MCID: MLT019
MIFTS: 85

Multiple Myeloma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Blood diseases categories

Summaries for Multiple Myeloma

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MedlinePlus:34 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma, and has symptoms including autosomal recessive inheritance, somatic mutation and abnormality of metabolism/homeostasis. An important gene associated with Multiple Myeloma is CCND1 (cyclin D1). The drugs cyclophosphamide and thalidomide and the compounds pd 173074 and thalidomide have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotypes are craniofacial and tumorigenesis.

Disease Ontology:10 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:43 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys. multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

OMIM:47 Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells... (254500) more...

Wikipedia:65 Multiple myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as plasma cell myeloma,... more...

Aliases & Classifications for Multiple Myeloma

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Sources:
47OMIM, 32LifeMap Discovery®, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 12DISEASES, 49Orphanet, 34MedlinePlus, 62UMLS, 45Novoseek, 24GTR, 57SNOMED-CT, 29ICD9CM, 40NCIt, 35MeSH, 63UMLS via Orphanet, 36MESH via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all sources

Multiple Myeloma, Aliases & Descriptions:

Name: Multiple Myeloma 47 32 10 11 43 12 49 34 62
Plasma Cell Myeloma 10 43 45 49
Medullary Plasmacytoma 43 49 62
Plasma Cell Dyscrasia 43 62
Myeloma - Multiple 43 24
Myelomatosis 43 49
Myeloma, Multiple Amyloidosis, Systemic, Included 47
 
Primary Systemic Amyloidosis 62
Myeloma, Plasma-Cell 62
Primary Amyloidosis 62
Kahler's Disease 49
Kahlers Disease 43
Al Amyloidosis 62
Kahler Disease 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
multiple myeloma:
Prevalence: 1-9/100000 (United States),1-9/100000 (Worldwide),1-5/10000 (Europe),1-9/100000 (France),1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Adult


External Ids:

OMIM47 254500
Disease Ontology10 DOID:9538
ICD9CM29 203.0
NCIt40 C3242
MeSH35 D009101
Orphanet49 29073
UMLS via Orphanet63 C0026764
MESH via Orphanet36 D009101
ICD10 via Orphanet28 C90.0
ICD1027 C90.0

Related Diseases for Multiple Myeloma

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Diseases in the Myeloma family:

multiple myeloma Familial Myeloma

Diseases related to Multiple Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 395)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma32.6MYEOV, IRF4, DKK1, CCND1, IL6R, WHSC1
2plasmacytoma31.5IL6R, IRF4
3leukemia31.5LIG4, IRF4, CCND1, IL6R, FGFR3
4hodgkin lymphoma30.8IRF4, IL6R, FGFR3
5prostate cancer30.5LIG4, DKK1, CCND1, IL6R, FGFR3
6waldenstrom macroglobulinemia30.5CCND1, IRF4
7malt lymphoma30.0CCND1, IRF4
8burkitt lymphoma30.0LIG4, IRF4, CCND1, IL6R, FGFR3
9amyloidosis10.8
10plasma cell leukemia10.8
11endotheliitis10.8
12hematopoietic stem cell transplantation10.7
13extramedullary plasmacytoma10.7
14al amyloidosis10.7
15macroglobulinemia10.6
16neuropathy10.6
17chronic lymphocytic leukemia10.5
18glomerulonephritis10.5
19cutis laxa10.5
20peripheral neuropathy10.5
21purpura10.5
22light chain deposition disease10.5
23acquired cutis laxa10.5
24cryoglobulinemia10.5
25myelodysplastic syndrome10.5
26acute leukemia10.5
27fanconi syndrome10.5
28hypercalcemia10.5
29hepatitis10.4
30osteonecrosis10.4
31myeloid leukemia10.4
32necrobiotic xanthogranuloma10.4
33osteonecrosis of the jaw10.4
34prostatitis10.4
35essential thrombocythemia10.4
36insulin-like growth factor i10.4
37arthritis10.4
38keratopathy10.4
39gaucher's disease10.4
40poems syndrome10.4
41kidney disease10.4
42amyloid neuropathy10.4
43scleredema10.4
44hypoxia10.4
45angiodysplasia10.4
46von willebrand's disease10.4
47retinoblastoma10.3
48thrombotic thrombocytopenic purpura10.3
49herpes zoster10.3
50monoclonal gammopathy of uncertain significance10.3

Graphical network of the top 20 diseases related to Multiple Myeloma:



Diseases related to multiple myeloma

Symptoms for Multiple Myeloma

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Symptoms by clinical synopsis from OMIM:

254500

Clinical features from OMIM:

254500

HPO human phenotypes related to Multiple Myeloma:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 somatic mutation HP:0001428
3 abnormality of metabolism/homeostasis HP:0001939
4 multiple myeloma HP:0006775

Drugs & Therapeutics for Multiple Myeloma

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Genetic Tests for Multiple Myeloma

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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma24

Anatomical Context for Multiple Myeloma

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MalaCards organs/tissues related to Multiple Myeloma:

33
Bone, Bone marrow, Kidney, Testes, B cells, Endothelial, T cells, Lung, Testis, Myeloid, Breast, Nk cells, Liver, Skin, Neutrophil, Prostate, Pituitary, Whole blood, Heart, Monocytes, Spinal cord, Thyroid, Tongue, Lymph node, Brain, Skeletal muscle, Colon, Pancreas

FMA organs/tissues related to Multiple Myeloma:

16
The plasma cells in bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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MGI Mouse Phenotypes related to Multiple Myeloma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538210.2FGFR3, WHSC1, CCND1, DKK1, LIG4
2MP:00020069.9LIG4, IRF4, CCND1, IL6R, FGFR3
3MP:00053769.7FGFR3, LECT1, NBEA, LIG4, DKK1, CCND1

Publications for Multiple Myeloma

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Articles related to Multiple Myeloma:

(show top 50)    (show all 2950)
idTitleAuthorsYear
1
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis. (25898974)
2015
2
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
2014
3
Treatment of multiple myeloma bone disease: experimental and clinical data. (25388648)
2014
4
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells. (24396705)
2013
5
An old drug with a new future: bendamustine in multiple myeloma. (24053161)
2013
6
Cytogenetic classification in Korean multiple myeloma patients: Prognostic significance of hyperdiploidy with 47 to 50 chromosomes and the number of structural abnormalities. (24372944)
2013
7
How to determine bortezomib-based regimen for elderly patients with multiple myeloma: PAD versus CBd, an observational study. (24337419)
2013
8
Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. (23446999)
2013
9
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma-to strengthen the case toward renal replacement therapy? (25356216)
2013
10
Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma. (23758184)
2013
11
The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (22792345)
2012
12
Effects of short-hairpin RNA-inhibited I^-catenin expression on the growth of human multiple myeloma cells in vitro and in vivo. (22609776)
2012
13
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study. (23087808)
2012
14
Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells. (21420464)
2011
15
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. (21063407)
2010
16
Thrombotic thrombocytopenic purpura associated with disseminated varicella zoster in a multiple myeloma patient. (21260958)
2010
17
Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (19762082)
2010
18
Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death. (20920357)
2010
19
Potentiation of (-)-epigallocatechin-3-gallate-induced apoptosis by bortezomib in multiple myeloma cells. (20011976)
2009
20
MDR1 diplotypes as prognostic markers in multiple myeloma. (18408561)
2008
21
Tc-99m sestamibi uptake mimicking parathyroid adenoma in a patient with primary hyperparathyroidism and occult multiple myeloma. (18287846)
2008
22
High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. (18182077)
2008
23
A role for IFN-lambda1 in multiple myeloma B cell growth. (18830264)
2008
24
Patients with multiple myeloma treated with thalidomide: evaluation of clinical parameters, cytokines,angiogenic markers, mast cells and marrow CD57+ cytotoxic T cells as predictors of outcome. (17640854)
2007
25
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. (17173546)
2007
26
Chemokines in multiple myeloma. (16982321)
2006
27
The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma. (17043023)
2006
28
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
29
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. (15902294)
2005
30
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
31
The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma. (15629043)
2004
32
Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. (14977852)
2004
33
Characterization of clonogenic multiple myeloma cells. (14630803)
2004
34
Advances in biology and therapy of multiple myeloma. (14633785)
2003
35
Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. (11841448)
2002
36
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
37
Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. (11030205)
2000
38
CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. (9823960)
1998
39
Interleukin-2-mediated modulation of plasma cell tumor growth in a model of multiple myeloma. (9458238)
1998
40
Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. (9558394)
1998
41
Modulation of interleukin-6/interleukin-6 receptor cytokine loop in the treatment of multiple myeloma. (9373192)
1997
42
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. (9815779)
1997
43
Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. (8617307)
1996
44
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
45
Interferon-gamma in multiple myeloma. (8535185)
1995
46
Optimal blood stem cell mobilization using 10 micrograms/kg granulocyte colony-stimulating factor (G-CSF) alone for high-dose melphalan intensification in multiple myeloma: an intrapatient controlled study. (7522395)
1994
47
Objective response of multiple myeloma to cyclosporin A. (7696923)
1994
48
Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support. (1391937)
1992
49
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. (2031968)
1991
50
Panhypopituitarism due to multiple myeloma. (5415797)
1970

Variations for Multiple Myeloma

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Clinvar genetic disease variations for Multiple Myeloma:

7
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889
2FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
3FGFR3FGFR3, FGFR3/IGH FUSIONundetermined variantPathogenic

Expression for genes affiliated with Multiple Myeloma

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Search GEO for disease gene expression data for Multiple Myeloma.

Pathways for genes affiliated with Multiple Myeloma

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Compounds for genes affiliated with Multiple Myeloma

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Compounds related to Multiple Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pd 17307445 6111.4FGFR3, CCND1
2thalidomide45 51 61 1312.9FGFR3, IL6R, CCND1, DKK1

GO Terms for genes affiliated with Multiple Myeloma

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Cellular components related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058869.9FGFR3, RASD1, PDZK1, IL6R, DKK1, LIG4

Biological processes related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:001016510.4CCND1, LIG4
2somatic stem cell maintenanceGO:003501910.4FGFR3, LIG4
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.3FGFR3, IL6R
4negative regulation of transcription from RNA polymerase II promoterGO:00001229.9DKK1, CCND1, WHSC1, FGFR3

Molecular functions related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055159.6FGFR3, C1orf35, FCRL4, LIG4, IRF4, DKK1

Products for genes affiliated with Multiple Myeloma

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Sources for Multiple Myeloma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet