MCID: MLT077
MIFTS: 57

Multiple Sclerosis, Disease Progression, Modifier of malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Multiple Sclerosis, Disease Progression, Modifier of

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MedlinePlus:34 Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath, the material that surrounds and protects your nerve cells. this damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. they can include visual disturbances muscle weakness trouble with coordination and balance sensations such as numbness, prickling, or "pins and needles" thinking and memory problems no one knows what causes ms. it may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. multiple sclerosis affects women more than men. it often begins between the ages of 20 and 40. usually, the disease is mild, but some people lose the ability to write, speak, or walk. there is no single test for ms. doctors use a medical history, physical exam, neurological exam, mri, and other tests to diagnose it. there is no cure for ms, but medicines may slow it down and help control symptoms. physical and occupational therapy may also help. nih: national institute of neurological disorders and stroke

MalaCards based summary: Multiple Sclerosis, Disease Progression, Modifier of, also known as multiple sclerosis, is related to systemic lupus erythematosus and narcolepsy, and has symptoms including urinary hesitancy, urinary incontinence and diplopia. An important gene associated with Multiple Sclerosis, Disease Progression, Modifier of is PDCD1 (programmed cell death 1), and among its related pathways are Allograft rejection and Epstein-Barr virus infection. The compounds allergens and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone.

Disease Ontology:10 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Genetics Home Reference:23 Multiple sclerosis is a condition characterized by areas of damage (lesions) on the brain and spinal cord. These lesions are associated with destruction of the covering that protects nerves and promotes the efficient transmission of nerve impulses (the myelin sheath) and damage to nerve cells. Multiple sclerosis is considered an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs, in this case tissues of the nervous system.

NIH Rare Diseases:43 Multiple sclerosis (ms) is a disorder that affects the central nervous system (cns), specifically the brain and spinal cord. a fatty tissue called myelin surrounds and protects the nerve fibers of the cns. myelin insulates the nerves and allows them to transmit electrical impulses from the brain to other parts of the body. in ms, myelin is lost in multiple areas, and sometimes the nerve fiber itself is damaged or broken. when myelin or the nerve fiber is destroyed or damaged, the nerve’s ability to conduct electrical impulses to and from the brain is disrupted; therefore, nerve signals cannot be transmitted. the disruption of the electrical impulses causes the symptoms associated with ms. last updated: 6/24/2013

NINDS:44 An unpredictable disease of the central nervous system, multiple sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.

Description from OMIM:47 126200

GeneReviews summary for ms

Aliases & Classifications for Multiple Sclerosis, Disease Progression, Modifier of

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Multiple Sclerosis, Disease Progression, Modifier of, Aliases & Descriptions:

Name: Multiple Sclerosis, Disease Progression, Modifier of 47 11 32
Multiple Sclerosis 47 32 10 21 43 22 23 44 12 45 34
Ms 21 43 23
Generalized Multiple Sclerosis 10
 
Disseminated Sclerosis 23
Multiple Sclerosis 1 47
Insular Sclerosis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

OMIM47 126200
Disease Ontology10 DOID:2377
MeSH35 D009103
NCIt40 C3243
ICD9CM29 340
ICD1027 G35

Related Diseases for Multiple Sclerosis, Disease Progression, Modifier of

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Diseases related to Multiple Sclerosis, Disease Progression, Modifier of via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 551)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.6PDCD1, HLA-DRB1, HLA-DQB1
2narcolepsy30.5HLA-DRB1
3rheumatoid arthritis30.5HLA-DQB1, HLA-DRB1, PDCD1
4graves' disease30.2HLA-DRB1, HLA-DQB1
5hepatitis b30.2HLA-DRB1, HLA-DQB1
6schizophrenia30.2HLA-DRB1, HLA-DQB1
7pulmonary tuberculosis30.2HLA-DRB1, HLA-DQB1
8primary biliary cirrhosis30.1PDCD1, HLA-DRB1
9galactosemia30.1PDCD1, HLA-DRB1
10autoimmune hepatitis30.1PDCD1, HLA-DRB1, HLA-DQB1
11tuberculosis29.8HLA-DQB1, HLA-DRB1
12relapsing-remitting multiple sclerosis11.3
13pediatric multiple sclerosis11.0
14optic neuritis10.9
15neuritis10.9
16neuromyelitis optica10.9
17venous insufficiency10.9
18spasticity10.9
19secondary progressive multiple sclerosis10.8
20cerebritis10.8
21primary progressive multiple sclerosis10.8
22blindness10.8
23allergic encephalomyelitis10.7
24acute disseminated encephalomyelitis10.7
25retinitis10.7
26neuronitis10.6
27progressive multifocal leukoencephalopathy10.6
28neurologic diseases10.6
29trigeminal neuralgia10.6
30myelitis10.6
31cerebral atrophy10.6
32endotheliitis10.6
33transverse myelitis10.5
34autonomic dysfunction10.5
35leukemia10.5
36cervicitis10.5
37uveitis10.5
38tremor10.5
39neurogenic bladder10.5
40encephalitis10.5
41lupus erythematosus10.5
42spastic paraparesis10.5
43arthritis10.4
44hematopoietic stem cell transplantation10.4
45restless legs syndrome10.4
46neuropathy10.4
47ophthalmoplegia10.4
48thyroiditis10.4
49tropical spastic paraparesis10.4
50meningitis10.4

Graphical network of the top 20 diseases related to Multiple Sclerosis, Disease Progression, Modifier of:



Diseases related to multiple sclerosis, disease progression, modifier of

Symptoms for Multiple Sclerosis, Disease Progression, Modifier of

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Symptoms by clinical synopsis from OMIM:

126200

Clinical features from OMIM:

126200

HPO human phenotypes related to Multiple Sclerosis, Disease Progression, Modifier of:

(show all 11)
id Description Frequency HPO Source Accession
1 urinary hesitancy HP:0000019
2 urinary incontinence HP:0000020
3 diplopia HP:0000651
4 emotional lability HP:0000712
5 depression HP:0000716
6 spasticity HP:0001257
7 muscle weakness HP:0001324
8 multifactorial inheritance HP:0001426
9 incoordination HP:0002311
10 paresthesia HP:0003401
11 cns demyelination HP:0007305

Drugs & Therapeutics for Multiple Sclerosis, Disease Progression, Modifier of

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Drug clinical trials:

Search ClinicalTrials for Multiple Sclerosis, Disease Progression, Modifier of

Search NIH Clinical Center for Multiple Sclerosis, Disease Progression, Modifier of

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Multiple Sclerosis, Disease Progression, Modifier of:
Autologous bone marrow-derived hematopoietic stem cells for the treatment of multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for multiple sclerosis
Bone marrow-derived mesenchymal stem cell transplantation for treatment of multiple sclerosis
Bone marrow-derived stromal cells for multiple sclerosis
Epiblast stem cell-derived oligodendrocyte progenitor cells for multiple sclerosis
FCRx, bioengineered hematopoietic stem cells for immunological tolerance
Hematopoietic stem cells for multiple sclerosis
MultiStem
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Peripheral blood-derived hematopoietic stem cells for treatment of multiple sclerosis
Placental-derived mesenchymal stem cells for treatment of multiple sclerosis
Stem cell-derived oligodendrocyte precursor cells for multiple sclerosis
Tcelna
Embryonic/Adult Cultured Cells Related to Multiple Sclerosis, Disease Progression, Modifier of:
Bone marrow-derived hematopoietic stem cells (family), PMID: 19378207
Bone marrow-derived mesenchymal stem cells, PMID: 22277374
Bone marrow-derived mesenchymal stem cells, PMIDs: 21366911, 22236384, 22277374
Bone marrow-derived mesenchymal stem cells (family)
Oligodendrocyte progenitor cells, PMID: 21946668
Facilitating cells, PMID: 17150368
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119
Umbilical cord-derived mesenchymal stem cells, PMID: 20682053
Peripheral blood-derived hematopoietic stem cells (family)
Placenta-derived mesenchymal stem cells, PMID: 22638856
Oligodendrocyte precursor cells, PMID: 19363151
Myelin-reactive T-cells, PMIDs: 18465664, 21563876, 19230777

Genetic Tests for Multiple Sclerosis, Disease Progression, Modifier of

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Genetic tests related to Multiple Sclerosis, Disease Progression, Modifier of:

id Genetic test Affiliating Genes
1 Multiple Sclerosis22

Anatomical Context for Multiple Sclerosis, Disease Progression, Modifier of

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MalaCards organs/tissues related to Multiple Sclerosis, Disease Progression, Modifier of:

33
Brain, Spinal cord, Bone, Testes, Bone marrow, T cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple Sclerosis, Disease Progression, Modifier of:
id TissueAnatomical CompartmentCell Relevance
1 BrainLateral VentricleAdult Oligodendrocyte Precursor Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
4 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
15 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
16 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
17 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate

Animal Models for Multiple Sclerosis, Disease Progression, Modifier of or affiliated genes

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Publications for Multiple Sclerosis, Disease Progression, Modifier of

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Variations for Multiple Sclerosis, Disease Progression, Modifier of

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Clinvar genetic disease variations for Multiple Sclerosis, Disease Progression, Modifier of:

7
id Gene Variation Type Significance SNP ID Assembly Location
1NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978

Expression for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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LifeMap Discovery
Genes differentially expressed in tissues of Multiple Sclerosis, Disease Progression, Modifier of patients vs. healthy controls: 32 (show all 332)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1GRIA2glutamate receptor, ionotropic, AMPA 2Amnion+5.600.000
2CNTN1contactin 1Amnion+4.720.005
3FABP7fatty acid binding protein 7, brainAmnion+4.600.003
4PMP2peripheral myelin protein 2Amnion+4.490.024
5CADM2cell adhesion molecule 2Amnion+4.330.010
6GPM6Aglycoprotein M6AAmnion+4.280.006
7SCG3secretogranin IIIAmnion+4.200.002
8NLGN4Xneuroligin 4, X-linkedAmnion+4.190.012
9PPP1R3Fprotein phosphatase 1, regulatory subunit 3FAmnion+4.180.000
10POU2F2POU class 2 homeobox 2Amnion+4.170.000
11GPM6Bglycoprotein M6BAmnion+4.010.039
12LHFPL3lipoma HMGIC fusion partner-like 3Amnion+4.010.012
13NKX2-2NK2 homeobox 2Amnion+3.950.009
14WSCD1WSC domain containing 1Amnion+3.900.003
15LPHN3latrophilin 3Amnion+3.830.014
16AASSaminoadipate-semialdehyde synthaseAmnion+3.790.001
17IZUMO1izumo sperm-egg fusion 1Amnion+3.790.001
18SH3GL2SH3-domain GRB2-like 2Amnion+3.790.014
19ORF1uncharacterized protein, clone pT-Adv JuaX22Amnion+3.710.007
20ZNF428zinc finger protein 428Amnion+3.700.002
21ZIC2Zic family member 2Amnion+3.670.043
22CD36CD36 molecule (thrombospondin receptor)Amnion+3.650.014
23ADSSL1adenylosuccinate synthase like 1Amnion+3.650.025
24CECR9cat eye syndrome chromosome region, candidate 9 (non-protein coding)Amnion+3.640.004
25NXPH1neurexophilin 1Amnion+3.640.041
26AUTS2autism susceptibility candidate 2Amnion+3.590.012
27ASCL1achaete-scute family bHLH transcription factor 1Amnion+3.590.014
28ZNF695zinc finger protein 695Spinal Cord-3.580.001
29MUSTN1musculoskeletal, embryonic nuclear protein 1Amnion+3.520.007
30MYT1myelin transcription factor 1Amnion+3.520.002
31DNAJC24DnaJ (Hsp40) homolog, subfamily C, member 24Amnion+3.510.013
32C2orf80chromosome 2 open reading frame 80Amnion+3.500.012
33CRMP1collapsin response mediator protein 1Amnion+3.490.004
34TRIM9tripartite motif containing 9Amnion+3.480.017
35AKNAAT-hook transcription factorAmnion+3.450.005
36PTENphosphatase and tensin homologAmnion+3.450.019
37CACUL1CDK2-associated, cullin domain 1Amnion+3.440.001
38CACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunitAmnion+3.430.006
39WBP2NLWBP2 N-terminal likeSpinal Cord-3.430.015
40ZFYVE16zinc finger, FYVE domain containing 16Amnion+3.380.032
41LRRTM2leucine rich repeat transmembrane neuronal 2Amnion+3.370.014
42FAM161Afamily with sequence similarity 161, member AAmnion+3.360.002
43LRRIQ1leucine-rich repeats and IQ motif containing 1Amnion+3.340.008
44PCDHB3protocadherin beta 3Amnion+3.340.003
45MSH3mutS homolog 3Amnion+3.330.026
46CHD9chromodomain helicase DNA binding protein 9Amnion+3.330.018
47BAHCC1BAH domain and coiled-coil containing 1Amnion+3.320.001
48EIF5Aeukaryotic translation initiation factor 5ABlood-3.300.000
49LOC645321uncharacterized LOC645321Amnion+3.300.000
50HUS1BHUS1 checkpoint homolog b (S. pombe)Amnion+3.300.004
51GFAPglial fibrillary acidic proteinAmnion+3.290.022
52DHFRdihydrofolate reductaseAmnion+3.290.027
53STMN2stathmin 2Amnion+3.290.047
54OLIG1oligodendrocyte transcription factor 1Amnion+3.280.050
55LINC00597long intergenic non-protein coding RNA 597Amnion+3.280.041
56DNAH9dynein, axonemal, heavy chain 9Amnion+3.260.006
57KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4Amnion+3.260.012
58GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseAmnion+3.260.011
59EPHX1epoxide hydrolase 1, microsomal (xenobiotic)Amnion+3.250.000
60GCC1GRIP and coiled-coil domain containing 1Amnion+3.240.012
61APBA2amyloid beta (A4) precursor protein-binding, family A, member 2Amnion+3.240.006
62OR5I1olfactory receptor, family 5, subfamily I, member 1Amnion+3.220.002
63PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Amnion+3.220.002
64ITSN1intersectin 1 (SH3 domain protein)Amnion+3.220.009
65LRTM2leucine-rich repeats and transmembrane domains 2Amnion+3.210.015
66HOXD9homeobox D9Amnion+3.200.001
67FAM118Afamily with sequence similarity 118, member ASpinal Cord-3.200.007
68NFASCneurofascinAmnion+3.200.029
69OLIG2oligodendrocyte lineage transcription factor 2Amnion+3.190.007
70LRRC16Bleucine rich repeat containing 16BAmnion+3.190.020
71CRATcarnitine O-acetyltransferaseAmnion+3.180.001
72UVSSAUV-stimulated scaffold protein AAmnion+3.180.006
73SOX1SRY (sex determining region Y)-box 1Amnion+3.180.013
74ERC2ELKS/RAB6-interacting/CAST family member 2Amnion+3.170.018
75GPRC5BG protein-coupled receptor, class C, group 5, member BAmnion+3.170.022
76NTRK2neurotrophic tyrosine kinase, receptor, type 2Amnion+3.160.018
77ZNF318zinc finger protein 318Amnion+3.160.003
78PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AAmnion+3.160.012
79TMEM37transmembrane protein 37Amnion+3.150.034
80GRIK2glutamate receptor, ionotropic, kainate 2Amnion+3.150.010
81SDSserine dehydrataseAmnion+3.150.002
82PDGFCplatelet derived growth factor CAmnion+3.150.011
83GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DAmnion+3.150.001
84FAM120AOSfamily with sequence similarity 120A opposite strandAmnion+3.140.001
85C14orf180chromosome 14 open reading frame 180Amnion+3.130.031
86CDC45cell division cycle 45Amnion+3.120.023
87DUSP26dual specificity phosphatase 26 (putative)Amnion+3.120.037
88ARCactivity-regulated cytoskeleton-associated proteinAmnion+3.110.031
89SYT7synaptotagmin VIIAmnion+3.100.049
90HINT3histidine triad nucleotide binding protein 3Blood-3.100.000
91ABCD2ATP-binding cassette, sub-family D (ALD), member 2Amnion+3.100.040
92TTBK2tau tubulin kinase 2Amnion+3.090.045
93LOC728543uncharacterized LOC728543Amnion+3.090.011
94ZNRF1zinc and ring finger 1, E3 ubiquitin protein ligaseAmnion+3.090.001
95TSPAN16tetraspanin 16Amnion+3.080.038
96LOC100128002uncharacterized LOC100128002Amnion+3.080.001
97ZIC3Zic family member 3Amnion+3.070.014
98SOX8SRY (sex determining region Y)-box 8Amnion+3.070.004
99CTNND2catenin (cadherin-associated protein), delta 2Amnion+3.060.006
100JSRP1junctional sarcoplasmic reticulum protein 1Amnion+3.060.001
101HSD17B6hydroxysteroid (17-beta) dehydrogenase 6Amnion+3.050.000
102TNFSF12tumor necrosis factor (ligand) superfamily, member 12Amnion+3.050.018
103PTGER3prostaglandin E receptor 3 (subtype EP3)Amnion+3.040.016
104RALGAPA1Ral GTPase activating protein, alpha subunit 1 (catalytic)Amnion+3.040.010
105TNNI2troponin I type 2 (skeletal, fast)Amnion+3.040.005
106RNF168ring finger protein 168, E3 ubiquitin protein ligaseAmnion+3.040.036
107CASRcalcium-sensing receptorAmnion+3.040.008
108LINC00304long intergenic non-protein coding RNA 304Amnion+3.040.001
109NCLNnicalinAmnion+3.030.013
110ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Amnion+3.030.005
111CCL13chemokine (C-C motif) ligand 13Amnion+3.010.000
112MRPL39mitochondrial ribosomal protein L39Amnion+3.010.035
113CAMK2Dcalcium/calmodulin-dependent protein kinase II deltaAmnion+3.000.019
114LOC283484uncharacterized LOC283484Amnion+3.000.006
115LCTlactaseAmnion+2.990.014
116KCNA2potassium voltage-gated channel, shaker-related subfamily, member 2Amnion+2.990.040
117PURGpurine-rich element binding protein GAmnion+2.990.015
118NRP2neuropilin 2Amnion+2.990.038
119GAL3ST1galactose-3-O-sulfotransferase 1Amnion+2.980.010
120REXO1REX1, RNA exonuclease 1 homolog (S. cerevisiae)Amnion+2.980.024
121FAM19A5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5Amnion+2.980.005
122FGFR2fibroblast growth factor receptor 2Amnion+2.970.001
123ABLIM2actin binding LIM protein family, member 2Amnion+2.970.009
124C9orf156chromosome 9 open reading frame 156Amnion+2.960.000
125PSMD5proteasome (prosome, macropain) 26S subunit, non-ATPase, 5Amnion+2.960.013
126PTGIRprostaglandin I2 (prostacyclin) receptor (IP)Amnion+2.950.003
127AP5S1adaptor-related protein complex 5, sigma 1 subunitAmnion+2.950.044
128BRINP3bone morphogenetic protein/retinoic acid inducible neural-specific 3Amnion+2.950.038
129DOK6docking protein 6Spinal Cord-2.940.016
130RASSF4Ras association (RalGDS/AF-6) domain family member 4Amnion+2.940.012
131PSMG4proteasome (prosome, macropain) assembly chaperone 4Amnion+2.930.002
132GPR75G protein-coupled receptor 75Amnion+2.930.008
133RNF152ring finger protein 152Amnion+2.920.012
134CLIP3CAP-GLY domain containing linker protein 3Amnion+2.920.010
135POU4F1POU class 4 homeobox 1Amnion+2.920.015
136LOC100287221uncharacterized LOC100287221Amnion+2.920.001
137MYH11myosin, heavy chain 11, smooth muscleAmnion+2.920.011
138KRTAP1-3keratin associated protein 1-3Spinal Cord-2.880.007
139RNF152ring finger protein 152Spinal Cord-2.800.026
140MTUS2microtubule associated tumor suppressor candidate 2Spinal Cord-2.780.002
141LOC441052uncharacterized LOC441052Spinal Cord-2.760.003
142FAM161Afamily with sequence similarity 161, member ASpinal Cord-2.760.020
143AGBL3ATP/GTP binding protein-like 3Spinal Cord-2.750.037
144LOC284926uncharacterized LOC284926Spinal Cord-2.740.011
145PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)Spinal Cord-2.730.042
146HECTD4HECT domain containing E3 ubiquitin protein ligase 4Spinal Cord-2.730.010
147ANKRD7ankyrin repeat domain 7Spinal Cord-2.720.012
148ZNF214zinc finger protein 214Spinal Cord-2.700.011
149AURKCaurora kinase CSpinal Cord-2.680.007
150ZNF253zinc finger protein 253Spinal Cord-2.670.034
151NRXN1neurexin 1Spinal Cord-2.660.014
152ZDHHC21zinc finger, DHHC-type containing 21Spinal Cord-2.640.035
153GCSAMLgerminal center-associated, signaling and motility-likeSpinal Cord-2.640.015
154AAK1AP2 associated kinase 1Spinal Cord-2.630.023
155KRT6Akeratin 6ASpinal Cord-2.620.004
156SUGT1P3SUGT1 pseudogene 3Spinal Cord-2.600.002
157USP45ubiquitin specific peptidase 45Spinal Cord-2.590.043
158FAM84Afamily with sequence similarity 84, member ASpinal Cord-2.570.011
159IL18R1interleukin 18 receptor 1Spinal Cord-2.570.044
160CDH26cadherin 26Spinal Cord-2.570.025
161SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1Spinal Cord-2.570.025
162IL31RAinterleukin 31 receptor ASpinal Cord-2.570.027
163AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1Spinal Cord-2.550.037
164ODF2outer dense fiber of sperm tails 2Spinal Cord-2.530.035
165CCDC120coiled-coil domain containing 120Spinal Cord-2.520.024
166C5orf58chromosome 5 open reading frame 58Spinal Cord-2.500.036
167FAM53Bfamily with sequence similarity 53, member BSpinal Cord-2.500.012
168LTN1listerin E3 ubiquitin protein ligase 1Spinal Cord-2.490.022
169UNC13Cunc-13 homolog C (C. elegans)Spinal Cord-2.490.030
170DMRT1doublesex and mab-3 related transcription factor 1Spinal Cord-2.490.009
171KLF5Kruppel-like factor 5 (intestinal)Spinal Cord-2.480.017
172HELLShelicase, lymphoid-specificSpinal Cord-2.470.043
173ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12Spinal Cord-2.470.004
174THOC5THO complex 5Spinal Cord-2.470.046
175GPR17G protein-coupled receptor 17Spinal Cord-2.450.031
176LOC100294362uncharacterized LOC100294362Spinal Cord-2.440.047
177TMC5transmembrane channel-like 5Spinal Cord-2.430.020
178SPTAN1spectrin, alpha, non-erythrocytic 1Spinal Cord-2.430.007
179CNPY2canopy FGF signaling regulator 2Spinal Cord-2.430.047
180AFF3AF4/FMR2 family, member 3Spinal Cord-2.430.017
181MBTD1mbt domain containing 1Spinal Cord-2.400.046
182RPS15Aribosomal protein S15aSpinal Cord-2.400.028
183DZANK1double zinc ribbon and ankyrin repeat domains 1Spinal Cord-2.390.033
184ONECUT2one cut homeobox 2Spinal Cord-2.390.015
185ZNF169zinc finger protein 169Spinal Cord-2.380.019
186WDR19WD repeat domain 19Spinal Cord-2.380.028
187COQ10Bcoenzyme Q10 homolog B (S. cerevisiae)Spinal Cord-2.380.029
188ZDHHC24zinc finger, DHHC-type containing 24Spinal Cord-2.370.008
189C17orf98chromosome 17 open reading frame 98Spinal Cord-2.350.028
190CSMD1CUB and Sushi multiple domains 1Spinal Cord-2.350.044
191DOCK5dedicator of cytokinesis 5Spinal Cord-2.350.014
192HIST1H3Fhistone cluster 1, H3fSpinal Cord-2.340.040
193LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood-2.340.000
194CCDC67coiled-coil domain containing 67Spinal Cord-2.340.047
195LOC284578uncharacterized LOC284578Spinal Cord-2.330.037
196LOC286058uncharacterized LOC286058Spinal Cord-2.330.027
197ARF6ADP-ribosylation factor 6Blood-2.290.000
198DNAH5dynein, axonemal, heavy chain 5Spinal Cord-2.290.013
199M1APmeiosis 1 associated proteinSpinal Cord-2.280.019
200HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupledSpinal Cord-2.260.049
201LYRM7LYR motif containing 7Spinal Cord-2.260.022
202NAP1L4nucleosome assembly protein 1-like 4Spinal Cord-2.260.017
203TMEM52transmembrane protein 52Spinal Cord-2.260.027
204LOC100287387uncharacterized LOC100287387Spinal Cord-2.230.036
205C10orf95chromosome 10 open reading frame 95Spinal Cord-2.230.022
206ALYREFAly/REF export factorBlood-2.230.000
207HN1Lhematological and neurological expressed 1-likeSpinal Cord-2.220.028
208CCDC17coiled-coil domain containing 17Spinal Cord-2.220.037
209LINC00474long intergenic non-protein coding RNA 474Spinal Cord-2.220.033
210AP3B2adaptor-related protein complex 3, beta 2 subunitSpinal Cord-2.210.017
211HOXD4homeobox D4Spinal Cord-2.200.012
212FAM78Bfamily with sequence similarity 78, member BSpinal Cord-2.190.034
213SMR3Asubmaxillary gland androgen regulated protein 3ASpinal Cord-2.170.032
214SNX20sorting nexin 20Blood-2.170.000
215TBX3T-box 3Spinal Cord-2.170.016
216MMP17matrix metallopeptidase 17 (membrane-inserted)Spinal Cord-2.140.011
217SSBP1single-stranded DNA binding protein 1, mitochondrialSpinal Cord-2.130.048
218CYTH2cytohesin 2Spinal Cord-2.120.024
219TULP4tubby like protein 4Spinal Cord-2.120.041
220GM2AGM2 ganglioside activatorBlood-2.110.001
221LOC283674uncharacterized LOC283674Spinal Cord-2.100.039
222MSH6mutS homolog 6Spinal Cord-2.090.035
223CASP2caspase 2, apoptosis-related cysteine peptidaseBlood-2.070.000
224TMEM88transmembrane protein 88Spinal Cord-2.060.021
225FCARFc fragment of IgA, receptor forBlood-2.050.000
226TTC26tetratricopeptide repeat domain 26Spinal Cord-2.040.020
227CLNKcytokine-dependent hematopoietic cell linkerSpinal Cord-2.030.048
228SLC2A4solute carrier family 2 (facilitated glucose transporter), member 4Spinal Cord-2.020.044
229MOB3AMOB kinase activator 3ABlood-2.010.000
230CROCCciliary rootlet coiled-coil, rootletinSpinal Cord-2.010.029
231EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaBlood-1.970.000
232NAALADL2N-acetylated alpha-linked acidic dipeptidase-like 2Spinal Cord-1.960.044
233UBA6ubiquitin-like modifier activating enzyme 6Blood-1.960.010
234SNRNP40small nuclear ribonucleoprotein 40kDa (U5)Blood-1.960.000
235MASP2mannan-binding lectin serine peptidase 2Spinal Cord-1.960.017
236ZMIZ2zinc finger, MIZ-type containing 2Spinal Cord-1.950.038
237RGS14regulator of G-protein signaling 14Spinal Cord-1.940.038
238GLRA3glycine receptor, alpha 3Spinal Cord-1.940.041
239SLAMF9SLAM family member 9Spinal Cord-1.930.024
240KRT4keratin 4Spinal Cord-1.930.011
241C1orf174chromosome 1 open reading frame 174Blood-1.920.001
242MAT2Amethionine adenosyltransferase II, alphaBlood-1.920.000
243C22orf26chromosome 22 open reading frame 26Spinal Cord-1.910.043
244PKP4plakophilin 4Spinal Cord-1.890.027
245POLKpolymerase (DNA directed) kappaBlood-1.890.000
246VWA1von Willebrand factor A domain containing 1Spinal Cord-1.870.038
247CNKSR1connector enhancer of kinase suppressor of Ras 1Spinal Cord-1.840.032
248HIF3Ahypoxia inducible factor 3, alpha subunitSpinal Cord-1.820.042
249SLC25A37solute carrier family 25 (mitochondrial iron transporter), member 37Spinal Cord-1.810.050
250TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)Blood-1.800.000
251ELAVL3ELAV like neuron-specific RNA binding protein 3Spinal Cord-1.790.042
252KCNE3potassium voltage-gated channel, Isk-related family, member 3Blood-1.770.001
253PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alphaBlood-1.740.001
254MS4A6Amembrane-spanning 4-domains, subfamily A, member 6ABlood-1.740.004
255ARPC4actin related protein 2/3 complex, subunit 4, 20kDaBlood-1.730.000
256MDM4MDM4, p53 regulatorBlood-1.730.000
257C17orf103chromosome 17 open reading frame 103Spinal Cord-1.700.045
258PPP6R3protein phosphatase 6, regulatory subunit 3Blood-1.690.011
259LAMP1lysosomal-associated membrane protein 1Blood-1.690.007
260SERPINB9serpin peptidase inhibitor, clade B (ovalbumin), member 9Blood-1.680.000
261SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1Blood-1.670.002
262CLEC7AC-type lectin domain family 7, member ABlood-1.670.000
263PRF1perforin 1 (pore forming protein)Blood-1.670.023
264C21orf33chromosome 21 open reading frame 33Blood-1.650.001
265STAT2signal transducer and activator of transcription 2, 113kDaBlood-1.640.000
266STT3ASTT3A, subunit of the oligosaccharyltransferase complex (catalytic)Blood-1.610.000
267ADAM9ADAM metallopeptidase domain 9Blood-1.600.001
268ACTBactin, betaBlood-1.590.002
269ICAM1intercellular adhesion molecule 1Blood-1.570.011
270HLA-DOBmajor histocompatibility complex, class II, DO betaBlood+1.570.019
271NUPL1nucleoporin like 1Blood+1.560.021
272HIPK3homeodomain interacting protein kinase 3Blood-1.560.007
273USP1ubiquitin specific peptidase 1Blood+1.550.006
274SLFN5schlafen family member 5Blood+1.540.024
275PTP4A1protein tyrosine phosphatase type IVA, member 1Blood-1.540.036
276RNF213ring finger protein 213Blood+1.530.044
277DDX3XDEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linkedBlood-1.530.002
278CHD9chromodomain helicase DNA binding protein 9Blood+1.530.027
279APLP2amyloid beta (A4) precursor-like protein 2Blood-1.520.003
280P2RX5purinergic receptor P2X, ligand-gated ion channel, 5Blood+1.520.034
281HIBADH3-hydroxyisobutyrate dehydrogenaseBlood-1.520.006
282REEP3receptor accessory protein 3Blood-1.510.020
283CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Blood+1.490.009
284CYBBcytochrome b-245, beta polypeptideBlood-1.490.004
285FGD4FYVE, RhoGEF and PH domain containing 4Blood-1.490.004
286HDChistidine decarboxylaseBlood+1.480.015
287PTPRKprotein tyrosine phosphatase, receptor type, KBlood+1.480.041
288CSPP1centrosome and spindle pole associated protein 1Blood+1.480.038
2897-Sepseptin 7Blood+1.480.005
290B2Mbeta-2-microglobulinBlood+1.480.033
291STYXserine/threonine/tyrosine interacting proteinBlood-1.470.013
292DEDDdeath effector domain containingBlood-1.470.015
293ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)Blood+1.460.018
294LOC286272uncharacterized LOC286272Blood+1.460.025
295DUSP3dual specificity phosphatase 3Blood-1.460.010
296CCR3chemokine (C-C motif) receptor 3Blood+1.450.015
297AKAP12A kinase (PRKA) anchor protein 12Blood+1.450.048
298PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1BBlood+1.440.012
299SCAF11SR-related CTD-associated factor 11Blood+1.440.047
300SNORA21small nucleolar RNA, H/ACA box 21Blood+1.440.040
301DNAJC14DnaJ (Hsp40) homolog, subfamily C, member 14Blood-1.430.004
302EXOSC6exosome component 6Blood-1.430.013
303PRIM2primase, DNA, polypeptide 2 (58kDa)Blood-1.420.016
304KIAA1731KIAA1731Blood+1.420.036
305SYNRGsynergin, gammaBlood-1.420.038
306SGOL2shugoshin-like 2 (S. pombe)Blood+1.410.040
307IL7interleukin 7Blood+1.410.036
308CRKLv-crk avian sarcoma virus CT10 oncogene homolog-likeBlood-1.400.018
309TP53tumor protein p53Blood-1.400.010
310ALKBH5alkB, alkylation repair homolog 5 (E. coli)Blood-1.390.026
311RTN3reticulon 3Blood-1.380.020
312CELF2CUGBP, Elav-like family member 2Blood-1.380.037
313UBE2Mubiquitin-conjugating enzyme E2MBlood-1.360.039
314MLLT10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10Blood+1.360.048
315GLUD1glutamate dehydrogenase 1Blood-1.350.008
316CALRcalreticulinBlood+1.350.016
317CAMPcathelicidin antimicrobial peptideBlood+1.350.045
318LRRC41leucine rich repeat containing 41Blood-1.350.046
319MFAP3microfibrillar-associated protein 3Blood-1.340.043
320ASMTL-AS1ASMTL antisense RNA 1Blood+1.340.012
321SPG7spastic paraplegia 7 (pure and complicated autosomal recessive)Blood+1.330.015
322COPG1coatomer protein complex, subunit gamma 1Blood-1.320.011
323EPG5ectopic P-granules autophagy protein 5 homolog (C. elegans)Blood+1.310.028
324CLINT1clathrin interactor 1Blood+1.300.042
325CBFBcore-binding factor, beta subunitBlood-1.300.041
326SAFBscaffold attachment factor BBlood-1.290.029
327GPR155G protein-coupled receptor 155Blood+1.280.049
328LIX1LLix1 homolog (mouse)-likeBlood-1.280.050
329GGNBP2gametogenetin binding protein 2Blood+1.280.045
330PKN2protein kinase N2Blood-1.250.030
331NONOnon-POU domain containing, octamer-bindingBlood-1.250.045
332SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Blood-1.240.033


Search GEO for disease gene expression data for Multiple Sclerosis, Disease Progression, Modifier of.

Pathways for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

About this section

Pathways related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1HLA-DRB1, HLA-DQB1
29.1HLA-DRB1, HLA-DQB1
39.1HLA-DQB1, HLA-DRB1
4
Show member pathways
9.1HLA-DRB1, HLA-DQB1
5
Show member pathways
9.1HLA-DQB1, HLA-DRB1
69.1HLA-DRB1, HLA-DQB1
7
Show member pathways
9.1HLA-DRB1, HLA-DQB1
8
Show member pathways
9.1HLA-DRB1, HLA-DQB1
9
Show member pathways
9.1HLA-DQB1, HLA-DRB1
10
Show member pathways
9.1HLA-DRB1, HLA-DQB1
11
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.1HLA-DQB1, HLA-DRB1
129.1HLA-DQB1, HLA-DRB1
13
Show member pathways
9.1HLA-DRB1, HLA-DQB1
149.1HLA-DQB1, HLA-DRB1
15
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1HLA-DQB1, HLA-DRB1
169.1HLA-DRB1, HLA-DQB1
179.1HLA-DRB1, HLA-DQB1
18
Show member pathways
9.1HLA-DRB1, HLA-DQB1
19
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1
208.5HLA-DQB1, HLA-DRB1, PDCD1
21
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1
22
Show member pathways
8.5PDCD1, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Sources:
45Novoseek
See all sources

Compounds related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1allergens458.7PDCD1, HLA-DRB1
2tyrosine458.5PDCD1, HLA-DRB1, HLA-DQB1

GO Terms for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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Cellular components related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.4HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:00306699.3HLA-DQB1, HLA-DRB1
4transport vesicle membraneGO:00306589.3HLA-DRB1, HLA-DQB1
5ER to Golgi transport vesicle membraneGO:00125079.2HLA-DRB1, HLA-DQB1
6trans-Golgi network membraneGO:00325889.2HLA-DQB1, HLA-DRB1
7endocytic vesicle membraneGO:00306669.1HLA-DRB1, HLA-DQB1
8Golgi membraneGO:00001399.1HLA-DRB1, HLA-DQB1
9external side of plasma membraneGO:00098978.9PDCD1, HLA-DRB1
10lysosomal membraneGO:00057658.8HLA-DRB1, HLA-DQB1

Biological processes related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.3HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.2HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DQB1, HLA-DRB1
4T cell receptor signaling pathwayGO:00508529.1HLA-DRB1, HLA-DQB1
5immune responseGO:00069559.1HLA-DRB1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.0HLA-DRB1, HLA-DQB1
7cytokine-mediated signaling pathwayGO:00192218.8HLA-DRB1, HLA-DQB1
8T cell costimulationGO:00312958.7PDCD1, HLA-DRB1, HLA-DQB1

Molecular functions related to Multiple Sclerosis, Disease Progression, Modifier of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Multiple Sclerosis, Disease Progression, Modifier of

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  • Antibodies
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Sources for Multiple Sclerosis, Disease Progression, Modifier of

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet