MCID: MLT019
MIFTS: 88

Multiple Myeloma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases categories
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Summaries for Multiple Myeloma

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MedlinePlus:33 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma, and has symptoms including An important gene associated with Multiple Myeloma is IRF4 (interferon regulatory factor 4). The drugs cyclophosphamide and thalidomide and the compounds guanidine and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotypes are tumorigenesis and immune system.

Disease Ontology:8 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:42 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys. multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

Wikipedia:65 Multiple myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as plasma cell myeloma,... more...

Description from OMIM:46 254500

Aliases & Classifications for Multiple Myeloma

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 62UMLS, 44Novoseek, 22GTR, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Multiple Myeloma, Aliases & Descriptions:

Name: Multiple Myeloma 30 8 9 42 46 10 48 33 62
Plasma Cell Myeloma 8 42 44 48
Primary Systemic Amyloidosis 48 62
Medullary Plasmacytoma 48 62
Plasma Cell Dyscrasia 42 62
Primary Amyloidosis 48 62
Myeloma - Multiple 42 22
Al Amyloidosis 48 62
 
Myelomatosis 42 48
Systemic Immunoglobulinic Amyloidosis 48
Immunoglobulinic Amyloidosis 48
Light-Chain Amyloidosis 48
Systemic Al Amyloidosis 48
Myeloma, Plasma-Cell 62
Kahler's Disease 48
Kahler Disease 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
multiple myeloma:
Prevalence: 1-5/10000; Age of onset: Adulthood
primary amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:9538
OMIM46 254500
ICD9CM27 203.0
MeSH34 D009101
NCIt39 C3242
ICD10 via Orphanet26 E85.0, E85.1, E85.2 E85.3, C90.0, E85.8, more
UMLS via Orphanet63 C0026764, C0268381
MESH via Orphanet35 D009101, C531616
ICD1025 C90.0

Related Diseases for Multiple Myeloma

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Diseases in the Multiple Myeloma family:

Myeloma Familial Myeloma

Diseases related to Multiple Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 468)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma32.7IL6R, WHSC1, CCND1, DKK1, IRF4, MYEOV
2plasmacytoma31.9IL6R, IRF4
3leukemia31.5IRF4, FGFR3, IL6R, LIG4, CCND1
4hodgkin's lymphoma31.3FGFR3, IRF4, IL6R
5non-hodgkin lymphoma31.1CCND1, IL6R, IRF4
6malt lymphoma30.6IRF4, CCND1
7prostate cancer30.6DKK1, LIG4, CCND1, IL6R, FGFR3
8amyloidosis10.8
9plasma cell leukemia10.8
10endotheliitis10.8
11hematopoietic stem cell transplantation10.7
12al amyloidosis10.6
13extramedullary plasmacytoma10.6
14macroglobulinemia10.6
15neuropathy10.6
16chronic lymphocytic leukemia10.6
17glomerulonephritis10.5
18cutis laxa10.5
19macroglobulinemia, waldenstrom, somatic10.5IRF4, CCND1
20pleomorphic adenoma10.5LECT1
21peripheral neuropathy10.5
22purpura10.5
23light chain deposition disease10.5
24acquired cutis laxa10.5
25cryoglobulinemia10.5
26hepatitis10.4
27myelodysplastic syndromes10.4
28hypercalcemia10.4
29acute leukemia10.4
30osteonecrosis10.4
31fanconi syndrome10.4
32myeloid leukemia10.4
33osteonecrosis of the jaw10.4
34arthritis10.4
35osteosclerosis10.4
36prostatitis10.4
37essential thrombocythemia10.4
38necrobiotic xanthogranuloma10.4
39acute myeloid leukemia10.4
40keratopathy10.4
41poems syndrome10.4
42gaucher's disease10.4
43kidney disease10.4
44amyloid neuropathy10.4
45scleredema10.4
46thromboembolism10.4
47angiodysplasia10.3
48pure red-cell aplasia10.3
49von willebrand's disease10.3
50neutropenia10.3

Graphical network of the top 20 diseases related to Multiple Myeloma:



Diseases related to multiple myeloma

Symptoms for Multiple Myeloma

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Symptoms by clinical synopsis from OMIM:

254500

Clinical features from OMIM:

254500

HPO human phenotypes related to Multiple Myeloma:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 somatic mutation HP:0001428
3 abnormality of metabolism/homeostasis HP:0001939
4 multiple myeloma HP:0006775

Drugs & Therapeutics for Multiple Myeloma

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Genetic Tests for Multiple Myeloma

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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma22

Anatomical Context for Multiple Myeloma

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MalaCards organs/tissues related to Multiple Myeloma:

32
Bone, Bone marrow, Kidney, Testes, Endothelial, B cells, T cells, Lung, Testis, Myeloid, Breast, Neutrophil, Liver, Skin, Nk cells, Prostate, Pituitary, Whole blood, Heart, Monocytes, Spinal cord, Thyroid, Tongue, Lymph node, Brain, Skeletal muscle, Colon, Pancreas

FMA organs/tissues related to Multiple Myeloma:

14
The plasma cells in bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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MGI Mouse Phenotypes related to Multiple Myeloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.3LIG4, FGFR3, IL6R, CCND1, IRF4
2MP:000538710.2IL6R, LECT1, APOA1, LIG4, IRF4, FGFR3
3MP:000538210.2FGFR3, WHSC1, CCND1, DKK1, LIG4
4MP:000537610.1IL6R, DKK1, PDZK1, RASD1, FGFR3, LIG4
5MP:00053979.9IRF4, APOA1, CCND1, IL6R, FGFR3, LECT1

Publications for Multiple Myeloma

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Articles related to Multiple Myeloma:

(show top 50)    (show all 2916)
idTitleAuthorsYear
1
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
2014
2
Treatment of multiple myeloma bone disease: experimental and clinical data. (25388648)
2014
3
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
4
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
2013
5
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
2013
6
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
2013
7
Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. (23446999)
2013
8
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
2013
9
Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma. (23758184)
2013
10
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
2012
11
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
2012
12
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. (23087808)
2012
13
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
2011
14
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
15
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
16
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
2010
17
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
2010
18
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
2009
19
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
2008
20
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
21
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. (18182077)
2008
22
CD117 (c-kit) is aberrantly expressed in a subset of MGUS and multiple myeloma with unexpectedly good prognosis. (17767956)
2008
23
A role for IFN-lambda1 in multiple myeloma B cell growth. (18830264)
2008
24
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
2007
25
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. (17173546)
2007
26
Chemokines in multiple myeloma. (16982321)
2006
27
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
2006
28
Differential expression of vascular endothelial growth factors and their receptors in multiple myeloma. (16870555)
2006
29
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
30
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
2005
31
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
32
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
2004
33
Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. (14977852)
2004
34
Characterization of clonogenic multiple myeloma cells. (14630803)
2004
35
Advances in biology and therapy of multiple myeloma. (14633785)
2003
36
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
37
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
2000
38
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
1998
39
Interleukin-2-mediated modulation of plasma cell tumor growth in a model of multiple myeloma. (9458238)
1998
40
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
41
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
1997
42
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
43
Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. (8617307)
1996
44
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
45
Interferon-gamma in multiple myeloma. (8535185)
1995
46
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
1994
47
Objective response of multiple myeloma to cyclosporin A. (7696923)
1994
48
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
1992
49
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
1991
50
Panhypopituitarism due to multiple myeloma. (5415797)
1970

Variations for Multiple Myeloma

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Clinvar genetic disease variations for Multiple Myeloma:

6
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
3FGFR3FGFR3, FGFR3/IGH FUSIONundetermined variantPathogenic

Expression for genes affiliated with Multiple Myeloma

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Expression patterns in normal tissues for genes affiliated with Multiple Myeloma

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Pathways for genes affiliated with Multiple Myeloma

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Compounds for genes affiliated with Multiple Myeloma

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Compounds related to Multiple Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanidine44 24 1112.4APOA1, LECT1
2thalidomide44 50 61 1113.3FGFR3, IL6R, CCND1, DKK1
3pd 17307444 6111.3CCND1, FGFR3
4guanine44 24 1112.1FGFR3, CCND1, APOA1

GO Terms for genes affiliated with Multiple Myeloma

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Cellular components related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.1FGFR3, RASD1, PDZK1, IL6R, DKK1, LIG4

Biological processes related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:01016510.4LIG4, CCND1
2somatic stem cell maintenanceGO:03501910.4FGFR3, LIG4
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3FGFR3, IL6R
4negative regulation of transcription from RNA polymerase II promoterGO:00012210.0DKK1, CCND1, WHSC1, FGFR3

Molecular functions related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.9FGFR3, C1orf35, APOA1, FCRL4, LIG4, IRF4

Products for genes affiliated with Multiple Myeloma

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Sources for Multiple Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet