MCID: MLT019
MIFTS: 89

Multiple Myeloma malady

Cancer diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Blood diseases, Immune diseases categories

Summaries for Multiple Myeloma

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. these cells are part of your immune system, which helps protect the body from germs and other harmful substances. in time, myeloma cells collect in the bone marrow and in the solid parts of bones. no one knows the exact causes of multiple myeloma, but it is more common in older people and african americans. it can run in families. common symptoms may include bone pain, often in the back or ribs broken bones weakness or fatigue weight loss repeated infections frequent infections and fevers feeling very thirsty frequent urination doctors diagnose multiple myeloma using lab tests, imaging tests, and a bone marrow biopsy. your treatment depends on how advanced the disease is and whether you have symptoms. if you have no symptoms, you may not need treatment right away. if you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Multiple Myeloma, also known as plasma cell myeloma, is related to myeloma and plasmacytoma. An important gene associated with Multiple Myeloma is IRF4 (interferon regulatory factor 4), and among its related pathways is Immune response Oncostatin M signaling via JAK-Stat in human cells. The drugs carmustine and cisplatin and the compounds thalidomide and baff have been mentioned in the context of this disorder. Affiliated tissues include the plasma cells in bone marrow, bone and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A myeloma that is located in the plasma cells in bone marrow.

NIH Rare Diseases:42 Multiple myeloma is a cancer of the plasma cells in the bone marrow. plasma cells help the body fight infection by producing proteins called antibodies. in multiple myeloma, plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. the growth of these bone tumors makes it harder for the bone marrow to make healthy blood cells and platelets. this disease may also harm other tissues and organs, such as the kidneys. multiple myeloma mainly affects older adults. although the exact cause is unknown, there are several known risk factors that can increase a person's chance of getting this disease. last updated: 7/6/2011

Wikipedia:63 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

Description from OMIM:46 254500

Aliases & Classifications for Multiple Myeloma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
multiple myeloma:
Prevalence: 1-5/10000; Age of onset: Adulthood
primary amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

multiple myeloma 8 9 42 46 10 48 33 30 60
plasma cell myeloma 42 44 48
primary systemic amyloidosis 48 60
medullary plasmacytoma 48 60
plasma cell dyscrasia 42 60
primary amyloidosis 48 60
myeloma - multiple 42 22
myelomatosis 42 48
systemic immunoglobulinic amyloidosis 48
immunoglobulin deposition disease 60
immunoglobulinic amyloidosis 48
systemic al amyloidosis 48
light-chain amyloidosis 48
kahler's disease 48
al amyloidosis 48
kahler disease 42


External Ids:

Disease Ontology8 DOID:9538
NCIt39 C3242
OMIM46 254500
MeSH34 D009101
ICD9CM27 203.0
ICD10 via Orphanet26 E85.0, E85.1, E85.2 E85.3, C90.0, E85.8, more
SNOMED-CT via Orphanet57 23132008, 109989006, 55921005
MESH via Orphanet35 D009101, C531616
UMLS via Orphanet61 C0026764, C0268381
ICD1025 C90.0

Related Diseases for Multiple Myeloma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Multiple Myeloma family:

Myeloma Familial Myeloma

Diseases related to Multiple Myeloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma32.5CCND1, TNFRSF17, IRF4, DKK1, MYEOV, IL6R
2plasmacytoma31.3IL6R, IRF4
3amyloidosis31.1APOA1
4chronic lymphocytic leukemia30.7CCND1, TNFRSF13C, TNFRSF17
5hypercalcemia30.6IL6R
6arthritis30.5IL6R
7non-hodgkin lymphoma30.5CCND1, TNFRSF13C, TNFRSF17, IRF4, IL6R
8rheumatoid arthritis30.2TNFRSF13C, TNFRSF17, APOA1, DKK1, IL6R
9multiple sclerosis30.2TNFRSF13C, TNFRSF17, APOA1, IL6R
10plasma cell leukemia30.2CCND1
11lung cancer30.1CCND1
12leukemia10.9
13hodgkin's lymphoma10.7
14extramedullary plasmacytoma10.6
15acute leukemia10.6
16smoldering myeloma10.6
17macroglobulinemia10.6
18neuropathy10.6
19glomerulonephritis10.5
20purpura10.5
21cryoglobulinemia10.4
22cutis laxa10.4
23peripheral neuropathy10.4
24hepatitis10.4
25osteonecrosis10.4
26fanconi syndrome10.4
27myeloid leukemia10.3
28prostatitis10.3
29gaucher's disease10.3
30herpes zoster10.3
31adult syndrome10.3
32poems syndrome10.3
33keratopathy10.3
34kidney disease10.3
35osteosclerosis10.3
36pure red-cell aplasia10.3
37von willebrand's disease10.3
38angiodysplasia10.3
39acute myeloid leukemia10.3
40stevens-johnson syndrome10.3
41thrombotic thrombocytopenic purpura10.3
42bone lymphoma10.3
43monoclonal gammopathy of uncertain significance10.3
44arthropathy10.3
45breast cancer10.3
46prostate cancer10.3
47retinoblastoma10.3
48primary polycythemia10.2
49t-cell large granular lymphocyte leukemia10.2
50graft versus host disease10.2

Graphical network of the top 20 diseases related to Multiple Myeloma:



Diseases related to multiple myeloma

Clinical Features for Multiple Myeloma

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46OMIM
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Clinical features from OMIM:

254500

Clinical synopsis from OMIM:

254500

Drugs & Therapeutics for Multiple Myeloma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Multiple Myeloma

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22GTR
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Genetic tests related to Multiple Myeloma:

id Genetic test Affiliating Genes
1 Multiple Myeloma22

Anatomical Context for Multiple Myeloma

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Multiple Myeloma:

32
Bone, Bone marrow, Kidney, Testes, Endothelial, B cells, T cells, Testis, Lung, Myeloid, Breast, Skin, Nk cells, Liver, Prostate, Monocytes, Pituitary, Heart, Whole blood, Spinal cord, Thyroid, Tongue, Pancreas, Colon, Skeletal muscle, Brain, Lymph node

FMA organs/tissues related to Multiple Myeloma:

14
The plasma cells in bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Myeloma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Multiple Myeloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Multiple Myeloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.0NBEA, PDZK1, TNFRSF13C, APOA1, LIG4, DKK1

Publications for Multiple Myeloma

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50PubMed
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Articles related to Multiple Myeloma:

(show top 50)    (show all 2849)
idTitleAuthorsYear
1
Clinical translation in multiple myeloma: from bench to bedside. (24135399)
2013
2
Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia. (23852547)
2013
3
Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. (24066119)
2013
4
Screening of multiple myeloma by polyclonal rabbit anti-human plasmacytoma cell immunoglobulin. (23560043)
2013
5
Trends in utilization and outcomes of autologous transplantation as early therapy for multiple myeloma. (23939198)
2013
6
Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules. (23178378)
2013
7
Cyclin kinase subunit 1B nuclear expression predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with bortezomib. (22047644)
2012
8
Association of age with fluorescence in situ hybridization abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients. (22574971)
2012
9
Extramedullary multifocal plasmacytoma relapse in multiple myeloma. (21993312)
2012
10
Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. (22591013)
2012
11
IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1. (20974848)
2011
12
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. (20015878)
2010
13
Reactive histiocytosis: a diagnostic dilemma in multiple myeloma. (20699538)
2010
14
Expression of eight genes of nuclear factor-kappa B pathway in multiple myeloma using bone marrow aspirates obtained at diagnosis. (19554506)
2009
15
Analysis of NOTCH1 extracellular juxtamembrane expansion mutations in acute leukemias and multiple myelomas. (19239437)
2009
16
Clinical and immunological evaluation of zoledronate-activated Vgamma9gammadelta T-cell-based immunotherapy for patients with multiple myeloma. (19409955)
2009
17
MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients. (18830254)
2009
18
A role for IFN-lambda1 in multiple myeloma B cell growth. (18830264)
2008
19
Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report. (18291467)
2008
20
Expression of MUM1/IRF4 mRNA as a prognostic marker in patients with multiple myeloma. (17690696)
2008
21
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. (18191696)
2008
22
Mediastinal plasmacytoma with multiple myeloma presenting as a diagnostic dilemma. (18717993)
2008
23
A biased Gm haplotype and Gm paraprotein allotype in multiple myeloma suggests a role for the Gm system in myeloma development. (17373937)
2007
24
Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. (17669398)
2007
25
Inhibition of adenosine monophosphate-activated protein kinase induces apoptosis in multiple myeloma cells. (17351392)
2007
26
Impaired functionality and phenotypic profile of dendritic cells from patients with multiple myeloma. (16542368)
2006
27
Role of the microenvironment in multiple myeloma bone disease. (16787117)
2006
28
Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma. (15531906)
2005
29
Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival. (16247750)
2005
30
Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. (15705788)
2005
31
The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. (15161667)
2004
32
Advances in biology of multiple myeloma: clinical applications. (15090448)
2004
33
Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells. (12576327)
2003
34
Hyperphosphatemia in multiple myeloma. (14667570)
2003
35
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. (12393542)
2003
36
A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model. (12580953)
2003
37
Immunohistochemical identification of HER-2/neu overexpression and CD117 (c-kit) expression in multiple myeloma. (12613538)
2002
38
Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma. (11222401)
2001
39
Serum oncostatin M in multiple myeloma: impact on disease severity and prognosis. (10914939)
2000
40
Clinical-grade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi's sarcoma-associated herpesvirus. (9490666)
1998
41
Peripheral blood monoclonal plasma cells as a predictor of survival in patients with multiple myeloma. (8781435)
1996
42
A CD10-positive subset of malignant cells is identified in multiple myeloma using PCR with patient-specific immunoglobulin gene primers. (7475288)
1995
43
Erythropoiesis and erythropoietin in multiple myeloma. (8528047)
1995
44
Analysis of the B-cell compartment in plasma cell leukemia and multiple myeloma: immunoglobulin gene rearrangement of EBV-infected B-cell lines. (7681918)
1993
45
Interleukin-6 receptor expression and saturation on the bone marrow cells of patients with multiple myeloma. (8426476)
1993
46
Anti-Sa cold agglutinin of IgA class requiring plasma-exchange therapy as early manifestation of multiple myeloma. (8318562)
1993
47
Amyotrophic lateral sclerosis with multiple myeloma]. (2100033)
1990
48
Comment on amyloid neuropathy in light chain multiple myeloma. (2515930)
1989
49
Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma. (4333902)
1972
50
Extramedullary plasmacytoma in multiple myeloma: report of case. (5237184)
1968

Genetic Variations for Multiple Myeloma

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Expression for genes affiliated with Multiple Myeloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Myeloma

Search GEO for disease gene expression data for Multiple Myeloma.

Pathways for genes affiliated with Multiple Myeloma

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53Reactome, 12EMD Millipore
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Pathways related to Multiple Myeloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Oncostatin M signaling via JAK-Stat in human cells
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11.0IL6R, CCND1

Compounds for genes affiliated with Multiple Myeloma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR
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Compounds related to Multiple Myeloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thalidomide44 49 59 1114.1IL6R, DKK1, CCND1
2baff2811.0TNFRSF17, TNFRSF13C
3blys4411.0TNFRSF17, TNFRSF13C
4bcma4410.7TNFRSF17, TNFRSF13C

GO Terms for genes affiliated with Multiple Myeloma

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16Gene Ontology
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Cellular components related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endomembrane systemGO:01250511.2NBEA, LECT1, TNFRSF17

Biological processes related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:01016511.0LIG4, CCND1

Molecular functions related to Multiple Myeloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.5WHSC1, CCND1, PDZK1, IRF4, APOA1, LIG4

Products for genes affiliated with Multiple Myeloma

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  • Antibodies
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  • Antibodies

Sources for Multiple Myeloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet