MSA
MCID: MLT021
MIFTS: 71

Multiple System Atrophy (MSA) malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Multiple System Atrophy

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NIH Rare Diseases:42 Multiple system atrophy (msa) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  msa affects both men and women primarily in their 50s.  the disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. the cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested. there is no cure for this condition, and there is no known way to prevent the disease from getting worse. the goal of treatment is to control symptoms.  last updated: 10/7/2010

MalaCards based summary: Multiple System Atrophy, also known as shy-drager syndrome, is related to progressive supranuclear palsy and parkinson's disease, and has symptoms including An important gene associated with Multiple System Atrophy is COQ2 (coenzyme Q2 4-hydroxybenzoate polyprenyltransferase), and among its related pathways are Parkinsons Disease Pathway and Alpha-synuclein signaling. The compounds thioflavine s and methionine sulfoxide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are taste/olfaction and integument.

Genetics Home Reference:21 Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.

NINDS:43 Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects both men and women primarily in their 50s.

Wikipedia:65 Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the... more...

Description from OMIM:46 146500

Aliases & Classifications for Multiple System Atrophy

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Multiple System Atrophy, Aliases & Descriptions:

Name: Multiple System Atrophy 30 8 42 21 43 46 10 44 48 62
Shy-Drager Syndrome 8 21 43 62
Msa 42 21 48
Striatonigral Degeneration 21 62
 
Multi System Atrophy 62
Multisystem Atrophy 48
Opca 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
multiple system atrophy:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:4752
OMIM46 146500
MeSH34 D012791
NCIt39 C85066
SNOMED-CT57 230297002, 16576004
MESH via Orphanet35 D019578
ICD10 via Orphanet26 G90.3
UMLS via Orphanet63 C0393571

Related Diseases for Multiple System Atrophy

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Diseases related to Multiple System Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy31.9SLC6A3
2parkinson's disease30.9DRD2, SLC6A3, SNCA, SNCB, RPS27A
3lewy body dementia30.9SNCB, SNCA
4spinocerebellar ataxia30.8RPS27A, SNCA, FMR1
5rem sleep behavior disorder30.7SNCA, SLC6A3
6machado-joseph disease30.5SLC6A3, RPS27A, SNCA
7striatonigral degeneration30.5DRD2, SNCA, SLC6A3, RPS27A
8essential tremor30.4SNCA, SLC6A3, FMR1
9tauopathy30.4RPS27A, SNCA
10huntington's disease30.3DRD2, CHAT
11motor neuron disease30.3SQSTM1, RPS27A, SNCA
12myositis30.2SNCA, RPS27A
13myotonic dystrophy30.2FMR1, CRYAB
14dementia29.7SNCA, CHAT, RPS27A, FMR1, SQSTM1, SNCB
15pick's disease29.5CRYAB, SQSTM1, CHAT, RPS27A, SNCA
16breast cancer29.1SNCA, DRD2, CRYAB, RPS27A, SQSTM1
17alzheimer's disease28.9RPS27A, SQSTM1, CRYAB, SNCA, SLC6A3, CHAT
18pure autonomic failure10.7
19neuronitis10.7
20striatonigral degeneration infantile10.6
21ataxia10.6
22olivopontocerebellar atrophy10.6
23synucleinopathy10.6
24cerebritis10.6
25multiple system atrophy with orthostatic hypotension10.5
26autonomic dysfunction10.5
27neuronal intranuclear inclusion disease10.4RPS27A
28oppositional defiant disorder10.4SLC6A3
29corticobasal degeneration10.4
30dysautonomia10.4
31cerebellar ataxia10.4
32sleep disorder10.4
33tremor10.4
34multiple system atrophy, cerebellar type10.4
35bullous pemphigoid10.4
36cerebellar degeneration10.4
37torsion dystonia10.4
38neuroleptic malignant syndrome10.3
39sporadic infantile bilateral striatal necrosis10.3
40neuroaxonal dystrophy10.3RPS27A, SNCA
41spinocerebellar ataxia type 710.3
42alexander disease10.3RPS27A, CRYAB
43myofibrillar myopathy10.3RPS27A, CRYAB
44amyotrophic lateral sclerosis10.3
45lateral sclerosis10.3
46apraxia10.3
47dystonia10.3
48respiratory failure10.3
49multiple system atrophy, parkinsonian type10.3
50nicotine dependence10.2DRD2

Graphical network of the top 20 diseases related to Multiple System Atrophy:



Diseases related to multiple system atrophy

Symptoms for Multiple System Atrophy

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Symptoms by clinical synopsis from OMIM:

146500

Clinical features from OMIM:

146500

HPO human phenotypes related to Multiple System Atrophy:

(show all 30)
id Description Frequency HPO Source Accession
1 cognitive impairment rare (5%) HP:0100543
2 autosomal dominant inheritance HP:0000006
3 autosomal recessive inheritance HP:0000007
4 urinary urgency HP:0000012
5 urinary incontinence HP:0000020
6 ptosis HP:0000508
7 gaze-evoked nystagmus HP:0000640
8 impotence HP:0000802
9 hypohidrosis HP:0000966
10 anhidrosis HP:0000970
11 iris atrophy HP:0001089
12 ataxia HP:0001251
13 dysarthria HP:0001260
14 orthostatic hypotension HP:0001278
15 parkinsonism HP:0001300
16 tremor HP:0001337
17 hyperreflexia HP:0001347
18 abnormality of metabolism/homeostasis HP:0001939
19 rigidity HP:0002063
20 bradykinesia HP:0002067
21 postural instability HP:0002172
22 neurodegeneration HP:0002180
23 dysautonomia HP:0002459
24 olivopontocerebellar atrophy HP:0002542
25 amyotrophy HP:0003202
26 babinski sign HP:0003487
27 adult onset HP:0003581
28 progressive disorder HP:0003676
29 sporadic HP:0003745
30 phenotypic variability HP:0003812

Drugs & Therapeutics for Multiple System Atrophy

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Drug clinical trials:

Search ClinicalTrials for Multiple System Atrophy

Search NIH Clinical Center for Multiple System Atrophy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple System Atrophy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple System Atrophy:
Mesenchymal stem cells for multiple system atrophy
Embryonic/Adult Cultured Cells Related to Multiple System Atrophy:
Bone marrow-derived mesenchymal stem cells, PMID: 19513327

Genetic Tests for Multiple System Atrophy

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Anatomical Context for Multiple System Atrophy

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MalaCards organs/tissues related to Multiple System Atrophy:

32
Brain, Testes, Bone, Bone marrow, Eye, Skin, Cortex, Heart, Colon, Whole blood, Cerebellum, Skeletal muscle, Temporal lobe, Olfactory bulb, Subthalamic nucleus, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple System Atrophy:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Multiple System Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Multiple System Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.9SLC6A3, DRD2, SNCA
2MP:00107717.7SNCA, FMR1, SQSTM1, DRD2, SLC6A3
3MP:00053897.6CHAT, SNCA, FMR1, DRD2, SLC6A3
4MP:00053907.4CHAT, SNCA, SQSTM1, CRYAB, DRD2, SLC6A3
5MP:00053767.3SLC6A3, DRD2, SQSTM1, SNCB, SNCA, CHAT
6MP:00053867.0CHAT, SNCA, FMR1, SQSTM1, CRYAB, DRD2
7MP:00107686.9CHAT, SNCA, SNCB, SQSTM1, CRYAB, DRD2
8MP:00036316.7SLC6A3, CHAT, SNCA, SNCB, FMR1, SQSTM1
9MP:00053786.7CHAT, SNCA, SNCB, FMR1, SQSTM1, CRYAB

Publications for Multiple System Atrophy

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Articles related to Multiple System Atrophy:

(show top 50)    (show all 697)
idTitleAuthorsYear
1
Update on novel familial forms of Parkinson's disease and multiple system atrophy. (24262183)
2014
2
XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. (23993308)
2014
3
The basal ganglia in perceptual timing: Timing performance in Multiple System Atrophy and Huntington's disease. (24135486)
2014
4
Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins. (23948991)
2013
5
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. (24243499)
2013
6
Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. (22806758)
2012
7
The neuropathology, pathophysiology and genetics of multiple system atrophy. (22074330)
2012
8
"Hot cross bun" sign in multiple system atrophy with predominant cerebellar ataxia: a comparison between proton density-weighted imaging and T2-weighted imaging. (22209432)
2012
9
Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease. (22371705)
2012
10
Post mortem cerebrospinal fluid I+-synuclein levels are raised in multiple system atrophy and distinguish this from the other I+-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. (21856424)
2012
11
Serum urate levels are not associated with survival in multiple system atrophy. (21354851)
2011
12
Uric acid as a potential disease modifier in patients with multiple system atrophy. (21542015)
2011
13
Diagnostic performance of iodine-123-metaiodobenzylguanidine scintigraphy in differential diagnosis between Parkinson's disease and multiple-system atrophy: a systematic review and a meta-analysis. (21962800)
2011
14
Genetic players in multiple system atrophy: unfolding the nature of the beast. (21601954)
2011
15
Nonmotor presentations of multiple system atrophy. (21343894)
2011
16
A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. (20176003)
2010
17
Multiple-system atrophy presenting with low rectal compliance and bowel pain. (20629156)
2010
18
Whole body and cardiac metaiodobenzylguanidine kinetics in Parkinson disease and multiple system atrophy: implications for the diagnostic role of imaging. (20395701)
2010
19
White matter hyperintensities in patients with multiple system atrophy. (19468782)
2009
20
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy. (19514077)
2009
21
Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death. (19429902)
2009
22
A validation exercise on the new consensus criteria for multiple system atrophy. (19845011)
2009
23
Multiple system atrophy: a primary oligodendrogliopathy. (18825660)
2008
24
Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy. (18178568)
2008
25
Loss of A5 noradrenergic neurons in multiple system atrophy. (18297292)
2008
26
PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease. (18236005)
2008
27
Multiple system atrophy: alpha-synuclein and neuronal degeneration. (18018485)
2007
28
Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy. (17139443)
2007
29
Abnormal temporal discrimination threshold in patients with multiple system atrophy. (17260339)
2007
30
Paradoxical vocal cord motion: a review focused on multiple system atrophy. (17482397)
2007
31
Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy. (17235127)
2007
32
Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy. (17544807)
2007
33
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. (18018479)
2007
34
Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. (17291816)
2007
35
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. (17485650)
2007
36
Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. (17562934)
2007
37
Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy. (17603243)
2007
38
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
39
Hyperintensity of the middle cerebellar peduncles on fluid-attenuated inversion recovery imaging: variation with age and implications for the diagnosis of multiple system atrophy. (17110685)
2006
40
CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia. (16894110)
2006
41
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). (15583958)
2005
42
Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy. Case report. (15035294)
2004
43
Involvement of medullary serotonergic groups in multiple system atrophy. (14991820)
2004
44
Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy). (12764627)
2003
45
Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy. (14639688)
2003
46
The pathogenesis of multiple system atrophy: past, present, and future. (11009180)
2000
47
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease. (9452329)
1998
48
Olivopontocerebellar atrophy and multiple system atrophy: clinical follow-up of 10 patients studied with PET. (9667610)
1998
49
A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy. (7876880)
1995
50
Whole blood monoamine oxidase activity in Parkinson's disease and multiple system atrophy patients. (8410065)
1993

Variations for Multiple System Atrophy

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UniProtKB/Swiss-Prot genetic disease variations for Multiple System Atrophy:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1COQ2p.Phe29LeuVAR_070239
2COQ2p.Pro49HisVAR_070240
3COQ2p.Ser57ThrVAR_070241
4COQ2p.Met78ValVAR_070243
5COQ2p.Ile97ThrVAR_070244
6COQ2p.Pro107SerVAR_070245
7COQ2p.Ser113PheVAR_070246
8COQ2p.Thr267AlaVAR_070247
9COQ2p.Ser297CysVAR_070248
10COQ2p.Arg337GlnVAR_070250
11COQ2p.Val343AlaVAR_070251

Clinvar genetic disease variations for Multiple System Atrophy:

6
id Gene Name Type Significance SNP ID Assembly Location
1COQ2COQ2, MET78VALundetermined variantrisk factor
2COQ2NM_015697.7(COQ2): c.1028T> C (p.Val343Ala)single nucleotide variantrisk factorrs397514727GRCh37Chr 4, 84188812: 84188812
3COQ2COQ2, ARG337TERundetermined variantrisk factor
4COQ2COQ2, ARG337GLNundetermined variantrisk factor

Expression for genes affiliated with Multiple System Atrophy

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Expression patterns in normal tissues for genes affiliated with Multiple System Atrophy

Search GEO for disease gene expression data for Multiple System Atrophy.

Pathways for genes affiliated with Multiple System Atrophy

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Pathways related to Multiple System Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SNCA, SLC6A3
29.6SLC6A3, SNCA
39.4FMR1, SNCB, SNCA
4
Show member pathways
8.6SLC6A3, DRD2, CHAT

Compounds for genes affiliated with Multiple System Atrophy

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Compounds related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.1SNCA, RPS27A
2methionine sulfoxide44 24 1112.1SNCA, CRYAB
31-benzyl-1,2,3,4-tetrahydroisoquinoline4410.1SNCA, SLC6A3
4acetyl-l-carnitine449.9FMR1, CHAT
5ibotenic acid449.8CHAT, SLC6A3
6rotenone449.6SLC6A3, RPS27A, SNCA
74-hydroxynonenal44 2410.5SNCA, CHAT, RPS27A
8ibzm449.5DRD2, SLC6A3
91 methyl 4 phenylpyridinium449.5SNCA, SLC6A3
10alpha-methyl-p-tyrosine449.5SLC6A3, DRD2
11tetrabenazine44 28 61 50 1113.5SLC6A3, DRD2
12d amphetamine449.5SLC6A3, DRD2
13dizocilpine449.5CHAT, DRD2
14raclopride44 2810.5DRD2, SLC6A3
15piperazine44 1110.4SLC6A3, DRD2
16sulpiride44 28 1111.4SLC6A3, DRD2
17choline44 24 1111.4SNCA, CHAT, SLC6A3
18trimipramine44 50 1111.4DRD2, SLC6A3
19methylphenidate44 50 1111.4SLC6A3, DRD2
20reserpine44 28 1111.4SLC6A3, DRD2
21valine449.3RPS27A, SLC6A3, SNCA
22maoa449.3DRD2, SLC6A3
23silver449.2RPS27A, FMR1, CHAT, SNCA
24amphetamine44 50 1111.2DRD2, SNCA, SLC6A3
25pirenzepine44 28 1111.2CHAT, DRD2
26pramipexole44 28 50 1112.1DRD2, SLC6A3
27quinpirole44 2810.1DRD2, SLC6A3
28paraffin449.1CRYAB, RPS27A, SNCA, CHAT
29heroin44 50 1111.0SLC6A3, DRD2, CHAT
30risperidone44 50 28 61 24 1114.0CHAT, DRD2, SLC6A3
31olanzapine44 50 28 24 1113.0SLC6A3, DRD2, CHAT
32haloperidol44 50 28 2 1113.0DRD2, CHAT, SLC6A3
335-hydroxytryptamine448.9DRD2, CHAT, SLC6A3
34testosterone44 61 24 1111.9RPS27A, SNCA, CHAT, FMR1
35aspartate448.9CHAT, RPS27A, CRYAB, SLC6A3
36h2o2448.8RPS27A, SNCB, CRYAB, SNCA, SLC6A3
37phencyclidine44 28 1110.8DRD2, SLC6A3
38nicotine44 28 50 1111.8DRD2, CHAT, SLC6A3
39mptp448.8SNCA, RPS27A, DRD2, SLC6A3
40levodopa44 119.8SNCA, RPS27A, DRD2, SLC6A3
41apomorphine28 44 1110.7SLC6A3, SNCA, CHAT, DRD2
42cocaine44 119.7SLC6A3, DRD2, SNCA, CHAT
43nmda44 289.5SLC6A3, DRD2, RPS27A, CHAT
44methamphetamine44 50 1110.3SNCA, CHAT, DRD2, SLC6A3, RPS27A
456-hydroxydopamine448.3CHAT, RPS27A, DRD2, SLC6A3, SNCA
46acetylcholine44 50 28 24 1112.3CHAT, SNCA, DRD2, SLC6A3, RPS27A
47dopamine44 28 24 1111.3SLC6A3, CHAT, DRD2, RPS27A, SNCA
48gaba448.2SLC6A3, DRD2, FMR1, RPS27A, CHAT
49norepinephrine44 24 1110.1SNCA, SQSTM1, DRD2, SLC6A3, CHAT
50glutamate447.9SNCA, RPS27A, FMR1, DRD2, SLC6A3, CHAT

GO Terms for genes affiliated with Multiple System Atrophy

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Cellular components related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.8SNCB, SNCA
2neuronal cell bodyGO:0430258.8SLC6A3, SNCB, CHAT
3mitochondrionGO:0057398.6CHAT, SNCA, SNCB, COQ2, CRYAB
4axonGO:0304248.4SLC6A3, DRD2, SNCA, CHAT
5cytoplasmGO:0057377.6NUB1, CHAT, SNCA, SNCB, FMR1, CRYAB

Biological processes related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1response to interferon-gammaGO:03434110.1SNCA, NUB1
2synapse organizationGO:05080810.0SNCA, SNCB
3dopamine biosynthetic processGO:04241610.0SNCA, SLC6A3
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.7CRYAB, SNCA
5neurotransmitter biosynthetic processGO:0421369.7CHAT, SLC6A3
6stress-activated MAPK cascadeGO:0514039.7CRYAB, RPS27A
7dopamine metabolic processGO:0424179.6DRD2, SNCB
8behavioral response to cocaineGO:0481489.6DRD2, SNCA
9regulation of long-term neuronal synaptic plasticityGO:0481699.6SNCA, DRD2
10agingGO:0075689.6SLC6A3, CRYAB, SNCA
11adenohypophysis developmentGO:0219849.5SLC6A3, DRD2
12response to iron ionGO:0100399.5DRD2, SLC6A3
13prepulse inhibitionGO:0601349.4DRD2, SLC6A3
14response to cocaineGO:0422209.4SLC6A3, DRD2
15response to nicotineGO:0350949.4DRD2, SLC6A3
16positive regulation of multicellular organism growthGO:0400189.3SLC6A3, DRD2
17adult walking behaviorGO:0076289.3DRD2, CHAT
18endosomal transportGO:0161979.3RPS27A, SQSTM1
19protein localizationGO:0081049.1SQSTM1, DRD2
20sensory perception of smellGO:0076089.1SLC6A3, DRD2
21negative regulation of apoptotic processGO:0430669.0SNCA, RPS27A, CRYAB, SQSTM1
22response to drugGO:0424939.0SLC6A3, SNCA, DRD2
23synaptic transmissionGO:0072688.8SNCB, CHAT, SLC6A3

Molecular functions related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:0484879.8SNCB, SNCA
2alpha-tubulin bindingGO:0430149.5SNCB, SNCA
3dopamine bindingGO:0352409.1SLC6A3, DRD2
4identical protein bindingGO:0428028.2SNCA, SQSTM1, CRYAB, DRD2

Products for genes affiliated with Multiple System Atrophy

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  • Antibodies
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Sources for Multiple System Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet