MS
MCID: MLT020
MIFTS: 82

Multiple Sclerosis (MS) malady

Neuronal diseases category

Summaries for Multiple Sclerosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and encephalomyelitis. An important gene associated with Multiple Sclerosis is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are Influenza A and Leishmaniasis. The drugs cyclophosphamide and hydroxocobalamin and the compounds lipid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are immune system and reproductive system.

Disease Ontology:8 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

NIH Rare Diseases:42 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:43 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Genetics Home Reference:21 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

Wikipedia:63 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Description from OMIM:46 612594,612596,126200,612595,614810

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

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Sources:
8Disease Ontology, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 46OMIM, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

multiple sclerosis 8 19 42 20 21 43 10 44 33 30 60
ms 19 42 21
generalized multiple sclerosis 8
multiple sclerosis nos 8
disseminated sclerosis 21
insular sclerosis 8


External Ids:

Disease Ontology8 DOID:2377
NCIt39 C3243
ICD9CM27 340
MeSH34 D009103
ICD1025 G35

Related Diseases for Multiple Sclerosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Multiple Sclerosis family:

Primary Progressive Multiple Sclerosis Multiple Sclerosis 4
Multiple Sclerosis 3 Multiple Sclerosis 1
Multiple Sclerosis 2 Multiple Sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis31.9MBP, IFNB1, MOG
2encephalomyelitis31.4MOG, IFNB1, MBP, CIITA, IL17A, C5AR1
3optic neuritis31.3MBP, IFNB1, MOG
4neuritis31.3MBP, CIITA
5neuromyelitis optica31.2MOG, IFNB1, MBP
6primary progressive multiple sclerosis31.0MBP, IFNB1, MOG
7secondary progressive multiple sclerosis31.0MBP, IFNB1
8acute disseminated encephalomyelitis30.9MOG, MBP
9myelitis30.8MBP
10encephalitis30.6MOG, MBP, CIITA, IL12B, IL17A, C5AR1
11lupus erythematosus30.6C3
12systemic lupus erythematosus30.6IFNB1, CIITA, IL12B, IL17A, C5AR1, C3
13arthritis30.6GABBR1, CIITA, IL17A, C5AR1, C3
14alzheimer's disease30.5C5AR1
15rheumatoid arthritis30.5MOG, IFNB1, CIITA, IL12B, IL17A, C5AR1
16measles30.5IL12B, CIITA, MBP, IFNB1
17central nervous system disease30.5IL17A, MBP, MOG
18tropical spastic paraparesis30.5IFNB1, MBP
19myasthenia gravis30.4MBP, MOG
20subacute sclerosing panencephalitis30.4MBP, MOG
21vasculitis30.4C3, IL17A
22hepatitis30.2IFNB1
23sarcoidosis30.2IL12B
24chronic inflammatory demyelinating polyradiculoneuropathy30.2IFNB1
25diabetes mellitus30.2C3
26herpes simplex30.2PVRL2, IFNB1, IL12B
27celiac disease30.2TAGAP, CIITA
28tetanus30.0MOG, MBP, GABBR1, CIITA
29lyme disease30.0CIITA, MBP
30hepatitis b29.9CIITA, MBP, MOG
31tuberculosis29.8IFNB1, MBP, CIITA, IL12B, IL17A, C5AR1
32ischemia29.8GABBR1, CIITA, IL17A, C5AR1
33guillain-barre syndrome29.8MBP, MOG
34dermatitis29.8IL17A
35hepatitis c29.8IFNB1, MBP, CIITA, IL12B
36asthma29.7IFNB1, MBP, CIITA, IL12B, IL17A, C5AR1
37venous insufficiency10.8
38cerebritis10.7
39progressive relapsing multiple sclerosis10.7
40retinitis10.6
41neuronitis10.6
42neurologic diseases10.6
43progressive multifocal leukoencephalopathy10.5
44trigeminal neuralgia10.5
45infectious mononucleosis10.5
46brain disease10.4
47cervicitis10.4
48uveitis10.4
49leukemia10.4
50restless legs syndrome10.4

Graphical network of the top 20 diseases related to Multiple Sclerosis:



Diseases related to multiple sclerosis

Clinical Features for Multiple Sclerosis

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

612594,612596,126200,612595,614810

Drugs & Therapeutics for Multiple Sclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple Sclerosis

Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Search CenterWatch for Multiple Sclerosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19478280
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

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Sources:
20GeneTests
See all sources

Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis20

Anatomical Context for Multiple Sclerosis

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Multiple Sclerosis:

32
T cells, Brain, Spinal cord, Bone, Testes, Monocytes, B cells, Endothelial, Thyroid, Bone marrow, Nk cells, Pituitary, Liver, Myeloid, Cortex, Skin, Eye, Cerebellum, Heart, Thymus, Pineal, Lung, Whole blood, Thalamus, Fetal brain, Hypothalamus, Ovary, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Multiple Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1C3, MOG, IFNB1, MBP, CIITA, IL12B
2MP:000538911.8MBP, GABBR1, TALDO1, TAGAP, C5AR1, C3
3MP:000539711.7MOG, IFNB1, MBP, CIITA, IL12B, IL17A

Publications for Multiple Sclerosis

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Sources:
50PubMed
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Articles related to Multiple Sclerosis:

(show top 50)    (show all 4771)
idTitleAuthorsYear
1
Group exercise training for balance, functional status, spasticity, fatigue and quality of life in multiple sclerosis: a randomized controlled trial. (23543341)
2013
2
Prevalence and significant determinants of post-traumatic stress disorder in a large sample of patients with multiple sclerosis. (23053829)
2013
3
Vitamin D immunomodulatory potential in multiple sclerosis. (24191393)
2013
4
Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. (23612879)
2013
5
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. (24278027)
2013
6
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. (24234648)
2013
7
Serum levels of IL-17A in patients with relapsing-remitting multiple sclerosis treated with interferon-I^. (23207971)
2013
8
Spasticity improvement in patients with relapsing-remitting multiple sclerosis switching from interferon-I^ to glatiramer acetate: the Escala Study. (22133480)
2012
9
Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature. (21537556)
2011
10
Oligoclonal bands predict multiple sclerosis after optic neuritis: a literature survey. (21159718)
2011
11
Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-I+ polymorphisms with risk and clinical course of multiple sclerosis in a Polish population. (21621860)
2011
12
Magnetic resonance imaging at first episode in pediatric multiple sclerosis retrospective evaluation according to KIDMUS and lesion dissemination in space criteria. (19682809)
2010
13
Routine interferon-neutralising antibody testing in patients with relapsing-remitting multiple sclerosis. (21125049)
2010
14
Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction. (20225292)
2010
15
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. (19557869)
2009
16
Cognitive-linguistic deficit and speech intelligibility in chronic progressive multiple sclerosis. (19294553)
2009
17
Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis. (19664140)
2009
18
Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations. (19009343)
2009
19
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. (18354419)
2008
20
Relationship between MRI lesion activity and response to IFN-beta in relapsing-remitting multiple sclerosis patients. (18562504)
2008
21
Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients. (18926575)
2008
22
Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis. (18474739)
2008
23
Cytokine responses to acute and chronic exercise in multiple sclerosis. (18388249)
2008
24
Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis. (18776589)
2008
25
Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. (18588574)
2008
26
Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. (18276777)
2008
27
Parent of origin in multiple sclerosis: understanding inheritance in complex neurologic diseases. (18779508)
2008
28
Intercellular adhesion molecule-1 gene polymorphism in Iranian patients with multiple sclerosis. (17868277)
2007
29
Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis. (16806498)
2006
30
Charles Bonnet syndrome associated with a first attack of multiple sclerosis. (16365804)
2005
31
Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. (16210596)
2005
32
Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. (15147461)
2004
33
C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis. (14644039)
2003
34
Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. (12926836)
2003
35
Multiple sclerosis, interferon beta and clinical thyroid dysfunction. (12580868)
2003
36
Anti-viral properties of interferon beta treatment in patients with multiple sclerosis. (12120696)
2002
37
Treatment of multiple sclerosis with the pregnancy hormone estriol. (12325070)
2002
38
Monocytes in multiple sclerosis: phenotype and cytokine profile. (11108949)
2001
39
IL-18 in patients with multiple sclerosis. (11551238)
2001
40
Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis. (11696222)
2001
41
Metalloproteinases and their tissue inhibitors in multiple sclerosis. (10330301)
1999
42
Cytokine analysis in multiple sclerosis by competitive RT - PCR: A decreased expression of IL-10 and an increased expression of TNF-alpha in chronic progression. (10516778)
1999
43
Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. (9542955)
1998
44
Pathogenesis and therapy of multiple sclerosis. The role of cytokines]. (7715757)
1995
45
Human myelin basic protein (MBP) epitopes recognized by mouse MBP-selected T cell lines from multiple sclerosis patients. (7507496)
1994
46
Multiple sclerosis: occurrence of myelin basic protein peptide-reactive T cells in healthy family members. (7518178)
1994
47
Role of predisposing and protective HLA-DQA and HLA-DQB alleles in Sardinian multiple sclerosis. (8442703)
1993
48
Heterogeneity of the T-cell receptor beta gene rearrangements generated in myelin basic protein-specific T-cell clones isolated from a patient with multiple sclerosis. (1710434)
1991
49
Mood disorder and multiple sclerosis. (3827692)
1987
50
Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. (6607973)
1983

Genetic Variations for Multiple Sclerosis

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Expression for genes affiliated with Multiple Sclerosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Search GEO for disease gene expression data for Multiple Sclerosis.

Pathways for genes affiliated with Multiple Sclerosis

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Sources:
29KEGG
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Pathways related to Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4C3, IL12B, CIITA, IFNB1, PVRL2
2
Hide members
11.2CIITA, IL12B, IL17A, C3
311.2C3, IL12B, CIITA, IFNB1

Compounds for genes affiliated with Multiple Sclerosis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1lipid4412.4MOG, IFNB1, MBP, CIITA, IL12B, IL17A
2tyrosine4412.3PVRL2, IFNB1, MBP, GABBR1, CIITA, CD6
3rantes4411.8IFNB1, CIITA, IL12B, IL17A, C5AR1
4pge24411.8C5AR1, IL17A, IL12B, CIITA, IFNB1
5cysteine4411.8IFNB1, MBP, GABBR1, CIITA, C5AR1, C3
6glucose4411.7MOG, IFNB1, GABBR1, CIITA, TALDO1, C3
7creatinine4411.7IFNB1, MBP, IL17A, C5AR1, C3
8glatiramer acetate44 1112.6CIITA, MBP, IFNB1, MOG
9sb 20358044 5912.4IFNB1, IL12B, IL17A, C5AR1
10polyinosinic-polycytidylic acid4411.4IFNB1, CIITA, IL12B
11peptidoglycan44 2812.4IL12B, CIITA, IFNB1
12ccl444 2812.3IFNB1, IL12B, IL17A
13silver4411.2MBP, IFNB1, MOG
14compstatin control peptide5911.2C5AR1, C3
15ndt 95137275911.2C5AR1, C3
16compstatin5911.2C5AR1, C3
17edss4411.2IFNB1, MBP
18c3bot (154-182)5911.2MOG, MBP
19ono 25065911.2MOG, MBP
20nogo-66 (1-40)5911.2MOG, MBP
21mog (35-55)5911.1MOG, MBP
22plp (139-151)5911.1MOG, MBP
23endotoxin4411.1CIITA
24sodium dodecylsulfate4411.0IL12B, CIITA, MBP
25pd 98,0594410.9IFNB1, IL12B, IL17A, C5AR1
26mezerein4410.9MBP, IFNB1
27cycloheximide4410.9IFNB1
282,3-cyclic nucleotide4410.9MOG, MBP
29pmsf4410.9C5AR1, MBP

GO Terms for genes affiliated with Multiple Sclerosis

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Sources:
16Gene Ontology
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Biological processes related to Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.4C3, C5AR1, IL17A, CIITA, MBP
2positive regulation of osteoclast differentiationGO:04567210.9IL17A, IL12B
3positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.8PVRL2, IL12B
4natural killer cell activationGO:03010110.6IL12B, IFNB1

Products for genes affiliated with Multiple Sclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet