MCID: MLT121
MIFTS: 21

Multiple Sclerosis 1 malady

Genetic diseases, Neuronal diseases, Rare diseases categories
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Summaries for Multiple Sclerosis 1

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Sources:
47OMIM, 33MalaCards
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MalaCards: Multiple Sclerosis 1 is related to narcolepsy and juvenile rheumatoid arthritis. An important gene associated with Multiple Sclerosis 1 is HLA-DRB1 (major histocompatibility complex, class II, DR beta 1), and among its related pathways are HTLV-I infection and Interferon Signaling. The compounds glutamate and oligonucleotide have been mentioned in the context of this disorder.

Description from OMIM:47 126200

Aliases & Classifications for Multiple Sclerosis 1

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Sources:
47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

multiple sclerosis 1 47


Related Diseases for Multiple Sclerosis 1

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Multiple Sclerosis 1:



Diseases related to multiple sclerosis 1

Symptoms for Multiple Sclerosis 1

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Sources:
47OMIM
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Clinical features from OMIM:

126200

Drugs & Therapeutics for Multiple Sclerosis 1

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis 1

Search NIH Clinical Center for Multiple Sclerosis 1

Genetic Tests for Multiple Sclerosis 1

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Anatomical Context for Multiple Sclerosis 1

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Animal Models for Multiple Sclerosis 1 or affiliated genes

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Publications for Multiple Sclerosis 1

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Variations for Multiple Sclerosis 1

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Expression for genes affiliated with Multiple Sclerosis 1

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple Sclerosis 1

Search GEO for disease gene expression data for Multiple Sclerosis 1.

Pathways for genes affiliated with Multiple Sclerosis 1

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Sources:
50PathCards, 30KEGG, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1HLA-DRB1, HLA-DQB1
2
Show member pathways
9.1HLA-DQB1, HLA-DRB1
3
Show member pathways
9.1HLA-DQB1, HLA-DRB1
4
Show member pathways
9.1HLA-DQB1, HLA-DRB1
59.1HLA-DQB1, HLA-DRB1
6
Show member pathways
9.1HLA-DQB1, HLA-DRB1
7
Show member pathways
9.1HLA-DRB1, HLA-DQB1
8
Show member pathways
9.1HLA-DRB1, HLA-DQB1
9
Show member pathways
9.1HLA-DQB1, HLA-DRB1
10
Show member pathways
9.1HLA-DQB1, HLA-DRB1
11
Show member pathways
9.1HLA-DRB1, HLA-DQB1
129.1HLA-DQB1, HLA-DRB1
13
Show member pathways
9.1HLA-DRB1, HLA-DQB1
14
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1HLA-DQB1, HLA-DRB1
159.1HLA-DRB1, HLA-DQB1
16
Show member pathways
9.1HLA-DRB1, HLA-DQB1
179.1HLA-DRB1, HLA-DQB1
189.1HLA-DQB1, HLA-DRB1
19
Show member pathways
9.1HLA-DRB1, HLA-DQB1
209.1HLA-DRB1, HLA-DQB1
21
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.1HLA-DRB1, HLA-DQB1
229.1HLA-DRB1, HLA-DQB1
23
Show member pathways
9.1HLA-DRB1, HLA-DQB1
24
Show member pathways
9.1HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Multiple Sclerosis 1

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Sources:
45Novoseek
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Compounds related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate459.1HLA-DRB1, HLA-DQB1
2oligonucleotide458.8HLA-DRB1, HLA-DQB1

GO Terms for genes affiliated with Multiple Sclerosis 1

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Sources:
16Gene Ontology
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Cellular components related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.4HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DQB1, HLA-DRB1
4transport vesicle membraneGO:0306589.3HLA-DRB1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:0125079.2HLA-DRB1, HLA-DQB1
6trans-Golgi network membraneGO:0325889.2HLA-DQB1, HLA-DRB1
7endocytic vesicle membraneGO:0306669.1HLA-DRB1, HLA-DQB1
8membraneGO:0160209.1HLA-DRB1, HLA-DQB1
9lysosomal membraneGO:0057659.0HLA-DRB1, HLA-DQB1
10Golgi membraneGO:0001398.8HLA-DRB1, HLA-DQB1

Biological processes related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.3HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.3HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:0603339.2HLA-DRB1, HLA-DQB1
4T cell costimulationGO:0312959.2HLA-DRB1, HLA-DQB1
5T cell receptor signaling pathwayGO:0508529.1HLA-DQB1, HLA-DRB1
6immune responseGO:0069559.1HLA-DRB1, HLA-DQB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.0HLA-DRB1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:0192218.8HLA-DRB1, HLA-DQB1

Molecular functions related to Multiple Sclerosis 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Multiple Sclerosis 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple Sclerosis 1

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet