MCID: MTG002
MIFTS: 40

Mutagen Sensitivity malady

Summaries for Mutagen Sensitivity

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33MalaCards
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MalaCards: Mutagen Sensitivity is related to squamous cell carcinoma and oral cancer. An important gene associated with Mutagen Sensitivity is XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3), and among its related pathways are DNA Damage Recognition in GG-NER and Fluoropyrimidine Pathway, Pharmacodynamics. The compounds manganese superoxide and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Mutagen Sensitivity

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43NIH Rare Diseases
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Aliases & Descriptions:

mutagen sensitivity 43


Related Diseases for Mutagen Sensitivity

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.6XRCC1, XRCC3, FANCG, XPA, XPC, DNMT3B
2oral cancer30.3GSTT1, GSTM1
3ataxia telangiectasia30.1XRCC1, XRCC3, XPA, TOPBP1, BLM, DNMT1
4colorectal cancer30.1XRCC1, XRCC3, XPC, DNMT3B, DNMT1, NAT2
5radiation induced cancer10.2
6sporadic breast cancer10.1
7barrett's esophagus10.1
8n syndrome10.1
9soft tissue sarcoma10.1
10cutaneous malignant melanoma10.1
11ataxia10.1
12cytomegalovirus infection10.1
13lung cancer susceptibility10.1
14meningioma10.0GSTT1
15infertility10.0GSTT1
16multiple sclerosis10.0GSTM1
17malignant glioma10.0DNMT3B
18myeloid leukemia10.0DNMT1
19malignant mesothelioma10.0NAT2
20spina bifida10.0NAT2
21primary open angle glaucoma10.0GSTM1
22sarcoma10.0GSTM1
23lupus erythematosus10.0NAT2
24leukoplakia10.0GSTT1, GSTM1
25laryngeal carcinoma10.0GSTT1, NAT2
26motor neuron disease10.0GSTT1
27brain cancer10.0GSTM1, GSTT1
28bloom syndrome10.0MUS81, BLM
29cataract10.0GSTT1, NAT2
30testicular cancer10.0ERCC2, DNMT1
31cervical cancer10.0XRCC1, GSTM1, GSTT1
32endometriosis10.0GSTT1, GSTM1, NAT2
33thyroid cancer10.0GSTT1, GSTM1
34deficiency anemia10.0FANCG, DNMT1, GSTM1
35photosensitive trichothiodystrophy10.0XPA, ERCC5, ERCC2
36familial adenomatous polyposis10.0NAT2, DNMT1
37immunodeficiency, centromere instability and facial anomalies syndrome10.0DNMT1, DNMT3B
38skin benign neoplasm10.0ERCC2, XPC, XPA
39astrocytoma10.0XPC, ERCC2, GSTT1
40acute lymphoblastic leukemia, childhood10.0XRCC1, GSTM1, GSTT1
41hepatitis10.0REV3L, NAT2, GSTT1
42open-angle glaucoma10.0GSTM1, GSTT1
43laryngeal squamous cell carcinoma10.0GSTT1, GSTM1, NAT2
44pancreatic cancer10.0XRCC1, FANCG, DNMT1, NAT2
45skin cancer10.0XRCC1, XRCC3, XPA, XPC, ERCC2
46bladder carcinoma10.0NAT2, GSTM1, GSTT1
47acute leukemia10.0GSTT1, GSTM1, DNMT1, DNMT3B
48lung adenocarcinoma10.0GSTT1, GSTM1, XPA, XRCC1
49squamous cell carcinoma of the head and neck10.0XRCC1, FANCG, DNMT3B, GSTM1, GSTT1
50lung cancer10.0XRCC1, XRCC3, DNMT3B, ERCC2, GSTM1

Graphical network of the top 20 diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Clinical Features for Mutagen Sensitivity

Drugs & Therapeutics for Mutagen Sensitivity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Mutagen Sensitivity

Search CenterWatch for Mutagen Sensitivity

Genetic Tests for Mutagen Sensitivity

Anatomical Context for Mutagen Sensitivity

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33MalaCards
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MalaCards organs/tissues related to Mutagen Sensitivity:

33
Colon, Liver, Lung, Breast, Skin

Animal Models for Mutagen Sensitivity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Mutagen Sensitivity

Sources:
51PubMed
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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. (21164199)
2011
2
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
3
Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer. (20400363)
2010
4
A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens. (20106949)
2010
5
Chromosomal alterations and mutagen sensitivity in human mucosal cells of the oropharynx and lymphocytes caused by BPDE. (19996129)
2009
6
Mutagen sensitivity: a genetic predisposition factor for cancer. (17440053)
2007
7
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)
2007
8
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay. (16537698)
2006
9
Reliability of mutagen sensitivity assay: an inter-laboratory comparison. (16870697)
2006
10
Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer. (16703596)
2006
11
Mutagen sensitivity of patients with cancer at different sites of the head and neck. (16105906)
2005
12
Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy. (16015542)
2005
13
Inter-rater agreement on chromosome 5 breakage in FISH-based mutagen sensitivity assays (MSAs). (15279836)
2004
14
Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. (15205461)
2004
15
Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. (15199548)
2004
16
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. (12611459)
2003
17
From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. (12893086)
2003
18
Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk. (12407747)
2003
19
Construction of green fluorescent protein reporter genes for genotoxicity test (SOS/umu-test) and improvement of mutagen-sensitivity. (16233101)
2001
20
Mutagen sensitivity as an indicator of soft tissue sarcoma risk. (11746758)
2001
21
Mutagen sensitivity and p53 expression in colorectal cancer in China. (11677281)
2001
22
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10984281)
2000
23
Mutagen sensitivity in patients with familial and non-familial urothelial cell carcinoma. (11054683)
2000
24
Saturation mutagenesis of the haloarchaeal bop gene promoter: identification of DNA supercoiling sensitivity sites and absence of TFB recognition element and UAS enhancer activity. (10844701)
2000
25
Environmental tobacco smoking, mutagen sensitivity, and head and neck squamous cell carcinoma. (11045786)
2000
26
Mutagen sensitivity and environmental exposures as contributing causes of chromosome 3p losses in head and neck cancers. (10837016)
2000
27
Family history of cancer, mutagen sensitivity, and increased risk of head and neck cancer. (10656614)
1999
28
Mutagen sensitivity in common cutaneous malignant melanoma and dysplastic naevus syndrome. (10465585)
1999
29
Mutagen sensitivity as a predictor of tumor recurrence in patients with cancer of the upper aerodigestive tract. (9462683)
1998
30
Gamma-ray mutagen sensitivity and survival in patients with glioma. (9865917)
1998
31
DNA repair and mutagen sensitivity in patients with triple primary cancers. (9568788)
1998
32
Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer. (9298575)
1997
33
A clinical trial to evaluate the effect of vitamin C supplementation on in vitro mutagen sensitivity. The University of Texas M. D. Anderson Clinical Community Oncology Program Network. (9232342)
1997
34
Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. (7603995)
1995
35
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. (7537995)
1995
36
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. (7907981)
1994
37
Mutagen sensitivity as a marker of cancer risk. (7526974)
1994
38
Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. (7509776)
1994
39
Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. (7682127)
1993
40
Mutagen sensitivity: a biological marker of cancer susceptibility. (1726967)
1991
41
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. (1700135)
1990
42
Mutagen sensitivity and cancer susceptibility. Report of a cancer-prone family. (2476211)
1989
43
Normal sensitivity to mutagens, spontaneous chromosome breakage, and mutation frequency in nevoid basal cell carcinoma syndrome. (3408258)
1988
44
Genetic predisposition to cancer with special reference to mutagen sensitivity. (3308827)
1987
45
Mutagen sensitivity, smoking habits and enzyme induction in healthy middle-aged men. (6150846)
1984
46
Mutagen sensitivity of Neurospora meiotic mutants. (6220799)
1983
47
Mutagen sensitivity of Drosophila melanogaster. VI. Evidence from the excision-defective mei-9AT1 mutant for the timing of DNA-repair activity during spermatogenesis. (6403842)
1983
48
Mutant Gene snm2-1 (ts), conferring thermoconditional mutagen sensitivity in Saccharomyces cerevisiae, is allelic with RAD5. (24186224)
1982
49
Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methyl methanesulfonate. (189178)
1976
50
Mutagen sensitivity of Drosophila melanogaster. I. Isolation and preliminary characterization of a methyl methanesulphonate-sensitive strain. (4356741)
1973

Genetic Variations for Mutagen Sensitivity

Expression for genes affiliated with Mutagen Sensitivity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutagen Sensitivity

Search GEO for disease gene expression data for Mutagen Sensitivity.

Pathways for genes affiliated with Mutagen Sensitivity

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Mutagen Sensitivity

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1manganese superoxide4510.5GSTT1
2methylchloride4510.4GSTM1, GSTT1
3n-(2-hydroxyethyl)valine4510.4GSTM1, GSTT1
4trans,trans-muconic acid4510.4GSTM1, GSTT1
5s-phenylmercapturic acid4510.4GSTT1, GSTM1
6hema4510.4GSTT1, GSTM1
7polyvinyl chloride4510.4XRCC1, GSTT1
8styrene oxide4510.4GSTT1, GSTM1
92-naphthol4510.4GSTM1, GSTT1
10ethylene oxide4510.4GSTM1, GSTT1
11butadiene monoxide4510.4GSTM1, GSTT1
121,3-butadiene4510.3GSTT1, GSTM1
13zebularine4510.3DNMT3B, DNMT1
14cumene hydroperoxide4510.3GSTM1, GSTT1
15vinylchloride4510.3XRCC1, GSTM1, GSTT1
168-oxoguanine4510.3XRCC1, GSTM1, GSTT1
17platinum45 5011.3XRCC1, GSTT1, ERCC2
18drugs for treatment of tuberculosis5010.2GSTT1, NAT2, GSTM1
19arylamine4510.2NAT2, GSTT1, GSTM1
201-hydroxypyrene4510.2GSTT1, NAT2, GSTM1
213-deazaneplanocin a hydrochloride6010.2DNMT1, DNMT3B
22styrene4510.2NAT2, GSTM1, GSTT1
23trichloroethylene4510.2GSTT1, NAT2, GSTM1
24benzidine4510.2GSTM1, NAT2, GSTT1
25isoniazid50 45 1112.2GSTM1, NAT2, GSTT1
26sgc 09466010.2DNMT1, DNMT3B
27aflatoxin b145 2411.2GSTT1, GSTM1, NAT2
28rsai4510.2NAT2, GSTM1, GSTT1
29bix 012946010.2DNMT1, DNMT3B
30p0034510.1XRCC3, XRCC1, GSTM1, GSTT1
31unc 06386010.1DNMT1, DNMT3B
322-acetylaminofluorene4510.1XPC, XPA
33unc 06466010.1DNMT1, DNMT3B
34gsts4510.1GSTM1, GSTT1, XRCC1, NAT2
35betacarotene4510.1NAT2, GSTM1, XRCC1
36epoxide4510.1XRCC1, GSTT1, NAT2, GSTM1
37ecteinascidin 7434510.0ERCC5, ERCC2
38cyclophosphamide45 50 1112.0XRCC1, ERCC2, GSTT1, GSTM1
39hydrocarbons4510.0NAT2, ERCC2, GSTM1, GSTT1
40benzene459.9GSTT1, GSTM1, NAT2, XRCC1, XRCC3
41diepoxybutane459.9NAT2, XRCC1, GSTM1, GSTT1, FANCG
42oxaliplatin45 50 1111.9ERCC2, XPA, GSTM1, XRCC1, GSTT1
43cotinine45 2410.8ERCC2, GSTM1, XRCC1, NAT2, GSTT1
44platinum compounds509.8XRCC1, ERCC2
45cadmium45 2410.7XRCC1, XPA, DNMT1
46benzo(a)pyrene459.7GSTT1, GSTM1, NAT2, XPC, XPA, XRCC1
47mspi459.5GSTT1, GSTM1, ERCC2, NAT2, DNMT1, XRCC1
48oligonucleotide459.3XRCC1, XPA, GSTT1, DNMT3B, DNMT1, ERCC5
49folate459.2DNMT1, DNMT3B, XRCC3, GSTT1, GSTM1, ERCC2
50cisplatin45 50 60 1111.7ERCC2, XRCC3, FANCG, XPA, XPC, DNMT1

GO Terms for genes affiliated with Mutagen Sensitivity

Sources:
16Gene Ontology
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Cellular components related to Mutagen Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.1RAD23B, XPC
2male germ cell nucleusGO:00167310.0TOPBP1, BLM
3holo TFIIH complexGO:0056759.9ERCC2, ERCC5
4replication forkGO:0056579.6DNMT1, BLM
5nucleoplasmGO:0056548.9FANCG, XRCC1, ERCC2, ERCC5, RAD23B, POLQ
6nucleusGO:0056347.7XRCC1, XRCC3, XPA, XPC, TOPBP1, ERCC2

Biological processes related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.3RAD23B, XPC
2regulation of mitotic cell cycle phase transitionGO:190199010.2ERCC2, XPC
3negative regulation of histone H3-K9 methylationGO:05157310.1DNMT3B, DNMT1
4positive regulation of histone H3-K4 methylationGO:05157110.0DNMT3B, DNMT1
5DNA methylationGO:00630610.0DNMT3B, DNMT1
6UV protectionGO:0096509.9ERCC5, ERCC2
7DNA recombinationGO:0063109.8XRCC3, BLM, MUS81
8nucleotide-excision repair, DNA damage removalGO:0007189.7XPA, XPC, RAD23B, ERCC5, ERCC2
9nucleotide-excision repairGO:0062899.7XPC, XPA, RAD23B, ERCC5, ERCC2
10response to drugGO:0424939.5XPC, XRCC1, BLMH, GSTT1
11DNA repairGO:0062818.0MUS81, XPA, XPC, TOPBP1, POLQ, BLM

Molecular functions related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA-methyltransferase activityGO:00900810.0DNMT1, DNMT3B
2bubble DNA bindingGO:0004059.9XPC, ERCC5, BLM
3DNA (cytosine-5-)-methyltransferase activityGO:0038869.9DNMT3B, DNMT1
4single-stranded DNA bindingGO:0036979.7XPC, BLM, ERCC5, RAD23B
5damaged DNA bindingGO:0036849.5RAD23B, XRCC1, FANCG, XPA, XPC, POLQ
6ATP-dependent helicase activityGO:0080269.4HELQ, POLQ, BLM
7DNA bindingGO:0036778.8XRCC3, ERCC2, REV3L, DNMT1, MUS81, TOPBP1
8protein bindingGO:0055157.3ERCC5, RAD23B, REV3L, DNMT1, DNMT3B, XPA

Products for genes affiliated with Mutagen Sensitivity

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Sources for Mutagen Sensitivity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet