MS
MCID: MLT020
MIFTS: 85

Multiple Sclerosis (MS) malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Multiple Sclerosis

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MedlinePlus:33 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards based summary: Multiple Sclerosis, also known as MS, is related to relapsing-remitting multiple sclerosis and optic neuritis. An important gene associated with Multiple Sclerosis is IL17A (interleukin 17A), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The drugs cyclophosphamide and hydroxocobalamin and the compounds compstatin control peptide and ndt 9513727 have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Genetics Home Reference:21 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

NIH Rare Diseases:42 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerveÔÇÖs ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:43 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Wikipedia:65 Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an... more...

Descriptions from OMIM:46 126200,612594,612595,612596,614810

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis

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Multiple Sclerosis, Aliases & Descriptions:

Name: Multiple Sclerosis 30 8 19 42 20 21 43 10 44 33 62
Ms 19 42 21
Generalized Multiple Sclerosis 8 62
 
Sclerosis, Disseminated 62
Disseminated Sclerosis 21
Insular Sclerosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:2377
MeSH34 D009103
ICD9CM27 340
NCIt39 C3243
ICD1025 G35

Related Diseases for Multiple Sclerosis

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Diseases in the Multiple Sclerosis family:

Primary Progressive Multiple Sclerosis Multiple Sclerosis 4
Multiple Sclerosis 3 Multiple Sclerosis 1
Multiple Sclerosis 2 Multiple Sclerosis 5

Diseases related to Multiple Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 582)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing-remitting multiple sclerosis32.6MBP, IFNB1
2optic neuritis32.0MBP, IFNB1
3neuromyelitis optica32.0IFNB1, MBP
4neuritis32.0MBP, CIITA
5secondary progressive multiple sclerosis31.9MBP, IFNB1
6primary progressive multiple sclerosis31.8MBP, IFNB1
7myelitis31.6MBP
8tropical spastic paraparesis31.2MBP, IFNB1
9encephalitis31.2CIITA, IL17A, IL12B, C5AR1, MBP
10demyelinating disease31.2MBP, IL17A, IFNB1
11measles31.1CIITA, IFNB1, IL12B, MBP
12arthritis31.1CIITA, IL17A, C3, C5AR1, GABBR1
13chronic inflammatory demyelinating polyneuropathy31.1IFNB1
14systemic lupus erythematosus31.0CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
15rheumatoid arthritis30.9CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
16tetanus30.7MBP, GABBR1, CIITA
17leukemia30.7IFNB1, IL17A, IL12B, C5AR1, MBP
18lyme disease30.7CIITA, MBP
19type 1 diabetes mellitus30.7C3, IL12B, CIITA
20herpes simplex30.6PVRL2, IFNB1, IL12B
21psoriasis30.6CIITA, IL17A, IL12B
22hepatitis c30.5IL12B, IFNB1, CIITA
23ischemia30.4CIITA, IL17A, C5AR1, GABBR1
24atherosclerosis30.4CIITA, IL17A, IL12B, C3, C5AR1
25myocarditis30.3IFNB1, CIITA
26cholera30.3IFNB1, IL17A, C5AR1
27tuberculosis30.1CIITA, IFNB1, IL17A, IL12B, C3, C5AR1
28asthma30.1CIITA, IFNB1, IL17A, IL12B, C5AR1, MBP
29pediatric multiple sclerosis11.0
30spasticity10.9
31venous insufficiency10.9
32cerebritis10.8
33blindness10.7
34allergic encephalomyelitis10.7
35acute disseminated encephalomyelitis10.7
36retinitis10.7
37neuronitis10.6
38progressive multifocal leukoencephalopathy10.6
39neurologic diseases10.6
40trigeminal neuralgia10.6
41cerebral atrophy10.6
42endotheliitis10.6
43transverse myelitis10.5
44infectious mononucleosis10.5
45cervicitis10.5
46autonomic dysfunction10.5
47memory impairment10.5
48uveitis10.5
49tremor10.5
50lupus erythematosus10.5

Graphical network of the top 20 diseases related to Multiple Sclerosis:



Diseases related to multiple sclerosis

Symptoms for Multiple Sclerosis

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Clinical features from OMIM:

126200,612594,612595,612596,614810

Drugs & Therapeutics for Multiple Sclerosis

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Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis

Search NIH Clinical Center for Multiple Sclerosis

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple Sclerosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple Sclerosis:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis

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Genetic tests related to Multiple Sclerosis:

id Genetic test Affiliating Genes
1 Multiple Sclerosis20

Anatomical Context for Multiple Sclerosis

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MalaCards organs/tissues related to Multiple Sclerosis:

32
T cells, Brain, Spinal cord, Bone, Testes, B cells, Monocytes, Endothelial, Bone marrow, Thyroid, Myeloid, Pituitary, Cortex, Nk cells, Eye, Neutrophil, Liver, Skin, Thymus, Cerebellum, Heart, Pineal, Whole blood, Lymph node, Lung, Ovary, Fetal brain, Thalamus, Hypothalamus, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis or affiliated genes

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MGI Mouse Phenotypes related to Multiple Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3CIITA, PADI2, IFNB1, IL17A, IL12B, C3
2MP:00053879.3CIITA, PADI2, IFNB1, IL17A, IL12B, C3
3MP:00053899.3MBP, PVRL2, C3, C5AR1, GABBR1, TALDO1
4MP:00053768.9GABBR1, TALDO1, CIITA, IFNB1, IL17A, IL12B

Publications for Multiple Sclerosis

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Articles related to Multiple Sclerosis:

(show top 50)    (show all 4890)
idTitleAuthorsYear
1
Multiple sclerosis and oligodendroglioma: an exceptional association. (25180114)
2014
2
Modelling the natural history of primary progressive multiple sclerosis. (24828900)
2014
3
Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis. (24312102)
2013
4
IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. (23726764)
2013
5
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency in people with multiple sclerosis: a summary of a Cochrane systematic review. (23781006)
2013
6
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
2013
7
Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations. (23602715)
2013
8
Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). (23747002)
2013
9
Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing-remitting multiple sclerosis patients. (23425504)
2013
10
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. (23472185)
2013
11
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. (23910387)
2013
12
Methodological issues with the risk of relapse study in patients with multiple sclerosis after yellow fever vaccination. (22232361)
2012
13
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
14
Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients. (22608171)
2012
15
Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains. (21737148)
2011
16
Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis. (20051521)
2010
17
Cerebellar information processing in relapsing-remitting multiple sclerosis (RRMS). (20714060)
2010
18
Magnetic resonance imaging at first episode in pediatric multiple sclerosis retrospective evaluation according to KIDMUS and lesion dissemination in space criteria. (19682809)
2010
19
Chronic cerebrospinal venous insufficiency and multiple sclerosis. (20373339)
2010
20
Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. (20309394)
2010
21
Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: is it a susceptibility gene? (20483145)
2010
22
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. (19631393)
2009
23
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis. (19039022)
2009
24
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (19525953)
2009
25
Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. (19251277)
2009
26
In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. (17911184)
2008
27
Determinants of cerebral atrophy rate at the time of diagnosis of multiple sclerosis. (17296834)
2007
28
Cytokine changes during interferon-beta therapy in multiple sclerosis: correlations with interferon dose and MRI response. (17328965)
2007
29
Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosis. (17273808)
2007
30
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
31
Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis. (16899302)
2006
32
Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. (16400315)
2005
33
Charles Bonnet syndrome associated with a first attack of multiple sclerosis. (16365804)
2005
34
Analysis of IL4R haplotypes in predisposition to multiple sclerosis. (14712310)
2004
35
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope. (12965253)
2003
36
Experience with high-dose immunosuppressive therapy followed by transplantation of autologous stem hematopoietic cells in patients with multiple sclerosis]. (12181832)
2002
37
Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. (12445803)
2002
38
Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis. (11571703)
2001
39
Cytokine and IL-12 receptor mRNA discriminate between different clinical subtypes in multiple sclerosis. (11694330)
2001
40
Dynamics of the reactivity to MBP in multiple sclerosis. (10871786)
2000
41
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
42
Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis. (10027703)
1999
43
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. (10079101)
1999
44
Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. (9258768)
1997
45
Increase of interleukin-2 soluble receptors in multiple sclerosis: preliminary study in 26 patients]. (7826250)
1994
46
Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. (7504688)
1993
47
Intermittent interferonemia and interferon responses in multiple sclerosis. (1701372)
1991
48
Natural killer (NK) cells in chronic progressive multiple sclerosis patients treated with lymphoblastoid interferon. (3183034)
1988
49
Preliminary trial of poly ICLC in chronic progressive multiple sclerosis. (3960323)
1986
50
Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. (6607973)
1983

Variations for Multiple Sclerosis

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Expression for genes affiliated with Multiple Sclerosis

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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis

Search GEO for disease gene expression data for Multiple Sclerosis.

Pathways for genes affiliated with Multiple Sclerosis

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Pathways related to Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL12B, IFNB1
210.2IFNB1, IL12B
3
Show member pathways
10.0C3, CIITA, IL17A, IL12B
410.0C3, CIITA, IFNB1, IL12B
5
Show member pathways
9.8IFNB1, CIITA, PVRL2, IL12B, C3

Compounds for genes affiliated with Multiple Sclerosis

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Compounds related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1compstatin control peptide6110.5C5AR1, C3
2ndt 95137276110.5C3, C5AR1
3compstatin6110.5C3, C5AR1
4polyinosinic-polycytidylic acid4410.5IFNB1, IL12B, CIITA
5peptidoglycan44 2811.5IFNB1, CIITA, IL12B
6edss4410.5MBP, IFNB1
7ccl444 2811.5IL17A, IFNB1, IL12B
8glatiramer acetate44 1111.4MBP, IFNB1, CIITA
9mezerein4410.4MBP, IFNB1
104-aminopyridine44 2811.4MBP, GABBR1
11sodium dodecylsulfate4410.3MBP, CIITA, IL12B
12pmsf4410.3C5AR1, MBP
13mannose4410.3C3, IL17A, CIITA
14imiquimod44 61 28 1113.3IL12B, IFNB1
15sb 20358044 6111.2IFNB1, IL17A, IL12B, C5AR1
16pd 98,0594410.2C5AR1, IFNB1, IL17A, IL12B
17endotoxin4410.2CIITA, IFNB1, IL17A, IL12B, C5AR1
18rantes4410.2C5AR1, IL17A, IFNB1, CIITA, IL12B
19pge24410.2CIITA, IL17A, IL12B, IFNB1, C5AR1
20thymidine44 2411.1IL17A, IFNB1, CIITA, MBP
21phosphatidylinositol4410.1C5AR1, C3, IL12B, IL17A, CIITA
22cycloheximide4410.1IL12B, CIITA, IFNB1, MBP, C5AR1
23creatinine4410.1IFNB1, IL17A, C3, C5AR1, MBP
24prostaglandin4410.0C5AR1, IL17A, IFNB1
25methotrexate50 44 1112.0IFNB1, MBP, IL17A
26aspartate4410.0C5AR1, GABBR1, MBP, IFNB1
27heparin44 28 24 1112.9IFNB1, C3, C5AR1, MBP
28cysteine449.9GABBR1, C3, IFNB1, CIITA, MBP, C5AR1
29lipid449.9C3, MBP, IL12B, IL17A, IFNB1, CIITA
30glucose449.8TALDO1, GABBR1, IFNB1, C3, CIITA
31tyrosine449.7C5AR1, IL17A, MBP, CD6, IFNB1, PVRL2
32phosphatidylserine44 28 1111.7TALDO1, C5AR1, MBP

GO Terms for genes affiliated with Multiple Sclerosis

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Biological processes related to Multiple Sclerosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to exogenous dsRNAGO:07136010.3IFNB1, CIITA
2positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.3IL12B, PVRL2
3positive regulation of osteoclast differentiationGO:04567210.3IL12B, IL17A
4natural killer cell activation involved in immune responseGO:00232310.1IFNB1, IL12B
5inflammatory responseGO:0069549.9CIITA, IL17A, C3, C5AR1
6natural killer cell activationGO:0301019.9IL12B, IFNB1
7immune responseGO:0069559.9C5AR1, CIITA, IL17A, C3, MBP

Molecular functions related to Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.1IL12B, IL17A, IFNB1

Products for genes affiliated with Multiple Sclerosis

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Sources for Multiple Sclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet