MSA
MCID: MLT021
MIFTS: 76

Multiple System Atrophy (MSA) malady

Neuronal diseases category

Summaries for Multiple System Atrophy

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Sources:
42NIH Rare Diseases, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Multiple system atrophy (msa) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  msa affects both men and women primarily in their 50s.  the disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. the cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested. there is no cure for this condition, and there is no known way to prevent the disease from getting worse. the goal of treatment is to control symptoms.  last updated: 10/7/2010

MalaCards: Multiple System Atrophy, also known as shy-drager syndrome, is related to parkinson's disease and progressive supranuclear palsy. An important gene associated with Multiple System Atrophy is COQ2 (coenzyme Q2 4-hydroxybenzoate polyprenyltransferase), and among its related pathways are Neuroscience and Alpha-synuclein signaling. The compounds dopamine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are nervous system and behavior/neurological.

NINDS:43 Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects both men and women primarily in their 50s.

Genetics Home Reference:21 Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.

Wikipedia:63 Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the... more...

Description from OMIM:46 146500

Aliases & Classifications for Multiple System Atrophy

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
multiple system atrophy:
Inheritance: Autosomal recessive,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

multiple system atrophy 8 42 21 43 46 10 44 48 30 60
shy-drager syndrome 8 21 43 60
msa 42 21 48
striatonigral degeneration 21 60
multisystem atrophy 48
opca 21


External Ids:

Disease Ontology8 DOID:4752
MeSH34 D012791
OMIM46 146500
NCIt39 C85066
SNOMED-CT56 16576004, 230297002
MESH via Orphanet35 D019578
ICD10 via Orphanet26 G90.3
SNOMED-CT via Orphanet57 230297002
UMLS via Orphanet61 C0393571

Related Diseases for Multiple System Atrophy

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Multiple System Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.5RPS27A, DRD2, SNCB, SNCG, SNCA, MAOB
2progressive supranuclear palsy31.2MAPT, SLC6A3
3dementia30.9LRRK2, SLC6A3, SERPINA3, TSPO, MAPT, MAOB
4olivopontocerebellar atrophy30.8SNCA, TSPO
5lewy body dementia30.8SNCA, SNCB
6striatonigral degeneration30.8RPS27A, DRD2, SNCA, SLC6A3
7brain disease30.7SNCA, CHAT, MAPT, SERPINA3, TSPO
8spinocerebellar ataxia30.6RPS27A, FMR1, SNCA, MAPT
9alzheimer's disease30.5RPS27A, TSPO, SERPINA3, PVALB, DRD2, SQSTM1
10amyotrophic lateral sclerosis30.2RPS27A, PVALB, SQSTM1, CRYAB, SNCA, CHAT
11huntington's disease30.2DRD2, CHAT
12essential tremor30.2FMR1, SNCA, LRRK2, SLC6A3
13rem sleep behavior disorder30.2SNCA, SLC6A3
14multiple sclerosis30.2DRD2, CRYAB, TSPO
15lateral sclerosis30.2SNCA, MAPT
16movement disease30.2SNCA, LRRK2
17motor neuron disease30.2RPS27A, PVALB, SQSTM1, SNCA, MAPT, GDNF
18pick's disease29.9RPS27A, SQSTM1, CRYAB, SNCA, CHAT, MAPT
19cadasil29.9PVALB, CHAT, MAOB, MAPT, GDNF, SERPINA3
20myositis29.9RPS27A, SNCA, MAPT, SERPINA3
21bipolar disorder29.9PVALB, DRD2, MAOB, DBH, GDNF, SLC6A3
22tauopathy29.9RPS27A, SNCA, MAPT, LRRK2
23dysautonomia29.9SNCA, DBH
24myotonic dystrophy29.9MAPT, CRYAB, FMR1
25pure autonomic failure29.9SNCA, DBH
26breast cancer29.9MAPT, SNCA, SNCG, CRYAB, SQSTM1, DRD2
27neuronitis10.7
28striatonigral degeneration infantile10.6
29cerebritis10.5
30sleep disorder10.5
31cerebellar ataxia10.4
32multiple system atrophy with orthostatic hypotension10.4
33sporadic infantile bilateral striatal necrosis10.4
34skin atrophy10.3
35bullous pemphigoid10.3
36neuroleptic malignant syndrome10.3
37machado-joseph disease10.2
38apraxia10.2
39cerebellar disease10.2
40eye disease10.2
41respiratory failure10.2
42muscular atrophy10.1
43spinal muscular atrophy10.1
44spinocerebellar ataxia type 710.1
45blepharospasm10.1
46fragile x syndrome10.1
47basal ganglia disease10.1
48cervicitis10.1
49glucose metabolism disease10.1
50laryngitis10.1

Graphical network of the top 20 diseases related to Multiple System Atrophy:



Diseases related to multiple system atrophy

Clinical Features for Multiple System Atrophy

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

146500

Clinical synopsis from OMIM:

146500

Drugs & Therapeutics for Multiple System Atrophy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Multiple System Atrophy

Drug clinical trials:

Search ClinicalTrials for Multiple System Atrophy

Search NIH Clinical Center for Multiple System Atrophy

Search CenterWatch for Multiple System Atrophy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Multiple System Atrophy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Multiple System Atrophy:
Mesenchymal stem cells for multiple system atrophy
Embryonic/Adult Cultured Cells Related to Multiple System Atrophy:
Bone marrow-derived mesenchymal stem cells, PMID: 19513327

Genetic Tests for Multiple System Atrophy

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Anatomical Context for Multiple System Atrophy

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Multiple System Atrophy:

32
Brain, Testes, Bone, Eye, Skin, Bone marrow, Cortex, Heart, Colon, Temporal lobe, Subthalamic nucleus, Olfactory bulb, Skeletal muscle, Cerebellum, Whole blood, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Multiple System Atrophy:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Multiple System Atrophy or affiliated genes

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36MGI
See all sources

MGI Mouse Phenotypes related to Multiple System Atrophy:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.8SLC6A3, PVALB, FMR1, DRD2, SQSTM1, CRYAB
2MP:000538610.8SNCG, CRYAB, SQSTM1, DRD2, FMR1, PVALB
3MP:000537810.8CRYAB, SQSTM1, DRD2, FMR1, SNCB, SNCA
4MP:000538410.8PVALB, FMR1, DRD2, SQSTM1, SNCG, SNCA
5MP:001077110.7FMR1, DRD2, SQSTM1, SNCA, MAPT, DBH
6MP:000539410.7SNCA, SLC6A3
7MP:000536910.6PVALB, DRD2, CRYAB, CHAT, MAPT, GDNF
8MP:001076810.6DRD2, SQSTM1, CRYAB, SNCB, SNCA, CHAT
9MP:000537610.5SNCG, SNCB, SQSTM1, DRD2, SNCA, CHAT
10MP:000301210.5LRRK2, MAPT, SNCA, SNCB, DRD2, PVALB
11MP:000537910.4FMR1, DRD2, SNCA, DBH, GDNF, LRRK2
12MP:000536710.2DRD2, SNCA, MAOB, MAPT, GDNF, LRRK2

Publications for Multiple System Atrophy

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50PubMed
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Articles related to Multiple System Atrophy:

(show top 50)    (show all 679)
idTitleAuthorsYear
1
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. (24243499)
2013
2
Models of Multiple System Atrophy. (24338664)
2013
3
Genetic association study of glucocerebrosidase gene L444P mutation in essential tremor and multiple system atrophy in mainland China. (23151436)
2013
4
The value of putaminal diffusion imaging versus 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy. (24243813)
2013
5
Longitudinal quantitative MRI in multiple system atrophy and progressive supranuclear palsy. (24239142)
2013
6
Neuromelanin magnetic resonance imaging in Parkinson's disease and multiple system atrophy. (23796701)
2013
7
Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients. (23652420)
2013
8
"Hot cross bun" sign resembling multiple system atrophy in a patient with Machado-Joseph disease. (24212526)
2013
9
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease. (22994884)
2013
10
Iron deficiency in parkinsonism: region-specific iron dysregulation in Parkinson's disease and multiple system atrophy. (24113558)
2013
11
Skin temperature of the hand in multiple system atrophy and Parkinson's disease. (23453042)
2013
12
The neuropathology, pathophysiology and genetics of multiple system atrophy. (22074330)
2012
13
Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy. (21983018)
2012
14
I+-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy. (23098910)
2012
15
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model. (22161470)
2012
16
Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study). (21320989)
2011
17
Pregnancy in multiple system atrophy: a case report. (22208291)
2011
18
The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom. (21931694)
2011
19
Role of dysautonomic symptoms in distinguishing Parkinson's disease (PD) from multiple system atrophy (MSA-P) within a year of developing motor symptoms. (21751644)
2011
20
Involvement of pontine transverse and longitudinal fibers in multiple system atrophy: a tractography-based study. (21310434)
2011
21
Multiple system atrophy: a clinical and neuropathological perspective. (21962754)
2011
22
Conjugal parkinsonism: multiple system atrophy and Parkinson's disease. (20061176)
2010
23
Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone. (20701753)
2010
24
Apraxia contributes to the motor deficit in Parkinson's Disease and multiple system atrophy. (20050895)
2010
25
Dyspnea as first sign of autonomic failure in postmortem confirmed multiple system atrophy. (20669251)
2010
26
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy. (19514077)
2009
27
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. (19405128)
2009
28
Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy. (21686637)
2009
29
Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy? (19460374)
2009
30
Risk factors of multiple system atrophy: a case-control study in French patients. (18307243)
2008
31
Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations. (18463858)
2008
32
Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy. (18185098)
2008
33
Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study. (17334661)
2007
34
More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains. (17476513)
2007
35
Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy. (17853477)
2007
36
Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson's disease. (17510732)
2007
37
Hyperintensity of the middle cerebellar peduncles on fluid-attenuated inversion recovery imaging: variation with age and implications for the diagnosis of multiple system atrophy. (17110685)
2006
38
Neuropsychological functions in progressive supranuclear palsy, multiple system atrophy and Parkinson's disease. (16936386)
2006
39
Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy. (15607204)
2005
40
Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy. (15654557)
2005
41
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. (14991385)
2004
42
Blepharospasm associated with multiple system atrophy: a case report and review of the literature. (15036172)
2004
43
Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease. (15133823)
2004
44
Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy. (14639688)
2003
45
Serum prolactin levels in Parkinson's disease and multiple system atrophy. (12420085)
2002
46
The nature of the autonomic dysfunction in multiple system atrophy. (12127669)
2002
47
Erythropoietin deficiency and anaemia in multiple system atrophy. (11295775)
2001
48
Evolution of sporadic olivopontocerebellar atrophy into multiple system atrophy. (10953186)
2000
49
Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. (10537069)
1999
50
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease. (9452329)
1998

Genetic Variations for Multiple System Atrophy

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Multiple System Atrophy:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1COQ2p.Phe29LeuVAR_070239
2COQ2p.Pro49HisVAR_070240
3COQ2p.Ser57ThrVAR_070241
4COQ2p.Met78ValVAR_070243
5COQ2p.Ile97ThrVAR_070244
6COQ2p.Pro107SerVAR_070245
7COQ2p.Ser113PheVAR_070246
8COQ2p.Thr267AlaVAR_070247
9COQ2p.Ser297CysVAR_070248
10COQ2p.Arg337GlnVAR_070250
11COQ2p.Val343AlaVAR_070251

Expression for genes affiliated with Multiple System Atrophy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Multiple System Atrophy

Search GEO for disease gene expression data for Multiple System Atrophy.

Pathways for genes affiliated with Multiple System Atrophy

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Sources:
4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Multiple System Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5LRRK2, DBH, MAPT, SNCA, SNCB, FMR1
210.5SNCA, MAOB, SLC6A3
3
Hide members
10.5SLC6A3, MAOB, DRD2
410.5SLC6A3, LRRK2, SNCA

Compounds for genes affiliated with Multiple System Atrophy

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.0RPS27A, PVALB, DRD2, MAOB, MAPT, DBH
2glutamate4411.0DBH, GDNF, SLC6A3, TSPO, CHAT, MAPT
3levodopa44 1112.0TSPO, SLC6A3, RPS27A, DRD2, SNCA, MAOB
4acetylcholine44 49 28 11 2415.0TSPO, SERPINA3, RPS27A, SLC6A3, GDNF, DBH
5mptp4411.0RPS27A, DRD2, SNCA, TSPO, SLC6A3, GDNF
66-hydroxydopamine4411.0RPS27A, DRD2, SNCA, MAOB, DBH, GDNF
7gaba4411.0GDNF, DBH, SLC6A3, MAOB, CHAT, DRD2
8cocaine44 1112.0DBH, MAOB, SLC6A3, TSPO, CHAT, GDNF
9methamphetamine44 49 1113.0MAOB, RPS27A, PVALB, DRD2, SNCA, CHAT
10h2o24411.0SLC6A3, DBH, MAPT, MAOB, SNCB, CRYAB
11norepinephrine44 11 2413.0TSPO, SLC6A3, GDNF, DBH, MAOB, CHAT
12choline44 11 2412.9PVALB, SNCA, CHAT, MAOB, MAPT, SLC6A3
13apomorphine44 28 1112.9DRD2, SNCA, GDNF, MAOB, SLC6A3, CHAT
14nmda44 2811.9RPS27A, PVALB, CHAT, MAPT, MAOB, TSPO
15silver4410.9FMR1, RPS27A, PVALB, SERPINA3, MAPT, CHAT
16nicotine44 49 28 1113.9DRD2, CHAT, MAOB, MAPT, DBH, TSPO
17haloperidol44 28 2 49 1114.9DRD2, TSPO, CHAT, MAOB, SLC6A3, PVALB
18d amphetamine4410.9MAOB, TSPO, SLC6A3, DRD2
19spec-t4410.9MAPT, DRD2, MAOB, SLC6A3, TSPO
20rotenone4410.9SLC6A3, MAOB, SNCA, TSPO, RPS27A
21amphetamine44 1111.9MAOB, SNCA, DRD2, GDNF, SLC6A3
225-hydroxytryptamine4410.9MAOB, TSPO, CHAT, DRD2, DBH, SLC6A3
23creatinine4410.9FMR1, SLC6A3, TSPO, RPS27A, SERPINA3, MAOB
24maoa4410.9SLC6A3, DRD2, MAOB, DBH
25valine4410.9TSPO, SERPINA3, SLC6A3, MAPT, SNCA, RPS27A
261 methyl 4 phenylpyridinium4410.9SLC6A3, GDNF, MAOB, SNCA
27paraffin4410.9CRYAB, SNCA, CHAT, RPS27A, MAPT, PVALB
28selegiline44 1111.9MAOB, GDNF, SLC6A3, SNCA
29alpha-methyl-p-tyrosine4410.8DBH, SLC6A3, DRD2
30estrogen4410.8PVALB, SNCG, CHAT, MAOB
31thioflavine s4410.8MAPT, SNCA, RPS27A
32l-amino acid4410.8MAOB, GDNF, CHAT, DBH
33iron44 2411.8PVALB, SERPINA3, GDNF, DBH, SNCA, SNCG
34catecholamine4410.8GDNF, SNCA, DBH, MAOB, CHAT
35kainate44 2811.8GDNF, MAPT, CHAT, PVALB, TSPO
36aspartate4410.8SLC6A3, GDNF, MAPT, CHAT, CRYAB, RPS27A
37serine4410.8MAOB, DBH, MAPT, SNCA, SQSTM1, PVALB
38alanine4410.8SERPINA3, SNCA, RPS27A, CHAT, DBH, GDNF
39formaldehyde44 2411.7PVALB, CHAT, RPS27A, DBH, MAPT
40carbidopa44 2811.7SLC6A3, DBH, MAOB
41imipramine44 49 28 11 2414.7SLC6A3, CHAT, MAOB, DBH
42cysteine4410.7SERPINA3, SLC6A3, GDNF, DBH, MAPT, MAOB
43dopac4410.7MAOB, GDNF, DBH
44guanidine hydrochloride4410.6SERPINA3, SNCA, MAOB, RPS27A
45opiate4410.6DRD2, DBH, SLC6A3, TSPO
46mhpg4410.6MAOB, DBH, SERPINA3
47superoxide44 2411.5CRYAB, SNCB, MAOB, GDNF, SERPINA3, DBH
48nadph44 2411.5DBH, PVALB, SERPINA3, SQSTM1, CHAT, MAPT
49methylphenidate44 49 1112.4DRD2, SLC6A3, MAOB
50reserpine44 28 1112.2MAOB, SLC6A3, DRD2

GO Terms for genes affiliated with Multiple System Atrophy

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Sources:
16Gene Ontology
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Cellular components related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:03042610.5MAPT, SNCA, SNCB
2axonGO:03042410.4SLC6A3, MAPT, CHAT, SNCA, DRD2, PVALB
3neuronal cell bodyGO:04302510.2SNCB, SNCG, CHAT, LRRK2, SLC6A3

Biological processes related to Multiple System Atrophy according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249310.9TSPO, SLC6A3, MAOB, SNCA, SNCG, DRD2
2agingGO:00756810.9TSPO, SLC6A3, SNCA, CRYAB
3regulation of dopamine secretionGO:01405910.9DRD2, SNCG, SNCA
4response to cocaineGO:04222010.8SLC6A3, SNCG, DRD2
5synapse organizationGO:05080810.8SNCB, SNCG, SNCA
6adult walking behaviorGO:00762810.8MAPT, CHAT, DRD2
7adult locomotory behaviorGO:00834410.8SNCG, SNCA, GDNF
8regulation of dopamine uptake involved in synaptic transmissionGO:05158410.8DRD2, GDNF
9dopamine catabolic processGO:04242010.8DBH, SLC6A3
10synaptic transmissionGO:00726810.8SNCB, SNCG, CHAT, DBH, SLC6A3
11negative regulation of intracellular transportGO:03238710.8CRYAB, MAPT
12regulation of locomotionGO:04001210.8LRRK2, SNCA
13adenohypophysis developmentGO:02198410.8SLC6A3, DRD2
14behavioral response to ethanolGO:04814910.7DRD2, DBH
15negative regulation of apoptotic processGO:04306610.7GDNF, SNCA, CRYAB, SQSTM1, RPS27A
16peristalsisGO:03043210.7DRD2, GDNF
17locomotory behaviorGO:00762610.7DRD2, DBH, SLC6A3
18dopamine biosynthetic processGO:04241610.6SLC6A3, SNCA
19dopamine metabolic processGO:04241710.6SNCB, DRD2
20behavioral response to cocaineGO:04814810.6DRD2, SNCA
21response to iron ionGO:01003910.5DRD2, SLC6A3
22neurotransmitter biosynthetic processGO:04213610.5SLC6A3, CHAT
23prepulse inhibitionGO:06013410.4SLC6A3, DRD2
24negative regulation of neuron apoptotic processGO:04352410.2GDNF, SNCA, SNCB

Molecular functions related to Multiple System Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alpha-tubulin bindingGO:04301410.6SNCA, SNCG, SNCB
2protein homodimerization activityGO:04280310.5LRRK2, GDNF, MAOB, CRYAB, SQSTM1
3beta-tubulin bindingGO:04848710.5SNCA, SNCG, SNCB
4identical protein bindingGO:04280210.4DRD2, SQSTM1, CRYAB, SNCA, LRRK2
5dopamine bindingGO:03524010.2SLC6A3, DRD2

Products for genes affiliated with Multiple System Atrophy

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  • Antibodies
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Sources for Multiple System Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet