MCID: MLT002
MIFTS: 39

Multiple Symmetrical Lipomatosis malady

Categories: Genetic diseases (common), Skin diseases

Aliases & Classifications for Multiple Symmetrical Lipomatosis

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Aliases & Descriptions for Multiple Symmetrical Lipomatosis:

Name: Multiple Symmetrical Lipomatosis 10 12
Lipomatosis, Familial Benign Cervical 65
 
Lipomatosis, Multiple Symmetrical 65

Classifications:



External Ids:

Disease Ontology10 DOID:3137
MeSH36 D008069
UMLS65 C0023804

Summaries for Multiple Symmetrical Lipomatosis

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MalaCards based summary: Multiple Symmetrical Lipomatosis, also known as lipomatosis, familial benign cervical, is related to obesity and multiple symmetric lipomatosis. An important gene associated with Multiple Symmetrical Lipomatosis is MFN2 (Mitofusin 2), and among its related pathways are Adipocytokine signaling pathway and amb2 Integrin signaling. Affiliated tissues include lung, prostate and liver, and related mouse phenotypes are adipose tissue and liver/biliary system.

Related Diseases for Multiple Symmetrical Lipomatosis

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Diseases related to Multiple Symmetrical Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1obesity28.4ADIPOQ, IL6, LEP, MFN2, RETN, UCP1
2multiple symmetric lipomatosis12.5
3madelung disease11.5
4lipomatosis10.9
5familial lipoprotein lipase deficiency10.5MFN2, UCP1
6nondystrophic myotonia10.3ADIPOQ, LEP
7noonan-like/multiple giant cell lesion syndrome10.3ADIPOQ, LEP
8congenital chloride diarrhea10.3ADIPOQ, IL6
9anterior cruciate ligament tears10.3ADIPOQ, IL6
10tenosynovial giant cell tumor10.3ADIPOQ, LEP
11primary hypertrophic osteoarthropathy10.2ADIPOQ, LEP
12neuropathy10.2
13conjunctivochalasis10.2ADIPOQ, IL6
14hellp syndrome10.2ADIPOQ, LEP
15hidrocystoma10.1IL6, LEP
16hepatic flexure cancer10.1IL6, LEP
17eccrine sweat gland neoplasm10.1IL6, SELP
18viral exanthem10.1ADIPOQ, LEP
19leptospirosis10.1IL6, LEP
20heterophyiasis10.1IL6, SELP
21disease of mental health10.0IL6, LEP
22intraocular lymphoma10.0IL6, SELP
23dermoid cyst of ovary10.0IL6, LEP
24laryngitis10.0
25myopathy10.0
26acquired hemophilia9.9ADIPOQ, LEP, RETN
27lethal infantile mitochondrial myopathy9.9ADIPOQ, LEP, RETN
28pre-eclampsia9.9LEP, VCAM1
29dermal unilateral segmental cavernous angioma9.9ADIPOQ, LEP, RETN
30acatalasemia9.9ADIPOQ, LEP, RETN
31prediabetes syndrome9.9ADIPOQ, LEP, RETN
32ochronosis9.9ADIPOQ, LEP, RETN
33lactose intolerance9.9ADIPOQ, LEP, RETN
34large intestine lipoma9.9IL6, VCAM1
35pyrimidine metabolic disorder9.9IL6, VCAM1
36hyperalphalipoproteinemia9.9
37lipoma9.9
38sleep apnea9.9
39peripheral neuropathy9.9
40autonomic neuropathy9.9
41gynecomastia9.9
42polyneuropathy9.9
43merrf syndrome9.9
44plexopathy9.9
45thyroiditis9.9
46mitochondrial disorders9.9
47encephalomyopathy9.9
48myoclonus epilepsy9.9
49multiple endocrine neoplasia9.9
50encephalopathy9.9

Graphical network of the top 20 diseases related to Multiple Symmetrical Lipomatosis:



Diseases related to multiple symmetrical lipomatosis

Symptoms for Multiple Symmetrical Lipomatosis

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Drugs & Therapeutics for Multiple Symmetrical Lipomatosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Multiple Symmetrical Lipomatosis

Genetic Tests for Multiple Symmetrical Lipomatosis

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Anatomical Context for Multiple Symmetrical Lipomatosis

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MalaCards organs/tissues related to Multiple Symmetrical Lipomatosis:

33
Lung, Prostate, Liver, Endothelial, Skin, Brain, Kidney

Animal Models for Multiple Symmetrical Lipomatosis or affiliated genes

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MGI Mouse Phenotypes related to Multiple Symmetrical Lipomatosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.4ADIPOQ, IL6, LEP, RETN, UCP1
2MP:00053708.3ADIPOQ, IL6, LEP, RETN, SELP
3MP:00053908.1ADIPOQ, IL6, LEP, MFN2, SELP
4MP:00053867.9ADIPOQ, IL6, LEP, MFN2, SELP, UCP1
5MP:00053847.0ADIPOQ, IL6, LEP, MFN2, SELP, UCP1
6MP:00053786.8ADIPOQ, IL6, LEP, MFN2, SELP, UCP1
7MP:00053856.6ADIPOQ, IL6, LEP, MFN2, SELP, UCP1
8MP:00053766.5ADIPOQ, IL6, LEP, MFN2, RETN, SELP

Publications for Multiple Symmetrical Lipomatosis

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Articles related to Multiple Symmetrical Lipomatosis:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Multiple symmetric lipomatosis with spindle cell proliferation. (26922721)
2016
2
Multiple Symmetric Lipomatosis Presenting with Bilateral Brachial Plexopathy. (26256662)
2015
3
Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis. (26180731)
2015
4
Power-assisted liposuction (PAL) of multiple symmetric lipomatosis (MSL)-a longitudinal study. (25393046)
2014
5
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
6
Impaired gonadal function in a woman with multiple symmetric lipomatosis. (23732376)
2013
7
Multiple symmetric lipomatosis: a review of 3 cases. (22953128)
2012
8
Surgical approach in a patient with multiple symmetrical lipomatosis: case report. (22392254)
2012
9
Multiple symmetric lipomatosis type I in a female patient with neuropathy: no association with alcoholism or mitochondrial DNA m.8344A>G mutation. (23142763)
2012
10
Multiple symmetrical lipomatosis: case report and literature review. (22583757)
2012
11
Multiple symmetric lipomatosis. (21781630)
2011
12
Multiple symmetric lipomatosis: substantial subcutaneous adipose tissue accumulation did not induce glucose and lipid metabolism dysfunction. (20714139)
2010
13
Central form of multiple symmetric lipomatosis: a case report. (19918431)
2009
14
Multiple symmetric lipomatosis in two chinese patients, one typical and one unusual. (24257048)
2009
15
From ancient enigmas to novel paradigms: a depiction of multiple symmetric lipomatosis. (18756923)
2008
16
Multiple symmetric lipomatosis type 2 in females--report of two cases. (18358107)
2008
17
Multiple symmetric lipomatosis - a reflection of new concepts about obesity. (18367347)
2008
18
Multiple symmetric lipomatosis: case report and review of the literature. (17577504)
2007
19
Multiple symmetric lipomatosis (MSL) of neck in a child (Madelung's disease): report of a rare presentation. (17329589)
2007
20
Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity? (14988304)
2004
21
Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity? Response to Haap et al. (15220292)
2004
22
Multiple symmetric lipomatosis: Korean experience. (12614415)
2003
23
Differential clinical expression of multiple symmetric lipomatosis in men and women. (14574355)
2003
24
Multiple Symmetric Lipomatosis (Madelung's Disease) Caused by the MERRF (A8344G) Mutation: A Report of Two Cases and Review of the Literature. (19078716)
2003
25
Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. (11850759)
2002
26
Wernicke's encephalopathy in a patient with multiple symmetrical lipomatosis and the A8344G mutation of mitochondrial DNA. (11844905)
2002
27
Multiple symmetrical lipomatosis (Madelung's disease). (11150043)
2001
28
Multiple symmetric lipomatosis: evidence for mitochondrial dysfunction. (19078570)
2000
29
Ultrasound, CT and MRI in patients with multiple symmetric lipomatosis. (10650121)
2000
30
Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis. (10440290)
1999
31
Encephalomyopathy with multiple mitochondrial DNA deletions and multiple symmetric lipomatosis: further evidence of a possible association. (10653316)
1999
32
Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA. (9674814)
1998
33
Multiple symmetric lipomatosis in the Chinese: ultrasound, CT and MR imaging. (9867274)
1998
34
Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis. (9879833)
1998
35
Multiple symmetric lipomatosis presenting with polyneuropathy. (7591705)
1995
36
RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas. (7531972)
1995
37
Multiple symmetrical lipomatosis: no longer just a Mediterranean disease? (8202317)
1994
38
Multiple symmetric lipomatosis: abnormalities in complex IV and multiple deletions in mitochondrial DNA. (8190288)
1994
39
An uncommon presentation of multiple symmetric lipomatosis. (8407077)
1993
40
Multiple symmetrical lipomatosis. (1521476)
1992
41
Multiple symmetrical lipomatosis in the neck. (1524810)
1992
42
Multiple symmetric lipomatosis. (3267365)
1988
43
Multiple symmetric lipomatosis: treatment with liposuction. (3346417)
1988
44
Neuropathy in multiple symmetric lipomatosis. Madelung's disease. (3179687)
1988
45
Multiple symmetric lipomatosis: report of two cases and review of the literature. (3799134)
1986
46
Multiple symmetrical lipomatosis in a patient with HA1rthle cell carcinoma of the thyroid: a case report. (3941586)
1986
47
Impairment of cardiovascular autonomic reflexes in multiple symmetric lipomatosis. (6491158)
1984
48
Multiple symmetric lipomatosis: an updated clinical report. (6318013)
1984
49
Ultrastructural features of cultured mature adipocyte precursors from adipose tissue in multiple symmetric lipomatosis. (6670139)
1983
50
Adrenergic regulation of fat-cell lipolysis in multiple symmetric lipomatosis. (6129978)
1982

Variations for Multiple Symmetrical Lipomatosis

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Expression for genes affiliated with Multiple Symmetrical Lipomatosis

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Search GEO for disease gene expression data for Multiple Symmetrical Lipomatosis.

Pathways for genes affiliated with Multiple Symmetrical Lipomatosis

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GO Terms for genes affiliated with Multiple Symmetrical Lipomatosis

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Cellular components related to Multiple Symmetrical Lipomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1IL6, VCAM1

Biological processes related to Multiple Symmetrical Lipomatosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1fatty acid beta-oxidationGO:000663510.2ADIPOQ, LEP
2brown fat cell differentiationGO:005087310.2ADIPOQ, UCP1
3negative regulation of gluconeogenesisGO:004572110.1ADIPOQ, IL6
4positive regulation of STAT protein import into nucleusGO:200036610.1IL6, LEP
5negative regulation of hormone secretionGO:004688810.0ADIPOQ, IL6
6negative regulation of fat cell differentiationGO:00455999.9ADIPOQ, IL6
7positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, LEP
8response to glucocorticoidGO:00513849.9ADIPOQ, IL6
9negative regulation of lipid storageGO:00108889.9IL6, LEP
10response to nutrientGO:00075849.8ADIPOQ, LEP
11regulation of angiogenesisGO:00457659.8IL6, LEP
12positive regulation of MAPK cascadeGO:00434109.8IL6, LEP
13positive regulation of smooth muscle cell proliferationGO:00486619.8IL6, RETN
14leukocyte tethering or rollingGO:00509019.7LEP, VCAM1
15positive regulation of protein kinase B signalingGO:00518979.7IL6, LEP
16positive regulation of T cell proliferationGO:00421029.6LEP, VCAM1
17calcium-mediated signaling using intracellular calcium sourceGO:00355849.5SELP, VCAM1
18response to nutrient levelsGO:00316679.5ADIPOQ, IL6, LEP
19response to ethanolGO:00454719.4ADIPOQ, LEP
20defense response to Gram-negative bacteriumGO:00508299.4IL6, SELP
21response to insulinGO:00328689.4IL6, LEP, RETN
22cellular response to tumor necrosis factorGO:00713569.1IL6, VCAM1
23single organismal cell-cell adhesionGO:00163378.7SELP, VCAM1

Sources for Multiple Symmetrical Lipomatosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet