MCID: MTG002
MIFTS: 24

Mutagen Sensitivity malady

Rare diseases category

Summaries for Mutagen Sensitivity

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34MalaCards
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MalaCards: Mutagen Sensitivity is related to lung cancer and breast cancer. An important gene associated with Mutagen Sensitivity is BLMH (bleomycin hydrolase). Affiliated tissues include lung, breast and skin.

Aliases & Classifications for Mutagen Sensitivity

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

mutagen sensitivity 44


Related Diseases for Mutagen Sensitivity

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18GeneCards, 19GeneDecks
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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer10.6
2breast cancer10.5
3nasopharyngitis10.2
4melanoma10.2
5oral cancer10.2
6sporadic breast cancer10.1
7barrett's esophagus10.1
8ataxia telangiectasia10.1
9colon cancer10.1
10colorectal cancer10.1
11endometriosis10.1
12hepatocellular carcinoma10.1
13sarcoma10.1
14soft tissue sarcoma10.1
15squamous cell carcinoma of the head and neck10.1
16cutaneous malignant melanoma10.1
17ataxia10.1
18cytomegalovirus infection10.1

Graphical network of diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Symptoms for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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34MalaCards
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MalaCards organs/tissues related to Mutagen Sensitivity:

34
Lung, Breast, Skin, Testes, Colon

Animal Models for Mutagen Sensitivity or affiliated genes

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Publications for Mutagen Sensitivity

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53PubMed
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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Bleomycin-induced mutagen sensitivity, passive smoking, and risk of breast cancer in Chinese women: a case-control study. (23371556)
2013
2
Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. (22218884)
2012
3
Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches. (21595606)
2011
4
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. (21164199)
2011
5
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
6
Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer. (20400363)
2010
7
Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study. (20110285)
2010
8
Chromosomal alterations and mutagen sensitivity in human mucosal cells of the oropharynx and lymphocytes caused by BPDE. (19996129)
2009
9
Mutagen sensitivity: a genetic predisposition factor for cancer. (17440053)
2007
10
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)
2007
11
Mutagen sensitivity has high heritability: evidence from a twin study. (16778168)
2006
12
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. (17035402)
2006
13
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay. (16537698)
2006
14
Reliability of mutagen sensitivity assay: an inter-laboratory comparison. (16870697)
2006
15
High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy. (15837739)
2005
16
Mutagen sensitivity of patients with cancer at different sites of the head and neck. (16105906)
2005
17
Differential mutagen sensitivity of peripheral blood lymphocytes from smokers and nonsmokers: effect of human cytomegalovirus infection. (15065204)
2004
18
Inter-rater agreement on chromosome 5 breakage in FISH-based mutagen sensitivity assays (MSAs). (15279836)
2004
19
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study. (14757193)
2004
20
Chromosomal mutagen sensitivity associated with mutations in BRCA genes. (15162060)
2004
21
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. (12611459)
2003
22
Mutagen sensitivity as a susceptibility marker for endometriosis. (14507820)
2003
23
Construction of green fluorescent protein reporter genes for genotoxicity test (SOS/umu-test) and improvement of mutagen-sensitivity. (16233101)
2001
24
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10984281)
2000
25
Mutagen sensitivity in patients with familial and non-familial urothelial cell carcinoma. (11054683)
2000
26
Mutagen sensitivity as a biomarker for second primary tumors after head and neck squamous cell carcinoma. (10919742)
2000
27
Family history of cancer, mutagen sensitivity, and increased risk of head and neck cancer. (10656614)
1999
28
Genetics of smoking-related cancer and mutagen sensitivity. (10393708)
1999
29
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. (9676854)
1998
30
Increased mutagen sensitivity in patients with head and neck cancer is less pronounced in patients with nasopharyngeal carcinoma. (9604986)
1998
31
A statistical analysis of the reliability and classification error in application of the mutagen sensitivity assay. (8833619)
1996
32
Mutagen sensitivity as a predisposing factor in familial oral cancer. (8797865)
1996
33
Mutagen sensitivity: enhanced risk assessment of squamous cell carcinoma. (9039218)
1996
34
Mutagen sensitivity and risk of gliomas: a case-control analysis. (8603389)
1996
35
Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. (7541679)
1995
36
A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk. (8547823)
1995
37
Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck. (7539412)
1995
38
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. (7537995)
1995
39
Lung cancer, smoking patterns, and mutagen sensitivity in Mexican-Americans. (8562219)
1995
40
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. (7907981)
1994
41
Mitotic catastrophe is the mechanism of lethality for mutations that confer mutagen sensitivity in Aspergillus nidulans. (7506362)
1994
42
Mutagen sensitivity as a marker of cancer risk. (7526974)
1994
43
Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. (7682127)
1993
44
Increased mutagen sensitivity in human cultured fibroblasts with constitutively high micronucleus levels. (1551087)
1992
45
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. (1700135)
1990
46
Epistasis, photoreactivation and mutagen sensitivity of DNA repair mutants upr-1 and mus-26 in Neurospora crassa. (2528064)
1989
47
Mutagen sensitivity and mutability in lentil. (24247709)
1986
48
Biochemical genetics of Neurospora nuclease II: Mutagen sensitivity and other characteristics of the nuclease mutants. (6309614)
1983
49
Mutagen sensitivity of wild type and recombination deficient c(3)G strains of Drosophila melanogaster. (121955)
1978
50
Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa. (188973)
1977

Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutagen Sensitivity

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Pathways for genes affiliated with Mutagen Sensitivity

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Compounds for genes affiliated with Mutagen Sensitivity

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GO Terms for genes affiliated with Mutagen Sensitivity

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Products for genes affiliated with Mutagen Sensitivity

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Sources for Mutagen Sensitivity

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet