MS
MCID: MLT020
MIFTS: 82

Multiple Sclerosis (MS) malady

Neuronal diseases category

Summaries for Multiple Sclerosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and encephalomyelitis. An important gene associated with Multiple Sclerosis is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are Influenza A and Leishmaniasis. The drugs azathioprine and baclofen and the compounds lipid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are immune system and reproductive system.

Disease Ontology:8 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

NIH Rare Diseases:42 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:43 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Genetics Home Reference:21 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

Wikipedia:63 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Description from OMIM:46 612594,612596,126200,612595,614810

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

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Sources:
8Disease Ontology, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 46OMIM, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

multiple sclerosis 8 19 42 20 21 43 10 44 33 30 60
ms 19 42 21
generalized multiple sclerosis 8
multiple sclerosis nos 8
disseminated sclerosis 21
insular sclerosis 8


External Ids:

Disease Ontology8 DOID:2377
NCIt39 C3243
ICD9CM27 340
MeSH34 D009103
ICD1025 G35

Related Diseases for Multiple Sclerosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Multiple Sclerosis family:

Primary Progressive Multiple Sclerosis Multiple Sclerosis 4
Multiple Sclerosis 3 Multiple Sclerosis 1
Multiple Sclerosis 2 Multiple Sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis31.9MBP, IFNB1, MOG
2encephalomyelitis31.4MOG, IFNB1, MBP, CIITA, IL17A, C5AR1
3optic neuritis31.3MBP, IFNB1, MOG
4neuritis31.3MBP, CIITA
5neuromyelitis optica31.2MOG, IFNB1, MBP
6primary progressive multiple sclerosis31.0MBP, IFNB1, MOG
7secondary progressive multiple sclerosis31.0MBP, IFNB1
8acute disseminated encephalomyelitis30.9MOG, MBP
9myelitis30.8MBP
10encephalitis30.6MOG, MBP, CIITA, IL12B, IL17A, C5AR1
11lupus erythematosus30.6C3
12systemic lupus erythematosus30.6IFNB1, CIITA, IL12B, IL17A, C5AR1, C3
13arthritis30.6GABBR1, CIITA, IL17A, C5AR1, C3
14alzheimer's disease30.5C5AR1
15rheumatoid arthritis30.5MOG, IFNB1, CIITA, IL12B, IL17A, C5AR1
16measles30.5IL12B, CIITA, MBP, IFNB1
17central nervous system disease30.5IL17A, MBP, MOG
18tropical spastic paraparesis30.5IFNB1, MBP
19myasthenia gravis30.4MBP, MOG
20subacute sclerosing panencephalitis30.4MBP, MOG
21vasculitis30.4C3, IL17A
22hepatitis30.2IFNB1
23sarcoidosis30.2IL12B
24chronic inflammatory demyelinating polyradiculoneuropathy30.2IFNB1
25diabetes mellitus30.2C3
26herpes simplex30.2PVRL2, IFNB1, IL12B
27celiac disease30.2TAGAP, CIITA
28tetanus30.0MOG, MBP, GABBR1, CIITA
29lyme disease30.0CIITA, MBP
30hepatitis b29.9CIITA, MBP, MOG
31tuberculosis29.8IFNB1, MBP, CIITA, IL12B, IL17A, C5AR1
32ischemia29.8GABBR1, CIITA, IL17A, C5AR1
33guillain-barre syndrome29.8MBP, MOG
34dermatitis29.8IL17A
35hepatitis c29.8IFNB1, MBP, CIITA, IL12B
36asthma29.7IFNB1, MBP, CIITA, IL12B, IL17A, C5AR1
37venous insufficiency10.8
38cerebritis10.7
39progressive relapsing multiple sclerosis10.7
40retinitis10.6
41neuronitis10.6
42neurologic diseases10.6
43progressive multifocal leukoencephalopathy10.5
44trigeminal neuralgia10.5
45infectious mononucleosis10.5
46brain disease10.4
47cervicitis10.4
48uveitis10.4
49leukemia10.4
50restless legs syndrome10.4

Graphical network of the top 20 diseases related to Multiple Sclerosis:



Diseases related to multiple sclerosis

Clinical Features for Multiple Sclerosis

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

612594,612596,126200,612595,614810

Drugs & Therapeutics for Multiple Sclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple Sclerosis

Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Search CenterWatch for Multiple Sclerosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19478280
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

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Sources:
20GeneTests
See all sources

Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis20

Anatomical Context for Multiple Sclerosis

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Multiple Sclerosis:

32
T cells, Brain, Spinal cord, Bone, Testes, Monocytes, B cells, Endothelial, Thyroid, Bone marrow, Myeloid, Pituitary, Nk cells, Liver, Cortex, Skin, Eye, Lung, Heart, Cerebellum, Thymus, Pineal, Whole blood, Fetal brain, Thalamus, Hypothalamus, Pons, Ovary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Multiple Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1C3, MOG, IFNB1, MBP, CIITA, IL12B
2MP:000538911.8MBP, GABBR1, TALDO1, TAGAP, C5AR1, C3
3MP:000539711.7MOG, IFNB1, MBP, CIITA, IL12B, IL17A

Publications for Multiple Sclerosis

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Sources:
50PubMed
See all sources

Articles related to Multiple Sclerosis:

(show top 50)    (show all 4771)
idTitleAuthorsYear
1
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. (24270187)
2014
2
Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis. (24399825)
2014
3
Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system. (23609766)
2013
4
Pleuro-pericarditis, vasculitis, subendocardial and nodular biventricular fibrosis. The multiple faces of systemic sclerosis detected by cardiac magnetic resonance in the same patient. (22959868)
2013
5
Clinical case reviews in multiple sclerosis spasticity: experiences from around Europe. (24289846)
2013
6
SativexAr in multiple sclerosis spasticity: a cost-effectiveness model. (22681512)
2012
7
Perceived impact of spasticity is associated with spatial and temporal parameters of gait in multiple sclerosis. (22462022)
2012
8
Relevance of quality of life assessment for multiple sclerosis patients with memory impairment. (23239975)
2012
9
Complement regulator factor H in multiple sclerosis. (21618592)
2011
10
Balance Rehabilitation Unit (BRUa8c) posturography in relapsing-remitting multiple sclerosis. (21755127)
2011
11
Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals. (21664963)
2011
12
Health-related quality of life in relapsing remitting multiple sclerosis patients during treatment with glatiramer acetate: a prospective, observational, international, multi-centre study. (21078142)
2010
13
Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis. (20227772)
2010
14
Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. (20520825)
2010
15
TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. (18945822)
2009
16
Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (19667218)
2009
17
Risk alleles for multiple sclerosis in multiplex families. (19506219)
2009
18
Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment? (19695714)
2009
19
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. (18663124)
2008
20
No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis. (18632786)
2008
21
Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions. (18438950)
2008
22
Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis. (18398457)
2008
23
Reduction in magnetic resonance imaging T2 burden of disease in patients with relapsing-remitting multiple sclerosis: analysis of 48-week data from the EVIDENCE (EVidence of Interferon Dose-response: European North American Comparative Efficacy) study. (18426595)
2008
24
A biosensor-based characterization of the affinity maturation of the immune response against interferon-beta and correlations with neutralizing antibodies in treated multiple sclerosis patients. (18937545)
2008
25
The neurogenic bladder in multiple sclerosis: review of the literature and proposal of management guidelines. (17881401)
2007
26
Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population. (17509152)
2007
27
Autoantibodies to the proteasome in monosymptomatic optic neuritis may predict progression to multiple sclerosis. (17852796)
2007
28
The relationship between HLA-DRB1 alleles and optic neuritis in Irish patients and the risk of developing multiple sclerosis. (17895416)
2007
29
The expression of BAFF-binding receptors is not altered in multiple sclerosis or myasthenia gravis. (17444957)
2007
30
Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. (17709711)
2007
31
CD24 Ala/Val polymorphism and multiple sclerosis. (16631259)
2006
32
Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis. (15704220)
2005
33
Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. (15020063)
2004
34
Childhood chronic inflammatory demyelinating polyneuropathy with central nervous system demyelination resembling multiple sclerosis. (12565914)
2003
35
Autonomic dysfunction in multiple sclerosis. (23649115)
2003
36
Glucocorticoid and type 1 interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis. (11447332)
2001
37
Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. (11353727)
2001
38
Molecular characterization of HERV-H variants associated with multiple sclerosis. (10770518)
2000
39
Induction of IL-1 receptor antagonist by interferon beta: implication for the treatment of multiple sclerosis. (10871782)
2000
40
Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. (10190821)
1999
41
Effect of 1-year treatment with interferon-beta1b on thyroid function and autoimmunity in patients with multiple sclerosis. (10526243)
1999
42
Infection and multiple sclerosis]. (10377791)
1999
43
Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis. (9655468)
1998
44
Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. (9012830)
1997
45
Cerebrospinal fluid analysis differentiates between relapsing-remitting and secondary progressive multiple sclerosis. (9343121)
1997
46
Characterization of the mitochondrial DNA in patients with multiple sclerosis. (8866430)
1996
47
HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genes in Japanese multiple sclerosis patients. (1926126)
1991
48
Characterization of myelin basic protein catabolism products in the cerebrospinal fluid from multiple sclerosis, stroke and head injury patients. (20504705)
1991
49
Magnetic resonance imaging in infections of the brain: findings in tuberculosis, listeriosis, toxoplasmosis, subacute sclerosing panencephalitis, and multiple sclerosis. (3455473)
1987
50
HLA-A3 linked C3 deficiency in multiple sclerosis. (901638)
1977

Genetic Variations for Multiple Sclerosis

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Expression for genes affiliated with Multiple Sclerosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Search GEO for disease gene expression data for Multiple Sclerosis.

Pathways for genes affiliated with Multiple Sclerosis

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Sources:
29KEGG
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Pathways related to Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4C3, IL12B, CIITA, IFNB1, PVRL2
2
Hide members
11.2CIITA, IL12B, IL17A, C3
311.2C3, IL12B, CIITA, IFNB1

Compounds for genes affiliated with Multiple Sclerosis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1lipid4412.4MOG, IFNB1, MBP, CIITA, IL12B, IL17A
2tyrosine4412.3PVRL2, IFNB1, MBP, GABBR1, CIITA, CD6
3rantes4411.8IFNB1, CIITA, IL12B, IL17A, C5AR1
4pge24411.8C5AR1, IL17A, IL12B, CIITA, IFNB1
5cysteine4411.8IFNB1, MBP, GABBR1, CIITA, C5AR1, C3
6glucose4411.7MOG, IFNB1, GABBR1, CIITA, TALDO1, C3
7creatinine4411.7IFNB1, MBP, IL17A, C5AR1, C3
8glatiramer acetate44 1112.6CIITA, MBP, IFNB1, MOG
9sb 20358044 5912.4IFNB1, IL12B, IL17A, C5AR1
10polyinosinic-polycytidylic acid4411.4IFNB1, CIITA, IL12B
11peptidoglycan44 2812.4IL12B, CIITA, IFNB1
12ccl444 2812.3IFNB1, IL12B, IL17A
13silver4411.2MBP, IFNB1, MOG
14compstatin control peptide5911.2C5AR1, C3
15ndt 95137275911.2C5AR1, C3
16compstatin5911.2C5AR1, C3
17edss4411.2IFNB1, MBP
18c3bot (154-182)5911.2MOG, MBP
19ono 25065911.2MOG, MBP
20nogo-66 (1-40)5911.2MOG, MBP
21mog (35-55)5911.1MOG, MBP
22plp (139-151)5911.1MOG, MBP
23endotoxin4411.1CIITA
24sodium dodecylsulfate4411.0IL12B, CIITA, MBP
25pd 98,0594410.9IFNB1, IL12B, IL17A, C5AR1
26mezerein4410.9MBP, IFNB1
27cycloheximide4410.9IFNB1
282,3-cyclic nucleotide4410.9MOG, MBP
29pmsf4410.9C5AR1, MBP

GO Terms for genes affiliated with Multiple Sclerosis

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Sources:
16Gene Ontology
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Biological processes related to Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.4C3, C5AR1, IL17A, CIITA, MBP
2positive regulation of osteoclast differentiationGO:04567210.9IL17A, IL12B
3positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.8PVRL2, IL12B
4natural killer cell activationGO:03010110.6IL12B, IFNB1

Products for genes affiliated with Multiple Sclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet