MS
MCID: MLT020
MIFTS: 69

Multiple Sclerosis (MS) malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Multiple Sclerosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 20GeneReviews, 34MalaCards
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MedlinePlus:35 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and encephalomyelitis. An important gene associated with Multiple Sclerosis is IL17A (interleukin 17A). The drugs cyclophosphamide and hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Disease Ontology:9 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

NIH Rare Diseases:44 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerveā€™s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:45 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Wikipedia:66 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Description from OMIM:48 126200,612595,612594,614810,612596

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

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Sources:
9Disease Ontology, 20GeneReviews, 44NIH Rare Diseases, 21GeneTests, 22Genetics Home Reference, 45NINDS, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 48OMIM, 41NCIt, 36MeSH, 28ICD9CM, 59SNOMED-CT, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

multiple sclerosis 9 20 44 21 22 45 11 46 35 32 63
ms 20 44 22
generalized multiple sclerosis 9
disseminated sclerosis 22
multiple sclerosis nos 9
insular sclerosis 9


External Ids:

Disease Ontology9 DOID:2377
NCIt41 C3243
MeSH36 D009103
ICD9CM28 340
ICD1026 G35

Related Diseases for Multiple Sclerosis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Multiple Sclerosis family:

Primary Progressive Multiple Sclerosis Multiple Sclerosis 4
Multiple Sclerosis 3 Multiple Sclerosis 1
Multiple Sclerosis 2 Multiple Sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 558)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis11.3
2encephalomyelitis11.0
3neuritis10.9
4optic neuritis10.9
5pediatric multiple sclerosis10.9
6neuromyelitis optica10.9
7venous insufficiency10.9
8spasticity10.8
9cerebritis10.8
10blindness10.7
11allergic encephalomyelitis10.7
12acute disseminated encephalomyelitis10.7
13secondary progressive multiple sclerosis10.7
14primary progressive multiple sclerosis10.7
15retinitis10.6
16neuronitis10.6
17neurologic diseases10.6
18progressive multifocal leukoencephalopathy10.6
19cerebral atrophy10.6
20endotheliitis10.6
21myelitis10.5
22trigeminal neuralgia10.5
23infectious mononucleosis10.5
24autonomic dysfunction10.5
25cervicitis10.5
26uveitis10.5
27leukemia10.5
28transverse myelitis10.5
29memory impairment10.5
30encephalitis10.4
31lupus erythematosus10.4
32tremor10.4
33restless legs syndrome10.4
34systemic lupus erythematosus10.4
35spastic paraparesis10.4
36neurogenic bladder10.4
37arthritis10.4
38thyroiditis10.4
39hematopoietic stem cell transplantation10.4
40neuropathy10.4
41ophthalmoplegia10.4
4221-hydroxylase deficiency10.4
43lateral sclerosis10.4
44tropical spastic paraparesis10.4
45familial mediterranean fever10.4
46alzheimer's disease10.4
47measles10.4
48parkinson's disease10.4
49amyotrophic lateral sclerosis10.4
50meningitis10.4

Graphical network of the top 20 diseases related to Multiple Sclerosis:



Diseases related to multiple sclerosis

Symptoms for Multiple Sclerosis

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Sources:
48OMIM
See all sources


Clinical features from OMIM:

126200,612595,612594,614810,612596

Drugs & Therapeutics for Multiple Sclerosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple Sclerosis

Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Search CenterWatch for Multiple Sclerosis

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19478280
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

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Sources:
21GeneTests
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Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis21

Anatomical Context for Multiple Sclerosis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Multiple Sclerosis:

34
T cells, Brain, Spinal cord, Bone, Testes, Monocytes, B cells, Endothelial, Thyroid, Bone marrow, Myeloid, Pituitary, Nk cells, Cortex, Skin, Liver, Eye, Pineal, Heart, Cerebellum, Thymus, Whole blood, Fetal brain, Thalamus, Hypothalamus, Pons, Lung, Ovary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

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Publications for Multiple Sclerosis

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Sources:
53PubMed
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Articles related to Multiple Sclerosis:

(show top 50)    (show all 4687)
idTitleAuthorsYear
1
Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis. (24312102)
2013
2
IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. (23726764)
2013
3
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency in people with multiple sclerosis: a summary of a Cochrane systematic review. (23781006)
2013
4
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
2013
5
Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations. (23602715)
2013
6
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
2013
7
Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing-remitting multiple sclerosis patients. (23425504)
2013
8
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. (23472185)
2013
9
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. (23910387)
2013
10
Methodological issues with the risk of relapse study in patients with multiple sclerosis after yellow fever vaccination. (22232361)
2012
11
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
12
Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients. (22608171)
2012
13
Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains. (21737148)
2011
14
Influence of histocompatibility genes on disease susceptibility and treatment response in patients with relapsing-remitting multiple sclerosis treated with interferon I^-1a. (21785677)
2011
15
Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis. (20051521)
2010
16
Cerebellar information processing in relapsing-remitting multiple sclerosis (RRMS). (20714060)
2010
17
Magnetic resonance imaging at first episode in pediatric multiple sclerosis retrospective evaluation according to KIDMUS and lesion dissemination in space criteria. (19682809)
2010
18
Chronic cerebrospinal venous insufficiency and multiple sclerosis. (20373339)
2010
19
Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. (20309394)
2010
20
Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: is it a susceptibility gene? (20483145)
2010
21
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. (19631393)
2009
22
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis. (19039022)
2009
23
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (19525953)
2009
24
Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. (19251277)
2009
25
HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). (19585166)
2009
26
In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. (17911184)
2008
27
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
28
Cytokine changes during interferon-beta therapy in multiple sclerosis: correlations with interferon dose and MRI response. (17328965)
2007
29
Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosis. (17273808)
2007
30
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
31
Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis. (16899302)
2006
32
Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. (16400315)
2005
33
Charles Bonnet syndrome associated with a first attack of multiple sclerosis. (16365804)
2005
34
Analysis of IL4R haplotypes in predisposition to multiple sclerosis. (14712310)
2004
35
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope. (12965253)
2003
36
Experience with high-dose immunosuppressive therapy followed by transplantation of autologous stem hematopoietic cells in patients with multiple sclerosis]. (12181832)
2002
37
Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. (12445803)
2002
38
Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis. (11571703)
2001
39
Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis. (11694330)
2001
40
Dynamics of the reactivity to MBP in multiple sclerosis. (10871786)
2000
41
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
42
Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis. (10027703)
1999
43
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. (10079101)
1999
44
Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. (9258768)
1997
45
Increase of interleukin-2 soluble receptors in multiple sclerosis: preliminary study in 26 patients]. (7826250)
1994
46
Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. (7504688)
1993
47
Intermittent interferonemia and interferon responses in multiple sclerosis. (1701372)
1991
48
Natural killer (NK) cells in chronic progressive multiple sclerosis patients treated with lymphoblastoid interferon. (3183034)
1988
49
Preliminary trial of poly ICLC in chronic progressive multiple sclerosis. (3960323)
1986
50
Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. (6607973)
1983

Variations for Multiple Sclerosis

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Expression for genes affiliated with Multiple Sclerosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Search GEO for disease gene expression data for Multiple Sclerosis.

Pathways for genes affiliated with Multiple Sclerosis

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Compounds for genes affiliated with Multiple Sclerosis

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GO Terms for genes affiliated with Multiple Sclerosis

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Products for genes affiliated with Multiple Sclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet