MCID: MLT008
MIFTS: 41

Multinodular Goiter malady

Categories: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050489

Summaries for Multinodular Goiter

Disease Ontology : 12 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary : Multinodular Goiter is related to endemic goiter and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are G alpha (s) signalling events and Insulin secretion. The drugs Autoantibodies and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Multinodular Goiter

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 endemic goiter 29.8 CALCA TG TPO TSHR
2 goiter, multinodular 1, with or without sertoli-leydig cell tumors 11.8
3 graves' disease 11.4
4 daneman davy mancer syndrome 11.2
5 short stature, microcephaly, and endocrine dysfunction 11.2
6 cln4 disease 11.0
7 goiter, multinodular, cystic renal disease, and digital anomalies 11.0
8 myopathy - thyrotoxic 11.0
9 thyroid cancer, nonmedullary, 4 11.0
10 goiter 11.0
11 thyroiditis 10.7
12 adenoma 10.3
13 hyperthyroidism 10.3
14 hyperthyroidism, familial gestational 10.3 GNAS TSHR
15 fibrous meningioma 10.3 TG TPO
16 premature closure of the arterial duct 10.3 TG TPO
17 thyroid cancer 10.3
18 tick paralysis 10.2 TG TPO
19 frontal sinusitis 10.2 TG TPO
20 chromophil adenoma of the kidney 10.2 NKX2-1 TG
21 caudal regression syndrome 10.2 TG TPO
22 color blindness 10.2 TG TPO
23 kidney disease 10.2 NKX2-1 TG
24 echinostomiasis 10.2 SLC26A4 TG
25 endophthalmitis 10.2 CALCA TG
26 bone deterioration disease 10.2 DICER1 NKX2-1
27 corneal ectasia 10.2 CALCA TG
28 superior vena cava angiosarcoma 10.2 CALCA TG
29 conjunctival deposit 10.2 TG TPO TSHR
30 mixed eosinophil-basophil adenoma 10.2 TG TPO TSHR
31 exudative glomerulonephritis 10.2 DICER1 NKX2-1
32 hypothyroidism, congenital, nongoitrous, 1 10.2 TG TPO TSHR
33 mesenchymal cell neoplasm 10.2 CALCA GNAS
34 denys-drash syndrome 10.2 TG TPO TSHR
35 perineural angioma 10.2 CALCA TG
36 janus kinase-3 deficiency 10.2 TG TPO TSHR
37 parietal lobe neoplasm 10.2 CALCA TG
38 potter's syndrome 10.1 PAX8 TSHR
39 hypogonadism cardiomyopathy 10.1 CALCA TG
40 parathyroid adenoma 10.1
41 hyperparathyroidism 10.1
42 articulation disorder 10.1 TG TPO TSHR
43 duodenal obstruction 10.1 DICER1 NKX2-1
44 bladder flat intraepithelial lesion 10.1 PAX8 TG
45 parachordoma 10.1 NKX2-1 TG TSHR
46 acute laryngitis 10.1 TG TSHR
47 papillary carcinoma 10.1
48 childhood vagina botryoid rhabdomyosarcoma 10.1 CALCA TG
49 glomangiomyoma 10.0 GNAS TG TPO TSHR
50 pulsating exophthalmos 10.0 GNAS TG TPO TSHR

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to Multinodular Goiter

Symptoms & Phenotypes for Multinodular Goiter

MGI Mouse Phenotypes related to Multinodular Goiter:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
2 growth/size/body region MP:0005378 10.11 DICER1 GNAS HRAS NKX2-1 PAX8 TG
3 homeostasis/metabolism MP:0005376 10.1 SLC26A4 TG TPO TSHR XRCC4 DICER1
4 nervous system MP:0003631 9.91 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
5 craniofacial MP:0005382 9.89 DICER1 GNAS HRAS PAX8 XRCC4
6 hearing/vestibular/ear MP:0005377 9.83 GNAS PAX8 SLC26A4 TPO TSHR
7 neoplasm MP:0002006 9.8 DICER1 GNAS HRAS NKX2-1 TSHR XRCC4
8 limbs/digits/tail MP:0005371 9.77 DICER1 GNAS PAX8 TPO TSHR
9 renal/urinary system MP:0005367 9.55 DICER1 GNAS HRAS PAX8 SLC26A4
10 reproductive system MP:0005389 9.43 NKX2-1 PAX8 SLC26A4 TSHR XRCC4 DICER1
11 skeleton MP:0005390 9.28 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4

Drugs & Therapeutics for Multinodular Goiter

Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Phase 4
2 Coagulants Phase 2, Phase 3
3 Hemostatics Phase 2, Phase 3
4
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
5 Calcitonin Gene-Related Peptide Phase 2
6 calcitonin Phase 2
7 Hormones Phase 2,Phase 1
8 Bone Density Conservation Agents Phase 2
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11
Iodine 7553-56-2 807
12 cadexomer iodine
13 Anesthetics

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4
2 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
3 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2
4 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2
5 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2
6 Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1
7 Budget Impact of Harmonic FOCUS in Thyroidectomy Unknown status NCT01658085
8 Three-Year Follow-up of Radioiodine Therapy for Goitre Completed NCT00509483
9 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288
10 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
11 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551
12 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease Completed NCT00666315
13 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565
14 Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
15 Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules Completed NCT00571090
16 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
17 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
18 Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer Withdrawn NCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Genetic tests related to Multinodular Goiter:

id Genetic test Affiliating Genes
1 Multinodular Goiter 29

Anatomical Context for Multinodular Goiter

MalaCards organs/tissues related to Multinodular Goiter:

39
Thyroid, Bone, Lung, Trachea, Colon, Pituitary, Endothelial

Publications for Multinodular Goiter

Articles related to Multinodular Goiter:

(show top 50) (show all 313)
id Title Authors Year
1
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
2
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
3
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
4
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
5
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
6
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
7
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
8
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
9
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
10
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
11
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
12
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
13
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
14
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
15
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
16
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? ( 28005977 )
2016
17
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. ( 26982637 )
2016
18
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
19
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. ( 26871832 )
2016
20
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. ( 27988915 )
2016
21
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. ( 27011525 )
2015
22
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. ( 26319784 )
2015
23
Large multinodular goiter--outpatient radioiodine treatment. ( 26323466 )
2015
24
The Natural History of Multinodular Goiter. ( 26364072 )
2015
25
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? ( 26702247 )
2015
26
Thyroid storm associated with multinodular goiter: a difficult problem to treat. ( 25772969 )
2015
27
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? ( 25594634 )
2015
28
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. ( 25981745 )
2015
29
Bone Marrow Metaplasia in Multinodular Goiter With Primary Hyperparathyroidism. ( 25310511 )
2014
30
Multinodular goiter with retrosternal extension causing airway obstruction: Management in intensive care unit and operating room. ( 25136197 )
2014
31
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter. ( 25451712 )
2014
32
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. ( 24555692 )
2014
33
Trigeminal autonomic headaches caused by a multinodular goiter--a case report. ( 24628230 )
2014
34
Multinodular Goiter in children: an important pointer to a germline DICER1 mutation. ( 24628552 )
2014
35
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
36
Congenital thyroid hemiagenesis with multinodular goiter. ( 25379177 )
2014
37
Adenomatous multinodular goiter causing airway obstruction in an infant. ( 24622964 )
2014
38
Toxic multinodular goiter in a patient with end-stage renal disease and hemodialysis. ( 25089233 )
2014
39
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. ( 25189867 )
2014
40
Anaplastic carcinoma and toxic multinodular goiter: an unusual presentation. ( 25759806 )
2014
41
Overview of thyroid physiology: an essential for understanding familial euthyroid multinodular goiter. ( 23882995 )
2013
42
Familial multinodular goiter syndrome with papillary thyroid carcinomas: mutational analysis of the associated genes in 5 cases from 1 Chinese family. ( 24144365 )
2013
43
Ectopic lingual thyroid with a multinodular goiter. ( 22001633 )
2013
44
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. ( 23671549 )
2013
45
Unilateral thyroidectomy for the treatment of benign multinodular goiter. ( 23688788 )
2013
46
Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis. ( 23067375 )
2013
47
Total Thyroidectomy for Multinodular Goiter. Possibility of Implementation in aA District Hospital. ( 23585205 )
2013
48
Novel DICER1 mutation as cause of multinodular goiter in children. ( 23728841 )
2013
49
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. ( 24253155 )
2013
50
Experience with total thyroidectomy for massive multinodular goiter. ( 23896257 )
2013

Variations for Multinodular Goiter

Expression for Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for Multinodular Goiter

GO Terms for Multinodular Goiter

Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cAMP biosynthetic process GO:0030819 9.5 CALCA GNAS TSHR
2 hormone biosynthetic process GO:0042446 9.43 TG TPO
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.43 CALCA GNAS TSHR
4 positive regulation of adenylate cyclase activity GO:0045762 9.4 CALCA TSHR
5 iodide transport GO:0015705 9.37 SLC26A4 TG
6 activation of adenylate cyclase activity GO:0007190 9.33 CALCA GNAS TSHR
7 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
8 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Multinodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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