MCID: MLT008
MIFTS: 46

Multinodular Goiter malady

Summaries for Multinodular Goiter

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Toxic multinodular goiter (also known as toxic nodular goiter, toxic nodular struma) is a common cause... more...

MalaCards: Multinodular Goiter is related to nontoxic goiter and graves' disease. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and heart, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Description from OMIM:47 138800

Aliases & Classifications for Multinodular Goiter

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 47OMIM
See all sources

Aliases & Descriptions:

multinodular goiter 8 45 61


External Ids:

Disease Ontology8 DOID:0050489
OMIM47 138800

Related Diseases for Multinodular Goiter

Sources:
17GeneCards, 18GeneDecks
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Diseases in the goiter, multinodular 1, with or without sertoli-leydig cell tumors family:

multinodular goiter goiter, multinodular, 3
goiter, multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1nontoxic goiter31.1TSHR, TPO, TG
2graves' disease31.1TSHR, GNAS
3thyroid cancer31.0TG, TPO, TSHR, KRT19, SLC26A4, TRH
4papillary carcinoma31.0TPO, ADCY10, TSHR, KRT19, SLC26A4, NKX2-1
5adenoma31.0HSPG2, VHL, CALCA, GNAS, NKX2-1, TRH
6endemic goiter30.8TSHR, TPO, TG
7thyrotoxicosis30.8TRH, TSHR, TPO, TG
8thyroid adenoma30.6GNAS, TSHR, TPO, TG
9nodular goiter30.4CALCA, KRT19, TSHR, TPO, TG
10thyroiditis30.4TG, TPO, TSHR, TRH, CALCA
11thymoma30.2NKX2-1
12hypoparathyroidism30.2CALCA
13fibrous dysplasia30.2GNAS, ADCY10
14plummer's disease30.2TPO, TG
15renal clear cell carcinoma30.2VHL
16hyperthyroxinemia30.2TRH, TSHR, TPO
17acromegaly30.2ADCY10, TRH, GNAS
18tuberculosis30.2CP, TPO, ADCY10
19congenital hypothyroidism30.2GNAS, NKX2-1, TSHR, TPO, TG
20primary hyperparathyroidism10.5
21daneman davy mancer syndrome10.4
22substernal goiter10.4
23goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
24sertoli-leydig cell tumor10.3
25sertoli cell tumor10.3
26horner's syndrome10.3
27lingual goiter10.1
28acute thyroiditis10.1
29suppurative thyroiditis10.1
30parathyroid carcinoma10.1
31colon lymphoma10.1
32bone carcinoma10.1
33mccune albright syndrome10.1
34thyroid lymphoma10.1
35allergic rhinitis10.1
36cellulitis10.1
37alveolar rhabdomyosarcoma10.1
38pemphigus10.1
39cowden disease10.1
40extramedullary plasmacytoma10.1
41papillary adenoma10.1
42thyroid gland disease10.1
43vascular cancer10.1
44mccune–albright syndrome10.1
45clear cell renal cell carcinoma10.1
46pemphigus foliaceus10.1
47superior vena cava syndrome10.1
48virilizing ovarian tumor10.1
49familial papillary thyroid carcinoma10.1
50dysalbuminemic hyperthyroxinemia10.1

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Clinical Features for Multinodular Goiter

Sources:
47OMIM
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Clinical features from OMIM:

138800

Drugs & Therapeutics for Multinodular Goiter

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Multinodular Goiter

Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Search CenterWatch for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Anatomical Context for Multinodular Goiter

Sources:
33MalaCards
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MalaCards organs/tissues related to Multinodular Goiter:

33
Lymph node, Lung, Heart, Colon, Thyroid, Salivary gland, Breast, Nk cells, T cells, B cells, Endothelial, Trachea, Pituitary

Animal Models for Multinodular Goiter or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Multinodular Goiter

Sources:
51PubMed
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Articles related to Multinodular Goiter:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Toxic multinodular goiter: an unusual cause of pleural effusion. (23609264)
2013
2
Experience with total thyroidectomy for massive multinodular goiter. (23896257)
2013
3
Novel DICER1 mutation as cause of multinodular goiter in children. (23728841)
2013
4
The association between development and progression of multinodular goiter and thyroid-stimulating hormone receptor gene D727E and P52T polymorphisms. (23336574)
2013
5
Long-term efficacy of modified-release recombinant human TSH (MRrhTSH) augmented radioiodine (131I) therapy for benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled dose-selection study. (24341527)
2013
6
Intraoperative thyroid storm in a patient with euthyroid multinodular goiter. (23385045)
2012
7
Total thyroidectomy for non-toxic multinodular goiter with versus without the use of harmonic FOCUS dissecting shears - a prospective randomized study. (23362426)
2012
8
Indications for surgery and significance of unrecognized cancer in endemic multinodular goiter. (22395348)
2012
9
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
10
Approach to the patient with nontoxic multinodular goiter. (21543434)
2011
11
Total thyroidectomy for the surgical treatment of multinodular goiter. (21365410)
2011
12
Solitary extramedullary plasmacytoma of the thyroid gland associated with multinodular goiter: case report and review of the literature. (22007566)
2011
13
The association between multinodular goiter and thyroid cancer. (20938421)
2010
14
Terminal ligature of inferior thyroid artery branches during total thyroidectomy for multinodular goiter is associated with higher postoperative calcium and PTH levels. (20952270)
2010
15
Anaplastic thyroid carcinoma arising in long-standing multinodular goiter following radioactive iodine therapy: report of a case diagnosed by fine needle aspiration. (19798888)
2009
16
Lateral cervical ectopic thyroid masses with eutopic multinodular goiter: an unusual presentation. (19570743)
2009
17
The feasibility of total or near-total bilateral thyroidectomy for the treatment of bilateral multinodular goiter. (19466657)
2009
18
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
19
Treatment and prevention of recurrence of multinodular goiter: an evidence-based review of the literature. (18305998)
2008
20
Graves' disease and thyroid associated ophthalmopathy following radioiodine therapy in euthyroid multinodular goiter. (18466082)
2008
21
Dyspnea and stridor due to multinodular goiter in an obese woman. (22967919)
2008
22
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
23
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
24
H-RAS gene expression in human multinodular goiter. (17290351)
2007
25
Riedel's thyroiditis occurring in a multinodular goiter, mimicking thyroid cancer. (17554052)
2007
26
Thyroid cancer in toxic and non-toxic multinodular goiter. (17699987)
2007
27
Mismatch of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and Tc-99m pertechnetate single photon emission computed tomography (SPECT) in a euthyroid multinodular goiter. (17179794)
2007
28
Tracheopexy for tracheomalacia complicating a giant multinodular goiter: a case report. (17966550)
2007
29
Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain. (16490887)
2006
30
Surgical management of multinodular goiter with compression symptoms. (15655205)
2005
31
Utility of frozen-section examination for diagnosis of malignancy associated with multinodular goiter. (15320972)
2004
32
Enhanced detection of a parathyroid adenoma following radioiodine treatment of concurrent, toxic multinodular goiter. (15483492)
2004
33
Anaplastic thyroid carcinoma with destructive thyrotoxicosis in a patient with preexisting multinodular goiter. (15072705)
2004
34
High serum circulating telopeptide type I in multinodular goiter. (12920662)
2003
35
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
36
Multinodular goiter: surgical management and histopathological findings. (12064511)
2002
37
Ultrasonography in the diagnosis of cancer in multinodular goiter. (12240909)
2002
38
Non-hyperfunctioning nodules from multinodular goiters: a minor role in pathogenesis for somatic activating mutations in the TSH-receptor and Gsalpha subunit genes. (11407651)
2001
39
Surgical treatment of multinodular goiter: incidence of lesions of the recurrent nerves after total thyroidectomy. (11324993)
2000
40
Germline polymorphism of codon 727 of human thyroid-stimulating hormone receptor is associated with toxic multinodular goiter. (10487707)
1999
41
Diffuse nontoxic and multinodular goiter. (9174716)
1997
42
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
43
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. (8778168)
1996
44
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
45
Multinodular goiter causing airway obstruction. (1552735)
1992
46
Free triiodothyronine toxicosis in a patient with multinodular goiter. (2346164)
1990
47
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
48
Relationships between serum thyrotropin, serum free thyroxine (T4), and 3,5,3'-triiodothyronine (T3) and the daily T4 and T3 production rates in euthyroid patients with multinodular goiter. (3597707)
1987
49
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
50
An autosomal dominant form of adolescent multinodular goiter. (3799599)
1986

Genetic Variations for Multinodular Goiter

Expression for genes affiliated with Multinodular Goiter

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Multinodular Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.1TSHR, TPO, TG
3
Hide members
10.1TSHR, SLC26A4, GNAS
410.1ADCY10, GNAS, CALCA

Compounds for genes affiliated with Multinodular Goiter

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 2BitterDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2411.6TG, TPO
2diiodotyrosine4510.5TG, TPO
3forskolin45 50 1112.5CALCA, NKX2-1, TSHR
4perchlorate4510.5TG, TPO, SLC26A4
5propylthiouracil45 2 1112.5TG, TPO, TSHR
6glutamate4510.5TPO, TRH, GNAS
7125i4510.4TSHR, TPO, TG
8estrogen4510.4TRH, TSHR, TG
9iodide45 2411.4TG, TPO, SLC26A4, NKX2-1
10dopamine45 29 11 2413.4TGFB3, TRH, GNAS
11iloprost45 60 29 1113.3ADCY10, GNAS, HSPG2
12cycloheximide4510.3HSPG2, TRH, ADCY10
13acth4510.3TPO, TSHR, TRH, GNAS
14sodium iodide4510.3NKX2-1, SLC26A4, TSHR, TPO, TG
15spec-t4510.3TG, CP, CALCA
16sialic acid4510.3GNAS, TSHR, CP, TG
17atropine45 29 1112.2HSPG2, CALCA, TRH, ADCY10
18hydrocortisone45 2 60 1113.2TG, TPO, TRH, CALCA
19triiodothyronine4510.2TRH, SLC26A4, TSHR, TPO, TG
20methimazole45 2 1112.2TG, CP, TPO, TSHR, TRH
21octreotide45 60 29 1113.2CALCA, GNAS, TRH, ADCY10, TG
22fluoride4510.2HSPG2, CALCA, ADCY10
23carbohydrates4510.1KRT19, TSHR, CP, TG
24iodine45 2411.1TG, TPO, TSHR, SLC26A4, TRH, GNAS
25guanine45 11 2412.1HSPG2, CALCA, GNAS, TSHR, ADCY10, TG
26ibmx45 29 6012.1HSPG2, CALCA, TRH, ADCY10, TGFB3
27inositol 1,4,5 trisphosphate4510.1HSPG2, TRH, TSHR, ADCY10
28gnrh4510.1HSPG2, GNAS, NKX2-1, TRH, TGFB3
29norepinephrine45 11 2412.0CALCA, GNAS, TRH, ADCY10, TG
30acetylcholine45 50 29 11 2414.0HSPG2, CALCA, TRH, ADCY10, TPO, TG
31clonidine45 29 1112.0ADCY10, TRH, CALCA
32paraffin4510.0NKX2-1, KRT19, TSHR, TG, TGFB3
33ribonucleic acid459.9GNAS, NKX2-1, KRT19, TSHR, TPO, TG
34thyroxine45 2410.9CALCA, TRH, SLC26A4, TSHR, TPO, CP
35thapsigargin45 6010.9HSPG2, TRH, ADCY10, TG
36thymidine45 2410.9GNAS, TRH, KRT19, TSHR, TG, TGFB3
37adenosine 3,5-cyclic monophosphorothioate459.9ADCY10, CALCA
38serine459.9VHL, GNAS, NKX2-1, KRT19, TSHR
39progesterone45 60 29 11 2413.9TGFB3, TSHR, KRT19, TRH, NKX2-1, GNAS
40arginine459.8GNAS, TRH, TSHR, ADCY10, TPO, CP
41oligonucleotide459.8VHL, GNAS, NKX2-1, TRH, TSHR, TPO
42glutamine459.8HSPG2, GNAS, TSHR, CP, TG
43testosterone45 60 11 2412.8CALCA, TRH, KRT19, TPO, CP, TG
44cyclic amp45 2410.7HSPG2, CALCA, GNAS, NKX2-1, TRH, TSHR
45retinoic acid45 2410.7HSPG2, NKX2-1, KRT19, TSHR, TPO, CP
46vegf459.7HSPG2, VHL, CALCA, KRT19, TSHR, CP
47dexamethasone45 50 29 1112.7HSPG2, NKX2-1, TRH, ADCY10, CP, TGFB3
48adenylate459.7HSPG2, CALCA, GNAS, TRH, TSHR, ADCY10
49tyrosine459.3HSPG2, VHL, GNAS, NKX2-1, TRH, SLC26A4
50calcium45 50 11 2412.0HSPG2, VHL, CALCA, GNAS, TRH, KRT19

GO Terms for genes affiliated with Multinodular Goiter

Sources:
16Gene Ontology
See all sources

Cellular components related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TGFB3, TG, CP, TRH, GNAS, CALCA

Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.2TG, TPO
2cAMP biosynthetic processGO:00617110.1ADCY10, GNAS
3hormone biosynthetic processGO:0424469.9TG, TPO

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.2ADCY10, GNAS

Products for genes affiliated with Multinodular Goiter

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multinodular Goiter

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet