Multiple Myeloma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Blood diseases categories

Aliases & Classifications for Multiple Myeloma

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46OMIM, 30LifeMap Discovery®, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 32MedlinePlus, 61UMLS, 44Novoseek, 22GTR, 56SNOMED-CT, 27ICD9CM, 39NCIt, 33MeSH, 62UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Multiple Myeloma:

Name: Multiple Myeloma 46 30 8 9 42 10 48 32 61
Plasma Cell Myeloma 8 42 44 48
Medullary Plasmacytoma 42 48 61
Plasma Cell Dyscrasia 42 61
Myeloma - Multiple 42 22
Myelomatosis 42 48
Myeloma, Multiple Amyloidosis, Systemic, Included 46
Kahler's Disease 48
Kahlers Disease 42
Kahler Disease 42


Characteristics (Orphanet epidemiological data):

multiple myeloma:
Prevalence: 1-9/100000 (United States),1-9/100000 (Worldwide),1-5/10000 (Europe),1-9/100000 (France),1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Adult

External Ids:

OMIM46 254500
Disease Ontology8 DOID:9538
ICD9CM27 203.0
NCIt39 C3242
MeSH33 D009101
Orphanet48 29073
UMLS via Orphanet62 C0026764
MESH via Orphanet34 D009101
ICD10 via Orphanet26 C90.0
ICD1025 C90.0

Summaries for Multiple Myeloma

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MedlinePlus:32 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma, and has symptoms including autosomal recessive inheritance, somatic mutation and abnormality of metabolism/homeostasis. An important gene associated with Multiple Myeloma is CCND1 (cyclin D1). The drugs thalidomide and carmustine and the compounds pd 173074 and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotypes are craniofacial and tumorigenesis.

Disease Ontology:8 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:42 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys. multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

OMIM:46 Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells... (254500) more...

Wikipedia:64 Multiple myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as plasma cell myeloma,... more...

Related Diseases for Multiple Myeloma

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Diseases in the Myeloma family:

multiple myeloma Familial Myeloma

Diseases related to Multiple Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 395)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma32.8MYEOV, IRF4, DKK1, CCND1, IL6R, WHSC1
2plasmacytoma31.8IL6R, IRF4
3leukemia31.6LIG4, IRF4, CCND1, IL6R, FGFR3
4waldenstrom macroglobulinemia31.1CCND1, IRF4
5hodgkin lymphoma31.1IRF4, IL6R, FGFR3
6prostate cancer30.7LIG4, DKK1, CCND1, IL6R, FGFR3
7malt lymphoma30.6CCND1, IRF4
8burkitt lymphoma30.3LIG4, IRF4, CCND1, IL6R, FGFR3
10plasma cell leukemia10.8
12hematopoietic stem cell transplantation10.7
13extramedullary plasmacytoma10.7
14al amyloidosis10.7
17chronic lymphocytic leukemia10.5
19cutis laxa10.5
20peripheral neuropathy10.5
22pleomorphic adenoma10.5LECT1
23light chain deposition disease10.5
24acquired cutis laxa10.5
26myelodysplastic syndrome10.5
27acute leukemia10.5
28fanconi syndrome10.5
32myeloid leukemia10.4
33necrobiotic xanthogranuloma10.4
34osteonecrosis of the jaw10.4
36essential thrombocythemia10.4
37insulin-like growth factor i10.4
40gaucher's disease10.4
41poems syndrome10.4
42kidney disease10.4
43amyloid neuropathy10.4
47von willebrand's disease10.4
48lymphoma, non-hodgkin10.3IRF4, CCND1, IL6R
50thrombotic thrombocytopenic purpura10.3

Graphical network of the top 20 diseases related to Multiple Myeloma:

Diseases related to multiple myeloma

Symptoms for Multiple Myeloma

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Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:


HPO human phenotypes related to Multiple Myeloma:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 somatic mutation HP:0001428
3 abnormality of metabolism/homeostasis HP:0001939
4 multiple myeloma HP:0006775

Drugs & Therapeutics for Multiple Myeloma

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FDA approved drugs:

(show all 9)
id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
Aredia13 38 PAMIDRONATE DISODIUM Chiron Approved August 1996
FDA Label: Aredia
Malady that Drug Treats: osteolytic bone metastases of breast cancer
Indications and Usage:13 Hypercalcemia of Malignancy; Aredia, in conjunction with adequate hydration, is indicated for the treatment of moderate or severe; hypercalcemia associated with malignancy, with or without bone metastases. Patients who have either; epidermoid or non-epidermoid tumors respond to treatment with Aredia. Vigorous saline hydration, an; integral part of hypercalcemia therapy, should be initiated promptly and an attempt should be made to; restore the urine output to about 2 L/day throughout treatment. Mild or asymptomatic hypercalcemia may; be treated with conservative measures (i.e., saline hydration, with or without loop diuretics). Patients; should be hydrated adequately throughout the treatment, but overhydration, especially in those patients; who have cardiac failure, must be avoided. Diuretic therapy should not be employed prior to correction of; hypovolemia. The safety and efficacy of Aredia in the treatment of hypercalcemia associated with; hyperparathyroidism or with other non-tumor-related conditions has not been established.; Paget s Disease; Aredia is indicated for the treatment of patients with moderate to severe Paget s disease of bone. The; effectiveness of Aredia was demonstrated primarily in patients with serum alkaline phosphatase e"3 times; the upper limit of normal. Aredia therapy in patients with Paget s disease has been effective in reducing; serum alkaline phosphatase and urinary hydroxyproline levels by e"50% in at least 50% of patients, and by; e"30% in at least 80% of patients. Aredia therapy has also been effective in reducing these biochemical; markers in patients with Paget s disease who failed to respond, or no longer responded to other; treatments.; Osteolytic Bone Metastases of Breast Cancer and Osteolytic Lesions of Multiple; Myeloma; Aredia is indicated, in conjunction with standard antineoplastic therapy, for the treatment of osteolytic; bone metastases of breast cancer and osteolytic lesions of multiple myeloma. The Aredia treatment effect; appeared to be smaller in the study of breast cancer patients receiving hormonal therapy than in the study; of those receiving chemotherapy, however, overall evidence of clinical benefit has been demonstrated; (see CLINICAL PHARMACOLOGY, Osteolytic Bone Metastases of Breast Cancer and Osteolytic; Lesions of Multiple Myeloma, Clinical Trials section).
DrugBank Targets:11 1. Farnesyl pyrophosphate synthase; 2. Hydroxylapatite
Mechanism of Action:13 
Target: bone resorption; FPP synthase
Action: inhibitor
FDA: The principal pharmacologic action of Aredia is inhibition of bone resorption. Although the mechanism of; antiresorptive action is not completely understood, several factors are thought to contribute to this action.; Aredia adsorbs to calcium phosphate (hydroxyapatite) crystals in bone and may directly block dissolution; of this mineral component of bone. In vitro studies also suggest that inhibition of osteoclast activity; contributes to inhibition of bone resorption. In animal studies, at doses recommended for the treatment of; hypercalcemia, Aredia inhibits bone resorption apparently without inhibiting bone formation and; mineralization. Of relevance to the treatment of hypercalcemia of malignancy is the finding that Aredia; inhibits the accelerated bone resorption that results from osteoclast hyperactivity induced by various; tumors in animal studies.
Doxil13 38 DOXORUBICIN HYDROCHLORIDE Alza Approved June 1999
FDA Label: Doxil
Malady that Drug Treats: ovarian cancer that is refractory to other first-line therapies
Indications and Usage:13 DOXIL is an anthracycline topoisomerase II inhibitor indicated for:; Ovarian cancer (1.1); After failure of platinum-based chemotherapy.; AIDS-related Kaposi s Sarcoma (1.2); After failure of prior systemic chemotherapy or intolerance to such therapy.; Multiple Myeloma (1.3); In combination with bortezomib in patients who have not previously; received bortezomib and have received at least one prior therapy.
DrugBank Targets:11 1. DNA; 2. DNA topoisomerase 2-alpha
Mechanism of Action:13 
Target: nucleic acid; synthesis
Action: inhibitor
FDA: The active ingredient of DOXIL is doxorubicin HCl. The mechanism of action of; doxorubicin HCl is thought to be related to its ability to bind DNA and inhibit nucleic acid; synthesis. Cell structure studies have demonstrated rapid cell penetration and perinuclear; Reference ID: 3733596; 17 ; ; ; ; ; chromatin binding, rapid inhibition of mitotic activity and nucleic acid synthesis, and; induction of mutagenesis and chromosomal aberrations.
Farydak13 38 PANOBINOSTAT LACTATE Novartis Approved February 2015
FDA Label: Farydak
Malady that Drug Treats: Multiple myeloma
Indications and Usage:13 FARYDAK, a histone deacetylase inhibitor, in combination with bortezomib; and dexamethasone, is indicated for the treatment of patients with multiple; myeloma who have received at least 2 prior regimens, including bortezomib; and an immunomodulatory agent. This indication is approved under; accelerated approval based on progression free survival. Continued approval; for this indication may be contingent upon verification and description of; clinical benefit in confirmatory trials. (1)
DrugBank Targets: -
Mechanism of Action:13 
Target: histone deacetylase (HDAC)
Action: inhibitor
FDA: FARYDAK is a histone deacetylase (HDAC) inhibitor that inhibits the enzymatic activity of HDACs at; nanomolar concentrations. HDACs catalyze the removal of acetyl groups from the lysine residues of histones; and some non-histone proteins. Inhibition of HDAC activity results in increased acetylation of histone proteins,; an epigenetic alteration that results in a relaxing of chromatin, leading to transcriptional activation. In vitro,; Reference ID: 3699607 ; ; panobinostat caused the accumulation of acetylated histones and other proteins, inducing cell cycle arrest and/or; apoptosis of some transformed cells. Increased levels of acetylated histones were observed in xenografts from; mice that were treated with panobinostat. Panobinostat shows more cytotoxicity towards tumor cells compared; to normal cells.
Kyprolis13 38 CARFILZOMIB Onyx Pharmaceuticals Approved July 2012
FDA Label: Kyprolis
Malady that Drug Treats: multiple myeloma
Indications and Usage:13 Kyprolis is a proteasome inhibitor that is indicated; in combination with lenalidomide and dexamethasone for the treatment of; patients with relapsed multiple myeloma who have received one to three; prior lines of therapy . (1, 14); as a single agent for the treatment of patients with multiple myeloma who; have received at least two prior therapies including bortezomib and an; immunomodulatory agent and have demonstrated disease progression on or; within 60 days of completion of the last therapy. Approval is based on; response rate. Clinical benefit, such as improvement in survival or; symptoms, has not been verified. (1, 14)
DrugBank Targets:11 1. Proteasome subunit beta type-5; 2. Proteasome subunit beta type-8; 3. Proteasome subunit beta type-1; 4. Proteasome subunit beta type-9; 5. Proteasome subunit beta type-2; 6. Proteasome subunit beta type-10
Mechanism of Action:13 
Target: tetrapeptide epoxyketone proteasome
Action: inhibitor
FDA: Carfilzomib is a tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds to the; N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core; particle within the 26S proteasome. Carfilzomib had antiproliferative and proapoptotic; activities in vitro in solid and hematologic tumor cells. In animals, carfilzomib inhibited; proteasome activity in blood and tissue and delayed tumor growth in models of multiple; myeloma, hematologic, and solid tumors.
Mozobil13 38 PLERIXAFOR Genzyme Approved December 2008
FDA Label: Mozobil
Malady that Drug Treats: non-Hodgkin s lymphoma and multiple myeloma
Indications and Usage:13 Mozobil, a hematopoietic stem cell mobilizer, is indicated in combination; with granulocyte-colony stimulating factor (G-CSF) to mobilize; hematopoietic stem cells (HSCs) to the peripheral blood for collection and; subsequent autologous transplantation in patients with non-Hodgkin s; lymphoma and multiple myeloma. (1)
DrugBank Targets:11 1. C-X-C chemokine receptor type 4
Mechanism of Action:13 
Target: hematopoietic stem cell/ CXCR4 chemokine receptor
Action: monilizer/ inhibitor
FDA: Plerixafor is an inhibitor of the CXCR4 chemokine receptor and blocks binding of its cognate; ligand, stromal cell-derived factor-1± (SDF-1±). SDF-1± and CXCR4 are recognized to play a; role in the trafficking and homing of human hematopoietic stem cells (HSCs) to the marrow; compartment. Once in the marrow, stem cell CXCR4 can act to help anchor these cells to the; marrow matrix, either directly via SDF-1± or through the induction of other adhesion molecules.; Treatment with plerixafor resulted in leukocytosis and elevations in circulating hematopoietic; progenitor cells in mice, dogs and humans. CD34+ cells mobilized by plerixafor were capable of; engraftment with long-term repopulating capacity up to one year in canine transplantation; models.
Pomalyst13 38 POMALIDOMIDE Celgene Approved February 2013
FDA Label: Pomalyst
Malady that Drug Treats: relapsed and refractory multiple myeloma
Indications and Usage:13 POMALYST is a thalidomide analogue indicated, in combination with; dexamethasone, for patients with multiple myeloma who have received at; least two prior therapies including lenalidomide and a proteasome inhibitor; and have demonstrated disease progression on or within 60 days of; completion of the last therapy (1.1).
DrugBank Targets:11 1. Protein cereblon; 2. Tumor necrosis factor; 3. Prostaglandin G/H synthase 2
Mechanism of Action:13 
Target: hematopoietic tumor cells, lenalidomide-resistant multiple myeloma cell lines/ T-cells
Action: inhibitor of proliferation/ inducer of apoptosis/ enhancer of natural killer cell-mediated immunity
FDA: Pomalidomide, an analogue of thalidomide, is an immunomodulatory agent with antineoplastic; activity. In in vitro cellular assays, pomalidomide inhibited proliferation and induced apoptosis of hematopoietic tumor cells. Additionally, pomalidomide inhibited the proliferation of; lenalidomide-resistant multiple myeloma cell lines and synergized with dexamethasone in both; lenalidomide-sensitive and lenalidomide-resistant cell lines to induce tumor cell apoptosis.; Pomalidomide enhanced T cell- and natural killer (NK) cell-mediated immunity and inhibited; production of pro-inflammatory cytokines (e.g., TNF-± and IL-6) by monocytes. Pomalidomide; demonstrated anti-angiogenic activity in a mouse tumor model and in the in vitro umbilical cord; model.
Revlimid13 38 LENALIDOMIDE Celgene Approved June 2013
FDA Label: Revlimid
Malady that Drug Treats: mantle cell lymphoma
Indications and Usage:13 REVLIMID is a thalidomide analogue indicated for the treatment of patients; with:; Multiple myeloma (MM), in combination with dexamethasone (1.1).; Transfusion-dependent anemia due to low- or intermediate-1-risk; myelodysplastic syndromes (MDS) associated with a deletion 5q; abnormality with or without additional cytogenetic abnormalities (1.2).; Mantle cell lymphoma (MCL) whose disease has relapsed or progressed; after two prior therapies, one of which included bortezomib (1.3).; Limitations of Use:; REVLIMID is not indicated and is not recommended for the treatment; of patients with chronic lymphocytic leukemia (CLL) outside of; controlled clinical trials (1.4).
DrugBank Targets:11 1. Protein cereblon; 2. Tumor necrosis factor ligand superfamily member 11; 3. Cadherin-5; 4. Prostaglandin G/H synthase 2
Mechanism of Action:13 
Target: T cells and natural killer cells/ pro-inflammatory cytokines by monocytes
Action: activator/inhibitor
FDA: Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. Lenalidomide inhibits; proliferation and induces apoptosis of certain hematopoietic tumor cells including multiple myeloma, mantle cell lymphoma, and del (5q); myelodysplastic syndromes in vitro. Lenalidomide causes a delay in tumor growth in some in vivo nonclinical hematopoietic tumor models; including multiple myeloma. Immunomodulatory properties of lenalidomide include activation of T cells and natural killer (NK) cells, increased; numbers of NKT cells, and inhibition of pro-inflammatory cytokines (e.g., TNF-± and IL-6) by monocytes. In multiple myeloma cells, the; combination of lenalidomide and dexamethasone synergizes the inhibition of cell proliferation and the induction of apoptosis.
Velcade13 38 BORTEZOMIB Millennium Pharmaceuticals Approved May 2003
FDA Label: Velcade
Malady that Drug Treats: Multiple Myeloma
Indications and Usage:13 VELCADE is a proteasome inhibitor indicated for:; treatment of patients with multiple myeloma (1.1); treatment of patients with mantle cell lymphoma (1.2)
DrugBank Targets:11 1. 26S proteasome non-ATPase regulatory subunit 2; 2. 26S proteasome non-ATPase regulatory subunit 1; 3. Proteasome subunit beta type-1; 4. Proteasome subunit beta type-5; 5. Proteasome subunit beta type-2
Mechanism of Action:13 
Target: 26S proteasome
Action: reversible inhibitor of chymotrypsin-like activity
FDA: Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian; cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The ubiquitinproteasome; pathway plays an essential role in regulating the intracellular concentration of specific proteins,; thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome prevents this targeted; proteolysis, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic; mechanisms can lead to cell death. Experiments have demonstrated that bortezomib is cytotoxic to a variety of; cancer cell types in vitro. Bortezomib causes a delay in tumor growth in vivo in nonclinical tumor models,; including multiple myeloma.
Zometa13 38 ZOLEDRONIC ACID Novartis Approved August 2001/ Approved February 2002
FDA Label: Zometa
Malady that Drug Treats: Hypercalcemia of malignancy/ Multiple myeloma; bone metastases from solid tumors
Indications and Usage:13 Zometa is a bisphosphonate indicated for the treatment of:; Hypercalcemia of malignancy. (1.1); Patients with multiple myeloma and patients with documented bone; metastases from solid tumors, in conjunction with standard antineoplastic; therapy. Prostate cancer should have progressed after treatment with at; least one hormonal therapy. (1.2); Important limitation of use: The safety and efficacy of Zometa has not been; established for use in hyperparathyroidism or nontumor-related; hypercalcemia. (1.3)
DrugBank Targets:11 1. Farnesyl pyrophosphate synthase; 2. Geranylgeranyl pyrophosphate synthase; 3. Hydroxylapatite
Mechanism of Action:13 
Target: bone resorption
Action: inhibitor
FDA: The principal pharmacologic action of zoledronic acid is inhibition of bone resorption. Although the; antiresorptive mechanism is not completely understood, several factors are thought to contribute to this action.; In vitro, zoledronic acid inhibits osteoclastic activity and induces osteoclast apoptosis. Zoledronic acid also; blocks the osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid; inhibits the increased osteoclastic activity and skeletal calcium release induced by various stimulatory factors; released by tumors.

Drug clinical trials:

Search ClinicalTrials for Multiple Myeloma

Search NIH Clinical Center for Multiple Myeloma

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Multiple Myeloma cell therapies at LifeMap Discovery.

Genetic Tests for Multiple Myeloma

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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma22

Anatomical Context for Multiple Myeloma

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MalaCards organs/tissues related to Multiple Myeloma:

Bone, Bone marrow, Kidney, Testes, B cells, Endothelial, T cells, Lung, Testis, Myeloid, Breast, Nk cells, Liver, Skin, Neutrophil, Prostate, Pituitary, Whole blood, Heart, Monocytes, Spinal cord, Thyroid, Tongue, Lymph node, Brain, Skeletal muscle, Colon, Pancreas

FMA organs/tissues related to Multiple Myeloma:

The plasma cells in bone marrow

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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MGI Mouse Phenotypes related to Multiple Myeloma:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538210.2FGFR3, WHSC1, CCND1, DKK1, LIG4
2MP:00020069.9LIG4, IRF4, CCND1, IL6R, FGFR3
3MP:00053769.7FGFR3, LECT1, NBEA, LIG4, DKK1, CCND1

Publications for Multiple Myeloma

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Articles related to Multiple Myeloma:

(show top 50)    (show all 2950)
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis. (25898974)
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
Treatment of multiple myeloma bone disease: experimental and clinical data. (25388648)
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. (23446999)
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma. (23758184)
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. (23087808)
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. (18182077)
A role for IFN-lambda1 in multiple myeloma B cell growth. (18830264)
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. (17173546)
Chemokines in multiple myeloma. (16982321)
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. (14977852)
Characterization of clonogenic multiple myeloma cells. (14630803)
Advances in biology and therapy of multiple myeloma. (14633785)
Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (11841448)
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
Interleukin-2-mediated modulation of plasma cell tumor growth in a model of multiple myeloma. (9458238)
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. (8617307)
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
Interferon-gamma in multiple myeloma. (8535185)
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
Objective response of multiple myeloma to cyclosporin A. (7696923)
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
Panhypopituitarism due to multiple myeloma. (5415797)

Variations for Multiple Myeloma

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Clinvar genetic disease variations for Multiple Myeloma:

id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
3FGFR3FGFR3, FGFR3/IGH FUSIONundetermined variantPathogenic

Expression for genes affiliated with Multiple Myeloma

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Search GEO for disease gene expression data for Multiple Myeloma.

Pathways for genes affiliated with Multiple Myeloma

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Compounds for genes affiliated with Multiple Myeloma

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Compounds related to Multiple Myeloma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1pd 17307444 6011.4FGFR3, CCND1
2thalidomide44 50 60 1112.9FGFR3, IL6R, CCND1, DKK1

GO Terms for genes affiliated with Multiple Myeloma

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Cellular components related to Multiple Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058869.9FGFR3, RASD1, PDZK1, IL6R, DKK1, LIG4

Biological processes related to Multiple Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:001016510.4CCND1, LIG4
2somatic stem cell maintenanceGO:003501910.4FGFR3, LIG4
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.3FGFR3, IL6R
4negative regulation of transcription from RNA polymerase II promoterGO:00001229.9DKK1, CCND1, WHSC1, FGFR3

Molecular functions related to Multiple Myeloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055159.6FGFR3, C1orf35, FCRL4, LIG4, IRF4, DKK1

Sources for Multiple Myeloma

About this section
26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet