygen species GO:0000302 9.49 CAT SOD1
8 hormone biosynthetic process GO:0042446 9.46 TG TPO
9 positive regulation of adenylate cyclase activity GO:0045762 9.43 CALCA TSHR
10 activation of adenylate cyclase activity GO:0007190 9.33 CALCA GNAS TSHR
11 iodide transport GO:0015705 9.26 SLC26A4 TG
12 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
13 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 9.16 CAT SOD1
2 peroxidase activity GO:0004601 8.96 CAT TPO
3 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Multinodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....