MUMPS
MCID: MMP001
MIFTS: 59

Mumps (MUMPS) malady

Rare diseases, Infectious diseases, Oral diseases categories
Download this MalaCard

Summaries for Mumps

About this section
Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Mumps is an illness caused by the mumps virus. it starts with fever headache muscle aches tiredness loss of appetite after that, the salivary glands under the ears or jaw become swollen and tender. the swelling can be on one or both sides of the face. symptoms last 7 to 10 days. serious complications are rare. you can catch mumps by being with another person who has it. there is no treatment for mumps, but the measles-mumps-rubella (mmr) vaccine can prevent it. before the routine vaccination program in the united states, mumps was a common illness in infants, children and young adults. now it is a rare disease in the u.s. centers for disease control and prevention

MalaCards: Mumps is related to measles and hepatitis, and has symptoms including swollen, tiredness and muscle aches. An important gene associated with Mumps is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are NF-kappaB Signaling and CXCR4-mediated signaling events. The compounds mumps and gliadin have been mentioned in the context of this disorder. Affiliated tissues include salivary gl, salivary gland and testes, and related mouse phenotypes are integument and skeleton.

Disease Ontology:8 A viral infectious disease that results in inflammation located in salivary gland, has material basis in mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. the infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

CDC:4 Mumps is a contagious disease that is caused by the mumps virus. Mumps typically starts with a few days of fever, headache, muscle aches, tiredness, and loss of appetite, and is followed by swelling of salivary glands. Anyone who is not immune from either previous mumps infection or from vaccination can get mumps. Before the routine vaccination program was introduced in the United States, mumps was a common illness in infants, children and young adults. Because most people have now been vaccinated, mumps has become a rare disease in the United States...more

Wikipedia:65 Mumps (epidemic parotitis) is a viral disease of the human species, caused by the mumps virus. Before... more...

Aliases & Classifications for Mumps

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Oral diseases


Aliases & Descriptions:

mumps 8 43 10 45 34 62


External Ids:

Disease Ontology8 DOID:10264
ICD9CM27 072
MeSH35 D009107
NCIt40 C29888
ICD1025 B26, B26.8, B26.9

Related Diseases for Mumps

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Mumps:



Diseases related to mumps

Symptoms for Mumps

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • swollen
  • tiredness
  • muscle aches
  • loss of appetite
  • headache
  • fever

Drugs & Therapeutics for Mumps

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Mumps

Search NIH Clinical Center for Mumps

Genetic Tests for Mumps

About this section

Anatomical Context for Mumps

About this section
Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Mumps:

33
Salivary gland, Testes, B cells, Endothelial, T cells, Thyroid, Skin, Bone marrow, Bone, Brain

FMA organs/tissues related to Mumps:

14
Salivary gl

Animal Models for Mumps or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Mumps:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5STAT1, IRF2, IRF1, NEU1
2MP:00053907.8CFB, NEU1, IRF1, STAT1
3MP:00053977.7NEU1, IRF1, IRF2, STAT2, STAT1, IFNAR2
4MP:00107687.6NEU1, IRF1, IRF2, STAT2, STAT1, IFNAR2
5MP:00053876.9IFNAR2, CFB, NEU1, IRF1, IRF2, STAT2

Publications for Mumps

About this section
Sources:
52PubMed
See all sources

Articles related to Mumps:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. (24313836)
2014
2
Mumps vaccine effectiveness and risk factors for disease in households during an outbreak in New York City. (24252695)
2014
3
Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles-mumps-rubella. (24412300)
2014
4
Seroprevalence survey on measles, mumps, rubella and varicella antibodies in healthcare workers in Japan: sex, age, occupational-related differences and vaccine efficacy. (23574767)
2014
5
Risk Factors for Transmission of Mumps in a Highly Vaccinated Population in Orange County, NY, 2009-2010. (23995590)
2014
6
Investigation of an outbreak of hypersensitivity-type reactions during the 2004 national measles-mumps-rubella vaccination campaign in Brazil. (23246259)
2013
7
Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan. (24270137)
2013
8
Outbreak-related mumps vaccine effectiveness among a cohort of children and of young adults in Germany 2011. (24091837)
2013
9
Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage. (23661802)
2013
10
Characterisation of mumps virus genotype C among patients with mumps in India. (23883719)
2013
11
Spermiogram part of population with the manifest orchitis during an ongoing epidemic of mumps. (22937687)
2012
12
Establishment of a standard seed lot system of an Iranian Mumps virus strain; RS-12, for mass production of mumps and MMR vaccines. (23115712)
2012
13
Seroepidemiology of mumps in Europe (1996-2008): why do outbreaks occur in highly vaccinated populations? (22687578)
2012
14
Acupuncture for mumps in children. (22972121)
2012
15
Pityriasis lichenoides et varioliformis acuta: a rare association with the measles, mumps and rubella vaccine. (23157791)
2012
16
Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. (23217121)
2012
17
Air-coupled MUMPs capacitive micromachined ultrasonic transducers with resonant cavities. (22099252)
2012
18
Mumps exposure of a health care provider working in a neonatal intensive care unit leads to a hospital-wide effort that prevented an outbreak. (21641085)
2011
19
Mumps virus encephalitis with symmetric claustrum lesions. (21659481)
2011
20
Vaccines for measles, mumps, rubella, varicella, and herpes zoster: immunization guidelines for adults. (22086887)
2011
21
A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein. (20727167)
2010
22
Lower long-term immunogenicity of mumps component after MMR vaccine. (20975455)
2010
23
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
24
Closer look at autism and the measles-mumps-rubella vaccine. (21071320)
2010
25
Mumps vaccine effectiveness in highly immunized populations. (20226249)
2010
26
Role of laboratory in rapid diagnosis of atypical mumps. (20563452)
2010
27
Molecular differences between two Jeryl Lynn mumps virus vaccine component strains, JL5 and JL2. (19656963)
2009
28
An office-based prospective study of deafness in mumps. (19209100)
2009
29
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. (19007835)
2009
30
Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. (19625458)
2009
31
Mumps: not an innocent bystander in solid organ transplantation. (19563333)
2009
32
Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial. (19366435)
2009
33
Mumps outbreak on the island of Anglesey, North Wales, December 2008-January 2009. (19215718)
2009
34
Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. (18440578)
2008
35
Detection of mumps virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform. (18945836)
2008
36
The role of air travel in the spread of mumps. (18831704)
2008
37
Updated recommendations for isolation of persons with mumps. (18846033)
2008
38
Mumps epidemiology and immunity: the anatomy of a modern epidemic. (18820583)
2008
39
Mumps outbreak in a highly vaccinated school population: assessment of secondary vaccine failure using IgG avidity measurements. (17498856)
2007
40
Assessing participation bias in a population-based study of measles-mumps-rubella vaccine immunity in children and adolescents aged 12-18. (17564596)
2007
41
Comparison of the safety and immunogenicity of a refrigerator-stable versus a frozen formulation of ProQuad (measles, mumps, rubella, and varicella virus vaccine live). (17502347)
2007
42
Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)
2005
43
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
44
Mumps epididymo-orchitis with prolonged detection of virus in semen and the development of anti-sperm antibodies. (15042662)
2004
45
The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997. (12435771)
2002
46
Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies. (10390298)
1999
47
Systemic alpha-interferon therapy: a possible method for prevention of testicular atrophy and permanent sterility in patients with bilateral mumps orchitis]. (1926670)
1991
48
Mumps pancreatitis without parotitis. (4692679)
1973
49
LEUKEMOID REACTION TO MUMPS VIRUS. (14160741)
1964
50
Mumps meningoencephalitis with and without parotitis. (18147966)
1949

Variations for Mumps

About this section

Expression for genes affiliated with Mumps

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Mumps

Search GEO for disease gene expression data for Mumps.

Pathways for genes affiliated with Mumps

About this section
Sources:
50PathCards, 5Cell Signaling Technology, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 60Thomson Reuters, 55Reactome, 30KEGG
See all sources

Pathways related to Mumps according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IRF2, IRF1
29.6STAT1, STAT2
3
Show member pathways
IL27-mediated signaling events38
9.6STAT2, STAT1
4
Show member pathways
9.6STAT1, STAT2
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.6STAT2, STAT1
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.6STAT1, IRF1
7
Show member pathways
Immune response MIF in innate immunity response60
9.6STAT1, IRF1
89.6IRF1, STAT1
99.6IRF1, STAT1
109.6IFNAR2, IRF1
11
Show member pathways
9.2IFNA2, IRF1, IRF2
129.2IRF2, IFNA2, IRF1
13
Show member pathways
9.2IRF1, IRF2, IFNA2
14
Show member pathways
IFN-gamma pathway38
9.2STAT1, STAT2, IRF1
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1IFNA2, STAT1, IRF1
169.1STAT1, STAT2, IFNAR2
179.1IFNAR2, STAT1, STAT2
188.6STAT1, IFNA2, STAT2, IFNAR2
19
Show member pathways
Type III interferon signaling38
8.6STAT1, STAT2, IFNAR2, IFNA2
20
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.6IFNA2, STAT1, STAT2, IFNAR2
21
Show member pathways
8.6IFNAR2, STAT2, STAT1, IFNA2
22
Show member pathways
8.6IFNAR2, STAT2, STAT1, IFNA2
238.4IRF1, STAT2, STAT1, IFNA2, IRF2
248.3IFNAR2, IFNA2, STAT1, IRF1, STAT2
25
Show member pathways
7.8IRF1, IFNAR2, STAT2, IRF2, STAT1, IFNA2
26
Show member pathways
7.8IRF1, IFNA2, IFNAR2, STAT2, STAT1, IRF2

Compounds for genes affiliated with Mumps

About this section
Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB
See all sources

Compounds related to Mumps according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1mumps4510.0STAT1, STAT2
2gliadin459.9IRF1, STAT1
3indoleamine459.9STAT1, IRF1
4inosine monophosphate459.8IRF1, STAT1
5deferoxamine45 1110.8STAT1, IRF1
6imiquimod45 61 29 1112.8IFNA2, STAT1
7polyinosinic-polycytidylic acid459.8STAT1, IRF1
8amantadine45 1110.7IFNA2, NEU1
9suberoylanilide hydroxamic acid459.7IRF1, STAT1
10levamisole45 1110.7NEU1, IFNA2
11acyclovir45 1110.7IFNA2, NEU1
12poly(i-c)459.7STAT1, IRF1
13con a459.6IFNA2, NEU1
14vanadate459.6STAT1, STAT2
15retinoid459.4IRF1, STAT1, IFNA2
16etoposide45 51 61 1112.4IRF1, STAT1, IFNA2
17galactose459.4IFNA2, NEU1
18zidovudine45 51 1111.3NEU1, IFNA2
19cellulose acetate459.3NEU1, CFB
20ribavirin45 51 1111.2NEU1, STAT1, IFNA2
21polyethylene glycol459.1IFNA2, NEU1
22agarose458.9CFB, NEU1, IFNA2
23cycloheximide458.9STAT1, IRF2, IRF1, NEU1
24estrogen458.8NEU1, IRF1, STAT1, IFNA2
25lipid458.7IRF1, STAT1, IFNA2, IFNAR2
26ifn-alpha458.6IRF1, STAT2, STAT1, IFNA2, IFNAR2
272,5-oligoadenylate458.2IFNAR2, IFNA2, STAT1, STAT2, IRF2, IRF1
28tyrosine458.2IRF1, IRF2, STAT2, STAT1, IFNA2, IFNAR2
29serine457.8CFB, NEU1, IRF1, IRF2, STAT2, STAT1
30retinoic acid45 248.6NEU1, IRF1, IRF2, STAT2, STAT1, IFNA2

GO Terms for genes affiliated with Mumps

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.6STAT1, IRF1
2nucleoplasmGO:0056548.5STAT1, STAT2, IRF2, IRF1

Biological processes related to Mumps according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-betaGO:0354589.6IRF1, STAT1
2interferon-gamma-mediated signaling pathwayGO:0603339.2STAT1, IRF2, IRF1
3JAK-STAT cascadeGO:0072599.2IFNAR2, STAT1, STAT2
4apoptotic processGO:0069159.1IFNA2, STAT1, IRF1
5regulation of transcription from RNA polymerase II promoterGO:0063579.0IFNAR2, STAT1, STAT2
6blood coagulationGO:0075968.9IRF1, IRF2, IFNA2
7defense response to virusGO:0516078.9IRF1, STAT2, STAT1, IFNA2
8regulation of type I interferon-mediated signaling pathwayGO:0603388.8IFNAR2, IFNA2, STAT1, STAT2
9type I interferon signaling pathwayGO:0603378.1IFNAR2, IFNA2, STAT1, STAT2, IRF2, IRF1
10cytokine-mediated signaling pathwayGO:0192218.0IRF1, IRF2, STAT2, STAT1, IFNA2, IFNAR2

Molecular functions related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.6STAT1, IRF1
2sequence-specific DNA binding transcription factor activityGO:0037008.5STAT1, STAT2, IRF2, IRF1

Products for genes affiliated with Mumps

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Mumps

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet