MCID: MTG002
MIFTS: 37

Mutagen Sensitivity malady

Category: Rare diseases

Aliases & Classifications for Mutagen Sensitivity

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Aliases & Descriptions for Mutagen Sensitivity:

Name: Mutagen Sensitivity 45

Classifications:



Summaries for Mutagen Sensitivity

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MalaCards based summary: Mutagen Sensitivity is related to breast cancer and lung cancer. An important gene associated with Mutagen Sensitivity is BRCA1 (Breast Cancer 1), and among its related pathways are Resolution of D-Loop Structures and BRCA1 Pathway. Affiliated tissues include breast, lung and prostate, and related mouse phenotypes are limbs/digits/tail and pigmentation.

Related Diseases for Mutagen Sensitivity

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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer27.3BRCA1, BRCA2, CCND1, DNMT3B, IGF1, NAT2
2lung cancer27.0CCND1, DNMT1, DNMT3B, ERCC2, GSTM1, GSTT1
3colorectal cancer25.8BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, GSTM1
4congenital pulmonary veins atresia or stenosis10.8BRCA1, BRCA2
5bronchiolitis obliterans10.7BRCA1, BRCA2
6autoimmune polyendocrine syndrome type 110.7BRCA1, BRCA2
7autoimmune disease of urogenital tract10.7BRCA1, BRCA2
8malignant testicular leydig cell tumor10.7BRCA1, BRCA2
9breast cancer, childhood10.6BRCA1, BRCA2
10brca2 hereditary breast and ovarian cancer syndrome10.6BRCA1, BRCA2
11pancreatic cancer 410.6BRCA1, BRCA2
12mastitis10.5BRCA1, BRCA2
13vulvar alveolar soft part sarcoma10.5BRCA1, BRCA2
14pancreatic serous cystadenocarcinoma10.5BRCA1, BRCA2, TP53
15cystadenoma10.5BRCA1, BRCA2, TP53
16endometrial mucinous adenocarcinoma10.5BRCA1, BRCA2, TP53
17oral lichen planus10.5GSTM1, NAT2, XRCC1
18peritoneal cystic mesothelioma10.5BRCA1, BRCA2, TP53
19fallopian tube leiomyosarcoma10.5BRCA1, BRCA2, TP53
20uterine carcinosarcoma10.5BRCA1, BRCA2, TP53
21tetrasomy 2110.5BRCA1, BRCA2, TP53
22vascular dementia10.4BRCA1, BRCA2, TP53
23dyskinetic cerebral palsy10.4BRCA2, TP53, XRCC1
24retroperitoneal lymphoma10.4GSTM1, GSTT1, TP53
25ovary epithelial cancer10.4BRCA1, BRCA2, TP53
26filamentary keratitis10.4GSTM1, GSTT1, NAT2
27partial of retinal vein occlusion10.4BRCA1, BRCA2
28ovarian wilms' cancer10.4BRCA1, BRCA2, TP53
29spondyloepimetaphyseal dysplasia, sponastrime type10.4BRCA1, BRCA2, TP53
30common variable immunodeficiency10.4TP53, XRCC1, XRCC3
31ectodermal dysplasia10.4GSTM1, GSTT1, NAT2
32setariasis10.4BRCA1, BRCA2
333-methylglutaconic aciduria, type i10.3TP53, XPA, XPC
34acute monocytic leukemia10.3GSTM1, GSTT1, TP53
35microglandular adenosis10.3CCND1, TP53, XRCC1
36exposure keratitis10.2BRCA1, TP53
37choroid plexus papilloma10.2BRCA1, BRCA2, TP53, XPC
38integumentary system benign neoplasm10.2CCND1, GSTM1, TP53
39lipoadenoma10.1IGF1, TP53
40renal pelvis squamous cell carcinoma10.0CCND1, TP53
41glottis neoplasm10.0GSTM1, GSTT1, NAT2, XRCC1, XRCC3
42internal auditory canal lipoma10.0BRCA1, BRCA2, CCND1, TP53
43lymphatic system cancer10.0BRCA1, BRCA2, CCND1, TP53
44eye carcinoma in situ10.0BRCA1, BRCA2, CCND1, TP53
45mucolipidosis iv10.0DNMT1, DNMT3B
46estrogen-receptor positive breast cancer10.0BRCA1, BRCA2, CCND1, TP53
47melanoma10.0
48tracheal lymphoma10.0BRCA1, BRCA2, CCND1, TP53
49oral leukoplakia10.0CCND1, GSTM1, GSTT1, TP53
50juxtacortical chondroma10.0CCND1, GSTM1, GSTT1, TP53

Graphical network of the top 20 diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Symptoms for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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Interventional clinical trials:

idNameStatusNCT IDPhase
1DNA Repair, p53 and Apoptosis Phenotypes in Lung CancerRecruitingNCT00339859
2Genetic Susceptibility to Bladder CancerRecruitingNCT00848289

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Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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MalaCards organs/tissues related to Mutagen Sensitivity:

33
Breast, Lung, Prostate, B cells, Endothelial, Monocytes, Ovary

Animal Models for Mutagen Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Mutagen Sensitivity:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9BLMH, BRCA1, BRCA2, IGF1, TP53, XPA
2MP:00011868.8BRCA1, DNMT1, ERCC2, TP53, XPA
3MP:00053808.5BRCA1, BRCA2, DNMT1, DNMT3B, RAD23B, TP53
4MP:00053758.1BRCA1, ERCC2, IGF1, RAD23B, TP53, XPA
5MP:00028737.9BRCA1, BRCA2, CCND1, DNMT1, IGF1, RAD23B
6MP:00053917.6CCND1, DNMT3B, ERCC2, RAD23B, TP53, XPA
7MP:00053796.9BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
8MP:00053906.7BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
9MP:00053866.7BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
10MP:00053976.4BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
11MP:00107716.4BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
12MP:00020066.3BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
13MP:00036316.2BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
14MP:00053766.0BLMH, BRCA1, BRCA2, CCND1, ERCC2, IGF1
15MP:00053896.0BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
16MP:00053875.8BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
17MP:00053845.8BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
18MP:00053785.3BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
19MP:00107685.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Publications for Mutagen Sensitivity

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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis. (24977319)
2014
2
Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk. (24623229)
2014
3
Bleomycin-induced mutagen sensitivity, passive smoking, and risk of breast cancer in Chinese women: a case-control study. (23371556)
2013
4
Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. (22218884)
2012
5
Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches. (21595606)
2011
6
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. (21164199)
2011
7
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
8
Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer. (20400363)
2010
9
Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study. (20110285)
2010
10
Chromosomal alterations and mutagen sensitivity in human mucosal cells of the oropharynx and lymphocytes caused by BPDE. (19996129)
2009
11
Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. (18499700)
2008
12
Mutagen sensitivity: a genetic predisposition factor for cancer. (17440053)
2007
13
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)
2007
14
Mutagen sensitivity has high heritability: evidence from a twin study. (16778168)
2006
15
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. (17035402)
2006
16
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay. (16537698)
2006
17
High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy. (15837739)
2005
18
Mutagen sensitivity of patients with cancer at different sites of the head and neck. (16105906)
2005
19
Differential mutagen sensitivity of peripheral blood lymphocytes from smokers and nonsmokers: effect of human cytomegalovirus infection. (15065204)
2004
20
Inter-rater agreement on chromosome 5 breakage in FISH-based mutagen sensitivity assays (MSAs). (15279836)
2004
21
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study. (14757193)
2004
22
Chromosomal mutagen sensitivity associated with mutations in BRCA genes. (15162060)
2004
23
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. (12611459)
2003
24
Mutagen sensitivity as a susceptibility marker for endometriosis. (14507820)
2003
25
Construction of green fluorescent protein reporter genes for genotoxicity test (SOS/umu-test) and improvement of mutagen-sensitivity. (16233101)
2001
26
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10984281)
2000
27
Mutagen sensitivity in patients with familial and non-familial urothelial cell carcinoma. (11054683)
2000
28
Mutagen sensitivity as a biomarker for second primary tumors after head and neck squamous cell carcinoma. (10919742)
2000
29
Family history of cancer, mutagen sensitivity, and increased risk of head and neck cancer. (10656614)
1999
30
Genetics of smoking-related cancer and mutagen sensitivity. (10393708)
1999
31
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. (9676854)
1998
32
Increased mutagen sensitivity in patients with head and neck cancer is less pronounced in patients with nasopharyngeal carcinoma. (9604986)
1998
33
A statistical analysis of the reliability and classification error in application of the mutagen sensitivity assay. (8833619)
1996
34
Mutagen sensitivity as a predisposing factor in familial oral cancer. (8797865)
1996
35
Mutagen sensitivity: enhanced risk assessment of squamous cell carcinoma. (9039218)
1996
36
Mutagen sensitivity and risk of gliomas: a case-control analysis. (8603389)
1996
37
Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. (7541679)
1995
38
A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk. (8547823)
1995
39
Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck. (7539412)
1995
40
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. (7537995)
1995
41
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. (7907981)
1994
42
Mitotic catastrophe is the mechanism of lethality for mutations that confer mutagen sensitivity in Aspergillus nidulans. (7506362)
1994
43
Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. (7682127)
1993
44
Increased mutagen sensitivity in human cultured fibroblasts with constitutively high micronucleus levels. (1551087)
1992
45
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. (1700135)
1990
46
Epistasis, photoreactivation and mutagen sensitivity of DNA repair mutants upr-1 and mus-26 in Neurospora crassa. (2528064)
1989
47
Mutagen sensitivity and mutability in lentil. (24247709)
1986
48
Biochemical genetics of Neurospora nuclease II: Mutagen sensitivity and other characteristics of the nuclease mutants. (6309614)
1983
49
Mutagen sensitivity of wild type and recombination deficient c(3)G strains of Drosophila melanogaster. (121955)
1978
50

Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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Search GEO for disease gene expression data for Mutagen Sensitivity.

Pathways for genes affiliated with Mutagen Sensitivity

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Pathways related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA1, BRCA2, XRCC3
2
Show member pathways
9.7BRCA1, BRCA2, TP53
39.5BRCA2, CCND1, XRCC1
49.4BRCA1, CCND1, TP53
59.4BRCA1, CCND1, TP53
69.4BRCA1, BRCA2, TP53, XPC
79.2CCND1, DNMT1, TP53
89.0CCND1, IGF1, TP53
98.9BRCA1, BRCA2, CCND1, TP53, XRCC3
108.8ERCC2, GSTM1, GSTT1, XPA
11
Show member pathways
8.8BRCA1, CCND1, IGF1, TP53
128.7ERCC2, TP53, XPA, XPC
13
Show member pathways
8.6ERCC2, RAD23B, XPA, XPC
148.5BRCA1, BRCA2, CCND1, IGF1, TP53
15
Show member pathways
8.5BRCA1, BRCA2, CCND1, IGF1, TP53
168.4BRCA1, CCND1, DNMT1, DNMT3B, TP53
17
Show member pathways
8.4ERCC2, RAD23B, XPA, XPC, XRCC1
18
Show member pathways
7.3BRCA1, BRCA2, ERCC2, RAD23B, TP53, XPA
19
Show member pathways
6.4BRCA1, BRCA2, CCND1, ERCC2, IGF1, RAD23B

GO Terms for genes affiliated with Mutagen Sensitivity

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Biological processes related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1DNA synthesis involved in DNA repairGO:000073110.4BRCA1, BRCA2
2chordate embryonic developmentGO:004300910.4BRCA1, BRCA2
3response to auditory stimulusGO:001099610.3XPA, XPC
4response to gamma radiationGO:001033210.3BRCA2, TP53
5intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.3BRCA2, TP53
6double-strand break repair via homologous recombinationGO:000072410.2BRCA1, BRCA2, XRCC1
7UV-damage excision repairGO:007091410.2XPA, XPC
8double-strand break repair via synthesis-dependent strand annealingGO:004500310.2BRCA1, BRCA2, XRCC3
9DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1BRCA1, BRCA2, TP53
10intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.1BRCA1, BRCA2, XPA
11nucleotide-excision repair, DNA damage recognitionGO:000071510.0RAD23B, XPC
12protein sumoylationGO:001692510.0BRCA1, TP53, XPC
13response to ionizing radiationGO:001021210.0BRCA1, DNMT1, XRCC3
14nucleotide-excision repair, preincision complex stabilizationGO:00062939.8ERCC2, XPA
15response to vitamin AGO:00331899.8DNMT1, DNMT3B
16nucleotide-excision repair, preincision complex assemblyGO:00062949.8RAD23B, XPA, XPC
17transcription-coupled nucleotide-excision repairGO:00062839.6ERCC2, XPA, XRCC1
18positive regulation of DNA bindingGO:00433889.5ERCC2, IGF1
19negative regulation of histone H3-K9 methylationGO:00515739.5DNMT1, DNMT3B
20global genome nucleotide-excision repairGO:00709119.3ERCC2, XPA, XRCC1
21negative regulation of transcription, DNA-templatedGO:00458929.3BRCA1, DNMT1, DNMT3B, TP53
22DNA methylation on cytosine within a CG sequenceGO:00104249.2DNMT1, DNMT3B
23positive regulation of histone H3-K4 methylationGO:00515719.2BRCA1, DNMT1, DNMT3B
24response to drugGO:00424939.2DNMT1, DNMT3B, XPC, XRCC1
25response to organic substanceGO:00100339.0DNMT1, IGF1, XRCC1, XRCC3
26DNA repairGO:00062818.9BRCA1, ERCC2, XPA, XPC
27response to activityGO:00148238.9DNMT1, DNMT3B, IGF1
28cellular response to DNA damage stimulusGO:00069748.4BRCA1, BRCA2, CCND1, RAD23B, TP53, XPC

Molecular functions related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA-methyltransferase activityGO:00090089.5DNMT1, DNMT3B
2unmethylated CpG bindingGO:00453229.5DNMT1, DNMT3B
3single-stranded DNA bindingGO:00036979.1BRCA2, RAD23B, XPC, XRCC3
4DNA-dependent ATPase activityGO:00080949.1ERCC2, XRCC3

Sources for Mutagen Sensitivity

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet