MCID: MRR003
MIFTS: 44

Murray Valley Encephalitis malady

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Murray Valley Encephalitis

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Aliases & Descriptions for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 10 12 65
Australian Encephalitis 10
 
Australian X Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:10842
ICD1027 A83.4
SNOMED-CT59 66454007
ICD9CM29 062.4
UMLS65 C0153066

Summaries for Murray Valley Encephalitis

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Disease Ontology:10 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary: Murray Valley Encephalitis, also known as australian encephalitis, is related to louping ill and encephalitis, and has symptoms including fever, headache and nausea. An important gene associated with Murray Valley Encephalitis is RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways are MAP2K and MAPK activation and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include brain, brain and breast, and related mouse phenotypes are liver/biliary system and respiratory system.

Related Diseases for Murray Valley Encephalitis

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Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1louping ill30.6CD40LG, IL2
2encephalitis11.2
3schizophreniform disorder10.6CD40LG, RAF1
4reproductive organ benign neoplasm10.5KRAS, RAF1
5punctate acrokeratoderma freckle like pigmentation10.5KRAS, RAF1
6japanese encephalitis10.5
7dengue shock syndrome10.5CD40LG, STAB2
8maxillary sinusitis10.5CD40LG, F9
9babesiosis10.5CD40LG, F9
10malignant fibroxanthoma10.4F9, KRAS
11dengue hemorrhagic fever10.4CD40LG, RAF1
12gallbladder leiomyosarcoma10.4F9, KRAS
13brucella melitensis brucellosis10.4CD40LG, IL2
14neonatal anemia10.4IL3, STAB2
15hyperinsulinism10.3CD40LG, IL2
16melas syndrome10.3KRAS, RAF1
17west nile virus10.3
18b cell deficiency10.3CD40LG, IL2
19variola major10.3CD40LG, IL2
20limbic encephalitis with ncmags antibodies10.3IL2, IL3
21tuberculous pneumothorax10.3CD40LG, IL2
22opportunistic bacterial infectious disease10.2CD40LG, IL2
23malignant choroid melanoma10.2CD40LG, IL2
24st. louis encephalitis10.2
25al gazali aziz salem syndrome10.2F9, IL3
26cryoglobulinemia10.2CD40LG, IL2
27strawberry gallbladder10.1ERVW-1, STAB2
28benign breast adenomyoepithelioma10.1F9, IL3
29prion disease with protracted course10.1PRNP, THY1
30poliomyelitis10.1
31herpes simplex10.1
32yellow fever10.1
33herpes simplex encephalitis10.1
34bacterial exanthem10.0CD40LG, IL2, KRAS
35lens subluxation10.0CD40LG, ERVW-1
36cll/sll10.0CD40LG, F9, IL2
37thrombocytopenia due to platelet alloimmunization10.0CD40LG, IL2
38chronic eosinophilic pneumonia10.0CD40LG, IL2, IL3
39diffuse cutaneous mastocytosis10.0IL2, IL3
40cell type benign neoplasm10.0CD40LG, IL2, IL3
41leech infestation9.9CD40LG, IL2
42smoking as a quantitative trait locus 19.9CD40LG, IL2, IL3
43capillariasis9.8CD40LG, F9
44mitochondrial metabolism disease9.8CD40LG, IL2, PRNP
45colon sarcoma9.6CD40LG, ERVW-1, IL2
46urethral diverticulum9.6CD40LG, ERVW-1, IL2
47irf6-related disorders9.5ERVW-1, IL2
48angiodysplasia of intestine9.4ERVW-1, F9, KRAS, RAF1
49neuroaxonal dystrophy9.2CD40LG, ERVW-1, KRAS, RAF1, STAB2
50western equine encephalitis6.7CD40LG, ERVW-1, F9, IL2, IL3, KRAS

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to murray valley encephalitis

Symptoms for Murray Valley Encephalitis

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Symptoms:

 10 (show all 8)
  • fever
  • headache
  • nausea
  • vomiting
  • drowsiness
  • confusion
  • fitting
  • weakness

Drugs & Therapeutics for Murray Valley Encephalitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

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Anatomical Context for Murray Valley Encephalitis

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MalaCards organs/tissues related to Murray Valley Encephalitis:

33
Brain, Breast, Prostate, T cells, B cells, Lung, Heart

FMA organs/tissues related to Murray Valley Encephalitis:

16
Brain

Animal Models for Murray Valley Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Murray Valley Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7F9, IL2, KRAS, RAF1, STAB2
2MP:00053888.4IL2, KRAS, RAF1, STAB2, THY1
3MP:00053858.2CD40LG, F9, IL2, KRAS, RAF1, STAB2

Publications for Murray Valley Encephalitis

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Articles related to Murray Valley Encephalitis:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. (24333681)
2013
2
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. (22432670)
2012
3
Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease. (22991186)
2012
4
Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse. (22379060)
2012
5
Biochemical characterisation of Murray Valley encephalitis virus proteinase. (20621842)
2010
6
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. (19109382)
2009
7
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. (17893366)
2007
8
Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature. (17161855)
2007
9
MR findings in Murray Valley encephalitis. (12917132)
2003
10
Polymerase chain reaction tests for the identification of Ross River, Kunjin and Murray Valley encephalitis virus infections in horses. (15084017)
2003
11
Clinical and laboratory findings on the first imported case of Murray Valley encephalitis in Europe. (12856229)
2003
12
Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. (11967307)
2002
13
Murray Valley encephalitis (Australian encephalitis): FactSheet. (12105611)
2001
14
Murray Valley encephalitis virus surveillance and control initiatives in Australia. National Arbovirus Advisory Committee of the Communicable Diseases Network Australia. (11432524)
2001
15
Murray Valley encephalitis in Western Australia in 2000, with evidence of southerly spread. (11225378)
2000
16
Early diagnosis of Murray Valley encephalitis by reverse transcriptase-polymerase chain reaction. (10740807)
2000
17
The severity of murray valley encephalitis in mice is linked to neutrophil infiltration and inducible nitric oxide synthase activity in the central nervous system. (10482632)
1999
18
DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus. (9770429)
1998
19
Molecular characterization of virus-specific RNA produced in the brains of flavivirus-susceptible and -resistant mice after challenge with Murray Valley encephalitis virus. (9010281)
1997
20
Protective immune responses to the E and NS1 proteins of Murray Valley encephalitis virus in hybrids of flavivirus-resistant mice. (8683218)
1996
21
Two possible mechanisms for survival and initiation of Murray Valley encephalitis virus activity in the Kimberley region of Western Australia. (7625542)
1995
22
Murray valley encephalitis virus envelope protein antigenic variants with altered hemagglutination properties and reduced neuroinvasiveness in mice. (7645203)
1995
23
A synthetic peptide to the E glycoprotein of Murray Valley encephalitis virus defines multiple virus-reactive T- and B-cell epitopes. (1383567)
1992
24
The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein. (1280384)
1992
25
Epitope analysis of the envelope and non-structural glycoproteins of Murray Valley encephalitis virus. (1703213)
1990
26
Synthetic peptides derived from the deduced amino acid sequence of the E-glycoprotein of Murray Valley encephalitis virus elicit antiviral antibody. (2472704)
1989
27
Isolation of Murray Valley encephalitis and Ross River viruses from Aedes normanensis (Diptera: Culicidae) in Western Australia. (2540334)
1989
28
Genetic variation of Murray Valley encephalitis virus. (2841405)
1988
29
A method for predicting Murray Valley encephalitis in southeast Australia using the Southern Oscillation. (3036054)
1986
30
Experimental infection with Murray Valley encephalitis virus: galahs, sulphur-crested cockatoos, corellas, black ducks and wild mice. (3004402)
1985
31
Transovarial transmission of Murray Valley encephalitis virus by Aedes aegypti (L). (6263238)
1980
32
Quantitative studies of the vector competence of Aedes aegypti, Culex annulirostris and other mosquitoes (Diptera: Culicidae) with Murray Valley encephalitis and other Queensland arboviruses. (42801)
1979
33
Serological evidence of inter-epidemic infection of feral pigs in New South Wales with Murray Valley encephalitis virus. (1016127)
1976
34
The proteins of Murray Valley encephalitis virus. (806663)
1975
35
Letter: Murray Valley encephalitis virus in Eastern Australia, 1971. (4758166)
1973
36
Intratypic antigenic variation among strains of the group B arboviruses Murray Valley encephalitis and Kunjin. (4997354)
1971
37
A fatal case of Murray Valley encephalitis. (5430492)
1970
38
Studies of the morphology of Murray Valley encephalitis and Japanese encephalitis viruses growing in cultured mosquito cells. (5651024)
1968
39
A plaque assay method for Murray Valley encephalitis virus. (13965581)
1963
40
Antibody to Murray valley encephalitis and louping-ill viruses in Austrlia and Pauua-New Guinea. (13683282)
1961
41
The action of phospholipase A and lipid solvents on Murray Valley encephalitis virus. (13683281)
1961
42
Murray Valley encephalitis in Papua and New Guinea. II. Serological survey, 1956-1957. (13683283)
1960
43
Studies of arthropod-borne virus infections in Queensland. II. Serological investigations of antibodies to dengue and Murray Valley encephalitis in Eastern Queensland. (13723470)
1960
44
Some aspects of the reaction between crude Murray Valley encephalitis (MVE) virus and deoxycholate. (13669348)
1959
45
Murray Valley encephalitis and Australian X disease. (13221810)
1954
46
The absence of Murray Valley encephalitis virus from the Murray Valley, 1952-1953. (13132162)
1954
47
Murray Valley encephalitis; clinical aspects. (14909903)
1952
48
Murray Valley encephalitis; pathological aspects. (14909904)
1952
49
Murray Valley encephalitis infection in the laboratory mouse. II. Multiplication of virus inoculated intramuscularly. (12997454)
1952
50
Murray Valley encephalitis. (14913606)
1951

Variations for Murray Valley Encephalitis

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Expression for genes affiliated with Murray Valley Encephalitis

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Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for genes affiliated with Murray Valley Encephalitis

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Pathways related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.8KRAS, RAF1
29.8KRAS, RAF1
39.8KRAS, RAF1
49.8KRAS, RAF1
59.8KRAS, RAF1
69.6CD40LG, IL2
79.3IL3, KRAS, RAF1
8
Show member pathways
9.3IL3, KRAS, RAF1
99.3IL3, KRAS, RAF1
10
Show member pathways
9.2IL2, IL3, RAF1
11
Show member pathways
9.2IL2, IL3, RAF1
12
Show member pathways
9.2CD40LG, IL2, IL3
139.0IL2, IL3, THY1
14
Show member pathways
8.9CD40LG, IL2, KRAS, RAF1
15
Show member pathways
8.8IL2, IL3, KRAS, RAF1
168.8IL2, IL3, KRAS, RAF1
17
Show member pathways
8.4F9, IL2, IL3, KRAS, RAF1

GO Terms for genes affiliated with Murray Valley Encephalitis

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Cellular components related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3CD40LG, STAB2, THY1

Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1IL2, IL3
2activation of MAPKK activityGO:00001869.6IL2, KRAS, RAF1
3MAPK cascadeGO:00001659.5IL2, IL3, KRAS
4epidermal growth factor receptor signaling pathwayGO:00071739.3IL2, IL3, KRAS, RAF1
5fibroblast growth factor receptor signaling pathwayGO:00085439.3IL2, IL3, KRAS, RAF1
6vascular endothelial growth factor receptor signaling pathwayGO:00480109.1IL2, IL3, KRAS, RAF1
7insulin receptor signaling pathwayGO:00082869.1IL2, IL3, KRAS, RAF1
8innate immune responseGO:00450878.8IL2, IL3, KRAS, RAF1
9negative regulation of apoptotic processGO:00430668.8CD40LG, IL2, PRNP, RAF1
10axon guidanceGO:00074118.6IL2, KRAS, PRNP, RAF1
11neurotrophin TRK receptor signaling pathwayGO:00480118.5IL2, IL3, KRAS, RAF1

Sources for Murray Valley Encephalitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet