Mumps malady

MedlinePlus: Mumps is an illness caused by the mumps virus. mumps causes fever headache muscle aches tiredness loss of appetite swelling of the salivary glands follows these symptoms. swelling of the glands near the jaw line below the ears may give you "chipmunk cheeks." serious problems are rare, but can include deafness; swelling of the brain, spinal cord, testicles, breasts or ovaries; and pregnancy loss. you can catch mumps by being with another person who has it. there is no treatment for mumps, but the measles-mumps-rubella (mmr) vaccine can prevent it. mumps used to be a common childhood illness. today it is uncommon, with fewer then 1,000 cases per year on average, because of the vaccine. centers for disease control and prevention²³

MalaCards: Mumps is related to orchitis and acute disseminated encephalomyelitis, and has symptoms including fever, headache and muscle aches. An important gene associated with Mumps is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are Graft-versus-host disease and Jak/Stat Pathway. The compounds polyethylene glycol and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include salivary gl, brain and spinal cord, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Disease Ontology: A viral infectious disease that results in inflammation located in salivary gland, has material basis in mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. the infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.⁶

CDC: Mumps is a contagious disease that is caused by the mumps virus. Mumps typically starts with a few days of fever, headache, muscle aches, tiredness, and loss of appetite, and is followed by swelling of salivary glands. Anyone who is not immune from either previous mumps infection or from vaccination can get mumps. Before the routine vaccination program was introduced in the United States, mumps was a common illness in infants, children and young adults. Because most people have now been vaccinated, mumps has become a rare disease in the United States...more²

Wikipedia: Mumps (epidemic parotitis) is a viral disease of the human species, caused by the mumps virus. Before...⁴⁴ more...

Aliases & Descriptions:

mumps 6 30 8 32 23

Diseases related to mumps by text searches and GeneDecks gene sharing:

(show top 50)    (show all 718)

id	Related Disease	Score	Top Affiliating Genes
1	orchitis	29.5	CD4, IL2RB, IFNA2, IFNG, TNF, CRP
2	acute disseminated encephalomyelitis	27.2	MBP, HLA-DQB1, HLA-DRB1, TNF
3	newcastle disease	27.1	UMOD, IRF1, IL2RB, IFNB1, TNF, CXCL10
4	meningitis	23.0	CFB, CD79A, CD4, CD40LG, CD46, IL1B
5	stomatitis	22.5	CD79A, CD4, CD46, ISG20, IRF9, IL1B
6	rubella	21.7	AURKA, MRC1, CD79A, CD40LG, ISG20, IL10RB
7	measles	19.4	AURKA, MRC1, CD79A, CD4, CD40LG, CD46
8	influenza	18.1	UMOD, CD79A, CD4, CD40LG, CD46, ISG20
9	thyroiditis	16.3	UMOD, CFB, AURKA, CD79A, CD4, CD40LG
10	pancreatitis	15.9	AURKA, CD79A, CD4, CD40LG, IRF2, IL18R1
11	respiratory syncytial virus infectious disease	13.7	IRF1, IFNB1, NEU1
12	fetal parainfluenza virus type 3 syndrome	13.7	IFNB1, STAT2, STAT1, NEU1
13	congenital rubella	13.6	CD40LG, IGHV4-39, TPO
14	monoclonal paraproteinemia	13.5	CD79A, HLA-DPB1
15	atypical hemolytic-uremic syndrome	13.5	CFB, CD46, C3
16	toxocariasis	13.5	CD40LG, IGHV4-39, IGHE
17	membranoproliferative glomerulonephritis type 2	13.5	CD79A, CD46, IFNA2, C3
18	smallpox	13.5	CD4, IRF1, IL18R1, DPT
19	chronic myeloid leukemia	13.5	CD46, ISG20, IRF2, IFNA2, EIF2AK2, STAT1
20	pityriasis rosea	13.5	IFNA2, HLA-DQB1, HLA-DRB1
21	autoimmune disease of central nervous system	13.5	CD79A, CD40LG, C3
22	congenital toxoplasmosis	13.5	CD79A, CD40LG
23	leprosy	13.4	MRC1, HLA-DQB1, HLA-DRB1
24	neisseria meningitidis infection	13.4	CD46, IL1RN, C3
25	severe congenital neutropenia	13.4	IL18R1, IFNA2, HLA-DQB1, HLA-DRB1
26	hand, foot and mouth disease	13.4	CD4, CD46, IFNB1, EIF2AK2, STAT2, STAT1
27	lipoid nephrosis	13.4	CD79A, IL2RB, IL4R
28	allergic contact dermatitis of eyelid	13.4	IL4R, ICAM1, CXCL10
29	parainfluenza virus type 3	13.4	IFIH1, IFNB1, ICAM1, EIF2AK2, STAT1, NEU1
30	chickenpox	13.4	MRC1, CD79A, CD4, IGHV4-39, DPT
31	cryptosporidiosis	13.4	CD4, CD40LG, CXCL10
32	chronic progressive multiple sclerosis	13.4	IL2RB, MBP
33	immunodeficiency with hyper igm	13.4	CD79A, CD40LG, IGHE
34	immunodeficiency with hyper igm type 1	13.3	CD79A, CD40LG, IGHE
35	gamma chain deficiency	13.3	IL18R1, IL2RA, IL2RB, IL4R
36	cd40 ligand deficiency	13.3	CD79A, CD40LG, IGHE
37	autoimmune disease of the nervous system	13.3	CD79A, MBP
38	autoimmune thrombocytopenic purpura	13.3	CD79A, CD40LG, IL2RA, IFNA2
39	21-hydroxylase deficiency	13.3	IL2RA, IL2RB, IFNA2, IFNB1, PDP1
40	venezuelan equine encephalitis	13.2	IFNB1, IFNG, STAT2, STAT1
41	primary immunodeficiency disease	13.2	CD4, CD40LG, IGHV4-39, STAT3
42	beryllium disease, chronic	13.2	IFNG, HLA-DPB1
43	hepatitis d	13.2	CD40LG, IGHV4-39, IFNA2, TNF, EIF2AK2
44	primary systemic mycosis	13.2	CD79A, IGHV4-39, TNF
45	immunoglobulin alpha deficiency	13.2	CD79A, CD40LG, IGHE, HLA-DQB1
46	japanese encephalitis	13.2	CD40LG, FADD, IGHV4-39, IFNAR2, TNFRSF1A, DPT
47	retinal vasculitis	13.2	IFNA2, IFNB1, TNF
48	allergic rhinitis	13.2	IL4R, IGHE, ICAM1
49	acute lymphoblastic leukemia	13.2	UMOD, ISG20, IL18R1, IL4R, FADD, HSPB1
50	total iodide organification defect	13.2	TPO, TG

Symptoms: fever, headache, muscle aches, tiredness, loss of appetite, swollen.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to mumps:

²²

FMA organs/tissues related to mumps:

¹¹

MGI Mouse Phenotypes related to mumps:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.0	C3, OCA2, TNFRSF1B, CFB, UMOD
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	CD40LG, IL2RB, IFNG
3	digestive/alimentary phenotype	MP:0005381	9.5	C3, OCA2, STAT1, HSF1, IFNG, CD4
4	hematopoietic system phenotype	MP:0005397	9.2	OCA2, IRF1, IRF2, IL10RB, IL12RB2, IL4R
5	liver/biliary system phenotype	MP:0005370	8.8	C3, OCA2, IFNG, IL6, IL12RB2, IL10RB
6	integument phenotype	MP:0010771	8.7	TNFRSF1A, TNFRSF1B, DPT, OCA2, NEU1, HSF1
7	skeleton phenotype	MP:0005390	8.6	C3, NEU1, STAT1, STAT3, TNFRSF1B, TNFRSF1A
8	nervous system phenotype	MP:0003631	8.1	TG, STAT3, STAT1, CXCL10, NEU1, C3
9	adipose tissue phenotype	MP:0005375	7.9	C3, OCA2, STAT3, DPT, TNFRSF1B, TNFRSF1A
10	growth/size phenotype	MP:0005378	7.7	TPO, TG, STAT3, STAT1, OCA2, NEU1
11	normal phenotype	MP:0002873	7.3	HSPB1, HLA-DQB1, STAT3, STAT1, OCA2, C3
12	reproductive system phenotype	MP:0005389	7.2	C3, OCA2, STAT3, TNFRSF1A, TNF, IFNG
13	muscle phenotype	MP:0005369	7.1	NEU1, STAT1, STAT3, TNFRSF1B, TNFRSF1A, TNF
14	tumorigenesis	MP:0002006	6.8	TNF, TNFRSF1A, TNFRSF1B, EIF2AK2, STAT3, STAT1
15	vision/eye phenotype	MP:0005391	6.7	DPT, STAT3, STAT1, OCA2, NEU1, C3
16	immune system phenotype	MP:0005387	6.2	STAT1, CXCL10, NEU1, STAT3, EIF2AK2, TNFRSF1A
17	mortality/aging	MP:0010768	6.1	IFNG, HSF1, HLA-DQB1, TPO, TNFRSF1A, EIF2AK2
18	cardiovascular system phenotype	MP:0005385	5.6	TNFRSF1A, TNFRSF1B, CRP, STAT3, STAT1, CXCL10
19	homeostasis/metabolism phenotype	MP:0005376	5.5	ICAM1, HLA-DQB1, TPO, TNFRSF1A, TNFRSF1B, CRP
20	cellular phenotype	MP:0005384	4.3	TNFRSF1A, TNF, HLA-DQB1, HSF1, ICAM1, IFNG

Articles related to mumps:

(show all 31)

id	Title	Authors	Year	Affiliating Genes
1	Interaction of mumps virus V protein variants with ST AT1-STAT2 heterodimer: experimental and theoretical studies. (20937132)	Rosas-Murrieta N.H.... Reyes-Leyva J.	2010	STAT1, STAT2
2	Development and evaluation of a rapid immunochromatog raphic test for mumps-specific IgM in oral fluid specimens and use as a matrix for preserving viral nucleic acid for RT-PCR. (20087926)	Warrener L.... Samuel D.	2010	CD40LG
3	Mumps virus small hydrophobic protein targets ataxin- 1 ubiquitin-like interacting protein (ubiquilin 4). (20702650)	Woznik M.... Finsterbusch T.	2010	UBQLN4
4	The paramyxoviruses simian virus 5 and mumps virus re cruit host cell CD46 to evade complement-mediated neutralization. (19457998)	Johnson J.B.... Parks G.D.	2009	C3, CD46
5	Prime-boost vaccination with recombinant mumps virus and recombinant vesicular stomatitis virus vectors elicits an enhanced human im munodeficiency virus type 1 Gag-specific cellular immune response in rhesus mac aques. (19625392)	Xu R.... Clarke D.K.	2009	IFNG
6	Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation. (18567898)	Le Tortorec A.... Dejucq-Rainsford N.	2008	EIF2AK2
7	Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. (18715339)	Dhiman N.... Poland G.A.	2008	TNF, IL2RA, IL6
8	Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine. (18450852)	Ovsyannikova I.G.... Poland G.A.	2008	HLA-DQB1, HLA-DRB1
9	Differential sensitivity to interferon influences the replication and transcription of Urabe AM9 mumps virus variants in nerve cells. (17533145)	Rosas-Murrieta N.... Reyes-Leyva J.	2007	IRF9
10	Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. (16453260)	Ovsyannikova I.G.... Poland G.A.	2006	HLA-DQB1, HLA-DRB1, HLA-DPB1
11	Increase in adhesion molecules in cerebrospinal fluid of children with mumps and mumps meningitis. (16970684)	Sulik A.... Oldak E.	2006	ICAM1
12	Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)	Ovsyannikova I.G.... Poland G.A.	2005	HLA-DQB1, HLA-DRB1, HLA-DPB1
13	Elevated serum C-reactive protein in mumps orchitis. (15602206)	Niizuma T.... Tanaka K.	2004	CRP
14	STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. (12743296)	Ulane C.M.... Horvath C.M.	2003	STAT3
15	Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1. (12917439)	Yokota S.... Fujii N.	2003	STAT1, HSPB1, HSF1
16	Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells. (12584353)	Le Goffic R.... Samson M.	2003	CXCL10
17	Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps rubella vaccine in the United States. (12456938)	Pool V.... Gargiullo P.M.	2002	IGHE
18	Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. (12145534)	Singh V.K.... Nelson C.	2002	MBP
19	Specific humoral immunity in mumps meningitis in chil dren. (11535945)	Kacprzak-Bergman I.... Jasonek J.	2001	CD40LG
20	Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis. (10840112)	Yeniyol C.O.... Ayder A.R.	2000	IFNA2
21	Mumps virus can suppress the effective augmentation of HPC-induced apoptosis by IFN-gamma through disruption of IFN signaling in U937 cells. (10941939)	Hariya Y.... Fuji N.	2000	IFNG
22	Suppression of interferon response gene expression in cells persistently infected with mumps virus, and restoration from its suppression by treatment with ribavirin. (10581390)	Fujii N.... Shirakawa S.	1999	STAT1, EIF2AK2, ISG20
23	Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies. (10390298)	Lindberg B.... Ivarsson S.A.	1999	TPO, TG
24	Poor induction of interferon-induced 2',5'-oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1 alpha. (9856085)	Yokosawa N.... Fujii N.	1998	EIF2AK2
25	Decline of measles-specific immunoglobulin M antibodies after primary measles, mumps, and rubella vaccination. (9521134)	Helfand R.F.... Bellini W.J.	1998	CD40LG
26	Investigation of IFN type-I receptor and IFN regulatory factor expression relating to induction of 2', 5'-oligoadenylate synthetase in cells persistently infected with the mumps virus. (8981353)	Fujii N.... Yashiki T.	1996	IRF2, IRF1
27	Successful interferon-alpha 2 a therapy for a patient with acute mumps orchitis. (7744163)	RA1ther U.... Jipp P.	1995	IFNA2
28	Phenotype distribution of the third component of complement (C3) and of the properdin B factor (BF) in children with mumps meningitis. (8399122)	Hal/asa J.... Schlesinger D.	1993	CFB
29	Systemic treatment with interferon-alpha 2B: an effec tive method to prevent sterility after bilateral mumps orchitis. (2056606)	Erpenbach K.H.	1991	IFNA2
30	Systemic alpha-interferon therapy: a possible method for prevention of testicular atrophy and permanent sterility in patients with bilateral mumps orchitis (1926670)	Erpenbach K.... Derschum W.	1991	IFNA2
31	A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses. (14907962)	Tamm I.... HORSFALL F.L.	1952	UMOD

Genes related to mumps according to GeneCards:

(show top 50)    (show all 59)

id	Symbol	Description	Score	GeneCards Section Context
1	STAT2	signal transducer and activator of transcription 2, 113kDa	11.0	Drugs & Compounds, Publications
2	IRF2	interferon regulatory factor 2	11.0	Publications
3	IRF1	interferon regulatory factor 1	11.0	Publications
4	EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	11.0	Publications
5	STAT1	signal transducer and activator of transcription 1, 91kDa	11.0	Publications, Drugs & Compounds
6	IFNA2	interferon, alpha 2	11.0	Publications
7	NEU1	sialidase 1 (lysosomal sialidase)	11.0
8	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
9	NDUFB4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	11.0
10	CHMP4A	charged multivesicular body protein 4A	11.0
11	UBQLN4	ubiquilin 4	11.0	Publications
12	IRF9	interferon regulatory factor 9	11.0	Publications
13	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
14	AIDA	axin interactor, dorsalization associated	11.0
15	COPE	coatomer protein complex, subunit epsilon	11.0
16	IL10RB	interleukin 10 receptor, beta	11.0	Publications
17	CFB	complement factor B	11.0	Publications
18	CHMP4B	charged multivesicular body protein 4B	11.0
19	MRC1	mannose receptor, C type 1	11.0
20	DPT	dermatopontin	11.0
21	UMOD	uromodulin	11.0	Publications
22	IFNAR2	interferon (alpha, beta and omega) receptor 2	11.0	Publications
23	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications
24	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	11.0
25	IFIH1	interferon induced with helicase C domain 1	11.0	Proteins
26	HSF1	heat shock transcription factor 1	11.0	Publications
27	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0	Publications
28	FADD	Fas (TNFRSF6)-associated via death domain	11.0
29	IL18R1	interleukin 18 receptor 1	11.0	Publications
30	AMOTL1	angiomotin like 1	11.0
31	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
32	C3	complement component 3	11.0	Publications
33	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
34	IL4R	interleukin 4 receptor	11.0	Publications
35	IL2RB	interleukin 2 receptor, beta	11.0	Publications
36	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
37	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
38	CD40LG	CD40 ligand	11.0	Publications
39	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
40	AURKA	aurora kinase A	11.0
41	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
42	TPO	thyroid peroxidase	11.0	Publications
43	HSPB1	heat shock 27kDa protein 1	11.0	Publications
44	OCA2	oculocutaneous albinism II	11.0
45	TG	thyroglobulin	11.0	Publications
46	CD4	CD4 molecule	11.0
47	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	11.0	Publications
48	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0
49	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
50	IL2RA	interleukin 2 receptor, alpha	11.0	Publications

Pathways related to mumps according to GeneDecks:

(show top 50)    (show all 110)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.7	HLA-DPB1
2	Jak/Stat Pathway3	10.6	IL1RN
3	Bacterial infections in CF airways41	10.5	IRF1
4	Immune response IFN alpha/beta signaling pathway10	10.2	STAT2, STAT1, IFNAR2, IRF9, IRF2, IFNB1
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	IL2RA, IL2RB, TNFRSF1A
6	Immune response_IFN alpha/beta signaling pathway41	10.2	STAT1, IFNB1, IRF1, IRF2, IRF9, IFNAR2
7	Immune response IFN gamma signaling pathway10	10.1	STAT1, IFNG, EIF2AK2
8	Immune response_IFN gamma signaling pathway41	9.6	IFNG, IRF1, STAT1, IRF9, EIF2AK2, STAT2
9	Immune response IL-12 signaling pathway10	9.5	IL2RA, IFNG, IRF1, IL12RB2, IL18R1, STAT3
10	Autoimmune thyroid disease20	9.5	CD40LG, HLA-DPB1, IFNA2, HLA-DQB1, TG, TPO
11	PGC1Alpha Pathway36	9.5	IL10RB, IL4R, TNFRSF1B, TNFRSF1A, IL2RB, IL1B
12	Immune response_IL-12 signaling pathway41	9.5	STAT3, IFNG, IL2RA, IL18R1, IRF1, IL12RB2
13	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	IL2RA, TNF, TNFRSF1A, TNFRSF1B, IL2RB
14	Hepatitis C20	9.3	STAT3, IFNB1, STAT1, TNFRSF1A, EIF2AK2, TNF
15	Immune System38	9.3	IFIH1, IFNAR2, ICAM1, CD79A, STAT2, ISG20
16	Staphylococcus aureus infection20	9.2	CFB, ICAM1, HLA-DPB1, HLA-DQB1, C3, HLA-DRB1
17	NF-kappaB Signaling3	9.1	TNFRSF1B, IRF1, IRF2, IL1B, IFIH1, TNF
18	Immune response IL-22 signaling pathway10	9.0	IL2RB, STAT3, HLA-DRB1, STAT1, CD4, IL10RB
19	Immune response_IL-22 signaling pathway41	9.0	CD4, IL10RB, IL2RA, IL12RB2, STAT1, HLA-DPB1
20	IL-9 Pathway36	9.0	TNF, TNFRSF1B, STAT3, STAT1, TNFRSF1A
21	Molecular Mechanisms of Cancer36	9.0	TNFRSF1B, FADD, IL6, IL4R, IL12RB2, IL10RB
22	Th1 Differentiation37	8.9	STAT3, TNF, IFNG, IL18R1, CD4, IL12RB2
23	Allograft rejection20	8.8	TNF, HLA-DQB1, HLA-DPB1, IFNG, HLA-DRB1, CD40LG
24	Interferon Pathway36	8.8	IFNAR2, IFNB1, STAT1, STAT2, IFNG, IFNA2
25	Osteoclast differentiation20	8.7	TNFRSF1A, IRF9, IL1B, IFNAR2, IFNB1, IFNG
26	Type I diabetes mellitus20	8.5	IL1B, HLA-DPB1, IFNG, TNF, HLA-DRB1, HLA-DQB1
27	Leishmaniasis20	8.5	IL1B, IFNG, HLA-DPB1, HLA-DQB1, HLA-DRB1, TNF
28	Toxoplasmosis20	8.4	CD40LG, STAT3, IL10RB, IFNG, HLA-DPB1, HLA-DQB1
29	Toll-like receptor signaling pathway20	8.4	IL1B, IL6, IFNB1, IFNAR2, FADD, TNF
30	JNK Pathway36	8.3	TNFRSF1A, IL6, IL2RB, IL2RA, CD4, IL18R1
31	Tec Kinases Signaling36	8.3	STAT3, IL6, STAT1, STAT2, IL10RB, IL12RB2
32	Cytokine Network36	8.2	IL1B, IFNA2, IL6, IFNB1, IFNG, TNF
33	Glucocorticoid Receptor Signaling36	8.2	IL10RB, IL18R1, IL1B, IL2RA, IL4R, IL6
34	THC Differentiation Pathway36	8.1	IL2RA, IL12RB2, TNF, TNFRSF1B, HLA-DQB1, IL10RB
35	Akt Signaling36	8.1	TNFRSF1A, IL2RA, IL2RB, IL4R, IL6, TNF
36	TGF-Beta Pathway36	8.1	IL1B, IL10RB, IL18R1, IL2RA, IL2RB, IL4R
37	Chagas disease (American trypanosomiasis)20	7.8	IL1B, IFNB1, TNFRSF1A, FADD, IFNG, TNF
38	Jak-STAT signaling pathway20	7.8	STAT2, IL10RB, STAT1, STAT3, TPO, IRF9
39	Hematopoietic cell lineage20	7.7	IL1B, CD4, IL2RA, IL4R, IL6, HLA-DRB1
40	Malaria20	7.7	IL6, IL1B, IFNG, ICAM1, TNF, CD40LG
41	Measles20	7.6	IRF9, IFNB1, IFNAR2, IFNA2, IFIH1, IL6
42	Rheumatoid arthritis20	7.5	HLA-DRB1, IL1B, IL6, IFNG, ICAM1, HLA-DPB1
43	Antioxidant Action of Vitamin-C36	7.4	IL1B, IL6, TNF, TNFRSF1A, TNFRSF1B, CXCL10
44	MAPK Family Pathway36	7.4	TNFRSF1B, IL4R, IL1B, IL12RB2, IL18R1, IL10RB
45	STAT3 Pathway36	7.2	IL2RA, CXCL10, CD4, IL10RB, IL12RB2, IL18R1
46	p38 Signaling36	7.2	CXCL10, TNFRSF1A, IL12RB2, TNF, CD4, STAT1
47	JAK-STAT Pathway36	7.0	IL2RB, IL2RA, IL1B, IL18R1, IL10RB, CD4
48	Tuberculosis20	7.0	IFNG, IL6, TNFRSF1A, TNF, HLA-DRB1, HLA-DQB1
49	Influenza A20	6.6	STAT2, TNFRSF1A, TNF, HLA-DRB1, HLA-DQB1, HLA-DPB1
50	Cytokine-cytokine receptor interaction20	6.5	IL10RB, CD40LG, IL1B, IL2RA, IL2RB, IL4R

Compounds related to mumps according to GeneDecks:

(show top 50)    (show all 242)

id	Compound	Score	Top Affiliating Genes
1	polyethylene glycol32	10.3	MBP, NEU1, IFNA2
2	gamma globulin32	10.0	TG, CD79A
3	pge232	10.0	CD4, IRF1, IL1RN, TNFRSF1B, STAT1, CXCL10
4	ivig32	9.3	IFNB1, CRP, TG, MBP, IL18R1
5	gliadin32	9.3	STAT1, IRF1, CD40LG, CD79A, TG, TPO
6	ribavirin32 34 9 9	12.2	STAT3, IFNA2, EIF2AK2, IFNG, IFNB1, ISG20
7	heparin32 9 18 9	12.2	PDP1, MBP, CD79A, UMOD, IL18R1, IL1RN
8	endotoxin32	9.2	IL18R1, IL2RB, IFNB1, HSF1, TNFRSF1A, TNFRSF1B
9	n acetylcysteine32	9.0	CD79A, IL2RA, IL2RB, MBP, IGHE, HSF1
10	estrogen32	8.7	HSF1, IGHE, MBP, IL1RN, AURKA, C3
11	cuprophan32	8.6	ICAM1, IL1B, IL2RA, IL1RN, TNFRSF1B, IL2RB
12	aspartate32	8.6	TPO, EIF2AK2, TG, STAT3, IFNB1, AURKA
13	chloroquine32 34 9 9	11.4	CD4, IL1RN, IL2RA, EIF2AK2, IFNB1, TNF
14	ifn-alpha32	8.0	STAT2, STAT3, STAT1, CXCL10, EIF2AK2, IFNG
15	sulfasalazine32 9 9	10.0	CD40LG, IL2RA, IL1RN, IL1B, CD79A, TNF
16	oligonucleotide32	8.0	FADD, ISG20, CD4, IRF1, STAT1, HSF1
17	vegf32	7.9	TG, CRP, TNFRSF1B, TNFRSF1A, HSPB1, ICAM1
18	poly(i-c)32	7.9	IFNB1, TNF, CXCL10, STAT1, EIF2AK2, IL1B
19	cysteine32	7.9	MBP, IFNA2, IFNG, FADD, HSF1, TPO
20	cisplatin32 34 9 9	10.8	TNFRSF1B, HSPB1, TNFRSF1A, STAT1, MBP, STAT3
21	polysaccharide32	7.8	MRC1, CD79A, CD4, CD40LG, CD46, IL18R1
22	h2o232	7.8	IFNB1, CD79A, IL1RN, IL2RA, MBP, STAT1
23	polyinosinic-polycytidylic acid32	7.7	IRF1, IL1B, IFIH1, IFNB1, IFNG, TNF
24	2,5-oligoadenylate32	7.6	ISG20, IRF1, IRF2, IRF9, IL2RA, IL2RB
25	thalidomide32 42 9 9	10.5	TNFRSF1A, IFNG, TNFRSF1B, STAT3, IFNA2, IL6
26	cyclosporin a32 42	8.5	STAT1, STAT3, CD46, IL18R1, IL1RN, IL2RA
27	sb 20358032 42	8.5	STAT1, STAT3, EIF2AK2, IRF1, IL6, IFNB1
28	il 1032	7.2	IL4R, IL6, IFNB1, IFNG, TNF, TNFRSF1B
29	etanercept32 9 9	9.0	IL18R1, IL1B, IL1RN, IL2RB, IL6, IFNA2
30	okt332	6.9	TNF, TNFRSF1A, CRP, ICAM1, CD79A, CD40LG
31	rantes32	6.9	CD4, CD40LG, CD46, CXCL10, IRF1, IL18R1
32	herbimycin a32 42	7.8	HSF1, TNF, STAT1, ICAM1, IFNG, IFNB1
33	serine32	6.3	IFNB1, HSF1, HSPB1, TNF, TNFRSF1A, TNFRSF1B
34	actinomycin d32	6.3	IL4R, IL6, STAT1, STAT3, FADD, IGHE
35	prednisolone32 9 9	8.2	CD79A, IL18R1, IL1RN, IL2RA, IL2RB, IL6
36	histamine32 18	7.2	NEU1, ICAM1, TNF, CXCL10, IL4R, IFNG
37	infliximab32 9 9	8.2	IGHE, IFNA2, IFNG, TNF, TNFRSF1A, TNFRSF1B
38	thymidine32 18	7.1	IL1B, IL4R, IRF1, IL18R1, IL6, IFNB1
39	nitric oxide32 9 18 9	9.1	EIF2AK2, TPO, TNFRSF1B, HSF1, TNFRSF1A, ICAM1
40	creatinine32	6.0	UMOD, CD79A, CD40LG, C3, CXCL10, TG
41	indomethacin32 9 9	8.0	CD79A, STAT1, CD40LG, IL1B, IL1RN, IL2RA
42	genistein32 9 18 9	8.9	CD4, CD40LG, CXCL10, STAT1, STAT3, IRF9
43	methotrexate32 34 42 9 9	9.6	CRP, TNFRSF1B, CD79A, IL1B, IL1RN, IL2RA
44	lipid32	5.2	STAT1, TNFRSF1B, CRP, CXCL10, IL1RN, C3
45	alanine32	5.2	CD79A, CD4, CD40LG, CD46, IL18R1, IL1RN
46	neopterin32	5.2	CD79A, CD4, CD40LG, IL18R1, IL1B, IL1RN
47	dexamethasone32 42 34 9 9	8.9	CD79A, CD40LG, CD46, IL18R1, IL1B, IL1RN
48	tyrosine32	4.7	TG, STAT3, STAT1, CXCL10, MBP, IFNA2
49	retinoic acid32 42 18	6.2	IL18R1, TNFRSF1B, EIF2AK2, TG, STAT2, STAT3
50	cycloheximide32	3.7	HSPB1, IL1RN, IL1B, IRF9, IRF2, IRF1

Cellular components related to mumps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.7	HLA-DRB1, HLA-DQB1, HLA-DPB1
2	lysosomal membrane	GO:005765	9.5	HLA-DPB1, HLA-DQB1, HLA-DRB1, OCA2, NEU1
3	membrane raft	GO:045121	9.0	TNFRSF1B, TNFRSF1A, TNF, FADD, CD4, CD79A
4	integral to plasma membrane	GO:005887	8.0	TNFRSF1A, TNF, TPO, HLA-DRB1, ICAM1, IFNAR2
5	cytosol	GO:005829	8.0	STAT1, STAT3, STAT2, EIF2AK2, COPE, HSPB1
6	external side of plasma membrane	GO:009897	7.9	CXCL10, TNF, HLA-DRB1, ICAM1, IFNG, IL2RB
7	extracellular region	GO:005576	6.6	TNFRSF1A, TNFRSF1B, CRP, TG, CXCL10, C3
8	extracellular space	GO:005615	5.9	UMOD, C3, CXCL10, DPT, CRP, TNFRSF1A
9	plasma membrane	GO:005886	5.4	TPO, HLA-DRB1, HLA-DQB1, HLA-DPB1, HSPB1, TNF

Biological processes related to mumps according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of type I interferon-mediated signaling pathway	GO:060338	10.4	STAT1, STAT2, IFNB1, IFNAR2, IFNA2
2	JAK-STAT cascade	GO:007259	10.3	STAT1, STAT3, STAT2, IFNAR2
3	regulation of complement activation	GO:030449	10.2	C3, CD46, CFB
4	type I interferon-mediated signaling pathway	GO:060337	10.1	IRF1, IRF2, IRF9, IFNA2, IFNAR2, IFNB1
5	negative regulation of T-helper 2 cell cytokine production	GO:2000552	10.1	IFNA2, IFNB1
6	chronic inflammatory response to antigenic stimulus	GO:002439	10.1	IL1RN, IL1B
7	B cell proliferation	GO:042100	10.0	IFNB1, CD40LG, CD79A
8	virus-host interaction	GO:019048	9.7	STAT1, STAT3, STAT2, EIF2AK2, TNFRSF1A, IFIH1
9	cellular response to mechanical stimulus	GO:071260	9.7	IRF1, IL1B, FADD, TNFRSF1A
10	negative regulation of metanephric nephron tubule epithelial cell differentiation	GO:072308	9.6	STAT1, IFNG
11	innate immune response	GO:045087	9.6	C3, IFNB1, IFNA2, IFIH1, FADD, IL18R1
12	positive regulation of interferon-gamma production	GO:032729	9.5	TNF, IL1B, IL12RB2, CD40LG
13	regulation of I-kappaB kinase/NF-kappaB cascade	GO:043122	9.5	TNF, HSPB1, IL1B
14	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	TNF, IFNG
15	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.3	TNF, IFNG, IL1B
16	positive regulation of chemokine biosynthetic process	GO:045080	9.2	TNF, IFNG, IL1B
17	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.2	TNFRSF1B, TNF, IFNG, IL1B
18	interferon-gamma-mediated signaling pathway	GO:060333	9.1	STAT1, IRF1, IRF2, IRF9, IFNG, ICAM1
19	cell surface receptor signaling pathway	GO:007166	9.1	CXCL10, IFNG, IFNB1, IFNAR2, IFNA2, IL2RA
20	defense response to virus	GO:051607	9.0	CXCL10, IFNG, IFNB1, FADD, IL6, IRF1
21	positive regulation of nitric oxide biosynthetic process	GO:045429	8.9	TNF, ICAM1, IFNG, IL1B
22	response to virus	GO:009615	8.8	HSPB1, TNF, EIF2AK2, STAT2, STAT1, IFNG
23	negative regulation of lipid storage	GO:010888	8.8	CRP, TNF, IL6
24	acute-phase response	GO:006953	8.7	STAT3, CRP, IL6, IL1RN
25	humoral immune response	GO:006959	8.5	IL6, IFNB1, IFNG, TNF
26	negative regulation of cell proliferation	GO:008285	8.4	DPT, EIF2AK2, TNF, HSF1, IFNB1, IL6
27	immune response	GO:006955	8.1	IGHE, HLA-DQB1, HLA-DRB1, CXCL10, C3, MBP
28	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.5	STAT1, STAT3, TNFRSF1A, TNF, IFNG, IFNB1
29	inflammatory response	GO:006954	7.5	C3, CXCL10, CRP, TNFRSF1B, TNFRSF1A, TNF
30	cytokine-mediated signaling pathway	GO:019221	6.7	ISG20, ICAM1, HLA-DPB1, HLA-DQB1, HLA-DRB1, TNFRSF1A

Molecular functions related to mumps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulatory region DNA binding	GO:000975	10.2	IRF9, IRF2, IRF1
2	tumor necrosis factor receptor binding	GO:005164	9.6	CD40LG, FADD, TNF, STAT1
3	receptor activity	GO:004872	9.5	IL18R1, IL10RB, CD46, CD4, MRC1, ICAM1
4	cytokine activity	GO:005125	7.8	CD40LG, TNF, IFNG, IFNB1, IFNA2, IL6
5	protein binding	GO:005515	5.7	HSF1, HSPB1, TNF, TNFRSF1A, TNFRSF1B, CRP