MCID: MRR003
MIFTS: 39

Murray Valley Encephalitis malady

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Murray Valley Encephalitis

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Aliases & Descriptions for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 11 13 68
Australian Encephalitis 11
 
Australian X Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:10842
ICD1030 A83.4
SNOMED-CT62 66454007
ICD9CM32 062.4

Summaries for Murray Valley Encephalitis

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Disease Ontology:11 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary: Murray Valley Encephalitis, also known as australian encephalitis, is related to japanese encephalitis and encephalitis, and has symptoms including fever, headache and nausea. An important gene associated with Murray Valley Encephalitis is RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways are CD209 (DC-SIGN) signaling and G-protein signaling_K-RAS regulation pathway. Affiliated tissues include brain, brain and testes, and related mouse phenotypes are neoplasm and integument.

Related Diseases for Murray Valley Encephalitis

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Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1japanese encephalitis25.4CD40LG, DICER1, DROSHA, ERVW-1, IL2, KRAS
2encephalitis11.1
3pterygium colli mental retardation digital anomalies10.6KRAS, RAF1
4rad51c-related fanconi anemia10.6KRAS, RAF1
5ainhum10.5CD40LG, RAF1
6brachial plexus neuritis10.5KRAS, RAF1
7bladder benign neoplasm10.5KRAS, RAF1
8bone cancer10.4CD40LG, MYOM2
9rete ovarii cystadenoma10.4CD40LG, MYOM2
10calcinosis10.4CD40LG, MYOM2
11classic pulmonary blastoma10.4DICER1, KRAS
12radioulnar synostosis10.4KRAS, RAF1
13ureter leiomyoma10.4CD40LG, MYOM2
14infertility10.3CD40LG, MYOM2
15smoldering myeloma10.3CD40LG, MYOM2
16temporal arteritis10.3CD40LG, MYOM2
17non-secretory myeloma10.3CD40LG, MYOM2
18dentin dysplasia10.3CD40LG, KRAS, RAF1
19secretory diarrhea10.3CD40LG, STAB2
20brucella abortus brucellosis10.3CD40LG, IL2
21phlyctenulosis10.3CD40LG, MYOM2
22generalized atherosclerosis10.3CD40LG, MYOM2
23agammaglobulinemia, microcephaly, and severe dermatitis10.3CD40LG, IL2
24strawberry gallbladder10.3CD40LG, IL2
25maligant granulosa cell tumor of ovary10.2IL2, MYOM2
26solitary osseous plasmacytoma10.2IL2, MYOM2
27west nile virus10.2
28neurofibroma of the esophagus10.1IL2, MYOM2
29huntington disease-like 110.1PRNP, THY1
30pneumonic tularemia10.1CD40LG, IL2
31epididymis adenomatoid tumor10.1CD40LG, MYOM2
32st. louis encephalitis10.1
33early congenital syphilis10.1CD40LG, IL2, KRAS
34foodborne botulism10.1CD40LG, MYOM2
35ovarian endometrioid malignant adenofibroma10.1CD40LG, IL2
36night blindness10.0CD40LG, ERVW-1
37lacrimal system cancer10.0CD40LG, IL2, MYOM2
38renovascular hypertension10.0CD40LG, IL2, MYOM2
39bacteriuria10.0CD40LG, IL2, MYOM2
40heart lymphoma10.0CD40LG, MYOM2
41hemolytic anemia10.0CD40LG, IL2, MYOM2
42organ system benign neoplasm10.0CD40LG, IL2, MYOM2
43male urethral cancer10.0CD40LG, IL2
44louping ill9.9
45poliomyelitis9.9
46herpes simplex9.9
47yellow fever9.9
48herpes simplex encephalitis9.9
49gemistocytic astrocytoma9.9CD40LG, IL2, PRNP
50sweat gland cancer9.9CD40LG, ERVW-1

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to murray valley encephalitis

Symptoms & Phenotypes for Murray Valley Encephalitis

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Symptoms:

 11 (show all 8)
  • fever
  • headache
  • nausea
  • vomiting
  • drowsiness
  • confusion
  • fitting
  • weakness

MGI Mouse Phenotypes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5DICER1, IL2, KRAS, RAF1, STAB2
2MP:00107719.2CD40LG, DICER1, DROSHA, KRAS, PRNP, RAF1
3MP:00053709.2DICER1, DROSHA, IL2, KRAS, RAF1, STAB2
4MP:00053858.9CD40LG, DICER1, DROSHA, IL2, KRAS, RAF1
5MP:00053798.7CD40LG, DICER1, DROSHA, IL2, KRAS, PRNP
6MP:00028738.7DICER1, DROSHA, KRAS, PRNP, RAF1, STAB2
7MP:00053887.9DICER1, DROSHA, IL2, KRAS, RAF1, STAB2

Drugs & Therapeutics for Murray Valley Encephalitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

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Anatomical Context for Murray Valley Encephalitis

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MalaCards organs/tissues related to Murray Valley Encephalitis:

36
Brain, Testes, Neutrophil, B cells, Kidney

FMA organs/tissues related to Murray Valley Encephalitis:

17
Brain

Publications for Murray Valley Encephalitis

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Articles related to Murray Valley Encephalitis:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea. (27086158)
2016
2
A Bayesian Belief Network for Murray Valley encephalitis virus risk assessment in Western Australia. (26823368)
2016
3
Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt? (26601912)
2016
4
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. (26600318)
2015
5
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction. (26377679)
2015
6
Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. (26373772)
2015
7
A case of Murray Valley encephalitis in a 2-year-old Australian Stock Horse in south-east Queensland. (25708787)
2015
8
Visual detection of murray valley encephalitis virus by reverse transcription loop-mediated isothermal amplification. (25800449)
2015
9
The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. (24466360)
2014
10
Complete genome sequences of the prototype isolates of genotypes 2, 3, and 4 of murray valley encephalitis virus. (24948762)
2014
11
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western Australia. (25490948)
2014
12
Low seroprevalence of Murray Valley encephalitis and Kunjin viruses in an opportunistic serosurvey, Victoria 2011. (24090325)
2013
13
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. (24333681)
2013
14
A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cells. (23460804)
2013
15
Clinical and radiological predictors of outcome for Murray Valley encephalitis. (23296449)
2013
16
Molecular characterization and phylogenetic analysis of Murray Valley encephalitis virus and West Nile virus (Kunjin subtype) from an arbovirus disease outbreak in horses in Victoria, Australia, in 2011. (23345269)
2013
17
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study. (23974013)
2013
18
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. (22432670)
2012
19
Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease. (22991186)
2012
20
Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse. (22379060)
2012
21
Opportunistic serological surveillance for Murray Valley encephalitis virus in Victoria, February-May 2011. (22860790)
2012
22
Biochemical characterisation of Murray Valley encephalitis virus proteinase. (20621842)
2010
23
Factsheet: Murray Valley encephalitis. (21604606)
2010
24
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. (19109382)
2009
25
Murray Valley encephalitis virus. (20191691)
2009
26
Influence of hosts on the ecology of arboviral transmission: potential mechanisms influencing dengue, Murray Valley encephalitis, and Ross River virus in Australia. (18800866)
2009
27
Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature. (17161855)
2007
28
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972-2003. (17393295)
2007
29
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. (17622627)
2007
30
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. (17893366)
2007
31
In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein. (17374761)
2007
32
Murray valley encephalitis mimicking herpes simplex encephalitis. (16169227)
2005
33
Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus. (14991436)
2004
34
Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. (12810865)
2003
35
Epizootic activity of Murray Valley encephalitis and Kunjin viruses in an aboriginal community in the southeast Kimberley region of Western Australia: results of mosquito fauna and virus isolation studies. (14628944)
2003
36
MR findings in Murray Valley encephalitis. (12917132)
2003
37
Polymerase chain reaction tests for the identification of Ross River, Kunjin and Murray Valley encephalitis virus infections in horses. (15084017)
2003
38
Clinical and laboratory findings on the first imported case of Murray Valley encephalitis in Europe. (12856229)
2003
39
Murray Valley encephalitis: case report and review of neuroradiological features. (12581057)
2003
40
Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. (11967307)
2002
41
Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. (11950201)
2002
42
Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season. (12653302)
2002
43
Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. (12408675)
2002
44
Murray Valley encephalitis virus recombinant subviral particles protect mice from lethal challenge with virulent wild-type virus. (12111426)
2002
45
Murray Valley encephalitis virus surveillance and control initiatives in Australia. National Arbovirus Advisory Committee of the Communicable Diseases Network Australia. (11432524)
2001
46
Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein. (11462041)
2001
47
Determination of the intramolecular disulfide bond arrangement and biochemical identification of the glycosylation sites of the nonstructural protein NS1 of Murray Valley encephalitis virus. (11514736)
2001
48
Murray Valley encephalitis (Australian encephalitis): FactSheet. (12105611)
2001
49
Murray valley encephalitis. (11596721)
2001
50
Murray Valley encephalitis in Mt Isa, north Queensland. Tropical Public Health Unit Network, Queensland Health. (11432525)
2001

Variations for Murray Valley Encephalitis

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Expression for genes affiliated with Murray Valley Encephalitis

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Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for genes affiliated with Murray Valley Encephalitis

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GO Terms for genes affiliated with Murray Valley Encephalitis

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Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell receptor signaling pathwayGO:005086010.1PRNP, THY1
2pre-miRNA processingGO:00310549.9DICER1, DROSHA
3production of siRNA involved in RNA interferenceGO:00304229.8DICER1, DROSHA
4positive regulation of protein phosphorylationGO:00019349.7IL2, KRAS, RAF1
5negative regulation of apoptotic processGO:00430669.5CD40LG, IL2, PRNP, RAF1

Molecular functions related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoribonuclease activityGO:00045219.9DICER1, DROSHA
2ribonuclease III activityGO:00045259.8DICER1, DROSHA

Sources for Murray Valley Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet