MCID: MRR003
MIFTS: 37

Murray Valley Encephalitis malady

Infectious diseases category

Summaries for Murray Valley Encephalitis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in murray valley encephalitis virus, which is transmitted by culex annulirostris mosquitoes. the infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards: Murray Valley Encephalitis, also known as australian encephalitis, is related to encephalitis and yellow fever, and has symptoms including fitting, drowsiness and confusion. An important gene associated with Murray Valley Encephalitis is RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1), and among its related pathways are NCAM signaling for neurite out-growth and SHC1 events in ERBB2 signaling. The compound pd-184352 have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Aliases & Classifications for Murray Valley Encephalitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

murray valley encephalitis 8 10 60
australian encephalitis 8
australian x disease 8


External Ids:

Disease Ontology8 DOID:10842
ICD9CM27 062.4
SNOMED-CT56 66454007
ICD1025 A83.4

Related Diseases for Murray Valley Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.1RAF1
2yellow fever30.4KRAS, RAF1
3kunjin encephalitis10.8
4japanese encephalitis10.8
5west nile encephalitis10.7
6st. louis encephalitis10.5
7viral encephalitis10.5
8louping ill10.3
9herpes simplex10.3
10poliomyelitis10.3
11cardiofaciocutaneous syndrome10.0KRAS
12tick-borne encephalitis10.0RAF1
13juvenile myelomonocytic leukemia10.0KRAS
14dengue disease10.0RAF1, KRAS
15factor vii deficiency10.0KRAS, RAF1
16neurofibromatosis10.0RAF1, KRAS
17noonan syndrome10.0KRAS, RAF1

Graphical network of diseases related to Murray Valley Encephalitis:



Diseases related to murray valley encephalitis

Clinical Features for Murray Valley Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 8)
  • fitting
  • drowsiness
  • confusion
  • weakness
  • vomiting
  • nausea
  • headache
  • fever

Drugs & Therapeutics for Murray Valley Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Murray Valley Encephalitis

Drug clinical trials:

Search ClinicalTrials for Murray Valley Encephalitis

Search NIH Clinical Center for Murray Valley Encephalitis

Search CenterWatch for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

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Anatomical Context for Murray Valley Encephalitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Murray Valley Encephalitis:

32
Brain, Testes, B cells, Kidney

FMA organs/tissues related to Murray Valley Encephalitis:

14
Brain

Animal Models for Murray Valley Encephalitis or affiliated genes

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Publications for Murray Valley Encephalitis

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50PubMed
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Articles related to Murray Valley Encephalitis:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Clinical and radiological predictors of outcome for Murray Valley encephalitis. (23296449)
2013
2
Molecular characterization and phylogenetic analysis of Murray Valley encephalitis virus and West Nile virus (Kunjin subtype) from an arbovirus disease outbreak in horses in Victoria, Australia, in 2011. (23345269)
2013
3
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. (22432670)
2012
4
Murray Valley encephalitis virus. (20191691)
2009
5
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. (17893366)
2007
6
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972-2003. (17393295)
2007
7
Murray valley encephalitis mimicking herpes simplex encephalitis. (16169227)
2005
8
Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. (11950201)
2002
9
Murray Valley encephalitis (Australian encephalitis): FactSheet. (12105611)
2001
10
Determination of the intramolecular disulfide bond arrangement and biochemical identification of the glycosylation sites of the nonstructural protein NS1 of Murray Valley encephalitis virus. (11514736)
2001
11
Morphological features of Murray Valley encephalitis virus infection in the central nervous system of Swiss mice. (10718862)
2000
12
The severity of murray valley encephalitis in mice is linked to neutrophil infiltration and inducible nitric oxide synthase activity in the central nervous system. (10482632)
1999
13
Characterization of infectious Murray Valley encephalitis virus derived from a stably cloned genome-length cDNA. (10567642)
1999
14
DNA-based and alphavirus-vectored immunisation with prM and E proteins elicits long-lived and protective immunity against the flavivirus, Murray Valley encephalitis virus. (9770429)
1998
15
Characterization of defective viral RNA produced during persistent infection of Vero cells with Murray Valley encephalitis virus. (9499109)
1998
16
Molecular characterization of virus-specific RNA produced in the brains of flavivirus-susceptible and -resistant mice after challenge with Murray Valley encephalitis virus. (9010281)
1997
17
A comparison of the spread of Murray Valley encephalitis viruses of high or low neuroinvasiveness in the tissues of Swiss mice after peripheral inoculation. (8661392)
1996
18
Neurovirulence and neuroinvasiveness of Murray Valley encephalitis virus mutants selected by passage in a monkey kidney cell line. (9049332)
1995
19
Australian X disease, Murray Valley encephalitis and the French connection. (8545982)
1995
20
The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein. (1280384)
1992
21
Proteolytic processing of a Murray Valley encephalitis virus non-structural polyprotein segment containing the viral proteinase: accumulation of a NS3-4A precursor which requires mature NS3 for efficient processing. (1328486)
1992
22
Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence. (2161151)
1990
23
Defined epitope blocking with Murray Valley encephalitis virus and monoclonal antibodies: laboratory and field studies. (1700805)
1990
24
Genetic variation of Murray Valley encephalitis virus. (2841405)
1988
25
Antigenic structure of the Murray Valley encephalitis virus E glycoprotein. (2453607)
1988
26
Genetic differentiation of Murray Valley encephalitis virus in Australia and Papua New Guinea. (2884985)
1986
27
Role of antibodies and host cells in plaque enhancement of Murray Valley encephalitis virus. (6842678)
1983
28
Vector competence of Culex pipiens quinquefasciatus for Murray Valley encephalitis, Kunjin, and Ross River viruses from Australia. (6285750)
1982
29
Serological evidence of inter-epidemic infection of feral pigs in New South Wales with Murray Valley encephalitis virus. (1016127)
1976
30
Murray Valley encephalitis in Australia, 1974: antibody response in cases and community. (1071876)
1976
31
Murray Valley encephalitis, 1974: clinical features. (994930)
1976
32
Letter: Murray Valley encephalitis virus in Eastern Australia, 1971. (4758166)
1973
33
Murray Valley encephalitis in Eastern Australia, 1971. (4642431)
1972
34
Studies of the morphology of Murray Valley encephalitis and Japanese encephalitis viruses growing in cultured mosquito cells. (5651024)
1968
35
The action of phospholipase A and lipid solvents on Murray Valley encephalitis virus. (13683281)
1961
36
Murray Valley encephalitis antibodies in an aboriginal mission in South Australia; the application of the haemagglutination-inhibition test. (13535503)
1958
37
The psychological sequelae to Murray Valley encephalitis. (13492797)
1957
38
Vectors of Murray Valley encephalitis. (13439205)
1957
39
Further observations relating to Murray Valley encephalitis in the northern territory of Australia. (13308573)
1956
40
The absence of Murray Valley encephalitis virus from the Murray Valley, 1952-1953. (13132162)
1954
41
Between Australian x-disease and the virus of Murray Valley encephalitis. (13164666)
1954
42
Infection of birds with Murray Valley encephalitis (X disease). (13159764)
1954
43
Transmission of Murray Valley encephalitis virus by mosquitoes. (13115309)
1953
44
Murray Valley encephalitis; the contrasting epidemiological picture in 1951 and 1952. (13054045)
1953
45
Murray Valley encephalitis: a survey of avian sera, 1951-1952. (13062866)
1953
46
The behaviour of Murray Valley encephalitis virus in young chickens. (13115310)
1953
47
Murray Valley encephalitis; clinical aspects. (14909903)
1952
48
Murray Valley encephalitis isolation and characterization of the aetiological agent. (14909902)
1952
49
Haemagglutination with the virus of Murray Valley encephalitis. (13009040)
1952
50
Murray Valley encephalitis. (14913606)
1951

Genetic Variations for Murray Valley Encephalitis

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Expression for genes affiliated with Murray Valley Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Murray Valley Encephalitis

Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for genes affiliated with Murray Valley Encephalitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Murray Valley Encephalitis

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44Novoseek
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Compounds related to Murray Valley Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pd-184352449.8KRAS, RAF1

GO Terms for genes affiliated with Murray Valley Encephalitis

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16Gene Ontology
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Biological processes related to Murray Valley Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Ras protein signal transductionGO:0072659.8KRAS, RAF1
2activation of MAPKK activityGO:0001869.7KRAS, RAF1
3MAPK cascadeGO:0001659.5KRAS, RAF1

Products for genes affiliated with Murray Valley Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Murray Valley Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet