MCID: MNG003
MIFTS: 25

Mungan Syndrome

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Mungan Syndrome

MalaCards integrated aliases for Mungan Syndrome:

Name: Mungan Syndrome 54 50 13 69
Visceral Neuromyopathy Familial with Pseudoobstruction Megaduodenum Barrett Esophagus and Cardiac Abnormalities 50
Pseudoobstruction Chronic Idiopathic Intestinal with Barrett Esophagus and Cardiac Abnormalities 50
Mgs 50

Characteristics:

OMIM:

54
Inheritance:
autosomal recessive


HPO:

32
mungan syndrome:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Mungan Syndrome

MalaCards based summary : Mungan Syndrome, also known as visceral neuromyopathy familial with pseudoobstruction megaduodenum barrett esophagus and cardiac abnormalities, is related to myasthenia gravis and primary hypomagnesemia, and has symptoms including pulmonic stenosis, vesicoureteral reflux and renal hypoplasia. An important gene associated with Mungan Syndrome is MGS (Mungan Syndrome). The drugs Anti-Infective Agents and Lactoferrin have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Wikipedia : 72 Mungan syndrome is first described in 2003 by Mungan Z. et al. as an autosomal recessively inherited... more...

Description from OMIM: 611376

Related Diseases for Mungan Syndrome

Diseases related to Mungan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
id Related Disease Score Top Affiliating Genes
1 myasthenia gravis 11.7
2 primary hypomagnesemia 11.2
3 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.0
4 morning glory syndrome 11.0
5 visceral myopathy 10.9
6 fetal methylmercury syndrome 10.8
7 hypomagnesemia 3, renal 10.8
8 myasthenia gravis congenital 10.8
9 hyperphenylalaninemia, bh4-deficient, a 10.7
10 hyperphenylalaninemia, bh4-deficient, b 10.7
11 crigler-najjar syndrome, type ii 10.7
12 aromatase deficiency 10.7
13 adenine phosphoribosyltransferase deficiency 10.7
14 mild phenylketonuria 10.7
15 kearns-sayre syndrome 10.7
16 paroxysmal hemicrania 10.7
17 anencephaly 10.7
18 glut1 deficiency syndrome 1, infantile onset, severe 10.7
19 mody, type ii 10.7
20 astrocytoma 10.0
21 prostatitis 9.9
22 rosacea 9.9
23 glioblastoma 9.9
24 glioma 9.9
25 candidiasis 9.9
26 tinea pedis 9.9
27 pyelonephritis 9.9
28 alopecia 9.8
29 acute pyelonephritis 9.8
30 myocardial infarction 9.8
31 prostate cancer 9.8
32 vaginitis 9.8
33 vulvovaginal candidiasis 9.8
34 vulvovaginitis 9.8
35 precocious puberty 9.8
36 central precocious puberty 9.8
37 croup 9.7
38 schizophrenia 9.7
39 leukemia 9.7
40 osteoporosis 9.7
41 arthritis 9.7
42 retinal vein occlusion 9.7
43 breast cancer 9.7
44 pancreatitis 9.7
45 sporotrichosis 9.7
46 hepatitis 9.7
47 rheumatoid arthritis 9.7
48 esophagitis 9.7
49 urethritis 9.7
50 acromegaly 9.7

Graphical network of the top 20 diseases related to Mungan Syndrome:



Diseases related to Mungan Syndrome

Symptoms & Phenotypes for Mungan Syndrome

Symptoms via clinical synopsis from OMIM:

54

Genitourinary- Ureters:
vesicoureteral reflux

Cardiovascular- Heart:
tricuspid valve regurgitation
ventricular septal defect, membranous
pulmonary valve regurgitation
pulmonary valve stenosis, minimal

Head And Neck- Eyes:
ptosis, bilateral

Neurologic- Peripheral Nervous System:
visceral neuromyopathy

Genitourinary- Kidneys:
renal hypoplasia

Abdomen- Gastroin testinal:
pseudoobstruction
visceral neuromyopathy
megaduodenum
barrett esophagus, long-segment
aperistalsis

Cardiovascular- Vascular:
supravalvular pulmonary stenosis, minimal


Clinical features from OMIM:

611376

Human phenotypes related to Mungan Syndrome:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 pulmonic stenosis 32 HP:0001642
2 vesicoureteral reflux 32 HP:0000076
3 renal hypoplasia 32 HP:0000089
4 tricuspid regurgitation 32 HP:0005180
5 bilateral ptosis 32 HP:0001488
6 perimembranous ventricular septal defect 32 HP:0011682
7 intestinal pseudo-obstruction 32 HP:0004389
8 abnormality of the autonomic nervous system 32 HP:0002270
9 hypoperistalsis 32 HP:0100771
10 barrett esophagus 32 HP:0100580

Drugs & Therapeutics for Mungan Syndrome

Drugs for Mungan Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Lactoferrin

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Lactoferrin Prophylaxis in VLBW and Regulator T-cells Completed NCT01287507

Search NIH Clinical Center for Mungan Syndrome

Genetic Tests for Mungan Syndrome

Anatomical Context for Mungan Syndrome

MalaCards organs/tissues related to Mungan Syndrome:

39
T Cells

Publications for Mungan Syndrome

Variations for Mungan Syndrome

Expression for Mungan Syndrome

Search GEO for disease gene expression data for Mungan Syndrome.

Pathways for Mungan Syndrome

GO Terms for Mungan Syndrome

Sources for Mungan Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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