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MS
MCID: MLT020

Multiple Sclerosis malady
15 drugs, 994 genes, 23 tissues, 1068 related diseases, 28 phenotypes, 2296 articles, clinical trials, genetic tests.

Summaries for Multiple Sclerosis

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6Disease Ontology, 23MedlinePlus, 31NINDS, 15GeneReviews, 33OMIM, 22MalaCards
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MedlinePlus: Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your body attacks itself. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak or walk. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke23

MalaCards: Multiple Sclerosis, also known as multiple sclerosis (disorder), is related to carcinoma and leukemia. An important gene associated with Multiple Sclerosis is MS2 (Multiple sclerosis, susceptibility to, 2), and among its related pathways are p38 Signaling and Tec Kinases Signaling. The drugs cyanocobalmin and methylcobalamin and the compounds calcium and oxygen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.6

NINDS: An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.31

Wikipedia: Multiple sclerosis (MS), also known as \"disseminated sclerosis\" or \"encephalomyelitis disseminata\",...44 more...

OMIM: 126200

GeneReviews summary for ms

Aliases & Descriptions for Multiple Sclerosis

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6Disease Ontology, 15GeneReviews, 16GeneTests, 31NINDS, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt, 19ICD9CM, 24MeSH
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Aliases & Descriptions:

multiple sclerosis 6 15 31 8 33 32 23 43
multiple sclerosis (disorder) 6 16
generalized multiple sclerosis (disorder) 6
multiple sclerosis nos (disorder) 6
light fixation seizure syndrome 43
insular sclerosis 6
mes 16
ms 15

External Ids:

NCIt27 C3243
SNOMED-CT40 24700007, 155023009, 192930001 192928003, more
ICD9CM19 340

Related Diseases for Multiple Sclerosis

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13GeneCards, 14GeneDecks
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Disease types for multiple sclerosis family:

multiple sclerosis 2 multiple sclerosis 3
multiple sclerosis 4

Diseases related to multiple sclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1062)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma122.9PIAS1, LRP1, SH3GL2, RFC1, RFC4, RFC5
2leukemia122.3PIAS1, LRP1, SH2B3, SH3GL2, RFC1, NCAM1
3neuronitis104.2PINK1, LRP1, SH3GL2, KLC1, NCAM1, NCKAP1
4prostatitis100.5PINK1, PIAS1, LRP1, SH2D2A, RFC1, RFC4
5melanoma99.9LRP1, KLC1, RFC5, NCAM1, PDCD1, PDE4A
6lupus erythematosus90.7SH2B3, PDCD1, CNTF, KIR2DS3, KIR2DS5, KIR2DP1
7pancreatitis88.3LRP1, KLC1, NCAM1, PDE4A, RELA, RELN
8alzheimer's disease84.4PINK1, LRP1, KLC1, RFC1, NCAM1, NCKAP1
9adenocarcinoma83.0LRP1, NCAM1, RELA, CNR1, CNTN1, VWF
10thyroiditis82.9LRP1, RFC1, NCAM1, PDE4A, RELA, RELN
11colorectal cancer81.2RFC1, RFC4, NCAM1, CNR1, CNR2, CNTN1
12cerebritis79.6LRP1, NCAM1, PDE4A, RELA, RELN, CNP
13hepatocellular carcinoma79.0RFC4, NCAM1, PDCD1, RELA, RELN, CNR1
14ovarian cancer77.0LRP1, NCAM1, PDCD1, RELA, VWF, VTN
15gastric cancer76.3PIAS1, RFC1, RFC4, RELA, RELN, VWF
16cervicitis73.6RFC1, PDCD1, PDE4A, RELA, CNR1, KIR3DL2
17myeloma73.6LRP1, NCAM1, PDE4A, RELA, CNTF, CNTN2
18lymphocytic leukemia71.9NCAM1, PDE4A, PDE4B, RELA, CNTN2, WASF1
19neuroblastoma70.5LRP1, NCAM1, PDE4A, RELA, RELN, CNR1
20retinitis70.1LRP1, PDE4A, CNR1, CNR2, CNTF, VWF
21atherosclerosis69.7LRP1, PDCD1, PDE4A, CNR1, CNR2, VWF
22diabetes mellitus69.2SH2B3, PDCD1, PDE4A, CNR1, CNR2, KIR2DS5
23fibrosis68.7LRP1, PDE4A, RELA, CNR1, CNR2, VWF
24encephalomyelitis68.1PDE4A, CNP, CNR1, CNTF, CNTNAP1, BTN1A1
25esophagitis67.3NCAM1, PDE4A, RELA, RELN, SGCD, CNR1
26cholesterol66.8PIAS1, LRP1, RELA, RELN, CNP, CNR1
27psoriasis66.6LRP1, RFC1, PDE4A, CNR1, KIR2DS3, KIR2DS5
28malaria65.8PIAS1, LRP1, RFC1, RFC2, RFC4, RFC5
29colon cancer65.5PIAS1, RFC1, NCAM1, PDE4A, RELA, CNR1
30dermatitis65.5PDE4A, RELA, CNR1, KIR3DL2, BTD, SELE
31multiple myeloma65.0LRP1, NCAM1, RELA, CNTF, KIR3DS1, KIR2DS4
32myeloid leukemia63.8NCAM1, PDCD1, RELA, KIR2DS3, KIR2DS5, KIR3DL2
33breast carcinoma63.2LRP1, SH3GL2, CNR2, CNTN2, KIF1B, VWF
34systemic lupus erythematosus63.1PDCD1, VWF, VTN, SELE, VIP, VCAM1
35ischemia62.7NCAM1, PDE4A, RELA, CNR1, CNR2, CNTF
36obesity62.5LRP1, RELA, CNR1, CNR2, CNTF, KIR2DL1
37pneumonia62.0PDE4A, RELA, VTN, BTN1A1, SELE, SELL
38hypoxia62.0LRP1, PDE4A, RELA, VWF, VTN, PCNA
39hypertension61.6LRP1, SH2B3, KLC1, RFC1, NCAM1, PDE4A
40nephropathy60.3LRP1, PDCD1, RELA, VWF, VTN, PCNA
41sarcoma60.1NCAM1, PDE4A, RELA, VWF, VTN, PCNA
42myocardial infarction59.9LRP1, SH2B3, PDCD1, PDE4A, CNR1, CNR2
43influenza59.4RELA, KIR2DL1, KIR2DL2, VTN, PCSK5, SELL
44pulmonary disease59.3PDE4A, PDE4B, VWF, PCNA, GC, NBN
45lymphoblastic leukemia58.8RFC1, NCAM1, RELA, KIR3DL1, VWF, PCNA
46osteoarthritis58.3PDE4A, RELA, CNR1, CNR2, VTN, BTNL2
47gonococcal synovitis58.2LRP1, NCAM1, PDCD1, PDE4A, RELA, CNR1
48pancreatic cancer57.9LRP1, NCAM1, PDE4A, RELA, RELN, VWF
49anemia57.1NCAM1, NCKAP5, PDCD1, RELA, VWF, PCNA
50herpes simplex56.8CNTN2, PCNA, GC, SELPLG, SERPINC1, SERPINE1

Graphical network of the top 20 diseases related to multiple sclerosis:



Graphical network of diseases related to multiple sclerosis

Clinical Features for Multiple Sclerosis

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33OMIM
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Clinical features from OMIM: 126200

Drugs & Therapeutics for Multiple Sclerosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for multiple sclerosis

Drug clinical trials:

Search ClinicalTrials for multiple sclerosis

Search NIH Clinical Center for multiple sclerosis

Search CenterWatch for multiple sclerosis

Inferred drug relations via UMLS/NDF-RT:

43 28 azathioprine, baclofen, carboxymethylcellulose calcium, cladribine, cobalamin concentrate, cyanocobalamin, cyanocobalmin, cyclophosphamide, dantrolene, dantrolene sodium, hydroxocobalamin, hydroxocobalamin acetate, interferon beta-1a, interferon beta-1b, methylcobalamin

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for multiple sclerosis:
Adult bone marrow derived stromal cells for treatment of Multiple Sclerosis
Autologous bone marrow derived CD34+ enriched stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for the treatment of Multiple Sclerosis
Peripheral blood stem cells for the treatment of Multiple Sclerosis
Tcelna™, an autologous T-cell immunotherapy for the treatment of Multiple Sclerosis
Transplantation of placenta-derived mesenchymal stem cells for the treatment of Multiple Sclerosis
Embryonic/Adult Cultured Cells Related to multiple sclerosis:
Human bone marrow-derived mesenchymal stem cells , PMIDs: 22236384, 22277374
Placenta-derived mesenchymal stem cells, PMIDs: 22638856

Genetic Tests for Multiple Sclerosis

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16GeneTests
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Genetic tests related to multiple sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis
clinical/research

Anatomical Context for Multiple Sclerosis

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22MalaCards
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MalaCards organs/tissues related to multiple sclerosis:

22
Brain, Skin, Liver, Spinal cord, Bone marrow, Whole blood, Thymus, Cortex, Cerebellum, Small intestine, Thyroid, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal thyroid, Adrenal cortex, Pituitary

Phenotypes for genes affiliated with Multiple Sclerosis

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25MGI
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MGI Mouse Phenotypes related to multiple sclerosis:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537646.9PINK1, WDR1, LRP1, RFK, RELA, SGCD
2mortality/agingMP:001076843.0PIAS1, WDR1, LRP1, RFK, NCAM1, NCKAP1
3behavior/neurological phenotypeMP:000538636.3PINK1, LRP1, KLC1, NCAM1, RELN, CNP
4growth/size phenotypeMP:000537835.3PINK1, PIAS1, WDR1, LRP1, KLC1, RELA
5nervous system phenotypeMP:000363132.6LRP1, KLC1, NCKAP1, PDCD1, PDE4A, PDE4B
6cardiovascular system phenotypeMP:000538530.6LRP1, NCKAP1, PDCD1, PDE4A, PDE4B, RELA
7normal phenotypeMP:000287327.5LRP1, RELA, VTN, PCK1, GCNT3, SELE
8integument phenotypeMP:001077125.0WDR1, RELA, RELN, CNR1, CNR2, KIF1B
9tumorigenesisMP:000200624.0NBN, SELL, SERPINE1, BRCA1, BRCA2, RAD52
10reproductive system phenotypeMP:000538923.6CNP, CNTNAP1, BTN1A1, NBN, VIP, VIPR2
11muscle phenotypeMP:000536923.2LRP1, PDCD1, RELA, RELN, SGCD, CNP
12vision/eye phenotypeMP:000539121.4NCAM1, PDCD1, RELA, RELN, CNP, CNTN1
13digestive/alimentary phenotypeMP:000538121.0NCKAP1, RELN, CNP, WASF1, VWF, PCSK5
14skeleton phenotypeMP:000539020.4WDR1, LRP1, RELA, CNP, CNR1, KIF1B
15renal/urinary system phenotypeMP:000536718.3PDCD1, PCSK5, GCNT3, BTD, SELP, SELPLG
16respiratory system phenotypeMP:000538818.1CNP, KIF1B, KIF5A, PCSK5, SELL, SELP
17embryogenesis phenotypeMP:000538017.3NCKAP1, NBN, SERPINC1, VIM, BRCA1, BRCA2
18endocrine/exocrine gland phenotypeMP:000537917.2PINK1, CNP, BTN1A1, NBN, SELL, VIPR1
19liver/biliary system phenotypeMP:000537016.7WASF1, PCK1, SERPINC1, BSCL2, VEGFA, BMP4
20adipose tissue phenotypeMP:000537516.1LRP1, CNR1, PCK1, SERPINE1, VIPR2, BSCL2
21craniofacial phenotypeMP:000538215.7PCSK5, NBN, LMNB1, BMP4, BMP5, RAD23B
22hearing/vestibular/ear phenotypeMP:000537715.2WDR1, BSN, VDR, BMP4, BMP5, RARA
23limbs/digits/tail phenotypeMP:000537114.8RELA, PCSK5, BRCA1, BRCA2, VEGFA, VDR
24other phenotypeMP:000539513.3SH2B3, KLC1, SGCD, CNR1, RARA, LEPR
25no phenotypic analysisMP:0003012INFPINK1, CNR1, PCNA, PCSK5, PCK1, BSCL2
26hematopoietic system phenotypeMP:0005397INFWDR1, SH2B3, SH2D2A, PDCD1, CNTF, PCNA
27immune system phenotypeMP:0005387INFPINK1, PIAS1, WDR1, LRP1, SH2D2A, RFK
28cellular phenotypeMP:0005384INFPINK1, WDR1, SH2B3, SH2D2A, KLC1, NCAM1

Publications for genes affiliated with Multiple Sclerosis

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35PubMed
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Articles related to multiple sclerosis:

(show top 50)    (show all 2296)
idTitleAuthorsYearAffiliating Genes
1Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA -CLEC16A-SOCS1 gene complex. (21653641)Zuvich R.L.... Haines J.L.2011SOCS1, CLEC16A
2Inflammatory profile, age of onset, and the MTHFR pol ymorphism in patients with multiple sclerosis. (21190091)Alatab S.... Najmafshar A.2011MTHFR
3Natalizumab treatment in multiple sclerosis: marked d ecline of chemokines and cytokines in cerebrospinal fluid. (20007431)MellergAYrd J.... Dahle C.2010TNF, IFNG, IL10
4Cerebrospinal fluid chitinase 3-like 1 levels are ass ociated with conversion to multiple sclerosis. (20237129)Comabella M.... Montalban X.2010CHI3L1
5Interleukin 10 gene polymorphism in Iranian patients with multiple sclerosis. (20714960)Azarpira N.... Shariat A.2010IL10
6Apoptosis of oligodendrocytes and post-translational modifications of myelin basic protein in multiple sclerosis: possible role for the early stages of multiple sclerosis. (20068323)Artemiadis A.K.... Anagnostouli M.C.2010MBP
7Meta-analysis of genome scans and replication identif y CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (19525953)De Jager P.L.... J.R.2009CXCR4, IL2RA, TNFRSF1A
8Does the DRB1*1501 allele confer more severe and fast er progression in primary progressive multiple sclerosis patients? HLA in prima ry progressive multiple sclerosis. (19616314)Vasconcelos C.C.... Alvarenga R.M.2009HLA-DQB1, HLA-DRB1
9Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. (19465451)Matsushita T.... Kira J.I.2009AQP4
10Long-term adherence to interferon beta therapy in relapsing-remitting multiple sclerosis. (18057899)Portaccio E.... Amato M.P.2008IFNB1
11Therapeutic strategy against multiple sclerosis (19198124)Suzumura A.2008GLS
12The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study. (18408021)Abo-Krysha N.... Rashed L.2008TFRC
13Lack of immune responses against multiple sclerosis-associated retrovirus/human endogenous retrovirus W in patients with multiple sclerosis. (18444086)Ruprecht K.... Mueller-Lantzsch N.2008ERVW-1
14CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population. (18378005)Wray B.N.... McMorran B.J.2008CTLA4, HLA-DRB1
15Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosis. (17273808)Limmroth V.... Wernsdorfer C.2007IFNB1
16Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. (17702782)Tanaka M.... Saida T.2007AQP4
17Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis. (17920697)Stuart R.... Racke M.K.2007CTLA4
18Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. (17715340)Wosik K.... Prat A.2007AGTR1
19Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. (17485236)Chesik D.... Wilczak N.2007IGFBP2
20Multiple sclerosis immunopathic trait and HLA-DR(2)15 as independent risk factors in multiple sclerosis. (17463066)Callander M.... Andersen O.2007HLA-DRB1
21Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis. (17077178)Sun W.... Zhang J.Z.2006VIPR1, VIPR2
22A novel assay to detect low-titred antibodies to interferon beta in multiple sclerosis patients. (16608120)Di Marco P.... Antonelli G.2006IFNA1
23The Italian Multiple Sclerosis Database Network (MSDN): the risk of worsening according to IFNbeta exposure in multiple sclerosis. (17086903)Trojano M.... Livrea P.2006IFNB1
24Decreased FOXP3 levels in multiple sclerosis patients. (15952173)Huan J.... Vandenbark A.A.2005FOXP3
25Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. (16123145)Wiendl H.... Weller M.2005HLA-G
26Interferon beta in relapsing-remitting multiple sclerosis. An eight years experience in a specialist multiple sclerosis centre. (15772741)RA-o J.... Montalban X.2005IFNB1
27CD30 antigen and multiple sclerosis: CD30, an important costimulatory molecule and marker of a regulatory subpopulation of dendritic cells, is involved in the maintenance of the physiological balance between TH1/TH2 immune responses and tolerance. The role of IFNbeta-1a in the treatment of multiple sclerosis. (15990453)Pellegrini P.... Adorno D.2005TNFRSF8
28Apo E in multiple sclerosis and optic neuritis: the apo E-epsilon4 allele is associated with progression of multiple sclerosis. (16193886)Pinholt M.... Christiansen M.2005APOE
29The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. (15105271)Levine S.M.... Chakrabarty A.2004HMOX1
30Interferon beta in multiple sclerosis: experience in a British specialist multiple sclerosis centre. (12810786)Dubois B.D.... Giovannoni G.2003IFNB1
31A controlled trial of natalizumab for relapsing multiple sclerosis. (12510038)Miller D.H.... O'Connor P.W.2003ITGA4
32A C77G point mutation in CD45 exon 4, which is associated with the development of multiple sclerosis and increased susceptibility to HIV-1 infection, is undetectable in Japanese population. (14641523)Sabouri A.H.... Osame M.2003PTPRC
33Expression of CD5 on B lymphocytes correlates with disease activity in patients with multiple sclerosis. (12446024)Seidi O.A.... Sharief M.K.2002CD5
34Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects. (12412939)Pender M.P.... Wolfe N.P.2002IFNG
35Multiple sclerosis: comparison of copolymer-1- reacti ve T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. (10861011)Neuhaus O.... Hohlfeld R.2000IL4, MBP, IFNG
36Transferrin in patients with multiple sclerosis: a comparison among various subgroups of multiple sclerosis patients. (10685854)Zeman D.... Andel M.2000TF
37CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. (10803840)Barcellos L.F.... Oksenberg J.R.2000CCR5
38Immunogenicity of interferon-beta in multiple sclerosis patients: influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group. (11079533)Ross C.... Bendtzen K.2000IFNB1
39A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. (10610182)Madsen L.S.... Fugger L.1999HTLVR
40The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. (10577971)Kollias G.... Kontoyiannis D.1999TNF
41An extensive search for autoantibodies to myelin basic protein in cerebrospinal fluid of non-multiple-sclerosis patients: implications for the pathogenesis of multiple sclerosis. (10473981)Warren K.G.... Catz I.1999MBP
42Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis. (9570575)Ferrante P.... Clerici M.1998IL2, SLAMF1
43Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients. (9686625)Van Weyenbergh J.... Wietzerbin J.1998IFNG, FCGR1A, IFNB1
44Characterization of the mitochondrial genome in childhood multiple sclerosis. II. Multiple sclerosis without optic neuritis and LHON-associated genes. (10029350)Wilichowski E.... Hanefeld F.1998MT-ND4, MT-ND5, MT-ND2
45Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. (9307252)Smith D.R.... Weiner H.L.1997IL4
46A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. (8696344)Haines J.L.... Oksenberg J.R.1996PAH
47New insights into the mechanism of action of copolymer 1 in experimental allergic encephalomyelitis and multiple sclerosis. (8965119)Arnon R.... Teitelbaum D.1996MBP, PLP1, CIITA
48Defective CD3 mediated proliferation and LPS responsiveness in multiple sclerosis. (7520286)Brod S.A.... Scott M.1994MBP, IFNA1
49T cells recognizing multiple peptides of myelin basic protein are found in blood and enriched in cerebrospinal fluid in optic neuritis and multiple sclerosis. (7680141)SAPderstrAPm M.... Olsson T.1993MBP
50Class II major histocompatibility complex antigen expression on unstimulated and gamma-interferon stimulated monocytes from patients with multiple sclerosis, rheumatoid arthritis and normal controls. (1777559)Armstrong M.A.... Bell A.L.1991IFNG

Expression for genes affiliated with Multiple Sclerosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Pathways for genes affiliated with Multiple Sclerosis

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36QIAGEN, 20KEGG, 38Reactome, 3Cell Signaling Technology, 37R&D Systems, 41Thomson Reuters, 10EMD Millipore
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Pathways related to multiple sclerosis according to GeneDecks:

(show top 50)    (show all 174)
idPathwayScoreTop Affiliating Genes
1p38 Signaling3626.6VEGFB, BMP4, BMP5, BMP6, RAC1, LIF
2Tec Kinases Signaling3625.3VEGFB, VAV2, BMP4, BMP5, BMP6, RAC1
3Molecular Mechanisms of Cancer3623.4BRCA1, BMP4, BMP5, BMP6, RARA, LIF
4JAK-STAT Pathway3623.1PIAS1, BRCA1, VEGFB, BMP4, BMP5, BMP6
5PAK Pathway3622.0VEGFB, MYO9B, BMP4, BMP5, BMP6, RAC1
6MAPK Family Pathway3621.5VEGFB, BMP4, BMP5, BMP6, RAC1, BDNF
7ERK Signaling3620.3VEGFB, BMP4, BMP5, BMP6, ZAP70, AXL
8TGF-Beta Pathway3620.3VEGFB, BMP4, BMP5, BMP6, BDNF, BCL2
9PEDF Induced Signaling3620.1RELA, BMP4, BMP5, BMP6, LIF, BDNF
10Transendothelial Migration of Leukocytes3620.0WASF1, VCAM1, VAV2, MYO9B, RAC1, CLDN5
11MIF Mediated Glucocorticoid Regulation3619.1BMP4, BMP5, BMP6, LIF, BCL2, BAX
12Endothelin-1 Signaling Pathway3618.8BMP4, BMP5, BMP6, AXL, MST1R, CD2
13MIF Regulation of Innate Immune Cells3618.8BMP4, BMP5, BMP6, LIF, BCL2, BAX
14PGC1Alpha Pathway3618.2BMP4, BMP5, BMP6, BCL2, BAX, CD2
15Jak-STAT signaling pathway2017.9PIAS1, CNTF, BCL2L1, LEP, LEPR, JAK1
16SOCS Pathway3617.7VEGFB, BMP4, BMP5, BMP6, BCL2, BAX
17IL-6 Pathway3617.6BMP4, BMP5, BMP6, BAX, CD2, CD80
18Chemokine signaling pathway2016.8RELA, VAV2, RAC1, XCL1, JAK2, FOXO3
19Chemokine Signaling3616.7XCL1, JUN, JAK2, ARRB1, IL8, MAPK1
20Cell adhesion molecules (CAMs)2016.7NCAM1, CNTN1, CNTN2, CNTNAP1, SELL, SELP
21Natural killer cell mediated cytotoxicity2016.6KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4
22Hematopoietic cell lineage2016.4CD2, CD24, CD36, CD8A, CD14, CD4
23JNK Pathway3615.8VEGFB, BMP4, BMP5, BMP6, RAC1, BCL2
24Class A/1 (Rhodopsin-like receptors)3815.7CNR1, CNR2, S1PR1, S1PR3, MC1R, CCL4
25Antigen processing and presentation2015.7KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
26Toxoplasmosis2015.5RELA, BIRC2, BIRC3, BCL2, BCL2L1, CIITA
27Toll-like receptor signaling pathway2015.4RELA, RAC1, JUN, CD86, CD14, CD80
28NFAT in Immune Response3615.2VEGFB, BMP4, BMP5, BMP6, BDNF, ZAP70
29Neuroscience315.1PINK1, NCAM1, CNP, BSN, PARK7, SAG
30Allograft rejection2015.0CD28, CD86, CD40LG, CD80, CD40, GZMB
31NF-KappaB Family Pathway3614.9RELA, VEGFB, VAV2, BMP4, BMP5, BMP6
32Osteoclast differentiation2014.7RELA, RAC1, LILRA3, LILRB4, JUN, JAK1
33TNF Superfamily Pathway3614.5JUN, CASP7, CASP10, CASP3, CASP1, CASP2
34NF-KappaB (p50-p65) Pathway3614.5RELA, VEGFB, BMP4, BMP5, BMP6, BDNF
35Graft-versus-host disease2014.4KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
36Leishmaniasis2014.3RELA, JUN, JAK1, JAK2, ITGA4, ITGB1
37Chagas disease (American trypanosomiasis)2014.3RELA, SERPINE1, CFLAR, JUN, IL10, IL12A
38Cellular Apoptosis Pathway3614.1VEGFB, BMP4, BMP5, BMP6, BIRC2, BDNF
39Cytokine Network3614.0IL10, IL12A, IL12B, IL13, IL15, IL16
40Staphylococcus aureus infection2014.0SELP, SELPLG, CFD, ITGAL, FCAR, FCGR1A
41Th1 Differentiation3713.9JUN, JAK1, JAK2, CD28, CD86, CD4
42TRAF Pathway3613.8BIRC2, BIRC3, UBD, JUN, IL12A, IL12B
43Apoptotic Pathways in Synovial Fibroblasts3613.6VEGFB, BMP4, BMP5, BMP6, BDNF, CFLAR
44Nucleotide excision repair2013.3RFC1, RFC2, RFC4, RFC5, PCNA, RAD23A
45Cytokine production by Th17 cells in CF (Mouse model)4112.8RELA, JAK2, CD14, FOXP3, IRF4, IL12B
46Apoptosis and survival Apoptotic TNF-family pathways1012.8BIRC2, BCL2, BCL2L1, BAX, XIAP, CD27
47Apoptosis and survival_Apoptotic TNF-family pathways4112.8BIRC2, BCL2, BCL2L1, BAX, XIAP, CD27
48IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types3712.8GZMB, IL12B, IL17A, IL17F, IL1B, IL21
49Selected targets of GCR-alpha1012.6VIPR1, LEP, CHAT, ATP1A1, INS, IL1B
50Nucleotide Excision Repair Pathway3612.4RFC1, RFC2, RFC4, RFC5, PCNA, RAD23B

Compounds for genes affiliated with Multiple Sclerosis

about this section
Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to multiple sclerosis according to GeneDecks:

(show top 50)    (show all 470)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 47.5LRP1, PDE4A, RELA, RELN, CNR1, CNTF
2oxygen32 18 29.8CNTN2, SELPLG, BRCA1, VEGFB, RAC1, LIF
3atp32 27.0PINK1, RFC1, RFC2, RFC4, RFK, NCAM1
4cysteine32 26.3LRP1, CNTN2, KIR2DS4, VTN, PCNA, BTD
5creatinine32 24.7NCAM1, VWF, PCNA, GC, SELE, SELL
6histamine32 18 25.7NCAM1, PDE4A, CNR1, CNTF, VWF, PCNA
7adenylate32 24.4PDE4A, CNP, CNR1, CNR2, CNTF, VWF
8actinomycin d32 22.1PDE4A, CNTF, SELE, SERPINE1, VIM, VIPR1
9lactate32 21.5NCAM1, VWF, VTN, PCNA, BTD, SELE
10nmda32 42 21.8LRP1, NCAM1, PDE4A, RELN, CNR1, VIM
11leucine32 18.7LRP1, CNTN2, KIR3DL1, VIM, RAC1, LILRB4
12ethanol32 34 9 18 9 22.0NCAM1, BLVRB, BDNF, BCHE, LEPR, CHAT
13matrigel32 17.7LRP1, NCAM1, VWF, VTN, SELE, SERPINE1
14ccl332 17.1XCL1, MMP9, IL10, IL11, IL13, IL15
15choline32 9 18 9 18.7CNTF, CNTN2, VIM, VIP, LIF, BLVRB
16cocaine32 9 9 17.6PDE4A, CNR1, CNTF, SELE, SELP, VIM
175fluorouracil32 15.4PCNA, SELE, BRCA1, VEGFA, VDR, LIF
18nacl32 15.3RAD51, LIG4, LIF, BDNF, XRCC5, P2RX7
19calcitriol32 42 9 18 9 19.1GC, VDR, BMP6, RARA, LIF, BAK1
20morphine32 9 9 17.0CNR1, VIP, SAG, MME, MIF, ARRB1
21tetracycline32 9 9 16.6CNTN2, VWF, RAC1, S100A8, FURIN, CD40LG
22glycogen32 18 15.5LRP1, RELN, PCK1, BTD, VIM, LIF
23cytochalasin d32 42 15.5VWF, VTN, SELE, SELL, VIM, VCAM1
24latex32 14.5CNTN2, VWF, VTN, SELPLG, LIF, SAA4
25heparan sulfate32 18 15.4LRP1, NCAM1, VTN, GC, SERPINC1, SERPINE1
26lysine32 14.4PIAS1, RELA, CNTN2, KIR3DL1, BTD, BRCA1
27phenylalanine32 14.0BTD, SELPLG, BDNF, CIITA, ZAP70, FURIN
28troglitazone32 42 9 9 16.9SELE, SERPINE1, VDR, VCAM1, BMP6, RARA
29alpha tocopherol32 13.7VCAM1, LIF, LEP, MTHFR, XRCC1, SAA4
30ibmx32 13.6PDE4A, VIP, VCAM1, BDNF, CIITA, CFD
31mitomycin c32 13.5VWF, PCNA, NBN, BRCA1, BRCA2, VCAM1
32histidine32 13.2PDE4A, RAD51, RARA, PAM, CIITA, XRCC1
33imiquimod32 42 9 9 16.2BMP6, MX1, IL10, IL12B, IL18, IL1A
34glycerol32 9 18 9 16.2PDE4A, VWF, PCNA, PCK1, SERPINC1, BRCA1
35peroxynitrite32 13.1PARP1, XDH, MPO, GSR, APOH, CCL11
36homocysteine32 18 14.0VWF, SELE, SELP, SERPINC1, SERPINE1, VCAM1
373-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32 12.9PCNA, PARP1, BCL2, BCL2L1, BAK1, BAX
38fluvastatin32 34 9 9 15.6VWF, SELP, SERPINE1, VCAM1, RAC1, CD40
39gold32 12.5BRCA1, BRCA2, RAD51, MUC1, S100A8, MMP3
40adriamycin32 12.4VIM, BRCA1, BRCA2, VDR, BIRC2, BIRC3
41triptolide32 12.3VEGFA, BIRC3, PARP1, BCL2, BAX, JUN
42marimastat32 42 9 9 15.3VEGFA, MMP1, MMP10, MMP12, MMP14, MMP17
43amphotericin b32 12.1IL13, IL1R1, IL1RAPL2, IL1RN, IL4, IL5
44vincristine32 34 9 9 15.0NCAM1, ITGA4, FGF2, MAP2, IFNA1, IFNB1
45clozapine32 34 9 9 15.0LEP, CHRM2, CHRM3, MPO, IL10, IL18R1
46nicotine32 34 9 9 14.8SELL, CCR7, GPT, CACNA1B, TMPO, PTPN6
47pioglitazone32 9 9 13.6BSG, VEGFA, VCAM1, RARA, LEP, CFD
48bortezomib32 9 9 13.2BRCA1, VEGFA, VCP, PARP1, BCL2, BCL2L1
49aprotinin32 9 9 12.9LRP1, VWF, SELP, SERPINC1, VIP, FURIN
50geldanamycin32 9 9 12.1VEGFA, PARP1, PARK2, BCL2L1, CFLAR, JUN

GO Terms for genes affiliated with Multiple Sclerosis

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Sources:
12Gene Ontology
See all sources

Cellular components related to multiple sclerosis according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588643.4SH3GL2, NCAM1, PDCD1, SGCD, CNP, CNR1
2cytoplasmGO:00573731.5LRP1, SH2D2A, SH3GL2, RFK, RELA, RELN
3integral to plasma membraneGO:00588729.8LRP1, CNR1, CNR2, CNTN2, CNTNAP1, KIR2DS3
4extracellular spaceGO:00561529.1RELN, CNP, CNTF, VTN, PCSK5, GC
5cytosolGO:00582926.1PINK1, WDR1, SH2B3, SH3GL2, KLC1, RFK
6external side of plasma membraneGO:00989718.5NCAM1, VWF, SELL, SELP, VCAM1, LAG3
7nucleoplasmGO:00565417.5ZNF45, PIAS1, RFC1, RFC2, RFC4, RFC5
8cell surfaceGO:00998616.6NCAM1, CNTN2, VEGFA, VCAM1, RARA, SCN5A
9perinuclear region of cytoplasmGO:04847114.8PDE4A, PDE4B, CNP, KIF5A, GC, SELE
10membrane raftGO:04512113.7SELE, BSG, P2RX7, ATP2B2, FURIN, JAK2
11neuronal cell bodyGO:04302513.5CNTF, CNTN2, PAFAH1B1, KCNB2, CHRM2, CHAT
12proteinaceous extracellular matrixGO:00557813.1RELN, VWF, VEGFA, BMP4, CHI3L1, KAL1
13extracellular regionGO:005576INFWDR1, NCAM1, VWF, VTN, GC, BTN1A1

Biological processes related to multiple sclerosis according to GeneDecks:

(show top 50)    (show all 75)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695526.9CNR2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1
2signal transductionGO:00716523.1SH2D2A, SH3GL2, PDCD1, PDE4A, PDE4B, CNTF
3inflammatory responseGO:00695422.3RELA, CNR2, SELE, SELP, BMP6, RAC1
4cytokine-mediated signaling pathwayGO:01922119.3PIAS1, NCAM1, RELA, VCAM1, CIITA, MX1
5apoptotic processGO:00691518.0NCKAP1, PDCD1, KIF1B, NBN, VIM, BRCA1
6positive regulation of transcription from RNA polymerase II promoterGO:04594417.9RELA, SERPINE1, BRCA1, VEGFA, VDR, BMP4
7innate immune responseGO:04508717.6RELA, CLEC4C, BCL2, BCL2L1, MX1, S100B
8cell adhesionGO:00715517.2NCAM1, RELN, CNTN1, CNTN2, CNTNAP1, VWF
9cell-cell signalingGO:00726717.0PCSK5, VIPR2, XCL1, CD86, CD80, CD97
10cell surface receptor signaling pathwayGO:00716616.9BSG, BIRC2, BIRC3, LEPR, LAG3, SAG
11response to virusGO:00961516.5CHRM2, MX1, XCL1, MST1R, FOXP3, ISG20
12DNA repairGO:00628116.3RFC1, RFC2, RFC4, RFC5, PCNA, NBN
13regulation of immune responseGO:05077616.0KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2
14virus-host interactionGO:01904816.0RELA, VIM, VCAM1, RAD23A, BICD1, YWHAE
15interferon-gamma-mediated signaling pathwayGO:06033315.9PIAS1, NCAM1, VCAM1, CIITA, B2M, JAK1
16response to drugGO:04249315.8PDE4A, NBN, RAD54L, PARK7, PAM, BDNF
17anti-apoptosisGO:00691615.7RELA, NAIP, VEGFB, BIRC2, BIRC3, BDNF
18proteolysisGO:00650815.7RELN, PCSK5, PARK7, UBD, CFD, CFLAR
19chemotaxisGO:00693515.5S100A8, L1CAM, KAL1, FGF2, IL4, MAPK1
20positive regulation of cell proliferationGO:00828415.4CNTF, NBN, VIP, VIPR1, VEGFA, RARA
21response to lipopolysaccharideGO:03249614.9CNR1, CNR2, SELE, SELP, BDKRB1, S100A8
22cell proliferationGO:00828314.8SH2D2A, PCNA, NBN, LIG4, BCL2L1, CHRM3
23type I interferon-mediated signaling pathwayGO:06033714.7MX1, JAK1, ISG20, IRF1, IRF2, IRF3
24T cell costimulationGO:03129514.4PDCD1, RAC1, CD28, CD24, CD86, CD4
25response to hypoxiaGO:00166614.4VEGFA, VCAM1, PAM, BCL2, LEP, CHAT
26agingGO:00756814.3CNR1, VDR, VCAM1, BAK1, FURIN, JUN
27positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312314.1PINK1, RELA, BIRC2, BIRC3, PARK2, UBD
28positive regulation of T cell proliferationGO:04210213.9VCAM1, CD276, CD28, CD1D, ITGAL, IL12A
29induction of apoptosisGO:00691713.9MX1, BAX, CD2, CD27, ITM2B, IRF1
30nucleotide-excision repairGO:00628913.6RFC1, RFC2, RFC4, RFC5, PCNA, BRCA2
31positive regulation of interferon-gamma productionGO:03272913.6CD40LG, IRF8, IL12A, IL12B, IL12RB1, IL12RB2
32cellular response to lipopolysaccharideGO:07122213.4SERPINE1, CMPK2, AXL, CD36, CD14, IRF8
33blood coagulationGO:00759613.4WDR1, SH2B3, KLC1, KIF5A, VWF, SELL
34leukocyte migrationGO:05090013.1SELL, SELP, SELPLG, BSG, L1CAM, CD58
35negative regulation of apoptotic processGO:04306613.1RELA, SERPINE1, VEGFA, BMP4, BMP5, BIRC2
36transcription-coupled nucleotide-excision repairGO:00628313.0RFC1, RFC2, RFC4, RFC5, PCNA, XAB2
37positive regulation of inflammatory responseGO:05072913.0SERPINE1, JAK2, CD47, IL12B, IL15, IL18
38response to ethanolGO:04547112.9CNR1, BCL2, CHAT, BAK1, S100A8, CD27
39positive regulation of interleukin-12 productionGO:03273512.9CD36, CD40LG, CD40, IRF8, IL12B, IL23A
40nucleotide-excision repair, DNA damage removalGO:00071812.8RAD23B, XPA, XPC, CDK7, MNAT1, GTF2H1
41positive regulation of apoptotic processGO:04306512.7CNR1, BMP4, UBD, BAK1, BAX, P2RX7
42negative regulation of neuron apoptotic processGO:04352412.6CNTF, NAIP, VEGFB, LIG4, PARK7, PARK2
43base-excision repairGO:00628412.0PCNA, LIG3, PARP1, PARP2, MUTYH, XRCC1
44response to estradiol stimulusGO:03235511.9GC, BRCA2, VDR, BMP4, RARA, PAM
45response to oxidative stressGO:00697911.9BTG1, XPA, MPO, MMP9, MICB, MBL2
46platelet activationGO:03016811.7WDR1, VWF, SELP, SERPINE1, VEGFA, VEGFB
47telomere maintenanceGO:00072311.7RFC1, RFC2, RFC4, RFC5, PCNA, NBN
48response to gamma radiationGO:01033211.6BRCA2, LIG4, BCL2, BAK1, BAX, XRCC2
49positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.5RELN, VTN, VEGFA, VEGFB, LIF, JAK2
50double-strand break repairGO:00630210.8NBN, BRCA1, BRCA2, VCP, RAD51, RAD52

Molecular functions related to multiple sclerosis according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551548.5RTN4R, CXCR4, CX3CR1, CX3CL1, OGG1, OPA1
2cytokine activityGO:00512518.1IL2, IL10, GRN, GREM2, FGF2, MIF
3protein homodimerization activityGO:04280317.7DST, NTRK2, SRF, OLIG2, DARS2, PTGS2
4receptor bindingGO:00510217.4GDNF, GAS6, ADIPOQ, ADCYAP1, CD276, JAK2
5receptor activityGO:00487214.8TNFRSF6B, TNFRSF17, TNFRSF13B, TNFRSF11B, F2RL1, ICAM1
6growth factor activityGO:00808314.5CSF3, NTF3, GH1, F2, IL9, IL7
7chemokine activityGO:00800914.2CXCL9, CXCL13, CXCL12, CCL20, CCL11, CCL2
8transmembrane signaling receptor activityGO:00488813.6KLRB1, NGFR, CR2, TNFRSF8, ERBB3, GIPR
9metalloendopeptidase activityGO:00422213.4SPG7, MMP9, MMP8, MMP7, MMP3, PITRM1
10damaged DNA bindingGO:00368412.5NEIL2, MPG, XPC, XPA, XRCC1, RAD23B
11DNA-dependent ATPase activityGO:00809411.7ERCC8, ERCC3, ERCC2, CCNH, GTF2H4, GTF2H1
12enzyme bindingGO:01989911.6NOTCH1, NOD2, PPARG, PTGS2, TP53, HMOX1
13protease bindingGO:00202011.3HSPA1B, TP53, TNF, TNFAIP3, TNFRSF1A, DPP4

Sources for Multiple Sclerosis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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