MCID: MLT008
MIFTS: 35

Multinodular Goiter malady

Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Multinodular Goiter

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS
See all sources

Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 10 47 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:0050489

Summaries for Multinodular Goiter

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Disease Ontology:10 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary: Multinodular Goiter is related to thyroiditis and rhabdomyosarcoma, embryonal, 2. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Endothelin and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, bone and lung, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Related Diseases for Multinodular Goiter

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Diseases in the Multinodular Goiter family:

Familial Multinodular Goiter

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.8CALCA, TG
2rhabdomyosarcoma, embryonal, 230.5DICER1, TG, TPO
3nodular goiter30.3CALCA, TG, TPO, TSHR
4thymoma30.1CALCA, NKX2-1
5cellulitis29.8CALCA, NKX2-1, TG
6thyroid gland disease29.3CALCA, NKX2-1, PAX8, SLC26A4, TG, TPO
7goiter11.4
8graves' disease10.8
9hyperthyroidism10.8
10adenoma10.7
11thyroid cancer10.7
12familial multinodular goiter10.6
13primary hyperparathyroidism10.6
14hyperparathyroidism10.6
15papillary carcinoma10.5
16parathyroid adenoma10.5
17thyroid hemiagenesis10.5
18goiter, multinodular 1, with or without sertoli-leydig cell tumors10.5
19hypothyroidism10.5
20sertoli-leydig cell tumor10.4
21leydig cell tumor10.4
22daneman davy mancer syndrome10.4
23short stature, microcephaly, and endocrine dysfunction10.3
24horner's syndrome10.3
25plummer's disease10.3
26endemic goiter10.3
27hyperthyroidism, nonautoimmune10.3GNAS, TSHR
28adult central nervous system germinoma10.3TG, TSHR
29autoimmune thyroiditis10.3TG, TPO
30thyroid ectopia10.2TG, TPO
31lumbosacral plexus lesion10.2TG, TPO
32methemoglobinemia10.2TG, TPO
33hypothryoidism, congenital, nongoitrous 410.2TG, TPO
34neurofibrosarcoma10.2TG, TPO
35lung cancer10.2
36alstrom syndrome10.2
37obesity10.2
38renal cell carcinoma10.2
39allergic rhinitis10.2
40thyroid cancer, nonmedullary, 410.2
41myasthenia gravis10.2
42pemphigus foliaceus10.2
43tracheal disease10.2
44extramedullary plasmacytoma10.2
45suppurative thyroiditis10.2
46acromegaly10.2
47hypoparathyroidism10.2
48hyperthyroxinemia10.2
49thyroid lymphoma10.2
50pemphigus10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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Drugs & Therapeutics for Multinodular Goiter

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Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1CoagulantsPhase 2, Phase 3983
2
Iodine4597553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
3cadexomer iodine425

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1The Role of Levothyroxine on Goiter With Atypia of Undetermined SignificanceNot yet recruitingNCT02329379Phase 4
2Clinical Trial on Harmonic Focus ShearsCompletedNCT01003652Phase 2, Phase 3
3Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular GoiterCompletedNCT00454220Phase 2
4rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
5rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
6Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating HormoneCompletedNCT00137891Phase 1
7Three-Year Follow-up of Radioiodine Therapy for GoitreCompletedNCT00509483
8Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft FunctionCompletedNCT02194920
9A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid SurgeryCompletedNCT01163565
10Swallowing Function Before and After Surgery for Thyroid GoiterCompletedNCT00205348
11Thyroid Lobectomy With or Without Levothyroxine Treatment PostoperativelyCompletedNCT00941551
12Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid DiseaseCompletedNCT00666315
13Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid NodulesCompletedNCT00571090
14Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
15Budget Impact of Harmonic FOCUS in ThyroidectomyActive, not recruitingNCT01658085
16Galectin 3 Dosage in Diagnosis of Nodular and Multinodular GoiterActive, not recruitingNCT01588288
17Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid CancerWithdrawnNCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

33
Thyroid, Bone, Lung, Colon, Pituitary, Trachea, Endothelial

Animal Models for Multinodular Goiter or affiliated genes

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MGI Mouse Phenotypes related to Multinodular Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5CALCA, DICER1, GNAS, PAX8, SLC26A4
2MP:00053778.5CALCA, GNAS, PAX8, SLC26A4, TPO, TSHR
3MP:00053907.8CALCA, DICER1, GNAS, NKX2-1, PAX8, SLC26A4
4MP:00053787.8DICER1, GNAS, NKX2-1, PAX8, TG, TPO
5MP:00053867.3CALCA, CP, DICER1, GNAS, NKX2-1, SLC26A4
6MP:00053797.3DICER1, GNAS, NKX2-1, PAX8, SLC26A4, TG
7MP:00053857.0CALCA, CP, DICER1, GNAS, GSR, NKX2-1
8MP:00036316.2CALCA, CP, DICER1, GNAS, NKX2-1, PAX8
9MP:00053765.7CALCA, CP, DICER1, GNAS, NKX2-1, PAX8

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. (26319784)
2015
2
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. (25981745)
2015
3
Congenital thyroid hemiagenesis with multinodular goiter. (25379177)
2014
4
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. (25189867)
2014
5
Adenomatous multinodular goiter causing airway obstruction in an infant. (24622964)
2014
6
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
7
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
8
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
9
The predictive value of dominant nodules and the management of indeterminate group in multinodular goiter. (21479880)
2012
10
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
11
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
12
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
13
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
14
Radioiodine therapy for multinodular goiter. (22964127)
2008
15
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
16
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
17
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
18
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
19
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
20
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
21
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
22
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
23
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
24
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
25
Diagnosis of multinodular goiter by endoscopic ultrasound-guided fine-needle aspiration. (17366423)
2006
26
Multinodular goiter. (12803008)
2003
27
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
28
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
29
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
30
Multinodular Goiter (25905424)
2000
31
Multinodular goiter: the surgical procedure of choice. (10828797)
2000
32
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
33
Total thyroidectomy for multinodular goiter. (9851343)
1998
34
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
35
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
36
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
37
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
38
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
39
Immunological features of sporadic multinodular goiter. (8374249)
1993
40
Association of multinodular goiter with breast carcinoma: Cowden's disease. (8144869)
1993
41
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
42
Treatment of non-toxic multinodular goiter with radioactive iodine. (3337130)
1988
43
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
46
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
47
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
48
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
49
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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Pathways related to Multinodular Goiter according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CALCA, GNAS
29.6TG, TPO, TSHR
39.4CALCA, GNAS, TSHR
49.0GNAS, NKX2-1, PAX8
5
Show member pathways
7.2GNAS, GSR, NKX2-1, PAX8, SLC26A4, TG

GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1iodide transportGO:001570510.4SLC26A4, TG
2inner ear receptor cell developmentGO:006011910.1DICER1, TSHR
3thyroid-stimulating hormone signaling pathwayGO:003819410.1PAX8, TSHR
4regulation of myelinationGO:003164110.0DICER1, TG
5embryonic hindlimb morphogenesisGO:00351169.9DICER1, GNAS
6hormone biosynthetic processGO:00424469.9TG, TPO
7positive regulation of cAMP biosynthetic processGO:00308199.7CALCA, GNAS
8feeding behaviorGO:00076319.7CALCA, NKX2-1
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.6CALCA, GNAS, TSHR
10activation of adenylate cyclase activityGO:00071909.6CALCA, GNAS, TSHR
11thyroid gland developmentGO:00308788.7NKX2-1, PAX8, TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00049969.6PAX8, TSHR

Sources for Multinodular Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet