Muscular Atrophy malady

Wikipedia: Muscle atrophy, or disuse atrophy, is defined as a decrease in the mass of the muscle; it can be a...⁴⁴ more...

MalaCards: Muscular Atrophy, also known as amyotrophia nos (disorder), is related to spinal muscular atrophy and spinal-bulbar muscular atrophy. An important gene associated with Muscular Atrophy is SMN1 (survival of motor neuron 1, telomeric), and among its related pathways are mRNA Decay by 5 to 3 Exoribonuclease and RNA degradation. The compounds sp 600125 and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and skeletal muscle, and related mouse phenotypes are respiratory system and skeleton.

Aliases & Descriptions:

muscular atrophy 6 8 43 amyotrophia nos (disorder) 6 muscle atrophy (disorder) 6

wasting - muscle 6 amyotrophia nos 6 muscle wasting 6

Diseases related to muscular atrophy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 433)

id	Related Disease	Score	Top Affiliating Genes
1	spinal muscular atrophy	42.5	CNTF, NAIP, LMNA, UTRN, BLZF1, BIRC3
2	spinal-bulbar muscular atrophy	38.0	CHERP, CHKB, SACS, ATXN3, ATXN1, AREGB
3	proximal spinal muscular atrophy	35.2	NAIP, LMNA, VAPB, CHKB, APOE, MAP1B
4	juvenile spinal muscular atrophy	35.0	NAIP, CHKB, SMN1, SMN2
5	x-linked spinal-bulbar muscle atrophy	34.8	AR, SOD1, LYVE1
6	progressive muscular atrophy	34.7	FOLH1, CAV3, AIRE, TRPV4, SMN1, DPP6
7	spinal muscular atrophy type 2	34.1	NCAM1, NAIP, SMN1, SMN2
8	spinal muscular atrophy 1	33.8	VRK1, NAIP, SCO2, GTF2H2, MAP1B, SMN1
9	charcot-marie-tooth disease	32.4	CNTF, LMNA, MTM1, MPZ, HSPB1, HSPB8
10	lateral sclerosis	30.3	CNTF, NAIP, VAPB, UTRN, BCL2, BCL2L1
11	protein s deficiency	29.9	CAV3, GM2A, DMD, SMN1, HADHB, GAA
12	spinal cord disease	29.8	NAIP, IGHMBP2, HNRNPA1, HNRNPA1L2, DDX20, SMN1
13	neuromuscular disease	29.6	NCAM1, NAIP, LMNA, UTRN, CHKB, MTM1
14	amyotrophic lateral sclerosis	29.5	CNTF, NAIP, VAPB, UTRN, BCL2, BCL2L1
15	congenital heart defect	29.4	LMNA, CHKB, CDH2, DMD, DMPK, CS
16	muscular dystrophy	29.4	NCAM1, LMNA, UTRN, CHKB, MSTN, CAV3
17	charcot-marie-tooth neuropathy	29.2	LMNA, MTM1, MPZ, HSPB1, HSPB8, TRPV4
18	myotonic dystrophy type 1	29.2	ATXN1, AR, MBNL1, DMPK, SOD1, RYR1
19	neuronitis	29.0	ZNF259, NCAM1, CNTF, BSCL2, NAIP, LMNA
20	charcot-marie-tooth disease type 2	28.7	LMNA, MPZ, HSPB1, HSPB8, TRPV4, DYNC1H1
21	tooth disease	28.7	CNTF, LMNA, MTM1, MPZ, HSPB1, HSPB8
22	motor neuron disease	28.6	CNTF, BSCL2, NAIP, VAPB, CHAT, ATXN1
23	myotonic dystrophy	28.3	LMNA, BCL2, CHKB, MTM1, CFL1, ATXN3
24	inclusion body myositis	27.8	NCAM1, UTRN, CHKB, CCL4, CCL3, IFNG
25	respiratory failure	27.4	RDH11, CHAT, IL5, IGHMBP2, IFNG, NDUFS4
26	spasticity	27.2	BSCL2, SACS, ATXN3, MPZ, MECP2, CCL3
27	copd	27.0	PARP1, BCL2, MSTN, AREG, IL5, CCL4
28	neurodegenerative disease	26.3	NCAM1, CNTF, NAIP, BLZF1, PARP1, BCL2
29	myasthenia gravis	26.3	NCAM1, UTRN, BCL2, CHAT, CHKB, AR
30	insulin resistance	26.2	CNTF, BSCL2, LMNA, RAB1A, CHKB, MSTN
31	cystic fibrosis	25.8	CHAT, AREG, IL5, FBXO32, CCL4, CCL3
32	neuropathy	25.7	NCAM1, CNTF, BSCL2, NAIP, LMNA, UTRN
33	myopathy	25.7	NCAM1, BSCL2, LMNA, UTRN, BLZF1, BCL2
34	ataxia	25.5	SERF2, BLZF1, BIRC2, KHSRP, PARP1, BCL2
35	myositis	25.5	NCAM1, LMNA, UTRN, BCL2, BCL2L1, CHKB
36	fibrosis	23.9	LMNA, UTRN, BCL2, BCL2L1, CHAT, MSTN
37	prostatitis	21.1	NCAM1, CNTF, RDH11, NAIP, LMNA, RAN
38	hypertrophic cardiomyopathy	14.2	LMNA, SCO2, CHKB, AR, CAV3, DMD
39	mayer-rokitansky-kuster-hauser syndrome	14.2	NAIP, LMNA, PARP1, MTM1, ATP7A, MPZ
40	cytoplasmic body myopathy	14.1	CHKB, DMD, SMN1
41	androgen insensitivity syndrome	14.0	SACS, AREGB, AREG, AR, FDXR, AIS
42	mental retardation syndrome	14.0	ATP7A, AR, MECP2, MAP1B, DMD, SNRPN
43	lower motor neuron disease	14.0	SMN1, SMN2, SOD1
44	virilization	14.0	SACS, AREGB, AREG, AR, FDXR, TP53
45	tay-sachs disease	13.9	GM2A, SMN1, HEXA, NEU1
46	amyotrophic lateral sclerosis (als)	13.9	CNTF, BCL2, BCL2L1, BAD, IGHMBP2, HSPB8
47	mitochondrial encephalomyopathy	13.9	CHKB, COX5A, TK2, GAA
48	polyneuropathy	13.9	CNTF, PARP1, MPZ, APOE, HSPG2, AIRE
49	hypotonia	13.9	LMNA, UBA1, MTM1, ATP7A, MPZ, MECP2
50	motor neuronopathy	13.8	CNTF, ATP7A, AR, IGHMBP2, HSPB1, HSPB3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to muscular atrophy:

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MGI Mouse Phenotypes related to muscular atrophy:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	TRIM63, DMD, SP7, SMN1, NDUFS4, DKC1
2	skeleton phenotype	MP:0005390	10.0	SP7, SNCA, SMN1, NDUFS4, HEXA, TIA1
3	adipose tissue phenotype	MP:0005375	9.8	DMD, SNRPN, TK2, TGFB1, TGFBR2, TARDBP
4	endocrine/exocrine gland phenotype	MP:0005379	9.7	EHD1, TIAL1, SNRPE, DDX20, DMD, AIRE
5	liver/biliary system phenotype	MP:0005370	9.6	TP53, DMD, HEXA, TK2, STAT5A, PRL
6	no phenotypic analysis	MP:0003012	9.6	TP53, DMD, SNCA, SMN1, TARDBP, DKC1
7	nervous system phenotype	MP:0003631	9.6	TK2, NDUFS4, CREB1, SMN1, SNCA, SRSF1
8	embryogenesis phenotype	MP:0005380	9.3	TRA2B, DDX20, SMN1, CREB1, TIAL1, TARDBP
9	hematopoietic system phenotype	MP:0005397	8.9	DMD, TIA1, DKC1, PSMB8, LYVE1, GAPDH
10	immune system phenotype	MP:0005387	8.8	DMD, TP53, AIRE, CAV3, NDUFS4, TIA1
11	integument phenotype	MP:0010771	8.8	TP53, SNCA, SMN1, NDUFS4, TK2, DKC1
12	reproductive system phenotype	MP:0005389	8.7	SNCA, SNRPE, SNRPN, DDX20, DMD, SMN1
13	normal phenotype	MP:0002873	8.7	SNRPN, DMPK, DMD, TP53, TRA2B, AIRE
14	renal/urinary system phenotype	MP:0005367	8.5	PLEKHG5, SNCA, DMD, TP53, HEXA, TGFB1
15	vision/eye phenotype	MP:0005391	8.0	NDUFS4, SRSF1, DMD, TP53, HEXA, TGFB1
16	muscle phenotype	MP:0005369	7.5	GDNF, SMN1, SRSF1, DMPK, DMD, DYNC1H1
17	digestive/alimentary phenotype	MP:0005381	7.5	HSPG2, CASP3, AIRE, TP53, DMD, SNCA
18	cellular phenotype	MP:0005384	7.4	SP7, SNRPN, SNCA, SMN1, CREB1, COIL
19	cardiovascular system phenotype	MP:0005385	7.4	NDUFS4, PLEKHG5, CREB1, SMN1, SNCA, SRSF1
20	behavior/neurological phenotype	MP:0005386	7.2	SNCA, SMN1, CREB1, NDUFS4, HEXA, SNRPN
21	homeostasis/metabolism phenotype	MP:0005376	6.5	HADHB, HEXA, NDUFS4, CREB1, SMN1, SNCA
22	growth/size phenotype	MP:0005378	6.4	TK2, HEXA, NDUFS4, CREB1, SMN1, SNCA
23	mortality/aging	MP:0010768	6.2	SP7, HSPG2, HTT, IFNG, LOX, IGHMBP2

Articles related to muscular atrophy:

(show top 50)    (show all 414)

id	Title	Authors	Year	Affiliating Genes
1	A degron created by SMN2 exon 7 skipping is a princip al contributor to spinal muscular atrophy severity. (20194437)	Cho S.... Dreyfuss G.	2010	SMN1, SMN2
2	Disrupted transforming growth factor-beta signaling i n spinal and bulbar muscular atrophy. (20410122)	Katsuno M.... Sobue G.	2010	TGFBR2, AR, TGFB1
3	CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy. (20234094)	Passini M.A.... Cheng S.H.	2010	SMN1
4	Universal multiplex PCR and CE for quantification of SMN1/SMN2 genes in spinal muscular atrophy. (19373809)	Wang C.C.... Wu S.M.	2009	SMN1, SMN2
5	Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. (19625298)	Mattis V.B.... Lorson C.L.	2009	SMN1
6	Deletion analysis of SMN1 and NAIP genes in Southern Chinese children with spinal muscular atrophy. (19198020)	Liang Y.H.... Zhang X.N.	2009	SMN1, NAIP
7	An analysis of disease severity based on SMN2 copy nu mber in adults with spinal muscular atrophy. (19760790)	Elsheikh B.... Kissel J.T.	2009	SMN2
8	Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy. (19351384)	Millino C.... Lanfranchi G.	2009	SMN1
9	Tetracyclines that promote SMN2 exon 7 splicing as th erapeutics for spinal muscular atrophy. (20161659)	Hastings M.L.... Krainer A.R.	2009	SMN1, SMN2
10	False homozygous deletions of SMN1 exon 7 using Dra I PCR-RFLP caused by a novel mutation in spinal muscular atrophy. (19663601)	Kang S.H.... Park S.S.	2009	SMN1
11	Modeling spinal muscular atrophy in Drosophila. (18791638)	Chang H.C.... Artavanis-Tsakonas S.	2008	SMN1
12	TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy. (18957104)	Turner B.J.... Talbot K.	2008	TARDBP
13	Genetic carrier screening for spinal muscular atrophy and spinal muscular atrophy with respiratory distress 1 in an isolated population in Israel. (18298318)	Basel-Vanagaite L.... Shohat M.	2008	IGHMBP2
14	SMN2 and NAIP gene dosages in Vietnamese patients with spinal muscular atrophy. (18533950)	Tran V.K.... Nishio H.	2008	SMN1, SMN2, NAIP
15	A newborn with spinal muscular atrophy type 0 presenting with a clinicopathological picture suggestive of myotubular myopathy. (18006961)	Nadeau A.... Vanasse M.	2007	MTM1
16	Molecular analysis of the neuronal apoptosis inhibitory protein gene in families with spinal muscular atrophy. (17903057)	Salahshourifar I.... Najmabadi H.	2007	GTF2H2, NAIP
17	Clinical manifestations and molecular genetics of spinal bulbar muscular atrophy: report of 5 cases (17803850)	Li X.H.... Liang Y.X.	2007	CHKB
18	Association of severity of spinal muscular atrophy with the loss of NAIP gene. (16936378)	Singh R.N.	2006	NAIP, LOC647859
19	Detection of homozygous and heterozygous SMN deletions of spinal muscular atrophy in a single assay with multiplex ligation-dependent probe amplification. (15719043)	Tomaszewicz K.... Wu B.L.	2005	SMN1
20	In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement. (16000068)	Sangiuolo F.... Novelli G.	2005	SMN2
21	Analysis of the survival motor neuron and neuronal apoptosis inhibitory protein genes in Malay patients with Spinal Muscular Atrophy. (15779584)	Zilfalil B.A.... Matsuo M.	2004	NAIP
22	Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1. (15116379)	Jinnai K.... Takahashi K.	2004	DMPK
23	Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives. (15133611)	Katsuno M.... Sobue G.	2004	AR
24	Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. (12657679)	Adachi H.... Sobue G.	2003	AR, HSPA8
25	Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). (14526186)	Katsuno M.... Sobue G.	2003	AR
26	Molecular analysis of the spinal muscular atrophy and neuronal apoptosis inhibitory protein genes in Saudi patients with spinal muscular atrophy. (14578966)	al-Jumah M.... Al-Uthaim S.	2003	NAIP
27	Spinal muscular atrophy and mitochondrial DNA depletion. Response to Berber et al. (2003) Acta Neuropathol 105:245-251. (12687391)	Mancuso M.... DiMauro S.	2003	TK2
28	SMN1 gene study in three families in which ALS and spinal muscular atrophy co-exist. (12427909)	Corcia P.... Camu W.	2002	SMN1
29	Spinal muscular atrophy in black South Africans: concordance with the universal SMN1 genotype. (12220455)	Wilmshurst J.M.... Henderson H.E.	2002	SMN1
30	Spinal muscular atrophy genetic testing experience at an academic medical center. (11826188)	Ogino S.... Wilson R.B.	2002	SMN1
31	A novel missense mutation of AIRE gene in a patient with autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED), accompanied with progressive muscular atrophy: case report and review of the literature in Japan. (12625412)	Sato K.... Takano K.	2002	AIRE
32	Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. (11719263)	Beauchemin A.M.... Trifiro M.A.	2001	AR, COX5B, LYVE1
33	Clinical & genetic analysis of four patients with distal upper limb spinal muscular atrophy. (11921836)	Hegde M.R.... Love D.R.	2001	NAIP
34	Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation. (11551898)	Kurihara N.... Reddy S.V.	2001	SMN1, SMN2, OSTF1
35	Diagnostic progress in spinal muscular atrophy (11987841)	Gergont A.... Steczkowska-Klucznik M.	2001	SMN1
36	Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy. (11153908)	Helmken C.... Wirth B.	2000	SMN1, SMN2, TRA2B
37	An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA). (10909848)	Helmken C.... Wirth B.	2000	DDX20, GEMIN2
38	The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body. (10562276)	Carvalho T.... Carmo-Fonseca M.	1999	COIL
39	Transcriptional regulation and subcellular localizat ion of mutant androgen receptor in spinal and bulbar muscular atrophy (10222781)	Miwa S.... Sobue G.	1999	AR
40	High incidence of a survival motor neuron gene/cBCD541 gene ratio of 2 in Japanese parents of spinal muscular atrophy patients: a characteristic background of spinal muscular atrophy in Japan? (9987714)	Nishio H.... Sumino K.	1999	SMN1
41	Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy. (9736019)	Li M.... Sobue G.	1998	AR
42	The survival motor neuron protein in spinal muscular atrophy. (9259265)	Coovert D.D.... Burghes A.H.M.	1997	SMN1, SMN2
43	SMN(T) and NAIP mutations in Canadian families with spinal muscular atrophy (SMA): genotype/phenotype correlations with disease severity. (9295075)	Simard L.R.... Vanasse M.	1997	NAIP
44	Apparent gene conversions involving the SMN gene in the region of the spinal muscular atrophy locus on chromosome 5. (8808598)	van der Steege G.... Buys C.H.	1996	SMN1, SMN2
45	A provisional transcript map of the spinal muscular atrophy (SMA) critical region. (7552146)	van der Steege G.... Buys C.H.C.M.	1995	CFL1, SMN1, SMN2
46	Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. (7731968)	Selig S.... Kunkel L.M.	1995	CDH2, CDH12, CDH12P2
47	SMN gene deletion in variant of infantile spinal muscular atrophy. (7630275)	BA1rglen L.... Melki J.	1995	SMN1
48	X-linked muscular atrophy and the androgen receptor. (18407238)	Trifiro M.A.... Pinsky L.	1994	AR
49	Dominant inherited distal spinal muscular atrophy with atrophic and hypertrophic calves. (8433103)	Groen R.J.... van Weerden T.W.	1993	HSPB8
50	A distal form of chronic spinal muscular atrophy. (5813127)	Meadows J.C.... Marsden C.D.	1969	HSPB8

Genes related to muscular atrophy according to GeneCards:

(show top 50)    (show all 190)

id	Symbol	Description	Score	GeneCards Section Context
1	SMN1	survival of motor neuron 1, telomeric	11.1	Publications, Summaries, Orthologs, Aliases & Descriptions
2	AR	androgen receptor	11.1	Summaries, Aliases & Descriptions, Publications
3	SERF1A	small EDRK-rich factor 1A (telomeric)	11.1	Aliases & Descriptions, Publications, Summaries
4	SMN2	survival of motor neuron 2, centromeric	11.1	Publications, Summaries, Orthologs
5	NAIP	NLR family, apoptosis inhibitory protein	11.1	Publications, Functions, Summaries
6	PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	11.1	Summaries
7	SMALED	Spinal muscular atrophy, lower extremity, autosomal dominant	11.1	Aliases & Descriptions
8	SMAR	Spinal muscular atrophy, chronic distal, autosomal recessive	11.1	Aliases & Descriptions
9	SMAL	spinal muscular atrophy, congenital nonprogressive, of lower limbs	11.1	Aliases & Descriptions
10	GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	11.1	Summaries, Publications
11	DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	11.1	Publications, Summaries
12	AREGB	amphiregulin B	11.1	Summaries
13	SMNDC1	survival motor neuron domain containing 1	11.1	Publications, Summaries
14	KDSR	3-ketodihydrosphingosine reductase	11.1	Publications, Summaries
15	DCTN1	dynactin 1	11.1	Summaries
16	GUSBP4	glucuronidase, beta pseudogene 4	11.1	Aliases & Descriptions
17	GUSBP2	glucuronidase, beta pseudogene 2	11.1	Aliases & Descriptions
18	SCA18	spinocerebellar ataxia 18 (sensory with neurogenic muscular atrophy)	11.1	Aliases & Descriptions
19	UBA1	ubiquitin-like modifier activating enzyme 1	11.0	Publications
20	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	11.0	Publications
21	IGHMBP2	immunoglobulin mu binding protein 2	11.0	Publications, Orthologs
22	GARS	glycyl-tRNA synthetase	11.0	Publications
23	TRPV4	transient receptor potential cation channel, subfamily V, member 4	11.0	Publications
24	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	11.0	Publications
25	MAP1B	microtubule-associated protein 1B	11.0	Publications
26	CHKB	choline kinase beta	11.0	Publications
27	LMNA	lamin A/C	11.0	Publications
28	RAN	RAN, member RAS oncogene family	11.0	Summaries
29	GEMIN2	gem (nuclear organelle) associated protein 2	11.0	Publications, Orthologs
30	SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)	11.0	Publications
31	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	11.0	Publications
32	COIL	coilin	11.0	Publications
33	GAR1	GAR1 ribonucleoprotein homolog (yeast)	11.0	Publications
34	DPP6	dipeptidyl-peptidase 6	11.0	Publications
35	HEXA	hexosaminidase A (alpha polypeptide)	11.0	Publications
36	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
37	TK2	thymidine kinase 2, mitochondrial	11.0	Publications
38	BLZF1	basic leucine zipper nuclear factor 1	11.0	Publications
39	CS	citrate synthase	11.0	Publications
40	COX5A	cytochrome c oxidase subunit Va	11.0	Publications
41	HTT	huntingtin	11.0	Publications
42	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	11.0	Publications
43	HDAC9	histone deacetylase 9	11.0	Publications
44	SOD1	superoxide dismutase 1, soluble	11.0	Publications
45	APOE	apolipoprotein E	11.0	Publications
46	DMD	dystrophin	11.0	Publications
47	CDH12P3	cadherin 12 (N-cadherin 2) pseudogene 3	11.0	Publications
48	LOC646652	integral membrane glycoprotein-like	11.0	Publications
49	CDH12P1	cadherin 12 (N-cadherin 2) pseudogene 1	11.0	Publications
50	CDH12P4	cadherin 12 (N-cadherin 2) pseudogene 4	11.0	Publications

Pathways related to muscular atrophy according to GeneDecks:

(show all 24)

id	Pathway	Score	Top Affiliating Genes
1	mRNA Decay by 5 to 3 Exoribonuclease38	10.9	LSM7, LSM6, LSM5, LSM4, LSM3, LSM1
2	RNA degradation20	10.9	LSM7, LSM6, LSM5, LSM4, LSM3, LSM2
3	mRNA Processing38	10.9	SNRPB, SNRPD3, SNRPE, SNRPG, SNRPF
4	RNA transport20	10.8	GEMIN2, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8
5	Pathogenesis of ALS36	10.5	SLC1A3, SOD1, TP53, CASP3, BAD, BCL2L1
6	Huntingtons disease20	10.3	DCTN1, NDUFS4, COX5B, COX5A, CREB1, TP53
7	Apoptotic Pathways Triggered By HIV136	10.3	TP53, CASP3, BCL2L1, BCL2, BIRC3, BIRC2
8	Amyotrophic lateral sclerosis (ALS)20	10.3	SOD1, TP53, CASP3, BAD, BCL2L1, BCL2
9	Colorectal cancer20	10.3	TGFBR2, TGFB1, TP53, CASP3, APPL1, BAD
10	Spliceosome20	10.2	CHERP, SNRPB, SNRPB2, SMNDC1, LSM2, LSM3
11	Apoptosis20	10.2	TP53, CAPN2, CASP3, BAD, BCL2L1, BCL2
12	Gene Expression38	10.1	GEMIN7, GEMIN6, GEMIN5, TAF9, PHAX, SMN2
13	Apoptosis and survival_FAS signaling cascades41	10.1	BIRC2, PARP1, BCL2, HSPB1, CASP3, LMNA
14	Neuroscience3	10.1	SLC1A3, NCAM1, ATXN1, MECP2, HTT, CAPN2
15	Apoptosis and survival FAS signaling cascades10	10.1	CASP3, HSPB1, BCL2, PARP1, BIRC2, LMNA
16	Apoptosis and Autophagy3	10.1	TIAL1, CASP3, BAD, BCL2L1, BCL2, PARP1
17	Apoptosis Signaling Pathways37	10.0	TP53, CASP3, HSPB1, BAD, BCL2L1, BCL2
18	Processing of Capped Intron-Containing Pre-mRNA38	10.0	LSM2, SNRPB2, SNRPD2, SNRPD1, SRSF1, HNRNPR
19	14-3-3 and Regulation of BAD Activity36	10.0	CASP3, FOXO3, BAD, BCL2L1, BCL2
20	Pathways in cancer20	9.9	STAT5A, TGFBR2, TGFB1, TP53, CASP3, APPL1
21	Alzheimers disease20	9.7	GAPDH, NDUFS4, COX5B, COX5A, SNCA, CAPN2
22	Toxoplasmosis20	9.5	TGFB1, CASP3, HSPA8, IFNG, BAD, BCL2L1
23	Glucocorticoid Receptor Signaling36	9.2	GTF2H2, IL5, CCL4, CCL3, CREB1, TGFB1
24	Ubiquitin mediated proteolysis20	9.0	AIRE, UBE2H, UBE2E2, UBE2E1, UBE2D4, UBA1

Compounds related to muscular atrophy according to GeneDecks:

(show top 50)    (show all 169)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.4	BIRC2, BIRC3, CASP3, TP53
2	n acetylcysteine32	10.3	AREG, AR, APOE, LOX, TP53, SNCA
3	zinc32 18	11.3	ZNF259, LMNA, RAN, UTRN, BLZF1, BIRC2
4	rotenone32	10.2	PARP1, BCL2, BCL2L1, BAD, HSPA8, CASP3
5	kainate32	9.9	NCAM1, CHAT, FOLH1, APOE, HTT, HSPG2
6	agarose32	9.8	BLZF1, BIRC2, PARP1, BCL2, BCL2L1, CHKB
7	ly29400232	9.8	BIRC2, BIRC3, BAD, CCL3, HSPB1, CASP3
8	superoxide32 18	10.6	CNTF, RAN, BLZF1, SCO2, CHKB, CFL1
9	4-hydroxynonenal32 18	10.6	PARP1, CHAT, APOE, HSPA8, CASP3, SNCA
10	glutamate32	9.6	NCAM1, BLZF1, CHAT, MPZ, CDH2, FOLH1
11	alanine32	9.5	NCAM1, CNTF, LMNA, BLZF1, BIRC3, CHAT
12	cisplatin32 34 9 9	12.5	NAIP, RAN, BLZF1, BIRC2, BIRC3, PARP1
13	glycogen32 18	10.5	CHAT, CHKB, BAD, CDH2, FOXO1, FOXO3
14	etoposide32 42 9 9	12.4	BIRC2, BIRC3, PARP1, BCL2, BCL2L1, AR
15	nmda32 42	10.4	NCAM1, BLZF1, BCL2L1, CHAT, CDH2, FOLH1
16	curcumin32	9.4	BIRC2, BIRC3, PARP1, BCL2, BCL2L1, MPZ
17	gemcitabine32 34 9 9	12.4	BIRC3, PARP1, BCL2, BCL2L1, CASP3, TP53
18	h2o232	9.3	CNTF, RAN, BLZF1, BAD, IL5, APOE
19	acetylcholine32 9 18 9	12.3	NCAM1, CNTF, UTRN, BLZF1, CHAT, APOE
20	glucose32	9.2	CNTF, BAD, MSTN, LOX, HSPB1, DMD
21	oxygen32 18	10.2	RAN, BLZF1, BIRC3, PARP1, BCL2, BCL2L1
22	mg 13232 42	10.1	BLZF1, BIRC3, PARP1, BCL2L1, AR, HSPB1
23	lactate32	9.1	NCAM1, BLZF1, CHAT, CHKB, MDH1, CCL3
24	oligonucleotide32	9.1	RAN, BIRC2, BIRC3, BCL2, BCL2L1, CHAT
25	lipid32	9.1	NCAM1, CNTF, LMNA, BLZF1, BIRC3, CHAT
26	creatinine32	9.0	NCAM1, LMNA, UTRN, CHKB, MPZ, APOE
27	pd 98,05932	8.9	CNTF, PARP1, BCL2, BCL2L1, CHAT, BAD
28	atp32	8.9	NCAM1, LMNA, RAN, BLZF1, KHDRBS1, PARP1
29	sb 20358032 42	9.9	BIRC2, BIRC3, PARP1, BCL2, BCL2L1, AREG
30	doxorubicin32 34 9 9	11.8	NCAM1, BIRC2, BIRC3, PARP1, BCL2, BCL2L1
31	glutamine32	8.8	NCAM1, BLZF1, CHERP, CHKB, ATXN3, ATXN1
32	lactacystin32	8.8	PARP1, BCL2, BCL2L1, AR, APOE, IFNG
33	estrogen32	8.7	CHAT, CHKB, CDH2, FOXO1, FOXO3, AREG
34	adenylate32	8.6	CNTF, BLZF1, CHKB, CDH2, AR, IL5
35	nitric oxide32 9 18 9	11.6	NCAM1, CNTF, UTRN, CHAT, CHKB, BAD
36	paraffin32	8.6	NCAM1, BCL2, BCL2L1, CHAT, CHKB, CDH2
37	testosterone32 9 18 9	11.2	NCAM1, CNTF, BLZF1, CHAT, CHERP, CHKB
38	arginine32	8.2	CNTF, LMNA, RAN, UTRN, BLZF1, KHDRBS1
39	butyrate32	8.1	BLZF1, BCL2, BCL2L1, CHAT, IL5, LOX
40	cyclosporin a32 42	9.1	BLZF1, CHKB, BAD, IL5, APOE, CCL4
41	actinomycin d32	7.9	CNTF, BLZF1, BIRC2, BIRC3, PARP1, BCL2
42	rapamycin32 42	8.7	MSTN, FOXO1, FOXO3, AR, FBXO32, IFNG
43	tacrolimus32 34 9 9	10.4	CHKB, BAD, IL5, CCL4, CCL3, IFNG
44	cysteine32	7.0	NAIP, RAN, BLZF1, PARP1, BCL2L1, CHKB
45	retinoic acid32 42 18	8.9	NCAM1, CNTF, LMNA, BLZF1, PARP1, BCL2L1
46	serine32	6.8	NCAM1, CNTF, LMNA, BLZF1, BIRC3, KHDRBS1
47	tyrosine32	6.8	NCAM1, CNTF, RAN, UTRN, BLZF1, BIRC3
48	dexamethasone32 42 34 9 9	10.8	NCAM1, BIRC2, BIRC3, PARP1, BCL2, BCL2L1
49	cycloheximide32	6.5	CNTF, BLZF1, BIRC2, BIRC3, PARP1, BCL2
50	vegf32	6.3	NCAM1, CNTF, BIRC2, PARP1, BCL2, BCL2L1

Cellular components related to muscular atrophy according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	small nuclear ribonucleoprotein complex	GO:030532	10.8	GEMIN4, TGS1, LSM6, LSM4, SNRPB, SNRPD3
2	U12-type spliceosomal complex	GO:005689	10.8	RNPC3, SNRPB, SNRPD3, SNRPE, SNRPG, SNRPD2
3	U7 snRNP	GO:005683	10.6	SNRPB, SNRPD3, SNRPE, SNRPG, SNRPF
4	Cajal body	GO:015030	10.5	GEMIN8, GEMIN7, GEMIN6, GEMIN5, GEMIN4, GEMIN2
5	SMN complex	GO:032797	10.3	IGHMBP2, GEMIN7, GEMIN8
6	axon	GO:030424	10.3	TGFB1, SNCA, HTT, IGHMBP2, MAP1B, AR
7	spliceosomal complex	GO:005681	10.1	HNRNPA1L2, HNRNPA1, HSPA8, HNRNPC, GEMIN4, GEMIN2
8	catalytic step 2 spliceosome	GO:071013	10.0	SNRPD3, SNRPE, SNRPG, SNRPD2, SNRPF, SNRPD1
9	ribonucleoprotein complex	GO:030529	9.9	SYNCRIP, LSM7, LSM5, LSM1, HNRNPR, HNRNPA1
10	nucleolus	GO:005730	8.7	AIRE, TP53, DDX41, CREB1, NOLC1, COIL
11	nucleoplasm	GO:005654	8.4	PHAX, COIL, RPS27A, CREB1, SMN2, SNRPB2
12	cytosol	GO:005829	8.0	GEMIN7, GEMIN6, GEMIN5, GEMIN4, GEMIN2, GAPDH
13	nucleus	GO:005634	6.7	SNCA, SMNDC1, CREB1, COIL, RNPC3, LSM1
14	cytoplasm	GO:005737	5.8	STAT5A, DYNC1H1, TP53, TRIM63, AIRE, HNRNPR

Biological processes related to muscular atrophy according to GeneDecks:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	spliceosomal complex assembly	GO:000245	11.0	GEMIN6, GEMIN2, SMN2, SNRPE, SNRPG, SNRPD2
2	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	GO:043928	11.0	LSM7, LSM6, LSM5, LSM4, LSM3, LSM2
3	ncRNA metabolic process	GO:034660	11.0	GEMIN7, SNRPD1, SNUPN, DDX20, SNRPF, SNRPD2
4	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO:000288	10.9	LSM7, LSM6, LSM5, LSM4, LSM3, LSM2
5	histone mRNA metabolic process	GO:008334	10.9	SNRPB, SNRPD3, SNRPE, SNRPG, SNRPF
6	spliceosomal snRNP assembly	GO:000387	10.9	GEMIN8, GEMIN7, GEMIN6, GEMIN5, GEMIN4, GEMIN2
7	RNA splicing, via transesterification reactions	GO:000375	10.9	GEMIN2, LSM1, SMNDC1, TRA2B, KHSRP
8	lipid storage	GO:019915	10.6	STAT5A, HEXA, GM2A, BSCL2
9	regulation of mitochondrial membrane potential	GO:051881	10.6	SOD1, HTT, BCL2L1, BCL2
10	regulation of mitochondrial membrane permeability	GO:046902	10.6	TP53, HTT, BAD, BCL2L1, BCL2
11	negative regulation of neuron apoptotic process	GO:043524	10.6	GDNF, SOD1, SNCA, HTT, MECP2, BCL2L1
12	termination of RNA polymerase II transcription	GO:006369	10.6	SNRPB, SNRPD3, SNRPE, SNRPG, SNRPF, SRSF1
13	release of cytochrome c from mitochondria	GO:001836	10.4	TIMM50, TP53, CASP3, ATP7A, BCL2L1, BCL2
14	phospholipid metabolic process	GO:006644	10.4	HADHB, NEU1, HEXA, SNCA, GM2A, MTM1
15	T cell homeostasis	GO:043029	10.2	STAT5A, TGFB1, CASP3, BCL2
16	cellular calcium ion homeostasis	GO:006874	10.1	VAPB, CHERP, CCL3, TRPV4, DMPK, TGFB1
17	RNA processing	GO:006396	10.1	DKC1, SYNCRIP, DDX41, DDX20, ATXN1, CHERP
18	RNA metabolic process	GO:016070	10.1	SNRPE, SNRPG, SNRPD2, SNRPF, SNRPD1, SNUPN
19	nuclear mRNA splicing, via spliceosome	GO:000398	10.1	SRSF1, DDX41, TRA2B, HNRNPR, HNRNPC, HNRNPA1
20	neuron apoptotic process	GO:051402	10.1	GAPDH, TP53, CASP3, HTT, BCL2
21	mRNA processing	GO:006397	10.1	SNRPB2, SNRPB, SNRPD3, SNRPE, SNRPG, SNRPF
22	mRNA metabolic process	GO:016071	9.9	PSMB8, LSM7, LSM6, LSM5, LSM4, LSM3
23	cell death	GO:008219	9.9	DYNC1H1, TRPV4, HSPB8, HSPB3, HSPB1, IGHMBP2
24	virus-host interaction	GO:019048	9.9	KPNB1, TOP1, TGFB1, SYNCRIP, PSMB8, CREB1
25	RNA splicing	GO:008380	9.9	SNRPB2, SNRPB, SNRPD3, SNRPE, SNRPG, SNRPD2
26	transforming growth factor beta receptor signaling pathway	GO:007179	9.8	STRAP, TGFBR2, TGFB1, RPS27A, CREB1, TP53
27	small molecule metabolic process	GO:044281	9.7	ACAT1, HEXA, TK2, TGS1, DGUOK, PSMB8
28	anti-apoptosis	GO:006916	9.6	HTT, HSPB1, SNCA, RPS27A, SOD1, GDNF
29	response to drug	GO:042493	9.4	SLC1A3, SOD1, TGFBR2, TGFB1, TOP1, CREB1
30	gene expression	GO:010467	9.2	GEMIN2, GARS, PSMB8, TAF9, TGS1, LSM7
31	apoptotic process	GO:006915	8.4	DDX41, SMNDC1, PLEKHG5, RPS27A, KPNB1, TIA1

Molecular functions related to muscular atrophy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:005507	10.3	SCO2, ATP7A, LOX, TP53, SNCA, SOD1
2	RNA binding	GO:003723	9.2	SNRPE, SMN2, SMNDC1, PHAX, RNPC3, LSM1
3	nucleotide binding	GO:000166	9.1	SNRPB2, RNPC3, TIA1, TIAL1, TARDBP, SYNCRIP
4	protein binding	GO:005515	4.9	CREB1, TARDBP, SYNCRIP, DKC1, STAT5A, STRAP