MCID: MLT077
MIFTS: 64

Multiple Sclerosis, Disease Progression, Modifier of malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Multiple Sclerosis, Disease Progression, Modifier of

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MedlinePlus:32 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards based summary: Multiple Sclerosis, Disease Progression, Modifier of, also known as multiple sclerosis, is related to narcolepsy and systemic lupus erythematosus, and has symptoms including urinary hesitancy, urinary incontinence and diplopia. An important gene associated with Multiple Sclerosis, Disease Progression, Modifier of is PDCD1 (programmed cell death 1), and among its related pathways are Allograft rejection and Epstein-Barr virus infection. The drugs azathioprine and baclofen and the compounds allergens and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

Disease Ontology:9 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Genetics Home Reference:21 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

NIH Rare Diseases:41 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:42 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Description from OMIM:45 126200

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis, Disease Progression, Modifier of

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Multiple Sclerosis, Disease Progression, Modifier of, Aliases & Descriptions:

Name: Multiple Sclerosis, Disease Progression, Modifier of 45 10 30
Multiple Sclerosis 45 30 9 19 41 20 21 42 11 43 32 60
Ms 19 41 21
Generalized Multiple Sclerosis 9
 
Disseminated Sclerosis 21
Multiple Sclerosis 1 45
Insular Sclerosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

OMIM45 126200
Disease Ontology9 DOID:2377
MeSH33 D009103
NCIt38 C3243
ICD9CM27 340
ICD1025 G35

Related Diseases for Multiple Sclerosis, Disease Progression, Modifier of

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Diseases related to Multiple Sclerosis, Disease Progression, Modifier of via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 551)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy30.8HLA-DRB1
2systemic lupus erythematosus30.3PDCD1, HLA-DRB1, HLA-DQB1
3pulmonary tuberculosis30.2HLA-DRB1, HLA-DQB1
4graves' disease30.1HLA-DRB1, HLA-DQB1
5rheumatoid arthritis30.1HLA-DQB1, HLA-DRB1, PDCD1
6hepatitis b30.1HLA-DRB1, HLA-DQB1
7schizophrenia30.0HLA-DRB1, HLA-DQB1
8primary biliary cirrhosis30.0PDCD1, HLA-DRB1
9galactosemia29.9PDCD1, HLA-DRB1
10autoimmune hepatitis29.7PDCD1, HLA-DRB1, HLA-DQB1
11tuberculosis29.6HLA-DQB1, HLA-DRB1
12relapsing-remitting multiple sclerosis11.3
13pediatric multiple sclerosis11.0
14optic neuritis10.9
15neuritis10.9
16neuromyelitis optica10.9
17venous insufficiency10.9
18spasticity10.9
19secondary progressive multiple sclerosis10.8
20cerebritis10.8
21primary progressive multiple sclerosis10.8
22blindness10.8
23allergic encephalomyelitis10.7
24acute disseminated encephalomyelitis10.7
25retinitis10.7
26neuronitis10.6
27progressive multifocal leukoencephalopathy10.6
28neurologic diseases10.6
29trigeminal neuralgia10.6
30myelitis10.6
31cerebral atrophy10.6
32endotheliitis10.6
33transverse myelitis10.5
34autonomic dysfunction10.5
35leukemia10.5
36cervicitis10.5
37uveitis10.5
38tremor10.5
39neurogenic bladder10.5
40encephalitis10.5
41lupus erythematosus10.5
42spastic paraparesis10.5
43arthritis10.4
44hematopoietic stem cell transplantation10.4
45restless legs syndrome10.4
46neuropathy10.4
47ophthalmoplegia10.4
48thyroiditis10.4
49tropical spastic paraparesis10.4
50meningitis10.4

Graphical network of the top 20 diseases related to Multiple Sclerosis, Disease Progression, Modifier of:



Diseases related to multiple sclerosis, disease progression, modifier of

Symptoms for Multiple Sclerosis, Disease Progression, Modifier of

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Symptoms by clinical synopsis from OMIM:

126200

Clinical features from OMIM:

126200

HPO human phenotypes related to Multiple Sclerosis, Disease Progression, Modifier of:

(show all 11)
id Description Frequency HPO Source Accession
1 urinary hesitancy HP:0000019
2 urinary incontinence HP:0000020
3 diplopia HP:0000651
4 emotional lability HP:0000712
5 depression HP:0000716
6 spasticity HP:0001257
7 muscle weakness HP:0001324
8 multifactorial inheritance HP:0001426
9 incoordination HP:0002311
10 paresthesia HP:0003401
11 cns demyelination HP:0007305

Drugs & Therapeutics for Multiple Sclerosis, Disease Progression, Modifier of

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Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis, Disease Progression, Modifier of

Search NIH Clinical Center for Multiple Sclerosis, Disease Progression, Modifier of

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Multiple Sclerosis, Disease Progression, Modifier of:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis, Disease Progression, Modifier of:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis, Disease Progression, Modifier of

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Genetic tests related to Multiple Sclerosis, Disease Progression, Modifier of:

id Genetic test Affiliating Genes
1 Multiple Sclerosis20

Anatomical Context for Multiple Sclerosis, Disease Progression, Modifier of

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MalaCards organs/tissues related to Multiple Sclerosis, Disease Progression, Modifier of:

31
Spinal cord, Brain, Bone, Testes, Bone marrow, Eye, Smooth muscle, Myeloid, T cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis, Disease Progression, Modifier of:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis, Disease Progression, Modifier of or affiliated genes

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Publications for Multiple Sclerosis, Disease Progression, Modifier of

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Variations for Multiple Sclerosis, Disease Progression, Modifier of

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Clinvar genetic disease variations for Multiple Sclerosis, Disease Progression, Modifier of:

6
id Gene Variation Type Significance SNP ID Assembly Location
1NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978

Expression for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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LifeMap Discovery
Genes differentially expressed in tissues of Multiple Sclerosis, Disease Progression, Modifier of patients vs. healthy controls: 30 (show all 113)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1GRIA2glutamate receptor, ionotropic, AMPA 2Amnion+5.600.000
2CNTN1contactin 1Amnion+4.720.005
3FABP7fatty acid binding protein 7, brainAmnion+4.600.003
4PMP2peripheral myelin protein 2Amnion+4.490.024
5CADM2cell adhesion molecule 2Amnion+4.330.010
6GPM6Aglycoprotein M6AAmnion+4.280.006
7SCG3secretogranin IIIAmnion+4.200.002
8NLGN4Xneuroligin 4, X-linkedAmnion+4.190.012
9PPP1R3Fprotein phosphatase 1, regulatory subunit 3FAmnion+4.180.000
10POU2F2POU class 2 homeobox 2Amnion+4.170.000
11GPM6Bglycoprotein M6BAmnion+4.010.039
12LHFPL3lipoma HMGIC fusion partner-like 3Amnion+4.010.012
13NKX2-2NK2 homeobox 2Amnion+3.950.009
14WSCD1WSC domain containing 1Amnion+3.900.003
15LPHN3latrophilin 3Amnion+3.830.014
16AASSaminoadipate-semialdehyde synthaseAmnion+3.790.001
17IZUMO1izumo sperm-egg fusion 1Amnion+3.790.001
18SH3GL2SH3-domain GRB2-like 2Amnion+3.790.014
19ORF1uncharacterized protein, clone pT-Adv JuaX22Amnion+3.710.007
20ZNF428zinc finger protein 428Amnion+3.700.002
21ZIC2Zic family member 2Amnion+3.670.043
22CD36CD36 molecule (thrombospondin receptor)Amnion+3.650.014
23ADSSL1adenylosuccinate synthase like 1Amnion+3.650.025
24CECR9cat eye syndrome chromosome region, candidate 9 (non-protein coding)Amnion+3.640.004
25NXPH1neurexophilin 1Amnion+3.640.041
26AUTS2autism susceptibility candidate 2Amnion+3.590.012
27ASCL1achaete-scute family bHLH transcription factor 1Amnion+3.590.014
28ZNF695zinc finger protein 695Spinal Cord-3.580.001
29MUSTN1musculoskeletal, embryonic nuclear protein 1Amnion+3.520.007
30MYT1myelin transcription factor 1Amnion+3.520.002
31DNAJC24DnaJ (Hsp40) homolog, subfamily C, member 24Amnion+3.510.013
32C2orf80chromosome 2 open reading frame 80Amnion+3.500.012
33CRMP1collapsin response mediator protein 1Amnion+3.490.004
34TRIM9tripartite motif containing 9Amnion+3.480.017
35AKNAAT-hook transcription factorAmnion+3.450.005
36PTENphosphatase and tensin homologAmnion+3.450.019
37CACUL1CDK2-associated, cullin domain 1Amnion+3.440.001
38CACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunitAmnion+3.430.006
39WBP2NLWBP2 N-terminal likeSpinal Cord-3.430.015
40ZFYVE16zinc finger, FYVE domain containing 16Amnion+3.380.032
41LRRTM2leucine rich repeat transmembrane neuronal 2Amnion+3.370.014
42FAM161Afamily with sequence similarity 161, member AAmnion+3.360.002
43LRRIQ1leucine-rich repeats and IQ motif containing 1Amnion+3.340.008
44PCDHB3protocadherin beta 3Amnion+3.340.003
45MSH3mutS homolog 3Amnion+3.330.026
46CHD9chromodomain helicase DNA binding protein 9Amnion+3.330.018
47BAHCC1BAH domain and coiled-coil containing 1Amnion+3.320.001
48EIF5Aeukaryotic translation initiation factor 5ABlood-3.300.000
49LOC645321uncharacterized LOC645321Amnion+3.300.000
50HUS1BHUS1 checkpoint homolog b (S. pombe)Amnion+3.300.004
51GFAPglial fibrillary acidic proteinAmnion+3.290.022
52DHFRdihydrofolate reductaseAmnion+3.290.027
53STMN2stathmin 2Amnion+3.290.047
54OLIG1oligodendrocyte transcription factor 1Amnion+3.280.050
55LINC00597long intergenic non-protein coding RNA 597Amnion+3.280.041
56DNAH9dynein, axonemal, heavy chain 9Amnion+3.260.006
57KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4Amnion+3.260.012
58GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseAmnion+3.260.011
59EPHX1epoxide hydrolase 1, microsomal (xenobiotic)Amnion+3.250.000
60GCC1GRIP and coiled-coil domain containing 1Amnion+3.240.012
61APBA2amyloid beta (A4) precursor protein-binding, family A, member 2Amnion+3.240.006
62OR5I1olfactory receptor, family 5, subfamily I, member 1Amnion+3.220.002
63PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Amnion+3.220.002
64ITSN1intersectin 1 (SH3 domain protein)Amnion+3.220.009
65LRTM2leucine-rich repeats and transmembrane domains 2Amnion+3.210.015
66HOXD9homeobox D9Amnion+3.200.001
67FAM118Afamily with sequence similarity 118, member ASpinal Cord-3.200.007
68NFASCneurofascinAmnion+3.200.029
69OLIG2oligodendrocyte lineage transcription factor 2Amnion+3.190.007
70LRRC16Bleucine rich repeat containing 16BAmnion+3.190.020
71CRATcarnitine O-acetyltransferaseAmnion+3.180.001
72UVSSAUV-stimulated scaffold protein AAmnion+3.180.006
73SOX1SRY (sex determining region Y)-box 1Amnion+3.180.013
74ERC2ELKS/RAB6-interacting/CAST family member 2Amnion+3.170.018
75GPRC5BG protein-coupled receptor, class C, group 5, member BAmnion+3.170.022
76NTRK2neurotrophic tyrosine kinase, receptor, type 2Amnion+3.160.018
77ZNF318zinc finger protein 318Amnion+3.160.003
78PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AAmnion+3.160.012
79TMEM37transmembrane protein 37Amnion+3.150.034
80GRIK2glutamate receptor, ionotropic, kainate 2Amnion+3.150.010
81SDSserine dehydrataseAmnion+3.150.002
82PDGFCplatelet derived growth factor CAmnion+3.150.011
83GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DAmnion+3.150.001
84FAM120AOSfamily with sequence similarity 120A opposite strandAmnion+3.140.001
85C14orf180chromosome 14 open reading frame 180Amnion+3.130.031
86CDC45cell division cycle 45Amnion+3.120.023
87DUSP26dual specificity phosphatase 26 (putative)Amnion+3.120.037
88ARCactivity-regulated cytoskeleton-associated proteinAmnion+3.110.031
89SYT7synaptotagmin VIIAmnion+3.100.049
90HINT3histidine triad nucleotide binding protein 3Blood-3.100.000
91ABCD2ATP-binding cassette, sub-family D (ALD), member 2Amnion+3.100.040
92TTBK2tau tubulin kinase 2Amnion+3.090.045
93LOC728543uncharacterized LOC728543Amnion+3.090.011
94ZNRF1zinc and ring finger 1, E3 ubiquitin protein ligaseAmnion+3.090.001
95TSPAN16tetraspanin 16Amnion+3.080.038
96LOC100128002uncharacterized LOC100128002Amnion+3.080.001
97ZIC3Zic family member 3Amnion+3.070.014
98SOX8SRY (sex determining region Y)-box 8Amnion+3.070.004
99CTNND2catenin (cadherin-associated protein), delta 2Amnion+3.060.006
100JSRP1junctional sarcoplasmic reticulum protein 1Amnion+3.060.001
101HSD17B6hydroxysteroid (17-beta) dehydrogenase 6Amnion+3.050.000
102TNFSF12tumor necrosis factor (ligand) superfamily, member 12Amnion+3.050.018
103PTGER3prostaglandin E receptor 3 (subtype EP3)Amnion+3.040.016
104RALGAPA1Ral GTPase activating protein, alpha subunit 1 (catalytic)Amnion+3.040.010
105TNNI2troponin I type 2 (skeletal, fast)Amnion+3.040.005
106RNF168ring finger protein 168, E3 ubiquitin protein ligaseAmnion+3.040.036
107CASRcalcium-sensing receptorAmnion+3.040.008
108LINC00304long intergenic non-protein coding RNA 304Amnion+3.040.001
109NCLNnicalinAmnion+3.030.013
110ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Amnion+3.030.005
111CCL13chemokine (C-C motif) ligand 13Amnion+3.010.000
112MRPL39mitochondrial ribosomal protein L39Amnion+3.010.035
113CAMK2Dcalcium/calmodulin-dependent protein kinase II deltaAmnion+3.000.019

Search GEO for disease gene expression data for Multiple Sclerosis, Disease Progression, Modifier of.

Pathways for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Pathways related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1HLA-DRB1, HLA-DQB1
29.1HLA-DRB1, HLA-DQB1
39.1HLA-DQB1, HLA-DRB1
4
Show member pathways
9.1HLA-DRB1, HLA-DQB1
5
Show member pathways
9.1HLA-DQB1, HLA-DRB1
69.1HLA-DRB1, HLA-DQB1
7
Show member pathways
9.1HLA-DRB1, HLA-DQB1
8
Show member pathways
9.1HLA-DRB1, HLA-DQB1
9
Show member pathways
9.1HLA-DQB1, HLA-DRB1
10
Show member pathways
9.1HLA-DRB1, HLA-DQB1
11
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.1HLA-DQB1, HLA-DRB1
129.1HLA-DQB1, HLA-DRB1
13
Show member pathways
9.1HLA-DRB1, HLA-DQB1
149.1HLA-DQB1, HLA-DRB1
15
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.1HLA-DQB1, HLA-DRB1
169.1HLA-DRB1, HLA-DQB1
179.1HLA-DRB1, HLA-DQB1
18
Show member pathways
9.1HLA-DRB1, HLA-DQB1
19
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1
208.5HLA-DQB1, HLA-DRB1, PDCD1
21
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1
22
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Sources:
43Novoseek
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Compounds related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1allergens438.7PDCD1, HLA-DRB1
2tyrosine438.5PDCD1, HLA-DRB1, HLA-DQB1

GO Terms for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Cellular components related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.4HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:00306699.3HLA-DQB1, HLA-DRB1
4transport vesicle membraneGO:00306589.3HLA-DRB1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:00125079.2HLA-DRB1, HLA-DQB1
6trans-Golgi network membraneGO:00325889.2HLA-DQB1, HLA-DRB1
7endocytic vesicle membraneGO:00306669.1HLA-DRB1, HLA-DQB1
8Golgi membraneGO:00001399.1HLA-DRB1, HLA-DQB1
9external side of plasma membraneGO:00098978.9PDCD1, HLA-DRB1
10lysosomal membraneGO:00057658.8HLA-DRB1, HLA-DQB1

Biological processes related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.3HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.2HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DQB1, HLA-DRB1
4T cell receptor signaling pathwayGO:00508529.1HLA-DRB1, HLA-DQB1
5immune responseGO:00069559.1HLA-DRB1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.0HLA-DRB1, HLA-DQB1
7cytokine-mediated signaling pathwayGO:00192218.8HLA-DRB1, HLA-DQB1
8T cell costimulationGO:00312958.7PDCD1, HLA-DRB1, HLA-DQB1

Molecular functions related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Sources for Multiple Sclerosis, Disease Progression, Modifier of

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet