MUMPS
MCID: MMP001
MIFTS: 56

Mumps (MUMPS) malady

Infectious category

Summaries for Mumps

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Mumps is an illness caused by the mumps virus. it starts with fever headache muscle aches tiredness loss of appetite after that, the salivary glands under the ears or jaw become swollen and tender. the swelling can be on one or both sides of the face. symptoms last 7 to 10 days. serious complications are rare. you can catch mumps by being with another person who has it. there is no treatment for mumps, but the measles-mumps-rubella (mmr) vaccine can prevent it. before the routine vaccination program in the united states, mumps was a common illness in infants, children and young adults. now it is a rare disease in the u.s. centers for disease control and prevention

MalaCards: Mumps is related to measles and rubella, and has symptoms including fever, headache and muscle aches. An important gene associated with Mumps is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are IL-22 Pathway and Tuberculosis. The compounds mumps and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include salivary gl, bone marrow and brain, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in salivary gland, has material basis in mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. the infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

CDC:3 Mumps is a contagious disease that is caused by the mumps virus. Mumps typically starts with a few days of fever, headache, muscle aches, tiredness, and loss of appetite, and is followed by swelling of salivary glands. Anyone who is not immune from either previous mumps infection or from vaccination can get mumps. Before the routine vaccination program was introduced in the United States, mumps was a common illness in infants, children and young adults. Because most people have now been vaccinated, mumps has become a rare disease in the United States...more

Wikipedia:64 Mumps (epidemic parotitis) is a viral disease of the human species, caused by the mumps virus. Before... more...

Aliases & Classifications for Mumps

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

mumps 8 43 10 45 34 61


External Ids:

Disease Ontology8 DOID:10264
NCIt40 C29888
ICD9CM27 072
MeSH35 D009107
ICD1025 B26, B26.8, B26.9

Related Diseases for Mumps

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Mumps family:

congenital mumps

Diseases related to Mumps via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1measles31.5IRF1, STAT1, DPT
2rubella31.5DPT
3hepatitis c30.6IFNA2, IRF1, ISG20, STAT1, EIF2AK2
4hepatitis d30.2IFNA2, EIF2AK2
5stomatitis30.0IFNA2
6acute leukemia30.0EIF2AK2, STAT1, IRF1
7asthma30.0NEU1, STAT1, IRF1
8hepatitis b29.7IFNA2, IRF9, IRF1, ISG20, STAT1, DPT
9orchitis10.7
10aseptic meningitis10.6
11parotitis10.6
12meningoencephalitis10.4
13tetanus10.4
14congenital mumps10.4
15endocardial fibroelastosis10.3
16hepatitis a10.3
17diphtheria10.3
18myelitis10.2
19transverse myelitis10.2
20epididymitis10.2
21congenital rubella10.2
22sialadenitis10.2
23chickenpox10.2
24acute pancreatitis10.1
25infertility10.1
26arthritis10.1
27endotheliitis10.1
28acute hemorrhagic leukoencephalitis10.0
29subacute sclerosing panencephalitis10.0
30neuroretinitis10.0
31common wart10.0
32digeorge syndrome10.0
33lymphocytic choriomeningitis10.0
34acute disseminated encephalomyelitis10.0
35viral encephalitis10.0
36autism spectrum disorder10.0
37uveitis10.0
38pityriasis lichenoides10.0
39febrile seizures10.0
40oophoritis10.0
41acute transverse myelitis10.0
42multiple myeloma10.0BST2
43hepatitis10.0IFNA2, IRF1, STAT1
44sarcoma10.0STAT1
45multiple sclerosis10.0EIF2AK2, STAT1, IRF1
46ovarian cancer10.0NEU1, IRF1
47influenza10.0IRF1, ISG20, STAT1, NEU1, EIF2AK2
48myeloid leukemia10.0IRF9, IRF1, STAT2, STAT1, NEU1
49chronic myeloid leukemia10.0EIF2AK2, STAT1, ISG20, IRF2, IFNA2
50myeloma10.0IFNA2, IRF1, STAT1, NEU1

Graphical network of the top 20 diseases related to Mumps:



Diseases related to mumps

Clinical Features for Mumps

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 6)
  • fever
  • headache
  • muscle aches
  • tiredness
  • loss of appetite
  • swollen

Drugs & Therapeutics for Mumps

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Mumps

Drug clinical trials:

Search ClinicalTrials for Mumps

Search NIH Clinical Center for Mumps

Search CenterWatch for Mumps

Genetic Tests for Mumps

Anatomical Context for Mumps

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Mumps:

33
Bone marrow, Brain, Thyroid, Salivary gland, Skin, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal thyroid

FMA organs/tissues related to Mumps:

14
Salivary gl

Animal Models for Mumps or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Mumps:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.9IRF1, IRF2, STAT2, STAT1, NEU1, CHMP4B
2MP:00053979.8MRC1, IRF1, IRF2, BST2, STAT2, STAT1
3MP:00053879.8EIF2AK2, MRC1, IRF9, IRF1, IRF2, BST2
4MP:00053849.6IRF1, IRF2, BST2, STAT2, STAT1, NEU1

Publications for Mumps

Sources:
51PubMed
See all sources

Articles related to Mumps:

(show top 50)    (show all 664)
idTitleAuthorsYear
1
Mumps vaccine effectiveness and risk factors for disease in households during an outbreak in New York City. (24252695)
2014
2
Seroprevalence survey on measles, mumps, rubella and varicella antibodies in healthcare workers in Japan: sex, age, occupational-related differences and vaccine efficacy. (23574767)
2014
3
Circulation of two mumps virus genotypes in an unimmunized population in India. (23657908)
2013
4
Serological survey of mumps immunity among health care workers in the Catalonia region of Spain. (23040604)
2013
5
An assessment on the effectiveness mumps vaccine during a large outbreak among kindergarten children. (24147289)
2013
6
Epidemiologic and genetic characteristics of mumps viruses isolated in China from 1995 to 2010. (24355245)
2013
7
Nonfebrile seizures after mumps, measles, rubella, and varicella-zoster virus combination vaccination with detection of measles virus RNA in serum, throat, and urine. (23637042)
2013
8
New preventive strategy to eliminate measles, mumps and rubella from Europe based on the serological assessment of herd immunity levels in the population. (23417624)
2013
9
Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant. (24426272)
2013
10
Antibodies against mumps virus component proteins. (22215227)
2012
11
When, and how, should we introduce a combination measles-mumps-rubella (MMR) vaccine into the national childhood expanded immunization programme in South Africa? (22939023)
2012
12
No evidence of mumps transmission during air travel, United States, November 1, 2006-October 31, 2010. (22818340)
2012
13
Gene-specific contributions to mumps virus neurovirulence and neuroattenuation. (21543475)
2011
14
Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006. (21470456)
2011
15
Lower long-term immunogenicity of mumps component after MMR vaccine. (20975455)
2010
16
Assessment of humoral and cell-mediated immune response to measles-mumps-rubella vaccine viruses among patients with asthma. (21708062)
2010
17
Effects of mumps outbreak in hospital, Chicago, Illinois, USA, 2006. (20202417)
2010
18
Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial. (19366435)
2009
19
Measles, mumps, rubella, and varicella immunization status of first responders--a policy proposal. (19492756)
2009
20
Characterization of large mumps outbreak among vaccinated Palestinian refugees. (19144793)
2009
21
Investigation of a mumps outbreak among university students with two measles-mumps-rubella (MMR) vaccinations, Virginia, September-December 2006. (19697404)
2009
22
Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. (18440578)
2008
23
The epidemiology of mumps in Italy. (18439732)
2008
24
Mumps. (18342688)
2008
25
Media coverage of the measles-mumps-rubella vaccine and autism controversy and its relationship to MMR immunization rates in the United States. (18381512)
2008
26
A case of fulminant type 1 diabetes associated with significant elevation of mumps titers. (18520103)
2008
27
Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain. (18440271)
2008
28
Enrichment of cerebrospinal fluid samples on cell culture for enhancement of sensitivity of mumps and enterovirus detection by multiplex RT-PCR. (18083320)
2008
29
Increased mumps incidence in the Netherlands: review on the possible role of vaccine strain and genotype. (18761918)
2008
30
Real-time PCR and its application to mumps rapid diagnosis. (17854025)
2007
31
Aseptic meningitis after vaccination with L-Zagreb mumps strain-virologically confirmed cases. Faulty calculation of rates. (17092613)
2007
32
Risks of convulsion and aseptic meningitis following measles-mumps-rubella vaccination in the United Kingdom. (17204517)
2007
33
A case of mumps epididymitis. (16503474)
2006
34
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717299)
2005
35
Safety and immunogenicity of measles-mumps-rubella vaccine in children with congenital immunodeficiency (DiGeorge syndrome). (15705470)
2005
36
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. (12743296)
2003
37
Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1. (12917439)
2003
38
Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps rubella vaccine in the United States. (12456938)
2002
39
Acute transverse myelitis and Guillain-BarrAc overlap syndrome with serological evidence for mumps viraemia. (11589654)
2001
40
Mumps infection complicated by transient hyperinsulinemic hypoglycemia. (9109149)
1997
41
Index of suspicion. Case 3. Mumps parotitis. (7567712)
1995
42
Transverse myelitis unlikely to be due to measles, mumps, and rubella vaccine. (8555831)
1995
43
Systemic treatment with interferon-alpha 2B: an effective method to prevent sterility after bilateral mumps orchitis. (2056606)
1991
44
Isolation of mumps virus from vaginal secretions in association with oophoritis. (3216135)
1988
45
Diagnostic criteria for sudden deafness, mumps deafness and perilymphatic fistula. (3227833)
1988
46
Effects of influenza, mumps, and western equine encephalitis viruses on fetal rhesus monkeys (Macaca mulatta). (117564)
1979
47
Patho-anatomical findings in a case of mumps with pancreatitis, myocarditis, orchitis, epididymitis and seminal vesiculitis. (4971788)
1968
48
MUMPS EPIDIDYMITIS WITHOUT ORCHITIS. (14261468)
1965
49
LEUKEMOID REACTION TO MUMPS VIRUS. (14160741)
1964
50
A case of mumps labyrinthitis. (13491930)
1957

Genetic Variations for Mumps

Expression for genes affiliated with Mumps

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mumps

Search GEO for disease gene expression data for Mumps.

Pathways for genes affiliated with Mumps

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome
See all sources

Compounds for genes affiliated with Mumps

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Mumps according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1mumps4510.6STAT2, STAT1
2cycloheximide4510.6STAT1, IRF1
3inosine monophosphate4510.5EIF2AK2, STAT1, IRF1
4polyinosinic-polycytidylic acid4510.5IRF1, STAT1, EIF2AK2
5ribavirin45 50 1112.4IFNA2, ISG20, STAT1, NEU1, EIF2AK2
6ifn-alpha4510.4IFNA2, IRF9, IRF1, STAT2, STAT1, EIF2AK2
7adenine45 11 2412.4IRF9, IRF1, ISG20, EIF2AK2
8poly(i-c)4510.4IRF1, STAT1, EIF2AK2
9galactose4510.4NEU1, MRC1, IFNA2
10levamisole45 1111.4NEU1, IFNA2
112,5-oligoadenylate4510.3EIF2AK2, IFNA2, IRF9, IRF1, IRF2, ISG20
12retinoic acid45 2411.3IFNA2, IRF9, IRF1, IRF2, STAT2, STAT1
13amantadine45 1111.3NEU1, IFNA2
14oligonucleotide4510.2EIF2AK2, STAT1, ISG20, IRF2, IRF1, IRF9
15tyrosine4510.2IFNA2, PDP1, IRF9, IRF1, IRF2, ISG20
16serine4510.1PDP1, IRF1, IRF2, STAT2, STAT1, NEU1
17gliadin4510.1STAT1, IRF1

GO Terms for genes affiliated with Mumps

Sources:
16Gene Ontology
See all sources

Cellular components related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.1IRF1, IRF2, ISG20, STAT2, STAT1, IRF9
2cytosolGO:0058299.5EIF2AK2, COPE, UBQLN4, IRF9, IRF1, IRF2

Biological processes related to Mumps according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:06033810.5STAT1, STAT2, IFNA2
2interferon-gamma-mediated signaling pathwayGO:06033310.4IRF9, IRF1, IRF2, STAT1
3response to interferon-alphaGO:03545510.3EIF2AK2, BST2
4negative regulation of viral genome replicationGO:04507110.3ISG20, BST2, EIF2AK2
5response to virusGO:00961510.3ISG20, BST2, DHX58, EIF2AK2
6type I interferon-mediated signaling pathwayGO:06033710.3IFNA2, IRF9, IRF1, IRF2, ISG20, STAT2
7cellular response to interferon-betaGO:03545810.3STAT1, IRF1
8cytokine-mediated signaling pathwayGO:01922110.3IFNA2, IRF9, IRF1, IRF2, ISG20, STAT2
9modulation by virus of host morphology or physiologyGO:01904810.2EIF2AK2, DHX58, STAT1, STAT2
10defense response to virusGO:05160710.1EIF2AK2, IFNA2, IRF9, IRF1, ISG20, BST2
11regulation of innate immune responseGO:04508810.1IRF1, DHX58

Molecular functions related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulatory region DNA bindingGO:00097510.1IRF2, IRF9
2protein bindingGO:0055159.7UBQLN4, IRF9, IRF1, IRF2, BST2, STAT2

Products for genes affiliated with Mumps

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mumps

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet