MEA
MCID: MLT074
MIFTS: 61

Multiple Endocrine Neoplasia (MEA) malady

Genetic diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases, Endocrine diseases categories
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Summaries for Multiple Endocrine Neoplasia

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Genetics Home Reference:21 Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.

MalaCards based summary: Multiple Endocrine Neoplasia, also known as adenomatosis, familial endocrine, is related to zollinger-ellison syndrome and gastrinoma. An important gene associated with Multiple Endocrine Neoplasia is RET (ret proto-oncogene), and among its related pathways are G protein signaling H RAS regulation pathway and Signaling events regulated by Ret tyrosine kinase. The compounds 111in-pentetreotide and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Wikipedia:65 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

Aliases & Classifications for Multiple Endocrine Neoplasia

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Multiple Endocrine Neoplasia, Aliases & Descriptions:

Name: Multiple Endocrine Neoplasia 21 44 62
Adenomatosis, Familial Endocrine 21 62
Endocrine Adenomatosis, Multiple 62
Familial Endocrine Adenomatosis 21
Multiple Endocrine Adenomatosis 21
 
Endocrine Neoplasia, Multiple 21
Multiple Endocrine Neoplasms 21
Men 21
Mea 21


Classifications:



Related Diseases for Multiple Endocrine Neoplasia

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Diseases in the Multiple Endocrine Neoplasia Type 2a family:

Multiple Endocrine Neoplasia Type 4 multiple endocrine neoplasia

Diseases related to Multiple Endocrine Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1zollinger-ellison syndrome31.8MEN1, CHGA
2gastrinoma31.7MEN1, CHGA
3pheochromocytoma31.7VHL, RET, SDHD
4neuroendocrine tumor31.6CHGA, CALCA
5familial medullary thyroid carcinoma31.6GDNF, RET, CALCA
6insulinoma31.5CALCA, MEN1, CHGA
7hirschsprung's disease31.4GDNF, RET
8glucagonoma31.4CHGA, MEN1
9parathyroid carcinoma31.4RET, MEN1
10neuroma31.3GDNF, RET, CALCA
11cushing's syndrome31.3PRKAR1A
12papillary thyroid carcinoma31.2CALCA, MEN1, RET
13paraganglioma31.2VHL, SDHD
14primary hyperparathyroidism31.1CHGA, PRKAR1A, RET, MEN1, CALCA
15wermer syndrome31.1CHGA, PRKAR1A, MEN1, CDKN1B
16ganglioneuroma31.1CHGA, RET
17vipoma31.0MEN1, CHGA
18lipomatosis31.0MEN1
19neurofibromatosis31.0SDHD, NF1
20multiple endocrine neoplasia type 2a30.9GDNF, SDHD, SDHC, NF1, CALCA, VHL
21ependymoma30.9NF1, MEN1
22neuroendocrine carcinoma30.9CHGA, MEN1, CALCA
23pancreatic islet cell tumors30.8CHGA, RET, MEN1, CALCA
24acromegaly30.7MEN1, PRKAR1A, GNAS
25renal dysplasia30.7GDNF, RET
26somatostatinoma30.7CALCA, CHGA
27prolactinoma30.6GNAS, CHGA, PRKAR1A, MEN1
28phaeochromocytoma30.6SDHD, SDHC, CHGA, RET, CALCA
29hypercalcemia30.6CHGA, PRKAR1A, MEN1, CALCA
30peutz-jeghers syndrome30.5VHL, PRKAR1A
31adrenal adenoma30.5MEN1, PRKAR1A, GNAS
32pituitary tumors30.4GNAS, CHGA, PRKAR1A, MEN1, CDKN1B
33von hippel-lindau disease30.4NF1, VHL, MEN1, RET, SDHC, SDHD
34gastrointestinal stromal tumor30.3NF1, SDHC
35carney complex30.3GNAS, PRKAR1A, MEN1, CDKN1B
36hyperparathyroidism30.2RET, PRKAR1A, CHGA, SDHC, SDHD, MEN1
37thyroid medullary carcinoma30.1CALCA, VHL, MEN1, RET, PRKAR1A, CHGA
38pituitary adenoma30.0MEN1, RET, PRKAR1A, CHGA, GNAS, GDNF
39adenocarcinoma30.0CHGA, MEN1, VHL, CDKN1B
40adenoma29.8GDNF, CDKN1B, CALCA, VHL, MEN1, RET
41breast cancer29.7CDKN1B, NF1, CALCA, VHL, MEN1, PRKAR1A
42hemangioma29.7SDHD, SDHC, RET, MEN1, VHL, NF1
43parathyroid adenoma29.7CDKN1B, CALCA, MEN1, RET, PRKAR1A, CHGA
44carcinoid syndrome29.7GNAS, SDHD, CHGA, RET, MEN1, CALCA
45adrenal cortical adenoma29.5SDHD, SDHC, CHGA, PRKAR1A, MEN1, VHL
46thyroiditis11.1
47pancreatitis11.0
48wagenmann-froboese syndrome10.7
49amyloidosis10.7
50lichen amyloidosis10.7

Graphical network of the top 20 diseases related to Multiple Endocrine Neoplasia:



Diseases related to multiple endocrine neoplasia

Symptoms for Multiple Endocrine Neoplasia

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Drugs & Therapeutics for Multiple Endocrine Neoplasia

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Drug clinical trials:

Search ClinicalTrials for Multiple Endocrine Neoplasia

Search NIH Clinical Center for Multiple Endocrine Neoplasia

Genetic Tests for Multiple Endocrine Neoplasia

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Anatomical Context for Multiple Endocrine Neoplasia

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MalaCards organs/tissues related to Multiple Endocrine Neoplasia:

32
Thyroid, Pituitary, Testes, Bone, Pancreas, Skin, Pancreatic islet, Brain, Colon, Kidney, Liver, Adrenal gland, Breast, Prostate, Tongue, Lymph node, Thymus, Spinal cord, Adipocyte, Lung, Ovary, Endothelial

Animal Models for Multiple Endocrine Neoplasia or affiliated genes

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MGI Mouse Phenotypes related to Multiple Endocrine Neoplasia:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7RET, GNAS, VHL, NF1
2MP:00053778.6CDKN1B, NF1, CALCA, GNAS
3MP:00053818.5CDKN1B, VHL, MEN1, RET, PRKAR1A, GDNF
4MP:00053708.5NF1, GNAS, CDKN1B, MEN1, VHL
5MP:00053898.2RET, GDNF, CHGA, PRKAR1A, CDKN1B, MEN1
6MP:00053828.1PRKAR1A, MEN1, VHL, NF1, CDKN1B, GNAS
7MP:00053888.0NF1, CDKN1B, CALCA, RET, PRKAR1A, GNAS
8MP:00053808.0CALCA, VHL, MEN1, SDHD, PRKAR1A, RET
9MP:00107718.0VHL, CALCA, GNAS, CDKN1B, NF1
10MP:00053908.0NF1, VHL, PRKAR1A, GNAS, CALCA
11MP:00020067.8NF1, CDKN1B, CALCA, VHL, MEN1, RET
12MP:00053977.6RET, VHL, NF1, CDKN1B, GNAS, GDNF
13MP:00053677.5VHL, GNAS, NF1, GDNF, RET, CALCA
14MP:00053697.5VHL, MEN1, GNAS, RET, NF1, CDKN1B
15MP:00028737.5PRKAR1A, RET, VHL, GNAS, NF1, SDHD
16MP:00053877.4CDKN1B, NF1, GDNF, GNAS, PRKAR1A, RET
17MP:00053867.4RET, SDHD, GNAS, GDNF, NF1, CALCA
18MP:00036317.2CDKN1B, NF1, CALCA, MEN1, SDHD, GNAS
19MP:00053846.8SDHD, VHL, CDKN1B, NF1, MEN1, RET
20MP:00053766.5MEN1, CDKN1B, NF1, CALCA, RET, PRKAR1A
21MP:00053796.5VHL, MEN1, RET, PRKAR1A, SDHD, GNAS
22MP:00053786.4GNAS, SDHD, CHGA, PRKAR1A, RET, MEN1
23MP:00053856.1GDNF, NF1, CDKN1B, CALCA, VHL, MEN1
24MP:00107685.6PRKAR1A, GDNF, MEN1, CDKN1B, NF1, CALCA

Publications for Multiple Endocrine Neoplasia

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Articles related to Multiple Endocrine Neoplasia:

(show top 50)    (show all 1011)
idTitleAuthorsYear
1
Anaesthetic management of a dopamine-secreting phaeochromocytoma in multiple endocrine neoplasia 2B syndrome. (24963196)
2014
2
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. (23562332)
2013
3
Multiple endocrine neoplasia: the enigma of MEN. (23880753)
2013
4
A novel germline mutation of the MEN1 gene caused multiple endocrine neoplasia type 1 in a Chinese young man and 1 year follow-up. (24302194)
2013
5
A novel menin gene deletional mutation in a little series of Italian patients affected by apparently sporadic multiple endocrine neoplasia type 1 syndrome. (22490989)
2012
6
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
7
Novel association of thymic carcinoid with a germline mutation in a kindred with multiple endocrine neoplasia 1 (MEN1). (22549346)
2012
8
Coexistence of Multiple Endocrine Neoplasia Type 2B and Chilaiditi Sign: A Case Report. (23119190)
2012
9
Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association? (23259638)
2012
10
Neural hyperplasia in maxillary bone of multiple endocrine neoplasia type 2B patient. (22099857)
2011
11
A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma. (21069576)
2011
12
Intracranial ependymoma associated with multiple endocrine neoplasia type 1. (20142633)
2010
13
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. (20555035)
2010
14
Unusual features of medullary thyroid carcinoma in multiple endocrine neoplasia type 2A. (19332941)
2009
15
Multiple endocrine neoplasia type 2a and germ line C634G RET mutation diagnosed in an 80-year-old patient. (19201392)
2009
16
First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome. (19034701)
2008
17
Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians. (19169500)
2008
18
Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. (17235589)
2007
19
The impact of clinical and genetic screenings on the management of the multiple endocrine neoplasia type 1. (17823710)
2007
20
Management of nonfunctioning pancreatic endocrine tumors in the context of multiple endocrine neoplasia type 1 syndrome. (17925918)
2007
21
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. (16680581)
2006
22
Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. (15714081)
2005
23
Do all patients with RET mutations associated with multiple endocrine neoplasia type 2 require surgery? (16929368)
2005
24
Adrenal ganglioneuromas in children with multiple endocrine neoplasia type 2: a report of two cases. (15827098)
2005
25
Heterotropic cardiac calcification: a rare presentation of multiple endocrine neoplasia. (16324211)
2005
26
Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. (15254225)
2004
27
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. (12941803)
2003
28
Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism. (12699448)
2003
29
Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1. (12050235)
2002
30
Multiple endocrine neoplasia. (11786689)
2001
31
A false-positive diagnosis of C-cell hyperplasia in a member of a family with multiple endocrine neoplasia type 2A and familial colonic polyposis. (9591014)
1998
32
Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? (9777749)
1998
33
The molecular genetics of multiple endocrine neoplasia type 2A and related syndromes. (9046972)
1997
34
Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1. (9003510)
1997
35
Mutation of RET proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. (9447290)
1997
36
A family of multiple endocrine neoplasia type 2A: genetic analysis and clinical features. (8732448)
1996
37
Diagnosis and management of pheochromocytomas in patients with multiple endocrine neoplasia type 2-relevance of specific mutations in the RET proto-oncogene. (8810737)
1996
38
Prophylactic surgery for multiple endocrine neoplasia type IIa after genetic diagnosis: is parathyroid transplantation indicated? (8678956)
1996
39
Cutaneous macular amyloidosis associated with multiple endocrine neoplasia 2A. (8959910)
1996
40
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
41
Multiple endocrine neoplasia]. (7752481)
1995
42
Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas. (8600671)
1995
43
Candidate genes for multiple endocrine neoplasia type 1. (7673854)
1995
44
Germ line mutation in the RET proto-oncogene associated with familial multiple endocrine neoplasia type 2B: a case report. (7596047)
1995
45
A metastatic neuroendocrine anaplastic small cell tumor in a patient with multiple endocrine neoplasia type 1 syndrome. Assessment of disease status and response to doxorubicin, cyclophosphamide, etoposide chemotherapy through scintigraphic imaging with 111In-pentetreotide. (7922988)
1994
46
A cluster of CpG islands at D10S94, near the locus responsible for multiple endocrine neoplasia type 2A (MEN2A). (1351867)
1992
47
Influence of multiple endocrine neoplasia type 1 on gastric endocrine cells in patients with the Zollinger-Ellison syndrome. (1358767)
1992
48
Pathological features of multiple endocrine neoplasia type IIb in childhood. (1973536)
1990
49
Search for the gene for multiple endocrine neoplasia type 2A. (2281187)
1990
50
Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region. (2873080)
1986

Variations for Multiple Endocrine Neoplasia

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Expression for genes affiliated with Multiple Endocrine Neoplasia

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Expression patterns in normal tissues for genes affiliated with Multiple Endocrine Neoplasia

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Pathways for genes affiliated with Multiple Endocrine Neoplasia

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Pathways related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8GDNF, RET
29.8GDNF, RET
39.4VHL, PRKAR1A, RET
49.3GNAS, CALCA
59.3GNAS, CALCA
69.1GNAS, PRKAR1A
79.1PRKAR1A, GNAS
8
Show member pathways
8.8GNAS, PRKAR1A, CDKN1B
9
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.8GNAS, CALCA, PRKAR1A
10
Show member pathways
8.2CDKN1B, CALCA, MEN1, PRKAR1A, GNAS

Compounds for genes affiliated with Multiple Endocrine Neoplasia

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Compounds related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide4410.0CHGA, CALCA
2sunitinib44 50 1112.0RET, VHL
3cinacalcet44 28 1111.9PRKAR1A, CALCA
4fluoride449.7CALCA, CHGA, NF1
5Fumaric acid249.6SDHC, SDHD
61,25 dihydroxy vitamin d3449.6GDNF, CDKN1B, CALCA
7bromodeoxyuridine449.6CDKN1B, GDNF, CHGA
8methionine449.5CDKN1B, NF1, RET, CHGA
9mibg449.5CHGA, CALCA, SDHD
10l-amino acid449.5CHGA, GDNF, PRKAR1A
11paraffin449.5NF1, RET, CHGA, CDKN1B
12ly294002449.5CDKN1B, VHL, RET, GDNF
13fumarate44 1110.4SDHC, VHL, SDHD
14acth449.4CHGA, GNAS
15ubiquinone449.3SDHC, SDHD
16testosterone44 61 24 1112.3CDKN1B, CALCA, RET, CHGA
17vitamin d449.2CHGA, PRKAR1A, MEN1, CALCA
18octreotide44 61 28 1112.2CALCA, CHGA, GNAS
19iron-sulfur449.2SDHD, SDHC
20catecholamine449.1RET, CHGA, SDHD, GDNF
21phosphatidylinositol449.1GDNF, CDKN1B, NF1, VHL, RET
22isoproterenol44 1110.1CHGA, GNAS, CALCA
23succinic acid28 24 1111.0SDHC, SDHD
24guanine44 24 1111.0CALCA, CHGA, GNAS
25atp44 2810.0CHGA, GDNF, RET, NF1, CDKN1B
26succinate448.8RET, SDHC, NF1, SDHD, VHL
27iron44 249.8GDNF, SDHC, VHL, SDHD
28progesterone44 28 61 24 1112.8CHGA, CDKN1B, NF1, GNAS
29dexamethasone44 50 28 1111.8CHGA, PRKAR1A, GDNF, CDKN1B
30norepinephrine44 24 1110.8GDNF, CALCA, CHGA, GNAS
31alanine448.6GDNF, RET, NF1, GNAS, CDKN1B
32retinoic acid44 249.6RET, NF1, CDKN1B, SDHC, GDNF, CHGA
33estrogen448.4MEN1, VHL, CALCA, NF1, CDKN1B, GDNF
34lipid448.4RET, GNAS, GDNF, CHGA, NF1
35dopamine44 28 24 1111.2GDNF, GNAS, CHGA, NF1, CALCA, RET
36steroid448.2PRKAR1A, NF1, CHGA, SDHC, GNAS
37arginine448.2CDKN1B, CHGA, PRKAR1A, RET, NF1, GNAS
38nitric oxide44 24 1110.2VHL, CHGA, GNAS, CALCA, CDKN1B, GDNF
39cysteine448.0PRKAR1A, CHGA, RET, GNAS, NF1, GDNF
40glucose448.0CHGA, CDKN1B, VHL, PRKAR1A, GNAS, GDNF
41oligonucleotide448.0CDKN1B, CHGA, NF1, VHL, RET, GDNF
42glutamate448.0CALCA, CDKN1B, PRKAR1A, CHGA, GNAS, GDNF
43vegf448.0CDKN1B, CALCA, VHL, MEN1, RET, CHGA
44adenylate448.0PRKAR1A, CHGA, GDNF, GNAS, CALCA, NF1
45serine447.7GDNF, GNAS, RET, CDKN1B, NF1, VHL
46forskolin44 50 119.7GDNF, GNAS, CHGA, CALCA, PRKAR1A, CDKN1B
47tyrosine447.7RET, CDKN1B, CHGA, MEN1, GNAS, NF1
48oxygen44 248.5CDKN1B, VHL, CHGA, SDHC, SDHD, GDNF
49cyclic amp44 248.4RET, NF1, PRKAR1A, CHGA, CDKN1B, GNAS
50calcium44 50 24 1110.1NF1, CALCA, VHL, MEN1, RET, PRKAR1A

GO Terms for genes affiliated with Multiple Endocrine Neoplasia

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Cellular components related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.4CDKN1B, MEN1, PRKAR1A
2mitochondrial respiratory chain complex IIGO:0057499.0SDHC, SDHD

Biological processes related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124110.2NF1, RET
2negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:04573610.2CDKN1B, MEN1
3response to painGO:04826510.1RET, CALCA
4positive regulation of adenylate cyclase activityGO:04576210.1CALCA, NF1
5negative regulation of osteoclast differentiationGO:04567110.0CALCA, NF1
6enteric nervous system developmentGO:04848410.0RET, GDNF
7MAPK cascadeGO:0001659.9NF1, MEN1, RET
8sympathetic nervous system developmentGO:0484859.9GDNF, NF1
9metanephros developmentGO:0016569.9NF1, GDNF
10neural crest cell migrationGO:0017559.8RET, GDNF
11positive regulation of Ras GTPase activityGO:0323209.6GNAS, NF1
12cognitionGO:0508909.5GNAS, NF1
13tricarboxylic acid cycleGO:0060999.5SDHC, SDHD
14activation of adenylate cyclase activityGO:0071909.4GNAS, CALCA
15positive regulation of cAMP biosynthetic processGO:0308199.3CALCA, GNAS
16cellular response to glucagon stimulusGO:0713779.2GNAS, PRKAR1A
17adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.2CALCA, GNAS
18response to drugGO:0424939.1GNAS, CDKN1B, RET
19water transportGO:0068338.8GNAS, PRKAR1A

Molecular functions related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase activityGO:0001049.0SDHC, SDHD
2protein bindingGO:0055157.2PRKAR1A, RET, MEN1, VHL, CALCA, NF1

Products for genes affiliated with Multiple Endocrine Neoplasia

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  • Antibodies
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Sources for Multiple Endocrine Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet