MEN4
MCID: MLT067
MIFTS: 22

Multiple Endocrine Neoplasia Type 4 (MEN4) malady

Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases categories

Summaries for Multiple Endocrine Neoplasia Type 4

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MalaCards based summary: Multiple Endocrine Neoplasia Type 4, also known as multiple endocrine neoplasia, type iv, is related to multiple endocrine neoplasia and wermer syndrome, and has symptoms including autosomal dominant inheritance, growth hormone excess and pituitary adenoma. An important gene associated with Multiple Endocrine Neoplasia Type 4 is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)).

Description from OMIM:46 610755

Aliases & Classifications for Multiple Endocrine Neoplasia Type 4

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Sources:
21GeneTests, 23GTR, 46OMIM, 48Orphanet, 61UMLS, 27ICD10 via Orphanet
See all sources

Multiple Endocrine Neoplasia Type 4, Aliases & Descriptions:

Name: Multiple Endocrine Neoplasia Type 4 21 23 48
Multiple Endocrine Neoplasia, Type Iv 46 61
 
Men4 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
multiple endocrine neoplasia type 4:
Inheritance: Autosomal dominant


External Ids:

OMIM46 610755
ICD10 via Orphanet27 D44.8

Related Diseases for Multiple Endocrine Neoplasia Type 4

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Diseases in the Multiple Endocrine Neoplasia Type 2a family:

multiple endocrine neoplasia type 4 Multiple Endocrine Neoplasia

Diseases related to Multiple Endocrine Neoplasia Type 4 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia10.3
2wermer syndrome10.1

Symptoms for Multiple Endocrine Neoplasia Type 4

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Symptoms by clinical synopsis from OMIM:

610755

Clinical features from OMIM:

610755

HPO human phenotypes related to Multiple Endocrine Neoplasia Type 4:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 growth hormone excess HP:0000845
3 pituitary adenoma HP:0002893
4 renal angiomyolipoma HP:0006772

Drugs & Therapeutics for Multiple Endocrine Neoplasia Type 4

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Drug clinical trials:

Search ClinicalTrials for Multiple Endocrine Neoplasia Type 4

Search NIH Clinical Center for Multiple Endocrine Neoplasia Type 4

Genetic Tests for Multiple Endocrine Neoplasia Type 4

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Genetic tests related to Multiple Endocrine Neoplasia Type 4:

id Genetic test Affiliating Genes
1 Multiple Endocrine Neoplasia Type 421 CDKN1B
2 Multiple Endocrine Neoplasia, Type 423

Anatomical Context for Multiple Endocrine Neoplasia Type 4

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Animal Models for Multiple Endocrine Neoplasia Type 4 or affiliated genes

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Publications for Multiple Endocrine Neoplasia Type 4

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Articles related to Multiple Endocrine Neoplasia Type 4:

idTitleAuthorsYear
1
Multiple endocrine neoplasia type 4. (23652671)
2013

Variations for Multiple Endocrine Neoplasia Type 4

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Clinvar genetic disease variations for Multiple Endocrine Neoplasia Type 4:

7
id Gene Name Type Significance SNP ID Assembly Location
1CDKN1BNM_004064.4(CDKN1B): c.227G> A (p.Trp76Ter)single nucleotide variantPathogenicrs121917832GRCh37Chr 12, 12871000: 12871000

Expression for genes affiliated with Multiple Endocrine Neoplasia Type 4

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Expression patterns in normal tissues for genes affiliated with Multiple Endocrine Neoplasia Type 4

Search GEO for disease gene expression data for Multiple Endocrine Neoplasia Type 4.

Pathways for genes affiliated with Multiple Endocrine Neoplasia Type 4

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Compounds for genes affiliated with Multiple Endocrine Neoplasia Type 4

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GO Terms for genes affiliated with Multiple Endocrine Neoplasia Type 4

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Products for genes affiliated with Multiple Endocrine Neoplasia Type 4

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Multiple Endocrine Neoplasia Type 4

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet