Multiple Myeloma malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases
50OMIM, 33LifeMap Discovery®, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 12diseasecard, 36MedlinePlus, 37MeSH, 66UMLS, 48Novoseek, 25GTR, 28ICD10, 30ICD9CM, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Multiple Myeloma:
Orphanet epidemiological data:52
primary systemic amyloidosis:
Inheritance: Not applicable
Prevalence: 1-9/100000 (United States),1-9/100000 (Worldwide),1-5/10000 (Europe),1-9/100000 (France),1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Adult
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases
ICD10: 29 28
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
Rare neurological diseases
Rare renal diseases
Rare systemic and rhumatological diseases
Rare haematological diseases
NIH Rare Diseases:46 Multiple myeloma is a form of cancer that occurs due to abnormal and uncontrolled growth of plasma cells in the bone marrow. some people with multiple myeloma, especially those with early stages of the condition, have no concerning signs or symptoms. when present, the most common symptom is anemia, which can be associated with fatigue and shortness of breath. other features of the condition may include multiple infections; abnormal bleeding; bone pain; weak and/or easily broken bones; and numbness and/or weakness of the arms and legs. the exact underlying cause of multiple myeloma is currently unknown. factors that are associated with an increased risk of developing multiple myeloma include increasing age, male sex, african american race, radiation exposure, a family history of the condition, obesity, and/or a personal history of monoclonal gammopathy of undetermined significance (mgus). treatment varies based on many factors, but may include one or more of the following interventions: chemotherapy, corticosteroid medications, targeted therapy, stem cell transplant, biological therapy, radiation therapy, surgery and/or watchful waiting. last updated: 3/12/2016
MalaCards based summary: Multiple Myeloma, also known as plasma cell myeloma, is related to hemolytic anemia and igh-related multiple myeloma, and has symptoms including hepatomegaly, Array and Array. An important gene associated with Multiple Myeloma is LIG4 (DNA Ligase 4), and among its related pathways are Cytokine production by Th17 cells in CF and Allograft rejection. The drugs cyclophosphamide and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotypes are neoplasm and growth/size/body region.
Disease Ontology:11 A myeloma that is located in the plasma cells in bone marrow.
UniProtKB/Swiss-Prot:68 Multiple myeloma: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
MedlinePlus:36 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute
Genetics Home Reference:24 Multiple myeloma is a cancer that develops in the bone marrow, the spongy tissue found in the center of most bones. The bone marrow produces red blood cells, which carry oxygen throughout the body; white blood cells, which form the body's defenses (immune system); and platelets, which are necessary for blood clotting.
OMIM:50 Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells... (254500) more...
Wikipedia:69 Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood... more...
Symptoms by clinical synopsis from OMIM:254500
Clinical features from OMIM:254500
Symptoms:52 (show all 59)
UMLS symptoms related to Multiple Myeloma:hepatomegaly
FDA approved drugs:(show all 17)
Drugs for Multiple Myeloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 347)
Interventional clinical trials:(show top 50) (show all 2166)
Search NIH Clinical Center for Multiple Myeloma
Inferred drug relations via UMLS66/NDF-RT44:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Multiple Myeloma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Myeloma:
Embryonic/Adult Cultured Cells Related to Multiple Myeloma:
MalaCards organs/tissues related to Multiple Myeloma:34
Bone, Bone marrow, T cells, B cells, Testes, Kidney, Breast
FMA organs/tissues related to Multiple Myeloma:17
The plasma cells in bone marrow
Data from LifeMap, the Embryonic Development and Stem Cells Database
Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
Articles related to Multiple Myeloma:(show top 50) (show all 3308)
Clinvar genetic disease variations for Multiple Myeloma:5
Copy number variations for Multiple Myeloma from CNVD:6 (show top 50) (show all 302)
Search GEO for disease gene expression data for Multiple Myeloma.
Pathways related to Multiple Myeloma according to GeneCards Suite gene sharing:
Cellular components related to Multiple Myeloma according to GeneCards Suite gene sharing:
Biological processes related to Multiple Myeloma according to GeneCards Suite gene sharing:(show all 8)
Molecular functions related to Multiple Myeloma according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet