MCID: MTG002
MIFTS: 36

Mutagen Sensitivity malady

Category: Rare diseases

Aliases & Classifications for Mutagen Sensitivity

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Aliases & Descriptions for Mutagen Sensitivity:

Name: Mutagen Sensitivity 47

Classifications:



Summaries for Mutagen Sensitivity

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MalaCards based summary: Mutagen Sensitivity is related to nasopharyngeal carcinoma and lung cancer. An important gene associated with Mutagen Sensitivity is GSTT1 (Glutathione S-Transferase Theta 1), and among its related pathways are DNA Damage Induced 14-3-3Sigma Signaling and BRCA1 Pathway. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are pigmentation and embryo.

Related Diseases for Mutagen Sensitivity

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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngeal carcinoma29.6BRCA1, BRCA2, TP53, XPC
2lung cancer28.3CCND1, DNMT1, ERCC2, GSTM1, GSTT1, TP53
3breast cancer26.9BRCA1, BRCA2, CCND1, DNMT3B, IGF1, NAT2
4colorectal cancer25.5BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, GSTM1
5congenital pulmonary veins atresia or stenosis10.6BRCA1, BRCA2
6bronchopulmonary dysplasia10.5BRCA1, BRCA2
7cutaneous lupus erythematosus10.5BRCA1, BRCA2
8autoimmune disease of blood10.5BRCA1, BRCA2
9selective ige deficiency disease10.5BRCA1, BRCA2
10familial breast cancer10.5BRCA1, BRCA2
11breast cancer, childhood10.4BRCA1, BRCA2
12lethal congenital contracture syndrome 710.4BRCA1, BRCA2
13emery-dreifuss muscular dystrophy, dominant type10.4GSTM1, GSTT1, NAT2
14cervical serous adenocarcinoma10.3BRCA1, BRCA2, TP53
15ovarian brenner tumor10.3BRCA1, BRCA2, TP53
16rectum mucinous adenocarcinoma10.3BRCA1, BRCA2, TP53
17papillary adenofibroma10.3BRCA1, BRCA2, TP53
18diplegia of upper limb10.3GSTM1, GSTT1, NAT2
19leiomyosarcoma10.3BRCA1, BRCA2, TP53
20distal monosomy 9p10.3BRCA1, BRCA2, TP53
21adrenal cortical carcinoma10.3GSTM1, TP53, XRCC1
22dental caries10.3BRCA1, BRCA2, TP53
23visual cortex disease10.3BRCA1, BRCA2, TP53
24mixed cerebral palsy10.3BRCA2, TP53, XRCC1
25milker's nodule10.3BRCA1, BRCA2, TP53
26acute myocardial infarction10.3GSTM1, GSTT1, TP53
27fat necrosis of breast10.3BRCA1, BRCA2
28ovarian wilms' cancer10.3BRCA1, BRCA2, TP53
29lung carcinoma in situ10.3BRCA1, BRCA2, TP53
30oral pharyngeal disorders10.3GSTM1, GSTT1, TP53, XRCC1
31levic stefanovic nikolic syndrome10.3GSTM1, GSTT1, TP53, XRCC1
32cerebrooculofacioskeletal syndrome 210.3ERCC2, XPC, XRCC1
33stroma-dominant and stroma-poor composite ganglioneuroblastoma10.3ERCC2, TP53, XRCC1
34tumor predisposition syndrome10.2BRCA1, BRCA2, TP53
35xeroderma pigmentosum, group c10.2RAD23B, XPC
36apocrine adenosis of breast10.2CCND1, XRCC1
37fallopian tube germ cell cancer10.2BRCA1, BRCA2
383-methylglutaconic aciduria, type i10.2XPA, XPC
39amyloid tumor10.1BRCA1, BRCA2, CCND1
40asthenopia10.0ERCC2, TP53, XPA
41bullous keratopathy10.0ERCC2, TP53, XPA
42cholesteatoma of external ear10.0BRCA1, TP53
43chondroma10.0CCND1, GSTM1, GSTT1, TP53
44heavy chain disease10.0ERCC2, TP53, XPA
453-methylglutaconic aciduria, type iii10.0ERCC2, RAD23B, XPA
46pineal region meningioma10.0BRCA1, BRCA2, GSTM1, TP53, XRCC1
47short-rib thoracic dysplasia 3 with or without polydactyly10.0BRCA1, BRCA2, TP53
48bursitis10.0ERCC2, XPA, XPC
49cervical cancer, somatic10.0CCND1, GSTM1, GSTT1, TP53
50ductal carcinoma in situ9.9BRCA1, BRCA2, CCND1, TP53

Graphical network of the top 20 diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Symptoms for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Susceptibility to Bladder CancerUnknown statusNCT00848289
2DNA Repair, p53 and Apoptosis Phenotypes in Lung CancerRecruitingNCT00339859

Search NIH Clinical Center for Mutagen Sensitivity

Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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MalaCards organs/tissues related to Mutagen Sensitivity:

35
Lung, Testes, Skin, Colon

Animal Models for Mutagen Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Mutagen Sensitivity:

40 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9BRCA1, DNMT1, ERCC2, TP53, XPA
2MP:00053808.4BRCA1, BRCA2, DNMT1, DNMT3B, RAD23B, TP53
3MP:00053718.4BLMH, BRCA1, BRCA2, IGF1, TP53, XPA
4MP:00053757.9BRCA1, ERCC2, IGF1, RAD23B, TP53, XPA
5MP:00053917.7CCND1, DNMT3B, ERCC2, RAD23B, TP53, XPA
6MP:00028737.5BRCA1, BRCA2, CCND1, DNMT1, IGF1, RAD23B
7MP:00053907.0BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
8MP:00053796.8BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
9MP:00053866.6BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
10MP:00107716.3BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
11MP:00053976.2BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
12MP:00020066.1BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
13MP:00053896.0BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
14MP:00053845.7BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
15MP:00036315.6BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
16MP:00053875.6BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
17MP:00053765.6BLMH, BRCA1, BRCA2, CCND1, ERCC2, IGF1
18MP:00053785.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
19MP:00107685.0BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Publications for Mutagen Sensitivity

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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension. (25918951)
2015
2
Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk. (24623229)
2014
3
Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. (21164199)
2011
4
Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and controls. (20391973)
2010
5
Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer. (20400363)
2010
6
Mutagen sensitivity: a genetic predisposition factor for cancer. (17440053)
2007
7
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)
2007
8
Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. (17035402)
2006
9
gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay. (16537698)
2006
10
DNA damage, oxidative mutagen sensitivity, and repair of oxidative DNA damage in nonmelanoma skin cancer patients. (16673411)
2006
11
High mutagen sensitivity in peripheral blood lymphocytes predicts poor overall and disease-specific survival in patients with stage III non-small cell lung cancer treated with radiotherapy and chemotherapy. (15837739)
2005
12
Differential mutagen sensitivity of peripheral blood lymphocytes from smokers and nonsmokers: effect of human cytomegalovirus infection. (15065204)
2004
13
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study. (14757193)
2004
14
Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. (15450412)
2004
15
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. (12611459)
2003
16
Mutagen sensitivity as a susceptibility marker for endometriosis. (14507820)
2003
17
From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. (12893086)
2003
18
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10984281)
2000
19
Mutagen sensitivity as a biomarker for second primary tumors after head and neck squamous cell carcinoma. (10919742)
2000
20
Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. (11173867)
2000
21
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10793110)
2000
22
Family history of cancer, mutagen sensitivity, and increased risk of head and neck cancer. (10656614)
1999
23
Genetics of smoking-related cancer and mutagen sensitivity. (10393708)
1999
24
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. (9676854)
1998
25
Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma. (9681523)
1998
26
Gamma-ray mutagen sensitivity and survival in patients with glioma. (9865917)
1998
27
Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells. (9624737)
1997
28
Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer. (9298575)
1997
29
Mutagen sensitivity and risk of gliomas: a case-control analysis. (8603389)
1996
30
Lack of effect of daily N-acetylcysteine supplementation on mutagen sensitivity. (8922306)
1996
31
Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. (7541679)
1995
32
Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck. (7539412)
1995
33
Mutagen sensitivity as a biological marker of lung cancer risk in African Americans. (7537995)
1995
34
Mutagen sensitivity and cancer susceptibility in patients with multiple primary cancers. (21597846)
1995
35
Mitotic catastrophe is the mechanism of lethality for mutations that confer mutagen sensitivity in Aspergillus nidulans. (7506362)
1994
36
Mutagen sensitivity as a marker of cancer risk. (7526974)
1994
37
Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. (7509776)
1994
38
Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract. (7966395)
1994
39
Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. (7688625)
1993
40
A novel phenotype of an excision-repair mutant in Neurospora crassa: mutagen sensitivity of the mus-18 mutant is specific to UV. (1832207)
1991
41
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. (1700135)
1990
42
Mutagen sensitivity and mutability in lentil. (24247709)
1986
43
Mutagen sensitivity of Drosophila melanogaster. VIII. The influence of the mei-41D5, mus(1)101D1, mus(1)102D1, mus(1)103D1, mus(2)205A1, and mus(3)310D1 loci on alkylation-induced mutagenesis. (3923336)
1985
44
Mutagen sensitivity of Drosophila melanogaster: VII. Alkylation mutagenesis of mature and immature oocytes of the excision-deficient mus (2) 201D1 mutant. (6434298)
1984
45
Mutagen sensitivity, smoking habits and enzyme induction in healthy middle-aged men. (6150846)
1984
46
Biochemical genetics of Neurospora nuclease II: Mutagen sensitivity and other characteristics of the nuclease mutants. (6309614)
1983
47
Mutagen sensitivity of Neurospora meiotic mutants. (6220799)
1983
48
Genetic control of mutagen sensitivity in Drosophila melanogaster: a new allele at the mei-9 locus on the X-chromosome. (107445)
1979
49
Mutagen sensitivity of wild type and recombination deficient c(3)G strains of Drosophila melanogaster. (121955)
1978
50
Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa. (188973)
1977

Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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Search GEO for disease gene expression data for Mutagen Sensitivity.

Pathways for genes affiliated with Mutagen Sensitivity

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Pathways related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
110.0BRCA1, TP53
2
Show member pathways
9.6BRCA1, BRCA2, TP53
39.5BRCA1, CCND1, TP53
49.5BRCA1, CCND1, TP53
59.4BRCA2, CCND1, XRCC1
69.2CCND1, DNMT1, TP53
79.1ERCC2, GSTM1, GSTT1, XPA
89.0ERCC2, TP53, XPA, XPC
9
Show member pathways
8.9ERCC2, RAD23B, XPA, XPC
108.8CCND1, IGF1, TP53
118.8BRCA1, BRCA2, CCND1, TP53, XRCC3
12
Show member pathways
8.7ERCC2, RAD23B, XPA, XPC, XRCC1
138.6BRCA1, CCND1, IGF1, TP53
148.4BRCA1, CCND1, DNMT1, DNMT3B, TP53
15
Show member pathways
8.3BRCA1, BRCA2, CCND1, IGF1, TP53
168.3BRCA1, BRCA2, CCND1, IGF1, TP53
177.7BRCA1, CCND1, ERCC2, RAD23B, TP53, XPA
18
Show member pathways
7.5BRCA1, BRCA2, ERCC2, RAD23B, TP53, XPA
19
Show member pathways
6.5BRCA1, BRCA2, CCND1, ERCC2, IGF1, RAD23B

GO Terms for genes affiliated with Mutagen Sensitivity

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Cellular components related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:007194210.6RAD23B, XPC
2replication forkGO:00056579.9DNMT1, TP53, XRCC3
3nucleusGO:00056345.7BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
4nucleoplasmGO:00056545.6BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
5cytoplasmGO:00057375.6BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Biological processes related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1chromosome breakageGO:003105210.5BRCA1, BRCA2
2chordate embryonic developmentGO:004300910.5BRCA1, BRCA2
3regulation of mitotic cell cycle phase transitionGO:190199010.3ERCC2, XPC
4protein sumoylationGO:001692510.3BRCA1, TP53, XPC
5mitotic G1 DNA damage checkpointGO:003157110.3CCND1, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2BRCA1, BRCA2, TP53
7response to auditory stimulusGO:001099610.2XPA, XPC
8UV-damage excision repairGO:007091410.2XPA, XPC
9DNA synthesis involved in DNA repairGO:000073110.1BRCA1, BRCA2, XRCC3
10strand displacementGO:000073210.1BRCA1, BRCA2, XRCC3
11positive regulation of protein import into nucleus, translocationGO:003316010.1BRCA1, IGF1
12double-strand break repair via homologous recombinationGO:000072410.0BRCA1, BRCA2, XRCC1, XRCC3
13intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.9BRCA1, BRCA2, XPA
14response to X-rayGO:00101659.9BRCA2, CCND1, TP53
15response to organic substanceGO:00100339.9CCND1, XRCC1, XRCC3
16base-excision repairGO:00062849.9TP53, XPA, XRCC1
17transcription-coupled nucleotide-excision repairGO:00062839.8ERCC2, XPA, XRCC1
18nucleotide-excision repair, DNA damage recognitionGO:00007159.8RAD23B, XPA, XPC
19S-adenosylmethioninamine metabolic processGO:00464999.7DNMT1, DNMT3B
20DNA methylation on cytosine within a CG sequenceGO:00104249.7DNMT1, DNMT3B
21S-adenosylhomocysteine metabolic processGO:00464989.7DNMT1, DNMT3B
22C-5 methylation of cytosineGO:00901169.6DNMT1, DNMT3B
23multicellular organism growthGO:00352649.6BRCA2, ERCC2, XPA
24response to nutrientGO:00075849.6BRCA1, BRCA2, IGF1
25negative regulation of histone H3-K9 methylationGO:00515739.5BRCA1, DNMT1, DNMT3B
26positive regulation of histone H3-K4 methylationGO:00515719.5BRCA1, DNMT1, DNMT3B
27nucleotide-excision repair, preincision complex assemblyGO:00062949.4ERCC2, RAD23B, XPA, XPC
28global genome nucleotide-excision repairGO:00709119.4ERCC2, RAD23B, XPA, XPC
29nucleotide-excision repair, DNA duplex unwindingGO:00007179.4ERCC2, RAD23B, XPA, XPC
30Ras protein signal transductionGO:00072659.3DNMT1, IGF1, TP53
31DNA repairGO:00062819.2ERCC2, XPA, XPC, XRCC1, XRCC3
32response to ionizing radiationGO:00102129.1BRCA1, DNMT1, DNMT3B, XRCC3
33positive regulation of gene expressionGO:00106289.0BRCA1, DNMT1, DNMT3B, TP53
34response to activityGO:00148238.9DNMT1, DNMT3B, IGF1
35response to caffeineGO:00310008.8DNMT1, DNMT3B, IGF1
36positive regulation of transcription, DNA-templatedGO:00458938.8BRCA1, BRCA2, ERCC2, IGF1, TP53
37nucleotide-excision repairGO:00062898.8BRCA2, ERCC2, RAD23B, TP53, XPA, XPC
38response to estradiolGO:00323558.6BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
39response to drugGO:00424938.5BLMH, CCND1, DNMT3B, XPC, XRCC1
40response to toxic substanceGO:00096368.5BLMH, DNMT1, DNMT3B, XPA
41cellular response to DNA damage stimulusGO:00069748.4BRCA1, BRCA2, CCND1, RAD23B, TP53, XPC
42response to hypoxiaGO:00016668.1DNMT3B, ERCC2, IGF1, XRCC1

Molecular functions related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:000369010.0DNMT1, TP53, XRCC3
2single-stranded DNA bindingGO:00036979.7BRCA2, RAD23B, XPC, XRCC3
3DNA (cytosine-5-)-methyltransferase activityGO:00038869.7DNMT1, DNMT3B
4DNA-methyltransferase activityGO:00090089.7DNMT1, DNMT3B
5unmethylated CpG bindingGO:00453229.7DNMT1, DNMT3B
6DNA (cytosine-5-)-methyltransferase activity, acting on CpG substratesGO:00517189.7DNMT1, DNMT3B
7histone deacetylase bindingGO:00428269.2CCND1, DNMT1, DNMT3B
8enzyme bindingGO:00198999.2BRCA1, CCND1, GSTM1, TP53, XRCC1
9damaged DNA bindingGO:00036849.2BRCA1, RAD23B, TP53, XPA, XPC, XRCC1
10protein bindingGO:00055154.5BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Sources for Mutagen Sensitivity

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet