MCID: MMP001
MIFTS: 51

Mumps malady

Rare diseases, Infectious diseases, Oral diseases categories

Summaries for Mumps

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MedlinePlus:32 Mumps is an illness caused by the mumps virus. it starts with fever headache muscle aches tiredness loss of appetite after that, the salivary glands under the ears or jaw become swollen and tender. the swelling can be on one or both sides of the face. symptoms last 7 to 10 days. serious complications are rare. you can catch mumps by being with another person who has it. there is no treatment for mumps, but the measles-mumps-rubella (mmr) vaccine can prevent it. before the routine vaccination program in the united states, mumps was a common illness in infants, children and young adults. now it is a rare disease in the u.s. centers for disease control and prevention

MalaCards based summary: Mumps is related to measles and hepatitis, and has symptoms including fever, headache and muscle aches. An important gene associated with Mumps is STAT2 (signal transducer and activator of transcription 2, 113kDa), and among its related pathways are NF-kappaB Signaling and CXCR4-mediated signaling events. The compounds mumps and gliadin have been mentioned in the context of this disorder. Affiliated tissues include salivary gl, salivary gland and brain, and related mouse phenotypes are integument and skeleton.

Disease Ontology:9 A viral infectious disease that results in inflammation located in salivary gland, has material basis in mumps virus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. the infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

CDC:3 Mumps is a contagious disease that is caused by the mumps virus. Mumps typically starts with a few days of fever, headache, muscle aches, tiredness, and loss of appetite, and is followed by swelling of salivary glands. Anyone who is not immune from either previous mumps infection or from vaccination can get mumps.

Wikipedia:63 Mumps, also known as epidemic parotitis, is a viral disease caused by the mumps virus. Initial signs and... more...

Aliases & Classifications for Mumps

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Mumps, Aliases & Descriptions:

Name: Mumps 9 41 11 43 32 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology9 DOID:10264
MeSH33 D009107
NCIt38 C29888
ICD9CM27 072
ICD1025 B26, B26.8, B26.9

Related Diseases for Mumps

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Graphical network of the top 20 diseases related to Mumps:



Diseases related to mumps

Symptoms for Mumps

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Symptoms:

 9
  • fever
  • headache
  • muscle aches
  • tiredness
  • loss of appetite
  • swollen

Drugs & Therapeutics for Mumps

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Drug clinical trials:

Search ClinicalTrials for Mumps

Search NIH Clinical Center for Mumps

Genetic Tests for Mumps

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Anatomical Context for Mumps

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MalaCards organs/tissues related to Mumps:

31
Salivary gland, Brain, Testes, B cells, Thyroid, Skin, T cells, Endothelial, Bone marrow, Bone, Myeloid

FMA organs/tissues related to Mumps:

14
Salivary gl

Animal Models for Mumps or affiliated genes

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MGI Mouse Phenotypes related to Mumps:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5STAT1, IRF2, IRF1, NEU1
2MP:00053907.8CFB, NEU1, IRF1, STAT1
3MP:00053977.7NEU1, IRF1, IRF2, STAT2, STAT1, IFNAR2
4MP:00107687.6NEU1, IRF1, IRF2, STAT2, STAT1, IFNAR2
5MP:00053876.9IFNAR2, CFB, NEU1, IRF1, IRF2, STAT2

Publications for Mumps

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Articles related to Mumps:

(show top 50)    (show all 697)
idTitleAuthorsYear
1
Seroprevalence of measles, mumps and rubella among young adults, after 20A years of universal two-dose MMR vaccination in Israel. (25891446)
2015
2
Measles-Mumps-Rubella-Varicella Combination Vaccine (ProQuad(Ar)): A Guide to Its Use in Children in the EU. (25732634)
2015
3
Mumps outbreak in the Federation of Bosnia and Herzegovina with large cohorts of susceptibles and genetically diverse strains of genotype G, Bosnia and Herzegovina, December 2010 to September 2012. (25166347)
2014
4
Mumps serum antibody levels before and after an outbreak to assess infection and immunity in vaccinated students. (25734169)
2014
5
Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. (24313836)
2014
6
Mumps antibody response in young adults after a third dose of measles-mumps-rubella vaccine. (25734162)
2014
7
Mumps vaccine effectiveness and risk factors for disease in households during an outbreak in New York City. (24252695)
2014
8
Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles-mumps-rubella. (24412300)
2014
9
Seroprevalence survey on measles, mumps, rubella and varicella antibodies in healthcare workers in Japan: sex, age, occupational-related differences and vaccine efficacy. (23574767)
2014
10
Risk Factors for Transmission of Mumps in a Highly Vaccinated Population in Orange County, NY, 2009-2010. (23995590)
2014
11
Investigation of an outbreak of hypersensitivity-type reactions during the 2004 national measles-mumps-rubella vaccination campaign in Brazil. (23246259)
2013
12
Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan. (24270137)
2013
13
Outbreak-related mumps vaccine effectiveness among a cohort of children and of young adults in Germany 2011. (24091837)
2013
14
Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage. (23661802)
2013
15
Characterisation of mumps virus genotype C among patients with mumps in India. (23883719)
2013
16
Spermiogram part of population with the manifest orchitis during an ongoing epidemic of mumps. (22937687)
2012
17
Establishment of a standard seed lot system of an Iranian Mumps virus strain; RS-12, for mass production of mumps and MMR vaccines. (23115712)
2012
18
Seroepidemiology of mumps in Europe (1996-2008): why do outbreaks occur in highly vaccinated populations? (22687578)
2012
19
Acupuncture for mumps in children. (22972121)
2012
20
Pityriasis lichenoides et varioliformis acuta: a rare association with the measles, mumps and rubella vaccine. (23157791)
2012
21
Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. (23217121)
2012
22
Mumps exposure of a health care provider working in a neonatal intensive care unit leads to a hospital-wide effort that prevented an outbreak. (21641085)
2011
23
Mumps virus encephalitis with symmetric claustrum lesions. (21659481)
2011
24
A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein. (20727167)
2010
25
Lower long-term immunogenicity of mumps component after MMR vaccine. (20975455)
2010
26
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
27
Closer look at autism and the measles-mumps-rubella vaccine. (21071320)
2010
28
Mumps vaccine effectiveness in highly immunized populations. (20226249)
2010
29
Role of laboratory in rapid diagnosis of atypical mumps. (20563452)
2010
30
Molecular differences between two Jeryl Lynn mumps virus vaccine component strains, JL5 and JL2. (19656963)
2009
31
An office-based prospective study of deafness in mumps. (19209100)
2009
32
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. (19007835)
2009
33
Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. (19625458)
2009
34
Mumps: not an innocent bystander in solid organ transplantation. (19563333)
2009
35
Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial. (19366435)
2009
36
Mumps outbreak on the island of Anglesey, North Wales, December 2008-January 2009. (19215718)
2009
37
Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. (18440578)
2008
38
Detection of mumps virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform. (18945836)
2008
39
The role of air travel in the spread of mumps. (18831704)
2008
40
Mumps outbreak in a highly vaccinated school population: assessment of secondary vaccine failure using IgG avidity measurements. (17498856)
2007
41
Assessing participation bias in a population-based study of measles-mumps-rubella vaccine immunity in children and adolescents aged 12-18. (17564596)
2007
42
Comparison of the safety and immunogenicity of a refrigerator-stable versus a frozen formulation of ProQuad (measles, mumps, rubella, and varicella virus vaccine live). (17502347)
2007
43
Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)
2005
44
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
45
Mumps epididymo-orchitis with prolonged detection of virus in semen and the development of anti-sperm antibodies. (15042662)
2004
46
The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997. (12435771)
2002
47
Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies. (10390298)
1999
48
Mumps pancreatitis without parotitis. (4692679)
1973
49
LEUKEMOID REACTION TO MUMPS VIRUS. (14160741)
1964
50
Mumps meningoencephalitis with and without parotitis. (18147966)
1949

Variations for Mumps

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Expression for genes affiliated with Mumps

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Search GEO for disease gene expression data for Mumps.

Pathways for genes affiliated with Mumps

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Pathways related to Mumps according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IRF2, IRF1
29.6STAT1, STAT2
3
Show member pathways
IL27-mediated signaling events36
9.6STAT2, STAT1
4
Show member pathways
9.6STAT1, STAT2
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.6STAT2, STAT1
6
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.6STAT1, IRF1
7
Show member pathways
Immune response MIF in innate immunity response58
9.6STAT1, IRF1
89.6IRF1, STAT1
99.6IRF1, STAT1
109.6IFNAR2, IRF1
11
Show member pathways
9.2IFNA2, IRF1, IRF2
129.2IRF2, IFNA2, IRF1
13
Show member pathways
9.2IRF1, IRF2, IFNA2
14
Show member pathways
IFN-gamma pathway36
9.2STAT1, STAT2, IRF1
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1IFNA2, STAT1, IRF1
169.1STAT1, STAT2, IFNAR2
179.1IFNAR2, STAT1, STAT2
188.6STAT1, IFNA2, STAT2, IFNAR2
19
Show member pathways
Type III interferon signaling36
8.6STAT1, STAT2, IFNAR2, IFNA2
20
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6IFNA2, STAT1, STAT2, IFNAR2
21
Show member pathways
8.6IFNAR2, STAT2, STAT1, IFNA2
22
Show member pathways
8.6IFNAR2, STAT2, STAT1, IFNA2
238.4IRF1, STAT2, STAT1, IFNA2, IRF2
248.3IFNAR2, IFNA2, STAT1, IRF1, STAT2
25
Show member pathways
7.8IRF1, IFNAR2, STAT2, IRF2, STAT1, IFNA2
26
Show member pathways
7.8IRF1, IFNA2, IFNAR2, STAT2, STAT1, IRF2

Compounds for genes affiliated with Mumps

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Compounds related to Mumps according to GeneCards Suite gene sharing:

(show all 30)
idCompoundScoreTop Affiliating Genes
1mumps4310.0STAT1, STAT2
2gliadin439.9IRF1, STAT1
3indoleamine439.9STAT1, IRF1
4inosine monophosphate439.8IRF1, STAT1
5deferoxamine43 1210.8STAT1, IRF1
6imiquimod43 59 28 1212.8IFNA2, STAT1
7polyinosinic-polycytidylic acid439.8STAT1, IRF1
8amantadine43 1210.7IFNA2, NEU1
9suberoylanilide hydroxamic acid439.7IRF1, STAT1
10levamisole43 1210.7NEU1, IFNA2
11acyclovir43 1210.7IFNA2, NEU1
12poly(i-c)439.7STAT1, IRF1
13con a439.6IFNA2, NEU1
14vanadate439.6STAT1, STAT2
15retinoid439.4IRF1, STAT1, IFNA2
16etoposide43 49 59 1212.4IRF1, STAT1, IFNA2
17galactose439.4IFNA2, NEU1
18zidovudine43 49 1211.3NEU1, IFNA2
19cellulose acetate439.3NEU1, CFB
20ribavirin43 49 1211.2NEU1, STAT1, IFNA2
21polyethylene glycol439.1IFNA2, NEU1
22agarose438.9CFB, NEU1, IFNA2
23cycloheximide438.9STAT1, IRF2, IRF1, NEU1
24estrogen438.8NEU1, IRF1, STAT1, IFNA2
25lipid438.7IRF1, STAT1, IFNA2, IFNAR2
26ifn-alpha438.6IRF1, STAT2, STAT1, IFNA2, IFNAR2
272,5-oligoadenylate438.2IFNAR2, IFNA2, STAT1, STAT2, IRF2, IRF1
28tyrosine438.2IRF1, IRF2, STAT2, STAT1, IFNA2, IFNAR2
29serine437.8CFB, NEU1, IRF1, IRF2, STAT2, STAT1
30retinoic acid43 248.6NEU1, IRF1, IRF2, STAT2, STAT1, IFNA2

GO Terms for genes affiliated with Mumps

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Cellular components related to Mumps according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.6STAT1, IRF1
2nucleoplasmGO:00056548.5STAT1, STAT2, IRF2, IRF1

Biological processes related to Mumps according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interferon-betaGO:00354589.6IRF1, STAT1
2interferon-gamma-mediated signaling pathwayGO:00603339.2STAT1, IRF1, IRF2
3JAK-STAT cascadeGO:00072599.2IFNAR2, STAT1, STAT2
4apoptotic processGO:00069159.1STAT1, IFNA2, IRF1
5regulation of transcription from RNA polymerase II promoterGO:00063579.0STAT1, STAT2, IFNAR2
6blood coagulationGO:00075968.9IFNA2, IRF2, IRF1
7defense response to virusGO:00516078.9STAT2, STAT1, IFNA2, IRF1
8regulation of type I interferon-mediated signaling pathwayGO:00603388.8STAT2, STAT1, IFNAR2, IFNA2
9type I interferon signaling pathwayGO:00603378.1IFNAR2, IFNA2, STAT1, IRF1, IRF2, STAT2
10cytokine-mediated signaling pathwayGO:00192218.0IFNA2, STAT1, STAT2, IRF2, IRF1, IFNAR2

Molecular functions related to Mumps according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.6STAT1, IRF1
2sequence-specific DNA binding transcription factor activityGO:00037008.5STAT1, STAT2, IRF2, IRF1

Products for genes affiliated with Mumps

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Sources for Mumps

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3CDC
13ExPASy
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23HGMD
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet