MCID: MLT074
MIFTS: 53

Multiple Endocrine Neoplasia malady

Genetic diseases, Cancer diseases, Endocrine diseases, Rare diseases, Neuronal diseases, Gastrointestinal diseases, Fetal diseases categories

Summaries for Multiple Endocrine Neoplasia

About this section


Genetics Home Reference:21 Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.

MalaCards based summary: Multiple Endocrine Neoplasia, also known as multiple endocrine neoplasia type 1, is related to zollinger-ellison syndrome and gastrinoma. An important gene associated with Multiple Endocrine Neoplasia is MEN1 (multiple endocrine neoplasia I), and among its related pathways are G protein signaling H RAS regulation pathway and Signaling events regulated by Ret tyrosine kinase. The compounds 111in-pentetreotide and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Wikipedia:63 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

Aliases & Classifications for Multiple Endocrine Neoplasia

About this section

Multiple Endocrine Neoplasia, Aliases & Descriptions:

Name: Multiple Endocrine Neoplasia 21 43 60
Multiple Endocrine Neoplasia Type 1 60
Adenomatosis, Familial Endocrine 21
Multiple Endocrine Adenomatosis 21
Familial Endocrine Adenomatosis 21
 
Endocrine Neoplasia, Multiple 21
Multiple Endocrine Neoplasms 21
Mea 21
Men 21


Classifications:



Related Diseases for Multiple Endocrine Neoplasia

About this section

Diseases in the Multiple Endocrine Neoplasia family:

Multiple Endocrine Neoplasia, Type Iv Multiple Endocrine Neoplasia Iia
Multiple Endocrine Neoplasia Iib Multiple Endocrine Neoplasia 1

Diseases related to Multiple Endocrine Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.8MEN1, CHGA
2gastrinoma31.7CHGA, MEN1
3pheochromocytoma31.7SDHD, VHL, RET
4neuroendocrine tumor31.7CHGA, CALCA
5insulinoma31.5CALCA, MEN1, CHGA
6parathyroid carcinoma31.4RET, MEN1
7glucagonoma31.4CHGA, MEN1
8paraganglioma31.3CHGA, RET
9multiple endocrine neoplasia 131.3PRKAR1A, MEN1, CDKN1B, CHGA
10neuroma31.3GDNF, CALCA, RET
11cushing's syndrome31.3PRKAR1A
12vipoma31.2CALCA
13primary hyperparathyroidism31.1PRKAR1A, RET, CALCA, MEN1, CHGA
14ganglioneuroma31.1RET, CHGA
15malignant peripheral nerve sheath tumor31.0NF1
16lipomatosis31.0MEN1
17ependymoma30.9NF1, MEN1
18islet cell tumor30.9CALCA, RET, CHGA, MEN1
19medullary thyroid carcinoma, familial30.9GDNF, RET, CALCA
20thyroid cancer30.9GNAS, RET, CALCA, CDKN1B
21acromegaly30.8PRKAR1A, MEN1, GNAS
22renal dysplasia30.7GDNF, RET
23somatostatinoma30.7CHGA, CALCA
24glomus tumor30.6SDHD, VHL
25phaeochromocytoma30.6CALCA, SDHC, SDHD, RET, CHGA
26prolactinoma30.6MEN1, GNAS, CHGA, PRKAR1A
27hypercalcemia30.5PRKAR1A, CALCA, MEN1, CHGA
28peutz-jeghers syndrome30.5PRKAR1A, VHL
29neurofibromatosis, type 230.5NF1, SDHD
30adrenal adenoma30.5MEN1, GNAS, PRKAR1A
31pituitary tumors30.4CDKN1B, PRKAR1A, CHGA, GNAS, MEN1
32gastrointestinal stromal tumor30.3SDHC, NF1
33neurofibromatosis30.3NF1, VHL, SDHC, SDHD, RET
34von hippel-lindau syndrome30.3SDHD, MEN1, RET, SDHC, VHL, NF1
35hyperparathyroidism30.1CHGA, PRKAR1A, RET, MEN1, CALCA, NF1
36multiple endocrine neoplasia iia30.1NF1, CALCA, VHL, MEN1, RET, SDHC
37pituitary adenoma30.0MEN1, CDKN1B, PRKAR1A, CHGA, RET, GDNF
38adenocarcinoma30.0MEN1, VHL, CHGA, CDKN1B
39adenoma29.8GDNF, GNAS, CHGA, CALCA, CDKN1B, VHL
40breast cancer29.7NF1, PRKAR1A, CALCA, CDKN1B, MEN1, VHL
41hemangioma29.7VHL, MEN1, RET, SDHC, SDHD, NF1
42parathyroid adenoma29.7CHGA, GNAS, PRKAR1A, RET, CDKN1B, CALCA
43carcinoid syndrome29.6CHGA, CALCA, SDHD, GNAS, MEN1, RET
44adrenal cortical adenoma29.5CHGA, VHL, MEN1, PRKAR1A, SDHC, SDHD
45thyroiditis11.1
46pancreatitis11.0
47multiple endocrine neoplasia iib10.8
48amyloidosis10.7
49multiple endocrine neoplasia, type iv10.6
50duodenitis10.6

Graphical network of the top 20 diseases related to Multiple Endocrine Neoplasia:



Diseases related to multiple endocrine neoplasia

Symptoms for Multiple Endocrine Neoplasia

About this section

Drugs & Therapeutics for Multiple Endocrine Neoplasia

About this section

Drug clinical trials:

Search ClinicalTrials for Multiple Endocrine Neoplasia

Search NIH Clinical Center for Multiple Endocrine Neoplasia

Genetic Tests for Multiple Endocrine Neoplasia

About this section

Anatomical Context for Multiple Endocrine Neoplasia

About this section

MalaCards organs/tissues related to Multiple Endocrine Neoplasia:

31
Thyroid, Pituitary, Testes, Bone, Pancreas, Skin, Pancreatic islet, Brain, Colon, Kidney, Liver, Adrenal gland, Breast, Prostate, Tongue, Lymph node, Thymus, Spinal cord, Adipocyte, Lung, Ovary, Endothelial

Animal Models for Multiple Endocrine Neoplasia or affiliated genes

About this section

MGI Mouse Phenotypes related to Multiple Endocrine Neoplasia:

35 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7NF1, VHL, RET, GNAS
2MP:00053778.6CDKN1B, NF1, CALCA, GNAS
3MP:00053818.5GDNF, PRKAR1A, RET, MEN1, VHL, CDKN1B
4MP:00053708.5GNAS, MEN1, VHL, NF1, CDKN1B
5MP:00053898.2GDNF, CHGA, PRKAR1A, RET, MEN1, VHL
6MP:00053828.2GNAS, PRKAR1A, MEN1, VHL, NF1, CDKN1B
7MP:00053808.0SDHD, PRKAR1A, RET, MEN1, VHL, CALCA
8MP:00053888.0GNAS, PRKAR1A, RET, CALCA, NF1, CDKN1B
9MP:00107718.0GNAS, VHL, CALCA, NF1, CDKN1B
10MP:00053908.0GNAS, PRKAR1A, VHL, CALCA, NF1
11MP:00020067.8SDHD, PRKAR1A, RET, MEN1, VHL, CALCA
12MP:00053977.6GDNF, GNAS, PRKAR1A, RET, VHL, NF1
13MP:00053677.5GDNF, GNAS, CHGA, RET, VHL, CALCA
14MP:00053697.5GDNF, GNAS, PRKAR1A, RET, MEN1, VHL
15MP:00028737.5GNAS, SDHD, PRKAR1A, RET, VHL, CALCA
16MP:00053877.4GDNF, GNAS, PRKAR1A, RET, MEN1, VHL
17MP:00053867.4GDNF, GNAS, SDHD, RET, CALCA, NF1
18MP:00036317.2GDNF, GNAS, SDHD, RET, MEN1, CALCA
19MP:00053846.8GDNF, GNAS, SDHD, PRKAR1A, RET, MEN1
20MP:00053766.5PRKAR1A, CHGA, SDHD, GNAS, RET, MEN1
21MP:00053796.5CHGA, SDHD, GNAS, GDNF, PRKAR1A, RET
22MP:00053786.4GDNF, GNAS, SDHD, CHGA, PRKAR1A, RET
23MP:00053856.1CDKN1B, GDNF, GNAS, SDHD, CHGA, PRKAR1A
24MP:00107685.6CHGA, SDHC, SDHD, GNAS, GDNF, PRKAR1A

Publications for Multiple Endocrine Neoplasia

About this section

Articles related to Multiple Endocrine Neoplasia:

(show top 50)    (show all 1037)
idTitleAuthorsYear
1
Molecular diagnosis and comprehensive treatment of multiple endocrine neoplasia type 2 in Southeastern Chinese. (25628771)
2015
2
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. (23562332)
2013
3
Multiple endocrine neoplasia: the enigma of MEN. (23880753)
2013
4
A novel germline mutation of the MEN1 gene caused multiple endocrine neoplasia type 1 in a Chinese young man and 1 year follow-up. (24302194)
2013
5
A novel menin gene deletional mutation in a little series of Italian patients affected by apparently sporadic multiple endocrine neoplasia type 1 syndrome. (22490989)
2012
6
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
7
Novel association of thymic carcinoid with a germline mutation in a kindred with multiple endocrine neoplasia 1 (MEN1). (22549346)
2012
8
Coexistence of Multiple Endocrine Neoplasia Type 2B and Chilaiditi Sign: A Case Report. (23119190)
2012
9
Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association? (23259638)
2012
10
Neural hyperplasia in maxillary bone of multiple endocrine neoplasia type 2B patient. (22099857)
2011
11
A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma. (21069576)
2011
12
Intracranial ependymoma associated with multiple endocrine neoplasia type 1. (20142633)
2010
13
Pathogenicity of DNA variants and double mutations in multiple endocrine neoplasia type 2 and von Hippel-Lindau syndrome. (19906784)
2010
14
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. (20555035)
2010
15
Unusual features of medullary thyroid carcinoma in multiple endocrine neoplasia type 2A. (19332941)
2009
16
Multiple endocrine neoplasia type 2a and germ line C634G RET mutation diagnosed in an 80-year-old patient. (19201392)
2009
17
First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome. (19034701)
2008
18
Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians. (19169500)
2008
19
Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. (17235589)
2007
20
The impact of clinical and genetic screenings on the management of the multiple endocrine neoplasia type 1. (17823710)
2007
21
Management of nonfunctioning pancreatic endocrine tumors in the context of multiple endocrine neoplasia type 1 syndrome. (17925918)
2007
22
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. (16680581)
2006
23
Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. (15714081)
2005
24
Do all patients with RET mutations associated with multiple endocrine neoplasia type 2 require surgery? (16929368)
2005
25
Adrenal ganglioneuromas in children with multiple endocrine neoplasia type 2: a report of two cases. (15827098)
2005
26
Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. (15254225)
2004
27
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. (12941803)
2003
28
Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism. (12699448)
2003
29
Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1. (12050235)
2002
30
Multiple endocrine neoplasia. (11786689)
2001
31
A false-positive diagnosis of C-cell hyperplasia in a member of a family with multiple endocrine neoplasia type 2A and familial colonic polyposis. (9591014)
1998
32
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
33
The molecular genetics of multiple endocrine neoplasia type 2A and related syndromes. (9046972)
1997
34
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1. (9003510)
1997
35
Mutation of RET proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. (9447290)
1997
36
A family of multiple endocrine neoplasia type 2A: genetic analysis and clinical features. (8732448)
1996
37
Diagnosis and management of pheochromocytomas in patients with multiple endocrine neoplasia type 2-relevance of specific mutations in the RET proto-oncogene. (8810737)
1996
38
Prophylactic surgery for multiple endocrine neoplasia type IIa after genetic diagnosis: is parathyroid transplantation indicated? (8678956)
1996
39
Cutaneous macular amyloidosis associated with multiple endocrine neoplasia 2A. (8959910)
1996
40
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
41
Multiple endocrine neoplasia]. (7752481)
1995
42
Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas. (8600671)
1995
43
Candidate genes for multiple endocrine neoplasia type 1. (7673854)
1995
44
Germ line mutation in the RET proto-oncogene associated with familial multiple endocrine neoplasia type 2B: a case report. (7596047)
1995
45
A metastatic neuroendocrine anaplastic small cell tumor in a patient with multiple endocrine neoplasia type 1 syndrome. Assessment of disease status and response to doxorubicin, cyclophosphamide, etoposide chemotherapy through scintigraphic imaging with 111In-pentetreotide. (7922988)
1994
46
A cluster of CpG islands at D10S94, near the locus responsible for multiple endocrine neoplasia type 2A (MEN2A). (1351867)
1992
47
Influence of multiple endocrine neoplasia type 1 on gastric endocrine cells in patients with the Zollinger-Ellison syndrome. (1358767)
1992
48
Pathological features of multiple endocrine neoplasia type IIb in childhood. (1973536)
1990
49
Search for the gene for multiple endocrine neoplasia type 2A. (2281187)
1990
50
Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region. (2873080)
1986

Variations for Multiple Endocrine Neoplasia

About this section

Clinvar genetic disease variations for Multiple Endocrine Neoplasia:

6 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1MEN1NM_000244.3(MEN1): c.65T> G (p.Leu22Arg)single nucleotide variantPathogenicrs104894256GRCh37Chr 11, 64577517: 64577517
2MEN1NM_000244.3(MEN1): c.402delC (p.Phe134Leufs)deletionPathogenicrs397515385GRCh37Chr 11, 64577180: 64577180
3MEN1NM_000244.3(MEN1): c.608G> A (p.Trp203Ter)single nucleotide variantPathogenicrs104894258GRCh37Chr 11, 64575424: 64575424
4MEN1NM_000244.3(MEN1): c.1321T> A (p.Trp441Arg)single nucleotide variantPathogenicrs104894259GRCh37Chr 11, 64572550: 64572550
5MEN1NM_000244.3(MEN1): c.1322G> A (p.Trp441Ter)single nucleotide variantPathogenicrs104894260GRCh37Chr 11, 64572549: 64572549
6MEN1NM_000244.3(MEN1): c.1594C> T (p.Arg532Ter)single nucleotide variantPathogenicrs104894261GRCh37Chr 11, 64572060: 64572060
7MEN1NM_000244.3(MEN1): c.793C> T (p.Gln265Ter)single nucleotide variantPathogenicrs104894266GRCh37Chr 11, 64575029: 64575029
8MEN1NM_000244.3(MEN1): c.1393C> T (p.Arg465Ter)single nucleotide variantPathogenicrs104894267GRCh37Chr 11, 64572261: 64572261
9MEN1NM_000244.3(MEN1): c.415C> G (p.His139Asp)single nucleotide variantPathogenicrs104894263GRCh37Chr 11, 64577167: 64577167
10MEN1NM_000244.3(MEN1): c.1267G> A (p.Asp423Asn)single nucleotide variantPathogenicrs104894264GRCh37Chr 11, 64572604: 64572604
11MEN1NM_000244.3(MEN1): c.1077C> A (p.Cys359Ter)single nucleotide variantPathogenicrs104894265GRCh37Chr 11, 64573230: 64573230
12MEN1NM_000244.3(MEN1): c.211_212delCC (p.Pro71Alafs)deletionPathogenicrs386134251GRCh37Chr 11, 64577370: 64577371
13MEN1NM_000244.3(MEN1): c.518T> C (p.Leu173Pro)single nucleotide variantPathogenicrs386134256GRCh37Chr 11, 64575514: 64575514

Expression for genes affiliated with Multiple Endocrine Neoplasia

About this section
Search GEO for disease gene expression data for Multiple Endocrine Neoplasia.

Pathways for genes affiliated with Multiple Endocrine Neoplasia

About this section

Pathways related to Multiple Endocrine Neoplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GDNF, RET
29.7GDNF, RET
39.3VHL, PRKAR1A, RET
49.3GNAS, CALCA
59.1GNAS, PRKAR1A
69.1PRKAR1A, GNAS
7
Show member pathways
8.8GNAS, PRKAR1A, CDKN1B
8
Show member pathways
Calcium Regulation in the Cardiac Cell36
8.8GNAS, CALCA, PRKAR1A
9
Show member pathways
8.2CDKN1B, CALCA, MEN1, PRKAR1A, GNAS

Compounds for genes affiliated with Multiple Endocrine Neoplasia

About this section

Compounds related to Multiple Endocrine Neoplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide4310.0CHGA, CALCA
2sunitinib43 49 1211.9VHL, RET
3cinacalcet43 28 1211.9PRKAR1A, CALCA
4fluoride439.7NF1, CALCA, CHGA
5Fumaric acid249.6SDHC, SDHD
61,25 dihydroxy vitamin d3439.6CDKN1B, CALCA, GDNF
7bromodeoxyuridine439.6GDNF, CHGA, CDKN1B
8methionine439.5CHGA, RET, NF1, CDKN1B
9mibg439.5SDHD, CHGA, CALCA
10l-amino acid439.5GDNF, CHGA, PRKAR1A
11paraffin439.5CDKN1B, NF1, RET, CHGA
12ly294002439.5CDKN1B, VHL, RET, GDNF
13fumarate43 1210.4SDHD, SDHC, VHL
14acth439.4GNAS, CHGA
15ubiquinone439.3SDHC, SDHD
16vitamin d439.3CHGA, PRKAR1A, MEN1, CALCA
17testosterone43 59 24 1212.3CDKN1B, CALCA, RET, CHGA
18octreotide43 59 28 1212.2CALCA, CHGA, GNAS
19iron-sulfur439.2SDHC, SDHD
20catecholamine439.1RET, CHGA, SDHD, GDNF
21phosphatidylinositol439.1GDNF, RET, VHL, NF1, CDKN1B
22isoproterenol43 1210.1CALCA, CHGA, GNAS
23succinic acid28 24 1211.0SDHC, SDHD
24guanine43 24 1211.0GNAS, CHGA, CALCA
25atp43 289.9CDKN1B, NF1, RET, CHGA, GDNF
26iron43 249.8GDNF, SDHD, SDHC, VHL
27succinate438.8SDHD, SDHC, RET, VHL, NF1
28progesterone43 28 59 24 1212.8CDKN1B, NF1, CHGA, GNAS
29dexamethasone43 49 28 1211.8GDNF, CHGA, PRKAR1A, CDKN1B
30norepinephrine43 24 1210.8CALCA, CHGA, GNAS, GDNF
31alanine438.6GDNF, GNAS, RET, NF1, CDKN1B
32retinoic acid43 249.6GDNF, SDHC, CHGA, RET, NF1, CDKN1B
33estrogen438.4GDNF, CHGA, MEN1, VHL, CALCA, NF1
34lipid438.4GDNF, GNAS, CHGA, RET, NF1
35steroid438.2GNAS, SDHC, CHGA, PRKAR1A, NF1
36dopamine43 28 24 1211.2GDNF, GNAS, CHGA, RET, CALCA, NF1
37arginine438.2GNAS, CHGA, PRKAR1A, RET, NF1, CDKN1B
38nitric oxide43 24 1210.2GDNF, GNAS, CHGA, VHL, CALCA, CDKN1B
39glucose438.0GDNF, GNAS, CHGA, PRKAR1A, VHL, CDKN1B
40cysteine438.0GDNF, GNAS, CHGA, PRKAR1A, RET, NF1
41glutamate438.0GDNF, GNAS, CHGA, PRKAR1A, CALCA, CDKN1B
42vegf438.0GDNF, SDHC, CHGA, RET, MEN1, VHL
43oligonucleotide438.0GDNF, GNAS, CHGA, RET, VHL, NF1
44adenylate438.0GDNF, GNAS, CHGA, PRKAR1A, CALCA, NF1
45serine437.7GDNF, GNAS, CHGA, RET, MEN1, VHL
46forskolin43 49 129.7GDNF, GNAS, CHGA, PRKAR1A, CALCA, NF1
47tyrosine437.7GDNF, GNAS, CHGA, RET, MEN1, VHL
48oxygen43 248.5GDNF, GNAS, SDHD, SDHC, CHGA, VHL
49cyclic amp43 248.4CDKN1B, GDNF, GNAS, CHGA, PRKAR1A, RET
50calcium43 49 24 1210.1GDNF, GNAS, CHGA, PRKAR1A, RET, MEN1

GO Terms for genes affiliated with Multiple Endocrine Neoplasia

About this section

Cellular components related to Multiple Endocrine Neoplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.4CDKN1B, MEN1, PRKAR1A
2mitochondrial respiratory chain complex IIGO:00057499.0SDHC, SDHD

Biological processes related to Multiple Endocrine Neoplasia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.2CDKN1B, MEN1
2positive regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200124110.2RET, NF1
3response to painGO:004826510.1CALCA, RET
4positive regulation of adenylate cyclase activityGO:004576210.1NF1, CALCA
5negative regulation of osteoclast differentiationGO:004567110.0CALCA, NF1
6enteric nervous system developmentGO:004848410.0GDNF, RET
7MAPK cascadeGO:00001659.9NF1, MEN1, RET
8sympathetic nervous system developmentGO:00484859.9GDNF, NF1
9metanephros developmentGO:00016569.9NF1, GDNF
10neural crest cell migrationGO:00017559.7RET, GDNF
11positive regulation of Ras GTPase activityGO:00323209.6NF1, GNAS
12cognitionGO:00508909.5NF1, GNAS
13tricarboxylic acid cycleGO:00060999.5SDHC, SDHD
14activation of adenylate cyclase activityGO:00071909.4CALCA, GNAS
15positive regulation of cAMP biosynthetic processGO:00308199.3GNAS, CALCA
16cellular response to glucagon stimulusGO:00713779.2GNAS, PRKAR1A
17adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.2GNAS, CALCA
18response to drugGO:00424939.1CDKN1B, RET, GNAS
19water transportGO:00068338.8GNAS, PRKAR1A

Molecular functions related to Multiple Endocrine Neoplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase activityGO:00001049.0SDHC, SDHD
2protein bindingGO:00055157.2PRKAR1A, RET, MEN1, VHL, CALCA, NF1

Products for genes affiliated with Multiple Endocrine Neoplasia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Multiple Endocrine Neoplasia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet