MCID: MTG002
MIFTS: 35

Mutagen Sensitivity malady

Category: Rare diseases

Aliases & Classifications for Mutagen Sensitivity

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Aliases & Descriptions for Mutagen Sensitivity:

Name: Mutagen Sensitivity 46

Classifications:



Summaries for Mutagen Sensitivity

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MalaCards based summary: Mutagen Sensitivity is related to nasopharyngeal carcinoma and breast cancer. An important gene associated with Mutagen Sensitivity is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways are DNA Damage Induced 14-3-3Sigma Signaling and Resolution of D-Loop Structures. Affiliated tissues include lung, breast and testes, and related mouse phenotypes are pigmentation and embryo.

Related Diseases for Mutagen Sensitivity

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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngeal carcinoma29.3BRCA1, BRCA2, TP53, XPC
2breast cancer27.9BRCA1, BRCA2, CCND1, DNMT3B, IGF1, NAT2
3lung cancer27.9CCND1, DNMT1, ERCC2, GSTM1, GSTT1, TP53
4colorectal cancer26.6BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, GSTM1
5congenital pulmonary veins atresia or stenosis10.7BRCA1, BRCA2
6bronchopulmonary dysplasia10.6BRCA1, BRCA2
7cutaneous lupus erythematosus10.6BRCA1, BRCA2
8autoimmune disease of blood10.6BRCA1, BRCA2
9selective ige deficiency disease10.6BRCA1, BRCA2
10familial breast cancer10.6BRCA1, BRCA2
11breast cancer, childhood10.6BRCA1, BRCA2
12lethal congenital contracture syndrome 710.6BRCA1, BRCA2
13emery-dreifuss muscular dystrophy, dominant type10.5GSTM1, GSTT1, NAT2
14diplegia of upper limb10.5GSTM1, GSTT1, NAT2
15fat necrosis of breast10.4BRCA1, BRCA2
16cervical serous adenocarcinoma10.4BRCA1, BRCA2, TP53
17ovarian brenner tumor10.4BRCA1, BRCA2, TP53
18rectum mucinous adenocarcinoma10.4BRCA1, BRCA2, TP53
19papillary adenofibroma10.3BRCA1, BRCA2, TP53
20apocrine adenosis of breast10.3CCND1, XRCC1
21mixed cerebral palsy10.3BRCA2, TP53, XRCC1
22leiomyosarcoma10.3BRCA1, BRCA2, TP53
23distal monosomy 9p10.3BRCA1, BRCA2, TP53
24fallopian tube germ cell cancer10.3BRCA1, BRCA2
25dental caries10.3BRCA1, BRCA2, TP53
26visual cortex disease10.3BRCA1, BRCA2, TP53
27amyloid tumor10.3BRCA1, BRCA2, CCND1
28milker's nodule10.3BRCA1, BRCA2, TP53
29ovarian wilms' cancer10.3BRCA1, BRCA2, TP53
30lung carcinoma in situ10.3BRCA1, BRCA2, TP53
31adrenal cortical carcinoma10.3GSTM1, TP53, XRCC1
32tumor predisposition syndrome10.3BRCA1, BRCA2, TP53
33oral pharyngeal disorders10.2GSTM1, GSTT1, TP53, XRCC1
34acute myocardial infarction10.2GSTM1, GSTT1, TP53
35levic stefanovic nikolic syndrome10.2GSTM1, GSTT1, TP53, XRCC1
36laryngeal benign neoplasm10.1GSTM1, GSTT1, NAT2, XRCC1, XRCC3
37congenital hypomyelination neuropathy10.0IGF1, TP53, XRCC1, XRCC3
38chondroma10.0CCND1, GSTM1, GSTT1, TP53
39melanoma10.0
40male reproductive organ benign neoplasm10.0CCND1, IGF1, TP53
41cerebellar vermis medulloblastoma10.0CCND1, IGF1, TP53
42myelodysplastic syndrome10.0DNMT1, DNMT3B, GSTM1, GSTT1
43pineal region meningioma10.0BRCA1, BRCA2, GSTM1, TP53, XRCC1
44ductal carcinoma in situ9.9BRCA1, BRCA2, CCND1, TP53
45cervical cancer, somatic9.9CCND1, GSTM1, GSTT1, TP53
46estrogen-receptor negative breast cancer9.9BRCA1, BRCA2, CCND1, TP53
47short-rib thoracic dysplasia 3 with or without polydactyly9.9BRCA1, BRCA2, TP53
48trachea sarcoma9.9BRCA1, BRCA2, CCND1, TP53
493-methylglutaconic aciduria, type i9.9XPA, XPC
50nasopharyngitis9.9

Graphical network of the top 20 diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Symptoms for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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Interventional clinical trials:

idNameStatusNCT IDPhase
1DNA Repair, p53 and Apoptosis Phenotypes in Lung CancerRecruitingNCT00339859
2Genetic Susceptibility to Bladder CancerRecruitingNCT00848289

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Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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MalaCards organs/tissues related to Mutagen Sensitivity:

34
Lung, Breast, Testes, Skin, Colon

Animal Models for Mutagen Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Mutagen Sensitivity:

39 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7BRCA1, DNMT1, ERCC2, TP53, XPA
2MP:00053808.5BRCA1, BRCA2, DNMT1, DNMT3B, RAD23B, TP53
3MP:00053718.1BLMH, BRCA1, BRCA2, IGF1, TP53, XPA
4MP:00053757.9BRCA1, ERCC2, IGF1, RAD23B, TP53, XPA
5MP:00028737.8BRCA1, BRCA2, CCND1, DNMT1, IGF1, RAD23B
6MP:00053907.0BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
7MP:00053916.9CCND1, DNMT3B, ERCC2, RAD23B, TP53, XPA
8MP:00053976.8BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
9MP:00053796.6BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
10MP:00053896.3BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
11MP:00020066.2BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
12MP:00107716.2BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
13MP:00053876.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
14MP:00036316.1BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
15MP:00053865.8BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
16MP:00053845.7BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
17MP:00053765.3BLMH, BRCA1, BRCA2, CCND1, ERCC2, IGF1
18MP:00053785.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
19MP:00107685.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Publications for Mutagen Sensitivity

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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension. (25918951)
2015
2
Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk. (24623229)
2014
3
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. (21164199)
2011
4
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
5
Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer. (20400363)
2010
6
Mutagen sensitivity: a genetic predisposition factor for cancer. (17440053)
2007
7
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)
2007
8
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. (17035402)
2006
9
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay. (16537698)
2006
10
DNA damage, oxidative mutagen sensitivity, and repair of oxidative DNA damage in nonmelanoma skin cancer patients. (16673411)
2006
11
High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy. (15837739)
2005
12
Differential mutagen sensitivity of peripheral blood lymphocytes from smokers and nonsmokers: effect of human cytomegalovirus infection. (15065204)
2004
13
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study. (14757193)
2004
14
Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. (15450412)
2004
15
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. (12611459)
2003
16
Mutagen sensitivity as a susceptibility marker for endometriosis. (14507820)
2003
17
From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. (12893086)
2003
18
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10984281)
2000
19
Mutagen sensitivity as a biomarker for second primary tumors after head and neck squamous cell carcinoma. (10919742)
2000
20
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. (11173867)
2000
21
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10793110)
2000
22
Family history of cancer, mutagen sensitivity, and increased risk of head and neck cancer. (10656614)
1999
23
Genetics of smoking-related cancer and mutagen sensitivity. (10393708)
1999
24
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. (9676854)
1998
25
Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma. (9681523)
1998
26
Gamma-ray mutagen sensitivity and survival in patients with glioma. (9865917)
1998
27
Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells. (9624737)
1997
28
Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer. (9298575)
1997
29
Mutagen sensitivity and risk of gliomas: a case-control analysis. (8603389)
1996
30
Lack of effect of daily N-acetylcysteine supplementation on mutagen sensitivity. (8922306)
1996
31
Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. (7541679)
1995
32
Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck. (7539412)
1995
33
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. (7537995)
1995
34
Mutagen sensitivity and cancer susceptibility in patients with multiple primary cancers. (21597846)
1995
35
Mitotic catastrophe is the mechanism of lethality for mutations that confer mutagen sensitivity in Aspergillus nidulans. (7506362)
1994
36
Mutagen sensitivity as a marker of cancer risk. (7526974)
1994
37
Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. (7509776)
1994
38
Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract. (7966395)
1994
39
Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. (7688625)
1993
40
A novel phenotype of an excision-repair mutant in Neurospora crassa: mutagen sensitivity of the mus-18 mutant is specific to UV. (1832207)
1991
41
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. (1700135)
1990
42
Mutagen sensitivity and mutability in lentil. (24247709)
1986
43
Mutagen sensitivity of Drosophila melanogaster. VIII. The influence of the mei-41D5, mus(1)101D1, mus(1)102D1, mus(1)103D1, mus(2)205A1, and mus(3)310D1 loci on alkylation-induced mutagenesis. (3923336)
1985
44
Mutagen sensitivity of Drosophila melanogaster: VII. Alkylation mutagenesis of mature and immature oocytes of the excision-deficient mus (2) 201D1 mutant. (6434298)
1984
45
Mutagen sensitivity, smoking habits and enzyme induction in healthy middle-aged men. (6150846)
1984
46
Biochemical genetics of Neurospora nuclease II: Mutagen sensitivity and other characteristics of the nuclease mutants. (6309614)
1983
47
Mutagen sensitivity of Neurospora meiotic mutants. (6220799)
1983
48
Genetic control of mutagen sensitivity in Drosophila melanogaster: a new allele at the mei-9 locus on the X-chromosome. (107445)
1979
49
Mutagen sensitivity of wild type and recombination deficient c(3)G strains of Drosophila melanogaster. (121955)
1978
50
Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa. (188973)
1977

Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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Search GEO for disease gene expression data for Mutagen Sensitivity.

Pathways for genes affiliated with Mutagen Sensitivity

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Pathways related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.8BRCA1, TP53
2
Show member pathways
9.7BRCA1, BRCA2, XRCC3
3
Show member pathways
9.5BRCA1, BRCA2, TP53
49.5BRCA2, CCND1, XRCC1
59.4BRCA1, CCND1, TP53
69.4BRCA1, CCND1, TP53
79.3CCND1, DNMT1, TP53
89.2CCND1, IGF1, TP53
99.0BRCA1, CCND1, IGF1, TP53
10
Show member pathways
9.0BRCA1, CCND1, IGF1, TP53
118.8BRCA1, BRCA2, CCND1, TP53, XRCC3
12
Show member pathways
8.7BRCA1, BRCA2, CCND1, IGF1, TP53
138.7BRCA1, BRCA2, CCND1, IGF1, TP53
148.7BRCA1, CCND1, DNMT1, DNMT3B, TP53
158.7ERCC2, GSTM1, GSTT1, XPA
168.1ERCC2, TP53, XPA, XPC
17
Show member pathways
8.0ERCC2, RAD23B, XPA, XPC
18
Show member pathways
7.8ERCC2, RAD23B, XPA, XPC, XRCC1
196.7BRCA1, CCND1, ERCC2, RAD23B, TP53, XPA
20
Show member pathways
6.6BRCA1, BRCA2, ERCC2, RAD23B, TP53, XPA
21
Show member pathways
6.0BRCA1, BRCA2, CCND1, ERCC2, IGF1, RAD23B

GO Terms for genes affiliated with Mutagen Sensitivity

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Cellular components related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:007194210.0RAD23B, XPC
2replication forkGO:000565710.0DNMT1, TP53, XRCC3
3nucleusGO:00056345.2BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
4nucleoplasmGO:00056545.1BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
5cytoplasmGO:00057375.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Biological processes related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1chromosome breakageGO:003105210.6BRCA1, BRCA2
2chordate embryonic developmentGO:004300910.6BRCA1, BRCA2
3positive regulation of protein import into nucleus, translocationGO:003316010.5BRCA1, IGF1
4mitotic G1 DNA damage checkpointGO:003157110.2CCND1, TP53
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2BRCA1, BRCA2, TP53
6S-adenosylhomocysteine metabolic processGO:004649810.2DNMT1, DNMT3B
7strand displacementGO:000073210.1BRCA1, BRCA2, XRCC3
8DNA synthesis involved in DNA repairGO:000073110.1BRCA1, BRCA2, XRCC3
9C-5 methylation of cytosineGO:009011610.1DNMT1, DNMT3B
10double-strand break repair via homologous recombinationGO:000072410.1BRCA1, BRCA2, XRCC1, XRCC3
11response to nutrientGO:000758410.1BRCA1, BRCA2, IGF1
12S-adenosylmethioninamine metabolic processGO:004649910.1DNMT1, DNMT3B
13DNA methylation on cytosine within a CG sequenceGO:001042410.1DNMT1, DNMT3B
14intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.0BRCA1, BRCA2, XPA
15response to organic substanceGO:001003310.0CCND1, XRCC1, XRCC3
16response to X-rayGO:00101659.9BRCA2, CCND1, TP53
17negative regulation of histone H3-K9 methylationGO:00515739.9BRCA1, DNMT1, DNMT3B
18positive regulation of histone H3-K4 methylationGO:00515719.9BRCA1, DNMT1, DNMT3B
19response to auditory stimulusGO:00109969.9XPA, XPC
20UV-damage excision repairGO:00709149.8XPA, XPC
21protein sumoylationGO:00169259.8BRCA1, TP53, XPC
22base-excision repairGO:00062849.8TP53, XPA, XRCC1
23response to caffeineGO:00310009.8DNMT1, DNMT3B, IGF1
24response to activityGO:00148239.7DNMT1, DNMT3B, IGF1
25response to ionizing radiationGO:00102129.6BRCA1, DNMT1, DNMT3B, XRCC3
26regulation of mitotic cell cycle phase transitionGO:19019909.5ERCC2, XPC
27positive regulation of gene expressionGO:00106289.5BRCA1, DNMT1, DNMT3B, TP53
28Ras protein signal transductionGO:00072659.4DNMT1, IGF1, TP53
29transcription-coupled nucleotide-excision repairGO:00062839.4ERCC2, XPA, XRCC1
30multicellular organism growthGO:00352649.3BRCA2, ERCC2, XPA
31nucleotide-excision repair, DNA damage recognitionGO:00007159.3RAD23B, XPA, XPC
32response to estradiolGO:00323559.0BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
33response to toxic substanceGO:00096368.9BLMH, DNMT1, DNMT3B, XPA
34positive regulation of transcription, DNA-templatedGO:00458938.8BRCA1, BRCA2, ERCC2, IGF1, TP53
35response to drugGO:00424938.6BLMH, CCND1, DNMT3B, XPC, XRCC1
36DNA repairGO:00062818.5ERCC2, XPA, XPC, XRCC1, XRCC3
37nucleotide-excision repair, preincision complex assemblyGO:00062948.5ERCC2, RAD23B, XPA, XPC
38global genome nucleotide-excision repairGO:00709118.5ERCC2, RAD23B, XPA, XPC
39nucleotide-excision repair, DNA duplex unwindingGO:00007178.5ERCC2, RAD23B, XPA, XPC
40response to hypoxiaGO:00016668.4DNMT3B, ERCC2, IGF1, XRCC1
41cellular response to DNA damage stimulusGO:00069747.9BRCA1, BRCA2, CCND1, RAD23B, TP53, XPC
42nucleotide-excision repairGO:00062897.8BRCA2, ERCC2, RAD23B, TP53, XPA, XPC

Molecular functions related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1DNA-methyltransferase activityGO:000900810.3DNMT1, DNMT3B
2unmethylated CpG bindingGO:004532210.3DNMT1, DNMT3B
3DNA (cytosine-5-)-methyltransferase activity, acting on CpG substratesGO:005171810.3DNMT1, DNMT3B
4DNA (cytosine-5-)-methyltransferase activityGO:000388610.2DNMT1, DNMT3B
5double-stranded DNA bindingGO:000369010.0DNMT1, TP53, XRCC3
6histone deacetylase bindingGO:00428269.8CCND1, DNMT1, DNMT3B
7enzyme bindingGO:00198999.4BRCA1, CCND1, GSTM1, TP53, XRCC1
8single-stranded DNA bindingGO:00036979.3BRCA2, RAD23B, XPC, XRCC3
9damaged DNA bindingGO:00036848.5BRCA1, RAD23B, TP53, XPA, XPC, XRCC1
10protein bindingGO:00055154.5BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Sources for Mutagen Sensitivity

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet