MCID: MLT008
MIFTS: 48

Multinodular Goiter malady

Endocrine diseases category
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Summaries for Multinodular Goiter

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Wikipedia:65 A multinodular goiter is a multinodular enlargement of the thyroid gland. more...

MalaCards based summary: Multinodular Goiter is related to graves' disease and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Adenylate cyclase activating neuropeptides and Endothelin. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are behavior/neurological and hematopoietic system.

Disease Ontology:8 A goiter characterized by a multinodular enlargement of the thyroid gland.

Descriptions from OMIM:46 300273,606082,138800

Aliases & Classifications for Multinodular Goiter

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 46OMIM
See all sources

Multinodular Goiter, Aliases & Descriptions:

Name: Multinodular Goiter 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:0050489

Related Diseases for Multinodular Goiter

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Diseases in the Multinodular Goiter family:

Goiter, Multinodular, 3 Goiter, Multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease31.5GNAS, TSHR
2thyroiditis31.4TPO, TG, TSHR, CALCA
3parathyroid adenoma31.0GNAS, CALCA
4goiter30.9GNAS, TPO, TG, TSHR, CALCA, SLC26A4
5thyrotoxicosis30.8TPO, TG, TSHR
6papillary thyroid carcinoma30.8TSHR, TG, TPO
7hyperthyroidism30.7GNAS, TPO, TG, TSHR
8plummer's disease30.7TPO, TG
9hyperthyroxinemia30.6TPO, TSHR
10follicular thyroid carcinoma30.6CALCA, TSHR, TG
11endemic goiter30.5TPO, TG, TSHR
12thyroid adenoma30.3GNAS, TPO, TG, TSHR
13hypothyroidism30.0TPO, TG, TSHR, SLC26A4
14nodular goiter29.9TPO, TG, TSHR, CALCA
15congenital hypothyroidism29.9GNAS, TPO, TG, TSHR
16adenoma29.9GNAS, TPO, TG, TSHR, CALCA, SLC26A4
17papillary carcinoma29.6CALCA, SLC26A4, TSHR, TG, TPO, GNAS
18follicular adenoma29.1GNAS, TPO, TG, TSHR, CALCA, SLC26A4
19thyroid cancer10.7
20primary hyperparathyroidism10.6
21hyperparathyroidism10.6
22daneman davy mancer syndrome10.5
23sertoli-leydig cell tumor10.4
24leydig cell tumor10.4
25goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
26osteitis fibrosa10.4GNAS
27cherubism10.4CALCA
28horner's syndrome10.3
29enlarged vestibular aqueduct10.3SLC26A4
30thyroid agenesis10.2TSHR, TG
31precocious puberty10.2TSHR, GNAS
32struma ovarii10.2TSHR, TG
33myasthenia gravis10.2
34obesity10.2
35pemphigus foliaceus10.2
36renal cell carcinoma10.2
37acromegaly10.2
38suppurative thyroiditis10.2
39mccune albright syndrome10.2
40pemphigus10.2
41thyroid lymphoma10.2
42allergic rhinitis10.2
43renal clear cell carcinoma10.2
44fibrous dysplasia10.2
45alveolar rhabdomyosarcoma10.2
46hypoparathyroidism10.2
47extramedullary plasmacytoma10.2
48cellulitis10.2
49cervicitis10.2
50colon cancer10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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Clinical features from OMIM:

300273,606082,138800

Drugs & Therapeutics for Multinodular Goiter

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Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

32
Thyroid, Bone, Colon, Trachea, Pituitary, Bone marrow, Lymph node, Heart, Lung, Salivary gland, Breast, T cells, Endothelial

Animal Models for Multinodular Goiter or affiliated genes

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MGI Mouse Phenotypes related to Multinodular Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2SLC26A4, CALCA, TSHR, GNAS
2MP:00053978.2GNAS, TPO, TG, TSHR
3MP:00053908.1SLC26A4, CALCA, TPO, GNAS
4MP:00053777.9SLC26A4, CALCA, TSHR, TPO, GNAS
5MP:00053797.7GNAS, TPO, TG, TSHR, SLC26A4
6MP:00036317.6GNAS, TG, TSHR, CALCA, SLC26A4
7MP:00053767.2GNAS, TPO, TG, TSHR, CALCA, SLC26A4

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Congenital thyroid hemiagenesis with multinodular goiter. (25379177)
2014
2
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. (25189867)
2014
3
Adenomatous multinodular goiter causing airway obstruction in an infant. (24622964)
2014
4
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
5
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
6
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
7
The predictive value of dominant nodules and the management of indeterminate group in multinodular goiter. (21479880)
2012
8
Myasthenia gravis associated with thymoma and toxic multinodular goiter. A case report. (23077950)
2012
9
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
10
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
11
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
12
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
13
Radioiodine therapy for multinodular goiter. (22964127)
2008
14
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
15
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
16
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
17
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
18
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
19
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
20
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
21
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
22
H-RAS gene expression in human multinodular goiter. (17290351)
2007
23
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
24
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
25
Diagnosis of multinodular goiter by endoscopic ultrasound-guided fine-needle aspiration. (17366423)
2006
26
Multinodular goiter. (12803008)
2003
27
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
28
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
29
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
30
Multinodular goiter: the surgical procedure of choice. (10828797)
2000
31
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
32
Radioiodine treatment for nontoxic multinodular goiter. (10450683)
1999
33
Total thyroidectomy for multinodular goiter. (9851343)
1998
34
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
35
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
36
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
37
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
38
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
39
Immunological features of sporadic multinodular goiter. (8374249)
1993
40
Association of multinodular goiter with breast carcinoma: Cowden's disease. (8144869)
1993
41
Repetitive monomorphic ventricular tachycardia in a 4-year-old boy with toxic multinodular goiter. (1714224)
1991
42
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
43
Treatment of non-toxic multinodular goiter with radioactive iodine. (3337130)
1988
44
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
45
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
46
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
47
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
48
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
49
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
50
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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Compounds for genes affiliated with Multinodular Goiter

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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1carbimazole44 1111.0TSHR, TPO
2amino acid4410.0TPO, TSHR
3maltose44 1110.9TPO, TSHR
4iodotyrosine44 2410.8TG, TPO
5diiodotyrosine449.8TPO, TG
6gliadin449.7TG, TPO
7chromium449.7TPO, TG
8111in-pentetreotide449.7CALCA, TG
9deoxyribonucleic acid449.7GNAS, TSHR
10amiodarone44 50 28 1112.7TPO, TG
11cardiolipin44 1110.6TG, TPO
12spec-t449.6CALCA, TG
13asparagine449.5TSHR, TPO, GNAS
14propylthiouracil44 2 1111.4TPO, TG, TSHR
15125i449.4TSHR, TG, TPO
16methimazole44 2 1111.4TSHR, TG, TPO
17selenium44 2410.4TPO, TG
18histidine449.4TSHR, TPO, GNAS
19sialic acid449.3GNAS, TG, TSHR
20hydrocortisone44 2 61 1112.3TPO, TG, CALCA
21octreotide44 61 28 1112.2CALCA, TG, GNAS
22acetylcholine44 50 28 24 1113.2CALCA, TG, TPO
23glutamine449.1GNAS, TG, TSHR
24thymidine44 2410.1TSHR, TG, GNAS
25norepinephrine44 24 1111.1GNAS, TG, CALCA
26aspartate449.1TSHR, TG, TPO
27oligonucleotide449.1TSHR, TPO, GNAS
28cyclic amp44 2410.1GNAS, TSHR, CALCA
29creatinine449.1CALCA, TG, TPO
30chloride449.0SLC26A4, TPO, GNAS
31perchlorate449.0TPO, TG, SLC26A4
32acth449.0CALCA, TSHR, TPO, GNAS
33forskolin44 50 1111.0GNAS, TPO, TSHR, CALCA
34ribonucleic acid448.9GNAS, TPO, TG, TSHR
35polysaccharide448.9GNAS, TPO, TG, TSHR
36guanine44 24 1110.8GNAS, TG, TSHR, CALCA
37arginine448.8TSHR, TG, TPO, GNAS
38cysteine448.8GNAS, TPO, TG, TSHR
39sodium iodide448.6TPO, TG, TSHR, SLC26A4
40iodide44 249.6SLC26A4, TSHR, TG, TPO
41triiodothyronine448.6SLC26A4, TSHR, TG, TPO
42testosterone44 61 24 1111.6CALCA, TG, TPO
43sodium44 249.6TPO, TG, TSHR, SLC26A4
44nitric oxide44 24 1110.5GNAS, TPO, CALCA, SLC26A4
45h2o2448.5TPO, TG, SLC26A4
46adenylate448.4GNAS, TPO, TG, TSHR, CALCA
47glutamate448.4GNAS, TPO, TG, TSHR, CALCA
48iodine44 249.1SLC26A4, TSHR, TG, TPO, GNAS
49thyroxine44 249.1TPO, TG, TSHR, CALCA, SLC26A4
50tyrosine448.0GNAS, TPO, TG, TSHR, SLC26A4

GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TPO, TG
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.4GNAS, CALCA
3thyroid hormone generationGO:0065909.4TG, TPO
4activation of adenylate cyclase activityGO:0071909.3CALCA, GNAS
5positive regulation of cAMP biosynthetic processGO:0308199.1CALCA, GNAS

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3CALCA, TG

Products for genes affiliated with Multinodular Goiter

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  • Antibodies
  • Proteins
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Sources for Multinodular Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet