MCID: MLT002
MIFTS: 36

Multiple Symmetrical Lipomatosis malady

Categories: Genetic diseases (common), Skin diseases

Aliases & Classifications for Multiple Symmetrical Lipomatosis

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Aliases & Descriptions for Multiple Symmetrical Lipomatosis:

Name: Multiple Symmetrical Lipomatosis 11 13
Lipomatosis, Familial Benign Cervical 66
 
Lipomatosis, Multiple Symmetrical 66

Classifications:



External Ids:

Disease Ontology11 DOID:3137
MeSH37 D008069

Summaries for Multiple Symmetrical Lipomatosis

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MalaCards based summary: Multiple Symmetrical Lipomatosis, also known as lipomatosis, familial benign cervical, is related to obesity and lipomatosis, multiple symmetric. An important gene associated with Multiple Symmetrical Lipomatosis is MLXIPL (MLX Interacting Protein Like), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and African trypanosomiasis. Affiliated tissues include skin, adipocyte and thyroid, and related mouse phenotypes are adipose tissue and renal/urinary system.

Related Diseases for Multiple Symmetrical Lipomatosis

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Diseases related to Multiple Symmetrical Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1obesity28.4ADIPOQ, IL6, LEP, MFN2, RETN, UCP1
2lipomatosis, multiple symmetric11.9
3madelung disease11.5
4lipomatosis10.9
5malignant spindle cell melanoma10.5MFN2, UCP1
6noninfectious dermatoses of eyelid10.5MFN2, MT-TK
7familial drusen10.4ADIPOQ, RETN
8lymphoepithelioma-like carcinoma10.3MFN2, MT-TK
9stiff-person syndrome10.3MFN2, MT-TK, UCP1
10nondystrophic myotonia10.3ADIPOQ, LEP
11potato nose10.3ADIPOQ, LEP
12scleredema adultorum10.2ADIPOQ, LEP
13neuropathy10.2
14muscle hypertrophy10.2GSK3B, LEP
15patellofemoral pain syndrome10.1ADIPOQ, LEP
16urinary bladder posterior wall cancer10.1IL6, LEP
17histoplasmosis10.1IL6, SELP
18colon carcinoma in situ10.0IL6, SELP
19laryngitis10.0
20myopathy10.0
21benign peritoneal mesothelioma9.9IL6, RETN
22keratoacanthoma9.9ADIPOQ, LEP
23pure mitochondrial myopathy9.9ADIPOQ, LEP, RETN
24hyperalphalipoproteinemia9.9
25lipoma9.9
26sleep apnea9.9
27autonomic neuropathy9.9
28gynecomastia9.9
29polyneuropathy9.9
30epilepsy9.9
31plexopathy9.9
32thyroiditis9.9
33mitochondrial disorders9.9
34encephalomyopathy9.9
35myoclonus epilepsy9.9
36multiple endocrine neoplasia9.9
37encephalopathy9.9
38myoclonus9.9
39west nile fever9.9IL6, VCAM1
40neonatal diabetes mellitus9.9ADIPOQ, LEP, RETN
41ischemic heart disease9.9IL6, SELP
42acatalasemia9.9ADIPOQ, LEP, RETN
43orbital lymphangioma9.8IL6, VCAM1
44antidepressant type abuse9.8ADIPOQ, IL6, LEP
45apocrine adenoma9.8IL6, LEP
46diabetic encephalopathy9.8ADIPOQ, IL6, LEP
47periampullary adenoma9.8ADIPOQ, IL6, LEP
48dementia - subcortical9.8IL6, VCAM1
49hypertrichosis9.8ADIPOQ, IL6, LEP
50intracranial primitive neuroectodermal tumor9.8SELP, VCAM1

Graphical network of the top 20 diseases related to Multiple Symmetrical Lipomatosis:



Diseases related to multiple symmetrical lipomatosis

Symptoms for Multiple Symmetrical Lipomatosis

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Drugs & Therapeutics for Multiple Symmetrical Lipomatosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Insight Into Subcutaneous Adipose Tissue DisordersRecruitingNCT02838277

Search NIH Clinical Center for Multiple Symmetrical Lipomatosis

Genetic Tests for Multiple Symmetrical Lipomatosis

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Anatomical Context for Multiple Symmetrical Lipomatosis

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MalaCards organs/tissues related to Multiple Symmetrical Lipomatosis:

34
Skin, Adipocyte, Thyroid

Animal Models for Multiple Symmetrical Lipomatosis or affiliated genes

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MGI Mouse Phenotypes related to Multiple Symmetrical Lipomatosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1ADIPOQ, IL6, LEP, MLXIPL, RETN, UCP1
2MP:00053678.0ADIPOQ, GSK3B, IL6, LEP, SELP
3MP:00053907.7ADIPOQ, GSK3B, IL6, LEP, MFN2, SELP
4MP:00053707.7ADIPOQ, GSK3B, IL6, LEP, MLXIPL, RETN
5MP:00053857.0ADIPOQ, GSK3B, IL6, LEP, MFN2, SELP
6MP:00053786.5ADIPOQ, GSK3B, IL6, LEP, MFN2, SELP
7MP:00053765.5ADIPOQ, GSK3B, IL6, LEP, MFN2, MLXIPL

Publications for Multiple Symmetrical Lipomatosis

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Articles related to Multiple Symmetrical Lipomatosis:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Multiple Symmetric Lipomatosis Presenting with Bilateral Brachial Plexopathy. (26256662)
2015
2
Multiple Symmetric Lipomatosis (Madelung's Disease) Presenting as Bilateral Huge Gynecomastia. (25548590)
2014
3
Multiple symmetric lipomatosis: an unusual case. (23621501)
2014
4
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
5
Impaired gonadal function in a woman with multiple symmetric lipomatosis. (23732376)
2013
6
Multiple symmetric lipomatosis: a diagnostic dilemma. (23983713)
2013
7
Surgical Treatment of Multiple Symmetric Lipomatosis With Ultrasound-Assisted Liposuction. (23657050)
2013
8
Multiple symmetric lipomatosis: a review of 3 cases. (22953128)
2012
9
Multiple symmetrical lipomatosis: case report and literature review. (22583757)
2012
10
Growing fatty mass in the back: diagnosis of a multiple symmetric lipomatosis (Madelung's disease) in association with chronic alcoholism. (22075714)
2012
11
Cardiac noradrenergic denervation in a patient with multiple symmetric lipomatosis. (22441442)
2012
12
Multiple symmetric lipomatosis: substantial subcutaneous adipose tissue accumulation did not induce glucose and lipid metabolism dysfunction. (20714139)
2010
13
From ancient enigmas to novel paradigms: a depiction of multiple symmetric lipomatosis. (18756923)
2008
14
Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity? Response to Haap et al. (15220292)
2004
15
Differential clinical expression of multiple symmetric lipomatosis in men and women. (14574355)
2003
16
Multiple Symmetric Lipomatosis (Madelung's Disease) Caused by the MERRF (A8344G) Mutation: A Report of Two Cases and Review of the Literature. (19078716)
2003
17
Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. (11850759)
2002
18
Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells. (12375271)
2002
19
Multiple symmetrical lipomatosis (Madelung's disease). (11150043)
2001
20
Are 'buffalo hump' syndrome, Madelung's disease and multiple symmetrical lipomatosis variants of the same dysmetabolism? (11216947)
2001
21
Multiple symmetric lipomatosis: evidence for mitochondrial dysfunction. (19078570)
2000
22
Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. (10817486)
2000
23
Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis. (10440290)
1999
24
A case of multiple symmetrical lipomatosis (Madelung's disease). (10419045)
1999
25
Multiple Symmetric Lipomatosis--MR appearances. (10580773)
1999
26
Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA. (9674814)
1998
27
Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis. (9879833)
1998
28
Mitochondrial DNA mutations in multiple symmetric lipomatosis. (9309699)
1997
29
Laryngeal involvement in multiple symmetric lipomatosis: the role of computed tomography in diagnosis. (9074739)
1997
30
Multiple symmetrical lipomatosis (Madelung's disease): a case report. (8915118)
1996
31
Multiple symmetric lipomatosis presenting with polyneuropathy. (7591705)
1995
32
RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas. (7531972)
1995
33
Multiple symmetric lipomatosis (Madelung's disease). (7709262)
1995
34
Multiple symmetrical lipomatosis: computed tomographic appearance. (7777892)
1995
35
Mitochondrial respiratory function in multiple symmetrical lipomatosis: report of two cases. (7858441)
1994
36
An uncommon presentation of multiple symmetric lipomatosis. (8407077)
1993
37
Extremely high HDL levels in a patient with multiple symmetric lipomatosis. (8143360)
1993
38
Multiple symmetrical lipomatosis. (1521476)
1992
39
Multiple symmetric lipomatosis: combined surgical treatment and liposuction. Case report. (1626219)
1992
40
Mitochondrial dysfunction in multiple symmetrical lipomatosis. (1650162)
1991
41
A case of multiple symmetric lipomatosis (Madelung's disease). (2690720)
1989
42
Multiple symmetric lipomatosis. (3267365)
1988
43
Multiple symmetric lipomatosis: treatment with liposuction. (3346417)
1988
44
Neuropathy in multiple symmetric lipomatosis. Madelung's disease. (3179687)
1988
45
Multiple symmetrical lipomatosis in a patient with HA1rthle cell carcinoma of the thyroid: a case report. (3941586)
1986
46
Sensory, motor, and autonomic neuropathy in patients with multiple symmetric lipomatosis. (4058304)
1985
47
Metabolic abnormalities in multiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissue with hyperalphalipoproteinemia. (6875381)
1983
48
Adrenergic regulation of fat-cell lipolysis in multiple symmetric lipomatosis. (6129978)
1982
49
Computed tomography of deep fat masses in multiple symmetrical lipomatosis. (7089242)
1982
50
Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis. (6256016)
1980

Variations for Multiple Symmetrical Lipomatosis

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Expression for genes affiliated with Multiple Symmetrical Lipomatosis

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Search GEO for disease gene expression data for Multiple Symmetrical Lipomatosis.

Pathways for genes affiliated with Multiple Symmetrical Lipomatosis

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GO Terms for genes affiliated with Multiple Symmetrical Lipomatosis

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Cellular components related to Multiple Symmetrical Lipomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7IL6, SELP, VCAM1
2extracellular spaceGO:00056157.1ADIPOQ, IL6, LEP, RETN, SELP, VCAM1

Biological processes related to Multiple Symmetrical Lipomatosis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:005087310.3ADIPOQ, UCP1
2negative regulation of smooth muscle cell proliferationGO:004866210.2ADIPOQ, MFN2
3negative regulation of hormone secretionGO:004688810.2ADIPOQ, IL6
4negative regulation of MAP kinase activityGO:004340710.1ADIPOQ, GSK3B
5positive regulation of STAT protein import into nucleusGO:200036610.1IL6, LEP
6cellular response to hepatocyte growth factor stimulusGO:003572910.1GSK3B, IL6
7negative regulation of gluconeogenesisGO:004572110.1ADIPOQ, IL6
8fatty acid beta-oxidationGO:000663510.0ADIPOQ, LEP
9negative regulation of fat cell differentiationGO:004559910.0ADIPOQ, IL6
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9IL6, LEP
11negative regulation of lipid storageGO:00108889.9IL6, LEP
12regulation of angiogenesisGO:00457659.9IL6, LEP
13positive regulation of JAK-STAT cascadeGO:00464279.8IL6, LEP
14positive regulation of smooth muscle cell proliferationGO:00486619.6GSK3B, IL6, RETN
15leukocyte cell-cell adhesionGO:00071599.6SELP, VCAM1
16defense response to Gram-negative bacteriumGO:00508299.6IL6, SELP
17acute inflammatory responseGO:00025269.5IL6, VCAM1
18calcium-mediated signaling using intracellular calcium sourceGO:00355849.4SELP, VCAM1
19response to activityGO:00148239.3ADIPOQ, GSK3B, LEP
20response to nutrient levelsGO:00316679.3ADIPOQ, IL6, LEP
21circadian rhythmGO:00076239.2ADIPOQ, GSK3B, LEP
22leukocyte tethering or rollingGO:00509019.1LEP, SELP, VCAM1
23response to nutrientGO:00075849.1ADIPOQ, LEP, VCAM1
24glucose homeostasisGO:00425939.1ADIPOQ, IL6, LEP, MLXIPL
25response to insulinGO:00328689.1GSK3B, IL6, LEP, RETN
26positive regulation of T cell proliferationGO:00421028.9IL6, LEP, VCAM1
27response to lipopolysaccharideGO:00324968.8IL6, SELP, VCAM1
28response to hypoxiaGO:00016668.6ADIPOQ, LEP, VCAM1
29agingGO:00075688.6GSK3B, IL6, RETN, VCAM1
30response to ethanolGO:00454718.4ADIPOQ, LEP, VCAM1

Molecular functions related to Multiple Symmetrical Lipomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:00336919.8ADIPOQ, SELP
2hormone activityGO:00051799.1ADIPOQ, LEP, RETN

Sources for Multiple Symmetrical Lipomatosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet