MCID: MLT008
MIFTS: 45

Multinodular Goiter malady

Endocrine diseases category

Summaries for Multinodular Goiter

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 A multinodular goiter is a multinodular enlargement of the thyroid gland. more...

MalaCards: Multinodular Goiter is related to goiter and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Adenylate cyclase activating neuropeptides and Endothelin. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and trachea, and related mouse phenotypes are behavior/neurological and hematopoietic system.

Description from OMIM:48 138800

Aliases & Classifications for Multinodular Goiter

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9Disease Ontology, 46Novoseek, 63UMLS, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

multinodular goiter 9 46 63


External Ids:

Disease Ontology9 DOID:0050489
OMIM48 138800

Related Diseases for Multinodular Goiter

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Multinodular Goiter family:

Goiter, Multinodular, 3 Goiter, Multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.8GNAS, TPO, TG, TSHR, CALCA, SLC26A4
2thyroiditis31.6TPO, TG, TSHR, CALCA
3graves' disease31.2GNAS, TSHR
4hyperthyroidism30.9GNAS, TPO, TG, TSHR
5thyrotoxicosis30.8TPO, TG, TSHR
6papillary thyroid carcinoma30.8TSHR, TG, TPO
7parathyroid adenoma30.8GNAS, CALCA
8adenoma30.7GNAS, TPO, TG, TSHR, CALCA, SLC26A4
9thyroid cancer30.7GNAS, TPO, TG, TSHR, CALCA, SLC26A4
10follicular thyroid carcinoma30.6CALCA, TSHR, TG
11plummer's disease30.5TPO, TG
12thyroid adenoma30.5GNAS, TPO, TG, TSHR
13papillary carcinoma30.5CALCA, SLC26A4, TSHR, TG, TPO, GNAS
14endemic goiter30.5TPO, TG, TSHR
15hypothyroidism30.3TPO, TG, TSHR, SLC26A4
16hyperthyroxinemia30.3TPO, TSHR
17nodular goiter30.2TPO, TG, TSHR, CALCA
18congenital hypothyroidism30.2GNAS, TPO, TG, TSHR
19primary hyperparathyroidism10.5
20hyperparathyroidism10.5
21daneman davy mancer syndrome10.5
22goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
23sertoli-leydig cell tumor10.3
24horner's syndrome10.3
25leydig cell tumor10.3
26mccune albright syndrome10.2
27pemphigus10.2
28acromegaly10.2
29alveolar rhabdomyosarcoma10.2
30thyroid lymphoma10.2
31allergic rhinitis10.2
32renal clear cell carcinoma10.2
33hypoparathyroidism10.2
34extramedullary plasmacytoma10.2
35fibrous dysplasia10.2
36suppurative thyroiditis10.2
37cellulitis10.2
38cervicitis10.2
39colon cancer10.2
40laryngitis10.2
41lung cancer10.2
42melanoma10.2
43myasthenia gravis10.2
44obesity10.2
45plasmacytoma10.2
46renal cell carcinoma10.2
47respiratory failure10.2
48rhabdomyosarcoma10.2
49rhinitis10.2
50sarcoidosis10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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48OMIM
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Clinical features from OMIM:

138800

Drugs & Therapeutics for Multinodular Goiter

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Multinodular Goiter

Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Search CenterWatch for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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34MalaCards
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MalaCards organs/tissues related to Multinodular Goiter:

34
Thyroid, Bone, Trachea, Pituitary, Colon, Lung, Heart, Breast, T cells, Endothelial, Lymph node, Salivary gland

Animal Models for Multinodular Goiter or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Multinodular Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2SLC26A4, CALCA, TSHR, GNAS
2MP:00053978.2GNAS, TPO, TG, TSHR
3MP:00053908.1SLC26A4, CALCA, TPO, GNAS
4MP:00053777.9SLC26A4, CALCA, TSHR, TPO, GNAS
5MP:00053797.7GNAS, TPO, TG, TSHR, SLC26A4
6MP:00036317.6GNAS, TG, TSHR, CALCA, SLC26A4
7MP:00053767.2GNAS, TPO, TG, TSHR, CALCA, SLC26A4

Publications for Multinodular Goiter

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53PubMed
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Articles related to Multinodular Goiter:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
2
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
3
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
4
The predictive value of dominant nodules and the management of indeterminate group in multinodular goiter. (21479880)
2012
5
Myasthenia gravis associated with thymoma and toxic multinodular goiter. A case report. (23077950)
2012
6
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
7
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
8
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
9
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
10
Anaplastic thyroid carcinoma arising in long-standing multinodular goiter following radioactive iodine therapy: report of a case diagnosed by fine needle aspiration. (19798888)
2009
11
Radioiodine therapy for multinodular goiter. (22964127)
2008
12
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
13
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
14
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
15
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
16
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
17
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
18
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
19
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
20
H-RAS gene expression in human multinodular goiter. (17290351)
2007
21
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
22
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
23
Diagnosis of multinodular goiter by endoscopic ultrasound-guided fine-needle aspiration. (17366423)
2006
24
Multinodular goiter. (12803008)
2003
25
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
26
Pemberton's sign associated with a large multinodular goiter. (12804111)
2003
27
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
28
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
29
Multinodular goiter: the surgical procedure of choice. (10828797)
2000
30
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
31
Radioiodine treatment for nontoxic multinodular goiter. (10450683)
1999
32
Total thyroidectomy for multinodular goiter. (9851343)
1998
33
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
34
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
35
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
36
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
37
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
38
Immunological features of sporadic multinodular goiter. (8374249)
1993
39
Association of multinodular goiter with breast carcinoma: Cowden's disease. (8144869)
1993
40
Repetitive monomorphic ventricular tachycardia in a 4-year-old boy with toxic multinodular goiter. (1714224)
1991
41
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
42
Treatment of non-toxic multinodular goiter with radioactive iodine. (3337130)
1988
43
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
46
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
47
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
48
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
49
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN
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Compounds for genes affiliated with Multinodular Goiter

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46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1carbimazole46 1211.0TSHR, TPO
2amino acid4610.0TPO, TSHR
3maltose46 1210.9TPO, TSHR
4iodotyrosine46 2510.8TG, TPO
5diiodotyrosine469.8TPO, TG
6gliadin469.7TG, TPO
7chromium469.7TPO, TG
8111in-pentetreotide469.7CALCA, TG
9deoxyribonucleic acid469.7GNAS, TSHR
10amiodarone46 52 30 1212.7TPO, TG
11cardiolipin46 1210.6TG, TPO
12spec-t469.6CALCA, TG
13asparagine469.5TSHR, TPO, GNAS
14propylthiouracil46 3 1211.4TPO, TG, TSHR
15125i469.4TSHR, TG, TPO
16methimazole46 3 1211.4TSHR, TG, TPO
17selenium46 2510.4TPO, TG
18histidine469.4TSHR, TPO, GNAS
19sialic acid469.3GNAS, TG, TSHR
20hydrocortisone46 3 62 1212.3TPO, TG, CALCA
21octreotide46 62 30 1212.2CALCA, TG, GNAS
22acetylcholine46 52 30 25 1213.2CALCA, TG, TPO
23glutamine469.1GNAS, TG, TSHR
24thymidine46 2510.1TSHR, TG, GNAS
25norepinephrine46 25 1211.1GNAS, TG, CALCA
26aspartate469.1TSHR, TG, TPO
27oligonucleotide469.1TSHR, TPO, GNAS
28cyclic amp46 2510.1GNAS, TSHR, CALCA
29creatinine469.1CALCA, TG, TPO
30chloride469.0SLC26A4, TPO, GNAS
31perchlorate469.0TPO, TG, SLC26A4
32acth469.0CALCA, TSHR, TPO, GNAS
33forskolin46 52 1211.0GNAS, TPO, TSHR, CALCA
34ribonucleic acid468.9GNAS, TPO, TG, TSHR
35polysaccharide468.9GNAS, TPO, TG, TSHR
36guanine46 25 1210.8GNAS, TG, TSHR, CALCA
37arginine468.8TSHR, TG, TPO, GNAS
38cysteine468.8GNAS, TPO, TG, TSHR
39sodium iodide468.6TPO, TG, TSHR, SLC26A4
40iodide46 259.6SLC26A4, TSHR, TG, TPO
41triiodothyronine468.6SLC26A4, TSHR, TG, TPO
42testosterone46 62 25 1211.6CALCA, TG, TPO
43sodium46 259.6TPO, TG, TSHR, SLC26A4
44nitric oxide46 25 1210.5GNAS, TPO, CALCA, SLC26A4
45h2o2468.5TPO, TG, SLC26A4
46adenylate468.4GNAS, TPO, TG, TSHR, CALCA
47glutamate468.4GNAS, TPO, TG, TSHR, CALCA
48iodine46 259.1SLC26A4, TSHR, TG, TPO, GNAS
49thyroxine46 259.1TPO, TG, TSHR, CALCA, SLC26A4
50tyrosine468.0GNAS, TPO, TG, TSHR, SLC26A4

GO Terms for genes affiliated with Multinodular Goiter

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17Gene Ontology
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Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.4CALCA, GNAS
3thyroid hormone generationGO:0065909.4TG, TPO
4activation of adenylate cyclase activityGO:0071909.3GNAS, CALCA
5positive regulation of cAMP biosynthetic processGO:0308199.1CALCA, GNAS

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3CALCA, TG

Products for genes affiliated with Multinodular Goiter

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Sources for Multinodular Goiter

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet