MCID: MLT008
MIFTS: 40

Multinodular Goiter malady

Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Multinodular Goiter

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS
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Aliases & Descriptions for Multinodular Goiter:

Name: Multinodular Goiter 8 44 61


Classifications:



External Ids:

Disease Ontology8 DOID:0050489

Summaries for Multinodular Goiter

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Disease Ontology:8 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary: Multinodular Goiter is related to graves' disease and thyroiditis. An important gene associated with Multinodular Goiter is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Adenylate cyclase activating neuropeptides and Endothelin. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are behavior/neurological and hematopoietic system.

Related Diseases for Multinodular Goiter

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Diseases in the Multinodular Goiter family:

Familial Multinodular Goiter

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease31.5GNAS, TSHR
2thyroiditis31.4TG, TPO, TSHR, CALCA
3goiter30.9SLC26A4, CALCA, TSHR, TG, GNAS, TPO
4parathyroid adenoma30.9CALCA, GNAS
5goiter, multinodular 1, with or without sertoli-leydig cell tumors30.9TG, TPO
6thyrotoxicosis30.8TPO, TSHR, TG
7hyperthyroidism30.7TG, TPO, GNAS, TSHR
8plummer's disease30.7TPO, TG
9hyperthyroxinemia30.6TSHR, TPO
10endemic goiter30.5TSHR, TG, TPO
11thyroid adenoma30.3GNAS, TSHR, TG, TPO
12hypothyroidism30.0SLC26A4, TPO, TSHR, TG
13nodular goiter29.9TPO, CALCA, TG, TSHR
14congenital hypothyroidism29.9TSHR, TG, TPO, GNAS
15adenoma29.8SLC26A4, CALCA, TG, TPO, GNAS, TSHR
16thyroid cancer29.8TG, SLC26A4, CALCA, TSHR, TPO, GNAS
17papillary carcinoma29.6SLC26A4, TG, GNAS, TPO, CALCA, TSHR
18follicular adenoma29.1CALCA, SLC26A4, TSHR, TG, TPO, GNAS
19familial multinodular goiter10.6
20primary hyperparathyroidism10.6
21hyperparathyroidism10.6
22thyroid hemiagenesis10.5
23sertoli-leydig cell tumor10.4
24leydig cell tumor10.4
25daneman davy mancer syndrome10.4
26osteitis fibrosa10.4GNAS
27cherubism10.4CALCA
28horner's syndrome10.3
29deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.3SLC26A4
30hypothyroidism, congenital, nongoitrous, 110.2GNAS, TSHR
31alstrom syndrome10.2
32allergic rhinitis10.2
33lung cancer10.2
34obesity10.2
35renal cell carcinoma10.2
36myasthenia gravis10.2
37pemphigus foliaceus10.2
38pemphigus10.2
39acromegaly10.2
40thyroid lymphoma10.2
41renal clear cell carcinoma10.2
42hypoparathyroidism10.2
43tracheomalacia10.2
44extramedullary plasmacytoma10.2
45fibrous dysplasia10.2
46suppurative thyroiditis10.2
47adenocarcinoma10.2
48cellulitis10.2
49cervicitis10.2
50laryngitis10.2

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to multinodular goiter

Symptoms for Multinodular Goiter

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Drugs & Therapeutics for Multinodular Goiter

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Drug clinical trials:

Search ClinicalTrials for Multinodular Goiter

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

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Anatomical Context for Multinodular Goiter

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MalaCards organs/tissues related to Multinodular Goiter:

31
Thyroid, Bone, Colon, Lung, Trachea, Pituitary, Bone marrow, Lymph node, Heart, Salivary gland, Breast, T cells, Endothelial

Animal Models for Multinodular Goiter or affiliated genes

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MGI Mouse Phenotypes related to Multinodular Goiter:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2SLC26A4, CALCA, TSHR, GNAS
2MP:00053978.2GNAS, TPO, TG, TSHR
3MP:00053908.1SLC26A4, CALCA, TPO, GNAS
4MP:00053777.9SLC26A4, CALCA, TSHR, TPO, GNAS
5MP:00053797.7GNAS, TPO, TG, TSHR, SLC26A4
6MP:00036317.6GNAS, TG, TSHR, CALCA, SLC26A4
7MP:00053767.2GNAS, TPO, TG, TSHR, CALCA, SLC26A4

Publications for Multinodular Goiter

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Articles related to Multinodular Goiter:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Thyroid storm associated with multinodular goiter: a difficult problem to treat. (25772969)
2015
2
Congenital thyroid hemiagenesis with multinodular goiter. (25379177)
2014
3
THERAPY OF ENDOCRINE DISEASE: Recombinant human TSH and radioactive therapy in the management of benign multinodular goiter. (25189867)
2014
4
Adenomatous multinodular goiter causing airway obstruction in an infant. (24622964)
2014
5
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
6
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
7
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
8
The predictive value of dominant nodules and the management of indeterminate group in multinodular goiter. (21479880)
2012
9
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
10
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
11
Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. (19525596)
2009
12
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
13
Radioiodine therapy for multinodular goiter. (22964127)
2008
14
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
15
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
16
Invasion of the recurrent laryngeal nerve by tracheal tumor: an unusual presentation with coincidental huge multinodular goiter. (19098590)
2008
17
Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. (18404277)
2008
18
Recurrence after total thyroidectomy for benign multinodular goiter. (17308855)
2007
19
Tear function and ocular surface changes in multinodular goiter patients. (17579293)
2007
20
Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter. (18086985)
2007
21
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
22
Multinodular goiter compressing the trachea following open heart surgery. (17005891)
2006
23
Sporadic C-cell hyperplasia associated with multinodular goiter]. (16929791)
2006
24
Diagnosis of multinodular goiter by endoscopic ultrasound-guided fine-needle aspiration. (17366423)
2006
25
Multinodular goiter. (12803008)
2003
26
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
27
Pemberton's sign associated with a large multinodular goiter. (12804111)
2003
28
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
29
Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)
2001
30
Multinodular Goiter (25905424)
2000
31
Multinodular goiter: the surgical procedure of choice. (10828797)
2000
32
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
33
Total thyroidectomy for multinodular goiter. (9851343)
1998
34
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
35
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
36
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
37
The relationship between hyperthyroidism and the distribution of peripheral blood T, NK and B-lymphocytes in multinodular goiter. (8200612)
1994
38
Intrathyroid salivary gland-type tissue in multinodular goiter. (7812521)
1994
39
Immunological features of sporadic multinodular goiter. (8374249)
1993
40
Association of multinodular goiter with breast carcinoma: Cowden's disease. (8144869)
1993
41
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
42
Treatment of non-toxic multinodular goiter with radioactive iodine. (3337130)
1988
43
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
44
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
45
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
46
Bilateral Horner's syndrome secondary to multinodular goiter. (3752761)
1986
47
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
48
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
49
Preclinical hyperthyroidism in multinodular goiter. (61970)
1976
50
Butanol insoluble serum iodine in patients with a non-toxic multinodular goiter. (5997275)
1966

Variations for Multinodular Goiter

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Expression for genes affiliated with Multinodular Goiter

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Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for genes affiliated with Multinodular Goiter

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Compounds for genes affiliated with Multinodular Goiter

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Compounds related to Multinodular Goiter according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1carbimazole44 1111.0TPO, TSHR
2amino acid4410.0TSHR, TPO
3maltose44 1110.9TPO, TSHR
4iodotyrosine44 2410.8TPO, TG
5diiodotyrosine449.8TG, TPO
6gliadin449.7TPO, TG
7chromium449.7TG, TPO
8111in-pentetreotide449.7TG, CALCA
9deoxyribonucleic acid449.7GNAS, TSHR
10amiodarone44 50 28 1112.7TPO, TG
11cardiolipin44 1110.6TPO, TG
12spec-t449.6CALCA, TG
13asparagine449.5TSHR, TPO, GNAS
14selenium44 2410.5TG, TPO
15propylthiouracil44 1 1111.4TPO, TSHR, TG
16125i449.4TPO, TG, TSHR
17methimazole44 1 1111.4TPO, TG, TSHR
18histidine449.4GNAS, TPO, TSHR
19sialic acid449.3GNAS, TG, TSHR
20hydrocortisone44 1 60 1112.3CALCA, TPO, TG
21octreotide44 60 28 1112.2TG, GNAS, CALCA
22acetylcholine44 50 28 24 1113.2TG, TPO, CALCA
23glutamine449.1GNAS, TSHR, TG
24thymidine44 2410.1TSHR, GNAS, TG
25norepinephrine44 24 1111.1TG, CALCA, GNAS
26aspartate449.1TG, TSHR, TPO
27oligonucleotide449.1GNAS, TPO, TSHR
28creatinine449.1CALCA, TG, TPO
29chloride449.0SLC26A4, TPO, GNAS
30cyclic amp44 2410.0TSHR, GNAS, CALCA
31perchlorate449.0TPO, TG, SLC26A4
32acth449.0TPO, GNAS, CALCA, TSHR
33forskolin44 50 1111.0CALCA, TSHR, TPO, GNAS
34ribonucleic acid448.9GNAS, TPO, TG, TSHR
35polysaccharide448.9GNAS, TG, TPO, TSHR
36guanine44 24 1110.8GNAS, CALCA, TG, TSHR
37arginine448.8TPO, TG, TSHR, GNAS
38cysteine448.8TPO, GNAS, TG, TSHR
39sodium iodide448.6TG, TPO, TSHR, SLC26A4
40iodide44 249.6TSHR, SLC26A4, TPO, TG
41triiodothyronine448.6TPO, TG, TSHR, SLC26A4
42testosterone44 60 24 1111.6CALCA, TPO, TG
43sodium44 249.6TSHR, SLC26A4, TG, TPO
44nitric oxide44 24 1110.5GNAS, TPO, CALCA, SLC26A4
45h2o2448.5SLC26A4, TG, TPO
46adenylate448.4TSHR, TG, TPO, GNAS, CALCA
47glutamate448.4CALCA, TPO, TSHR, GNAS, TG
48iodine44 249.1TG, GNAS, TPO, SLC26A4, TSHR
49thyroxine44 249.1TSHR, CALCA, TPO, SLC26A4, TG
50tyrosine448.0TG, TPO, SLC26A4, TSHR, GNAS

GO Terms for genes affiliated with Multinodular Goiter

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Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.5TG, TPO
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.4CALCA, GNAS
3thyroid hormone generationGO:00065909.4TG, TPO
4activation of adenylate cyclase activityGO:00071909.3GNAS, CALCA
5positive regulation of cAMP biosynthetic processGO:00308199.1CALCA, GNAS

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.3CALCA, TG

Sources for Multinodular Goiter

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet