Mutagen Sensitivity malady

Summaries for Mutagen Sensitivity

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MalaCards: Mutagen Sensitivity is related to lung cancer and breast cancer. An important gene associated with Mutagen Sensitivity is XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3), and among its related pathways are DNA Damage Recognition in GG-NER and Fluoropyrimidine Pathway, Pharmacodynamics. The compounds manganese superoxide and methylchloride have been mentioned in the context of this disorder. Related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Mutagen Sensitivity

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42NIH Rare Diseases
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Aliases & Descriptions:

mutagen sensitivity 42

Related Diseases for Mutagen Sensitivity

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17GeneCards, 18GeneDecks
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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.8GSTM1, ERCC2, DNMT3B, XRCC3, XRCC1
2breast cancer30.6DNMT3B, DNMT1, TOPBP1, NAT2, ERCC2, GSTT1
3squamous cell carcinoma30.6GSTT1, XPA, FANCG, XPC, DNMT3B, XRCC3
4melanoma30.3XRCC3, XPC, DNMT1, XRCC1, ERCC2, GSTT1
6endometriosis30.1GSTT1, GSTM1, NAT2
7ataxia telangiectasia30.0BLM, TOPBP1, XRCC1, DNMT1, XRCC3, XPA
8hepatocellular carcinoma30.0XPC, DNMT3B, GSTM1, NAT2, DNMT1, GSTT1
9colon cancer30.0DNMT3B, DNMT1, NAT2, GSTM1, XRCC1, GSTT1
10colorectal cancer30.0XRCC1, GSTM1, ERCC2, NAT2, GSTT1, DNMT1
12sporadic breast cancer10.1
13barrett's esophagus10.1
16multiple sclerosis10.0GSTM1
17malignant glioma10.0DNMT3B
18myeloid leukemia10.0DNMT1
19malignant mesothelioma10.0NAT2
20spina bifida10.0NAT2
21primary open angle glaucoma10.0GSTM1
22lupus erythematosus10.0NAT2
23leukoplakia10.0GSTM1, GSTT1
24oral cancer10.0GSTT1, GSTM1
25laryngeal benign neoplasm10.0GSTT1, NAT2
26motor neuron disease10.0GSTT1
27brain cancer10.0GSTT1, GSTM1
28bloom syndrome10.0MUS81, BLM
29cataract10.0GSTT1, NAT2
30testicular cancer10.0ERCC2, DNMT1
31cervical cancer10.0XRCC1, GSTT1, GSTM1
32thyroid cancer10.0GSTM1, GSTT1
33deficiency anemia10.0FANCG, DNMT1, GSTM1
34photosensitive trichothiodystrophy10.0XPA, ERCC5, ERCC2
35familial adenomatous polyposis10.0NAT2, DNMT1
36immunodeficiency, centromere instability and facial anomalies syndrome10.0DNMT1, DNMT3B
37skin benign neoplasm10.0ERCC2, XPA, XPC
38astrocytoma10.0GSTT1, XPC, ERCC2
39acute lymphoblastic leukemia, childhood10.0XRCC1, GSTM1, GSTT1
40hepatitis10.0GSTT1, NAT2, REV3L
41open-angle glaucoma10.0GSTM1, GSTT1
42laryngeal squamous cell carcinoma10.0GSTT1, GSTM1, NAT2
43pancreatic cancer10.0XRCC1, DNMT1, FANCG, NAT2
44bladder carcinoma10.0GSTT1, NAT2, GSTM1
45acute leukemia10.0DNMT3B, DNMT1, GSTM1, GSTT1
46lung adenocarcinoma10.0GSTT1, GSTM1, XPA, XRCC1
47squamous cell carcinoma of the head and neck10.0XRCC1, DNMT3B, GSTM1, FANCG, GSTT1
48fanconi's anemia10.0MUS81, ERCC2, BLM, FANCG
49lung benign neoplasm10.0XRCC1, XPC, DNMT1, ERCC2
50liver cirrhosis10.0NAT2

Graphical network of the top 20 diseases related to Mutagen Sensitivity:

Diseases related to mutagen sensitivity

Clinical Features for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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Animal Models for Mutagen Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Mutagen Sensitivity:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8XPC, BLM, DNMT1
2MP:00020069.7BLM, DNMT3B, DNMT1, REV3L
3MP:00036319.6REV3L, DNMT1, TOPBP1
4MP:00053899.4FANCG, DNMT3B, DNMT1, NAT2, RAD23B
5MP:00053809.2TOPBP1, BLM, REV3L, RAD23B
6MP:00053978.5POLQ, BLM, DNMT3B, DNMT1, REV3L, ERCC5
7MP:00053788.2BLM, XPC, XPA, XRCC1, BLMH, DNMT3B
9MP:00053767.8XRCC1, XPA, XPC, BLMH, DNMT1, MUS81
10MP:00107687.7BLM, TOPBP1, XPC, XPA, XRCC1, BLMH
11MP:00053847.5GSTM1, XRCC1, FANCG, XPA, XPC, TOPBP1

Publications for Mutagen Sensitivity

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Genetic Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Mutagen Sensitivity

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Pathways for genes affiliated with Mutagen Sensitivity

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Mutagen Sensitivity

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1manganese superoxide4410.5GSTT1
2methylchloride4410.4GSTM1, GSTT1
3n-(2-hydroxyethyl)valine4410.4GSTM1, GSTT1
4trans,trans-muconic acid4410.4GSTM1, GSTT1
5s-phenylmercapturic acid4410.4GSTT1, GSTM1
6hema4410.4GSTT1, GSTM1
7polyvinyl chloride4410.4XRCC1, GSTT1
8styrene oxide4410.4GSTT1, GSTM1
92-naphthol4410.4GSTM1, GSTT1
10ethylene oxide4410.4GSTM1, GSTT1
11butadiene monoxide4410.4GSTM1, GSTT1
121,3-butadiene4410.3GSTT1, GSTM1
13zebularine4410.3DNMT3B, DNMT1
14cumene hydroperoxide4410.3GSTM1, GSTT1
15vinylchloride4410.3XRCC1, GSTM1, GSTT1
168-oxoguanine4410.3XRCC1, GSTM1, GSTT1
17platinum44 4911.3XRCC1, GSTT1, ERCC2
18drugs for treatment of tuberculosis4910.2GSTT1, NAT2, GSTM1
19arylamine4410.2NAT2, GSTT1, GSTM1
201-hydroxypyrene4410.2GSTT1, NAT2, GSTM1
213-deazaneplanocin a hydrochloride5910.2DNMT1, DNMT3B
22styrene4410.2NAT2, GSTM1, GSTT1
23trichloroethylene4410.2GSTT1, NAT2, GSTM1
24benzidine4410.2GSTM1, NAT2, GSTT1
25isoniazid49 44 1112.2GSTM1, NAT2, GSTT1
26sgc 09465910.2DNMT1, DNMT3B
27aflatoxin b144 2411.2GSTT1, GSTM1, NAT2
28rsai4410.2NAT2, GSTM1, GSTT1
29bix 012945910.2DNMT1, DNMT3B
30p0034410.1XRCC3, XRCC1, GSTM1, GSTT1
31unc 06385910.1DNMT1, DNMT3B
322-acetylaminofluorene4410.1XPC, XPA
33unc 06465910.1DNMT1, DNMT3B
34gsts4410.1GSTM1, GSTT1, XRCC1, NAT2
35betacarotene4410.1NAT2, GSTM1, XRCC1
36epoxide4410.1XRCC1, GSTT1, NAT2, GSTM1
37ecteinascidin 7434410.0ERCC5, ERCC2
38cyclophosphamide44 49 1112.0XRCC1, ERCC2, GSTT1, GSTM1
39hydrocarbons4410.0NAT2, ERCC2, GSTM1, GSTT1
40benzene449.9GSTT1, GSTM1, NAT2, XRCC1, XRCC3
41diepoxybutane449.9NAT2, XRCC1, GSTM1, GSTT1, FANCG
42oxaliplatin44 49 1111.9ERCC2, XPA, GSTM1, XRCC1, GSTT1
43cotinine44 2410.8ERCC2, GSTM1, XRCC1, NAT2, GSTT1
44platinum compounds499.8XRCC1, ERCC2
45cadmium44 2410.7XRCC1, XPA, DNMT1
46benzo(a)pyrene449.7GSTT1, GSTM1, NAT2, XPC, XPA, XRCC1
47mspi449.5GSTT1, GSTM1, ERCC2, NAT2, DNMT1, XRCC1
48oligonucleotide449.3XRCC1, XPA, GSTT1, DNMT3B, DNMT1, ERCC5
49folate449.2DNMT1, DNMT3B, XRCC3, GSTT1, GSTM1, ERCC2
50cisplatin44 49 59 1111.7ERCC2, XRCC3, FANCG, XPA, XPC, DNMT1

GO Terms for genes affiliated with Mutagen Sensitivity

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16Gene Ontology
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Cellular components related to Mutagen Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.1XPC, RAD23B
2male germ cell nucleusGO:00167310.0BLM, TOPBP1
3holo TFIIH complexGO:0056759.9ERCC2, ERCC5
4replication forkGO:0056579.6DNMT1, BLM
5nucleoplasmGO:0056548.9ERCC2, XRCC1, FANCG, XPA, XPC, POLQ
6nucleusGO:0056347.7TOPBP1, XPC, XPA, XRCC3, XRCC1, HELQ

Biological processes related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.3RAD23B, XPC
2regulation of mitotic cell cycle phase transitionGO:190199010.2ERCC2, XPC
3negative regulation of histone H3-K9 methylationGO:05157310.1DNMT1, DNMT3B
4positive regulation of histone H3-K4 methylationGO:05157110.0DNMT1, DNMT3B
5DNA methylationGO:00630610.0DNMT1, DNMT3B
6UV protectionGO:0096509.9ERCC2, ERCC5
7DNA recombinationGO:0063109.8XRCC3, BLM, MUS81
8nucleotide-excision repair, DNA damage removalGO:0007189.7XPA, XPC, RAD23B, ERCC5, ERCC2
9nucleotide-excision repairGO:0062899.7XPA, XPC, RAD23B, ERCC5, ERCC2
10response to drugGO:0424939.5XRCC1, XPC, BLMH, GSTT1
11DNA repairGO:0062818.0ERCC2, XRCC1, XRCC3, FANCG, XPA, XPC

Molecular functions related to Mutagen Sensitivity according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA-methyltransferase activityGO:00900810.0DNMT3B, DNMT1
2bubble DNA bindingGO:0004059.9XPC, BLM, ERCC5
3DNA (cytosine-5-)-methyltransferase activityGO:0038869.9DNMT1, DNMT3B
4single-stranded DNA bindingGO:0036979.7ERCC5, RAD23B, BLM, XPC
5damaged DNA bindingGO:0036849.5RAD23B, POLQ, XPC, XPA, FANCG, XRCC1
6ATP-dependent helicase activityGO:0080269.4BLM, POLQ, HELQ
7DNA bindingGO:0036778.8TOPBP1, DNMT3B, DNMT1, MUS81, REV3L, ERCC2
8protein bindingGO:0055157.3XRCC1, XRCC3, FANCG, XPA, XPC, TOPBP1

Products for genes affiliated with Mutagen Sensitivity

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Sources for Mutagen Sensitivity

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet