MCID: MNG003
MIFTS: 34

Mungan Syndrome

Categories: Rare diseases, Genetic diseases, Neuronal diseases, Gastrointestinal diseases

Aliases & Classifications for Mungan Syndrome

MalaCards integrated aliases for Mungan Syndrome:

Name: Mungan Syndrome 53 49 13 69
Mgs 53 49
Visceral Neuromyopathy, Familial, with Pseudoobstruction, Megaduodenum, Barrett Esophagus, and Cardiac Abnormalities 53
Visceral Neuromyopathy Familial with Pseudoobstruction Megaduodenum Barrett Esophagus and Cardiac Abnormalities 49
Pseudoobstruction, Chronic Idiopathic Intestinal, with Barrett Esophagus and Cardiac Abnormalities 53
Pseudoobstruction Chronic Idiopathic Intestinal with Barrett Esophagus and Cardiac Abnormalities 49

Characteristics:

OMIM:

53
Inheritance:
autosomal recessive


HPO:

31
mungan syndrome:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Mungan Syndrome

MalaCards based summary : Mungan Syndrome, also known as mgs, is related to myasthenia gravis and primary hypomagnesemia, and has symptoms including vesicoureteral reflux, renal hypoplasia and pulmonic stenosis. An important gene associated with Mungan Syndrome is MGS (Mungan Syndrome).

Wikipedia : 72 Mungan syndrome is first described in 2003 by Mungan Z. et al. as an autosomal recessively inherited... more...

Description from OMIM: 611376

Related Diseases for Mungan Syndrome

Diseases related to Mungan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 myasthenia gravis 11.9
2 primary hypomagnesemia 11.3
3 myasthenia gravis congenital 11.3
4 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.1
5 morning glory syndrome 11.1
6 visceral myopathy 11.0
7 hypomagnesemia 3, renal 10.9
8 fetal methylmercury syndrome 10.9
9 maturity-onset diabetes of the young, type 2 10.8
10 anencephaly 10.8
11 hyperphenylalaninemia, bh4-deficient, b 10.8
12 hyperphenylalaninemia, bh4-deficient, a 10.8
13 kearns-sayre syndrome 10.8
14 glut1 deficiency syndrome 1 10.8
15 crigler-najjar syndrome, type ii 10.8
16 aromatase deficiency 10.8
17 adenine phosphoribosyltransferase deficiency 10.8
18 mild phenylketonuria 10.8
19 paroxysmal hemicrania 10.8
20 astrocytoma 10.1
21 hypercholesterolemia, autosomal dominant, 3 10.1
22 prostatitis 10.0
23 major depressive disorder 10.0
24 rosacea 10.0
25 glioblastoma 10.0
26 glioma 10.0
27 aging 10.0
28 candidiasis 10.0
29 pyelonephritis 9.9
30 tinea pedis 9.9
31 episodic pain syndrome, familial, 1 9.9
32 alopecia 9.9
33 androgenic alopecia 9.9
34 acute pyelonephritis 9.9
35 alopecia, androgenetic, 1 9.9
36 myocardial infarction 9.9
37 vaginitis 9.9
38 vulvovaginal candidiasis 9.9
39 vulvovaginitis 9.9
40 precocious puberty 9.9
41 prostate cancer 9.8
42 hydrops, lactic acidosis, and sideroblastic anemia 9.8
43 macular retinal edema 9.8
44 central precocious puberty 9.8
45 blood group, i system 9.8
46 osteoporosis 9.8
47 schizophrenia 9.8
48 bone mineral density quantitative trait locus 8 9.8
49 bone mineral density quantitative trait locus 15 9.8
50 leukemia 9.8

Graphical network of the top 20 diseases related to Mungan Syndrome:



Diseases related to Mungan Syndrome

Symptoms & Phenotypes for Mungan Syndrome

Symptoms via clinical synopsis from OMIM:

53
Genitourinary Ureters:
vesicoureteral reflux

Head And Neck Eyes:
ptosis, bilateral

Cardiovascular Vascular:
supravalvular pulmonary stenosis, minimal

Neurologic Peripheral Nervous System:
visceral neuromyopathy

Genitourinary Kidneys:
renal hypoplasia

Cardiovascular Heart:
tricuspid valve regurgitation
ventricular septal defect, membranous
pulmonary valve regurgitation
pulmonary valve stenosis, minimal

Abdomen Gastroin testinal:
visceral neuromyopathy
pseudoobstruction
megaduodenum
barrett esophagus, long-segment
aperistalsis


Clinical features from OMIM:

611376

Human phenotypes related to Mungan Syndrome:

31 (show all 11)
# Description HPO Frequency HPO Source Accession
1 vesicoureteral reflux 31 HP:0000076
2 renal hypoplasia 31 HP:0000089
3 pulmonic stenosis 31 HP:0001642
4 tricuspid regurgitation 31 HP:0005180
5 intestinal pseudo-obstruction 31 HP:0004389
6 abnormality of the autonomic nervous system 31 HP:0002270
7 bilateral ptosis 31 HP:0001488
8 hypoperistalsis 31 HP:0100771
9 perimembranous ventricular septal defect 31 HP:0011682
10 barrett esophagus 31 HP:0100580
11 megaduodenum 31 HP:0030996

Drugs & Therapeutics for Mungan Syndrome

Search Clinical Trials , NIH Clinical Center for Mungan Syndrome

Genetic Tests for Mungan Syndrome

Anatomical Context for Mungan Syndrome

Publications for Mungan Syndrome

Articles related to Mungan Syndrome:

(show top 50) (show all 632)
# Title Authors Year
1
Effects of Mg Addition with Natural Aging Time on Two-Step Aging Behavior in Al-Mg-Si Alloys. ( 29448743 )
2018
2
Progression-free survival results in postmenopausal Asian women: subgroup analysis from a phase III randomized trial of fulvestrant 500A mg vs anastrozole 1A mg for hormone receptor-positive advanced breast cancer (FALCON). ( 29450827 )
2018
3
Extended Treatment with Single-Agent Ibrutinib at the 420 mg Dose Leads to Durable Responses in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. ( 28073846 )
2017
4
A pro-angiogenic degradable Mg-poly(lactic-co-glycolic acid) implant combined with rhbFGF in a rat limb ischemia model. ( 28951330 )
2017
5
Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use. ( 29038072 )
2017
6
Dantrolene requires Mg(2+) to arrest malignant hyperthermia. ( 28373535 )
2017
7
Simulating the fidelity and the three Mg mechanism of pol I^ and clarifying the validity of transition state theory in enzyme catalysis. ( 28383109 )
2017
8
Benefits of Statin Therapy in Patients With Acute Myocardial Infarction With Serum Low-Density Lipoprotein Cholesterol a8o 50A mg/dl. ( 28532771 )
2017
9
Treatment efficacy of azithromycin 1A g single dose versus doxycycline 100A mg twice daily for 7A days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. ( 28061753 )
2017
10
Efficacy and Safety of Terbinafine 500 mg Once Daily in Patients with Dermatophytosis. ( 28794551 )
2017
11
Meta-Analysis of Paediatric Patients with Central Precocious Puberty Treated with Intramuscular Triptorelin 11.25 mg 3-Month Prolonged-Release Formulationa8c. ( 28334719 )
2017
12
Control of lice infestation in horses using a 10 mg/mL deltamethrin topical application. ( 28649361 )
2017
13
Ethinylestradiol 20A I1g/drospirenone 3A mg in a flexible extended regimen for the management of endometriosis-associated pelvic pain: a randomized controlled trial. ( 28911925 )
2017
14
Rational for Drug Dosimetry and Duration of Terbinafine in the Context of Recalcitrant Dermatophytosis: Is 500 mg Better than 250 mg OD or BD? ( 29263545 )
2017
15
Vonoprazan 10 mg daily is effective for the treatment of patients with proton pump inhibitor-resistant gastroesophageal reflux disease. ( 28894571 )
2017
16
Antia89inflammatory actions of gabapentin and pregabalin on the substance Pa89induced mitogena89activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. ( 28849160 )
2017
17
Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750A mg/day) or conventional intravenous/oral levofloxacin (500A mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. ( 28108978 )
2017
18
The RING finger- and PDZ domain-containing protein PDZRN3 controls localization of the Mg(2+) regulator claudin-16 in renal tube epithelial cells. ( 28623232 )
2017
19
Disease Control on Lanreotide AutogelAr 120 mg in a Patient with Metastatic Gastrinoma: A Case Report. ( 29430219 )
2017
20
Ingenol Mebutate 150 mg as Physician-Directed Treatment of Bowen's Disease Under Occlusion. ( 27512986 )
2016
21
The efficacy of febuxostat 10 mg for the prevention of hyperuricemia associated with tumor lysis syndrome (TLS) in Japanese patients with non-Hodgkin's lymphomaa8c. ( 27641217 )
2016
22
Adding a single low-dose of primaquine (0.25A mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial. ( 27565897 )
2016
23
Treatment of CNV secondary to presumed ocular histoplasmosis with intravitreal aflibercept 2.0 mg injection. ( 27085265 )
2016
24
The effect of 1A mg folic acid supplementation on clinical outcomes in female migraine with aura patients. ( 27339806 )
2016
25
Effect of topical simvastatin (1.2A mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - A clinicobiochemical study. ( 27195204 )
2016
26
Human CNNM2 is not a Mg(2+) transporter per se. ( 27068403 )
2016
27
MG-QoL-15 scores in treated myasthenia gravis: Experience from a university hospital in India. ( 27147146 )
2016
28
A 6-Month Trial of the Efficacy and Safety of Triptorelin Pamoate (11.25 mg) Every 3 Months in Children with Precocious Puberty: A Retrospective Comparison with Triptorelin Acetate. ( 27603324 )
2016
29
Comparison of the Effect of Rosuvastatin 2.5A mg vs 20A mg on Coronary Plaque Determined by Angioscopy and Intravascular Ultrasound in Japanese With Stable Angina Pectoris (from the Aggressive Lipid-Lowering Treatment Approach Using Intensive Rosuvastatin for Vulnerable Coronary Artery Plaque [ALTAIR] Randomized Trial). ( 26879069 )
2016
30
QMG and MG-ADL Correlations: Study of Eculizumab Treatment of Myasthenia Gravis. ( 28010051 )
2016
31
Effectiveness of posthemodialysis administration of pregabalin (75 mg) in treatment resistance uremia pruritus. ( 26957874 )
2016
32
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
33
Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. ( 27020697 )
2016
34
Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation. ( 27160247 )
2016
35
Effect of Melphalan 140 mg/m(2) versus 200 mg/m(2) on Toxicities and Outcomes in Multiple Myeloma Patients Undergoing Single Autologous Stem Cell Transplantation - A single center experience. ( 27219740 )
2016
36
Malignant glioma with primitive neuroectodermal tumor-like component (MG-PNET): novel microarray findings in a pediatric patient. ( 27781423 )
2016
37
Topical Squalamine 0.2% and Intravitreal Ranibizumab 0.5 mg as Combination Therapy for Macular Edema Due to Branch and Central Retinal Vein Occlusion: An Open-Label, Randomized Study. ( 27759857 )
2016
38
Hypomagnesemia and functional hypoparathyroidism due to novel mutations in the Mg-channel TRPM6. ( 26273099 )
2015
39
Imatinib Mesylate-Induced Erythema Multiforme: Recurrence after Rechallenge with 200 mg/day Imatinib. ( 26512192 )
2015
40
Effect and mechanism of peroxisome proliferator-activated receptor-I^ on the drug resistance of the U-87A MG/CDDP human malignant glioma cell line. ( 25891367 )
2015
41
MicroRNAa89128a, BMI1 polycomb ring finger oncogene, and reactive oxygen species inhibit the growth of Ua8987 MG glioblastoma cells following exposure to Xa89ray radiation. ( 26238021 )
2015
42
Intravenous ceftaroline 200 mg administered every 8 h is safe and adequate for meticillin-resistant Staphylococcus aureus bloodstream infections in end-stage renal failure patients on haemodialysis: a case study. ( 26607339 )
2015
43
The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. ( 26526611 )
2015
44
Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria. ( 26038847 )
2015
45
Efficacy and safety of a single oral 150A mg dose of fluconazole for the treatment of vulvovaginal candidiasis in Japan. ( 25887336 )
2015
46
Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis. ( 25720546 )
2015
47
Effect of GnRHa 3.75 mg subcutaneously every 6 weeks on adult height in girls with idiopathic central precocious puberty. ( 25719299 )
2015
48
An observational study to monitor the efficacy and tolerability of levofloxacin 500 mg once daily for treatment of chronic bacterial prostatitis in Saudi Arabia. ( 25657549 )
2015
49
A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid: A protocol for the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Trial. ( 25683592 )
2015
50
Memantine Extended Release (28A mg Once Daily): A Review of Its Use in Alzheimer's Disease. ( 25899711 )
2015

Variations for Mungan Syndrome

Expression for Mungan Syndrome

Search GEO for disease gene expression data for Mungan Syndrome.

Pathways for Mungan Syndrome

GO Terms for Mungan Syndrome

Sources for Mungan Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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