Multiple Sclerosis (MS) malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Multiple Sclerosis

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MedlinePlus:33 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards based summary: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and optic neuritis. An important gene associated with Multiple Sclerosis is IL17A (interleukin 17A), and among its related pathways are Cytokines and Inflammatory Response and Cytokine Network. The drugs cyclophosphamide and hydroxocobalamin and the compounds compstatin control peptide and ndt 9513727 have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:9 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Genetics Home Reference:22 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

NIH Rare Diseases:42 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerveÔÇÖs ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:43 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Wikipedia:64 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Descriptions from OMIM:46 126200,612594,612595,612596,614810

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

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Multiple Sclerosis, Aliases & Descriptions:

Name: Multiple Sclerosis 31 9 20 42 21 22 43 11 44 33 61
Ms 20 42 22
Generalized Multiple Sclerosis 9 61
Sclerosis, Disseminated 61
Disseminated Sclerosis 22
Insular Sclerosis 9


Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases

External Ids:

Disease Ontology9 DOID:2377
MeSH34 D009103
ICD9CM28 340
NCIt39 C3243
ICD1026 G35

Related Diseases for Multiple Sclerosis

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Diseases in the Multiple Sclerosis family:

Primary Progressive Multiple Sclerosis Multiple Sclerosis 4
Multiple Sclerosis 3 Multiple Sclerosis 1
Multiple Sclerosis 2 Multiple Sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 582)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis32.6MBP, IFNB1
2optic neuritis32.0MBP, IFNB1
3neuromyelitis optica32.0IFNB1, MBP
4neuritis32.0MBP, CIITA
5secondary progressive multiple sclerosis31.9MBP, IFNB1
6primary progressive multiple sclerosis31.8MBP, IFNB1
8tropical spastic paraparesis31.2MBP, IFNB1
9encephalitis31.2CIITA, IL17A, IL12B, C5AR1, MBP
10demyelinating disease31.2MBP, IL17A, IFNB1
11measles31.1CIITA, IFNB1, IL12B, MBP
12arthritis31.1CIITA, IL17A, C3, C5AR1, GABBR1
13chronic inflammatory demyelinating polyneuropathy31.1IFNB1
14systemic lupus erythematosus31.0CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
15rheumatoid arthritis30.9CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
16tetanus30.7MBP, GABBR1, CIITA
17leukemia30.7IFNB1, IL17A, IL12B, C5AR1, MBP
18lyme disease30.7CIITA, MBP
19type 1 diabetes mellitus30.7C3, IL12B, CIITA
20herpes simplex30.6PVRL2, IFNB1, IL12B
21psoriasis30.6CIITA, IL17A, IL12B
22hepatitis c30.5IL12B, IFNB1, CIITA
23ischemia30.4CIITA, IL17A, C5AR1, GABBR1
24atherosclerosis30.4CIITA, IL17A, IL12B, C3, C5AR1
25myocarditis30.3IFNB1, CIITA
26cholera30.3IFNB1, IL17A, C5AR1
27tuberculosis30.1CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
28asthma30.1CIITA, IFNB1, IL17A, IL12B, C5AR1, MBP
29pediatric multiple sclerosis11.0
31venous insufficiency10.9
34allergic encephalomyelitis10.7
35acute disseminated encephalomyelitis10.7
38progressive multifocal leukoencephalopathy10.6
39neurologic diseases10.6
40trigeminal neuralgia10.6
41cerebral atrophy10.6
43transverse myelitis10.5
44infectious mononucleosis10.5
46autonomic dysfunction10.5
47memory impairment10.5
50lupus erythematosus10.5

Graphical network of the top 20 diseases related to Multiple Sclerosis:

Diseases related to multiple sclerosis

Symptoms for Multiple Sclerosis

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Clinical features from OMIM:


Drugs & Therapeutics for Multiple Sclerosis

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Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

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Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis21

Anatomical Context for Multiple Sclerosis

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MalaCards organs/tissues related to Multiple Sclerosis:

T cells, Brain, Spinal cord, Bone, Testes, B cells, Monocytes, Endothelial, Bone marrow, Thyroid, Myeloid, Pituitary, Cortex, Nk cells, Eye, Neutrophil, Liver, Skin, Thymus, Cerebellum, Heart, Pineal, Whole blood, Lymph node, Lung, Ovary, Fetal brain, Thalamus, Hypothalamus, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

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MGI Mouse Phenotypes related to Multiple Sclerosis:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3MBP, CIITA, PADI2, IFNB1, IL17A, IL12B
2MP:00053879.3PADI2, IFNB1, IL17A, IL12B, C3, C5AR1
3MP:00053899.3PVRL2, C3, C5AR1, GABBR1, TALDO1, TAGAP
4MP:00053768.9CIITA, IFNB1, IL17A, IL12B, C3, C5AR1

Publications for Multiple Sclerosis

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Articles related to Multiple Sclerosis:

(show top 50)    (show all 4890)
Multiple sclerosis and oligodendroglioma: an exceptional association. (25180114)
Modelling the natural history of primary progressive multiple sclerosis. (24828900)
Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis. (24312102)
IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. (23726764)
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency in people with multiple sclerosis: a summary of a Cochrane systematic review. (23781006)
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations. (23602715)
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing-remitting multiple sclerosis patients. (23425504)
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. (23472185)
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. (23910387)
Methodological issues with the risk of relapse study in patients with multiple sclerosis after yellow fever vaccination. (22232361)
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients. (22608171)
Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains. (21737148)
Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis. (20051521)
Cerebellar information processing in relapsing-remitting multiple sclerosis (RRMS). (20714060)
Magnetic resonance imaging at first episode in pediatric multiple sclerosis retrospective evaluation according to KIDMUS and lesion dissemination in space criteria. (19682809)
Chronic cerebrospinal venous insufficiency and multiple sclerosis. (20373339)
Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. (20309394)
Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: is it a susceptibility gene? (20483145)
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. (19631393)
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis. (19039022)
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (19525953)
Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. (19251277)
In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. (17911184)
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
Cytokine changes during interferon-beta therapy in multiple sclerosis: correlations with interferon dose and MRI response. (17328965)
Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosis. (17273808)
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis. (16899302)
Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. (16400315)
Charles Bonnet syndrome associated with a first attack of multiple sclerosis. (16365804)
Analysis of IL4R haplotypes in predisposition to multiple sclerosis. (14712310)
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope. (12965253)
Experience with high-dose immunosuppressive therapy followed by transplantation of autologous stem hematopoietic cells in patients with multiple sclerosis]. (12181832)
Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. (12445803)
Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis. (11571703)
Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis. (11694330)
Dynamics of the reactivity to MBP in multiple sclerosis. (10871786)
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis. (10027703)
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. (10079101)
Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. (9258768)
Increase of interleukin-2 soluble receptors in multiple sclerosis: preliminary study in 26 patients]. (7826250)
Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. (7504688)
Intermittent interferonemia and interferon responses in multiple sclerosis. (1701372)
Natural killer (NK) cells in chronic progressive multiple sclerosis patients treated with lymphoblastoid interferon. (3183034)
Preliminary trial of poly ICLC in chronic progressive multiple sclerosis. (3960323)
Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. (6607973)

Variations for Multiple Sclerosis

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Expression for genes affiliated with Multiple Sclerosis

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2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Multiple Sclerosis patients vs. healthy controls: 31 (show all 332)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1HBDhemoglobin, deltaBlood+4.090.000
3ALAS2aminolevulinate, delta-, synthase 2Blood+3.750.000
4BOD1L1biorientation of chromosomes in cell division 1-like 1Blood+3.720.000
5FBXO11F-box protein 11Spinal Cord+3.700.005
6MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Blood+3.690.000
7CPT1Acarnitine palmitoyltransferase 1A (liver)Spinal Cord+3.620.004
8ZNF695zinc finger protein 695Spinal Cord-3.580.001
9WBP2NLWBP2 N-terminal likeSpinal Cord-3.430.015
10CLEC4AC-type lectin domain family 4, member ASpinal Cord+3.410.016
11SAMSN1SAM domain, SH3 domain and nuclear localization signals 1Blood+3.390.000
12PUS7pseudouridylate synthase 7 (putative)Spinal Cord+3.340.038
13SLC2A10solute carrier family 2 (facilitated glucose transporter), member 10Spinal Cord+3.330.006
14EIF5Aeukaryotic translation initiation factor 5ABlood-3.300.000
15CLCCharcot-Leyden crystal galectinBlood+3.200.000
16FAM118Afamily with sequence similarity 118, member ASpinal Cord-3.200.007
17HBMhemoglobin, muBlood+3.150.000
18HINT3histidine triad nucleotide binding protein 3Blood-3.100.000
19CAB39Lcalcium binding protein 39-likeSpinal Cord+3.070.000
20IGHDimmunoglobulin heavy constant deltaBlood+3.050.000
21MS4A3membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)Blood+2.990.000
22IL27RAinterleukin 27 receptor, alphaSpinal Cord+2.980.045
23SMAD5SMAD family member 5Spinal Cord+2.970.033
24PRKD3protein kinase D3Spinal Cord+2.950.011
25PNO1partner of NOB1 homolog (S. cerevisiae)Spinal Cord+2.950.036
26DOK6docking protein 6Spinal Cord-2.940.016
27IL8interleukin 8Blood+2.910.000
28FLJ44342uncharacterized LOC645460Spinal Cord+2.880.021
29KRTAP1-3keratin associated protein 1-3Spinal Cord-2.880.007
30CPA3carboxypeptidase A3 (mast cell)Blood+2.830.000
31PRPF4Bpre-mRNA processing factor 4BSpinal Cord+2.820.042
32TMEM39Atransmembrane protein 39ASpinal Cord+2.820.040
33ACACBacetyl-CoA carboxylase betaSpinal Cord+2.810.010
34RNF152ring finger protein 152Spinal Cord-2.800.026
35PHACTR2phosphatase and actin regulator 2Spinal Cord+2.790.041
36SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Blood+2.790.000
37MTUS2microtubule associated tumor suppressor candidate 2Spinal Cord-2.780.002
38LOC441052uncharacterized LOC441052Spinal Cord-2.760.003
39FAM161Afamily with sequence similarity 161, member ASpinal Cord-2.760.020
40AGBL3ATP/GTP binding protein-like 3Spinal Cord-2.750.037
41LOC284926uncharacterized LOC284926Spinal Cord-2.740.011
42ARIH2ariadne RBR E3 ubiquitin protein ligase 2Spinal Cord+2.740.006
43NUDT19nudix (nucleoside diphosphate linked moiety X)-type motif 19Spinal Cord+2.740.042
44SELENBP1selenium binding protein 1Blood+2.730.000
45PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)Spinal Cord-2.730.042
46GLIS3GLIS family zinc finger 3Spinal Cord+2.730.024
47HECTD4HECT domain containing E3 ubiquitin protein ligase 4Spinal Cord-2.730.010
48ANKRD7ankyrin repeat domain 7Spinal Cord-2.720.012
49LOC100506621uncharacterized LOC100506621Spinal Cord+2.710.047
50ZNF214zinc finger protein 214Spinal Cord-2.700.011
51G0S2G0/G1switch 2Blood+2.690.000
52GNASGNAS complex locusBlood+2.690.000
53AURKCaurora kinase CSpinal Cord-2.680.007
54LCORLligand dependent nuclear receptor corepressor-likeSpinal Cord+2.670.029
55ZNF253zinc finger protein 253Spinal Cord-2.670.034
56NRXN1neurexin 1Spinal Cord-2.660.014
57FRMD6FERM domain containing 6Spinal Cord+2.650.029
58ZDHHC21zinc finger, DHHC-type containing 21Spinal Cord-2.640.035
59GCSAMLgerminal center-associated, signaling and motility-likeSpinal Cord-2.640.015
60VPS13Bvacuolar protein sorting 13 homolog B (yeast)Spinal Cord+2.630.025
61AAK1AP2 associated kinase 1Spinal Cord-2.630.023
62WDR96WD repeat domain 96Spinal Cord+2.620.031
63KRT6Akeratin 6ASpinal Cord-2.620.004
64AGTR1angiotensin II receptor, type 1Spinal Cord+2.610.011
65H2AFYH2A histone family, member YSpinal Cord+2.610.016
66SKILSKI-like oncogeneSpinal Cord+2.600.025
67SUGT1P3SUGT1 pseudogene 3Spinal Cord-2.600.002
68ANKRD11ankyrin repeat domain 11Blood+2.590.000
69USP45ubiquitin specific peptidase 45Spinal Cord-2.590.043
70FAM84Afamily with sequence similarity 84, member ASpinal Cord-2.570.011
71FASFas cell surface death receptorSpinal Cord+2.570.040
72IL18R1interleukin 18 receptor 1Spinal Cord-2.570.044
73CDH26cadherin 26Spinal Cord-2.570.025
74SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Spinal Cord-2.570.025
75IL31RAinterleukin 31 receptor ASpinal Cord-2.570.027
76ITGBL1integrin, beta-like 1 (with EGF-like repeat domains)Spinal Cord+2.570.018
77STRAPserine/threonine kinase receptor associated proteinBlood+2.550.000
78AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1Spinal Cord-2.550.037
79PLCL2phospholipase C-like 2Spinal Cord+2.530.027
80SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2Spinal Cord+2.530.026
81CC2D2Acoiled-coil and C2 domain containing 2ASpinal Cord+2.530.020
82ODF2outer dense fiber of sperm tails 2Spinal Cord-2.530.035
83CCDC120coiled-coil domain containing 120Spinal Cord-2.520.024
84GSPT2G1 to S phase transition 2Spinal Cord+2.520.038
85SMC1Astructural maintenance of chromosomes 1ASpinal Cord+2.520.002
86COA7cytochrome c oxidase assembly factor 7 (putative)Spinal Cord+2.510.033
87C5orf58chromosome 5 open reading frame 58Spinal Cord-2.500.036
88FAM53Bfamily with sequence similarity 53, member BSpinal Cord-2.500.012
89C11orf70chromosome 11 open reading frame 70Spinal Cord+2.500.040
90HBBhemoglobin, betaBlood+2.490.000
91LTN1listerin E3 ubiquitin protein ligase 1Spinal Cord-2.490.022
92UNC13Cunc-13 homolog C (C. elegans)Spinal Cord-2.490.030
93FCRL1Fc receptor-like 1Blood+2.490.000
94DMRT1doublesex and mab-3 related transcription factor 1Spinal Cord-2.490.009
95SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1Blood+2.490.001
96CSNK2A1casein kinase 2, alpha 1 polypeptideSpinal Cord+2.480.035
97KLF5Kruppel-like factor 5 (intestinal)Spinal Cord-2.480.017
98HELLShelicase, lymphoid-specificSpinal Cord-2.470.043
99ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12Spinal Cord-2.470.004
100THOC5THO complex 5Spinal Cord-2.470.046
101GPR17G protein-coupled receptor 17Spinal Cord-2.450.031
102CA1carbonic anhydrase IBlood+2.440.003
103LOC100294362uncharacterized LOC100294362Spinal Cord-2.440.047
104TMC5transmembrane channel-like 5Spinal Cord-2.430.020
105SPTAN1spectrin, alpha, non-erythrocytic 1Spinal Cord-2.430.007
106CNPY2canopy FGF signaling regulator 2Spinal Cord-2.430.047
107AFF3AF4/FMR2 family, member 3Spinal Cord-2.430.017
108SLC44A3solute carrier family 44, member 3Spinal Cord+2.420.046
109MBTD1mbt domain containing 1Spinal Cord-2.400.046
110RPS15Aribosomal protein S15aSpinal Cord-2.400.028
111DZANK1double zinc ribbon and ankyrin repeat domains 1Spinal Cord-2.390.033
112ONECUT2one cut homeobox 2Spinal Cord-2.390.015
113IGHMimmunoglobulin heavy constant muBlood+2.390.001
114ZNF169zinc finger protein 169Spinal Cord-2.380.019
115WDR19WD repeat domain 19Spinal Cord-2.380.028
116COQ10Bcoenzyme Q10 homolog B (S. cerevisiae)Spinal Cord-2.380.029
117CEP128centrosomal protein 128kDaSpinal Cord+2.380.022
118ZDHHC24zinc finger, DHHC-type containing 24Spinal Cord-2.370.008
119C17orf98chromosome 17 open reading frame 98Spinal Cord-2.350.028
120CSMD1CUB and Sushi multiple domains 1Spinal Cord-2.350.044
121DOCK5dedicator of cytokinesis 5Spinal Cord-2.350.014
122HIST1H3Fhistone cluster 1, H3fSpinal Cord-2.340.040
123LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood-2.340.000
124CCDC67coiled-coil domain containing 67Spinal Cord-2.340.047
125LOC284578uncharacterized LOC284578Spinal Cord-2.330.037
126LOC286058uncharacterized LOC286058Spinal Cord-2.330.027
127MROH2Amaestro heat-like repeat family member 2ASpinal Cord+2.320.022
128RNF113Aring finger protein 113ASpinal Cord+2.300.026
129PYGO1pygopus family PHD finger 1Spinal Cord+2.290.035
130MRPL44mitochondrial ribosomal protein L44Spinal Cord+2.290.043
131ARF6ADP-ribosylation factor 6Blood-2.290.000
132DNAH5dynein, axonemal, heavy chain 5Spinal Cord-2.290.013
133M1APmeiosis 1 associated proteinSpinal Cord-2.280.019
134HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupledSpinal Cord-2.260.049
135LYRM7LYR motif containing 7Spinal Cord-2.260.022
136NAP1L4nucleosome assembly protein 1-like 4Spinal Cord-2.260.017
137TMEM52transmembrane protein 52Spinal Cord-2.260.027
138TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Blood+2.250.000
139LOC100287387uncharacterized LOC100287387Spinal Cord-2.230.036
140C10orf95chromosome 10 open reading frame 95Spinal Cord-2.230.022
141ALYREFAly/REF export factorBlood-2.230.000
142B3GALNT2beta-1,3-N-acetylgalactosaminyltransferase 2Spinal Cord+2.220.018
143HN1Lhematological and neurological expressed 1-likeSpinal Cord-2.220.028
144CCDC17coiled-coil domain containing 17Spinal Cord-2.220.037
145LINC00474long intergenic non-protein coding RNA 474Spinal Cord-2.220.033
146AP3B2adaptor-related protein complex 3, beta 2 subunitSpinal Cord-2.210.017
147CD24CD24 moleculeBlood+2.210.001
148HOXD4homeobox D4Spinal Cord-2.200.012
149TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)Spinal Cord+2.200.024
150FAM78Bfamily with sequence similarity 78, member BSpinal Cord-2.190.034
151CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+2.180.006
152SRRM2serine/arginine repetitive matrix 2Blood+2.180.003
153RICTORRPTOR independent companion of MTOR, complex 2Spinal Cord+2.170.049
154SMR3Asubmaxillary gland androgen regulated protein 3ASpinal Cord-2.170.032
155SNX20sorting nexin 20Blood-2.170.000
156TBX3T-box 3Spinal Cord-2.170.016
157MMP17matrix metallopeptidase 17 (membrane-inserted)Spinal Cord-2.140.011
158SLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2Spinal Cord+2.140.046
159SYNE2spectrin repeat containing, nuclear envelope 2Blood+2.140.007
160FAM111Afamily with sequence similarity 111, member ASpinal Cord+2.130.034
161SSBP1single-stranded DNA binding protein 1, mitochondrialSpinal Cord-2.130.048
162THRAP3thyroid hormone receptor associated protein 3Blood+2.120.002
163CYTH2cytohesin 2Spinal Cord-2.120.024
164TULP4tubby like protein 4Spinal Cord-2.120.041
165INSL6insulin-like 6Spinal Cord+2.120.048
166GM2AGM2 ganglioside activatorBlood-2.110.001
167LOC283674uncharacterized LOC283674Spinal Cord-2.100.039
168MSH6mutS homolog 6Spinal Cord-2.090.035
169RIF1RAP1 interacting factor homolog (yeast)Blood+2.090.005
170CASP2caspase 2, apoptosis-related cysteine peptidaseBlood-2.070.000
171KIAA1217KIAA1217Spinal Cord+2.070.035
172EPB42erythrocyte membrane protein band 4.2Blood+2.060.014
173TMEM88transmembrane protein 88Spinal Cord-2.060.021
174FCARFc fragment of IgA, receptor forBlood-2.050.000
175AHSPalpha hemoglobin stabilizing proteinBlood+2.040.008
176ATRXalpha thalassemia/mental retardation syndrome X-linkedBlood+2.040.002
177TTC26tetratricopeptide repeat domain 26Spinal Cord-2.040.020
178CLNKcytokine-dependent hematopoietic cell linkerSpinal Cord-2.030.048
179COL8A1collagen, type VIII, alpha 1Spinal Cord+2.020.048
180SLC2A4solute carrier family 2 (facilitated glucose transporter), member 4Spinal Cord-2.020.044
181MOB3AMOB kinase activator 3ABlood-2.010.000
182NR4A2nuclear receptor subfamily 4, group A, member 2Blood+2.010.002
183CROCCciliary rootlet coiled-coil, rootletinSpinal Cord-2.010.029
184QSER1glutamine and serine rich 1Blood+2.010.004
185CD22CD22 moleculeBlood+2.000.001
186CD200CD200 moleculeBlood+1.990.002
187BTBD11BTB (POZ) domain containing 11Spinal Cord+1.990.040
188EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaBlood-1.970.000
190NAALADL2N-acetylated alpha-linked acidic dipeptidase-like 2Spinal Cord-1.960.044
191RBM25RNA binding motif protein 25Blood+1.960.001
192UBA6ubiquitin-like modifier activating enzyme 6Blood-1.960.010
193MS4A1membrane-spanning 4-domains, subfamily A, member 1Blood+1.960.011
194SNRNP40small nuclear ribonucleoprotein 40kDa (U5)Blood-1.960.000
195EBF1early B-cell factor 1Blood+1.960.003
196MASP2mannan-binding lectin serine peptidase 2Spinal Cord-1.960.017
197ZMIZ2zinc finger, MIZ-type containing 2Spinal Cord-1.950.038
198SNORA28small nucleolar RNA, H/ACA box 28Blood+1.950.001
199ZNF445zinc finger protein 445Spinal Cord+1.950.049
200FCRL2Fc receptor-like 2Blood+1.950.003
201RGS14regulator of G-protein signaling 14Spinal Cord-1.940.038
202GLRA3glycine receptor, alpha 3Spinal Cord-1.940.041
203SLAMF9SLAM family member 9Spinal Cord-1.930.024
204TMEM150Ctransmembrane protein 150CSpinal Cord+1.930.022
205KRT4keratin 4Spinal Cord-1.930.011
206PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozymeSpinal Cord+1.930.024
207C1orf174chromosome 1 open reading frame 174Blood-1.920.001
208TCL1AT-cell leukemia/lymphoma 1ABlood+1.920.013
209MAT2Amethionine adenosyltransferase II, alphaBlood-1.920.000
210MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 1Spinal Cord+1.920.044
211TBL1Xtransducin (beta)-like 1X-linkedBlood+1.910.012
212C22orf26chromosome 22 open reading frame 26Spinal Cord-1.910.043
213PKP4plakophilin 4Spinal Cord-1.890.027
214POLKpolymerase (DNA directed) kappaBlood-1.890.000
215HS2ST1heparan sulfate 2-O-sulfotransferase 1Spinal Cord+1.880.020
216VWA1von Willebrand factor A domain containing 1Spinal Cord-1.870.038
218CNKSR1connector enhancer of kinase suppressor of Ras 1Spinal Cord-1.840.032
219PCDH9protocadherin 9Blood+1.840.025
220USP21ubiquitin specific peptidase 21Spinal Cord+1.830.027
222IFIT5interferon-induced protein with tetratricopeptide repeats 5Spinal Cord+1.830.046
223KLF13Kruppel-like factor 13Blood+1.830.005
224HIF3Ahypoxia inducible factor 3, alpha subunitSpinal Cord-1.820.042
225SLC25A37solute carrier family 25 (mitochondrial iron transporter), member 37Spinal Cord-1.810.050
226GATA2GATA binding protein 2Blood+1.810.000
227TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)Blood-1.800.000
228ELAVL3ELAV like neuron-specific RNA binding protein 3Spinal Cord-1.790.042
229TEX10testis expressed 10Blood+1.790.003
230KCNE3potassium voltage-gated channel, Isk-related family, member 3Blood-1.770.001
231SF1splicing factor 1Blood+1.770.015
232LOC100134445uncharacterized LOC100134445Blood+1.770.000
233FCRLAFc receptor-like ABlood+1.760.012
234SNCAsynuclein, alpha (non A4 component of amyloid precursor)Blood+1.750.022
235KLHL14kelch-like family member 14Blood+1.750.006
236PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alphaBlood-1.740.001
237MS4A6Amembrane-spanning 4-domains, subfamily A, member 6ABlood-1.740.004
238FAM129Cfamily with sequence similarity 129, member CBlood+1.740.006
239ANKRD12ankyrin repeat domain 12Blood+1.730.032
240STAP1signal transducing adaptor family member 1Blood+1.730.005
241ARPC4actin related protein 2/3 complex, subunit 4, 20kDaBlood-1.730.000
242MDM4MDM4, p53 regulatorBlood-1.730.000
243F5coagulation factor V (proaccelerin, labile factor)Blood+1.710.016
244BACH2BTB and CNC homology 1, basic leucine zipper transcription factor 2Blood+1.710.006
245C17orf103chromosome 17 open reading frame 103Spinal Cord-1.700.045
246KLHDC10kelch domain containing 10Blood+1.700.028
247PPP6R3protein phosphatase 6, regulatory subunit 3Blood-1.690.011
248VPREB3pre-B lymphocyte 3Blood+1.690.014
249STRADBSTE20-related kinase adaptor betaBlood+1.690.011
250LAMP1lysosomal-associated membrane protein 1Blood-1.690.007
251SERPINB9serpin peptidase inhibitor, clade B (ovalbumin), member 9Blood-1.680.000
252NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zetaBlood+1.670.008
253SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1Blood-1.670.002
254CLEC7AC-type lectin domain family 7, member ABlood-1.670.000
255TBL1XR1transducin (beta)-like 1 X-linked receptor 1Blood+1.670.011
256PRF1perforin 1 (pore forming protein)Blood-1.670.023
257EGR1early growth response 1Blood+1.670.017
258FCRL5Fc receptor-like 5Blood+1.650.038
259C21orf33chromosome 21 open reading frame 33Blood-1.650.001
260STAT2signal transducer and activator of transcription 2, 113kDaBlood-1.640.000
261BANK1B-cell scaffold protein with ankyrin repeats 1Blood+1.620.015
262STT3ASTT3A, subunit of the oligosaccharyltransferase complex (catalytic)Blood-1.610.000
263OSBPL10oxysterol binding protein-like 10Blood+1.600.024
264ADAM9ADAM metallopeptidase domain 9Blood-1.600.001
265ACTBactin, betaBlood-1.590.002
266UBN1ubinuclein 1Blood+1.580.019
267STRBPspermatid perinuclear RNA binding proteinBlood+1.580.006
268ICAM1intercellular adhesion molecule 1Blood-1.570.011
269EIF4A1eukaryotic translation initiation factor 4A1Blood+1.570.001
270HLA-DOBmajor histocompatibility complex, class II, DO betaBlood+1.570.019
271NUPL1nucleoporin like 1Blood+1.560.021
272HIPK3homeodomain interacting protein kinase 3Blood-1.560.007
273USP1ubiquitin specific peptidase 1Blood+1.550.006
274SLFN5schlafen family member 5Blood+1.540.024
275PTP4A1protein tyrosine phosphatase type IVA, member 1Blood-1.540.036
276RNF213ring finger protein 213Blood+1.530.044
277DDX3XDEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linkedBlood-1.530.002
278CHD9chromodomain helicase DNA binding protein 9Blood+1.530.027
279APLP2amyloid beta (A4) precursor-like protein 2Blood-1.520.003
280P2RX5purinergic receptor P2X, ligand-gated ion channel, 5Blood+1.520.034
281HIBADH3-hydroxyisobutyrate dehydrogenaseBlood-1.520.006
282REEP3receptor accessory protein 3Blood-1.510.020
283CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Blood+1.490.009
284CYBBcytochrome b-245, beta polypeptideBlood-1.490.004
285FGD4FYVE, RhoGEF and PH domain containing 4Blood-1.490.004
286HDChistidine decarboxylaseBlood+1.480.015
287PTPRKprotein tyrosine phosphatase, receptor type, KBlood+1.480.041
288CSPP1centrosome and spindle pole associated protein 1Blood+1.480.038
289SEPT7septin 7Blood+1.480.005
291STYXserine/threonine/tyrosine interacting proteinBlood-1.470.013
292DEDDdeath effector domain containingBlood-1.470.015
293ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)Blood+1.460.018
294LOC286272uncharacterized LOC286272Blood+1.460.025
295DUSP3dual specificity phosphatase 3Blood-1.460.010
296CCR3chemokine (C-C motif) receptor 3Blood+1.450.015
297AKAP12A kinase (PRKA) anchor protein 12Blood+1.450.048
298PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1BBlood+1.440.012
299SCAF11SR-related CTD-associated factor 11Blood+1.440.047
300SNORA21small nucleolar RNA, H/ACA box 21Blood+1.440.040
301DNAJC14DnaJ (Hsp40) homolog, subfamily C, member 14Blood-1.430.004
302EXOSC6exosome component 6Blood-1.430.013
303PRIM2primase, DNA, polypeptide 2 (58kDa)Blood-1.420.016
305SYNRGsynergin, gammaBlood-1.420.038
306SGOL2shugoshin-like 2 (S. pombe)Blood+1.410.040
307IL7interleukin 7Blood+1.410.036
308CRKLv-crk avian sarcoma virus CT10 oncogene homolog-likeBlood-1.400.018
309TP53tumor protein p53Blood-1.400.010
310ALKBH5alkB, alkylation repair homolog 5 (E. coli)Blood-1.390.026
311RTN3reticulon 3Blood-1.380.020
312CELF2CUGBP, Elav-like family member 2Blood-1.380.037
313UBE2Mubiquitin-conjugating enzyme E2MBlood-1.360.039
314MLLT10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10Blood+1.360.048
315GLUD1glutamate dehydrogenase 1Blood-1.350.008
317CAMPcathelicidin antimicrobial peptideBlood+1.350.045
318LRRC41leucine rich repeat containing 41Blood-1.350.046
319MFAP3microfibrillar-associated protein 3Blood-1.340.043
320ASMTL-AS1ASMTL antisense RNA 1Blood+1.340.012
321SPG7spastic paraplegia 7 (pure and complicated autosomal recessive)Blood+1.330.015
322COPG1coatomer protein complex, subunit gamma 1Blood-1.320.011
323EPG5ectopic P-granules autophagy protein 5 homolog (C. elegans)Blood+1.310.028
324CLINT1clathrin interactor 1Blood+1.300.042
325CBFBcore-binding factor, beta subunitBlood-1.300.041
326SAFBscaffold attachment factor BBlood-1.290.029
327GPR155G protein-coupled receptor 155Blood+1.280.049
328LIX1LLix1 homolog (mouse)-likeBlood-1.280.050
329GGNBP2gametogenetin binding protein 2Blood+1.280.045
330PKN2protein kinase N2Blood-1.250.030
331NONOnon-POU domain containing, octamer-bindingBlood-1.250.045
332SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Blood-1.240.033

Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

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Pathways for genes affiliated with Multiple Sclerosis

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Pathways related to Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL12B, IFNB1
210.2IL12B, IFNB1
Show member pathways
10.0CIITA, IL17A, IL12B, C3
410.0CIITA, IFNB1, IL12B, C3
Show member pathways

Compounds for genes affiliated with Multiple Sclerosis

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Compounds related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1compstatin control peptide6010.5C3, C5AR1
2ndt 95137276010.5C3, C5AR1
3compstatin6010.5C3, C5AR1
4polyinosinic-polycytidylic acid4410.5IL12B, IFNB1, CIITA
5peptidoglycan44 2911.5IL12B, IFNB1, CIITA
6edss4410.5IFNB1, MBP
7ccl444 2911.5IL12B, IL17A, IFNB1
8glatiramer acetate44 1211.4MBP, IFNB1, CIITA
9mezerein4410.4IFNB1, MBP
104-aminopyridine44 2911.4MBP, GABBR1
11sodium dodecylsulfate4410.3MBP, IL12B, CIITA
12pmsf4410.3MBP, C5AR1
13mannose4410.3C3, IL17A, CIITA
14imiquimod44 60 29 1213.3IFNB1, IL12B
15sb 20358044 6011.2IFNB1, IL17A, IL12B, C5AR1
16pd 98,0594410.2C5AR1, IL12B, IL17A, IFNB1
17endotoxin4410.2C5AR1, IL12B, IL17A, IFNB1, CIITA
18rantes4410.2CIITA, IFNB1, IL17A, IL12B, C5AR1
19pge24410.2CIITA, IFNB1, IL17A, IL12B, C5AR1
20thymidine44 2511.1CIITA, IFNB1, IL17A, MBP
21phosphatidylinositol4410.1CIITA, IL17A, IL12B, C3, C5AR1
22cycloheximide4410.1CIITA, IFNB1, IL12B, C5AR1, MBP
23creatinine4410.1IFNB1, IL17A, C3, C5AR1, MBP
24prostaglandin4410.0C5AR1, IL17A, IFNB1
25methotrexate50 44 1212.0MBP, IL17A, IFNB1
26aspartate4410.0IFNB1, C5AR1, GABBR1, MBP
27heparin44 29 25 1212.9MBP, C5AR1, C3, IFNB1
28cysteine449.9MBP, GABBR1, C5AR1, C3, IFNB1, CIITA
29lipid449.9CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
30glucose449.8CIITA, IFNB1, C3, GABBR1, TALDO1
31tyrosine449.7CIITA, PVRL2, IFNB1, IL17A, C5AR1, GABBR1
32phosphatidylserine44 29 1211.7MBP, TALDO1, C5AR1

GO Terms for genes affiliated with Multiple Sclerosis

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Biological processes related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to exogenous dsRNAGO:07136010.3IFNB1, CIITA
2positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.3IL12B, PVRL2
3positive regulation of osteoclast differentiationGO:04567210.3IL12B, IL17A
4natural killer cell activation involved in immune responseGO:00232310.1IFNB1, IL12B
5inflammatory responseGO:0069549.9CIITA, IL17A, C3, C5AR1
6natural killer cell activationGO:0301019.9IL12B, IFNB1
7immune responseGO:0069559.9C5AR1, CIITA, IL17A, C3, MBP

Molecular functions related to Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.1IL12B, IL17A, IFNB1

Products for genes affiliated with Multiple Sclerosis

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  • Antibodies
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Sources for Multiple Sclerosis

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27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet