MCID: MLT008
MIFTS: 47

Multinodular Goiter malady

Summaries for Multinodular Goiter

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A multinodular goiter is a multinodular enlargment of the thyroid gland. more...

MalaCards: Multinodular Goiter is related to goiter and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Allograft rejection. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and trachea, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Description from OMIM:46 138800

Aliases & Classifications for Multinodular Goiter

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8Disease Ontology, 44Novoseek, 60UMLS, 46OMIM
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Aliases & Descriptions:

multinodular goiter 8 44 60


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Disease Ontology8 DOID:0050489
OMIM46 138800

Related Diseases for Multinodular Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Multinodular Goiter family:

Goiter, Multinodular, 3 Goiter, Multinodular, 2

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1goiter32.0TG, TPO, TSHR, SLC26A4, TRH, NKX2-1
2thyroiditis31.6TG, TPO, TSHR, TRH, CALCA
3nontoxic goiter31.1TSHR, TPO, TG
4graves' disease31.0TSHR, GNAS
5thyroid cancer30.9TG, TPO, TSHR, KRT19, SLC26A4, TRH
6hyperthyroidism30.9GNAS, TRH, TSHR, ADCY10, TPO, TG
7papillary carcinoma30.9TPO, ADCY10, TSHR, KRT19, SLC26A4, NKX2-1
8adenoma30.9HSPG2, VHL, CALCA, GNAS, NKX2-1, TRH
9papillary thyroid carcinoma30.9TG, TPO, TSHR
10endemic goiter30.7TSHR, TPO, TG
11thyrotoxicosis30.7TRH, TSHR, TPO, TG
12parathyroid adenoma30.7GNAS, CALCA
13hyperparathyroidism30.7ADCY10, CALCA
14follicular thyroid carcinoma30.5CALCA, TSHR, ADCY10, TG
15plummer's disease30.4TPO, TG
16leydig cell tumor30.4ADCY10, GNAS
17nodular goiter30.4CALCA, KRT19, TSHR, TPO, TG
18hypothyroidism30.4GNAS, NKX2-1, TRH, SLC26A4, TSHR, ADCY10
19thymoma30.1NKX2-1
20hypoparathyroidism30.1CALCA
21lung cancer30.1NKX2-1, KRT19
22fibrous dysplasia30.1GNAS, ADCY10
23renal clear cell carcinoma30.1VHL
24hyperthyroxinemia30.1TRH, TSHR, TPO
25acromegaly30.1ADCY10, TRH, GNAS
26tuberculosis30.1CP, TPO, ADCY10
27obesity30.1ADCY10, TRH, GNAS
28congenital hypothyroidism30.1GNAS, NKX2-1, TSHR, TPO, TG
29melanoma30.1HSPG2, NKX2-1, TSHR, CP, TGFB3
30primary hyperparathyroidism10.5
31daneman davy mancer syndrome10.4
32substernal goiter10.4
33goiter, multinodular 1, with or without sertoli-leydig cell tumors10.4
34sertoli-leydig cell tumor10.3
35sertoli cell tumor10.3
36horner's syndrome10.3
37renal cell carcinoma10.3
38lingual goiter10.1
39acute thyroiditis10.1
40suppurative thyroiditis10.1
41parathyroid carcinoma10.1
42colon lymphoma10.1
43bone carcinoma10.1
44mccune albright syndrome10.1
45thyroid lymphoma10.1
46allergic rhinitis10.1
47cellulitis10.1
48alveolar rhabdomyosarcoma10.1
49pemphigus10.1
50extramedullary plasmacytoma10.1

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Clinical Features for Multinodular Goiter

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46OMIM
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Clinical features from OMIM:

138800

Drugs & Therapeutics for Multinodular Goiter

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Multinodular Goiter

Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Search CenterWatch for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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32MalaCards
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MalaCards organs/tissues related to Multinodular Goiter:

32
Thyroid, Bone, Trachea, T cells, Pituitary, Colon, Lung, Breast, Heart, Endothelial, Lymph node, Salivary gland

Animal Models for Multinodular Goiter or affiliated genes

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36MGI
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Publications for Multinodular Goiter

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50PubMed
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Articles related to Multinodular Goiter:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
2
Overview of thyroid physiology: an essential for understanding familial euthyroid multinodular goiter. (23882995)
2013
3
Prevalence of Thyroid Cancer in Multinodular Goiter Versus Single Nodule: Iodine Intake and Cancer Phenotypes. (23991912)
2013
4
A Novel, Homozygous c.1502T>G (p.Val501Gly) Mutation in the Thyroid peroxidase Gene in Malaysian Sisters with Congenital Hypothyroidism and Multinodular Goiter. (23737781)
2013
5
A giant euthyroid endemic multinodular goiter with no obstructive or compressive symptoms. (21716700)
2011
6
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. (21919698)
2011
7
Tuberculosis of the thyroid presenting as multinodular goiter with hypothyroidism: a rare presentation. (20699540)
2010
8
Trace elements status in multinodular goiter. (20413068)
2010
9
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
10
Graves' disease occurring after surgery of a multinodular goiter: a case report. (18563680)
2009
11
High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/clinical hyperthyroidism. (19678745)
2009
12
A 30-year perspective on radioiodine therapy of benign nontoxic multinodular goiter. (19623060)
2009
13
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
14
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
15
Thiamazole as an adjuvant to radioiodine for volume reduction of multinodular goiter. (19012495)
2008
16
Subtotal and near total versus total thyroidectomy for the management of multinodular goiter. (18340482)
2008
17
Is total thyroidectomy the surgical procedure of choice for benign multinodular goiter? An evidence-based review. (18449595)
2008
18
Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues. (18058265)
2007
19
Management of multinodular goiter in Germany (Papillon 2005): do the approaches of thyroid specialists and primary care practitioners differ? (17549317)
2007
20
Symptomatic benign multinodular goiter: unilateral or bilateral thyroidectomy? (17950336)
2007
21
LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter: a prospective randomized study. (17309966)
2007
22
Peripheral blood levels of thyroglobulin mRNA and serum thyroglobulin concentrations after radioiodine ablation of multinodular goiter with or without pre-treatment with recombinant human thyrotropin. (17848834)
2007
23
The preoperative exclusion of thyroid carcinoma in multinodular goiter: Dynamic contrast-enhanced magnetic resonance imaging versus ultrasonography-guided fine-needle aspiration biopsy. (18063087)
2007
24
Images in clinical medicine. Endemic multinodular goiter. (17596597)
2007
25
The advantage of near-total thyroidectomy to avoid postoperative hypoparathyroidism in benign multinodular goiter. (17021791)
2006
26
Total thyroidectomy for multinodular goiter in the elderly. (16105529)
2005
27
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. (16029132)
2005
28
Application of mouse monoclonal antibodies for identification of antigen regions of human thyroid peroxidase in adolescents with Graves' disease and non-toxic multinodular goiter by flow cytometry. (16390813)
2005
29
Oxidation products and antioxidant markers in plasma of patients with Graves' disease and toxic multinodular goiter: effect of methimazole treatment. (15346657)
2004
30
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
31
Clinical value of calcifications in thyroid carcinoma and multinodular goiter. (12926167)
2003
32
Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. (11295364)
2001
33
Screening of thyrotropin receptor mutations by fine-needle aspiration biopsy in autonomous functioning thyroid nodules in multinodular goiters. (10319940)
1999
34
Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. (9467563)
1998
35
Diagnosis and radioablation treatment of toxic multinodular goiter in a hemodialysis patient. (9531189)
1998
36
Superior vena cava syndrome caused by a benign retrosternal multinodular goiter. (9257511)
1997
37
Two autonomous nodules of a patient with multinodular goiter harbor different activating mutations of the thyrotropin receptor gene. (8989278)
1997
38
Analysis of cytokine gene expression in Graves' disease and multinodular goiter. (8045947)
1994
39
Levothyroxine suppressive therapy in the medical management of nontoxic benign multinodular goiter. (8299711)
1993
40
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
41
Discordant hypothyroxinemia and hypertriiodothyroninemia in treated patients with hyperthyroid Graves' disease and toxic multinodular goiter. (1712765)
1991
42
Conservative treatment and long term prophylactic thyroxine in the prevention of recurrence of multinodular goiter. (2120782)
1990
43
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
44
Total thyroidectomy. The preferred option for multinodular goiter. (3689014)
1987
45
Standard dose 131I therapy for toxic multinodular goiter in an endemic goiter region. (3651625)
1986
46
Association of multinodular goiter, cystic renal disease, and digital anomalies. (4020555)
1985
47
Circulating immunoglobulin E (IgE) antibodies to L-thyroxine in a euthyroid patient with multinodular goiter and allergic rhinitis. (6715795)
1984
48
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
49
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Genetic Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Multinodular Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.1TSHR, TPO, TG
3
Hide members
10.1TSHR, SLC26A4, GNAS
410.1ADCY10, GNAS, CALCA

Compounds for genes affiliated with Multinodular Goiter

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Multinodular Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.6TG, TPO
2diiodotyrosine4410.5TG, TPO
3forskolin44 49 1112.5NKX2-1, CALCA, TSHR
4perchlorate4410.5TG, TPO, SLC26A4
5propylthiouracil44 2 1112.5TG, TPO, TSHR
6glutamate4410.5TPO, GNAS, TRH
7125i4410.4TPO, TSHR, TG
8estrogen4410.4TG, TSHR, TRH
9iodide44 2411.4TG, NKX2-1, SLC26A4, TPO
10dopamine44 28 11 2413.4TRH, TGFB3, GNAS
11iloprost44 59 28 1113.3ADCY10, GNAS, HSPG2
12cycloheximide4410.3ADCY10, HSPG2, TRH
13acth4410.3TSHR, TRH, GNAS, TPO
14sodium iodide4410.3NKX2-1, SLC26A4, TSHR, TPO, TG
15spec-t4410.3CP, TG, CALCA
16sialic acid4410.3GNAS, TG, TSHR, CP
17atropine44 28 1112.2CALCA, ADCY10, TRH, HSPG2
18hydrocortisone44 2 59 1113.2CALCA, TRH, TPO, TG
19triiodothyronine4410.2SLC26A4, TRH, TG, TPO, TSHR
20fluoride4410.2HSPG2, CALCA, ADCY10
21methimazole44 2 1112.2CP, TPO, TSHR, TRH, TG
22octreotide44 59 28 1113.2TG, ADCY10, CALCA, GNAS, TRH
23carbohydrates4410.1TG, CP, TSHR, KRT19
24iodine44 2411.1SLC26A4, TRH, GNAS, TG, TPO, TSHR
25guanine44 11 2412.1HSPG2, ADCY10, TG, CALCA, GNAS, TSHR
26ibmx44 28 5912.1ADCY10, TRH, TGFB3, CALCA, HSPG2
27inositol 1,4,5 trisphosphate4410.1HSPG2, TRH, TSHR, ADCY10
28gnrh4410.1TRH, GNAS, HSPG2, TGFB3, NKX2-1
29norepinephrine44 11 2412.0CALCA, GNAS, TRH, ADCY10, TG
30acetylcholine44 49 28 11 2414.0TG, HSPG2, TRH, ADCY10, TPO, CALCA
31clonidine44 28 1112.0CALCA, ADCY10, TRH
32paraffin4410.0TGFB3, TG, TSHR, KRT19, NKX2-1
33ribonucleic acid449.9TG, GNAS, NKX2-1, KRT19, TGFB3, TSHR
34thyroxine44 2410.9SLC26A4, CP, TG, TPO, TSHR, CALCA
35thapsigargin44 5910.9TG, HSPG2, TRH, ADCY10
36thymidine44 2410.9KRT19, TRH, TSHR, TGFB3, TG, GNAS
37adenosine 3,5-cyclic monophosphorothioate449.9ADCY10, CALCA
38serine449.9VHL, NKX2-1, TSHR, KRT19, GNAS
39progesterone44 59 28 11 2413.9TSHR, GNAS, NKX2-1, TRH, KRT19, TGFB3
40arginine449.8CP, TPO, ADCY10, TSHR, TRH, GNAS
41oligonucleotide449.8TSHR, VHL, GNAS, TPO, NKX2-1, TRH
42glutamine449.8HSPG2, TG, CP, TSHR, GNAS
43testosterone44 59 11 2412.8TRH, CALCA, KRT19, TGFB3, TG, CP
44cyclic amp44 2410.7TRH, CALCA, TSHR, ADCY10, NKX2-1, TGFB3
45retinoic acid44 2410.7TGFB3, HSPG2, NKX2-1, KRT19, TSHR, TPO
46vegf449.7KRT19, CP, TSHR, CALCA, TG, TGFB3
47dexamethasone44 49 28 1112.7TGFB3, ADCY10, TRH, NKX2-1, HSPG2, CP
48adenylate449.7TG, TPO, ADCY10, CP, TSHR, TRH
49tyrosine449.3TSHR, TPO, HSPG2, VHL, GNAS, TRH
50calcium44 49 11 2412.0HSPG2, VHL, CALCA, TPO, ADCY10, TSHR

GO Terms for genes affiliated with Multinodular Goiter

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16Gene Ontology
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Cellular components related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TGFB3, TG, CP, TRH, GNAS, CALCA

Biological processes related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.2TG, TPO
2cAMP biosynthetic processGO:00617110.1ADCY10, GNAS
3hormone biosynthetic processGO:0424469.9TG, TPO

Molecular functions related to Multinodular Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.2ADCY10, GNAS

Products for genes affiliated with Multinodular Goiter

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Sources for Multinodular Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet