MCID: MLT008
MIFTS: 41

Multinodular Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

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Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 11 27 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:0050489

Summaries for Multinodular Goiter

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Disease Ontology:11 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary: Multinodular Goiter is related to nodular goiter and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Endothelin and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, bone and trachea, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Related Diseases for Multinodular Goiter

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Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1nodular goiter29.6CALCA, TG, TPO
2goiter, multinodular 1, with or without sertoli-leydig cell tumors11.8
3graves' disease11.4
4short stature, microcephaly, and endocrine dysfunction11.2
5daneman davy mancer syndrome11.2
6thyroid cancer, nonmedullary, 411.0
7myopathy - thyrotoxic11.0
8goiter, multinodular, cystic renal disease, and digital anomalies11.0
9cln4 disease11.0
10goiter11.0
11thyroiditis10.7
12hyperthyroidism, nonautoimmune10.5GNAS, TSHR
13iatrogenic or traumatic pituitary deficiency10.5TG, TPO
14ovarian endometrioid cystadenoma10.5TG, TPO
15peripheral scars of retina10.4TG, TPO
16presbyopia10.4TG, TSHR
17chronic frontal sinusitis10.4TG, TPO
18transient hypogammaglobulinemia of infancy10.3NKX2-1, TG
19adenoma10.3
20hyperthyroidism10.3
21hypothryoidism, congenital, nongoitrous 410.3TG, TPO
22adult teratoma10.3NKX2-1, TG
23thyroid cancer10.3
24tinea corporis10.2SLC26A4, TG
25glaucomatocyclitic crisis10.2TG, TSHR
26hypertelorism, preauricular sinus, punctal pits, and deafness10.2TG, TPO, TSHR
27cd3zeta deficiency10.2TG, TPO, TSHR
28blood group incompatibility10.2TG, TPO, TSHR
29uterine ligament serous adenocarcinoma10.2GNAS, HRAS
30deep angioma10.2CALCA, TG
31intermittent proptosis10.2TG, TPO, TSHR
32acute thyroiditis10.2CALCA, TG
33retinitis pigmentosa 2710.2HRAS, NKX2-1
34pleomorphic adenoma10.2CALCA, TG
35bone remodeling disease10.2DICER1, NKX2-1
36classic pulmonary blastoma10.2DICER1, NKX2-1
37mixed endometrial stromal and smooth muscle tumor10.2CALCA, TG
38norwegian scabies10.2CALCA, TG
39hyperparathyroidism10.1
40parathyroid adenoma10.1
41hypocomplementemic urticarial vasculitis syndrome10.1CALCA, TG
42rhabdomyosarcoma, embryonal, 210.1DICER1, TG, TPO
43cerebral lipidosis10.1CALCA, TG
44trachea adenoid cystic carcinoma10.1HRAS, NKX2-1
45malignant syringoma10.1NKX2-1, TG, TSHR
46benign mesothelioma10.1NKX2-1, TG, TSHR
47dysautonomia, familial10.1TG, TPO
48papillary carcinoma10.1
49bone lymphoma10.1CALCA, TG
50demyelinating polyneuropathy10.1HRAS, TG, TSHR

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms & Phenotypes for Multinodular Goiter

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MGI Mouse Phenotypes related to Multinodular Goiter according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4GNAS, PAX8, SLC26A4, TPO, TSHR
2MP:00053719.3DICER1, GNAS, PAX8, TPO, TSHR
3MP:00053678.6DICER1, GNAS, HRAS, PAX8, SLC26A4
4MP:00053828.6DICER1, GNAS, HRAS, PAX8, XRCC4
5MP:00030128.5DICER1, GNAS, HRAS, NKX2-1, PAX8
6MP:00053898.4DICER1, NKX2-1, PAX8, SLC26A4, TSHR, XRCC4
7MP:00020068.3DICER1, GNAS, HRAS, NKX2-1, TSHR, XRCC4
8MP:00053787.1DICER1, GNAS, HRAS, NKX2-1, PAX8, TG
9MP:00036317.0DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
10MP:00053796.8DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
11MP:00053766.7DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
12MP:00053906.2DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4

Drugs & Therapeutics for Multinodular Goiter

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Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AutoantibodiesPhase 4126
2HemostaticsPhase 2, Phase 31359
3CoagulantsPhase 2, Phase 31428
4
Salmon Calcitoninapproved, investigationalPhase 29147931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin salmon recombinant
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
5calcitoninPhase 2103
6Calcitonin Gene-Related PeptidePhase 291
7HormonesPhase 2, Phase 113979
8Bone Density Conservation AgentsPhase 23266
9Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 112767
10Hormone AntagonistsPhase 112778
11Anesthetics9001
12cadexomer iodine514
13
Iodine5467553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1The Role of Levothyroxine on Goiter With Atypia of Undetermined SignificanceNot yet recruitingNCT02329379Phase 4
2Clinical Trial on Harmonic Focus ShearsCompletedNCT01003652Phase 2, Phase 3
3Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular GoiterCompletedNCT00454220Phase 2
4rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
5rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
6Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating HormoneCompletedNCT00137891Phase 1
7Budget Impact of Harmonic FOCUS in ThyroidectomyUnknown statusNCT01658085
8Three-Year Follow-up of Radioiodine Therapy for GoitreCompletedNCT00509483
9Galectin 3 Dosage in Diagnosis of Nodular and Multinodular GoiterCompletedNCT01588288
10Swallowing Function Before and After Surgery for Thyroid GoiterCompletedNCT00205348
11Thyroid Lobectomy With or Without Levothyroxine Treatment PostoperativelyCompletedNCT00941551
12Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid DiseaseCompletedNCT00666315
13A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid SurgeryCompletedNCT01163565
14Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft FunctionCompletedNCT02194920
15Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid NodulesCompletedNCT00571090
16Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
17Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid CancerWithdrawnNCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Genetic tests related to Multinodular Goiter:

id Genetic test Affiliating Genes
1 Multinodular Goiter27

Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

36
Thyroid, Bone, Trachea, Pituitary, Lung, Colon, Heart

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 313)
idTitleAuthorsYear
1
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. (26817871)
2016
2
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. (27459524)
2016
3
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? (27525921)
2016
4
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). (28078873)
2016
5
Multinodular goiter with adipose metaplasia: A case report. (27772959)
2016
6
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. (26985161)
2016
7
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? (27428220)
2016
8
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. (27055746)
2016
9
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. (26708850)
2016
10
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. (26982637)
2016
11
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. (27029843)
2016
12
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. (26871832)
2016
13
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? (28005977)
2016
14
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. (26884295)
2016
15
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. (28025831)
2016
16
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. (27703446)
2016
17
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. (28031674)
2016
18
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. (27988915)
2016
19
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. (26841373)
2016
20
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. (27480576)
2016
21
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. (26319784)
2015
22
Large multinodular goiter--outpatient radioiodine treatment. (26323466)
2015
23
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? (25594634)
2015
24
The Natural History of Multinodular Goiter. (26364072)
2015
25
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. (25981745)
2015
26
Thyroid storm associated with multinodular goiter: a difficult problem to treat. (25772969)
2015
27
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. (27011525)
2015
28
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? (26702247)
2015
29
Congenital thyroid hemiagenesis with multinodular goiter. (25379177)
2014
30
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. (25189867)
2014
31
Adenomatous multinodular goiter causing airway obstruction in an infant. (24622964)
2014
32
Multinodular goiter with retrosternal extension causing airway obstruction: Management in intensive care unit and operating room. (25136197)
2014
33
Bone Marrow Metaplasia in Multinodular Goiter With Primary Hyperparathyroidism. (25310511)
2014
34
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter. (25451712)
2014
35
Multinodular Goiter in children: an important pointer to a germline DICER1 mutation. (24628552)
2014
36
Trigeminal autonomic headaches caused by a multinodular goiter--a case report. (24628230)
2014
37
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. (24708902)
2014
38
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. (24555692)
2014
39
Toxic multinodular goiter in a patient with end-stage renal disease and hemodialysis. (25089233)
2014
40
Anaplastic carcinoma and toxic multinodular goiter: an unusual presentation. (25759806)
2014
41
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
42
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
43
Experience with total thyroidectomy for massive multinodular goiter. (23896257)
2013
44
Total Thyroidectomy for Multinodular Goiter. Possibility of Implementation in aA District Hospital. (23585205)
2013
45
A Novel, Homozygous c.1502T>G (p.Val501Gly) Mutation in the Thyroid peroxidase Gene in Malaysian Sisters with Congenital Hypothyroidism and Multinodular Goiter. (23737781)
2013
46
The association between development and progression of multinodular goiter and thyroid-stimulating hormone receptor gene D727E and P52T polymorphisms. (23336574)
2013
47
Unilateral thyroidectomy for the treatment of benign multinodular goiter. (23688788)
2013
48
Artificial neural network analysis for evaluating cancer risk in multinodular goiter. (24516485)
2013
49
Long-term efficacy of modified-release recombinant human TSH (MRrhTSH) augmented radioiodine (131I) therapy for benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled dose-selection study. (24341527)
2013
50
Toxic multinodular goiter: an unusual cause of pleural effusion. (23609264)
2013

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:000719010.3CALCA, TSHR
2hormone biosynthetic processGO:004244610.3TG, TPO
3iodide transportGO:001570510.2SLC26A4, TG
4feeding behaviorGO:000763110.0CALCA, NKX2-1
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:000718910.0CALCA, GNAS, TSHR
6thyroid hormone generationGO:00065909.8TG, TPO
7thyroid-stimulating hormone signaling pathwayGO:00381949.6PAX8, TSHR
8thyroid gland developmentGO:00308789.3NKX2-1, PAX8, TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00049969.6PAX8, TSHR

Sources for Multinodular Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet