MCID: MLT136
MIFTS: 63

Multiple Endocrine Neoplasia 1 malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases, Neuronal diseases, Fetal diseases categories

Aliases & Classifications for Multiple Endocrine Neoplasia 1

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Sources:
45OMIM, 10diseasecard, 9Disease Ontology, 19GeneReviews, 41NIH Rare Diseases, 20GeneTests, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 11DISEASES, 55SNOMED-CT, 33MeSH, 38NCIt, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Multiple Endocrine Neoplasia 1, Aliases & Descriptions:

Name: Multiple Endocrine Neoplasia 1 45 10
Multiple Endocrine Neoplasia Type 1 9 19 41 20 43 47 22 60
Wermer Syndrome 9 19 41 11 47
Men 1 41 47
Multiple Endocrine Neoplasia, Type I 45
Endocrine Adenomatosis Multiple 41
 
Multiple Endocrine Adenomatosis 19
Multiple Endocrine Neoplasia 60
Wermer's Syndrome 9
Men1 Syndrome 19
Men Type I 9
Men1 19


Classifications:



Characteristics (Orphanet epidemiological data):

47
multiple endocrine neoplasia type 1:
Inheritance: Autosomal dominant,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: adult


External Ids:

OMIM45 131100
Disease Ontology9 DOID:10017
MeSH33 D018761
NCIt38 C3225
ICD9CM27 258.01
SNOMED-CT55 190566000, 30664006
Orphanet47 652
MESH via Orphanet34 D018761
ICD10 via Orphanet26 D44.8
UMLS via Orphanet61 C0025267

Summaries for Multiple Endocrine Neoplasia 1

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OMIM:45 Multiple endocrine neoplasia type I (MEN1) is an autosomal dominant disorder characterized by varying combinations of... (131100) more...

MalaCards based summary: Multiple Endocrine Neoplasia 1, also known as multiple endocrine neoplasia type 1, is related to multiple endocrine neoplasia and pituitary adenoma, and has symptoms including hyperparathyroidism, abnormality of the hypothalamus-pituitary axis and exocrine pancreatic insufficiency. An important gene associated with Multiple Endocrine Neoplasia 1 is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Akt Signaling Pathway and C-MYB transcription factor network. The compounds mimosine and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, pancreas and thyroid, and related mouse phenotypes are craniofacial and liver/biliary system.

Disease Ontology:9 An autosomal dominant disease that has material basis in a mutation in the men1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.

NIH Rare Diseases:41 Multiple endocrine neoplasia, type 1 (men1) is an inherited condition that causes tumors of the endocrine system (the body's network of hormone-producing glands). people affected by men1 typically develop tumors of the parathyroid gland, the pituitary gland, and the pancreas, although other glands may be involved as well. these tumors are often "functional" and secrete excess hormones, which can cause a variety of health problems. the most common signs and symptoms of men1 are caused by hyperparathyroidism (overactive parathyroid gland) and may include kidney stones; thinning of bones; nausea and vomiting; high blood pressure (hypertension); weakness; and fatigue. men1 is caused by changes (mutations) in the men1 gene and is inherited in an autosomal dominant manner. management for men1 usually includes regular screening to allow for early diagnosis and treatment of endocrine tumors. last updated: 11/26/2014

Wikipedia:63 Multiple endocrine neoplasia type 1 (MEN-1 syndrome) or Wermer\'s syndrome is part of a group of... more...

GeneReviews summary for men1

Related Diseases for Multiple Endocrine Neoplasia 1

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Diseases in the Multiple Endocrine Neoplasia family:

Multiple Endocrine Neoplasia, Type Iv Multiple Endocrine Neoplasia Iia
Multiple Endocrine Neoplasia Iib multiple endocrine neoplasia 1

Diseases related to Multiple Endocrine Neoplasia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia31.4CDKN1B, MEN1
2pituitary adenoma31.0CDKN2B, CDKN1B, MEN1
3ependymoma30.9MEN1, CDKN2B
4pituitary tumors30.7MEN1, CDKN1B
5hyperparathyroidism30.6CDKN1B, MEN1
6thyroid cancer30.6CDKN1B, CDKN1A
7parathyroid adenoma30.3CDKN2C, CDKN1B, MEN1
8adenoma30.2MEN1, CDKN1A, CDKN1B, CDKN2C
9adenocarcinoma30.1CDKN1B, CDKN1A, MEN1
10pancreatic cancer30.1CDKN1A, MEN1
11breast cancer30.1MEN1, CDKN1A, CDKN1B, CDKN2C
12melanoma29.8CDKN1A, CDKN1B, CDKN2C, CDKN2B
13prostate cancer29.8CDKN2B, CDKN2C, CDKN1B, CDKN1A
14lung cancer29.6CDKN2B, CDKN1A
15hepatocellular carcinoma29.0MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
16leukemia29.0MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B
17zollinger-ellison syndrome10.7
18hyperparathyroidism, familial primary10.6
19gastrinoma10.6
20neuroendocrine carcinoma10.5
21thyroiditis10.5
22insulinoma10.5
23acromegaly10.5
24primary hyperparathyroidism10.5
25cushing's syndrome10.5
26neuroendocrine tumor10.5
27glucagonoma10.5
28hypoglycemia10.5
29hypercalcemia10.5
30pancreatic cholera10.5
31adrenocortical carcinoma10.5
32thymoma10.5
33thymic neuroendocrine carcinoma10.5
34parathyroid carcinoma10.3
35pituitary adenoma, prolactin-secreting10.3
36pituitary adenoma, growth hormone-secreting10.3
37islet cell tumor10.3
38adrenal cortical adenoma10.3
39vipoma10.3
40prolactinoma10.3
41duodenitis10.3
42adrenal adenoma10.3
43gigantism10.3
44pancreatic islet cell tumors10.3
45vibrio vulnificus infection10.3
46hyperprolactinemia10.3
47acth-independent macronodular adrenal hyperplasia10.3
48end stage renal failure10.3
49hemangioma10.3
50duodenal ulcer10.3

Graphical network of the top 20 diseases related to Multiple Endocrine Neoplasia 1:



Diseases related to multiple endocrine neoplasia 1

Symptoms for Multiple Endocrine Neoplasia 1

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Symptoms by clinical synopsis from OMIM:

131100

Clinical features from OMIM:

131100

Symptoms:

 47 (show all 13)
  • structural anomalies of the pancreas
  • anomalies of the endocrine glands
  • hypothalamic-hypophyseal axis anomalies/hypothalamus/pituitary anomalies
  • parathyroids anomalies
  • hyperparathyroidy
  • anomaly of pancreatic hormones
  • hypercalcemia
  • neoplasms/tumors
  • autosomal dominant inheritance
  • xanthomas/lipomas
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • thyroid anomalies
  • cortico-adrenal hyperplasia/hypersecretion

HPO human phenotypes related to Multiple Endocrine Neoplasia 1:

(show all 28)
id Description Frequency HPO Source Accession
1 hyperparathyroidism hallmark (90%) HP:0000843
2 abnormality of the hypothalamus-pituitary axis hallmark (90%) HP:0000864
3 exocrine pancreatic insufficiency hallmark (90%) HP:0001738
4 hypercalcemia hallmark (90%) HP:0003072
5 abnormality of the thyroid gland typical (50%) HP:0000820
6 multiple lipomas typical (50%) HP:0001012
7 hypercortisolism typical (50%) HP:0001578
8 abnormality of the gastric mucosa typical (50%) HP:0004295
9 autosomal dominant inheritance HP:0000006
10 abnormality of the thyroid gland HP:0000820
11 growth hormone excess HP:0000845
12 cafe-au-lait spot HP:0000957
13 subcutaneous lipoma HP:0001031
14 hypercortisolism HP:0001578
15 hypoglycemia HP:0001943
16 diarrhea HP:0002014
17 zollinger-ellison syndrome HP:0002044
18 pituitary adenoma HP:0002893
19 parathyroid adenoma HP:0002897
20 hypercalcemia HP:0003072
21 peptic ulcer HP:0004398
22 pituitary prolactin cell adenoma HP:0006767
23 confetti-like hypopigmented macules HP:0007449
24 adrenocortical adenoma HP:0008256
25 adenoma sebaceum HP:0009720
26 insulinoma HP:0012197
27 carcinoid HP:0100570
28 esophagitis HP:0100633

Drugs & Therapeutics for Multiple Endocrine Neoplasia 1

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Drug clinical trials:

Search ClinicalTrials for Multiple Endocrine Neoplasia 1

Search NIH Clinical Center for Multiple Endocrine Neoplasia 1

Genetic Tests for Multiple Endocrine Neoplasia 1

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Genetic tests related to Multiple Endocrine Neoplasia 1:

id Genetic test Affiliating Genes
1 Multiple Endocrine Neoplasia Type 120 MEN1
2 Multiple Endocrine Neoplasia, Type 122

Anatomical Context for Multiple Endocrine Neoplasia 1

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MalaCards organs/tissues related to Multiple Endocrine Neoplasia 1:

31
Pituitary, Pancreas, Thyroid, Bone, Kidney, Pancreatic islet, Spinal cord, Hypothalamus

Animal Models for Multiple Endocrine Neoplasia 1 or affiliated genes

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Publications for Multiple Endocrine Neoplasia 1

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Articles related to Multiple Endocrine Neoplasia 1:

idTitleAuthorsYear
1
Bilateral granulosa cell tumors: a novel malignant manifestation of multiple endocrine neoplasia 1 syndrome found in a patient with a rare menin in-frame deletion. (25733923)
2015
2
An unusual presentation of a patient with multiple endocrine neoplasia- 1. (25653982)
2014
3
Pancreatic adenocarcinoma in a patient with multiple endocrine neoplasia 1 syndrome. (23591436)
2013
4
Novel association of thymic carcinoid with a germline mutation in a kindred with multiple endocrine neoplasia 1 (MEN1). (22549346)
2012
5
Multiple endocrine neoplasia 1: providing care for the family. (20880824)
2010
6
Causes and treatment of recurrent hyperparathyroidism after subtotal parathyroidectomy in the presence of multiple endocrine neoplasia 1. (20431882)
2010
7
Gene symbol: MEN1. Disease: Multiple endocrine neoplasia 1. (20960638)
2008
8
Diffuse gastric carcinoid polyposis in multiple endocrine neoplasia 1 syndrome without hypergastrinemia. (17524399)
2007
9
Thymic carcinoid in multiple endocrine neoplasia 1: genotype-phenotype correlation and prevention. (16594911)
2006
10
Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas. (9498491)
1998

Variations for Multiple Endocrine Neoplasia 1

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UniProtKB/Swiss-Prot genetic disease variations for Multiple Endocrine Neoplasia 1:

62 (show all 90)
id Symbol AA change Variation ID SNP ID
1MEN1p.Pro12LeuVAR_005425
2MEN1p.Leu22ArgVAR_005426
3MEN1p.Glu26LysVAR_005427rs28931612
4MEN1p.Leu39TrpVAR_005428
5MEN1p.Gly42AspVAR_005429
6MEN1p.Glu45GlyVAR_005430
7MEN1p.His139AspVAR_005432
8MEN1p.His139TyrVAR_005433
9MEN1p.Lys135IleVAR_005434
10MEN1p.Phe144ValVAR_005436
11MEN1p.Ala165ProVAR_005437
12MEN1p.Ala169AspVAR_005438
13MEN1p.Asp177TyrVAR_005441
14MEN1p.Ala181ProVAR_005442
15MEN1p.Glu184AspVAR_005443
16MEN1p.Trp188SerVAR_005444
17MEN1p.Leu228ProVAR_005446
18MEN1p.Ala247ValVAR_005447
19MEN1p.Leu269ProVAR_005449
20MEN1p.Ala289GluVAR_005451
21MEN1p.Leu291ProVAR_005452
22MEN1p.Ala314ProVAR_005453
23MEN1p.Arg319ProVAR_005454
24MEN1p.Ala342AspVAR_005455rs2071312
25MEN1p.Trp346ArgVAR_005456
26MEN1p.Thr349ArgVAR_005457
27MEN1p.Glu364LysVAR_005458
28MEN1p.Ala373AspVAR_005460
29MEN1p.Asp423AsnVAR_005461
30MEN1p.Trp441ArgVAR_005464
31MEN1p.Phe452SerVAR_005465
32MEN1p.Ser560AsnVAR_005467
33MEN1p.Gly161AspVAR_008017
34MEN1p.Cys246ArgVAR_008018
35MEN1p.Glu45LysVAR_039587
36MEN1p.Arg98LeuVAR_039588
37MEN1p.Gly110GluVAR_039589
38MEN1p.His139ProVAR_039590
39MEN1p.His139ArgVAR_039591
40MEN1p.Asp158ValVAR_039592
41MEN1p.Ser159IleVAR_039593
42MEN1p.Ser160PheVAR_039594
43MEN1p.Ala165ThrVAR_039595
44MEN1p.Val167PheVAR_039596
45MEN1p.Cys170ArgVAR_039597
46MEN1p.Leu173ProVAR_039598
47MEN1p.Glu184LysVAR_039599
48MEN1p.Glu184GlnVAR_039600
49MEN1p.His186ArgVAR_039601
50MEN1p.Trp188ArgVAR_039602
51MEN1p.Val220MetVAR_039603
52MEN1p.Gly230ArgVAR_039604
53MEN1p.Arg234LeuVAR_039605
54MEN1p.Val245PheVAR_039606
55MEN1p.Cys246PheVAR_039607
56MEN1p.Cys246TyrVAR_039608
57MEN1p.Ser258ProVAR_039609
58MEN1p.Leu264ArgVAR_039611
59MEN1p.Gly286ArgVAR_039616
60MEN1p.Thr316ProVAR_039619
61MEN1p.His322ArgVAR_039620
62MEN1p.His322TyrVAR_039621
63MEN1p.Pro325LeuVAR_039622
64MEN1p.Pro325ArgVAR_039623
65MEN1p.Ala330ProVAR_039624
66MEN1p.Ala342ProVAR_039625
67MEN1p.Ala347ProVAR_039626
68MEN1p.Ile353AsnVAR_039627
69MEN1p.Tyr358AspVAR_039628
70MEN1p.Arg360TrpVAR_039629
71MEN1p.Asp362HisVAR_039630
72MEN1p.Ile377MetVAR_039631
73MEN1p.Pro378SerVAR_039632
74MEN1p.Ala390ValVAR_039633
75MEN1p.Ala416ProVAR_039634
76MEN1p.Leu419ProVAR_039635
77MEN1p.Arg420ProVAR_039636
78MEN1p.Asp423HisVAR_039637
79MEN1p.Cys426TyrVAR_039638
80MEN1p.Trp428SerVAR_039639
81MEN1p.Ser432ArgVAR_039640
82MEN1p.Trp441CysVAR_039641
83MEN1p.Leu449ProVAR_039642
84MEN1p.Arg532CysVAR_039643
85MEN1p.Pro545SerVAR_039644
86MEN1p.Pro549SerVAR_039645
87MEN1p.Ser560ArgVAR_039647
88MEN1p.Ile147PheVAR_065153
89MEN1p.Leu418ArgVAR_065155
90MEN1p.Trp476CysVAR_065156

Clinvar genetic disease variations for Multiple Endocrine Neoplasia 1:

6 (show all 42)
id Gene Variation Type Significance SNP ID Assembly Location
1MEN1NM_000244.3(MEN1): c.65T> G (p.Leu22Arg)single nucleotide variantPathogenicrs104894256GRCh37Chr 11, 64577517: 64577517
2MEN1MEN1, 4-BP DEL, NT357deletionPathogenic
3MEN1MEN1, 1-BP DEL, 416CdeletionPathogenic
4MEN1MEN1, 3-BP DEL, LYS119DELdeletionPathogenic
5MEN1NM_000244.3(MEN1): c.402delC (p.Phe134Leufs)deletionPathogenicrs397515385GRCh37Chr 11, 64577180: 64577180
6MEN1NM_000244.3(MEN1): c.608G> A (p.Trp203Ter)single nucleotide variantPathogenicrs104894258GRCh37Chr 11, 64575424: 64575424
7MEN1MEN1, 4-BP DEL, NT735deletionPathogenic
8MEN1MEN1, 1-BP DEL, 1132GdeletionPathogenic
9MEN1MEN1, 3-BP DEL, GLU363DELdeletionPathogenic
10MEN1NM_000244.3(MEN1): c.1321T> A (p.Trp441Arg)single nucleotide variantPathogenicrs104894259GRCh37Chr 11, 64572550: 64572550
11MEN1NM_000244.3(MEN1): c.1322G> A (p.Trp441Ter)single nucleotide variantPathogenicrs104894260GRCh37Chr 11, 64572549: 64572549
12MEN1NM_000244.3(MEN1): c.1594C> T (p.Arg532Ter)single nucleotide variantPathogenicrs104894261GRCh37Chr 11, 64572060: 64572060
13MEN1NM_000244.3(MEN1): c.793C> T (p.Gln265Ter)single nucleotide variantPathogenicrs104894266GRCh37Chr 11, 64575029: 64575029
14MEN1NM_000244.3(MEN1): c.1393C> T (p.Arg465Ter)single nucleotide variantPathogenicrs104894267GRCh37Chr 11, 64572261: 64572261
15MEN1NM_000244.3(MEN1): c.415C> G (p.His139Asp)single nucleotide variantPathogenicrs104894263GRCh37Chr 11, 64577167: 64577167
16MEN1MEN1, IVS4, G-A, -9single nucleotide variantPathogenic
17MEN1MEN1, 3-BP DEL, 2641GAAdeletionPathogenic
18MEN1MEN1, 4-BP DEL, 4480CAGTdeletionPathogenic
19MEN1NM_000244.3(MEN1): c.1267G> A (p.Asp423Asn)single nucleotide variantPathogenicrs104894264GRCh37Chr 11, 64572604: 64572604
20MEN1MEN1, 1-BP DEL, 7773CdeletionPathogenic
21MEN1NM_000244.3(MEN1): c.1077C> A (p.Cys359Ter)single nucleotide variantPathogenicrs104894265GRCh37Chr 11, 64573230: 64573230
22MEN1MEN1, 6-BP INS, NT879insertionPathogenic
23MEN1MEN1, 12-BP DEL, NT1466deletionPathogenic
24MEN1MEN1, 1-BP INS, 1657CinsertionPathogenic
25MEN1MEN1, IVS5, G-A, +1single nucleotide variantPathogenic
26MEN1NM_000244.3(MEN1): c.1028dupT (p.Gln344Alafs)duplicationLikely pathogenicrs386134245GRCh37Chr 11, 64573739: 64573740
27MEN1NM_000244.3(MEN1): c.1078delC (p.Arg360Glyfs)deletionLikely pathogenicrs386134246GRCh37Chr 11, 64573229: 64573229
28MEN1NM_000244.3(MEN1): c.1189dupG (p.Glu397Glyfs)duplicationLikely pathogenicrs386134247GRCh37Chr 11, 64573117: 64573118
29MEN1NM_000244.3(MEN1): c.119_124delTGCTGG (p.Val40_Leu41del)deletionLikely pathogenicrs386134248GRCh37Chr 11, 64577458: 64577463
30MEN1NM_000244.3(MEN1): c.1277G> A (p.Cys426Tyr)single nucleotide variantLikely pathogenicrs386134249GRCh37Chr 11, 64572594: 64572594
31MEN1NM_000244.3(MEN1): c.1A> G (p.Met1Val)single nucleotide variantLikely pathogenicrs386134250GRCh37Chr 11, 64577581: 64577581
32MEN1NM_000244.3(MEN1): c.211_212delCC (p.Pro71Alafs)deletionPathogenicrs386134251GRCh37Chr 11, 64577370: 64577371
33MEN1NM_000244.3(MEN1): c.252dupT (p.Ile85Tyrfs)duplicationLikely pathogenicrs386134253GRCh37Chr 11, 64577329: 64577330
34MEN1NM_000244.3(MEN1): c.417C> G (p.His139Gln)single nucleotide variantLikely pathogenicrs386134254GRCh37Chr 11, 64577165: 64577165
35MEN1NM_000244.3(MEN1): c.480_481insAATT (p.Gly161Asnfs)insertionLikely pathogenicrs386134255GRCh37Chr 11, 64575551: 64575552
36MEN1NM_000244.3(MEN1): c.518T> C (p.Leu173Pro)single nucleotide variantPathogenicrs386134256GRCh37Chr 11, 64575514: 64575514
37MEN1NM_000244.3(MEN1): c.659_667delTGGCTGAGCinsGCCCCT (p.Val220_Arg223delinsGlyProTrp)indelLikely pathogenicrs386134257GRCh37Chr 11, 64575365: 64575373
38MEN1NM_000244.3(MEN1): c.664_669+2delGAGCGGGTdeletionLikely pathogenicrs386134258GRCh37Chr 11, 64575361: 64575368
39MEN1NM_000244.3(MEN1): c.773C> A (p.Ser258Ter)single nucleotide variantLikely pathogenicrs386134259GRCh37Chr 11, 64575049: 64575049
40MEN1NM_000244.3(MEN1): c.951C> G (p.Tyr317Ter)single nucleotide variantLikely pathogenic, Pathogenicrs386134260GRCh37Chr 11, 64573817: 64573817
41MEN1NM_000244.3(MEN1): c.970dupT (p.Tyr324Leufs)duplicationLikely pathogenicrs386134261GRCh37Chr 11, 64573797: 64573798
42MEN1MEN1, IVS3DS, G-A, +1single nucleotide variantPathogenic

Expression for genes affiliated with Multiple Endocrine Neoplasia 1

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Search GEO for disease gene expression data for Multiple Endocrine Neoplasia 1.

Pathways for genes affiliated with Multiple Endocrine Neoplasia 1

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Pathways related to Multiple Endocrine Neoplasia 1 according to GeneCards Suite gene sharing:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CDKN1B, CDKN1A
29.4CDKN1B, CDKN1A
39.4CDKN1B, CDKN1A
49.4CDKN1A, CDKN1B
5
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.4CDKN1B, CDKN1A
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.4CDKN1A, CDKN1B
79.4CDKN1B, CDKN1A
89.4CDKN1A, CDKN1B
9
Show member pathways
DNA damage response36
9.4CDKN1B, CDKN1A
109.4CDKN1B, CDKN1A
11
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.4CDKN1B, CDKN1A
12
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.4CDKN1B, CDKN1A
13
Show member pathways
9.4CDKN1B, CDKN1A
14
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.4CDKN1A, CDKN1B
15
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.4CDKN1B, CDKN1A
16
Show member pathways
9.4CDKN1A, CDKN1B
179.4CDKN1B, CDKN1A
189.4CDKN1B, CDKN1A
19
Show member pathways
AhR pathway36
9.4CDKN1B, CDKN1A
209.4CDKN1B, CDKN1A
21
Show member pathways
9.4MEN1, CDKN2B
229.3CDKN1B, CDKN2B
239.3CDKN2B, CDKN1A
249.3CDKN2B, CDKN1A
259.0CDKN2B, CDKN2C
268.8CDKN1A, CDKN1B, CDKN2B
278.8CDKN2B, CDKN1B, CDKN1A
28
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
8.8CDKN1A, CDKN1B, CDKN2B
298.8CDKN2B, CDKN1B, CDKN1A
308.8CDKN1A, CDKN1B, CDKN2B
31
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.8CDKN2B, CDKN1B, CDKN1A
32
Show member pathways
8.8CDKN2B, CDKN1B, CDKN1A
33
Show member pathways
8.6CDKN2C, CDKN1B, CDKN1A
348.6CDKN2C, CDKN1B, CDKN1A
358.5CDKN2B, CDKN2C, CDKN1A
36
Show member pathways
8.4CDKN2B, CDKN1B, CDKN1A, MEN1
378.4MEN1, CDKN1A, CDKN1B, CDKN2B
388.2MEN1, CDKN1A, CDKN1B, CDKN2C
39
Show member pathways
8.0CDKN2B, CDKN2C, CDKN1B, CDKN1A
40
Show member pathways
8.0CDKN1A, CDKN1B, CDKN2C, CDKN2B
41
Show member pathways
Signaling Pathways in Glioblastoma36
8.0CDKN2B, CDKN2C, CDKN1B, CDKN1A
42
Show member pathways
8.0CDKN1A, CDKN1B, CDKN2C, CDKN2B
43
Show member pathways
8.0CDKN2B, CDKN2C, CDKN1B, CDKN1A
44
Show member pathways
8.0CDKN1A, CDKN1B, CDKN2C, CDKN2B
45
Show member pathways
8.0CDKN1A, CDKN1B, CDKN2C, CDKN2B
46
Show member pathways
Cell cycle36
7.5CDKN2B, CDKN2C, CDKN1B, CDKN1A, MEN1

Compounds for genes affiliated with Multiple Endocrine Neoplasia 1

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Compounds related to Multiple Endocrine Neoplasia 1 according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1mimosine43 1210.8CDKN1B, CDKN1A
2eb 108943 5910.8CDKN1B, CDKN1A
3aphidicolin439.8CDKN1B, CDKN1A
4ciglitazone43 2810.8CDKN1A, CDKN1B
5ns 39843 5910.8CDKN1B, CDKN1A
6indole-3-carbinol439.8CDKN1A, CDKN1B
7leptomycin b43 5910.8CDKN1A, CDKN1B
8flavopiridol43 1210.8CDKN1B, CDKN1A
9celecoxib43 59 28 49 24 1214.8CDKN1B, CDKN1A
10bortezomib43 49 1211.7CDKN1A, CDKN1B
11gefitinib43 49 1211.7CDKN1B, CDKN1A
12gemcitabine43 49 1211.7CDKN1B, CDKN1A
13lactacystin439.7CDKN1B, CDKN1A
14lovastatin43 49 59 28 1213.7CDKN1A, CDKN1B
15resveratrol43 59 24 1212.7CDKN1A, CDKN1B
16troglitazone43 28 59 1212.6CDKN1B, CDKN1A
17camptothecin43 59 1211.6CDKN1B, CDKN1A
18egcg439.6CDKN1A, CDKN1B
19p003439.6CDKN2B, CDKN1B
20bromodeoxyuridine439.5CDKN1B, CDKN1A
21mg 13243 5910.5CDKN1A, CDKN1B
22imatinib43 49 1211.3CDKN1B, CDKN1A
23arsenite43 2410.3CDKN2B, CDKN1A
24thymidine43 2410.3CDKN1B, CDKN1A, MEN1
25vegf439.3MEN1, CDKN1A, CDKN1B
26cytarabine43 49 1211.2CDKN1A, CDKN1B, CDKN2B
27tgf beta1439.2CDKN2B, CDKN1B, CDKN1A
28pd 98,059439.2CDKN1A, CDKN1B, CDKN2B
295-aza-2deoxycytidine439.0CDKN2B, CDKN1A
30retinoic acid43 249.8CDKN1A, CDKN1B, CDKN2B
31estrogen438.7CDKN2B, CDKN1B, CDKN1A, MEN1
32tyrosine438.7CDKN2B, CDKN1B, CDKN1A, MEN1
33threonine438.4CDKN1A, CDKN1B, CDKN2C, CDKN2B
34serine437.9CDKN2B, CDKN2C, CDKN1B, CDKN1A, MEN1

GO Terms for genes affiliated with Multiple Endocrine Neoplasia 1

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Cellular components related to Multiple Endocrine Neoplasia 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056549.0CDKN1B, CDKN1A, MEN1
2cytosolGO:00058297.4CDKN2B, CDKN2C, CDKN1B, CDKN1A, MEN1
3nucleusGO:00056347.2MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B

Biological processes related to Multiple Endocrine Neoplasia 1 according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:00718509.7CDKN1B, CDKN1A
2response to UVGO:00094119.6MEN1, CDKN1A
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:00305119.6CDKN2B, MEN1
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.5CDKN1B, CDKN1A
5cellular response to extracellular stimulusGO:00316689.5CDKN2B, CDKN1A
6transforming growth factor beta receptor signaling pathwayGO:00071799.5CDKN2B, MEN1
7phosphatidylinositol-mediated signalingGO:00480159.4CDKN1A, CDKN1B
8fibroblast growth factor receptor signaling pathwayGO:00085439.4CDKN1B, CDKN1A
9negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.3CDKN1B, CDKN1A, MEN1
10negative regulation of protein serine/threonine kinase activityGO:00719019.3CDKN2C, CDKN2B
11G2/M transition of mitotic cell cycleGO:00000869.2CDKN2B, CDKN1A
12cellular response to DNA damage stimulusGO:00069749.2CDKN1A, MEN1
13negative regulation of cell growthGO:00303088.9CDKN1A, CDKN1B, CDKN2C
14G1/S transition of mitotic cell cycleGO:00000828.9CDKN2C, CDKN1B, CDKN1A
15negative regulation of phosphorylationGO:00423268.3CDKN1A, CDKN1B, CDKN2C, CDKN2B
16regulation of cyclin-dependent protein serine/threonine kinase activityGO:00000798.3CDKN2B, CDKN2C, CDKN1B, CDKN1A
17mitotic cell cycleGO:00002788.3CDKN1A, CDKN1B, CDKN2C, CDKN2B
18cell cycle arrestGO:00070507.9CDKN2B, CDKN2C, CDKN1B, CDKN1A, MEN1
19negative regulation of cell proliferationGO:00082857.8MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B

Molecular functions related to Multiple Endocrine Neoplasia 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.4CDKN1B, CDKN1A
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048617.9CDKN2B, CDKN2C, CDKN1B, CDKN1A
3protein bindingGO:00055157.2MEN1, CDKN1A, CDKN1B, CDKN2C, CDKN2B

Products for genes affiliated with Multiple Endocrine Neoplasia 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Multiple Endocrine Neoplasia 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet