MUMPS
MCID: MMP001
MIFTS: 59

Mumps (MUMPS) malady

Infectious diseases category

Summaries for Mumps

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Mumps is an illness caused by the mumps virus. it starts with fever headache muscle aches tiredness loss of appetite after that, the salivary glands under the ears or jaw become swollen and tender. the swelling can be on one or both sides of the face. symptoms last 7 to 10 days. serious complications are rare. you can catch mumps by being with another person who has it. there is no treatment for mumps, but the measles-mumps-rubella (mmr) vaccine can prevent it. before the routine vaccination program in the united states, mumps was a common illness in infants, children and young adults. now it is a rare disease in the u.s. centers for disease control and prevention

MalaCards: Mumps is related to measles and rubella, and has symptoms including swollen, loss of appetite and tiredness. An important gene associated with Mumps is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are IL-22 Pathway and Tuberculosis. The compounds mumps and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include salivary gl, salivary gland and testes, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in salivary gland, has material basis in mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. the infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

CDC:3 Mumps is a contagious disease that is caused by the mumps virus. Mumps typically starts with a few days of fever, headache, muscle aches, tiredness, and loss of appetite, and is followed by swelling of salivary glands. Anyone who is not immune from either previous mumps infection or from vaccination can get mumps. Before the routine vaccination program was introduced in the United States, mumps was a common illness in infants, children and young adults. Because most people have now been vaccinated, mumps has become a rare disease in the United States...more

Wikipedia:63 Mumps (epidemic parotitis) is a viral disease of the human species, caused by the mumps virus. Before... more...

Aliases & Classifications for Mumps

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

mumps 8 42 10 44 33 60


External Ids:

Disease Ontology8 DOID:10264
NCIt39 C29888
ICD9CM27 072
MeSH34 D009107
ICD1025 B26, B26.8, B26.9

Related Diseases for Mumps

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Mumps family:

Congenital Mumps

Diseases related to Mumps via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1measles31.5IRF1, STAT1, DPT
2rubella31.5DPT
3hepatitis30.6STAT1, IRF1, IFNA2
4influenza30.6NEU1, IRF1, STAT1, ISG20, EIF2AK2
5hepatitis b30.4EIF2AK2, STAT1, DPT, ISG20, IRF1, IFNA2
6stomatitis29.9IFNA2
7ovarian cancer29.9IRF1, NEU1
8hepatitis c29.9IRF1, ISG20, EIF2AK2, IFNA2, STAT1
9acute leukemia29.9IRF1, STAT1, EIF2AK2
10herpes simplex29.9EIF2AK2, NEU1, IRF1, ISG20, STAT1
11leukemia29.9IRF2, IFNA2, IRF1, ISG20, EIF2AK2, STAT1
12asthma29.9IRF1, STAT1, NEU1
13multiple sclerosis29.7EIF2AK2, IRF1, STAT1
14orchitis10.6
15meningitis10.6
16aseptic meningitis10.6
17parotitis10.5
18meningoencephalitis10.4
19encephalitis10.3
20tetanus10.3
21endocardial fibroelastosis10.3
22epididymo-orchitis10.3
23diphtheria10.2
24hepatitis a10.2
25poliomyelitis10.2
26myelitis10.2
27pancreatitis10.2
28pertussis10.2
29hydrocephalus10.2
30purpura10.2
31sialadenitis10.1
32chickenpox10.1
33labyrinthitis10.1
34acute pancreatitis10.1
35infertility10.1
36arthritis10.1
37myocarditis10.1
38congenital mumps10.1
39multiple myeloma10.0BST2
40sarcoma10.0STAT1
41myeloid leukemia10.0NEU1, STAT2, IRF1, IRF9, STAT1
42chronic myeloid leukemia10.0STAT1, ISG20, IRF2, EIF2AK2, IFNA2
43myeloma10.0IFNA2, IRF1, STAT1, NEU1
44hepatitis d10.0EIF2AK2, IFNA2
45carcinoid syndrome10.0IFNA2, IRF2, IRF1
46hepatocellular carcinoma10.0IFNA2, IRF1, NEU1, EIF2AK2
47colon cancer10.0STAT2, STAT1, NEU1, IRF1
48deficiency anemia10.0IFNA2
49tuberculosis10.0MRC1, PDP1, IRF9, IRF1, STAT2, STAT1
50ipex syndrome10.0ISG20, EIF2AK2, NEU1, IRF1, BST2, STAT1

Graphical network of the top 20 diseases related to Mumps:



Diseases related to mumps

Clinical Features for Mumps

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Sources:
8Disease Ontology
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Symptoms:

8
  • swollen
  • loss of appetite
  • tiredness
  • muscle aches
  • headache
  • fever

Drugs & Therapeutics for Mumps

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Mumps

Drug clinical trials:

Search ClinicalTrials for Mumps

Search NIH Clinical Center for Mumps

Search CenterWatch for Mumps

Genetic Tests for Mumps

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Anatomical Context for Mumps

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Mumps:

32
Salivary gland, Testes, B cells, Endothelial, T cells, Skin, Thyroid, Brain, Bone, Bone marrow

FMA organs/tissues related to Mumps:

14
Salivary gl

Animal Models for Mumps or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Mumps:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.9IL10RB, DHX58, CHMP4B, NEU1, STAT1, STAT2
2MP:00053979.8EIF2AK2, IL10RB, NEU1, STAT1, STAT2, BST2
3MP:00053879.8EIF2AK2, DHX58, NEU1, STAT1, STAT2, BST2
4MP:00053849.6IRF1, EIF2AK2, IL10RB, DHX58, NEU1, STAT1

Publications for Mumps

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Sources:
50PubMed
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Articles related to Mumps:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. (24313836)
2014
2
Mumps among highly vaccinated people: Investigation of an outbreak in a French Military Parachuting Unit, 2013. (24035994)
2014
3
Comparison of automated chemiluminescence immunoassays with capture enzyme immunoassays for the detection of measles and mumps IgM antibodies in serum. (24183918)
2014
4
Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan. (24270137)
2013
5
Outbreak-related mumps vaccine effectiveness among a cohort of children and of young adults in Germany 2011. (24091837)
2013
6
Characterisation of mumps virus genotype C among patients with mumps in India. (23883719)
2013
7
Estimates of mumps seroprevalence may be influenced by antibody specificity and serologic method. (24371258)
2013
8
Measles, mumps, and rubella vaccine: a new option to treat common warts? (23786798)
2013
9
A rare complication of coronary angiography: 'iodide mumps'. (23744842)
2013
10
Hydrocephalus due to aqueductal stenosis in a case of mumps meningoencephalitis: A rare complication. (24082949)
2013
11
Complicated mumps viral infection: an unusual presentation affecting only submandibular gland. (23562490)
2013
12
A new method for the detection of neutralizing antibodies against mumps virus. (23861738)
2013
13
Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. (23217121)
2012
14
Immunogenicity and safety of a two-dose regimen of a combined measles, mumps, rubella and varicella live vaccine (ProQuad(Ar)) in infants from 9 months of age. (22406278)
2012
15
Attitudinal and demographic predictors of measles-mumps-rubella vaccine (MMR) uptake during the UK catch-up campaign 2008-09: cross-sectional survey. (21602931)
2011
16
Immunogenicity and safety of an inactivated hepatitis A vaccine when coadministered with measles-mumps-rubella and varicella vaccines in children less than 2 years of age. (21617573)
2011
17
Effect of weather variability on the incidence of mumps in children: a time-series analysis. (21211102)
2011
18
Safety and immunogenicity of coadministering a combined meningococcal serogroup C and Haemophilus influenzae type b conjugate vaccine with 7-valent pneumococcal conjugate vaccine and measles, mumps, and rubella vaccine at 12 months of age. (21191076)
2011
19
Low measles, mumps and rubella (MMR) vaccine uptake in hospital healthcare worker contacts following suspected mumps infection. (20542592)
2010
20
Molecular epidemiological evaluation of the recent resurgence in mumps virus infections in Ireland. (20660212)
2010
21
Ongoing mumps outbreak in a student population with high vaccination coverage, Netherlands, 2010. (20460086)
2010
22
Mumps outbreak - New York, New Jersey, Quebec, 2009. (19940833)
2009
23
Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence. (19660591)
2009
24
Does vaccination with the varicella vaccine within four weeks after the measles, mumps and rubella vaccine reduce protection? (20885799)
2009
25
Commentary: Is Japan deaf to mumps vaccination? (19209099)
2009
26
Comparative analysis of the complete nucleotide sequences of measles, mumps, and rubella strain genomes contained in Priorix-Tetra and ProQuad live attenuated combined vaccines. (19428841)
2009
27
Laboratory diagnosis of mumps in a partially immunized population: The Nova Scotia experience. (21119794)
2009
28
Mumps: a resurgent disease with protean manifestations. (18928441)
2008
29
An increase in the number of mumps cases in the Czech Republic, 2005-2006. (18768117)
2008
30
Recent resurgence of mumps in the United States. (18403766)
2008
31
Antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralizes a heterologous wild-type mumps virus associated with a large outbreak. (18558869)
2008
32
Transmission of the L-Zagreb mumps vaccine virus, Croatia, 2005-2008. (18768116)
2008
33
Measles, mumps and rubella infections and atopic disorders in MMR-unvaccinated and MMR-vaccinated children. (18266826)
2008
34
A new challenge for Europe: introducing a pediatric quadrivalent vaccine for measles, mumps, rubella, and varicella. (18162247)
2007
35
Mumps and the media: changes in the reporting of mumps in response to newspaper coverage. (17435202)
2007
36
Complementary findings in clinical and epidemiologic features of mumps and mumps meningoencephalitis in children without mumps vaccination. (15660864)
2004
37
Surveillance of measles-mumps-rubella vaccine-associated aseptic meningitis in Germany. (12478324)
2002
38
Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. (12145534)
2002
39
Neuronal apoptosis mediated by IL-1 beta expression in viral encephalitis caused by a neuroadapted strain of the mumps virus (Kilham Strain) in hamsters. (11681839)
2001
40
Mumps interstitial nephritis: a case report. (10603152)
1999
41
Transverse myelitis following mumps in an adult -- a case report with MRI correlation. (9405004)
1997
42
Successful interferon-alpha 2 a therapy for a patient with acute mumps orchitis. (7744163)
1995
43
Experimental mumps labyrinthitis in monkeys (Macaca irus)--immunohistochemical and ultrastructural studies. (3061375)
1988
44
Mumps pancreatitis without parotitis. (4692679)
1973
45
Mumps arthritis without parotitis. (5123807)
1971
46
Mumps epididymo-orchitis and its treatment with cortisone. Report of a controlled trial. (13757310)
1961
47
Congenital defects in infants following mumps during pregnancy; a review of the literature and a report of chorioretinitis due to fetal infection. (13417036)
1957
48
Iritis and glaucoma associated with mumps. (13147625)
1954
49
Acute mesenteric vascular occlusion following mumps. (13096824)
1953
50
Acute myocarditis in mumps (epidemic parotitis). (21011878)
1945

Genetic Variations for Mumps

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Expression for genes affiliated with Mumps

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mumps

Search GEO for disease gene expression data for Mumps.

Pathways for genes affiliated with Mumps

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Mumps

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Mumps according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1mumps4410.6STAT2, STAT1
2cycloheximide4410.6STAT1, IRF1
3inosine monophosphate4410.5EIF2AK2, STAT1, IRF1
4polyinosinic-polycytidylic acid4410.5IRF1, STAT1, EIF2AK2
5ribavirin44 49 1112.4IFNA2, ISG20, STAT1, NEU1, EIF2AK2
6ifn-alpha4410.4IFNA2, IRF9, IRF1, STAT2, STAT1, EIF2AK2
7adenine44 11 2412.4IRF9, IRF1, ISG20, EIF2AK2
8poly(i-c)4410.4IRF1, STAT1, EIF2AK2
9galactose4410.4NEU1, MRC1, IFNA2
10levamisole44 1111.4NEU1, IFNA2
112,5-oligoadenylate4410.3EIF2AK2, IFNA2, IRF9, IRF1, IRF2, ISG20
12retinoic acid44 2411.3IFNA2, IRF9, IRF1, IRF2, STAT2, STAT1
13amantadine44 1111.3NEU1, IFNA2
14oligonucleotide4410.2EIF2AK2, STAT1, ISG20, IRF2, IRF1, IRF9
15tyrosine4410.2IFNA2, PDP1, IRF9, IRF1, IRF2, ISG20
16serine4410.1PDP1, IRF1, IRF2, STAT2, STAT1, NEU1
17gliadin4410.1STAT1, IRF1

GO Terms for genes affiliated with Mumps

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16Gene Ontology
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Cellular components related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.1IRF1, IRF2, ISG20, STAT2, STAT1, IRF9
2cytosolGO:0058299.5EIF2AK2, COPE, UBQLN4, IRF9, IRF1, IRF2

Biological processes related to Mumps according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:06033810.5STAT1, STAT2, IFNA2
2interferon-gamma-mediated signaling pathwayGO:06033310.4IRF1, IRF9, IRF2, STAT1
3cellular response to interferon-betaGO:03545810.4IRF1, STAT1
4negative regulation of viral genome replicationGO:04507110.3ISG20, BST2, EIF2AK2
5response to virusGO:00961510.3DHX58, EIF2AK2, BST2, ISG20
6type I interferon-mediated signaling pathwayGO:06033710.3IRF1, STAT1, STAT2, IFNA2, IRF9, IRF2
7cytokine-mediated signaling pathwayGO:01922110.3IRF1, ISG20, STAT1, IRF9, STAT2, IRF2
8response to interferon-alphaGO:03545510.2EIF2AK2, BST2
9modulation by virus of host morphology or physiologyGO:01904810.2DHX58, STAT2, STAT1, EIF2AK2
10defense response to virusGO:05160710.1ISG20, BST2, IFNA2, IRF9, EIF2AK2, DHX58
11regulation of innate immune responseGO:04508810.1DHX58, IRF1

Molecular functions related to Mumps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulatory region DNA bindingGO:00097510.1IRF2, IRF9
2protein bindingGO:0055159.7UBQLN4, IRF9, IRF1, IRF2, BST2, STAT2

Products for genes affiliated with Mumps

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  • Proteins
  • Lysates
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Sources for Mumps

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet