MCID: MLT121
MIFTS: 15

Multiple Sclerosis 1 malady

Summaries for Multiple Sclerosis 1

About this section
Sources:
46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Multiple Sclerosis 1 is related to myasthenia gravis and encephalomyelitis. An important gene associated with Multiple Sclerosis 1 is HLA-DRB1 (major histocompatibility complex, class II, DR beta 1), and among its related pathways are Epstein-Barr virus infection and PKC-Theta Pathway.

Description from OMIM:46 126200

Aliases & Classifications for Multiple Sclerosis 1

About this section
Sources:
46OMIM
See all sources

Aliases & Descriptions:

multiple sclerosis 1 46


Related Diseases for Multiple Sclerosis 1

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Multiple Sclerosis 1:



Diseases related to multiple sclerosis 1

Clinical Features for Multiple Sclerosis 1

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

126200

Drugs & Therapeutics for Multiple Sclerosis 1

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Multiple Sclerosis 1

Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis 1

Search NIH Clinical Center for Multiple Sclerosis 1

Search CenterWatch for Multiple Sclerosis 1

Genetic Tests for Multiple Sclerosis 1

About this section

Anatomical Context for Multiple Sclerosis 1

About this section

Animal Models for Multiple Sclerosis 1 or affiliated genes

About this section

Publications for Multiple Sclerosis 1

About this section

Genetic Variations for Multiple Sclerosis 1

About this section

Expression for genes affiliated with Multiple Sclerosis 1

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis 1

Search GEO for disease gene expression data for Multiple Sclerosis 1.

Pathways for genes affiliated with Multiple Sclerosis 1

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
See all sources

Pathways related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1HLA-DRB1, HLA-DQB1
2
Hide members
9.1HLA-DQB1, HLA-DRB1
39.1HLA-DRB1, HLA-DQB1
4
Hide members
9.1HLA-DQB1, HLA-DRB1
5
Hide members
9.1HLA-DRB1, HLA-DQB1
6
Hide members
9.1HLA-DRB1, HLA-DQB1
79.1HLA-DRB1, HLA-DQB1
8
Hide members
9.1HLA-DRB1, HLA-DQB1
9
Hide members
9.1HLA-DRB1, HLA-DQB1
10
Hide members
9.1HLA-DRB1, HLA-DQB1
11
Hide members
9.1HLA-DQB1, HLA-DRB1
129.1HLA-DRB1, HLA-DQB1
139.1HLA-DQB1, HLA-DRB1
14
Hide members
9.1HLA-DRB1, HLA-DQB1
159.1HLA-DRB1, HLA-DQB1
169.1HLA-DQB1, HLA-DRB1
179.1HLA-DRB1, HLA-DQB1
18
Hide members
9.1HLA-DRB1, HLA-DQB1
199.1HLA-DQB1, HLA-DRB1
20
Immune response ICOS pathway in T-helper cell
Hide members
9.1HLA-DRB1, HLA-DQB1
21
Hide members
9.1HLA-DRB1, HLA-DQB1
229.1HLA-DRB1, HLA-DQB1
23
Immune response NFAT in immune response
Hide members
9.1HLA-DQB1, HLA-DRB1
24
Hide members
9.1HLA-DRB1, HLA-DQB1
25
Immune response Antigen presentation by MHC class II
Hide members
9.1HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Multiple Sclerosis 1

About this section

GO Terms for genes affiliated with Multiple Sclerosis 1

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.3HLA-DRB1, HLA-DQB1
2clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DRB1, HLA-DQB1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.2HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:0306589.2HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.1HLA-DQB1, HLA-DRB1
6lysosomal membraneGO:0057659.1HLA-DRB1, HLA-DQB1
7trans-Golgi network membraneGO:0325889.0HLA-DRB1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.8HLA-DRB1, HLA-DQB1

Biological processes related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.3HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.3HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:0603339.2HLA-DRB1, HLA-DQB1
4T cell costimulationGO:0312959.2HLA-DRB1, HLA-DQB1
5T cell receptor signaling pathwayGO:0508529.1HLA-DQB1, HLA-DRB1
6immune responseGO:0069559.1HLA-DRB1, HLA-DQB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.0HLA-DRB1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:0192218.8HLA-DRB1, HLA-DQB1

Molecular functions related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Multiple Sclerosis 1

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis 1

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet