MS
MCID: MLT020
MIFTS: 74

Multiple Sclerosis (MS) malady

Neuronal category

Summaries for Multiple Sclerosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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MedlinePlus:34 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and neuromyelitis optica. An important gene associated with Multiple Sclerosis is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are Influenza A and Leishmaniasis. The drugs cyclophosphamide and hydroxocobalamin and the compounds lipid and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and reproductive system.

Disease Ontology:8 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

NIH Rare Diseases:43 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:44 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Genetics Home Reference:21 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

Wikipedia:64 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Description from OMIM:47 612594,612596,126200,612595,614810

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

Sources:
8Disease Ontology, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT, 47OMIM, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

multiple sclerosis 8 19 43 20 21 44 10 45 34 31 61
ms 19 43 21
generalized multiple sclerosis 8
multiple sclerosis nos 8
disseminated sclerosis 21
insular sclerosis 8


External Ids:

Disease Ontology8 DOID:2377
NCIt40 C3243
ICD9CM27 340
MeSH35 D009103
ICD1025 G35

Related Diseases for Multiple Sclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Multiple Sclerosis family:

primary progressive multiple sclerosis multiple sclerosis 4
multiple sclerosis 3 multiple sclerosis 1
multiple sclerosis 2 multiple sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 488)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis31.9IFNB1, MOG, MBP
2neuromyelitis optica31.3MOG, MBP, IFNB1
3primary progressive multiple sclerosis31.1MOG, IFNB1, MBP
4secondary progressive multiple sclerosis31.0MBP, IFNB1
5acute disseminated encephalomyelitis31.0MBP, MOG
6myelitis30.8MBP
7alzheimer's disease30.7C5AR1
8systemic lupus erythematosus30.6IFNB1, IL17A, C5AR1, C3, CIITA, IL12B
9arthritis30.6CIITA, IL17A, C5AR1, C3, GABBR1
10measles30.5MBP, IFNB1, CIITA, IL12B
11tropical spastic paraparesis30.5MBP, IFNB1
12subacute sclerosing panencephalitis30.5MOG, MBP
13vasculitis30.4C3, IL17A
14chronic inflammatory demyelinating polyradiculoneuropathy30.3IFNB1
15celiac disease30.2TAGAP, CIITA
16tetanus30.1MOG, MBP, CIITA, GABBR1
17lyme disease30.1CIITA, MBP
18tuberculosis29.8IL17A, IFNB1, C3, CIITA, MBP, C5AR1
19hepatitis c29.8IFNB1, MBP, CIITA, IL12B
20asthma29.7IL17A, MBP, C5AR1, CIITA, IFNB1, IL12B
21pediatric multiple sclerosis10.9
22venous insufficiency10.9
23multiple sclerosis 110.9
24spasticity10.8
25allergic encephalomyelitis10.7
26multiple sclerosis 210.7
27progressive relapsing multiple sclerosis10.6
28neurologic diseases10.6
29progressive multifocal leukoencephalopathy10.6
30cerebral atrophy10.6
31trigeminal neuralgia10.5
32n syndrome10.5
33infectious mononucleosis10.5
34autonomic dysfunction10.5
35brain disease10.5
36uveitis10.5
37transverse myelitis10.5
38memory impairment10.5
39tremor10.5
40restless legs syndrome10.4
41spastic paraparesis10.4
42hematopoietic stem cell transplantation10.4
43neurogenic bladder10.4
44parkinson's disease10.4
45familial mediterranean fever10.4
46lateral sclerosis10.4
47amyotrophic lateral sclerosis10.4
48sleep disorder10.4
49guillain-barr� syndrome10.4
50internuclear ophthalmoplegia10.3

Graphical network of the top 20 diseases related to Multiple Sclerosis:



Diseases related to multiple sclerosis

Clinical Features for Multiple Sclerosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612594,612596,126200,612595,614810

Drugs & Therapeutics for Multiple Sclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple Sclerosis

Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Search CenterWatch for Multiple Sclerosis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

Sources:
20GeneTests
See all sources

Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis20

Anatomical Context for Multiple Sclerosis

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Multiple Sclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1C3, MOG, IFNB1, MBP, CIITA, IL12B
2MP:000538911.8MBP, GABBR1, TALDO1, TAGAP, C5AR1, C3
3MP:000539711.7MOG, IFNB1, MBP, CIITA, IL12B, IL17A

Publications for Multiple Sclerosis

Sources:
51PubMed
See all sources

Articles related to Multiple Sclerosis:

(show top 50)    (show all 4773)
idTitleAuthorsYear
1
Cost effectiveness of a pragmatic exercise intervention (EXIMS) for people with multiple sclerosis: economic evaluation of a randomised controlled trial. (24421304)
2014
2
Physical trauma and risk of multiple sclerosis: A systematic review and meta-analysis of observational studies. (24246497)
2014
3
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. (23225573)
2013
4
Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. (23441184)
2013
5
Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients. (23439581)
2013
6
Histone deacetylase gene variants predict brain volume changes in multiple sclerosis. (22884548)
2013
7
Lessons learned from fatal progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab. (23338729)
2013
8
Autologous hematopoietic stem cell transplantation as a treatment option for aggressive multiple sclerosis. (23637027)
2013
9
Mortality following a brain tumour diagnosis in patients with multiple sclerosis. (24220114)
2013
10
Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis. (23186557)
2013
11
Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. (22539566)
2012
12
A patient with both narcolepsy and multiple sclerosis in association with Pandemrix vaccination. (22841884)
2012
13
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (21833088)
2011
14
Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis. (21251115)
2011
15
Multiple sclerosis and cognitive decline: is ApoE-4 a surrogate marker? (21208197)
2011
16
Anaphylactic reaction after injection of glatiramer acetate (CopaxoneAr) in patients with relapsing-remitting multiple sclerosis. (22123157)
2011
17
Simvastatin as add-on therapy to interferon I^-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial. (21742556)
2011
18
Injectable disease-modifying therapy for relapsing-remitting multiple sclerosis: a review of adherence data. (21049828)
2010
19
Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. (20122699)
2010
20
Paraoxonase 1 polymorphisms are not related with the risk for multiple sclerosis. (19826962)
2010
21
Interferon beta-1a induces tumor necrosis factor receptor 1 but decreases tumor necrosis factor receptor 2 leukocyte mRNA levels in relapsing-remitting multiple sclerosis. (19246939)
2009
22
Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study. (19201654)
2009
23
Serum levels of CXCL13 are elevated in active multiple sclerosis. (19805441)
2009
24
TGF-beta as a promising option in the treatment of multiple sclerosis. (19285095)
2009
25
Brain multiple sclerosis-like lesions in a patient with Muckle-Wells syndrome. (19828598)
2009
26
Pediatric multiple sclerosis. (19364455)
2009
27
Multiple sclerosis-like disorder in OPA1-related autosomal dominant optic atrophy. (18287570)
2008
28
Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients. (18382694)
2008
29
HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. (18656179)
2008
30
CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis. (18208868)
2008
31
Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue. (18297277)
2008
32
Inhibitory effect of polyunsaturated fatty acids on MMP-9 release from microglial cells--implications for complementary multiple sclerosis treatment. (17624613)
2007
33
A case study: identifying alcohol abuse in multiple sclerosis. (18186422)
2007
34
Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients. (17126411)
2007
35
Future-directed thinking and depression in relapsing-remitting multiple sclerosis. (17032490)
2006
36
Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. (16753227)
2006
37
Ctla4 and multiple sclerosis in the Italian population. (15596061)
2005
38
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. (15778405)
2005
39
Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients. (16053472)
2005
40
Promoter polymorphism of IL-10 and severity of multiple sclerosis. (14616291)
2003
41
CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis. (12458055)
2002
42
Continuous facial myokymia in multiple sclerosis: treatment with botulinum toxin. (10765052)
2000
43
Multiple sclerosis: the increased frequency of the ICAM-1 exon 6 gene point mutation genetic type K469. (9667594)
1998
44
Conversion disorder presenting as multiple sclerosis. (9795550)
1998
45
Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis and their application for new therapeutic strategies. (9266414)
1997
46
Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. (9225688)
1997
47
Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis. (8862139)
1996
48
Rapid normalization of visual evoked potentials by picoTesla range magnetic fields in chronic progressive multiple sclerosis. (7814217)
1994
49
Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. (7820569)
1994
50
Interferon-gamma, interleukin-4 and transforming growth factor-beta mRNA expression in multiple sclerosis and myasthenia gravis. (7732782)
1994

Genetic Variations for Multiple Sclerosis

Expression for genes affiliated with Multiple Sclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Search GEO for disease gene expression data for Multiple Sclerosis.

Pathways for genes affiliated with Multiple Sclerosis

Sources:
30KEGG
See all sources

Pathways related to Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4PVRL2, IFNB1, CIITA, IL12B, C3
2
Hide members
11.2CIITA, IL12B, IL17A, C3
311.2IFNB1, CIITA, IL12B, C3

Compounds for genes affiliated with Multiple Sclerosis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1lipid4512.4MBP, CIITA, IL12B, IL17A, C3, IFNB1
2tyrosine4512.3C5AR1, CIITA, IL17A, CD6, PVRL2, IFNB1
3rantes4511.8C5AR1, IFNB1, CIITA, IL12B, IL17A
4pge24511.8IFNB1, IL12B, CIITA, IL17A, C5AR1
5cysteine4511.8C5AR1, C3, MBP, CIITA, GABBR1, IFNB1
6glucose4511.7MOG, IFNB1, CIITA, TALDO1, C3, GABBR1
7creatinine4511.7IFNB1, MBP, C3, IL17A, C5AR1
8glatiramer acetate45 1112.6MOG, CIITA, MBP, IFNB1
9sb 20358045 6012.4C5AR1, IFNB1, IL12B, IL17A
10polyinosinic-polycytidylic acid4511.4IL12B, CIITA, IFNB1
11peptidoglycan45 2912.4IL12B, IFNB1, CIITA
12ccl445 2912.3IL12B, IL17A, IFNB1
13silver4511.2MOG, MBP, IFNB1
14compstatin6011.2C3, C5AR1
15ndt 95137276011.2C3, C5AR1
16compstatin control peptide6011.2C3, C5AR1
17edss4511.2MBP, IFNB1
18plp (139-151)6011.2MBP, MOG
19mog (35-55)6011.2MBP, MOG
20nogo-66 (1-40)6011.2MBP, MOG
21c3bot (154-182)6011.1MOG, MBP
22ono 25066011.1MOG, MBP
23endotoxin4511.1CIITA
24sodium dodecylsulfate4511.0MBP, IL12B, CIITA
25pd 98,0594510.9IL17A, IL12B, IFNB1, C5AR1
26mezerein4510.9IFNB1, MBP
27cycloheximide4510.9IFNB1
282,3-cyclic nucleotide4510.9MOG, MBP
29pmsf4510.9C5AR1, MBP

GO Terms for genes affiliated with Multiple Sclerosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.4CIITA, MBP, C3, C5AR1, IL17A
2positive regulation of osteoclast differentiationGO:04567210.9IL17A, IL12B
3positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.8IL12B, PVRL2
4natural killer cell activationGO:03010110.6IL12B, IFNB1

Products for genes affiliated with Multiple Sclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet