MCID: MSC004
MIFTS: 39

Muscle Tissue Disease

Categories: Muscle diseases

Aliases & Classifications for Muscle Tissue Disease

MalaCards integrated aliases for Muscle Tissue Disease:

Name: Muscle Tissue Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:66

Summaries for Muscle Tissue Disease

MalaCards based summary : Muscle Tissue Disease is related to localized lipodystrophy and cytoplasmic body myopathy. An important gene associated with Muscle Tissue Disease is DMD (Dystrophin), and among its related pathways/superpathways are BMP Pathway and Dilated cardiomyopathy (DCM). The drugs Ethanol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Muscle Tissue Disease

Diseases related to Muscle Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 localized lipodystrophy 10.7 DMD DYSF
2 cytoplasmic body myopathy 10.7 DMD UTRN
3 polyglucosan body myopathy 1 with or without immunodeficiency 10.7 CAPN3 DMD
4 survival motor neuron spinal muscular atrophy 10.7 SMN1 SMN2
5 juvenile spinal muscular atrophy 10.7 SMN1 SMN2
6 anterior compartment syndrome 10.7 ANO5 DYSF
7 oculopharyngodistal myopathy 10.7 GNE PABPN1
8 cardiomyopathy, dilated, 3b 10.7 DMD SGCA
9 charcot-marie-tooth disease, dominant intermediate b 10.7 MTM1 RYR1
10 cardiomyopathy, dilated, 1d 10.6 DAG1 DMD LAMA2
11 spinal muscular atrophy, type ii 10.6 SMN1 SMN2
12 fukuyama type muscular dystrophy 10.6 FKRP FKTN
13 spinal muscular atrophy, type iv 10.6 MSTN SMN1 SMN2
14 congenital muscular dystrophy without intellectual disability 10.6 FKRP FKTN
15 spinal muscular atrophy, type iii 10.6 SMN1 SMN2
16 myopathy, congenital 10.6 DMD MTM1 RYR1
17 bethlem myopathy 1 10.6 CAPN3 DMD DYSF
18 rippling muscle disease 2 10.6
19 distal arthrogryposis 10.6
20 myostatin-related muscle hypertrophy 10.6
21 myotonia congenita 10.6
22 centronuclear myopathy 10.6 DMD MTM1 RYR1
23 miyoshi muscular dystrophy 1 10.6 CAPN3 DYSF
24 autosomal recessive limb-girdle muscular dystrophy type 2f 10.6 CAPN3 DYSF SGCA
25 muscular dystrophy-dystroglycanopathy , type a, 1 10.6 FKRP FKTN
26 isolated hyperckemia 10.6 CAPN3 DMD FKRP
27 spinal disease 10.6 SMN1 SMN2
28 brody myopathy 10.6 DMD RYR1
29 autosomal dominant limb-girdle muscular dystrophy type 1c 10.6 DYSF FKRP
30 myopathy, proximal, and ophthalmoplegia 10.6 EMD RYR1
31 autosomal recessive limb-girdle muscular dystrophy type 2h 10.6 CAPN3 DYSF FKRP
32 muscular dystrophy, limb-girdle, type 2h 10.6 CAPN3 DYSF FKRP
33 muscular dystrophy, limb-girdle, type 2j 10.6 CAPN3 FKRP
34 muscular dystrophy, limb-girdle, type 2g 10.6 CAPN3 DYSF FKRP
35 muscular dystrophy, limb-girdle, type 1c 10.6 DYSF FKRP MSTN
36 muscular dystrophy-dystroglycanopathy , type c, 4 10.6 FKRP FKTN
37 dysferlinopathy 10.5 CAPN3 DYSF
38 myotonia 10.5 CLCN1 DMD MSTN
39 cardiomyopathy, dilated, 1b 10.5 DAG1 DMD FKTN LAMA2
40 rigid spine muscular dystrophy 1 10.5 ANO5 DMD DYSF LAMA2
41 cardiomyopathy, dilated, 1a 10.5 DAG1 DMD EMD LAMA2
42 congenital fiber-type disproportion 10.5 DMD DYSF EMD RYR1
43 autosomal recessive limb-girdle muscular dystrophy type 2b 10.5 ANO5 CAPN3 DYSF SGCA
44 central core myopathy 10.5 MTM1 RYR1
45 myopathy, x-linked, with excessive autophagy 10.5 DMD EMD GNE LAMA2
46 muscular dystrophy-dystroglycanopathy , type c, 5 10.5 CAPN3 DYSF FKRP LAMA2
47 lissencephaly 10.5 DAG1 FKRP FKTN
48 familial periodic paralysis 10.5 CLCN1 RYR1
49 progressive muscular atrophy 10.5 SMN1 SMN2
50 mcleod syndrome 10.5 DMD SGCA

Graphical network of the top 20 diseases related to Muscle Tissue Disease:



Diseases related to Muscle Tissue Disease

Symptoms & Phenotypes for Muscle Tissue Disease

MGI Mouse Phenotypes related to Muscle Tissue Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.28 LAMA2 DYSF EMD CLCN1 FKRP DAG1
2 homeostasis/metabolism MP:0005376 10.22 DYSF CAPN3 EMD CLCN1 FKRP DAG1
3 cardiovascular system MP:0005385 10.18 CAPN3 EMD FKRP DAG1 DMD GNE
4 growth/size/body region MP:0005378 10.18 CAPN3 CLCN1 FKRP DAG1 FKTN DMD
5 muscle MP:0005369 10.09 DYSF CAPN3 EMD CLCN1 FBXO32 FKRP
6 mortality/aging MP:0010768 10.03 CLCN1 FKRP DAG1 FKTN GNE DMD
7 no phenotypic analysis MP:0003012 9.5 DYSF CAPN3 CLCN1 DMD SMN2 MSTN
8 skeleton MP:0005390 9.28 CLCN1 FKRP DMD LAMA2 SMN2 MSTN

Drugs & Therapeutics for Muscle Tissue Disease

Drugs for Muscle Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 752)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 1,Early Phase 1 64-17-5 702
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 51-61-6, 62-31-7 681
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
6
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
7
Bezafibrate Approved, Investigational Phase 4,Phase 3,Phase 2 41859-67-0 39042
8
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
9
Colchicine Approved Phase 4 64-86-8 2833 6167
10
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Early Phase 1 103-90-2 1983
11
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
12
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 9004-61-9 53477741 24759
13
Ramipril Approved Phase 4 87333-19-5 5362129
14
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
15
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
16
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
17
Azathioprine Approved Phase 4 446-86-6 2265
18
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
19
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
20
Dronabinol Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 1972-08-3 16078 2978
21
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
22
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
23
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
24
Citalopram Approved Phase 4 59729-33-8 2771
25
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
26
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
27
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1 202409-33-4 123619
28
Abatacept Approved Phase 4,Phase 3,Phase 2,Early Phase 1 332348-12-6 10237
29
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
30
Cortisone acetate Approved, Investigational Phase 4 1950-04-4, 50-04-4 5745
31
Milnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833
32
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1 58-39-9 4748
33
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
34
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
35
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
36
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
37
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2216-51-5 16666
38
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2,Phase 3,Phase 1 148553-50-8 5486971
39
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
40
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
41
Dinoprostone Approved Phase 4 363-24-6 5280360
42
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2 303-53-7 2895
43
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2 56-12-2 119
44
Polidocanol Approved Phase 4,Phase 2 9002-92-0
45
Sodium oxybate Approved Phase 4,Phase 3,Phase 2 502-85-2 5360545
46
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1 4205-90-7 2803
47
Pravastatin Approved Phase 4,Phase 2 81093-37-0 54687
48
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 58-22-0 6013
49
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
50
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033

Interventional clinical trials:

(show top 50) (show all 2635)

# Name Status NCT ID Phase Drugs
1 Identification of Carnitine-Responsive Cardiomyopathy Unknown status NCT01904396 Phase 4 Carnitine
2 Efficacy of Telbivudine With or Without add-on Tenofovir According to Roadmap Strategy Compare With Entecavir Unknown status NCT01588912 Phase 4 Telbivudine;Tenofovir;Entecavir
3 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
4 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
5 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
6 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
7 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
8 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
9 Ramipril Versus Carvedilol in Duchenne and Becker Patients Unknown status NCT00819845 Phase 4 carvedilol;ramipril
10 The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy Unknown status NCT00606775 Phase 4 Carvedilol
11 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
12 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
13 Upper Extremity Rehabilitation Using Robot and Botulinum Toxin Unknown status NCT02228863 Phase 4
14 Corticosteroid Injection Verses High Energy Extracorporeal Shock Wave Therapy for Lateral Epicondylitis Unknown status NCT02613455 Phase 4 Kenalog (triamcinolone);lidocaine 1% (lidocaine HCl 20mg)
15 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
16 The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults Unknown status NCT02505802 Phase 4 BoNT-A injection
17 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
18 Optimal Dose of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity Unknown status NCT02358005 Phase 4
19 Sodium Oxybate in Patients With Chronic Fatigue Syndrome. Unknown status NCT01584934 Phase 4 Sodium oxybate;Placebo
20 Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis Unknown status NCT00173706 Phase 4 L-Carnitine Injection
21 Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke Unknown status NCT02114736 Phase 4 Botulinum Toxin injection in the rectus femoris muscle
22 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy Unknown status NCT01256021 Phase 4 Botulinum Toxin Type A
23 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
24 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
25 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
26 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
27 The Effect of Fibrate Therapy in Two Patients With Neutral Lipid Storage Disease With Myopathy (NLSDM) Completed NCT01527318 Phase 4 Fibrate treatment
28 Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity Completed NCT00199745 Phase 4 atorvastatin
29 Association Between Systemic Exposure of Atorvastatin and Metabolites and Atorvastatin-induced Myotoxicity Completed NCT00120055 Phase 4 Atorvastatin (Lipitor)
30 Investigations on Differences in Atorvastatin Metabolites Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity Completed NCT00414531 Phase 4 Atorvastatin
31 Using Clonidine to Improve Leg Weakness in People With Heart Failure Completed NCT00858845 Phase 4 Clonidine Patch
32 Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations Completed NCT01865500 Phase 4 Budesonide 4 mg;Budesonide 8 mg;Metil prednisolone
33 Effects of Vitamin D Supplementation in Obesity Completed NCT01037140 Phase 4 Cholecalciferol;placebo
34 Effect of Gemfibrozil on the Safety and Pharmacokinetics of Red Yeast Rice in Healthy Subjects Completed NCT01385020 Phase 4 Gemfibrozil & red yeast rice (LipoCol)
35 Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial Completed NCT01372176 Phase 4
36 Effect of Goserelin (Zoladex®) in Spinal and Bulbar Muscular Atrophy Completed NCT00851461 Phase 4 Goserelin
37 Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava Before and After Fluid Therapy Completed NCT01553422 Phase 4
38 Shockwave Therapy of Chronic Achilles Tendinopathy Completed NCT00958620 Phase 4
39 "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" Completed NCT00792376 Phase 4 etoricoxib;diclofenac
40 The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical Trial Completed NCT00761423 Phase 4
41 Achilles Tendinosis Study; Comparison of Radiofrequency to Surgical MicroDebridement Completed NCT00534781 Phase 4
42 The Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles. Tendinopathy Completed NCT00377910 Phase 4 Aethoxysclerol
43 Colloids in Severe Trauma Completed NCT00890383 Phase 4 tetrastarch (Voluven)
44 Discomfort and Psychosocial Difficulties in Fibromyalgia Completed NCT02078791 Phase 4 Botox infiltration
45 Strengthening Exercises for Fibromyalgia Completed NCT02063750 Phase 4
46 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
47 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
48 Effect of Milnacipran on Pain in Fibromyalgia Completed NCT01288807 Phase 4 Milnacipram
49 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
50 A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo

Search NIH Clinical Center for Muscle Tissue Disease

Genetic Tests for Muscle Tissue Disease

Anatomical Context for Muscle Tissue Disease

MalaCards organs/tissues related to Muscle Tissue Disease:

38
Testes, Brain, Spinal Cord, Heart, Bone, Skeletal Muscle, Kidney

Publications for Muscle Tissue Disease

Variations for Muscle Tissue Disease

Expression for Muscle Tissue Disease

Search GEO for disease gene expression data for Muscle Tissue Disease.

Pathways for Muscle Tissue Disease

GO Terms for Muscle Tissue Disease

Cellular components related to Muscle Tissue Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 filopodium GO:0030175 9.56 DAG1 DMD MTM1 UTRN
2 Z disc GO:0030018 9.55 CAPN3 DMD FBXO32 SMN1 SMN2
3 I band GO:0031674 9.54 MTM1 RYR1
4 costamere GO:0043034 9.52 DAG1 DMD
5 SMN-Sm protein complex GO:0034719 9.51 SMN1 SMN2
6 T-tubule GO:0030315 9.5 CAPN3 DYSF RYR1
7 filopodium membrane GO:0031527 9.49 DMD UTRN
8 SMN complex GO:0032797 9.46 SMN1 SMN2
9 Gemini of coiled bodies GO:0097504 9.43 SMN1 SMN2
10 contractile ring GO:0070938 9.4 DAG1 UTRN
11 dystroglycan complex GO:0016011 9.37 DAG1 SGCA
12 dystrophin-associated glycoprotein complex GO:0016010 9.35 DAG1 DMD FKRP SGCA UTRN
13 sarcolemma GO:0042383 9.23 CLCN1 DAG1 DMD DYSF FKRP LAMA2
14 cytoplasm GO:0005737 10.32 CAPN3 DAG1 DMD EMD FBXO32 GNE

Biological processes related to Muscle Tissue Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.7 CLCN1 DYSF EMD PABPN1 RYR1 SGCA
2 skeletal muscle tissue regeneration GO:0043403 9.62 DAG1 DMD MSTN SGCA
3 muscle cell cellular homeostasis GO:0046716 9.56 CAPN3 DMD MSTN MTM1
4 negative regulation of protein kinase B signaling GO:0051898 9.54 DAG1 MSTN MTM1
5 positive regulation of cell-matrix adhesion GO:0001954 9.51 DAG1 UTRN
6 nuclear import GO:0051170 9.49 SMN1 SMN2
7 response to muscle activity GO:0014850 9.48 CAPN3 MSTN
8 protein O-linked mannosylation GO:0035269 9.46 FKRP FKTN
9 DNA-templated transcription, termination GO:0006353 9.43 SMN1 SMN2
10 Schwann cell differentiation GO:0014037 9.4 DAG1 LAMA2
11 response to denervation involved in regulation of muscle adaptation GO:0014894 9.35 DAG1 DMD FBXO32 SGCA UTRN
12 muscle organ development GO:0007517 9.23 CAPN3 DMD EMD FKTN LAMA2 MSTN

Molecular functions related to Muscle Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.56 DAG1 DMD EMD UTRN
2 dystroglycan binding GO:0002162 9.16 DAG1 DMD
3 structural constituent of muscle GO:0008307 9.13 CAPN3 DAG1 DMD
4 vinculin binding GO:0017166 8.8 DAG1 DMD UTRN

Sources for Muscle Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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