MCID: MLT019
MIFTS: 82

Multiple Myeloma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases categories

Summaries for Multiple Myeloma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss repeated infections frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma. An important gene associated with Multiple Myeloma is IRF4 (interferon regulatory factor 4). The drugs cyclophosphamide and thalidomide and the compounds guanidine and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:9 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:44 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys.Ā multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

Wikipedia:66 Plasma cell myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as multiple myeloma or Kahler\'s... more...

Description from OMIM:48 254500

Aliases & Classifications for Multiple Myeloma

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 50Orphanet, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 23GTR, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 37MESH via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
multiple myeloma:
Prevalence: 1-5/10000; Age of onset: Adulthood
primary amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

multiple myeloma 9 10 44 48 11 50 35 32 63
plasma cell myeloma 44 46 50
primary systemic amyloidosis 50 63
medullary plasmacytoma 50 63
plasma cell dyscrasia 44 63
primary amyloidosis 50 63
myeloma - multiple 44 23
myelomatosis 44 50
systemic immunoglobulinic amyloidosis 50
immunoglobulin deposition disease 63
immunoglobulinic amyloidosis 50
systemic al amyloidosis 50
light-chain amyloidosis 50
kahler's disease 50
al amyloidosis 50
kahler disease 44


External Ids:

Disease Ontology9 DOID:9538
MeSH36 D009101
OMIM48 254500
NCIt41 C3242
ICD9CM28 203.0
ICD10 via Orphanet27 E85.0, E85.1, E85.2 E85.3, C90.0, E85.8, more
SNOMED-CT via Orphanet60 23132008, 109989006, 55921005
MESH via Orphanet37 D009101, C531616
UMLS via Orphanet64 C0026764, C0268381
ICD1026 C90.0

Related Diseases for Multiple Myeloma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Multiple Myeloma:



Diseases related to multiple myeloma

Symptoms for Multiple Myeloma

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48OMIM
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Symptoms by clinical synopsis from OMIM:

254500

Clinical features from OMIM:

254500

Drugs & Therapeutics for Multiple Myeloma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Genetic Tests for Multiple Myeloma

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23GTR
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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma23

Anatomical Context for Multiple Myeloma

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards, 15FMA
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MalaCards organs/tissues related to Multiple Myeloma:

34
Bone, Bone marrow, Kidney, Testes, Endothelial, B cells, T cells, Testis, Lung, Myeloid, Breast, Skin, Nk cells, Liver, Prostate, Pituitary, Monocytes, Heart, Whole blood, Spinal cord, Thyroid, Tongue, Pancreas, Colon, Skeletal muscle, Brain, Lymph node

FMA organs/tissues related to Multiple Myeloma:

15
The plasma cells in bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Multiple Myeloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.0RASD1, PDZK1, IL6R, CCND1, DKK1, LIG4

Publications for Multiple Myeloma

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53PubMed
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Articles related to Multiple Myeloma:

(show top 50)    (show all 2817)
idTitleAuthorsYear
1
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
2
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
2013
3
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
2013
4
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
2013
5
Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma. (23758184)
2013
6
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
2012
7
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
2012
8
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. (23087808)
2012
9
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
2011
10
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
11
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
12
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
2010
13
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
2010
14
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
2009
15
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
2008
16
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
17
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. (18182077)
2008
18
CD117 (c-kit) is aberrantly expressed in a subset of MGUS and multiple myeloma with unexpectedly good prognosis. (17767956)
2008
19
A role for IFN-lambda1 in multiple myeloma B cell growth. (18830264)
2008
20
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
2007
21
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. (17173546)
2007
22
Chemokines in multiple myeloma. (16982321)
2006
23
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
2006
24
Differential expression of vascular endothelial growth factors and their receptors in multiple myeloma. (16870555)
2006
25
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
26
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
2005
27
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
28
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
2004
29
Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. (14977852)
2004
30
Characterization of clonogenic multiple myeloma cells. (14630803)
2004
31
DNA methylation changes in multiple myeloma. (15318245)
2004
32
Advances in biology and therapy of multiple myeloma. (14633785)
2003
33
Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. (12930383)
2003
34
Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (11841448)
2002
35
Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. (12492118)
2002
36
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
37
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
2000
38
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
1998
39
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
40
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
1997
41
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
42
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
43
Interferon-gamma in multiple myeloma. (8535185)
1995
44
Interferon-alpha-2b with VMCP for induction in multiple myeloma: the Israel Myeloma Cooperative Group experience. (7591683)
1995
45
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
1994
46
Objective response of multiple myeloma to cyclosporin A. (7696923)
1994
47
Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up. (8222376)
1993
48
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
1992
49
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
1991
50
Panhypopituitarism due to multiple myeloma. (5415797)
1970

Variations for Multiple Myeloma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Multiple Myeloma:

1
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
3FGFR3FGFR3, FGFR3/IGH FUSIONundetermined variantPathogenic

Expression for genes affiliated with Multiple Myeloma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Myeloma

Search GEO for disease gene expression data for Multiple Myeloma.

Pathways for genes affiliated with Multiple Myeloma

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Compounds for genes affiliated with Multiple Myeloma

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Multiple Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanidine46 25 1212.4APOA1, LECT1
2thalidomide46 52 62 1213.0IL6R, CCND1, DKK1

GO Terms for genes affiliated with Multiple Myeloma

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17Gene Ontology
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Cellular components related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.0RASD1, PDZK1, IL6R, DKK1, LIG4, FCRL4

Biological processes related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:01016510.4CCND1, LIG4

Molecular functions related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:01989910.3IL6R, CCND1, APOA1
2protein bindingGO:0055159.6WHSC1, DAZAP2, C1orf35, APOA1, FCRL4, LIG4

Products for genes affiliated with Multiple Myeloma

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  • Antibodies
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  • Antibodies

Sources for Multiple Myeloma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet