MSA
MCID: MLT021
MIFTS: 64

Multiple System Atrophy (MSA) malady

Neuronal category

Summaries for Multiple System Atrophy

Sources:
43NIH Rare Diseases, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Multiple system atrophy (msa) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  msa affects both men and women primarily in their 50s.  the disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. the cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested. there is no cure for this condition, and there is no known way to prevent the disease from getting worse. the goal of treatment is to control symptoms.  last updated: 10/7/2010

MalaCards: Multiple System Atrophy, also known as shy-drager syndrome, is related to parkinson's disease and progressive supranuclear palsy. An important gene associated with Multiple System Atrophy is COQ2 (coenzyme Q2 4-hydroxybenzoate polyprenyltransferase), and among its related pathways are Neuroscience and Alpha-synuclein signaling. The compounds dopamine and glutamate have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

NINDS:44 Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects both men and women primarily in their 50s.

Genetics Home Reference:21 Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.

Wikipedia:64 Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the... more...

Description from OMIM:47 146500

Aliases & Classifications for Multiple System Atrophy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
multiple system atrophy:
Inheritance: Autosomal recessive,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood
shy-drager syndrome:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

multiple system atrophy 8 43 21 44 47 10 45 49 31 61
shy-drager syndrome 8 21 44 49 61
msa 43 21 49
striatonigral degeneration 21 61
multiple system atrophy - urinary dysfunction 49
msa - urinary dysfunction 49
multisystem atrophy 49
opca 21
sds 49


External Ids:

Disease Ontology8 DOID:4752
MeSH35 D012791
OMIM47 146500
NCIt40 C85066
SNOMED-CT57 16576004, 230297002
MESH via Orphanet36 D019578, D012791
ICD10 via Orphanet26 G90.3
SNOMED-CT via Orphanet58 230297002, 16576004
UMLS via Orphanet62 C0393571, C0037019

Related Diseases for Multiple System Atrophy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Multiple System Atrophy family:

multiple system atrophy with orthostatic hypotension

Diseases related to Multiple System Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.6RPS27A, DRD2, SNCB, SNCG, SNCA, MAOB
2progressive supranuclear palsy31.3MAPT, SLC6A3
3pure autonomic failure31.1SNCA, DBH
4olivopontocerebellar atrophy30.9SNCA, TSPO
5striatonigral degeneration30.9RPS27A, DRD2, SNCA, SLC6A3
6brain disease30.8SNCA, CHAT, MAPT, SERPINA3, TSPO
7alzheimer's disease30.7RPS27A, TSPO, SERPINA3, PVALB, DRD2, SQSTM1
8spinocerebellar ataxia30.7RPS27A, FMR1, SNCA, MAPT
9dysautonomia30.6SNCA, DBH
10lewy body dementia30.4SNCA, SNCB
11amyotrophic lateral sclerosis30.2RPS27A, PVALB, SQSTM1, CRYAB, SNCA, CHAT
12pick's disease30.2RPS27A, SQSTM1, CRYAB, SNCA, CHAT, MAPT
13huntington's disease30.2DRD2, CHAT
14essential tremor30.2FMR1, SNCA, LRRK2, SLC6A3
15lateral sclerosis30.2SNCA, MAPT
16semantic dementia30.0MAPT, RPS27A
17cadasil30.0PVALB, CHAT, MAOB, MAPT, GDNF, SERPINA3
18bipolar disorder30.0PVALB, DRD2, MAOB, DBH, GDNF, SLC6A3
19cocaine dependence29.8DRD2, DBH, SLC6A3
20primary progressive aphasia29.8RPS27A, MAPT
21ataxia10.6
22cerebral atrophy10.6
23multiple system atrophy, cerebellar type10.6
24sleep disorder10.5
25autonomic dysfunction10.5
26multiple system atrophy with orthostatic hypotension10.5
27striatonigral degeneration infantile10.5
28spinocerebellar atrophy10.5
29corticobasal degeneration10.4
30multiple system atrophy, parkinsonian type10.4
31shwachman-diamond syndrome10.4
32skin atrophy10.4
33tremor10.4
34parkinson disease 110.4
35parkinson disease 1210.4
36hemoglobin d disease10.3
37bullous pemphigoid10.3
38torsion dystonia10.3
39neuroleptic malignant syndrome10.3
40hemoglobin c disease10.3
41machado-joseph disease10.3
42apraxia10.3
43blepharospasm10.2
44basal ganglia disease10.2
45progressive supranuclear palsy atypical10.2
46dysphagia10.2
47postural hypotension10.2
48muscular atrophy10.2
49spinal muscular atrophy10.2
50spinocerebellar ataxia type 710.2

Graphical network of the top 20 diseases related to Multiple System Atrophy:



Diseases related to multiple system atrophy

Clinical Features for Multiple System Atrophy

Sources:
47OMIM
See all sources

Clinical features from OMIM:

146500

Clinical synopsis from OMIM:

146500

Drugs & Therapeutics for Multiple System Atrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple System Atrophy

Drug clinical trials:

Search ClinicalTrials for Multiple System Atrophy

Search NIH Clinical Center for Multiple System Atrophy

Search CenterWatch for Multiple System Atrophy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple System Atrophy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple System Atrophy:
Mesenchymal stem cells for multiple system atrophy
Embryonic/Adult Cultured Cells Related to Multiple System Atrophy:
Bone marrow-derived mesenchymal stem cells, PMID: 19513327

Genetic Tests for Multiple System Atrophy

Anatomical Context for Multiple System Atrophy

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple System Atrophy:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Multiple System Atrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Multiple System Atrophy

Sources:
51PubMed
See all sources

Articles related to Multiple System Atrophy:

(show top 50)    (show all 679)
idTitleAuthorsYear
1
XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. (23993308)
2014
2
Primary motor cortex long-term plasticity in multiple system atrophy. (24114982)
2014
3
Decreased retinal sensitivity and loss of retinal nerve fibers in multiple system atrophy. (22878471)
2013
4
A randomized clinical trial of lithium in multiple system atrophy. (22932748)
2013
5
Multiple compulsive behaviors in multiple system atrophy: The importance of predisposition to addiction. (24423790)
2013
6
Force control deficits in individuals with Parkinson's disease, multiple systems atrophy, and progressive supranuclear palsy. (23505500)
2013
7
Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2. (22605703)
2012
8
Animal models of multiple system atrophy. (21963351)
2012
9
Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging. (22051807)
2012
10
Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the (13)C-acetate breath test. (22218651)
2012
11
Tau-positive glial cytoplasmic granules in multiple system atrophy. (21062361)
2011
12
Progression of striatal and extrastriatal degeneration in multiple system atrophy: a longitudinal diffusion-weighted MR study. (21469200)
2011
13
A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. (20176003)
2010
14
Basal ganglia cellular pathology in multiple system atrophy, progressive supranuclear palsy and Parkinson disease. Can quantitative magnetic resonance spectroscopic imaging make the difference? (20561041)
2010
15
Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system. (20683839)
2010
16
Papp-Lantos inclusions and the pathogenesis of multiple system atrophy: an update. (20309568)
2010
17
Microstructural white matter abnormalities of multiple system atrophy: in vivo topographic illustration by using diffusion-tensor MR imaging. (20413765)
2010
18
Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy. (20515677)
2010
19
Neuromuscular junctions of the posterior cricoarytenoid muscle in multiple system atrophy: a case study. (19848253)
2009
20
Dermal sheet preparations in the evaluation of dermal innervation in Parkinson's disease and multiple system atrophy. (18727665)
2009
21
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. (19935145)
2009
22
Clinical speech impairment in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy. (18688134)
2008
23
CSF hypocretin-1 levels are normal in multiple-system atrophy. (17977056)
2008
24
Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. (18808062)
2008
25
Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease. (18544255)
2008
26
Multiple system atrophy: alpha-synuclein and neuronal degeneration. (18018485)
2007
27
Hallucinations in multiple system atrophy. (17049296)
2007
28
Potential outcome measures and trial design issues for multiple system atrophy. (17914727)
2007
29
Disproportionate antecollis: a warning sign for multiple system atrophy. (17659640)
2007
30
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease. (17237936)
2007
31
Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report]. (16585892)
2006
32
False-positive SCA8 gene test in a patient with pathologically proven multiple system atrophy. (15732096)
2005
33
Growth hormone response to arginine test distinguishes multiple system atrophy from Parkinson's disease and idiopathic late-onset cerebellar ataxia. (15807873)
2005
34
Alpha-1-antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA). (15907346)
2005
35
Involvement of medullary serotonergic groups in multiple system atrophy. (14991820)
2004
36
Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy). (15056471)
2004
37
Differentiation of idiopathic Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging. (14741660)
2004
38
Fragile X gene premutation in multiple system atrophy. (15546601)
2004
39
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. (12811584)
2003
40
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. (12875980)
2003
41
The cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failure. (11605821)
2001
42
Assessment of cardiovascular autonomic dysfunction in multiple system atrophy. (11503950)
2001
43
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. (11307630)
2001
44
Severe dysphagia after botulinum toxin injection for cervical dystonia in multiple system atrophy. (11481708)
2001
45
Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy. (11595348)
2001
46
The pathogenesis of multiple system atrophy: past, present, and future. (11009180)
2000
47
Asymmetrical temporal lobe atrophy with massive neuronal inclusions in multiple system atrophy. (11054485)
2000
48
Separating the primary autonomic failure syndromes, multiple system atrophy, and pure autonomic failure from Parkinson's disease. (10410741)
1999
49
REM sleep behaviour disorder differentiates pure autonomic failure from multiple system atrophy with autonomic failure. (9598693)
1998
50
Whole blood monoamine oxidase activity in Parkinson's disease and multiple system atrophy patients. (8410065)
1993

Genetic Variations for Multiple System Atrophy

Expression for genes affiliated with Multiple System Atrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Multiple System Atrophy

Search GEO for disease gene expression data for Multiple System Atrophy.

Pathways for genes affiliated with Multiple System Atrophy

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Multiple System Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5LRRK2, DBH, MAPT, SNCA, SNCB, FMR1
210.5SNCA, MAOB, SLC6A3
3
Hide members
10.5SLC6A3, MAOB, DRD2
410.5SLC6A3, LRRK2, SNCA

Compounds for genes affiliated with Multiple System Atrophy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2414.0RPS27A, PVALB, DRD2, MAOB, MAPT, DBH
2glutamate4511.0DBH, GDNF, SLC6A3, TSPO, CHAT, MAPT
3levodopa45 1112.0TSPO, SLC6A3, RPS27A, DRD2, SNCA, MAOB
4acetylcholine45 50 29 11 2415.0TSPO, SERPINA3, RPS27A, SLC6A3, GDNF, DBH
5mptp4511.0RPS27A, DRD2, SNCA, TSPO, SLC6A3, GDNF
66-hydroxydopamine4511.0RPS27A, DRD2, SNCA, MAOB, DBH, GDNF
7gaba4511.0GDNF, DBH, SLC6A3, MAOB, CHAT, DRD2
8cocaine45 1112.0DBH, MAOB, SLC6A3, TSPO, CHAT, GDNF
9methamphetamine45 50 1113.0MAOB, RPS27A, PVALB, DRD2, SNCA, CHAT
10h2o24511.0SLC6A3, DBH, MAPT, MAOB, SNCB, CRYAB
11norepinephrine45 11 2413.0TSPO, SLC6A3, GDNF, DBH, MAOB, CHAT
12choline45 11 2412.9PVALB, SNCA, CHAT, MAOB, MAPT, SLC6A3
13apomorphine45 29 1112.9DRD2, SNCA, GDNF, MAOB, SLC6A3, CHAT
14nmda45 2911.9RPS27A, PVALB, CHAT, MAPT, MAOB, TSPO
15silver4510.9FMR1, RPS27A, PVALB, SERPINA3, MAPT, CHAT
16nicotine45 50 29 1113.9DRD2, CHAT, MAOB, MAPT, DBH, TSPO
17haloperidol45 29 2 50 1114.9DRD2, TSPO, CHAT, MAOB, SLC6A3, PVALB
18d amphetamine4510.9MAOB, TSPO, SLC6A3, DRD2
19spec-t4510.9MAPT, DRD2, MAOB, SLC6A3, TSPO
20rotenone4510.9SLC6A3, MAOB, SNCA, TSPO, RPS27A
21amphetamine45 1111.9MAOB, SNCA, DRD2, GDNF, SLC6A3
225-hydroxytryptamine4510.9MAOB, TSPO, CHAT, DRD2, DBH, SLC6A3
23creatinine4510.9FMR1, SLC6A3, TSPO, RPS27A, SERPINA3, MAOB
24maoa4510.9SLC6A3, DRD2, MAOB, DBH
25valine4510.9TSPO, SERPINA3, SLC6A3, MAPT, SNCA, RPS27A
261 methyl 4 phenylpyridinium4510.9SLC6A3, GDNF, MAOB, SNCA
27paraffin4510.9CRYAB, SNCA, CHAT, RPS27A, MAPT, PVALB
28selegiline45 1111.9MAOB, GDNF, SLC6A3, SNCA
29alpha-methyl-p-tyrosine4510.8DBH, SLC6A3, DRD2
30estrogen4510.8PVALB, SNCG, CHAT, MAOB
31thioflavine s4510.8MAPT, SNCA, RPS27A
32l-amino acid4510.8MAOB, GDNF, CHAT, DBH
33iron45 2411.8PVALB, SERPINA3, GDNF, DBH, SNCA, SNCG
34catecholamine4510.8GDNF, SNCA, DBH, MAOB, CHAT
35kainate45 2911.8GDNF, MAPT, CHAT, PVALB, TSPO
36aspartate4510.8SLC6A3, GDNF, MAPT, CHAT, CRYAB, RPS27A
37serine4510.8MAOB, DBH, MAPT, SNCA, SQSTM1, PVALB
38alanine4510.8SERPINA3, SNCA, RPS27A, CHAT, DBH, GDNF
39formaldehyde45 2411.7PVALB, CHAT, RPS27A, DBH, MAPT
40carbidopa45 2911.7SLC6A3, DBH, MAOB
41imipramine45 50 29 11 2414.7SLC6A3, CHAT, MAOB, DBH
42cysteine4510.7SERPINA3, SLC6A3, GDNF, DBH, MAPT, MAOB
43dopac4510.7MAOB, GDNF, DBH
44guanidine hydrochloride4510.6SERPINA3, SNCA, MAOB, RPS27A
45opiate4510.6DRD2, DBH, SLC6A3, TSPO
46mhpg4510.6MAOB, DBH, SERPINA3
47superoxide45 2411.5CRYAB, SNCB, MAOB, GDNF, SERPINA3, DBH
48nadph45 2411.5DBH, PVALB, SERPINA3, SQSTM1, CHAT, MAPT
49methylphenidate45 50 1112.4DRD2, SLC6A3, MAOB
50reserpine45 29 1112.2MAOB, SLC6A3, DRD2

GO Terms for genes affiliated with Multiple System Atrophy

Sources:
16Gene Ontology
See all sources

Cellular components related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:03042610.5SNCB, MAPT, SNCA
2axonGO:03042410.4SLC6A3, MAPT, CHAT, SNCA, DRD2, PVALB
3neuronal cell bodyGO:04302510.2SNCG, CHAT, LRRK2, SLC6A3, SNCB

Biological processes related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249310.9TSPO, SLC6A3, MAOB, SNCA, SNCG, DRD2
2agingGO:00756810.9TSPO, SLC6A3, SNCA, CRYAB
3regulation of dopamine secretionGO:01405910.9DRD2, SNCG, SNCA
4response to cocaineGO:04222010.8SLC6A3, SNCG, DRD2
5synapse organizationGO:05080810.8SNCB, SNCG, SNCA
6adult walking behaviorGO:00762810.8MAPT, CHAT, DRD2
7adult locomotory behaviorGO:00834410.8SNCG, SNCA, GDNF
8regulation of dopamine uptake involved in synaptic transmissionGO:05158410.8DRD2, GDNF
9dopamine catabolic processGO:04242010.8DBH, SLC6A3
10synaptic transmissionGO:00726810.8SNCB, SNCG, CHAT, DBH, SLC6A3
11negative regulation of intracellular transportGO:03238710.8CRYAB, MAPT
12regulation of locomotionGO:04001210.8LRRK2, SNCA
13adenohypophysis developmentGO:02198410.8SLC6A3, DRD2
14behavioral response to ethanolGO:04814910.7DRD2, DBH
15negative regulation of apoptotic processGO:04306610.7GDNF, SNCA, CRYAB, SQSTM1, RPS27A
16peristalsisGO:03043210.7DRD2, GDNF
17locomotory behaviorGO:00762610.7DRD2, DBH, SLC6A3
18dopamine biosynthetic processGO:04241610.6SLC6A3, SNCA
19dopamine metabolic processGO:04241710.6SNCB, DRD2
20behavioral response to cocaineGO:04814810.6DRD2, SNCA
21response to iron ionGO:01003910.5DRD2, SLC6A3
22neurotransmitter biosynthetic processGO:04213610.5SLC6A3, CHAT
23prepulse inhibitionGO:06013410.4SLC6A3, DRD2
24negative regulation of neuron apoptotic processGO:04352410.2GDNF, SNCA, SNCB

Molecular functions related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alpha-tubulin bindingGO:04301410.6SNCA, SNCG, SNCB
2protein homodimerization activityGO:04280310.5SQSTM1, CRYAB, GDNF, LRRK2, MAOB
3beta-tubulin bindingGO:04848710.5SNCA, SNCB, SNCG
4identical protein bindingGO:04280210.4CRYAB, DRD2, SNCA, LRRK2, SQSTM1
5dopamine bindingGO:03524010.2SLC6A3, DRD2

Products for genes affiliated with Multiple System Atrophy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Multiple System Atrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet