MEA
MCID: MLT074
MIFTS: 43

Multiple Endocrine Neoplasia (MEA) malady

Cancer diseases, Genetic diseases categories

Summaries for Multiple Endocrine Neoplasia

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.

MalaCards: Multiple Endocrine Neoplasia, also known as adenomatosis, familial endocrine, is related to thyroiditis and thyroid medullary carcinoma. An important gene associated with Multiple Endocrine Neoplasia is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Calcium Regulation in the Cardiac Cell and Glioblastoma Multiforme. The compounds calcium and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:63 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

Aliases & Classifications for Multiple Endocrine Neoplasia

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21Genetics Home Reference, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

multiple endocrine neoplasia 21 44 60
adenomatosis, familial endocrine 21
familial endocrine adenomatosis 21
multiple endocrine adenomatosis 21
endocrine neoplasia, multiple 21
multiple endocrine neoplasms 21
men 21
mea 21


Related Diseases for Multiple Endocrine Neoplasia

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17GeneCards, 18GeneDecks
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Diseases in the Multiple Endocrine Neoplasia Type 2a family:

Multiple Endocrine Neoplasia Type 4 multiple endocrine neoplasia

Diseases related to Multiple Endocrine Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 805)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6CALCA
2thyroid medullary carcinoma31.5VHL, CALCA, GAST, MEN1, PRKAR1A, CHGA
3hyperparathyroidism31.4GAST, MEN1, PRKAR1A, CHGA, NF1, CDC73
4pheochromocytoma31.3VHL, RET, SDHD, SDHB
5obesity31.3GNAS
6zollinger-ellison syndrome31.2CHGA, MEN1, GAST
7familial medullary thyroid carcinoma31.2CALCA, GDNF, RET
8primary hyperparathyroidism31.2CALCA, GAST, MEN1, PRKAR1A, CHGA, CDC73
9gastrinoma31.2CHGA, MEN1, GAST
10neuroendocrine tumor31.1CALCA, CHGA
11adenoma31.1VHL, CALCA, GNAS, GAST, MEN1, PRKAR1A
12insulinoma31.1CHGA, MEN1, GAST, CALCA
13wermer syndrome31.0PRKAR1A, CHGA, NF1, CNC, CDC73, CDKN1B
14hirschsprung's disease30.9GDNF, RET
15pituitary adenoma30.9GNAS, MEN1, PRKAR1A, CHGA, CNC, CDKN1B
16neuroma30.9CALCA, GDNF, RET
17multiple endocrine neoplasia type 2a30.9NF1, CDC73, GDNF, RET, SDHD, SDHB
18phaeochromocytoma30.9CALCA, CHGA, RET, SDHD, SDHB, SDHC
19thyroid cancer30.8CALCA, GNAS, CDKN1B, RET
20prolactinoma30.8GNAS, MEN1, PRKAR1A, CHGA
21von hippel-lindau disease30.8VHL, MEN1, NF1, RET, SDHD, SDHB
22papillary carcinoma30.7CALCA, GNAS, CHGA, CDKN1B, RET
23acromegaly30.7GNAS, MEN1, PRKAR1A, CNC
24parathyroid carcinoma30.7MEN1, CDC73
25papillary thyroid carcinoma30.7RET, MEN1, CALCA
26duodenitis30.7GAST
27paraganglioma30.7VHL, CALCA, GAST, MEN1, CHGA, NF1
28cushing's syndrome30.6CALCA, GNAS, MEN1, PRKAR1A, CHGA, CNC
29adrenal adenoma30.6CNC, PRKAR1A, MEN1, GNAS
30parathyroid adenoma30.6RET, CDKN1B, CDC73, CHGA, CALCA, GNAS
31neuroendocrine carcinoma30.6CALCA, GAST, MEN1, CHGA
32ganglioneuroma30.6RET, CHGA
33neurofibromatosis30.6NF1, SDHD, SDHB
34colorectal cancer30.5CDKN1B, NF1, MEN1, GAST
35hypercalcemia30.5CALCA, GAST, MEN1, PRKAR1A, CHGA, CDC73
36carney complex30.5GNAS, MEN1, PRKAR1A, CDKN1B
37diabetes mellitus30.5CALCA
38vipoma30.3GAST, MEN1, CHGA
39melanoma30.3NF1, CDKN1B, GDNF
40prostate cancer30.3GNAS, CHGA, CDKN1B, SDHC
41lung cancer30.3CHGA
42sarcoma30.2NF1
43alzheimer's disease30.2GDNF
44breast cancer30.1VHL, CALCA, MEN1, PRKAR1A, NF1, CDKN1B
45somatostatinoma30.1CALCA, GAST, CHGA
46adenocarcinoma30.1VHL, GAST, MEN1, CHGA, CDKN1B
47glomus tumor30.1VHL, SDHD, SDHB
48hypertension30.1CALCA
49lipomatosis30.1MEN1
50meningioma30.1NF1, MEN1

Graphical network of the top 20 diseases related to Multiple Endocrine Neoplasia:



Diseases related to multiple endocrine neoplasia

Clinical Features for Multiple Endocrine Neoplasia

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Drugs & Therapeutics for Multiple Endocrine Neoplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Multiple Endocrine Neoplasia

Search CenterWatch for Multiple Endocrine Neoplasia

Genetic Tests for Multiple Endocrine Neoplasia

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Anatomical Context for Multiple Endocrine Neoplasia

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Animal Models for Multiple Endocrine Neoplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Multiple Endocrine Neoplasia:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.2NF1, CALCA, GNAS, GAST, MEN1, SDHD
2MP:000538511.1CDKN1B, CDC73, NF1, CHGA, PRKAR1A, GDNF
3MP:000537611.1CHGA, NF1, SDHD, PLCB3, RET, CDC73
4MP:000200611.0RET, CDKN1B, PRKAR1A, SDHD, NF1, MEN1
5MP:000536711.0VHL, CALCA, GNAS, CHGA, NF1, CDC73
6MP:000538711.0GAST, VHL, CDC73, CDKN1B, GDNF, NF1
7MP:000536911.0RET, GDNF, CDKN1B, GNAS, CDC73, VHL
8MP:000537911.0NF1, RET, GDNF, GAST, MEN1, CDKN1B
9MP:000537811.0GNAS, MEN1, PRKAR1A, NF1, VHL, SDHD
10MP:000538010.9MEN1, SDHD, PLCB3, RET, CDC73, CALCA
11MP:000538110.9CDKN1B, RET, GDNF, MEN1, CDC73, GAST
12MP:000539710.9PLCB3, RET, GDNF, CDKN1B, CDC73, NF1
13MP:000538410.9SDHD, RET, GDNF, NF1, VHL, GNAS
14MP:000538910.8CDC73, PRKAR1A, MEN1, VHL, CDKN1B, GDNF
15MP:000538810.8PRKAR1A, NF1, CDKN1B, GNAS
16MP:000538610.8SDHD, RET, PLCB3, GDNF, CALCA, CDKN1B
17MP:000363110.7SDHD, NF1, RET, GDNF, CDKN1B, CDC73
18MP:001077110.6CDKN1B, PLCB3, CALCA, GNAS, CDC73
19MP:000538210.5CDKN1B, NF1, PRKAR1A, MEN1, VHL, GNAS
20MP:000537010.3MEN1, GNAS, VHL, NF1, CDKN1B, CDC73

Publications for Multiple Endocrine Neoplasia

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Genetic Variations for Multiple Endocrine Neoplasia

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Expression for genes affiliated with Multiple Endocrine Neoplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Endocrine Neoplasia

Search GEO for disease gene expression data for Multiple Endocrine Neoplasia.

Pathways for genes affiliated with Multiple Endocrine Neoplasia

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Multiple Endocrine Neoplasia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.2VHL, CALCA, GNAS, GAST, MEN1, CHGA
2tyrosine4411.2RET, PLCB3, SDHB, GDNF, CDKN1B, NF1
3vegf4411.2RET, GDNF, SDHC, MEN1, CHGA, GAST
4cyclic amp44 2412.1PRKAR1A, RET, GDNF, CDKN1B, CNC, NF1
5serine4411.1CHGA, GNAS, RET, NF1, CDKN1B, GAST
6oxygen44 2412.1GNAS, CHGA, SDHC, CDKN1B, SDHB, SDHD
7succinate4411.1NF1, RET, SDHB, VHL, SDHC, SDHD
8adenylate4411.1GNAS, PRKAR1A, GDNF, CALCA, GAST, CHGA
9dopamine44 28 11 2414.1NF1, CHGA, SDHB, GAST, GDNF, GNAS
10oligonucleotide4411.0NF1, VHL, GNAS, CDKN1B, GDNF, CHGA
11norepinephrine44 11 2413.0CHGA, GAST, SDHB, GDNF, CALCA, GNAS
12arginine4411.0RET, SDHB, CDKN1B, GNAS, PRKAR1A, NF1
13alanine4411.0SDHB, CDKN1B, NF1, GAST, GNAS, GDNF
14catecholamine4411.0SDHB, CHGA, GDNF, RET, SDHD
15mibg4411.0CALCA, SDHB, CHGA, SDHD
16fumarate44 1112.0VHL, SDHD, SDHB, SDHC
17glutamate4411.0GDNF, GAST, PRKAR1A, GNAS
18forskolin44 49 1113.0PRKAR1A, GDNF, CALCA
19UBIQUINONE-11111.0SDHB, SDHD, SDHC
20cysteine4411.0CHGA, SDHB, RET, PRKAR1A, GDNF, NF1
21octreotide44 59 28 1114.0CALCA, CHGA, GAST, GNAS
22vitamin d4411.0CALCA, CHGA, PRKAR1A, MEN1, GAST
23histidine4411.0GAST, VHL, SDHB, GNAS, CHGA
24glucose4411.0SDHB, GDNF, CDKN1B, GAST
25testosterone44 59 11 2414.0CALCA, SDHB, RET, GAST, CDKN1B, CHGA
262-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.9SDHD, SDHB, SDHC
27l-amino acid4410.9GDNF, CHGA, PRKAR1A
28estrogen4410.9NF1
29succinic acid28 11 2412.9SDHC, SDHB, SDHD
30iron-sulfur4410.9SDHC, SDHB, SDHD
31bromodeoxyuridine4410.9GAST, CHGA, GDNF, CDKN1B
32ubiquinone4410.9SDHD, SDHC, SDHB
33iron44 2411.9SDHB, SDHD, SDHC, VHL, GDNF
34nitric oxide44 11 2412.9GNAS, VHL, CALCA, CHGA, GDNF, CDKN1B
35isoproterenol44 1111.9CALCA, GNAS, GAST, CHGA
36fluoride4410.9CHGA, CALCA, NF1
37acth4410.8GNAS, GAST, CALCA, CHGA
38calcium gluconate4410.8GAST, CALCA
39creatinine4410.8GDNF, SDHB, CHGA, CALCA, GAST
40lafutidine4410.8CALCA, GAST
41111in-pentetreotide4410.8CALCA, CHGA
42epinephrine44 11 2412.7CHGA, SDHB, CALCA, GAST
43azoxymethane4410.7CDKN1B, GAST
44propranolol44 28 49 11 2414.7CALCA, GAST, CHGA
45pepsinogen4410.6GAST, CHGA
46retinoic acid44 2411.6CHGA, GDNF, RET, SDHC, CDKN1B, NF1
47cinacalcet44 28 1112.6PRKAR1A, CALCA
48atp44 2811.5GDNF, CDKN1B, CHGA, RET, SDHB, NF1
49i-app4410.5GAST, CALCA
50methionine4410.3NF1, RET, CDKN1B, CHGA

GO Terms for genes affiliated with Multiple Endocrine Neoplasia

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16Gene Ontology
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Cellular components related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00574910.5SDHC, SDHB, SDHD

Biological processes related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00609910.5SDHC, SDHB, SDHD
2respiratory electron transport chainGO:02290410.5SDHC, SDHB, SDHD
3positive regulation of adenylate cyclase activityGO:04576210.4NF1, CALCA
4MAPK cascadeGO:00016510.3MEN1, NF1, RET

Molecular functions related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8CALCA, GNAS, GAST, MEN1, PRKAR1A, NF1
2ubiquinone bindingGO:04803910.2SDHB, SDHD

Products for genes affiliated with Multiple Endocrine Neoplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Endocrine Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet