MCID: MLT008
MIFTS: 45

Multinodular Goiter malady

Endocrine diseases category
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Summaries for Multinodular Goiter

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A multinodular goiter is a multinodular enlargement of the thyroid gland. more...

MalaCards: Multinodular Goiter is related to goiter and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Adenylate cyclase activating neuropeptides and Endothelin. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and trachea, and related mouse phenotypes are behavior/neurological and hematopoietic system.

Description from OMIM:47 138800

Aliases & Classifications for Multinodular Goiter

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8Disease Ontology, 45Novoseek, 62UMLS, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

multinodular goiter 8 45 62


External Ids:

Disease Ontology8 DOID:0050489
OMIM47 138800

Related Diseases for Multinodular Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Multinodular Goiter family:

Goiter, Multinodular, 3 Goiter, Multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.8GNAS, TPO, TG, TSHR, CALCA, SLC26A4
2thyroiditis31.6TPO, TG, TSHR, CALCA
3graves' disease31.2GNAS, TSHR
4hyperthyroidism30.9GNAS, TPO, TG, TSHR
5thyrotoxicosis30.8TPO, TG, TSHR
6papillary thyroid carcinoma30.8TSHR, TG, TPO
7parathyroid adenoma30.8GNAS, CALCA
8adenoma30.7GNAS, TPO, TG, TSHR, CALCA, SLC26A4
9thyroid cancer30.7GNAS, TPO, TG, TSHR, CALCA, SLC26A4
10follicular thyroid carcinoma30.6CALCA, TSHR, TG
11plummer's disease30.5TPO, TG
12thyroid adenoma30.5GNAS, TPO, TG, TSHR
13papillary carcinoma30.5CALCA, SLC26A4, TSHR, TG, TPO, GNAS
14endemic goiter30.5TPO, TG, TSHR
15hypothyroidism30.3TPO, TG, TSHR, SLC26A4
16hyperthyroxinemia30.3TPO, TSHR
17nodular goiter30.2TPO, TG, TSHR, CALCA
18congenital hypothyroidism30.2GNAS, TPO, TG, TSHR
19primary hyperparathyroidism10.5
20hyperparathyroidism10.5
21daneman davy mancer syndrome10.5
22goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
23sertoli-leydig cell tumor10.3
24horner's syndrome10.3
25leydig cell tumor10.3
26mccune albright syndrome10.2
27pemphigus10.2
28acromegaly10.2
29alveolar rhabdomyosarcoma10.2
30thyroid lymphoma10.2
31allergic rhinitis10.2
32renal clear cell carcinoma10.2
33hypoparathyroidism10.2
34extramedullary plasmacytoma10.2
35fibrous dysplasia10.2
36suppurative thyroiditis10.2
37cellulitis10.2
38cervicitis10.2
39colon cancer10.2
40laryngitis10.2
41lung cancer10.2
42melanoma10.2
43myasthenia gravis10.2
44obesity10.2
45plasmacytoma10.2
46renal cell carcinoma10.2
47respiratory failure10.2
48rhabdomyosarcoma10.2
49rhinitis10.2
50sarcoidosis10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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47OMIM
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Clinical features from OMIM:

138800

Drugs & Therapeutics for Multinodular Goiter

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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33MalaCards
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MalaCards organs/tissues related to Multinodular Goiter:

33
Thyroid, Bone, Trachea, Pituitary, Colon, Lung, Heart, Breast, T cells, Endothelial, Lymph node, Salivary gland

Animal Models for Multinodular Goiter or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Multinodular Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2SLC26A4, CALCA, TSHR, GNAS
2MP:00053978.2GNAS, TPO, TG, TSHR
3MP:00053908.1SLC26A4, CALCA, TPO, GNAS
4MP:00053777.9SLC26A4, CALCA, TSHR, TPO, GNAS
5MP:00053797.7GNAS, TPO, TG, TSHR, SLC26A4
6MP:00036317.6GNAS, TG, TSHR, CALCA, SLC26A4
7MP:00053767.2GNAS, TPO, TG, TSHR, CALCA, SLC26A4

Publications for Multinodular Goiter

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52PubMed
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Articles related to Multinodular Goiter:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
2
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
3
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
4
The predictive value of dominant nodules and the management of indeterminate group in multinodular goiter. (21479880)
2012
5
Myasthenia gravis associated with thymoma and toxic multinodular goiter. A case report. (23077950)
2012
6
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
7
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
8
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
9
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
10
Anaplastic thyroid carcinoma arising in long-standing multinodular goiter following radioactive iodine therapy: report of a case diagnosed by fine needle aspiration. (19798888)
2009
11
Radioiodine therapy for multinodular goiter. (22964127)
2008
12
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
13
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
14
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
15
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
16
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
17
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
18
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
19
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
20
H-RAS gene expression in human multinodular goiter. (17290351)
2007
21
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
22
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
23
Diagnosis of multinodular goiter by endoscopic ultrasound-guided fine-needle aspiration. (17366423)
2006
24
Multinodular goiter. (12803008)
2003
25
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
26
Pemberton's sign associated with a large multinodular goiter. (12804111)
2003
27
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
28
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
29
Multinodular goiter: the surgical procedure of choice. (10828797)
2000
30
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
31
Radioiodine treatment for nontoxic multinodular goiter. (10450683)
1999
32
Total thyroidectomy for multinodular goiter. (9851343)
1998
33
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
34
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
35
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
36
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
37
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
38
Immunological features of sporadic multinodular goiter. (8374249)
1993
39
Association of multinodular goiter with breast carcinoma: Cowden's disease. (8144869)
1993
40
Repetitive monomorphic ventricular tachycardia in a 4-year-old boy with toxic multinodular goiter. (1714224)
1991
41
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
42
Treatment of non-toxic multinodular goiter with radioactive iodine. (3337130)
1988
43
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
46
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
47
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
48
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
49
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Multinodular Goiter

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1carbimazole45 1111.0TSHR, TPO
2amino acid4510.0TPO, TSHR
3maltose45 1110.9TPO, TSHR
4iodotyrosine45 2410.8TG, TPO
5diiodotyrosine459.8TPO, TG
6gliadin459.7TG, TPO
7chromium459.7TPO, TG
8111in-pentetreotide459.7CALCA, TG
9deoxyribonucleic acid459.7GNAS, TSHR
10amiodarone45 51 29 1112.7TPO, TG
11cardiolipin45 1110.6TG, TPO
12spec-t459.6CALCA, TG
13asparagine459.5TSHR, TPO, GNAS
14propylthiouracil45 3 1111.4TPO, TG, TSHR
15125i459.4TSHR, TG, TPO
16methimazole45 3 1111.4TSHR, TG, TPO
17selenium45 2410.4TPO, TG
18histidine459.4TSHR, TPO, GNAS
19sialic acid459.3GNAS, TG, TSHR
20hydrocortisone45 3 61 1112.3TPO, TG, CALCA
21octreotide45 61 29 1112.2CALCA, TG, GNAS
22acetylcholine45 51 29 24 1113.2CALCA, TG, TPO
23glutamine459.1GNAS, TG, TSHR
24thymidine45 2410.1TSHR, TG, GNAS
25norepinephrine45 24 1111.1GNAS, TG, CALCA
26aspartate459.1TSHR, TG, TPO
27oligonucleotide459.1TSHR, TPO, GNAS
28cyclic amp45 2410.1GNAS, TSHR, CALCA
29creatinine459.1CALCA, TG, TPO
30chloride459.0SLC26A4, TPO, GNAS
31perchlorate459.0TPO, TG, SLC26A4
32acth459.0CALCA, TSHR, TPO, GNAS
33forskolin45 51 1111.0GNAS, TPO, TSHR, CALCA
34ribonucleic acid458.9GNAS, TPO, TG, TSHR
35polysaccharide458.9GNAS, TPO, TG, TSHR
36guanine45 24 1110.8GNAS, TG, TSHR, CALCA
37arginine458.8TSHR, TG, TPO, GNAS
38cysteine458.8GNAS, TPO, TG, TSHR
39sodium iodide458.6TPO, TG, TSHR, SLC26A4
40iodide45 249.6SLC26A4, TSHR, TG, TPO
41triiodothyronine458.6SLC26A4, TSHR, TG, TPO
42testosterone45 61 24 1111.6CALCA, TG, TPO
43sodium45 249.6TPO, TG, TSHR, SLC26A4
44nitric oxide45 24 1110.5GNAS, TPO, CALCA, SLC26A4
45h2o2458.5TPO, TG, SLC26A4
46adenylate458.4GNAS, TPO, TG, TSHR, CALCA
47glutamate458.4GNAS, TPO, TG, TSHR, CALCA
48iodine45 249.1SLC26A4, TSHR, TG, TPO, GNAS
49thyroxine45 249.1TPO, TG, TSHR, CALCA, SLC26A4
50tyrosine458.0GNAS, TPO, TG, TSHR, SLC26A4

GO Terms for genes affiliated with Multinodular Goiter

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16Gene Ontology
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Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.4CALCA, GNAS
3thyroid hormone generationGO:0065909.4TG, TPO
4activation of adenylate cyclase activityGO:0071909.3GNAS, CALCA
5positive regulation of cAMP biosynthetic processGO:0308199.1CALCA, GNAS

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3CALCA, TG

Products for genes affiliated with Multinodular Goiter

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Sources for Multinodular Goiter

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet