Aliases & Classifications for Muscle Cancer

Aliases & Descriptions for Muscle Cancer:

Name: Muscle Cancer 12 52 14
Myosarcoma 12 52 42 69
Malignant Neoplasm of Muscle, Nos 12
Malignant Tumor of the Muscle 12
Malignant Neoplasm of Muscle 69
Malignant Tumor of Muscle 12
Myomatous Neoplasm 69
Muscle Neoplasms 42

Classifications:



External Ids:

Disease Ontology 12 DOID:4045
ICD10 33 C49
NCIt 47 C4883

Summaries for Muscle Cancer

Disease Ontology : 12 A musculoskeletal system cancer that is located in muscle.

MalaCards based summary : Muscle Cancer, also known as myosarcoma, is related to skeletal muscle cancer and striated muscle rhabdoid tumor, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Muscle Cancer is PAX3 (Paired Box 3), and among its related pathways/superpathways are Glioma and C-MYB transcription factor network. The drugs Ethanol and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and muscle, and related phenotypes are cellular and growth/size/body region

Wikipedia : 71 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Related Diseases for Muscle Cancer

Diseases related to Muscle Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
id Related Disease Score Top Affiliating Genes
1 skeletal muscle cancer 11.9
2 striated muscle rhabdoid tumor 10.5
3 leiomyosarcoma 10.5
4 rhabdomyosarcoma 10.5
5 myoblastoma 10.3 MYOD1 PAX3 PAX7
6 subacute leukemia 10.3 MB MYOG
7 botryoid rhabdomyosarcoma 10.3 KIT MYOD1
8 brain stem infarction 10.3 MB MYOD1 MYOG
9 appendix leiomyoma 10.3 MB PGR
10 intrahepatic bile duct cystadenoma 10.3 DES MB MYOD1
11 transitional cell carcinoma 10.3 DES MB MYOD1
12 ovarian cystadenoma 10.3 DES MB MYOD1
13 aortitis 10.3 PGR TP53
14 lung benign neoplasm 10.3 DES IGF2 MYOD1
15 amelogenesis imperfecta-gingival hyperplasia syndrome 10.2 MDM2 MYOD1 MYOG
16 carbon monoxide-induced parkinsonism 10.2 DES KIT
17 bone deterioration disease 10.2 DES MB TP53
18 glaucoma iridogoniodysgenesia 10.2 DES MB
19 collecting duct carcinoma 10.2 ASPSCR1 FOXO1 PAX3 TFE3
20 uterine hypoplasia 10.2 IGF2 KIT PGR
21 mixed type rhabdomyosarcoma 10.2 DES MB MYOD1 MYOG
22 marfanoid hypermobility syndrome 10.2 DES KIT PGR
23 rommen mueller sybert syndrome 10.2 MDM2 TP53
24 liver angiosarcoma 10.2 DES KIT PGR
25 ovarian benign neoplasm 10.2 CALD1 PGR
26 sebaceous adenoma 10.2 DES KIT PGR
27 anal buschke-lowenstein tumor 10.2 CD34 PGR
28 plexiform neurofibroma 10.2 CALD1 PGR
29 heart sarcoma 10.2 CALD1 MYOG
30 heart leiomyosarcoma 10.2 CALD1 DES MYOG
31 neurofibroma of gallbladder 10.2 CD34 KIT
32 gallbladder leiomyosarcoma 10.2 CD34 KIT
33 pericardium leiomyoma 10.2 PGR TP53
34 pilar sheath acanthoma 10.2 DES KIT PGR
35 juvenile xanthogranuloma 10.2 DES EWSR1 MYOD1
36 fitz-hugh-curtis syndrome 10.2 DES KIT PGR
37 lymphomatous thyroiditis 10.2 DES PGR
38 ovarian embryonal carcinoma 10.2 KIT PGR TP53
39 postpartum depression 10.2 KIT PGR TP53
40 intraorbital meningioma 10.2 MB MDM2 TP53
41 verruciform xanthoma of skin 10.2 DES MB MYOD1 TP53
42 gangliosidosis gm1 10.2 DES KIT PGR
43 reactive arthritis 10.2 KIT PGR TP53
44 kidney sarcoma 10.2 EWSR1 KIDINS220 MYOD1 MYOG
45 bile duct rhabdomyosarcoma 10.2 DES MB MYOD1 PAX3 PAX7
46 coronary restenosis 10.2 EWSR1 IGF2 KIT
47 speech disorder 10.2 CD34 KIT
48 coronary stenosis 10.2 DES MDM2 TP53
49 house allergic alveolitis 10.2 DES MDM2 TP53
50 diabetes persistent mullerian ducts 10.2 DES EWSR1 MYOD1 MYOG

Graphical network of the top 20 diseases related to Muscle Cancer:



Diseases related to Muscle Cancer

Symptoms & Phenotypes for Muscle Cancer

UMLS symptoms related to Muscle Cancer:


muscle cramp, muscle rigidity, muscle spasticity, myoclonus, torticollis, muscle weakness, myalgia

MGI Mouse Phenotypes related to Muscle Cancer:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.35 CD34 DES FOXO1 IGF2 KIDINS220 KIT
2 growth/size/body region MP:0005378 10.34 CREB3L2 FOXO1 IGF2 KIDINS220 KIT MB
3 cardiovascular system MP:0005385 10.32 DES FOXO1 IGF2 KIDINS220 KIT MB
4 homeostasis/metabolism MP:0005376 10.31 CD34 DES FOXO1 IGF2 KIT MB
5 mortality/aging MP:0010768 10.31 IGF2 KIDINS220 KIT MB MDM2 MYOD1
6 hematopoietic system MP:0005397 10.29 CD34 FOXO1 IGF2 KIT MB MDM2
7 embryo MP:0005380 10.24 FOXO1 IGF2 KIT MB MDM2 MYOG
8 craniofacial MP:0005382 10.21 CREB3L2 FOXO1 IGF2 KIT MDM2 PAX3
9 integument MP:0010771 10.18 PGR TFE3 TP53 CD34 FOXO1 IGF2
10 muscle MP:0005369 10.18 DES FOXO1 IGF2 KIT MB MDM2
11 digestive/alimentary MP:0005381 10.15 CREB3L2 FOXO1 IGF2 KIT MDM2 PAX3
12 limbs/digits/tail MP:0005371 10.06 CREB3L2 FOXO1 IGF2 KIT MDM2 PAX3
13 no phenotypic analysis MP:0003012 10.06 FOXO1 IGF2 KIDINS220 KIT MDM2 MYOD1
14 neoplasm MP:0002006 10.02 CD34 FOXO1 KIT MDM2 MYOD1 PAX3
15 normal MP:0002873 9.96 FOXO1 KIT MDM2 MYOD1 MYOG PAX3
16 respiratory system MP:0005388 9.56 IGF2 KIT MB MYOD1 MYOG PAX3
17 pigmentation MP:0001186 9.55 KIT MDM2 PAX3 TFE3 TP53
18 skeleton MP:0005390 9.4 MYOD1 MYOG PAX3 PAX7 PGR TFE3

Drugs & Therapeutics for Muscle Cancer

Drugs for Muscle Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 744)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 1 64-17-5 702
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Zinc Approved Phase 4,Early Phase 1 7440-66-6 32051 23994
4
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
5
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Midazolam Approved, Illicit Phase 4,Early Phase 1 59467-70-8 4192
8
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
9
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
10
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
11
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
12
Goserelin Approved Phase 4,Phase 3,Phase 1 65807-02-5 47725 5311128
13
Pentostatin Approved, Investigational Phase 4 53910-25-1 40926 439693
14
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 185243-69-0
15
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
16
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 1 58-61-7 60961
17
Calcium carbonate Approved Phase 4,Phase 3,Phase 2,Early Phase 1 471-34-1
18
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3 137-58-6 3676
19
Desogestrel Approved Phase 4 54024-22-5 40973
20
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
21
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
22
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 1 112809-51-5 3902
23
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
24
Anastrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120511-73-1 2187
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
27
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
28
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2,Phase 3 148553-50-8 5486971
29
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 5460373 44475014
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
31 Dienogest Approved Phase 4 65928-58-7
32
Levobupivacaine Approved Phase 4,Phase 2 27262-47-1 92253
33
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
34
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
35
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
36
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57-83-0 5994
37
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-22-0 6013
38
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
39
Celecoxib Approved, Investigational Phase 4,Phase 2,Phase 1 169590-42-5 2662
40
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
41
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
42
Neostigmine Approved, Vet_approved Phase 4,Phase 3 59-99-4 4456
43
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
44
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
45
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
46
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
47
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
48
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
49
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53714-56-0 3911 657181
50
Remifentanil Approved Phase 4 132875-61-7 60815

Interventional clinical trials:

(show top 50) (show all 1614)
id Name Status NCT ID Phase
1 Serratus Anterior Plane Block Versus Paravertebral Block for Postmastectomy Analgesia Unknown status NCT02103946 Phase 4
2 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4
3 Study of the Effect of Glutamine Supplementation on Chemotherapy Induced Toxicities in Breast Cancer Patients Unknown status NCT00772824 Phase 4
4 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4
5 Influence of Profound Muscle Relaxation on Muscle Trauma and Postoperative Pulmonary Function Unknown status NCT01804933 Phase 4
6 Quadratus Lumborum Block for Percutaneous Nephrostomy Unknown status NCT02121951 Phase 4
7 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
8 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4
9 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4
10 The Hysteroscopic Morcellator (HM). Unknown status NCT01537822 Phase 4
11 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
12 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4
13 MyoSure Hysteroscopic Tissue Removal System Registry Study Unknown status NCT01369758 Phase 4
14 Effect of Pioglitazone on TIMP-3 and TACE in Type 2 Diabetes Completed NCT01223196 Phase 4
15 Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors Completed NCT00168987 Phase 4
16 Study to Monitor the Effects of Androgen Suppression Treatment on the Heart Completed NCT01230905 Phase 4
17 The Laparotomy Study Completed NCT02140593 Phase 4
18 Prevention of Osteoporosis in Breast Cancer Survivors Completed NCT00567606 Phase 4
19 Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration Completed NCT01161563 Phase 4
20 Comparison of Laryngeal Mask Airway (LMA®) and Tracheal Tube in Modified Radical Mastectomy on Breast Cancer Completed NCT00638599 Phase 4
21 The Effect of Darbepoetin Upon Rehabilitation for Colorectal Cancer Surgery Completed NCT00122720 Phase 4
22 Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy Completed NCT02320734 Phase 4
23 Myobloc Atrophy Study Completed NCT02052024 Phase 4
24 The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway Completed NCT00755729 Phase 4
25 The Role of Vitamin D in Immune Function in Patients With Chronic Kidney Disease (CKD) Stages 3 and 4. Completed NCT00749736 Phase 4
26 Long-Term Lamivudine Therapy for Chronic Hepatitis B Completed NCT00120354 Phase 4
27 Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block Completed NCT01199237 Phase 4
28 Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women Completed NCT00145392 Phase 4
29 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
30 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4
31 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4
32 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4
33 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4
34 Pioglitazone Treatment in Polycystic Ovary Syndrome Completed NCT00145340 Phase 4
35 Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance Completed NCT00667498 Phase 4
36 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4
37 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4
38 Safety Study of ExAblate for the Treatment of Uterine Fibroids Completed NCT01142791 Phase 4
39 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4
40 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
41 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Completed NCT00180739 Phase 4
42 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270 Phase 4
43 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
44 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4
45 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
46 Safety Study of Bipolar Versus Monopolar Transurethral Resection of Bladder Tumors Recruiting NCT01446822 Phase 4
47 Laser En Bloc Resection Of Bladder Tumor (HoLERBT) VS. Conventional Transurethral Resection Of Bladder Tumors (cTURBT) Recruiting NCT02555163 Phase 4
48 Ultrasound-Guided ONB for Transurethral Procedures - Interadductor Approach Recruiting NCT02696733 Phase 4
49 Analgesic Effects of Ultrasound Guided PEC Blocks on Analgesic Opioid Consumption of Cancer Surgery Patients Recruiting NCT02495363 Phase 4
50 Transitional Growth Hormone (GH) Use in Growth Hormone Deficient (GHD) Cancer Survivors Recruiting NCT02629926 Phase 4

Search NIH Clinical Center for Muscle Cancer

Cochrane evidence based reviews: myosarcoma

Genetic Tests for Muscle Cancer

Anatomical Context for Muscle Cancer

MalaCards organs/tissues related to Muscle Cancer:

39
Skeletal Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Muscle Cancer:

18
Muscle

Publications for Muscle Cancer

Articles related to Muscle Cancer:

id Title Authors Year
1
YAPping about differentiation therapy in muscle cancer. ( 25117705 )
2014
2
The not-so-skinny on muscle cancer. ( 23079652 )
2012
3
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. ( 20193046 )
2010
4
A new model for muscle cancer. ( 17585343 )
2007

Variations for Muscle Cancer

Expression for Muscle Cancer

Search GEO for disease gene expression data for Muscle Cancer.

Pathways for Muscle Cancer

GO Terms for Muscle Cancer

Cellular components related to Muscle Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.32 ASPSCR1 CREB3L2 FOXO1 MDM2 MYOD1 MYOG

Biological processes related to Muscle Cancer according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.61 MYOD1 MYOG PAX7
2 myotube differentiation GO:0014902 9.51 MYOD1 MYOG
3 positive regulation of transcription, DNA-templated GO:0045893 9.5 CREB3L2 FOXO1 MYOD1 MYOG PAX3 TFE3
4 positive regulation of skeletal muscle fiber development GO:0048743 9.48 MYOD1 MYOG
5 muscle cell fate commitment GO:0042693 9.46 MYOD1 MYOG
6 muscle organ development GO:0007517 9.46 MYOD1 MYOG PAX3 PAX7
7 paracrine signaling GO:0038001 9.37 CD34 PGR
8 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
9 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.28 CREB3L2 FOXO1 MYOD1 MYOG PAX3 PAX7
10 transcription, DNA-templated GO:0006351 10.1 CREB3L2 EWSR1 FOXO1 MYOD1 MYOG PAX3
11 multicellular organism development GO:0007275 10.04 CREB3L2 IGF2 MYOD1 MYOG PAX3 PAX7
12 regulation of transcription, DNA-templated GO:0006355 10 CREB3L2 EWSR1 FOXO1 IGF2 MYOD1 MYOG

Molecular functions related to Muscle Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.56 CREB3L2 MYOG PGR TFE3
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.55 CREB3L2 MYOD1 MYOG PGR TFE3
3 sequence-specific DNA binding GO:0043565 9.5 CREB3L2 FOXO1 MYOD1 MYOG PAX3 PAX7
4 transcription factor activity, sequence-specific DNA binding GO:0003700 9.28 CREB3L2 FOXO1 MYOD1 MYOG PAX3 PAX7

Sources for Muscle Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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