MCID: MLT008
MIFTS: 47

Multinodular Goiter malady

Summaries for Multinodular Goiter

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A multinodular goiter is a multinodular enlargment of the thyroid gland. more...

MalaCards: Multinodular Goiter is related to goiter and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and trachea, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Description from OMIM:46 138800

Aliases & Classifications for Multinodular Goiter

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8Disease Ontology, 44Novoseek, 60UMLS, 46OMIM
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Aliases & Descriptions:

multinodular goiter 8 44 60


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Disease Ontology8 DOID:0050489
OMIM46 138800

Related Diseases for Multinodular Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Multinodular Goiter family:

Goiter, Multinodular, 3 Goiter, Multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1goiter32.0TG, TPO, TSHR, SLC26A4, TRH, NKX2-1
2thyroiditis31.6TG, TPO, TSHR, TRH, CALCA
3nontoxic goiter31.1TSHR, TPO, TG
4graves' disease31.0TSHR, GNAS
5thyroid cancer30.9TG, TPO, TSHR, KRT19, SLC26A4, TRH
6hyperthyroidism30.9GNAS, TRH, TSHR, ADCY10, TPO, TG
7papillary carcinoma30.9TPO, ADCY10, TSHR, KRT19, SLC26A4, NKX2-1
8adenoma30.9HSPG2, VHL, CALCA, GNAS, NKX2-1, TRH
9papillary thyroid carcinoma30.9TG, TPO, TSHR
10endemic goiter30.7TSHR, TPO, TG
11thyrotoxicosis30.7TRH, TSHR, TPO, TG
12parathyroid adenoma30.7GNAS, CALCA
13hyperparathyroidism30.7ADCY10, CALCA
14follicular thyroid carcinoma30.5CALCA, TSHR, ADCY10, TG
15plummer's disease30.4TPO, TG
16leydig cell tumor30.4ADCY10, GNAS
17nodular goiter30.4CALCA, KRT19, TSHR, TPO, TG
18hypothyroidism30.4GNAS, NKX2-1, TRH, SLC26A4, TSHR, ADCY10
19thymoma30.1NKX2-1
20hypoparathyroidism30.1CALCA
21lung cancer30.1NKX2-1, KRT19
22fibrous dysplasia30.1GNAS, ADCY10
23renal clear cell carcinoma30.1VHL
24hyperthyroxinemia30.1TRH, TSHR, TPO
25acromegaly30.1ADCY10, TRH, GNAS
26tuberculosis30.1CP, TPO, ADCY10
27obesity30.1ADCY10, TRH, GNAS
28congenital hypothyroidism30.1GNAS, NKX2-1, TSHR, TPO, TG
29melanoma30.1HSPG2, NKX2-1, TSHR, CP, TGFB3
30primary hyperparathyroidism10.5
31daneman davy mancer syndrome10.4
32substernal goiter10.4
33goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
34sertoli-leydig cell tumor10.3
35sertoli cell tumor10.3
36horner's syndrome10.3
37renal cell carcinoma10.3
38lingual goiter10.1
39acute thyroiditis10.1
40suppurative thyroiditis10.1
41parathyroid carcinoma10.1
42colon lymphoma10.1
43bone carcinoma10.1
44mccune albright syndrome10.1
45thyroid lymphoma10.1
46allergic rhinitis10.1
47cellulitis10.1
48alveolar rhabdomyosarcoma10.1
49pemphigus10.1
50extramedullary plasmacytoma10.1

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Clinical Features for Multinodular Goiter

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46OMIM
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Clinical features from OMIM:

138800

Drugs & Therapeutics for Multinodular Goiter

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Multinodular Goiter

Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Search CenterWatch for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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32MalaCards
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MalaCards organs/tissues related to Multinodular Goiter:

32
Thyroid, Bone, Trachea, T cells, Pituitary, Colon, Lung, Breast, Heart, Endothelial, Lymph node, Salivary gland

Animal Models for Multinodular Goiter or affiliated genes

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36MGI
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Publications for Multinodular Goiter

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50PubMed
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Articles related to Multinodular Goiter:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter. (23264145)
2013
2
Overview of thyroid physiology: an essential for understanding familial euthyroid multinodular goiter. (23882995)
2013
3
Combination therapy of temporary tracheal stenting and radiofrequency ablation for multinodular thyroid goiter with airway compression. (24043977)
2013
4
Familial multinodular goiter syndrome with papillary thyroid carcinomas: mutational analysis of the associated genes in 5 cases from 1 Chinese family. (24144365)
2013
5
Prevalence of Thyroid Cancer in Multinodular Goiter Versus Single Nodule: Iodine Intake and Cancer Phenotypes. (23991912)
2013
6
Minimally invasive follicular thyroid carcinoma developed in dyshormonogenetic multinodular goiter due to thyroid peroxidase gene mutation. (22435912)
2012
7
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. (22302284)
2012
8
Reduction in relapse rate of radioiodine therapy in patients of toxic multinodular goiter: A quality improvement project. (23599590)
2012
9
Minimal Invasive Follicular Thyroid Carcinoma Developed in Dyshormonogenetic Multinodular Goiter Due to Thyroid Peroxidase Gene Mutation. (22260524)
2012
10
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (21205968)
2011
11
Thyroid hemiagenesis with multinodular goiter: a case presentation and review of literature. (21225789)
2010
12
Tuberculosis of the thyroid presenting as multinodular goiter with hypothyroidism: a rare presentation. (20699540)
2010
13
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
14
A 30-year perspective on radioiodine therapy of benign nontoxic multinodular goiter. (19623060)
2009
15
Radioiodine therapy for multinodular goiter. (22964127)
2008
16
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
17
Predictive value of sonographic features in preoperative evaluation of malignant thyroid nodules in a multinodular goiter. (18443853)
2008
18
Bone metastasis of a follicular thyroid carcinoma originated in a toxic multinodular goiter. (19013369)
2008
19
LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter: a prospective randomized study. (17309966)
2007
20
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
21
A multinodular goiter as the initial presentation of a renal cell carcinoma harbouring a novel VHL mutation. (17067398)
2006
22
Subtotal thyroidectomy for benign multinodular goiter: a 6-month postoperative study of the remnant's function and sonographic aspect. (16736342)
2006
23
Estrogen receptor (ER)-beta, but not ER-alpha, is present in thyroid vessels: immunohistochemical evaluations in multinodular goiter and papillary thyroid carcinoma. (17199431)
2006
24
Mutations in the thyrotropin receptor signal transduction pathway in the hyperfunctioning thyroid nodules from multinodular goiters: a study in the Turkish population. (16284436)
2005
25
Total thyroidectomy for multinodular goiter in the elderly. (16105529)
2005
26
Preoperative embolization of thyroid arteries in a patient with large multinodular goiter and papillary carcinoma. (15671777)
2004
27
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
28
The influence of parity on multinodular goiter prevalence in areas with moderate iodine deficiency. (12035941)
2002
29
A somatic mutation in the thyrotropin receptor gene in a patient with an autonomous nodule within a multinodular goiter. (17018437)
2002
30
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
31
Toxic thyroid adenoma and toxic multinodular goiter. (11434717)
2001
32
Sodium/iodide symporter (NIS) and pendrin are expressed differently in hot and cold nodules of thyroid toxic multinodular goiter. (11720877)
2001
33
Postintervention serum TSH levels may be useful to differentiate patients who should undergo levothyroxine suppressive therapy after thyroid surgery for multinodular goiter in a region with moderate iodine deficiency. (11201853)
2000
34
Horner's syndrome: recovery after surgical excision of intrarhoracic benign multinodular goiter. (11200948)
2000
35
Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter. (10852462)
2000
36
Screening of thyrotropin receptor mutations by fine-needle aspiration biopsy in autonomous functioning thyroid nodules in multinodular goiters. (10319940)
1999
37
Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. (9467563)
1998
38
Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. (9345104)
1997
39
Frequency of thyroid carcinoma in a recent series of 539 consecutive thyroidectomies for multinodular goiter. (9267482)
1997
40
Reduction in goiter size by 131I therapy in patients with non-toxic multinodular goiter. (7850014)
1995
41
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
42
Levothyroxine suppressive therapy in the medical management of nontoxic benign multinodular goiter. (8299711)
1993
43
Dosimetric determination of I-131 activity in the treatment of recurrent, nontoxic, multinodular goiter. (8319402)
1993
44
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
45
Intrathyroidal lymphocytes from non toxic multinodular goiter: no evidence for production of thyroid stimulating antibodies. (1983328)
1990
46
Treatment of toxic multinodular goiter (Plummer's disease): surgery or radioiodine? (3751092)
1986
47
Circulating immunoglobulin E (IgE) antibodies to L-thyroxine in a euthyroid patient with multinodular goiter and allergic rhinitis. (6715795)
1984
48
Acute life threatening respiratory failure due to multinodular goiter. (6838062)
1983
49
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
50
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976

Genetic Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Multinodular Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.1TSHR, TPO, TG
3
Hide members
10.1TSHR, SLC26A4, GNAS
410.1ADCY10, GNAS, CALCA

Compounds for genes affiliated with Multinodular Goiter

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.6TG, TPO
2diiodotyrosine4410.5TG, TPO
3forskolin44 49 1112.5CALCA, NKX2-1, TSHR
4perchlorate4410.5TG, TPO, SLC26A4
5propylthiouracil44 2 1112.5TG, TPO, TSHR
6glutamate4410.5TPO, TRH, GNAS
7125i4410.4TSHR, TPO, TG
8estrogen4410.4TRH, TSHR, TG
9iodide44 2411.4TG, TPO, SLC26A4, NKX2-1
10dopamine44 28 11 2413.4TGFB3, TRH, GNAS
11iloprost44 59 28 1113.3ADCY10, GNAS, HSPG2
12cycloheximide4410.3HSPG2, TRH, ADCY10
13acth4410.3TPO, TSHR, TRH, GNAS
14sodium iodide4410.3NKX2-1, SLC26A4, TSHR, TPO, TG
15spec-t4410.3TG, CP, CALCA
16sialic acid4410.3GNAS, TSHR, CP, TG
17atropine44 28 1112.2HSPG2, CALCA, TRH, ADCY10
18hydrocortisone44 2 59 1113.2TG, TPO, TRH, CALCA
19triiodothyronine4410.2TRH, SLC26A4, TSHR, TPO, TG
20methimazole44 2 1112.2TG, CP, TPO, TSHR, TRH
21octreotide44 59 28 1113.2CALCA, GNAS, TRH, ADCY10, TG
22fluoride4410.2HSPG2, CALCA, ADCY10
23carbohydrates4410.1KRT19, TSHR, CP, TG
24iodine44 2411.1TG, TPO, TSHR, SLC26A4, TRH, GNAS
25guanine44 11 2412.1HSPG2, CALCA, GNAS, TSHR, ADCY10, TG
26ibmx44 28 5912.1HSPG2, CALCA, TRH, ADCY10, TGFB3
27inositol 1,4,5 trisphosphate4410.1HSPG2, TRH, TSHR, ADCY10
28gnrh4410.1HSPG2, GNAS, NKX2-1, TRH, TGFB3
29norepinephrine44 11 2412.0CALCA, GNAS, TRH, ADCY10, TG
30acetylcholine44 49 28 11 2414.0HSPG2, CALCA, TRH, ADCY10, TPO, TG
31clonidine44 28 1112.0ADCY10, TRH, CALCA
32paraffin4410.0NKX2-1, KRT19, TSHR, TG, TGFB3
33ribonucleic acid449.9GNAS, NKX2-1, KRT19, TSHR, TPO, TG
34thyroxine44 2410.9CALCA, TRH, SLC26A4, TSHR, TPO, CP
35thapsigargin44 5910.9HSPG2, TRH, ADCY10, TG
36thymidine44 2410.9GNAS, TRH, KRT19, TSHR, TG, TGFB3
37adenosine 3,5-cyclic monophosphorothioate449.9ADCY10, CALCA
38serine449.9VHL, GNAS, NKX2-1, KRT19, TSHR
39progesterone44 59 28 11 2413.9TGFB3, TSHR, KRT19, TRH, NKX2-1, GNAS
40arginine449.8GNAS, TRH, TSHR, ADCY10, TPO, CP
41oligonucleotide449.8VHL, GNAS, NKX2-1, TRH, TSHR, TPO
42glutamine449.8HSPG2, GNAS, TSHR, CP, TG
43testosterone44 59 11 2412.8CALCA, TRH, KRT19, TPO, CP, TG
44cyclic amp44 2410.7HSPG2, CALCA, GNAS, NKX2-1, TRH, TSHR
45retinoic acid44 2410.7HSPG2, NKX2-1, KRT19, TSHR, TPO, CP
46vegf449.7HSPG2, VHL, CALCA, KRT19, TSHR, CP
47dexamethasone44 49 28 1112.7HSPG2, NKX2-1, TRH, ADCY10, CP, TGFB3
48adenylate449.7HSPG2, CALCA, GNAS, TRH, TSHR, ADCY10
49tyrosine449.3HSPG2, VHL, GNAS, NKX2-1, TRH, SLC26A4
50calcium44 49 11 2412.0HSPG2, VHL, CALCA, GNAS, TRH, KRT19

GO Terms for genes affiliated with Multinodular Goiter

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16Gene Ontology
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Cellular components related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TGFB3, TG, CP, TRH, GNAS, CALCA

Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.2TG, TPO
2cAMP biosynthetic processGO:00617110.1ADCY10, GNAS
3hormone biosynthetic processGO:0424469.9TG, TPO

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.2ADCY10, GNAS

Products for genes affiliated with Multinodular Goiter

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Sources for Multinodular Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet