MCID: MLT008
MIFTS: 41

Multinodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

MalaCards integrated aliases for Multinodular Goiter:

Name: Multinodular Goiter 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050489

Summaries for Multinodular Goiter

Disease Ontology : 12 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary : Multinodular Goiter is related to lymphoma and endemic goiter. An important gene associated with Multinodular Goiter is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are G alpha (s) signalling events and Insulin secretion. The drugs Autoantibodies and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 72 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Related Diseases for Multinodular Goiter

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.1 TG TPO TSHR
2 endemic goiter 29.4 CALCA TG TPO TSHR
3 goiter, multinodular 1, with or without sertoli-leydig cell tumors 11.7
4 daneman davy mancer syndrome 11.7
5 short stature, microcephaly, and endocrine dysfunction 11.2
6 goiter, multinodular, cystic renal disease, and digital anomalies 11.1
7 myopathy - thyrotoxic 11.0
8 thyroid cancer, nonmedullary, 4 11.0
9 goiter 11.0
10 thyroiditis 10.7
11 hyperthyroidism, nonautoimmune 10.7 GNAS TSHR
12 adenohypophysitis 10.6 TG TPO
13 maxillary sinus adenoid cystic carcinoma 10.6 TG TPO
14 tick paralysis 10.5 TG TPO
15 chronic frontal sinusitis 10.5 TG TPO
16 hypothyroidism, congenital, nongoitrous 4 10.5 TG TPO
17 color blindness 10.4 TG TPO
18 mature teratoma 10.4 NKX2-1 TG
19 iridocyclitis 10.4 TG TSHR
20 graves' disease 10.4
21 c5 deficiency 10.4 TG TPO
22 congenital mesoblastic nephroma 10.4 DICER1 NKX2-1
23 rheumatic pulmonary valve disease 10.3 GNAS HRAS
24 adenoma 10.3
25 echinostomiasis 10.3 SLC26A4 TG
26 superior mesenteric artery syndrome 10.3 DICER1 NKX2-1
27 hyperthyroidism 10.3
28 retinitis pigmentosa 27 10.3 HRAS NKX2-1
29 amelogenesis imperfecta, hypomaturation type, iia6 10.3 TG TPO TSHR
30 cerebral lipidosis 10.3 TG TPO TSHR
31 conjunctival deposit 10.3 TG TPO TSHR
32 lung occult large cell carcinoma 10.3 TG TPO TSHR
33 combined cellular and humoral immune defects with granulomas 10.3 TG TPO TSHR
34 bone development disease 10.3 DICER1 NKX2-1
35 cd3zeta deficiency 10.3 TG TPO TSHR
36 thyroid cancer 10.3
37 childhood mediastinal neurogenic tumor 10.3 CALCA TG
38 xanthomatosis 10.3 CALCA GNAS
39 pseudohypoparathyroidism 10.3 TG TPO TSHR
40 pulsating exophthalmos 10.2 TG TPO TSHR
41 corneal ectasia 10.2 CALCA TG
42 cervical endometrial stromal sarcoma 10.2 CALCA TG
43 breast adenoid cystic carcinoma 10.2 HRAS NKX2-1
44 rhabdomyosarcoma, embryonal, 2 10.2 DICER1 TG TPO
45 congenital granular cell tumor 10.2 CALCA TG
46 parietal lobe neoplasm 10.2 CALCA TG
47 cri-du-chat syndrome 10.2 DICER1 GNAS
48 hypodermyasis 10.2 CALCA TG
49 parathyroid adenoma 10.2
50 kidney disease 10.2 NKX2-1 TG TSHR

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to Multinodular Goiter

Symptoms & Phenotypes for Multinodular Goiter

MGI Mouse Phenotypes related to Multinodular Goiter:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.13 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
2 growth/size/body region MP:0005378 10.06 DICER1 GNAS HRAS NKX2-1 PAX8 TG
3 homeostasis/metabolism MP:0005376 10.06 PAX8 SLC26A4 TG TPO TSHR DICER1
4 nervous system MP:0003631 9.86 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
5 hearing/vestibular/ear MP:0005377 9.83 GNAS PAX8 SLC26A4 TPO TSHR
6 craniofacial MP:0005382 9.8 DICER1 GNAS HRAS PAX8
7 limbs/digits/tail MP:0005371 9.77 DICER1 GNAS PAX8 TPO TSHR
8 neoplasm MP:0002006 9.72 DICER1 GNAS HRAS NKX2-1 TSHR
9 no phenotypic analysis MP:0003012 9.55 DICER1 GNAS HRAS NKX2-1 PAX8
10 renal/urinary system MP:0005367 9.35 DICER1 GNAS HRAS PAX8 SLC26A4
11 skeleton MP:0005390 9.23 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4

Drugs & Therapeutics for Multinodular Goiter

Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Phase 4
2 Coagulants Phase 2, Phase 3
3 Hemostatics Phase 2, Phase 3
4
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
5 Hormones Phase 2,Phase 1
6 Bone Density Conservation Agents Phase 2
7 calcitonin Phase 2
8 Calcitonin Gene-Related Peptide Phase 2
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11
Iodine Investigational 7553-56-2 807
12 cadexomer iodine
13 Anesthetics

Interventional clinical trials:

(show all 18)

id Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
3 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
4 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
5 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
6 Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1 Modified Release rhTSH
7 Budget Impact of Harmonic FOCUS in Thyroidectomy Unknown status NCT01658085
8 Three-Year Follow-up of Radioiodine Therapy for Goitre Completed NCT00509483
9 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288
10 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
11 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
12 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease Completed NCT00666315
13 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565
14 Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
15 Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules Completed NCT00571090
16 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
17 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
18 Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer Withdrawn NCT00954837

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Genetic tests related to Multinodular Goiter:

id Genetic test Affiliating Genes
1 Multinodular Goiter 29

Anatomical Context for Multinodular Goiter

MalaCards organs/tissues related to Multinodular Goiter:

39
Thyroid, Bone, Lung, Colon, Trachea, Pituitary, Endothelial

Publications for Multinodular Goiter

Articles related to Multinodular Goiter:

(show top 50) (show all 323)
id Title Authors Year
1
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
2
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
3
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
4
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
5
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
6
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
7
Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. ( 28506088 )
2017
8
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
9
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
10
Neglected nontoxic multinodular goiter presented as a large neck mass. ( 28265406 )
2017
11
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
12
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
13
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
14
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
15
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. ( 27988915 )
2016
16
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? ( 28005977 )
2016
17
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
18
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
19
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
20
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. ( 26871832 )
2016
21
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
22
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
23
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. ( 26982637 )
2016
24
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
25
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
26
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
27
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
28
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
29
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
30
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
31
The Natural History of Multinodular Goiter. ( 26364072 )
2015
32
Thyroid storm associated with multinodular goiter: a difficult problem to treat. ( 25772969 )
2015
33
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. ( 27011525 )
2015
34
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. ( 25981745 )
2015
35
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? ( 26702247 )
2015
36
Large multinodular goiter--outpatient radioiodine treatment. ( 26323466 )
2015
37
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? ( 25594634 )
2015
38
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. ( 26319784 )
2015
39
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. ( 24555692 )
2014
40
Congenital thyroid hemiagenesis with multinodular goiter. ( 25379177 )
2014
41
Trigeminal autonomic headaches caused by a multinodular goiter--a case report. ( 24628230 )
2014
42
Toxic multinodular goiter in a patient with end-stage renal disease and hemodialysis. ( 25089233 )
2014
43
Adenomatous multinodular goiter causing airway obstruction in an infant. ( 24622964 )
2014
44
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. ( 25189867 )
2014
45
Bone Marrow Metaplasia in Multinodular Goiter With Primary Hyperparathyroidism. ( 25310511 )
2014
46
Multinodular Goiter in children: an important pointer to a germline DICER1 mutation. ( 24628552 )
2014
47
Anaplastic carcinoma and toxic multinodular goiter: an unusual presentation. ( 25759806 )
2014
48
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
49
Multinodular goiter with retrosternal extension causing airway obstruction: Management in intensive care unit and operating room. ( 25136197 )
2014
50
DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter. ( 25451712 )
2014

Variations for Multinodular Goiter

Expression for Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for Multinodular Goiter

GO Terms for Multinodular Goiter

Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cAMP biosynthetic process GO:0030819 9.5 CALCA GNAS TSHR
2 hormone biosynthetic process GO:0042446 9.43 TG TPO
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.43 CALCA GNAS TSHR
4 positive regulation of adenylate cyclase activity GO:0045762 9.4 CALCA TSHR
5 iodide transport GO:0015705 9.37 SLC26A4 TG
6 activation of adenylate cyclase activity GO:0007190 9.33 CALCA GNAS TSHR
7 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
8 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Multinodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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