MCID: MLT019
MIFTS: 89

Multiple Myeloma malady

Cancer diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases categories

Summaries for Multiple Myeloma

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss repeated infections frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma. An important gene associated with Multiple Myeloma is IRF4 (interferon regulatory factor 4), and among its related pathways is Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs carmustine and cisplatin and the compounds thalidomide and baff have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:42 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys. multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

Wikipedia:63 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

Description from OMIM:46 254500

Aliases & Classifications for Multiple Myeloma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 22GTR, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
multiple myeloma:
Prevalence: 1-5/10000; Age of onset: Adulthood
primary amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

multiple myeloma 8 9 42 46 10 48 33 30 60
plasma cell myeloma 42 44 48
primary systemic amyloidosis 48 60
medullary plasmacytoma 48 60
plasma cell dyscrasia 42 60
primary amyloidosis 48 60
myeloma - multiple 42 22
myelomatosis 42 48
systemic immunoglobulinic amyloidosis 48
immunoglobulin deposition disease 60
immunoglobulinic amyloidosis 48
systemic al amyloidosis 48
light-chain amyloidosis 48
kahler's disease 48
al amyloidosis 48
kahler disease 42


External Ids:

Disease Ontology8 DOID:9538
NCIt39 C3242
OMIM46 254500
MeSH34 D009101
ICD9CM27 203.0
ICD10 via Orphanet26 E85.0, E85.1, E85.2 E85.3, C90.0, E85.8, more
SNOMED-CT via Orphanet57 23132008, 109989006, 55921005
MESH via Orphanet35 D009101, C531616
UMLS via Orphanet61 C0026764, C0268381
ICD1025 C90.0

Related Diseases for Multiple Myeloma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Multiple Myeloma family:

Myeloma Familial Myeloma

Diseases related to Multiple Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma32.5CCND1, TNFRSF17, IRF4, DKK1, MYEOV, IL6R
2plasmacytoma31.3IL6R, IRF4
3amyloidosis31.1APOA1
4chronic lymphocytic leukemia30.7CCND1, TNFRSF13C, TNFRSF17
5hypercalcemia30.6IL6R
6arthritis30.5IL6R
7non-hodgkin lymphoma30.5CCND1, TNFRSF13C, TNFRSF17, IRF4, IL6R
8rheumatoid arthritis30.2TNFRSF13C, TNFRSF17, APOA1, DKK1, IL6R
9multiple sclerosis30.2TNFRSF13C, TNFRSF17, APOA1, IL6R
10plasma cell leukemia30.2CCND1
11lung cancer30.1CCND1
12leukemia10.9
13hodgkin's lymphoma10.7
14extramedullary plasmacytoma10.6
15acute leukemia10.6
16smoldering myeloma10.6
17macroglobulinemia10.6
18neuropathy10.6
19glomerulonephritis10.5
20purpura10.5
21cryoglobulinemia10.4
22cutis laxa10.4
23peripheral neuropathy10.4
24hepatitis10.4
25osteonecrosis10.4
26fanconi syndrome10.4
27myeloid leukemia10.3
28prostatitis10.3
29gaucher's disease10.3
30herpes zoster10.3
31adult syndrome10.3
32poems syndrome10.3
33keratopathy10.3
34kidney disease10.3
35osteosclerosis10.3
36pure red-cell aplasia10.3
37von willebrand's disease10.3
38angiodysplasia10.3
39acute myeloid leukemia10.3
40stevens-johnson syndrome10.3
41thrombotic thrombocytopenic purpura10.3
42bone lymphoma10.3
43monoclonal gammopathy of uncertain significance10.3
44arthropathy10.3
45breast cancer10.3
46prostate cancer10.3
47retinoblastoma10.3
48primary polycythemia10.2
49t-cell large granular lymphocyte leukemia10.2
50graft versus host disease10.2

Graphical network of the top 20 diseases related to Multiple Myeloma:



Diseases related to multiple myeloma

Clinical Features for Multiple Myeloma

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46OMIM
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Clinical features from OMIM:

254500

Clinical synopsis from OMIM:

254500

Drugs & Therapeutics for Multiple Myeloma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Multiple Myeloma

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22GTR
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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma22

Anatomical Context for Multiple Myeloma

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Multiple Myeloma:

32
Bone, Bone marrow, Kidney, Testes, Endothelial, B cells, T cells, Testis, Lung, Myeloid, Breast, Nk cells, Skin, Liver, Prostate, Pituitary, Monocytes, Whole blood, Heart, Spinal cord, Thyroid, Tongue, Brain, Lymph node, Colon, Pancreas, Skeletal muscle

FMA organs/tissues related to Multiple Myeloma:

14
The plasma cells in bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Multiple Myeloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.0NBEA, PDZK1, TNFRSF13C, APOA1, LIG4, DKK1

Publications for Multiple Myeloma

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Sources:
50PubMed
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Articles related to Multiple Myeloma:

(show top 50)    (show all 2849)
idTitleAuthorsYear
1
Breaking the Invulnerability of Cancer Stem Cells: Two-Step Strategy to Kill the Stem-like Cell Subpopulation of Multiple Myeloma. (24174494)
2014
2
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
3
Safety and efficacy of autologous hemopoietic progenitor cell collection in tandem with hemodialysis in multiple myeloma with myeloma cast nephropathy. (23959911)
2013
4
The effect of gradual increment in rhG-CSF dose on stem cell yields in patients with multiple myeloma mobilized with intermediate dose cyclophosphamide plus rhG-CSF. (24342458)
2013
5
Cardiac amyloidosis masquerading as biventricular hypertrophy in a patient with multiple myeloma. (23897372)
2013
6
Targeting BRAF in multiple myeloma. (23928771)
2013
7
Multiple myeloma with cavernous sinus involvement. (24018157)
2013
8
Multiple myeloma: from diagnosis to treatment. (24130968)
2013
9
Clinical significance of the appearance of abnormal protein band in patients with multiple myeloma. (23999647)
2013
10
Novel generation of agents with proven clinical activity in multiple myeloma. (24135407)
2013
11
Concurrent presentation of hodgkin lymphoma and multiple myeloma. (24027647)
2013
12
Clinical updates in blood and marrow transplantation in multiple myeloma. (24280457)
2013
13
Growth Differentiation Factor 15 in Multiple Myeloma: A Microenvironment Factor Predictive of Response to Treatment? (24216505)
2013
14
Individual quality of life in patients with multiple myeloma. (24024087)
2013
15
Bone marrow-derived mesenchymal stromal cells are attracted by multiple myeloma cell-produced chemokine CCL25 and favor myeloma cell growth in vitro and in vivo. (22102554)
2012
16
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. (22558078)
2012
17
Bortezomib-induced peripheral neuropathy in patients with multiple myeloma. (22297012)
2012
18
Multiple myeloma: treatment- related peripheral neuropathy. (23249799)
2012
19
Multiple myeloma with hypercalcemia and chloride resistant metabolic alkalosis. (22073517)
2011
20
HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients. (21183939)
2011
21
Multiple myeloma associated IgA pemphigus: treatment with bortezomib- and lenalidomide-based regimen. (21856265)
2011
22
Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization. (19483760)
2010
23
INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. (20072651)
2010
24
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma. (20008301)
2010
25
An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma. (19714603)
2009
26
Polymorphisms and haplotypes in the multidrug resistance 1 gene (MDR1/ABCB1) and risk of multiple myeloma. (18639335)
2009
27
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
28
AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. (18242516)
2008
29
Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. (18305214)
2008
30
Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. (17363736)
2007
31
Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease. (17171682)
2007
32
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. (17354015)
2007
33
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
34
Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells]. (17064599)
2006
35
Cytogenetics and molecular cytogenetics in multiple myeloma. (16781866)
2006
36
Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation. (16995883)
2006
37
Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells. (15813853)
2005
38
Polymorphisms of glutathione S-transferase mu1 (GSTM1) and theta1 (GSTT1) genes in multiple myeloma. (12624497)
2003
39
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. (12010810)
2002
40
Recurrence of prostate adenocarcinoma presenting with multiple myeloma simulating skeletal metastases of prostate adenocarcinoma. (12475684)
2002
41
Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. (10753844)
2000
42
Factors influencing G-CSF-mediated mobilization of hematopoietic progenitor cells during steady-state hematopoiesis in patients with malignant lymphoma and multiple myeloma. (10550556)
1999
43
Role of interleukin-6 in the pathogenesis of murine plasmacytoma and human multiple myeloma. (9284811)
1997
44
Evaluation of treatment of anemia with erythropoietin in patients with multiple myeloma]. (8553596)
1995
45
Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. (7605999)
1995
46
Intensive sequential therapy for VAD-resistant multiple myeloma. (7915163)
1994
47
Characterization of bone marrow stromal cells from multiple myeloma. (7934143)
1994
48
New agents for the treatment of multiple myeloma and non-Hodgkin lymphoma. (1638466)
1992
49
Biology and treatment of multiple myeloma. (1591296)
1992
50
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome. (3083799)
1986

Genetic Variations for Multiple Myeloma

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Expression for genes affiliated with Multiple Myeloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Myeloma

Search GEO for disease gene expression data for Multiple Myeloma.

Pathways for genes affiliated with Multiple Myeloma

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53Reactome, 12EMD Millipore
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Pathways related to Multiple Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Oncostatin M signaling via JAK-Stat in human cells
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11.0IL6R, CCND1

Compounds for genes affiliated with Multiple Myeloma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR
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Compounds related to Multiple Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thalidomide44 49 59 1114.1IL6R, DKK1, CCND1
2baff2811.0TNFRSF17, TNFRSF13C
3blys4411.0TNFRSF17, TNFRSF13C
4bcma4410.7TNFRSF17, TNFRSF13C

GO Terms for genes affiliated with Multiple Myeloma

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16Gene Ontology
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Cellular components related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endomembrane systemGO:01250511.2NBEA, LECT1, TNFRSF17

Biological processes related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:01016511.0LIG4, CCND1

Molecular functions related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.5WHSC1, CCND1, PDZK1, IRF4, APOA1, LIG4

Products for genes affiliated with Multiple Myeloma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet