Multiple System Atrophy malady

NIH Rare Diseases: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination.  MSA affects both men and women primarily in their 50s.  The disease tends to advance rapidly over the course of 9 to 10 years, with progressive loss of motor skills, eventual confinement to bed, and death. The cause of multiple system atrophy is unknown, although environmental toxins, trauma, and genetic factors have been suggested. There is no cure for this condition, and there is no known way to prevent the disease from getting worse. The goal of treatment is to control symptoms. ³⁰

MalaCards: Multiple System Atrophy, also known as shy-drager syndrome, is related to parkinson's disease and progressive supranuclear palsy. An important gene associated with Multiple System Atrophy is NUB1 (negative regulator of ubiquitin-like proteins 1), and among its related pathways are Tyrosine metabolism p.1 (dopamine) and Tyrosine metabolism p.1 (dopamine). The compounds nicotine and glucose have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

NINDS: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure such as fainting spells and bladder control problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects both men and women primarily in their 50s. ³¹

Genetics Home Reference: Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure.¹⁷

Wikipedia: Multiple-system atrophy (MSA) is a degenerativeneurological disorder. MSA is associated with the...⁴⁴ more...

Aliases & Descriptions:

multiple system atrophy 6 30 17 31 8 32 43 shy-drager syndrome 6 17 31 43 striatonigral degeneration 17 43

msa 30 17 multiple system atrophy (disorder) 6 opca 17

Diseases related to multiple system atrophy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 731)

id	Related Disease	Score	Top Affiliating Genes
1	parkinson's disease	36.9	PARK7, UCHL1, MAPT, TBP, SNCA, GBA
2	progressive supranuclear palsy	33.9	PARK7, PARK2, CHAT, CDK5, APOE, MAPT
3	supranuclear palsy	33.2	PARK7, PARK2, CHAT, MTAP, CDK5, APOE
4	striatonigral degeneration	32.7	MAP2, DRD2, SNCA, RPS27A, STRN, SLC6A3
5	pure autonomic failure	32.0	SNCA, TH, DBH
6	olivopontocerebellar atrophy	31.7	ATXN3, ATXN1, ATN1, HTT, CACNA1A, PVALB
7	spinocerebellar ataxia type 7	31.6	ATXN3, ATXN2, ATXN1, ATN1, ATXN7, HSPA4
8	pick's disease	31.0	PARK7, BDNF, CHAT, UCHL1, APOE, MBP
9	tauopathy	30.6	PARK7, PARK2, CDK5, MAPT, HTT, SNCA
10	corticobasal degeneration	30.5	MAPT, SNCA, RPS27A, HCRT
11	tremor	30.3	PARK7, PARK2, UCHL1, ATXN2, ATP13A2, FRAXA
12	spinocerebellar degeneration	30.3	ATXN3, ATXN2, ATXN1, CACNA1A, GLUD1, RPS27A
13	orthostatic hypotension	30.2	CALCA, SST, DBH, NPPA, EPO
14	riley-day syndrome	30.2	BDNF, IKBKAP, DBH
15	dysautonomia	29.5	PARK2, BDNF, FMR1, IKBKAP, SNCAIP, SNCA
16	alcoholism	29.4	MAPT, MAOB, GLUD1, TPH1, DRD2, SNCA
17	amyotrophic lateral sclerosis (als)	29.3	RAB5A, CDK5, TNF, DRD2, GFAP, PVALB
18	postural hypotension	29.2	SST, DBH, NPPA, EPO
19	autonomic dysfunction	28.6	BDNF, UCHL1, ATXN3, ATXN2, IL6, MAPT
20	huntington's disease	28.4	SERPINA3, BDNF, CHAT, UCHL1, ATXN3, ATXN1
21	bullous pemphigoid	27.7	IL10, IL1A, IL1B, IL6, IL8, ICAM1
22	ataxia	26.6	RABEP1, PARK7, ATXN3, ATXN2, ATXN8OS, ATXN1
23	lateral sclerosis	25.7	RAB5A, PARK7, PARK2, BDNF, CHAT, MT3
24	amyotrophic lateral sclerosis	25.7	RAB5A, PARK7, PARK2, BDNF, CHAT, MT3
25	respiratory failure	25.5	CHAT, IL10, IL1B, IL6, IL8, MAPT
26	breast cancer	24.9	IL10, IL1B, IL6, IL8, TNF, CYP2D6
27	dementia	22.7	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
28	twinning	22.5	BDNF, CFH, ATXN3, ATXN1, ATN1, FMR1
29	neurodegeneration	21.8	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
30	myopathy	21.4	PARK2, BDNF, CHAT, CFH, ATN1, IL1A
31	neuronitis	21.2	SERPINA3, BSN, RAB3A, RAB5A, RABEP1, PARK7
32	alzheimer's disease	21.0	SERPINA3, RAB3A, RAB5A, RABEP1, PARK7, PARK2
33	blindness	20.9	CFH, ATXN7, IL10, IL1A, IL1B, IL6
34	anemia	20.7	PARK2, UBB, CFH, IL10, IL1A, IL1B
35	cholesterol	19.7	SERPINA3, RAB3A, RAB5A, BDNF, CHAT, MT3
36	cerebritis	18.9	SERPINA3, PARK7, PARK2, BDNF, CHAT, MT3
37	prostatitis	17.2	SERPINA3, RAB5A, PARK7, PARK2, BDNF, UCHL1
38	alexander disease	14.0	CRYAB, RPS27A, GFAP
39	rem sleep behavior disorder	14.0	SNCA, RPS27A, SLC6A3
40	wernicke encephalopathy	14.0	MAPT, GFAP, TSPO, PRNP
41	parkinsonian disorders	14.0	MAPT, SLC6A3, NEFL
42	parkinson disease 10	14.0	PARK7, PARK2, SNCA, LRRK2
43	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	14.0	APTX, HTT, SLC6A3
44	central neurocytoma	14.0	MAP2, SNCA, GFAP
45	movement disease	14.0	PARK7, PARK2, FMR1, MAPT, HTT, DRD2
46	neurilemmoma	14.0	MBP, SNCG, SNCA, CRYAB, ACTC1, GFAP
47	primary progressive aphasia	13.9	MAPT, LRRK2, PRNP
48	hallervorden-spatz syndrome	13.9	SNCG, SNCB, SNCA
49	fibrillary astrocytoma	13.9	SNCG, SNCB, SNCA
50	parkinson disease type 3	13.9	PARK7, PARK2, MAPT, SNCAIP, SNCA, LRRK2

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to multiple system atrophy:

²²

MGI Mouse Phenotypes related to multiple system atrophy:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	10.2	ADH7, SLC6A3, SNCA, DRD2, HTT, MAPT
2	endocrine/exocrine gland phenotype	MP:0005379	9.8	GLUD1, ETV6, LRRK2, DBH, HTT, MCPH1
3	renal/urinary system phenotype	MP:0005367	9.7	NPPA, SNCA, DRD2, MAOB, MAPT, APOE
4	respiratory system phenotype	MP:0005388	9.4	TPH1, DRD2, NDUFS4, LRRK2, HCRT, TH
5	skeleton phenotype	MP:0005390	9.3	CRYAB, NDUFS4, TACR1, SQSTM1, RGS14, C3
6	no phenotypic analysis	MP:0003012	9.3	TBP, SST, SNCB, SNCA, LRRK2, PRNP
7	hematopoietic system phenotype	MP:0005397	9.2	GDNF, EPO, RGS14, SQSTM1, LRRK2, ETV6
8	digestive/alimentary phenotype	MP:0005381	8.6	CRYAB, NOS2, GFAP, TGFB1, NPY, C3
9	integument phenotype	MP:0010771	8.5	GBA, IKBKAP, MAP1B, MAPT, FMR1, CDK5
10	liver/biliary system phenotype	MP:0005370	8.2	GBA, EPO, C3, SQSTM1, TH, DRD2
11	immune system phenotype	MP:0005387	7.9	CRYAB, NDUFS4, LRRK2, GFAP, PRNP, SQSTM1
12	normal phenotype	MP:0002873	7.7	PVALB, TH, GFAP, ACTC1, NDUFS4, PRNP
13	adipose tissue phenotype	MP:0005375	7.4	NOS2, EIF4EBP1, TGFB1, SQSTM1, NPY, C3
14	nervous system phenotype	MP:0003631	7.4	GDNF, GBA, ADH7, C3, RGS14, SIRT2
15	vision/eye phenotype	MP:0005391	7.0	CRYAB, NOS2, NDUFS4, GFAP, TH, TGFB1
16	reproductive system phenotype	MP:0005389	6.7	TNF, DRD2, SNCA, NOS2, TGFB1, PRNP
17	muscle phenotype	MP:0005369	6.4	GFAP, HCRT, ACTC1, NDUFS4, NOS2, CRYAB
18	behavior/neurological phenotype	MP:0005386	6.3	RGS14, SIRT2, SLC6A4, SLC6A3, NPY, SQSTM1
19	growth/size phenotype	MP:0005378	6.0	PARK2, PARK7, RAB3A, BDNF, GDNF, GBA
20	mortality/aging	MP:0010768	5.9	SNCB, PPP1R14C, SUMO1, TBP, DRD2, ETV6
21	cellular phenotype	MP:0005384	5.2	EIF4EBP1, LRRK2, NDUFS4, NOS2, CRAT, SNCA
22	homeostasis/metabolism phenotype	MP:0005376	4.7	CALCA, BDNF, PARK2, PARK7, RAB3A, CHAT
23	cardiovascular system phenotype	MP:0005385	4.5	TH, GFAP, HCRT, ACTC1, LRRK2, NDUFS4

Articles related to multiple system atrophy:

(show top 50)    (show all 147)

id	Title	Authors	Year	Affiliating Genes
1	Complement 3 and factor h in human cerebrospinal flui d in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy. (21435440)	Wang Y.... Zhang J.	2011	CFH, C3
2	The comparison of clonidine, arginine and both combin ed: a growth hormone stimulation test to differentiate multiple system atrophy from idiopathic Parkinson's disease. (20405138)	Zhang K.... Wan Q.	2010	GH1
3	A negative electroretinogram (ERG) in a case of probable multiple system atrophy (MSA). (19023607)	Barnes C.S.... Wilmot G.R.	2009	ATXN1
4	The G2019S LRRK2 Mutation is Rare in Korean Patients with Parkinson's Disease and Multiple System Atrophy. (19513331)	Cho J.W.... Jeon B.S.	2009	LRRK2
5	Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy. (19332698)	Segarane B.... Houlden H.	2009	GBA
6	Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes. (18442140)	Soma H.... Sasaki H.	2008	CARS, SQSTM1, EIF4EBP1
7	Analyses of copy number and mRNA expression level of the alpha-synuclein gene in multiple system atrophy. (19845160)	Jin H.... Mizusawa H.	2008	SNCA
8	Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan. (18450497)	Lu C.S.... Wu-Chou Y.H.	2008	LRRK2
9	Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy? (18553090)	Fujishiro H.... Dickson D.W.	2008	SNCA
10	Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. (18808062)	Honjo Y.... Akiguchi I.	2008	PPP1R1B
11	CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease. (16678934)	Abdo W.F.... Verbeek M.M.	2007	MAPT, NEFL
12	Involvement of hypocretin neurons in multiple system atrophy. (17089135)	Benarroch E.E.... Parisi J.E.	2007	HCRTR1
13	p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. (17823288)	Song Y.J.... Jensen P.H.	2007	SNCA, MBP, TPPP
14	Medullary microvessel degeneration in multiple system atrophy. (17466525)	Miller V.M.... Kenny R.A.	2007	ACTC1
15	Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy. (17659646)	Martinez-Rodriguez J.E.... Poewe W.	2007	HCRT
16	The alpha-synuclein gene in multiple system atrophy. (16543523)	Ozawa T.... Wood N.W.	2006	SNCA
17	Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy. (15607204)	Infante J.... Combarros O.	2005	ICAM1, IL8
18	FMR1 premutations associated with fragile X-associated tremor/ataxia syndrome in multiple system atrophy. (15956167)	Biancalana V.... Durr A.	2005	FMR1
19	Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. (15838855)	Nishimura M.... Kawakami H.	2005	BDNF
20	Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia. (16284907)	Miller D.W.... Young A.B.	2005	SNCA
21	Brain SPECT imaging in multiple system atrophy. (16284908)	Cilia R.... Antonini A.	2005	DRD2
22	False-positive SCA8 gene test in a patient with pathologically proven multiple system atrophy. (15732096)	Factor S.A.... Payami H.	2005	ATXN8OS
23	The fragile X tremor ataxia syndrome in the differential diagnosis of multiple system atrophy: data from the EMSA Study Group. (15947063)	Kamm C.... Gasser T.	2005	FMR1
24	Annular alpha-synuclein species from purified multiple system atrophy inclusions. (15228606)	Pountney D.L.... Gai W.P.	2004	SNCA
25	Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy. (14743371)	Armstrong R.A.... Cairns N.J.	2004	SNCA
26	Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease. (15133823)	Abdo W.F.... Verbeek M.M.	2004	TPPP3
27	Imaging of dopamine transporters and D2 receptors in patients with Parkinson's disease and multiple system atrophy. (15583914)	Knudsen G.M.... Werdelin L.	2004	SLC6A3
28	Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy. (14698448)	Lin W.L.... Dickson D.W.	2004	SNCA
29	Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. (14991385)	Neumann M.... Kahle P.J.	2004	SNCA, PARK7
30	123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. (12601452)	Berding G.... Knapp W.H.	2003	SLC6A3, SLC6A4
31	Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy. (12833405)	Cho S.... Kim K.S.	2003	DBH
32	Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. (12811584)	Giasson B.I.... Trojanowski J.Q.	2003	MAPT
33	Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy. (12669242)	Komori T.... Oda M.	2003	YWHAB
34	Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. (12875980)	Hishikawa N.... Sobue G.	2003	PARK2, RNF19A
35	Observations on haematological and cardiovascular effects of erythropoietin treatment in multiple system atrophy with sympathetic failure. (12269555)	Winkler A.S.... Chaudhuri K.R.	2002	EPO
36	Pathology of the inferior olivary nucleus in patients with multiple system atrophy. (12012086)	Sakurai A.... Gonatas N.K.	2002	SNCA, RPS27A
37	The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease. (11145981)	Campbell B.C.... Li Q.X.	2001	SNCA
38	Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. (11307630)	Piao Y.S.... Takahashi H.	2001	MAPT, SNCA
39	Erythropoietin deficiency and anaemia in multiple system atrophy. (11295775)	Winkler A.S.... Chaudhuri K.R.	2001	EPO
40	Altered expression of calcium- and apoptosis-regulating proteins in multiple system atrophy Purkinje cells. (10752575)	WA1llner U.... Klockgether T.	2000	PVALB
41	The alpha-synucleinopathies: Parkinson's disease, dem entia with Lewy bodies, and multiple system atrophy. (11193145)	Spillantini M.G.... Goedert M.	2000	SNCA
42	Accumulation of NACP/alpha-synuclein in lewy body disease and multiple system atrophy. (10766891)	Shoji M.... Hirai S.	2000	SNCA
43	Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are alpha-synucleinopathies. (18591134)	Spillantini M.G.	1999	SNCA
44	Multiple-system atrophy: a new alpha-synuclein disease? (9716068)	Gai W.P.... Blessing W.W.	1998	SNCA
45	Cyclin-dependent kinase 5 and mitogen-activated protein kinase in glial cytoplasmic inclusions in multiple system atrophy. (9690673)	Nakamura S.... Kimura J.	1998	CDK5
46	NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. (9829806)	Arima K.... Kawai M.	1998	SNCA
47	Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. (9726379)	Spillantini M.G.... Goedert M.	1998	SNCA
48	Iodine-123-epidepride-SPECT: studies in Parkinson's disease, multiple system atrophy and Huntington's disease. (9374338)	Pirker W.... BrA1cke T.	1997	DRD2
49	Benzodiazepine receptor binding in the cerebellum in multiple system atrophy and olivopontocerebellar atrophy studied with positron emission tomography. (8615166)	Gilman S.... St Laurent R.T.	1996	TSPO
50	Octreotide effects on orthostatic hypotension in pati ents with multiple system atrophy: a controlled study of acute administration. (8665540)	Bordet R.... Libersa C.	1995	SST

Genes related to multiple system atrophy according to GeneCards:

(show top 50)    (show all 108)

id	Symbol	Description	Score	GeneCards Section Context
1	NUB1	negative regulator of ubiquitin-like proteins 1	11.0	Summaries
2	SNCB	synuclein, beta	11.0	Publications
3	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
4	SNCG	synuclein, gamma (breast cancer-specific protein 1)	11.0	Publications
5	SQSTM1	sequestosome 1	11.0	Publications
6	FMR1	fragile X mental retardation 1	11.0	Publications
7	PVALB	parvalbumin	11.0	Publications
8	CHAT	choline O-acetyltransferase	11.0	Publications
9	CRYAB	crystallin, alpha B	11.0	Publications
10	CDK5	cyclin-dependent kinase 5	11.0	Publications
11	DRD2	dopamine receptor D2	11.0	Publications
12	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
13	MAPT	microtubule-associated protein tau	11.0	Publications
14	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
15	GDNF	glial cell derived neurotrophic factor	11.0	Publications
16	GFAP	glial fibrillary acidic protein	11.0	Publications
17	MAOB	monoamine oxidase B	11.0	Publications
18	LRRK2	leucine-rich repeat kinase 2	11.0	Publications
19	TSPO	translocator protein (18kDa)	11.0	Publications
20	RPS27A	ribosomal protein S27a	11.0	Publications
21	GLUD1	glutamate dehydrogenase 1	11.0
22	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
23	MAP2	microtubule-associated protein 2	11.0	Publications
24	MBP	myelin basic protein	11.0	Publications
25	PRNP	prion protein	11.0	Publications
26	HTT	huntingtin	11.0
27	TACR1	tachykinin receptor 1	11.0	Publications
28	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0
29	ATXN1	ataxin 1	11.0	Publications
30	TH	tyrosine hydroxylase	11.0	Publications
31	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
32	FRAXA	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	11.0	Publications
33	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
34	ATXN8OS	ATXN8 opposite strand (non-protein coding)	11.0	Publications
35	NEFL	neurofilament, light polypeptide	11.0	Publications
36	MT3	metallothionein 3	11.0	Publications
37	NDUFA5	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa	11.0	Publications
38	RNF19A	ring finger protein 19A, E3 ubiquitin protein ligase	11.0	Publications
39	RAB3A	RAB3A, member RAS oncogene family	11.0	Publications
40	SEPT8	septin 8	11.0	Disorders
41	PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	11.0	Publications
42	TPPP	tubulin polymerization promoting protein	11.0	Publications
43	MSX1	msh homeobox 1	11.0	Publications
44	ATP13A2	ATPase type 13A2	11.0
45	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	11.0	Publications
46	ATN1	atrophin 1	11.0	Publications
47	APTX	aprataxin	11.0	Publications
48	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
49	SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	11.0	Publications
50	SHC2	SHC (Src homology 2 domain containing) transforming protein 2	11.0	Publications

Pathways related to multiple system atrophy according to GeneDecks:

(show all 47)

id	Pathway	Score	Top Affiliating Genes
1	Tyrosine metabolism p.1 (dopamine)41	10.7	ADH7, DBH, TH, MAOB
2	Tyrosine metabolism p.1 (dopamine)10	10.7	ADH7, DBH, TH, MAOB
3	RAR-Gamma-RXR-Alpha Degradation36	10.7	TBP, UBB
4	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.5	NPY, DBH, TH, CACNA1A, CHAT
5	Parkinsons disease20	10.5	SLC6A3, TH, LRRK2, NDUFS4, NDUFA5, SNCA
6	Neuroscience3	10.4	BSN, PPP1R1B, SNCB, SNCA, LRRK2, GFAP
7	Parkinsons Disease Pathway36	10.2	SLC6A3, SNCA, SNCAIP, HSPA4, UBB, UCHL1
8	Transcription NF-kB signaling pathway10	10.1	SUMO1, IKBKAP, IL1A, UBB
9	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	10.1	RNF19A, SNCA, SNCAIP, HSPA8, HSPA4, PARK2
10	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	10.1	RNF19A, SNCA, SNCAIP, HSPA8, HSPA4, PARK2
11	CDK5 Pathway36	10.1	PPP1R1B, PPP2R2B, DRD2, CACNA1A, MAPT, CDK5
12	Proteolysis Putative ubiquitin pathway10	10.1	SNCAIP, HSPA8, HSPA4, ATXN3, UBB, PARK2
13	Proteolysis_Putative ubiquitin pathway41	10.1	SNCAIP, HSPA8, HSPA4, ATXN3, UBB, PARK2
14	IL-6 Pathway36	9.9	PPP1R1B, PPP2R2B, IL8, IL10
15	NFAT Signaling and Lymphocyte Interactions36	9.9	CACNA1A, IL1A
16	Alzheimers disease20	9.4	NDUFS4, NDUFA5, SNCA, TNF, MAPT, APOE
17	Selected targets of GCR-alpha10	9.3	MAP2, IL8, IL6, IL1B, CHAT
18	Transcription_NF-kB signaling pathway41	9.2	SUMO1, TNF, IKBKAP, IL1A, UBB
19	Akt Signaling36	9.0	EIF4EBP1, TNF, IL6, IL10
20	Leishmaniasis20	8.8	C3, TGFB1, NOS2, TNF, IL1B, IL1A
21	14-3-3 Induced Intracellular Signaling36	8.7	BDNF, YWHAB, MAPT, GH1, TNF, SNCA
22	IL-10 Pathway36	8.7	TNF, IL6, IL1B, IL1A, IL10
23	Immune response_MIF-mediated glucocorticoid regulation41	8.6	NOS2, TNF, ICAM1, IL8, IL6
24	Immune response MIF-mediated glucocorticoid regulation10	8.6	NOS2, TNF, ICAM1, IL8, IL6
25	Immune response_MIF in innate immunity response41	8.6	NOS2, TNF, IL8, IL6, IL1B
26	ERK Signaling36	8.6	TGFB1, PPP1R1B, PPP2R2B, CACNA1A, IL6, IL1B
27	Immune response MIF in innate immunity response10	8.6	NOS2, TNF, IL8, IL6, IL1B
28	African trypanosomiasis20	8.6	IL10, IL1B, IL6, ICAM1, TNF
29	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.5	TNF, CALCA, CALB1, APOE, IL6, IL1B
30	Cytokine Network36	8.5	TNF, IL8, IL6, IL1B, IL1A, IL10
31	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.5	TNF, CALCA, CALB1, APOE, IL6, IL1B
32	Immune response IL-1 signaling pathway10	8.4	NOS2, TNF, IL8, IL6, IL1B, IL1A
33	Immune response_IL-1 signaling pathway41	8.4	NOS2, TNF, IL8, IL6, IL1B, IL1A
34	PEDF Induced Signaling36	8.3	GDNF, TNF, IL8, IL6, IL1B, IL1A
35	Rheumatoid arthritis20	8.2	TGFB1, TNF, ICAM1, IL8, IL6, IL1B
36	Amoebiasis20	8.2	TGFB1, NOS2, TNF, IL8, IL6, IL1B
37	Malaria20	8.1	TGFB1, TNF, ICAM1, IL8, IL6, IL1B
38	Pertussis20	8.1	C3, NOS2, TNF, IL8, IL6, IL1B
39	Tuberculosis20	8.1	C3, TGFB1, NOS2, TNF, IL6, IL1B
40	all-trans-Retinoic Acid Signaling in Brain36	8.1	TNF, CACNA1A, IL8, IL6, IL1B, IL1A
41	TGF-Beta Pathway36	8.0	TGFB1, PPP2R2B, GH1, IL8, IL6, IL1B
42	NF-KappaB (p50-p65) Pathway36	7.9	TGFB1, TNF, GH1, IL6, IL1B, IL1A
43	Chagas disease (American trypanosomiasis)20	7.8	C3, TGFB1, NOS2, PPP2R2B, TNF, IL8
44	JAK-STAT Pathway36	7.8	EPO, TGFB1, GH1, IL8, IL6, IL1B
45	Influenza A20	7.7	TNF, HSPA8, ICAM1, IL8, IL6, IL1B
46	PAK Pathway36	7.2	TGFB1, TNF, GH1, IL8, IL6, IL1B
47	Cytokine-cytokine receptor interaction20	7.2	EPO, TGFB1, TNF, GH1, IL8, IL6

Compounds related to multiple system atrophy according to GeneDecks:

(show top 50)    (show all 320)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.7	CYP2D6, PPP1R1B
2	glucose32	10.6	PARK2, CDK5, CALB1, GLUD1, CRYAB, ACTC1
3	n acetylcysteine32	10.1	BDNF, CDK5, APOE, MBP, MAPT, SNCA
4	1 methyl 4 phenylpyridinium32	9.9	PARK2, BDNF, MAOB, CYP2D6, SNCA, NDUFS4
5	choline32 9 18 9	12.9	CHAT, MAPT, MAP2, MAOB, CALB1, GLUD1
6	levodopa32 9 9	11.9	PARK7, BDNF, CDK5, MAOB, GH1, TPH1
7	silver32	9.8	SERPINA3, BDNF, CHAT, FMR1, MBP, MAPT
8	amphetamine32 9 9	11.8	MAOB, TPH1, DRD2, CYP2D6, SST, SNCA
9	haloperidol32 34 9 9	12.8	BDNF, CHAT, MAOB, HCRT, TH, PVALB
10	methamphetamine32 9 9	11.8	BDNF, CHAT, MAP2, MAOB, CALB1, TPH1
11	rotenone32	9.8	PARK7, PARK2, IL1A, MAOB, HSPA4, HSPA8
12	6-hydroxydopamine32	9.7	PARK7, PARK2, BDNF, CHAT, CDK5, MAOB
13	formaldehyde32 18	10.7	CHAT, IL1A, MBP, MAPT, CALB1, TBP
14	mptp32	9.6	PARK2, BDNF, MAOB, CALB1, DRD2, SST
15	cysteine32	9.5	SERPINA3, RAB5A, PARK7, UCHL1, MT3, CFH
16	spec-t32	9.4	APOE, MAPT, MAOB, CALCA, DRD2, SST
17	cocaine32 9 9	11.3	BDNF, CHAT, CDK5, IL1A, MBP, MAP2
18	5-hydroxytryptamine32	9.3	CHAT, IL1A, MAOB, CALB1, CALCA, TPH1
19	gaba32 42	10.2	BDNF, CHAT, FMR1, MBP, MAP2, MAP1B
20	polyacrylamide32	9.2	SERPINA3, MT3, ATXN3, ATXN2, ATXN7, MAP1B
21	alanine32	9.2	PARK2, CHAT, CFH, IL6, MBP, HTT
22	epinephrine32 9 18 9	12.2	BDNF, IL1A, MBP, MAOB, DRD2, CRAT
23	kainate32	9.2	BDNF, CHAT, APOE, MBP, MAPT, MAP2
24	aspartate32	9.2	BDNF, CHAT, APOE, MBP, GLUD1, GH1
25	histamine32 18	10.2	BDNF, MAOB, ICAM1, CALCA, SST, HCRT
26	glutamate32	9.1	CHAT, MT3, CDK5, FMR1, MBP, MAPT
27	iron32 18	10.1	SERPINA3, PARK2, BDNF, HTT, HSPA4, HSPA8
28	oxygen32 18	10.1	SERPINA3, PARK7, PARK2, BDNF, MT3, CDK5
29	corticosterone32 18	10.0	BDNF, IL1A, IL1B, MBP, MAP2, HSPA8
30	h2o232	8.8	PARK7, PARK2, BDNF, CDK5, APOE, MBP
31	paraffin32	8.7	SERPINA3, CHAT, IL10, APOE, MBP, MAPT
32	nmda32 42	9.5	PARK2, BDNF, CHAT, CDK5, IL1A, APOE
33	mg 13232 42	9.3	PARK2, IL1A, IL1B, IL8, MAPT, ICAM1
34	dopamine32 9 18 9	11.2	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
35	creatinine32	8.2	SERPINA3, BDNF, MT3, FMR1, IL1A, MBP
36	superoxide32 18	9.2	SERPINA3, PARK7, PARK2, UCHL1, MT3, CDK5
37	nitric oxide32 9 18 9	11.1	PARK2, CHAT, IL10, IL1A, IL1B, IL6
38	adenylate32	8.0	BDNF, MTAP, MBP, MAP2, HSPA4, HSPA8
39	glutamine32	7.9	PARK2, ATXN3, ATXN2, ATXN1, ATN1, ATXN7
40	estrogen32	7.9	SERPINA3, PARK2, BDNF, CHAT, MT3, APOE
41	testosterone32 9 18 9	10.8	PARK7, PARK2, BDNF, CHAT, ATXN3, ATXN1
42	acetylcholine32 9 18 9	10.7	SERPINA3, BDNF, CHAT, IL1A, APOE, MBP
43	norepinephrine32 9 18 9	10.5	RAB3A, BDNF, CHAT, IL1A, IL6, MBP
44	tyrosine32	6.8	RAB5A, PARK7, PARK2, BDNF, CHAT, UCHL1
45	retinoic acid32 42 18	8.2	BDNF, CHAT, CFH, MSX1, CDK5, IL1A
46	actinomycin d32	6.0	BDNF, IL1A, IL1B, IL6, IL8, APOE
47	serine32	6.0	SERPINA3, PARK2, BDNF, YWHAB, UCHL1, CFH
48	lactate32	5.9	BDNF, CHAT, IL6, IL8, MBP, MAPT
49	dexamethasone32 42 34 9 9	9.5	SERPINA3, CHAT, MT3, CFH, IL10, IL1A
50	vegf32	4.3	PARK2, BDNF, IL10, IL1A, IL1B, IL6

Cellular components related to multiple system atrophy according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	inclusion body	GO:016234	10.4	MT3, HTT, SNCA
2	perikaryon	GO:043204	10.2	TH, DRD2, CACNA1A, MAP1B, CDK5
3	axon	GO:030424	10.1	DRD2, SNCA, TGFB1, PVALB, SLC6A3, NEFL
4	dendrite	GO:030425	9.9	SUMO1, TACR1, DBH, RGS14, DRD2, CACNA1A
5	synaptic vesicle	GO:008021	9.8	HCRT, LRRK2, HSPA8, MT3, RAB3A
6	perinuclear region of cytoplasm	GO:048471	9.6	NPPA, HCRT, NOS2, SNCA, SNCG, TPPP
7	neuronal cell body	GO:043025	9.3	CHAT, SLC6A3, DBH, STRN, TGFB1, LRRK2
8	cytosol	GO:005829	7.8	RPS27A, NOS2, CRYAB, SNCA, PPP1R1B, TPH1
9	cytoplasm	GO:005737	6.7	ACTC1, LRRK2, NOS2, CRYAB, SNCA, SNCAIP
10	extracellular region	GO:005576	6.3	HCRT, TGFB1, DBH, NPPA, NPY, C3
11	extracellular space	GO:005615	5.7	GH1, TNF, SST, TGFB1, NPY, C3

Biological processes related to multiple system atrophy according to GeneDecks:

(show all 45)

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine biosynthetic process	GO:042416	10.8	SLC6A3, TH, SNCA
2	visual learning	GO:008542	10.8	RGS14, DBH, PPP1R1B, DRD2, HTT, CDK5
3	negative regulation of intracellular transport	GO:032387	10.8	MAPT, MAP1B, CRYAB
4	regulation of dopamine secretion	GO:014059	10.7	DRD2, SNCG, SNCA
5	adult walking behavior	GO:007628	10.7	DRD2, CACNA1A, MAPT, UCHL1, CHAT
6	microtubule bundle formation	GO:001578	10.7	MAP2, MAP1B, TPPP, TPPP3
7	locomotory behavior	GO:007626	10.6	SLC6A3, DBH, STRN, TH, DRD2, CALB1
8	regulation of synaptic plasticity	GO:048167	10.5	CALB1, HTT, CDK5, BDNF
9	negative regulation of neuron apoptotic process	GO:043524	10.5	GDNF, SNCA, SNCB, CACNA1A, HTT, MT3
10	response to ozone	GO:010193	10.4	DBH, TACR1, IL1B, IL1A
11	dopamine metabolic process	GO:042417	10.4	SNCAIP, SNCB, DRD2
12	response to amphetamine	GO:001975	10.4	DBH, PPP1R1B, DRD2, ICAM1
13	negative regulation of neuroblast proliferation	GO:007406	10.4	TGFB1, LRRK2, BDNF
14	response to ethanol	GO:045471	10.4	ADH7, SLC6A3, TACR1, TH, ACTC1, ICAM1
15	dendrite development	GO:016358	10.4	BDNF, CHAT, MAP1B, STRN
16	response to copper ion	GO:046688	10.3	PRNP, DBH, ICAM1, IL1A
17	feeding behavior	GO:007631	10.3	NPY, HCRTR1, DRD2, CALCA, BDNF
18	behavioral response to pain	GO:048266	10.2	TACR1, TSPO, CACNA1A
19	negative regulation of MAP kinase activity	GO:043407	10.2	GBA, RGS14, APOE, IL1B, UCHL1
20	memory	GO:007613	10.2	SLC6A4, DBH, TH, IL1B, CHAT
21	positive regulation vascular endothelial growth factor production	GO:010575	10.0	C3, TGFB1, IL1B, IL1A
22	positive regulation of necrotic cell death	GO:010940	10.0	MT3, TNF, TSPO
23	neuron projection development	GO:031175	10.0	GDNF, NPY, MAP2, IL6, CDK5
24	synaptic transmission	GO:007268	9.8	SNCB, HCRT, HCRTR1, DBH, NPY, SLC6A3
25	aging	GO:007568	9.8	EPO, SLC6A3, TGFB1, TSPO, CRYAB, CALCA
26	social behavior	GO:035176	9.8	IL1B, HTT, DBH, SLC6A4
27	cellular response to hypoxia	GO:071456	9.8	EPO, RPS27A, ICAM1, MT3, UBB
28	cellular response to lipopolysaccharide	GO:071222	9.7	IL10, IL8, ICAM1, NOS2, TSPO
29	response to heat	GO:009408	9.7	TACR1, SST, CALCA, HSPA4, IL1B
30	positive regulation of protein complex assembly	GO:031334	9.7	TGFB1, SUMO1, TNF, TPPP
31	cell death	GO:008219	9.5	PARK7, GBA, SLC6A3, TGFB1, C10orf2, SNCAIP
32	response to estradiol stimulus	GO:032355	9.4	SLC6A4, DBH, TGFB1, CRYAB, GH1, MAP1B
33	protein kinase B signaling cascade	GO:043491	9.4	MT3, IL1B, TNF, TGFB1
34	positive regulation of protein phosphorylation	GO:001934	9.4	C3, TGFB1, LRRK2, TNF, IL1B, MT3
35	MAPK cascade	GO:000165	9.3	TGFB1, LRRK2, TNF, IL1B, YWHAB
36	regulation of I-kappaB kinase/NF-kappaB cascade	GO:043122	9.1	SQSTM1, TNF, IL1B
37	negative regulation of transcription, DNA-dependent	GO:045892	8.9	SIRT2, TGFB1, SUMO1, TNF, CALCA, HSPA8
38	response to hypoxia	GO:001666	8.8	SLC6A4, TGFB1, TH, NOS2, CRYAB, DRD2
39	positive regulation of interleukin-6 production	GO:032755	8.7	IL1A, IL1B, IL6, TNF
40	anti-apoptosis	GO:006916	8.6	CRYAB, RPS27A, PRNP, SQSTM1, EPO, GDNF
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	TGFB1, RPS27A, TNF, ICAM1, IL6, IL1B
42	apoptotic process	GO:006915	8.4	RPS27A, ACTC1, TSPO, SQSTM1, EPO, PPP2R2B
43	response to drug	GO:042493	8.3	SST, SNCA, ACTC1, TSPO, TGFB1, SLC6A3
44	negative regulation of cell proliferation	GO:008285	8.1	STRN, TGFB1, SST, DRD2, TNF, IL8
45	inflammatory response	GO:006954	7.8	CALCA, TNF, TGFB1, TACR1, C3, IL8

Molecular functions related to multiple system atrophy according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	tubulin binding	GO:015631	10.4	PRNP, LRRK2, TPPP3, TPPP, MAP2
2	copper ion binding	GO:005507	10.3	MT3, IL1A, SNCA, DBH, PRNP
3	microtubule binding	GO:008017	10.2	RGS14, PRNP, CRYAB, TPPP, MAP1B, MAPT
4	receptor binding	GO:005102	9.2	GDNF, GBA, C3, SLC6A3, NPY, NPPA
5	protein homodimerization activity	GO:042803	8.9	GDNF, ADH7, SLC6A4, TGFB1, LRRK2, NOS2
6	growth factor activity	GO:008083	8.4	GDNF, TGFB1, GH1, IL6, IL1B, IL10
7	protein binding	GO:005515	3.6	EPO, CRYAB, SNCA, SNCAIP, PPP2R2B, SUMO1