MEA
MCID: MLT074
MIFTS: 58

Multiple Endocrine Neoplasia (MEA) malady

Cancer, Genetic categories

Summaries for Multiple Endocrine Neoplasia

Sources:
21Genetics Home Reference, 64Wikipedia, 33MalaCards
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Genetics Home Reference:21 Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.

MalaCards: Multiple Endocrine Neoplasia, also known as adenomatosis, familial endocrine, is related to thyroid medullary carcinoma and pheochromocytoma. An important gene associated with Multiple Endocrine Neoplasia is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Calcium Regulation in the Cardiac Cell and Glioblastoma Multiforme. The compounds calcium and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and thymus, and related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:64 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

Aliases & Classifications for Multiple Endocrine Neoplasia

Sources:
21Genetics Home Reference, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic


Aliases & Descriptions:

multiple endocrine neoplasia 21 45 61
adenomatosis, familial endocrine 21
familial endocrine adenomatosis 21
multiple endocrine adenomatosis 21
endocrine neoplasia, multiple 21
multiple endocrine neoplasms 21
men 21
mea 21


Related Diseases for Multiple Endocrine Neoplasia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Multiple Endocrine Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 793)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid medullary carcinoma31.6VHL, CALCA, GAST, MEN1, PRKAR1A, CHGA
2pheochromocytoma31.4VHL, RET, SDHD, SDHB
3zollinger-ellison syndrome31.4CHGA, MEN1, GAST
4primary hyperparathyroidism31.3CALCA, GAST, MEN1, PRKAR1A, CHGA, CDC73
5familial medullary thyroid carcinoma31.3CALCA, GDNF, RET
6gastrinoma31.3CHGA, MEN1, GAST
7adenoma31.2VHL, CALCA, GNAS, GAST, MEN1, PRKAR1A
8insulinoma31.2CHGA, MEN1, GAST, CALCA
9carcinoid syndrome31.1CALCA, GNAS, GAST, MEN1, CHGA, RET
10wermer syndrome31.1PRKAR1A, CHGA, NF1, CNC, CDC73, CDKN1B
11multiple endocrine neoplasia type 2a31.0NF1, CDC73, GDNF, RET, SDHD, SDHB
12phaeochromocytoma31.0CALCA, CHGA, RET, SDHD, SDHB, SDHC
13thyroid cancer30.9CALCA, GNAS, CDKN1B, RET
14prolactinoma30.9GNAS, MEN1, PRKAR1A, CHGA
15cushing's syndrome30.8CALCA, GNAS, MEN1, PRKAR1A, CHGA, CNC
16papillary carcinoma30.8CALCA, GNAS, CHGA, CDKN1B, RET
17acromegaly30.8GNAS, MEN1, PRKAR1A, CNC
18glucagonoma30.8CHGA, MEN1, GAST
19parathyroid carcinoma30.8MEN1, CDC73
20paraganglioma30.8VHL, CALCA, GAST, MEN1, CHGA, NF1
21pituitary tumors30.8CDKN1B, CNC, CHGA, PRKAR1A, GNAS, MEN1
22hirschsprung's disease30.8GDNF, RET
23ganglioneuroma30.8RET, CHGA
24adrenal adenoma30.7CNC, PRKAR1A, MEN1, GNAS
25familial isolated hyperparathyroidism30.7CDC73, MEN1
26neuroendocrine carcinoma30.7CALCA, GAST, MEN1, CHGA
27neurofibromatosis30.7NF1, SDHD, SDHB
28hypercalcemia30.6CALCA, GAST, MEN1, PRKAR1A, CHGA, CDC73
29carney complex30.6GNAS, MEN1, PRKAR1A, CDKN1B
30thyroid adenoma30.6GNAS, PRKAR1A, CNC, RET
31colorectal cancer30.5CDKN1B, NF1, MEN1, GAST
32vipoma30.4GAST, MEN1, CHGA
33pancreatic islet cell tumors30.2CALCA, GAST, MEN1, CHGA, RET
34somatostatinoma30.2CALCA, GAST, CHGA
35adenocarcinoma30.2VHL, GAST, MEN1, CHGA, CDKN1B
36uremia30.2MEN1
37gastrointestinal stromal tumor30.2SDHC, SDHB, NF1
38peutz-jeghers syndrome30.2CNC, PRKAR1A, VHL
39duodenal ulcer30.2GAST
40stomach cancer30.1CDKN1B, CHGA, GAST, VHL
41atrophic gastritis30.0GAST, MEN1, CHGA
42deficiency anemia30.0GNAS
43alzheimer's disease30.0GDNF
44parkinson's disease29.9GDNF
45von hippel-lindau disease29.5VHL, MEN1, NF1, RET, SDHD, SDHB
46acute leukemia29.5NF1
47short stature29.5NF1, GNAS
48graves' disease29.5GNAS
49n syndrome11.3
50pancreatic endocrine tumors10.8

Graphical network of the top 20 diseases related to Multiple Endocrine Neoplasia:



Diseases related to multiple endocrine neoplasia

Clinical Features for Multiple Endocrine Neoplasia

Drugs & Therapeutics for Multiple Endocrine Neoplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple Endocrine Neoplasia

Drug clinical trials:

Search ClinicalTrials for Multiple Endocrine Neoplasia

Search NIH Clinical Center for Multiple Endocrine Neoplasia

Search CenterWatch for Multiple Endocrine Neoplasia

Genetic Tests for Multiple Endocrine Neoplasia

Anatomical Context for Multiple Endocrine Neoplasia

Sources:
33MalaCards
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MalaCards organs/tissues related to Multiple Endocrine Neoplasia:

33
Whole blood, Lymph node, Thymus, Brain, Spinal cord, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, B cells, Endothelial, Tongue, Pancreatic islet, Pituitary

Animal Models for Multiple Endocrine Neoplasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Multiple Endocrine Neoplasia:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.2PRKAR1A, MEN1, GAST, GNAS, CALCA, VHL
2MP:000538511.1VHL, CALCA, GNAS, MEN1, PRKAR1A, CHGA
3MP:000537611.1MEN1, GAST, GNAS, CALCA, VHL, PRKAR1A
4MP:000200611.0VHL, CALCA, GAST, MEN1, PRKAR1A, NF1
5MP:000536711.0VHL, CALCA, GNAS, CHGA, NF1, CDC73
6MP:000538711.0VHL, GNAS, GAST, MEN1, PRKAR1A, NF1
7MP:000536911.0VHL, GNAS, MEN1, PRKAR1A, NF1, CDC73
8MP:000537911.0RET, GAST, MEN1, NF1, CDC73, CDKN1B
9MP:000537811.0VHL, GNAS, MEN1, PRKAR1A, CHGA, NF1
10MP:000538010.9VHL, CALCA, MEN1, PRKAR1A, NF1, CDC73
11MP:000538110.9VHL, GAST, MEN1, PRKAR1A, CDC73, CDKN1B
12MP:000539710.9VHL, GNAS, PRKAR1A, NF1, CDC73, CDKN1B
13MP:000538410.9VHL, GNAS, MEN1, PRKAR1A, NF1, CDC73
14MP:000538910.8VHL, MEN1, PRKAR1A, CDC73, CDKN1B, GDNF
15MP:000538810.8GNAS, PRKAR1A, NF1, CDKN1B
16MP:000538610.8CALCA, GNAS, NF1, CDC73, CDKN1B, GDNF
17MP:000363110.7GNAS, MEN1, NF1, CDC73, CDKN1B, GDNF
18MP:001077110.6CALCA, GNAS, CDC73, CDKN1B, PLCB3
19MP:000538210.5VHL, GNAS, MEN1, PRKAR1A, NF1, CDKN1B
20MP:000537010.3VHL, GNAS, MEN1, NF1, CDC73, CDKN1B

Publications for Multiple Endocrine Neoplasia

Sources:
51PubMed
See all sources

Articles related to Multiple Endocrine Neoplasia:

(show top 50)    (show all 1010)
idTitleAuthorsYear
1
Thymic carcinoid associated with multiple endocrine neoplasia syndrome type I. (22832394)
2013
2
Coexistence of Multiple Endocrine Neoplasia Type 2B and Chilaiditi Sign: A Case Report. (23119190)
2012
3
Cushing's syndrome in multiple endocrine neoplasia type 1. (21916912)
2012
4
Magnetic resonance imaging versus endoscopic ultrasonography for the detection of pancreatic tumours in multiple endocrine neoplasia type 1. (22078814)
2012
5
Confocal scan imaging and impression cytology of the cornea in a case of multiple endocrine neoplasia type-2b. (23275828)
2012
6
Education and imaging. Hepatobiliary and pancreatic: pancreatic VIPomas associated with multiple endocrine neoplasia type I. (22353352)
2012
7
Abraham Lincoln's marfanoid mother: the earliest known case of multiple endocrine neoplasia type 2B? (22504423)
2012
8
Total parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center. (22584718)
2012
9
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. (21455335)
2011
10
p27kip1: a new multiple endocrine neoplasia gene? (20980721)
2011
11
Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up. (20686291)
2010
12
The MENX syndrome and p27: relationships with multiple endocrine neoplasia. (20541671)
2010
13
Diffuse corneoscleral limbal neuromas with prominent corneal nerves in multiple endocrine neoplasia syndrome type IIB. (19645382)
2010
14
Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors. (19622622)
2009
15
Failure to recognize multiple endocrine neoplasia 2B: more common than we think? (17963006)
2008
16
Ocular findings in a child with multiple endocrine neoplasia type 2b. (18825906)
2008
17
Atypical thymic carcinoid in multiple endocrine neoplasia type 1 syndrome. (17848844)
2007
18
MEN1 mutation analysis in Chinese patients with multiple endocrine neoplasia type 1. (18045958)
2007
19
A newly detected mutation of the RET protooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A. (17704047)
2007
20
Multiple endocrine neoplasia type 2. (17105651)
2006
21
Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2. (16532227)
2006
22
Laparoscopic surgery in patients with sporadic and multiple insulinomas associated with multiple endocrine neoplasia type 1. (15749601)
2005
23
Molecular genetics of multiple endocrine neoplasia types 1 and 2. (15864278)
2005
24
A novel germline mutation, 1793delG, of the MEN1 gene underlying multiple endocrine neoplasia type 1. (15894711)
2005
25
Surgical treatment of hyperparathyroidism in patients with multiple endocrine neoplasia type 1. (15841561)
2005
26
Multiple endocrine neoplasia type 2 syndrome presenting with bowel obstruction caused by intestinal neuroma: case report. (15586612)
2004
27
Germline RET V804M mutation associated with multiple endocrine neoplasia type 2A. (15386323)
2004
28
Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism. (12699448)
2003
29
Plasma chromogranin A in patients with sporadic gastro-entero-pancreatic neuroendocrine tumors or multiple endocrine neoplasia type 1. (12534356)
2003
30
The RET C620S mutation causes multiple endocrine neoplasia type 2A (MEN2A) but not Hirschsprung disease (HSCR) in a family cosegregating both phenotypes. (14517954)
2003
31
Pituitary adenomas in adolescent patients with multiple endocrine neoplasia type 1. (12625413)
2002
32
Prophylactic total thyroidectomy in an 8-year-old girl with multiple endocrine neoplasia type 2A. (11393128)
2001
33
Familial isolated primary hyperparathyroidism--a multiple endocrine neoplasia type 1 variant? (11454510)
2001
34
Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. (11302744)
2001
35
The "serendipitous" surgical cure of the Zollinger-Ellison syndrome in a patient with multiple endocrine neoplasia type 1 despite an unsuspected diagnosis of either disease. (11246362)
2001
36
Multiple endocrine neoplasia: a clinical model for applying molecular genetic techniques]. (11050843)
2000
37
Internally shortened menin protein as a consequence of alternative RNA splicing due to a germline deletion in the multiple endocrine neoplasia type 1 gene. (10812010)
2000
38
A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1. (10228803)
1999
39
Utility of RET mutation analysis in multiple endocrine neoplasia type 2. (10539905)
1999
40
Association of multiple endocrine neoplasia type 2 and Hirschsprung disease. (9681852)
1998
41
Germ line mutation analysis in families with multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma. (9820617)
1998
42
RET protooncogene mutational analysis in multiple endocrine neoplasia syndrome type 2B: case report and review of the literature. (8884827)
1996
43
Surgical management of hyperparathyroidism in patients with multiple endocrine neoplasia type 2A. (8957482)
1996
44
Multiple endocrine neoplasia type 2B (mucosal neuroma syndrome, Wagenmann-Froboese syndrome). (8880581)
1996
45
A cluster of CpG islands at D10S94, near the locus responsible for multiple endocrine neoplasia type 2A (MEN2A). (1351867)
1992
46
Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus. (1362397)
1992
47
A case of multiple endocrine neoplasia: hyperparathyroidism, insulinoma, GRF-oma, hypercalcitoninaemia and intractable peptic ulceration. (1356665)
1992
48
The mapping of the locus for multiple endocrine neoplasia type 2A by linkage with chromosome 10 markers. (2572529)
1989
49
Results of a screening program for multiple endocrine neoplasia type 2A: a clinical study of a Japanese family. (2576943)
1989
50
Fasting hypoglycemia, hypercalcemia and hyperprolactinemia. Multiple endocrine neoplasia, type 1? (4372884)
1974

Genetic Variations for Multiple Endocrine Neoplasia

Expression for genes affiliated with Multiple Endocrine Neoplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multiple Endocrine Neoplasia

Search GEO for disease gene expression data for Multiple Endocrine Neoplasia.

Pathways for genes affiliated with Multiple Endocrine Neoplasia

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Multiple Endocrine Neoplasia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.2VHL, CALCA, GNAS, GAST, MEN1, PRKAR1A
2tyrosine4511.2VHL, GNAS, GAST, MEN1, CHGA, NF1
3vegf4511.2VHL, CALCA, GAST, MEN1, CHGA, CDKN1B
4cyclic amp45 2412.1CALCA, GNAS, PRKAR1A, CHGA, NF1, CNC
5serine4511.1VHL, GNAS, GAST, MEN1, CHGA, NF1
6oxygen45 2412.1VHL, GNAS, CHGA, CDKN1B, GDNF, SDHD
7succinate4511.1SDHC, VHL, NF1, RET, SDHD, SDHB
8adenylate4511.1CALCA, GNAS, GAST, PRKAR1A, CHGA, NF1
9dopamine45 29 11 2414.1GNAS, GAST, CHGA, NF1, GDNF, SDHB
10oligonucleotide4511.0VHL, GNAS, CHGA, NF1, CDKN1B, GDNF
11norepinephrine45 11 2413.0CALCA, GNAS, GAST, CHGA, GDNF, SDHB
12arginine4511.0GNAS, PRKAR1A, CHGA, NF1, CDKN1B, RET
13alanine4511.0GNAS, GAST, NF1, CDKN1B, GDNF, RET
14catecholamine4511.0CHGA, GDNF, RET, SDHD, SDHB
15mibg4511.0CALCA, CHGA, SDHD, SDHB
16fumarate45 1112.0VHL, SDHD, SDHB, SDHC
17glutamate4511.0GDNF, PRKAR1A, GAST, GNAS
18forskolin45 50 1113.0CALCA, PRKAR1A, GDNF
19UBIQUINONE-11111.0SDHC, SDHB, SDHD
20cysteine4511.0GNAS, PRKAR1A, CHGA, NF1, GDNF, RET
21octreotide45 60 29 1114.0CALCA, GNAS, GAST, CHGA
22vitamin d4511.0CALCA, GAST, MEN1, PRKAR1A, CHGA
23histidine4511.0VHL, GNAS, GAST, CHGA, SDHB
24glucose4511.0GAST, CDKN1B, GDNF, SDHB
25testosterone45 60 11 2414.0CALCA, GAST, CHGA, CDKN1B, RET, SDHB
262-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.9SDHC, SDHB, SDHD
27estrogen4510.9NF1
28succinic acid29 11 2412.9SDHD, SDHB, SDHC
29l-amino acid4510.9PRKAR1A, CHGA, GDNF
30iron-sulfur4510.9SDHD, SDHB, SDHC
31bromodeoxyuridine4510.9GAST, CHGA, CDKN1B, GDNF
32ubiquinone4510.9SDHD, SDHB, SDHC
33iron45 2411.9VHL, GDNF, SDHD, SDHB, SDHC
34nitric oxide45 11 2412.9GDNF, CDKN1B, CHGA, GNAS, CALCA, VHL
35isoproterenol45 1111.9CALCA, GNAS, GAST, CHGA
36fluoride4510.9NF1, CHGA, CALCA
37acth4510.8CHGA, GAST, GNAS, CALCA
38calcium gluconate4510.8GAST, CALCA
39creatinine4510.8CALCA, GAST, CHGA, GDNF, SDHB
40lafutidine4510.8CALCA, GAST
41111in-pentetreotide4510.8CHGA, CALCA
42epinephrine45 11 2412.7SDHB, CHGA, GAST, CALCA
43azoxymethane4510.7GAST, CDKN1B
44propranolol45 29 50 11 2414.7CALCA, GAST, CHGA
45pepsinogen4510.6CHGA, GAST
46retinoic acid45 2411.6CHGA, NF1, CDKN1B, GDNF, RET, SDHC
47cinacalcet45 29 1112.6PRKAR1A, CALCA
48atp45 2911.5CHGA, NF1, CDKN1B, GDNF, RET, SDHB
49i-app4510.5GAST, CALCA
50methionine4510.3RET, CDKN1B, NF1, CHGA

GO Terms for genes affiliated with Multiple Endocrine Neoplasia

Sources:
16Gene Ontology
See all sources

Cellular components related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00574910.5SDHC, SDHB, SDHD

Biological processes related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00609910.5SDHC, SDHB, SDHD
2respiratory electron transport chainGO:02290410.5SDHC, SDHB, SDHD
3positive regulation of adenylate cyclase activityGO:04576210.4NF1, CALCA
4MAPK cascadeGO:00016510.3MEN1, NF1, RET

Molecular functions related to Multiple Endocrine Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8CALCA, GNAS, GAST, MEN1, PRKAR1A, NF1
2ubiquinone bindingGO:04803910.2SDHB, SDHD

Products for genes affiliated with Multiple Endocrine Neoplasia

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  • Proteins
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Sources for Multiple Endocrine Neoplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet