MCID: MLT021
MIFTS: 80

Multiple System Atrophy malady

Genetic diseases, Rare diseases, Neuronal diseases, Muscle diseases categories

Summaries for Multiple System Atrophy

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OMIM:47 Multiple system atrophy (MSA) is a distinct clinicopathologic entity that manifests as a progressive adult-onset... (146500) more...

MalaCards based summary: Multiple System Atrophy, also known as shy-drager syndrome, is related to spinal muscular atrophy and pure autonomic failure, and has symptoms including muscular hypotonia, reduced tendon reflexes and amyotrophy. An important gene associated with Multiple System Atrophy is COQ2 (coenzyme Q2 4-hydroxybenzoate polyprenyltransferase), and among its related pathways are Translational Control and Alpha-synuclein signaling. The compounds methylphenidate and reserpine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are taste/olfaction and skeleton.

NIH Rare Diseases:43 Multiple system atrophy (msa) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  msa affects both men and women primarily in their 50s.  the disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. the cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested. there is no cure for this condition, and there is no known way to prevent the disease from getting worse. the goal of treatment is to control symptoms.  last updated: 10/7/2010

NINDS:44 Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects both men and women primarily in their 50s.

Genetics Home Reference:23 Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.

Wikipedia:65 Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the... more...

Aliases & Classifications for Multiple System Atrophy

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Sources:
47OMIM, 32LifeMap Discovery®, 10Disease Ontology, 43NIH Rare Diseases, 23Genetics Home Reference, 44NINDS, 12DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 28ICD10 via Orphanet, 36MESH via Orphanet, 63UMLS via Orphanet
See all sources

Multiple System Atrophy, Aliases & Descriptions:

Name: Multiple System Atrophy 47 32 10 43 23 44 12 45 49 62
Shy-Drager Syndrome 10 23 44 62
Msa 43 23 49
Proximal Spinal Muscular Atrophy 43 49
Striatonigral Degeneration 23 62
 
Multisystem Atrophy 43 49
Sma 43 49
Autosomal Dominant Proximal Spinal Muscular Atrophy 43
Multi System Atrophy 62
Opca 23


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Muscle diseases


Characteristics (Orphanet epidemiological data):

49
proximal spinal muscular atrophy:
Inheritance: Autosomal recessive; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age
multiple system atrophy:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/100000 (Worldwide),1-5/10000 (Japan); Age of onset: Adult


External Ids:

OMIM47 146500
Disease Ontology10 DOID:4752
NCIt40 C85066
MeSH35 D012791
SNOMED-CT57 230297002, 16576004
Orphanet49 70, 102
ICD10 via Orphanet28 G12.0, G12.1, G90.3
MESH via Orphanet36 D019578
UMLS via Orphanet63 C0393571

Related Diseases for Multiple System Atrophy

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Diseases related to Multiple System Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1spinal muscular atrophy31.2GDNF, IGHMBP2, SMN1, CHAT
2pure autonomic failure31.2SNCA, MAOB
3olivopontocerebellar atrophy30.9TSPO, SNCA
4striatonigral degeneration30.9SNCA, RPS27A, DRD2, SLC6A3
5dementia30.7SLC6A3, LRRK2, GFAP, CHAT, TSPO, SNCA
6spinal muscular atrophy-130.6RPS27A, SMN1
7spinocerebellar ataxia30.6SNCA, RPS27A, MAPT, FMR1
8rem sleep behavior disorder30.5SNCA, SLC6A3
9machado-joseph disease30.4SNCA, RPS27A, SLC6A3
10lateral sclerosis30.4SNCA, MAPT
11essential tremor30.3LRRK2, SNCA, FMR1, SLC6A3
12motor neuron disease30.1GDNF, IGHMBP2, SMN1, SNCA, RPS27A, MAPT
13myositis30.1MAPT, RPS27A, SNCA
14tauopathy30.0MAPT, RPS27A, SNCA, LRRK2
15bipolar disorder30.0GDNF, TSPO, MAOB, DRD2, SLC6A3
16pick disease30.0CHAT, SNCA, RPS27A, MAPT, SQSTM1, CRYAB
17myotonic dystrophy30.0CRYAB, FMR1, MAPT, SMN1
18breast cancer29.9SNCA, RPS27A, MAPT, SQSTM1, CRYAB, DRD2
19alzheimer disease29.7GFAP, CHAT, TSPO, SNCA, SNCB, RPS27A
20muscular atrophy10.8
21neuronitis10.7
22striatonigral degeneration, infantile10.7
23ataxia10.6
24synucleinopathy10.6
25cerebritis10.6
26autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures10.5
27autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures10.5
28autosomal dominant childhood-onset proximal spinal muscular atrophy10.5
29multiple system atrophy with orthostatic hypotension10.5
30autonomic dysfunction10.5
31juvenile spinal muscular atrophy10.5
32adult-onset proximal spinal muscular atrophy, autosomal dominant10.4
33corticobasal degeneration10.4
34dysautonomia10.4
35cerebellar ataxia10.4
36sleep disorder10.4
37tremor10.4
38multiple system atrophy, cerebellar type10.4
39bullous pemphigoid10.4
40cerebellar degeneration10.4
41torsion dystonia10.4
42neuroleptic malignant syndrome10.3
43sporadic infantile bilateral striatal necrosis10.3
44spinal muscular atrophy-210.3
45werdnig-hoffman disease10.3
46apraxia10.3
47dystonia10.3
48respiratory failure10.3
49multiple system atrophy, parkinsonian type10.3
50spinal muscular atrophy, x-linked 2, infantile10.2

Graphical network of the top 20 diseases related to Multiple System Atrophy:



Diseases related to multiple system atrophy

Symptoms for Multiple System Atrophy

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Symptoms by clinical synopsis from OMIM:

146500

Clinical features from OMIM:

146500

Symptoms:

 49 (show all 17)
  • movement disorder
  • hypotonia
  • areflexia/hyporeflexia
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • autosomal recessive inheritance
  • preauricular/branchial tags/appendages
  • rib number anomalies
  • abnormal cry/voice/phonation disorder/nasal speech
  • lymphedema
  • mutiple fractures/bone fragility
  • restricted joint mobility/joint stiffness/ankylosis
  • stillbirth/neonatal death
  • polyhydramnios
  • intrauterine growth retardation

HPO human phenotypes related to Multiple System Atrophy:

(show all 44)
id Description Frequency HPO Source Accession
1 muscular hypotonia hallmark (90%) HP:0001252
2 reduced tendon reflexes hallmark (90%) HP:0001315
3 amyotrophy hallmark (90%) HP:0003202
4 emg abnormality hallmark (90%) HP:0003457
5 hemiplegia/hemiparesis hallmark (90%) HP:0004374
6 abnormality of movement hallmark (90%) HP:0100022
7 preauricular skin tag typical (50%) HP:0000384
8 abnormality of the ribs typical (50%) HP:0000772
9 lymphedema typical (50%) HP:0001004
10 limitation of joint mobility typical (50%) HP:0001376
11 intrauterine growth retardation typical (50%) HP:0001511
12 polyhydramnios typical (50%) HP:0001561
13 abnormality of the voice typical (50%) HP:0001608
14 recurrent fractures typical (50%) HP:0002757
15 cognitive impairment rare (5%) HP:0100543
16 autosomal dominant inheritance HP:0000006
17 autosomal recessive inheritance HP:0000007
18 urinary urgency HP:0000012
19 urinary incontinence HP:0000020
20 ptosis HP:0000508
21 gaze-evoked nystagmus HP:0000640
22 impotence HP:0000802
23 hypohidrosis HP:0000966
24 anhidrosis HP:0000970
25 iris atrophy HP:0001089
26 ataxia HP:0001251
27 dysarthria HP:0001260
28 orthostatic hypotension HP:0001278
29 parkinsonism HP:0001300
30 tremor HP:0001337
31 hyperreflexia HP:0001347
32 abnormality of metabolism/homeostasis HP:0001939
33 rigidity HP:0002063
34 bradykinesia HP:0002067
35 postural instability HP:0002172
36 neurodegeneration HP:0002180
37 dysautonomia HP:0002459
38 olivopontocerebellar atrophy HP:0002542
39 amyotrophy HP:0003202
40 babinski sign HP:0003487
41 adult onset HP:0003581
42 progressive disorder HP:0003676
43 sporadic HP:0003745
44 phenotypic variability HP:0003812

Drugs & Therapeutics for Multiple System Atrophy

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Drug clinical trials:

Search ClinicalTrials for Multiple System Atrophy

Search NIH Clinical Center for Multiple System Atrophy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple System Atrophy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple System Atrophy:
Mesenchymal stem cells for multiple system atrophy
Embryonic/Adult Cultured Cells Related to Multiple System Atrophy:
Bone marrow-derived mesenchymal stem cells, PMID: 19513327

Genetic Tests for Multiple System Atrophy

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Anatomical Context for Multiple System Atrophy

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MalaCards organs/tissues related to Multiple System Atrophy:

33
Brain, Bone, Bone marrow, Testes, Skin, Eye, Cortex, Heart, Colon, Whole blood, Cerebellum, Skeletal muscle, Temporal lobe, Olfactory bulb, Subthalamic nucleus, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple System Atrophy:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Multiple System Atrophy or affiliated genes

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Publications for Multiple System Atrophy

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Articles related to Multiple System Atrophy:

(show top 50)    (show all 720)
idTitleAuthorsYear
1
Update on novel familial forms of Parkinson's disease and multiple system atrophy. (24262183)
2014
2
XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. (23993308)
2014
3
The basal ganglia in perceptual timing: Timing performance in Multiple System Atrophy and Huntington's disease. (24135486)
2014
4
Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins. (23948991)
2013
5
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. (24243499)
2013
6
Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. (22806758)
2012
7
The neuropathology, pathophysiology and genetics of multiple system atrophy. (22074330)
2012
8
"Hot cross bun" sign in multiple system atrophy with predominant cerebellar ataxia: a comparison between proton density-weighted imaging and T2-weighted imaging. (22209432)
2012
9
Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease. (22371705)
2012
10
Post mortem cerebrospinal fluid I+-synuclein levels are raised in multiple system atrophy and distinguish this from the other I+-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. (21856424)
2012
11
Serum urate levels are not associated with survival in multiple system atrophy. (21354851)
2011
12
Uric acid as a potential disease modifier in patients with multiple system atrophy. (21542015)
2011
13
Diagnostic performance of iodine-123-metaiodobenzylguanidine scintigraphy in differential diagnosis between Parkinson's disease and multiple-system atrophy: a systematic review and a meta-analysis. (21962800)
2011
14
Genetic players in multiple system atrophy: unfolding the nature of the beast. (21601954)
2011
15
A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. (20176003)
2010
16
Role of TPPP/p25 on I+-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy. (20849899)
2010
17
Multiple-system atrophy presenting with low rectal compliance and bowel pain. (20629156)
2010
18
Whole body and cardiac metaiodobenzylguanidine kinetics in Parkinson disease and multiple system atrophy: implications for the diagnostic role of imaging. (20395701)
2010
19
White matter hyperintensities in patients with multiple system atrophy. (19468782)
2009
20
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy. (19514077)
2009
21
Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death. (19429902)
2009
22
A validation exercise on the new consensus criteria for multiple system atrophy. (19845011)
2009
23
Multiple system atrophy: a primary oligodendrogliopathy. (18825660)
2008
24
Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy. (18178568)
2008
25
Loss of A5 noradrenergic neurons in multiple system atrophy. (18297292)
2008
26
PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease. (18236005)
2008
27
Multiple system atrophy: alpha-synuclein and neuronal degeneration. (18018485)
2007
28
Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy. (17139443)
2007
29
Abnormal temporal discrimination threshold in patients with multiple system atrophy. (17260339)
2007
30
Paradoxical vocal cord motion: a review focused on multiple system atrophy. (17482397)
2007
31
Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy. (17235127)
2007
32
Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy. (17544807)
2007
33
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. (18018479)
2007
34
Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy. (17291816)
2007
35
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. (17485650)
2007
36
Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. (17562934)
2007
37
Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy. (17603243)
2007
38
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
39
Hyperintensity of the middle cerebellar peduncles on fluid-attenuated inversion recovery imaging: variation with age and implications for the diagnosis of multiple system atrophy. (17110685)
2006
40
CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia. (16894110)
2006
41
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). (15583958)
2005
42
Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy. Case report. (15035294)
2004
43
Involvement of medullary serotonergic groups in multiple system atrophy. (14991820)
2004
44
Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy). (12764627)
2003
45
Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy. (14639688)
2003
46
The pathogenesis of multiple system atrophy: past, present, and future. (11009180)
2000
47
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease. (9452329)
1998
48
Olivopontocerebellar atrophy and multiple system atrophy: clinical follow-up of 10 patients studied with PET. (9667610)
1998
49
A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy. (7876880)
1995
50
Whole blood monoamine oxidase activity in Parkinson's disease and multiple system atrophy patients. (8410065)
1993

Variations for Multiple System Atrophy

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UniProtKB/Swiss-Prot genetic disease variations for Multiple System Atrophy:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1COQ2p.Phe29LeuVAR_070239
2COQ2p.Pro49HisVAR_070240
3COQ2p.Ser57ThrVAR_070241
4COQ2p.Met78ValVAR_070243
5COQ2p.Ile97ThrVAR_070244
6COQ2p.Pro107SerVAR_070245
7COQ2p.Ser113PheVAR_070246
8COQ2p.Thr267AlaVAR_070247
9COQ2p.Ser297CysVAR_070248
10COQ2p.Arg337GlnVAR_070250
11COQ2p.Val343AlaVAR_070251

Clinvar genetic disease variations for Multiple System Atrophy:

7 (show all 26)
id Gene Variation Type Significance SNP ID Assembly Location
1COQ2COQ2, MET78VALundetermined variantrisk factor
2COQ2NM_015697.7(COQ2): c.1028T> C (p.Val343Ala)single nucleotide variantrisk factorrs397514727GRCh37Chr 4, 84188812: 84188812
3COQ2COQ2, ARG337TERundetermined variantrisk factor
4COQ2COQ2, ARG337GLNundetermined variantrisk factor
5IGHMBP2NM_002180.2(IGHMBP2): c.1540G> A (p.Glu514Lys)single nucleotide variantPathogenicrs137852665GRCh37Chr 11, 68701934: 68701934
6IGHMBP2NM_002180.2(IGHMBP2): c.638A> G (p.His213Arg)single nucleotide variantPathogenicrs137852666GRCh37Chr 11, 68678998: 68678998
7IGHMBP2NM_002180.2(IGHMBP2): c.1738G> A (p.Val580Ile)single nucleotide variantPathogenicrs137852667GRCh37Chr 11, 68702872: 68702872
8IGHMBP2NM_002180.2(IGHMBP2): c.121C> T (p.Gln41Ter)single nucleotide variantPathogenicrs137852668GRCh37Chr 11, 68673571: 68673571
9IGHMBP2IGHMBP2, 1-BP DEL, 675TdeletionPathogenic
10IGHMBP2NM_002180.2(IGHMBP2): c.707T> G (p.Leu236Ter)single nucleotide variantPathogenicrs137852669GRCh37Chr 11, 68679067: 68679067
11IGHMBP2IGHMBP2, IVS13, G-T, +1single nucleotide variantPathogenic
12IGHMBP2NM_002180.2(IGHMBP2): c.1107C> G (p.Phe369Leu)single nucleotide variantPathogenicrs137852670GRCh37Chr 11, 68696697: 68696697
13IGHMBP2IGHMBP2, 18.5-KB DEL, EX3-7deletionPathogenic
14SMN1SMN1, 11-BP DUP, 801-811duplicationPathogenic
15SMN1NM_000344.3(SMN1): c.821C> T (p.Thr274Ile)single nucleotide variantPathogenicrs76871093GRCh37Chr 5, 70241990: 70241990
16SMN1NM_000344.3(SMN1): c.815A> G (p.Tyr272Cys)single nucleotide variantPathogenicrs104893922GRCh37Chr 5, 70241984: 70241984
17SMN1NM_000344.3(SMN1): c.836G> T (p.Gly279Val)single nucleotide variantPathogenicrs76163360GRCh37Chr 5, 70247769: 70247769
18SMN1NM_000344.3(SMN1): c.5C> G (p.Ala2Gly)single nucleotide variantPathogenicrs75030631GRCh37Chr 5, 70220935: 70220935
19SMN1SMN1, EX8DELdeletionPathogenic
20SMN1SMN1, 5-BP DEL, 425deletionPathogenic
21SMN1NM_000344.3(SMN1): c.305G> A (p.Trp102Ter)single nucleotide variantPathogenicrs77804083GRCh37Chr 5, 70238216: 70238216
22SMN1SMN1, 4-BP DEL, 399AGAGdeletionPathogenic
23SMN1NM_000344.3(SMN1): c.88G> A (p.Asp30Asn)single nucleotide variantPathogenicrs104893930GRCh37Chr 5, 70234672: 70234672
24SMN1NM_000344.3(SMN1): c.332C> G (p.Ala111Gly)single nucleotide variantPathogenicrs104893935GRCh37Chr 5, 70238243: 70238243
25SMN1NM_000344.3(SMN1): c.346A> T (p.Ile116Phe)single nucleotide variantPathogenicrs104893933GRCh37Chr 5, 70238257: 70238257
26SMN1NM_000344.3(SMN1): c.406C> G (p.Gln136Glu)single nucleotide variantPathogenicrs104893934GRCh37Chr 5, 70238317: 70238317

Expression for genes affiliated with Multiple System Atrophy

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Search GEO for disease gene expression data for Multiple System Atrophy.

Pathways for genes affiliated with Multiple System Atrophy

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Pathways related to Multiple System Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SMN1, FMR1, SQSTM1
29.5SNCA, MAOB, SLC6A3
39.4SLC6A3, SNCA, LRRK2
4
Show member pathways
9.4SLC6A3, DRD2, MAOB
5
Show member pathways
9.2SLC6A3, DRD2, MAOB, SNCA
6
Show member pathways
9.1SLC6A3, DRD2, SNCA, LRRK2
7
Show member pathways
9.0CHAT, MAOB, DRD2, SLC6A3
8
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.8SLC6A3, MAPT, RPS27A, SNCA
97.8FMR1, MAPT, SNCB, SNCA, GFAP, LRRK2

Compounds for genes affiliated with Multiple System Atrophy

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Compounds related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1methylphenidate45 51 1311.7DRD2, SLC6A3, MAOB
2reserpine45 30 1311.7MAOB, DRD2, SLC6A3
3maoa459.7SLC6A3, MAOB, DRD2
4thioflavine s459.5MAPT, RPS27A, SNCA
51 methyl 4 phenylpyridinium459.5GDNF, SNCA, SLC6A3, MAOB
6selegiline45 1310.5SLC6A3, MAOB, SNCA, GDNF
7heroin45 51 1311.4SLC6A3, CHAT, DRD2
8d amphetamine459.3DRD2, MAOB, TSPO, SLC6A3
9homovanillic acid45 2610.3GFAP, CHAT, MAOB
10l-amino acid459.2MAOB, CHAT, GDNF
11catecholamine459.2MAOB, SNCA, CHAT, GDNF
12rotenone459.1SLC6A3, MAOB, RPS27A, SNCA, TSPO
13amphetamine45 51 1311.1GDNF, SNCA, MAOB, DRD2, SLC6A3
14benzodiazepine459.1TSPO, CHAT, GFAP
154-hydroxynonenal45 2610.0SNCA, RPS27A, CHAT, MAPT
16haloperidol45 51 30 3 1312.9TSPO, SLC6A3, DRD2, CHAT, MAOB
17formate458.9MAPT, RPS27A, GFAP, SNCA
18apomorphine30 45 1310.8SLC6A3, MAOB, DRD2, SNCA, CHAT, GDNF
19morphine45 51 30 1311.8TSPO, GFAP, DRD2, SLC6A3
20valine458.6SNCA, SLC6A3, TSPO, RPS27A, MAPT
21methamphetamine45 51 1310.4SLC6A3, MAOB, SNCA, GFAP, RPS27A, DRD2
22silver458.3RPS27A, SNCA, CHAT, MAPT, FMR1, GFAP
235-hydroxytryptamine458.3SLC6A3, MAOB, CHAT, TSPO, DRD2, GFAP
24butyrate458.3SMN1, GFAP, CHAT, MAPT, FMR1, RPS27A
25paraffin458.2GFAP, MAPT, CRYAB, RPS27A, CHAT, SNCA
26nicotine45 30 51 1311.1MAPT, MAOB, TSPO, CHAT, DRD2, SLC6A3
27kainate45 309.0GFAP, TSPO, CHAT, GDNF, MAPT
28glutamine458.0SNCA, GFAP, CRYAB, MAPT, RPS27A, TSPO
29norepinephrine45 26 139.9SLC6A3, DRD2, MAOB, SNCA, TSPO, GDNF
306-hydroxydopamine457.9SNCA, DRD2, GDNF, GFAP, CHAT, RPS27A
31spec-t457.9TSPO, GFAP, SLC6A3, MAOB, MAPT, DRD2
32levodopa45 138.9SLC6A3, DRD2, MAOB, RPS27A, SNCA, TSPO
33glycogen45 268.8GFAP, CHAT, MAPT, SNCA, RPS27A
34mptp457.8DRD2, MAOB, RPS27A, SNCA, TSPO, GFAP
35aspartate457.7RPS27A, CRYAB, CHAT, SLC6A3, GFAP, GDNF
36testosterone45 61 26 1310.7SNCA, MAPT, RPS27A, TSPO, CHAT, GFAP
37choline45 26 139.7SLC6A3, MAPT, SNCA, MAOB, GDNF, GFAP
38alanine457.7SNCA, SLC6A3, MAPT, RPS27A, CHAT, GFAP
39cocaine45 138.7GDNF, GFAP, CHAT, TSPO, SNCA, MAOB
40arginine457.6RPS27A, MAPT, SLC6A3, SNCA, TSPO, GFAP
41cysteine457.5SLC6A3, MAPT, RPS27A, GDNF, MAOB, GFAP
42h2o2457.4SNCA, SNCB, MAOB, GDNF, MAPT, CRYAB
43gaba457.4MAOB, TSPO, FMR1, GDNF, GFAP, CHAT
44creatinine457.2MAPT, MAOB, RPS27A, TSPO, GFAP, FMR1
45estrogen457.2RPS27A, MAPT, TSPO, CHAT, GFAP, GDNF
46serine457.0GDNF, GFAP, RPS27A, MAOB, MAPT, SQSTM1
47acetylcholine45 51 30 26 1311.0GFAP, DRD2, RPS27A, SLC6A3, MAPT, SNCA
48nmda45 307.8MAPT, GDNF, GFAP, CHAT, SLC6A3, DRD2
49glutamate456.3SNCA, RPS27A, MAOB, CHAT, MAPT, TSPO
50dopamine45 30 26 139.0DRD2, MAPT, TSPO, GFAP, LRRK2, GDNF

GO Terms for genes affiliated with Multiple System Atrophy

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Cellular components related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:00162349.7SNCA, LRRK2
2growth coneGO:00304269.0IGHMBP2, SNCA, SNCB, MAPT
3neuronal cell bodyGO:00430258.9LRRK2, CHAT, SNCB, SLC6A3
4mitochondrionGO:00057397.8LRRK2, CHAT, TSPO, SNCA, SNCB, COQ2
5axonGO:00304247.8SLC6A3, IGHMBP2, LRRK2, CHAT, SNCA, MAPT
6cytosolGO:00058296.7LRRK2, GFAP, CHAT, SNCA, RPS27A, MAPT
7cytoplasmGO:00057376.7IGHMBP2, LRRK2, NUB1, GFAP, CHAT, TSPO

Biological processes related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1dopamine biosynthetic processGO:004241610.2SNCA, SLC6A3
2dopamine metabolic processGO:004241710.2SNCB, DRD2
3behavioral response to cocaineGO:004814810.2DRD2, SNCA
4adenohypophysis developmentGO:002198410.1SLC6A3, DRD2
5response to interferon-gammaGO:003434110.1SNCA, NUB1
6response to iron ionGO:001003910.1SLC6A3, DRD2
7prepulse inhibitionGO:006013410.1DRD2, SLC6A3
8regulation of long-term neuronal synaptic plasticityGO:004816910.0DRD2, SNCA
9regulation of locomotionGO:004001210.0LRRK2, SNCA
10regulation of dopamine uptake involved in synaptic transmissionGO:005158410.0DRD2, GDNF
11neurotransmitter biosynthetic processGO:004213610.0SLC6A3, CHAT
12peristalsisGO:003043210.0DRD2, GDNF
13response to cocaineGO:00422209.8DRD2, SLC6A3
14cell deathGO:00082199.8SLC6A3, COQ2, IGHMBP2
15negative regulation of neuron apoptotic processGO:00435249.8SNCB, SNCA, GDNF
16response to nicotineGO:00350949.7SLC6A3, DRD2
17negative regulation of intracellular transportGO:00323879.7CRYAB, MAPT
18synapse organizationGO:00508089.7SNCB, SNCA
19long-term synaptic potentiationGO:00602919.7SNCA, GFAP
20agingGO:00075689.5TSPO, SNCA, CRYAB, SLC6A3
21adult walking behaviorGO:00076289.3DRD2, MAPT, CHAT
22negative regulation of apoptotic processGO:00430669.3GDNF, SNCA, RPS27A, SQSTM1, CRYAB
23synaptic transmissionGO:00072689.2CHAT, TSPO, SNCB, SLC6A3
24response to drugGO:00424939.0SLC6A3, DRD2, MAOB, SNCA, TSPO

Molecular functions related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.8SLC6A3, DRD2
2alpha-tubulin bindingGO:00430149.7SNCB, SNCA
3microtubule bindingGO:00080179.1SNCA, MAPT, CRYAB
4identical protein bindingGO:00428028.9LRRK2, SNCA, SQSTM1, CRYAB, DRD2
5protein homodimerization activityGO:00428038.3DRD2, CRYAB, SQSTM1, MAOB, LRRK2, GDNF
6protein bindingGO:00055157.0LRRK2, NUB1, SNCA, MAPT, FMR1, SQSTM1

Products for genes affiliated with Multiple System Atrophy

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  • Antibodies
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  • Kits and Assays

Sources for Multiple System Atrophy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet