MCID: MLT008
MIFTS: 40

Multinodular Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

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Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 11 13 25 48 66

Classifications:



External Ids:

Disease Ontology11 DOID:0050489

Summaries for Multinodular Goiter

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Disease Ontology:11 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary: Multinodular Goiter is related to nodular goiter and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Endothelin and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, bone and lung, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Related Diseases for Multinodular Goiter

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Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1nodular goiter29.3CALCA, TG, TPO
2goiter, multinodular 1, with or without sertoli-leydig cell tumors11.7
3graves' disease11.6
4daneman davy mancer syndrome11.3
5goiter, multinodular, cystic renal disease, and digital anomalies11.2
6cln4 disease11.2
7goiter11.1
8thyroiditis10.9
9hyperthyroidism, nonautoimmune10.6GNAS, TSHR
10iatrogenic or traumatic pituitary deficiency10.5TG, TPO
11ovarian endometrioid cystadenoma10.4TG, TPO
12adenoma10.4
13hyperthyroidism10.4
14peripheral scars of retina10.4TG, TPO
15presbyopia10.4TG, TSHR
16olecranon bursitis10.4PAX8, TSHR
17bone remodeling disease10.4DICER1, NKX2-1
18transient hypogammaglobulinemia of infancy10.4NKX2-1, TG
19classic pulmonary blastoma10.4DICER1, NKX2-1
20thyroid cancer10.4
21chronic frontal sinusitis10.3TG, TPO
22short stature, microcephaly, and endocrine dysfunction10.3
23adult teratoma10.3NKX2-1, TG
24hypothryoidism, congenital, nongoitrous 410.3TG, TPO
25primary hyperparathyroidism10.3
26hyperparathyroidism10.3
27parathyroid adenoma10.3
28glaucomatocyclitic crisis10.3TG, TSHR
29papillary carcinoma10.2
30tinea corporis10.2SLC26A4, TG
31uterine ligament serous adenocarcinoma10.2GNAS, HRAS
32tenosynovitis of foot and ankle10.2DICER1, PAX8
33hypertelorism, preauricular sinus, punctal pits, and deafness10.2TG, TPO, TSHR
34retinitis pigmentosa 2710.2HRAS, NKX2-1
35cd3zeta deficiency10.2TG, TPO, TSHR
36blood group incompatibility10.2TG, TPO, TSHR
37thyroid cancer, nonmedullary, 410.2
38rhabdomyosarcoma, embryonal, 210.2DICER1, TG, TPO
39intermittent proptosis10.2TG, TPO, TSHR
40malignant syringoma10.1NKX2-1, TG, TSHR
41benign mesothelioma10.1NKX2-1, TG, TSHR
42trachea adenoid cystic carcinoma10.1HRAS, NKX2-1
43leydig cell tumor10.1
44sertoli-leydig cell tumor10.1
45dysautonomia, familial10.1TG, TPO
46venezuelan equine encephalitis10.1NKX2-1, TPO
47respiratory failure10.0
48plummer's disease10.0
49horner's syndrome10.0
50endemic goiter10.0

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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Drugs & Therapeutics for Multinodular Goiter

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Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1calcitoninPhase 2104
2
Salmon CalcitoninPhase 29247931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin salmon recombinant
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
3CALCITONIN GENE-RELATED PEPTIDEPhase 292
4
Iodine5167553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
5cadexomer iodine484

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1The Role of Levothyroxine on Goiter With Atypia of Undetermined SignificanceNot yet recruitingNCT02329379Phase 4
2Clinical Trial on Harmonic Focus ShearsCompletedNCT01003652Phase 2, Phase 3
3Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular GoiterCompletedNCT00454220Phase 2
4rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
5rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
6Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating HormoneCompletedNCT00137891Phase 1
7Three-Year Follow-up of Radioiodine Therapy for GoitreCompletedNCT00509483
8Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft FunctionCompletedNCT02194920
9A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid SurgeryCompletedNCT01163565
10Swallowing Function Before and After Surgery for Thyroid GoiterCompletedNCT00205348
11Thyroid Lobectomy With or Without Levothyroxine Treatment PostoperativelyCompletedNCT00941551
12Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid DiseaseCompletedNCT00666315
13Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid NodulesCompletedNCT00571090
14Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
15Budget Impact of Harmonic FOCUS in ThyroidectomyActive, not recruitingNCT01658085
16Galectin 3 Dosage in Diagnosis of Nodular and Multinodular GoiterActive, not recruitingNCT01588288
17Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid CancerWithdrawnNCT00954837

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Genetic Tests for Multinodular Goiter

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Genetic tests related to Multinodular Goiter:

id Genetic test Affiliating Genes
1 Multinodular Goiter25

Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

34
Thyroid, Bone, Lung, Colon, Pituitary, Trachea, Endothelial

Animal Models for Multinodular Goiter or affiliated genes

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MGI Mouse Phenotypes related to Multinodular Goiter:

39 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7GNAS, PAX8, SLC26A4, TPO, TSHR
2MP:00053828.2DICER1, GNAS, HRAS, PAX8, XRCC4
3MP:00053718.1DICER1, GNAS, PAX8, TPO, TSHR
4MP:00053898.1DICER1, NKX2-1, PAX8, SLC26A4, TSHR, XRCC4
5MP:00030128.1DICER1, GNAS, HRAS, NKX2-1, PAX8
6MP:00020068.0DICER1, GNAS, HRAS, NKX2-1, TSHR, XRCC4
7MP:00053677.8DICER1, GNAS, HRAS, PAX8, SLC26A4
8MP:00053786.4DICER1, GNAS, HRAS, NKX2-1, PAX8, TG
9MP:00036316.4DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
10MP:00053906.2DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
11MP:00053796.0DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4
12MP:00053765.8DICER1, GNAS, HRAS, NKX2-1, PAX8, SLC26A4

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 306)
idTitleAuthorsYear
1
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. (26817871)
2016
2
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. (26319784)
2015
3
Congenital thyroid hemiagenesis with multinodular goiter. (25379177)
2014
4
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. (25189867)
2014
5
Adenomatous multinodular goiter causing airway obstruction in an infant. (24622964)
2014
6
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
7
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
8
Experience with total thyroidectomy for massive multinodular goiter. (23896257)
2013
9
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
10
Thyrotoxicosis: evaluation and treatment of a multinodular goiter. (22739458)
2012
11
Intraoperative thyroid storm in a patient with euthyroid multinodular goiter. (23385045)
2012
12
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
13
Mutations of GNAS and TSHR genes in subclinical toxic multinodular goiter. (20336923)
2010
14
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
15
Radioiodine therapy for multinodular goiter. (22964127)
2008
16
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
17
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
18
Multinodular goiter and primary hyperparathyroidism: a circuitous route to diagnosing metastatic uveal melanoma. (18758693)
2008
19
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
20
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
21
H-RAS gene expression in human multinodular goiter. (17290351)
2007
22
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
23
Total thyroidectomy for multinodular goiter in the elderly. (16105529)
2005
24
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
25
Pemberton's sign associated with a large multinodular goiter. (12804111)
2003
26
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
27
Multinodular goiter: surgical management and histopathological findings. (12064511)
2002
28
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
29
Multinodular Goiter (25905424)
2000
30
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
31
Solitary nodular disease and multinodular goiter: a retrospective study on suppressive versus replacement levothyroxine therapy. (10382684)
1999
32
Total thyroidectomy for multinodular goiter. (9851343)
1998
33
Superior vena cava syndrome caused by a benign retrosternal multinodular goiter. (9257511)
1997
34
Autonomous thyroid adenoma, papillary thyroid carcinoma, and ectopic parathyroid adenoma in a patient with primary hyperparathyroidism and a nontoxic multinodular goiter. (9227878)
1997
35
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
36
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
37
Immunological features of sporadic multinodular goiter. (8374249)
1993
38
Conservative treatment and long term prophylactic thyroxine in the prevention of recurrence of multinodular goiter. (2120782)
1990
39
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
40
Selective pituitary resistance to thyroid hormone after treatment of a toxic multinodular goiter. (3420449)
1988
41
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
42
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
43
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
44
An autosomal dominant form of adolescent multinodular goiter. (3799599)
1986
45
Circulating immunoglobulin E (IgE) antibodies to L-thyroxine in a euthyroid patient with multinodular goiter and allergic rhinitis. (6715795)
1984
46
Multinodular goiter in thyroid hemiagenesis. (6887850)
1983
47
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
48
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
49
Functional autonomy in multinodular goiter. (4195884)
1970
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1iodide transportGO:001570510.1SLC26A4, TG
2thyroid hormone generationGO:000659010.0TG, TPO
3thyroid-stimulating hormone signaling pathwayGO:003819410.0PAX8, TSHR
4hormone biosynthetic processGO:004244610.0TG, TPO
5activation of adenylate cyclase activityGO:00071909.8CALCA, TSHR
6feeding behaviorGO:00076319.6CALCA, NKX2-1
7thyroid gland developmentGO:00308789.5NKX2-1, PAX8, TG
8adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.1CALCA, GNAS, TSHR

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00049969.6PAX8, TSHR

Sources for Multinodular Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet