MCID: MTG002
MIFTS: 36

Mutagen Sensitivity malady

Category: Rare diseases

Aliases & Classifications for Mutagen Sensitivity

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Aliases & Descriptions for Mutagen Sensitivity:

Name: Mutagen Sensitivity 45

Classifications:



Summaries for Mutagen Sensitivity

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MalaCards based summary: Mutagen Sensitivity is related to colorectal cancer and congenital pulmonary veins atresia or stenosis. An important gene associated with Mutagen Sensitivity is BRCA1 (Breast Cancer 1), and among its related pathways are Resolution of D-Loop Structures and BRCA1 Pathway. Affiliated tissues include lung, breast and lymph node, and related mouse phenotypes are limbs/digits/tail and pigmentation.

Related Diseases for Mutagen Sensitivity

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Diseases related to Mutagen Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer27.4BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, GSTM1
2congenital pulmonary veins atresia or stenosis10.5BRCA1, BRCA2
3bronchiolitis obliterans10.5BRCA1, BRCA2
4autoimmune polyendocrine syndrome type 110.4BRCA1, BRCA2
5autoimmune disease of urogenital tract10.4BRCA1, BRCA2
6malignant testicular leydig cell tumor10.4BRCA1, BRCA2
7breast cancer, childhood10.4BRCA1, BRCA2
8brca2 hereditary breast and ovarian cancer syndrome10.4BRCA1, BRCA2
9pancreatic cancer 410.4BRCA1, BRCA2
10mastitis10.4BRCA1, BRCA2
11vulvar alveolar soft part sarcoma10.3BRCA1, BRCA2
12pancreatic serous cystadenocarcinoma10.3BRCA1, BRCA2, TP53
13cystadenoma10.3BRCA1, BRCA2, TP53
14endometrial mucinous adenocarcinoma10.3BRCA1, BRCA2, TP53
15oral lichen planus10.3GSTM1, NAT2, XRCC1
16peritoneal cystic mesothelioma10.3BRCA1, BRCA2, TP53
17fallopian tube leiomyosarcoma10.3BRCA1, BRCA2, TP53
18uterine carcinosarcoma10.3BRCA1, BRCA2, TP53
19tetrasomy 2110.3BRCA1, BRCA2, TP53
20vascular dementia10.3BRCA1, BRCA2, TP53
21dyskinetic cerebral palsy10.3BRCA2, TP53, XRCC1
22retroperitoneal lymphoma10.3GSTM1, GSTT1, TP53
23ovary epithelial cancer10.3BRCA1, BRCA2, TP53
24filamentary keratitis10.3GSTM1, GSTT1, NAT2
25partial of retinal vein occlusion10.3BRCA1, BRCA2
26ovarian wilms' cancer10.3BRCA1, BRCA2, TP53
27spondyloepimetaphyseal dysplasia, sponastrime type10.3BRCA1, BRCA2, TP53
28common variable immunodeficiency10.3TP53, XRCC1, XRCC3
29ectodermal dysplasia10.3GSTM1, GSTT1, NAT2
30setariasis10.2BRCA1, BRCA2
313-methylglutaconic aciduria, type i10.2TP53, XPA, XPC
32acute monocytic leukemia10.2GSTM1, GSTT1, TP53
33microglandular adenosis10.2CCND1, TP53, XRCC1
34exposure keratitis10.1BRCA1, TP53
35choroid plexus papilloma10.1BRCA1, BRCA2, TP53, XPC
36integumentary system benign neoplasm10.1CCND1, GSTM1, TP53
37hepatitis10.1
38lymphoma10.1
39cholestasis10.1
40prostatitis10.1
41dermatitis10.1
42atopic dermatitis10.1
43neuronitis10.1
44endotheliitis10.1
45lipoadenoma10.0IGF1, TP53
46renal pelvis squamous cell carcinoma10.0CCND1, TP53
47glottis neoplasm10.0GSTM1, GSTT1, NAT2, XRCC1, XRCC3
48internal auditory canal lipoma10.0BRCA1, BRCA2, CCND1, TP53
49lymphatic system cancer10.0BRCA1, BRCA2, CCND1, TP53
50eye carcinoma in situ10.0BRCA1, BRCA2, CCND1, TP53

Graphical network of the top 20 diseases related to Mutagen Sensitivity:



Diseases related to mutagen sensitivity

Symptoms for Mutagen Sensitivity

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Drugs & Therapeutics for Mutagen Sensitivity

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Interventional clinical trials:

idNameStatusNCT IDPhase
1DNA Repair, p53 and Apoptosis Phenotypes in Lung CancerRecruitingNCT00339859
2Genetic Susceptibility to Bladder CancerRecruitingNCT00848289

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Genetic Tests for Mutagen Sensitivity

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Anatomical Context for Mutagen Sensitivity

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MalaCards organs/tissues related to Mutagen Sensitivity:

33
Lung, Breast, Lymph node, Bone, Thyroid, Smooth muscle, Prostate

Animal Models for Mutagen Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Mutagen Sensitivity:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9BLMH, BRCA1, BRCA2, IGF1, TP53, XPA
2MP:00011868.8BRCA1, DNMT1, ERCC2, TP53, XPA
3MP:00053808.5BRCA1, BRCA2, DNMT1, DNMT3B, RAD23B, TP53
4MP:00053758.1BRCA1, ERCC2, IGF1, RAD23B, TP53, XPA
5MP:00028737.9BRCA1, BRCA2, CCND1, DNMT1, IGF1, RAD23B
6MP:00053917.6CCND1, DNMT3B, ERCC2, RAD23B, TP53, XPA
7MP:00053796.9BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
8MP:00053906.7BRCA1, BRCA2, CCND1, DNMT3B, ERCC2, IGF1
9MP:00053866.7BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
10MP:00053976.4BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
11MP:00107716.4BLMH, BRCA1, BRCA2, CCND1, DNMT1, ERCC2
12MP:00020066.3BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
13MP:00036316.2BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
14MP:00053766.0BLMH, BRCA1, BRCA2, CCND1, ERCC2, IGF1
15MP:00053896.0BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
16MP:00053875.8BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
17MP:00053845.8BRCA1, BRCA2, CCND1, DNMT1, DNMT3B, ERCC2
18MP:00053785.3BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B
19MP:00107685.1BLMH, BRCA1, BRCA2, CCND1, DNMT1, DNMT3B

Publications for Mutagen Sensitivity

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Articles related to Mutagen Sensitivity:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma. (26870165)
2016
2
Correlation between CCR7 expression and lymph node metastatic potential of human tongue carcinoma. (24528991)
2015
3
Ectopic pregnancy at the Ignace Deen University Hospital in Conakry: Epidemiologic, social, demographic, therapeutic, and prognostic aspects. (25370048)
2014
4
Response to oral acitretin in lichen amyloidosis. (25593815)
2014
5
Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases. (23729584)
2013
6
Profile and outcome of infantile nephrotic syndrome treated in a tertiary care center. (23354212)
2013
7
Recalcitrant neovascular macular degeneration after anti-VEGF therapy: an ongoing challenge. (23510034)
2013
8
Apically displaced papillary muscles mimicking apical hypertrophic cardiomyopathy. (22715501)
2013
9
Newborn Screening for Sickle Cell Disease in India: The Need for Defining Optimal Clinical Care. (24037477)
2013
10
Digital necrosis due to cryofibrinogen in granulomatosis with polyangiitis - a new association. (24184567)
2013
11
Involvement of ER-I+36 in the malignant growth of gastric carcinoma cells is associated with GRP94 overexpression. (23829397)
2013
12
CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders. (24045551)
2013
13
Modeling and simulating dynamics of complete- and poor-response chronic hepatitis B chinese patients for adefovir and traditional chinese medicine plus adefovir therapy. (24282437)
2013
14
Reproductive factors and risk of esophageal squamous cell carcinoma in northern Iran: a case-control study in a high-risk area and literature review. (23238586)
2013
15
LRP4 association to bone properties and fracture and interaction with genes in the Wnt- and BMP signaling pathways. (21645651)
2011
16
Role of adenosine 5'-triphosphate in regulating renal microvascular function and in hypertension. (21768526)
2011
17
A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899. (20178647)
2010
18
Ascorbate-apatite composite and ascorbate-FGF-2-apatite composite layers formed on external fixation rods and their effects on cell activity in vitro. (19375998)
2009
19
Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. (19620293)
2009
20
Small-bowel diagnosis in patients with familial adenomatous polyposis: comparison of push enteroscopy, capsule endoscopy, ileoscopy, and enteroclysis. (19358059)
2009
21
A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells. (18992240)
2009
22
Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells. (18245228)
2008
23
Multimodality imaging of a spontaneous cerebrospinal fluid leak. (17314599)
2007
24
Valsartan in the treatment of heart failure or left ventricular dysfunction after myocardial infarction. (17969373)
2007
25
N-cadherin engagement provides a dominant stop signal for the migration of MDA-MB-468 breast carcinoma cells. (17171299)
2007
26
The cation-independent mannose 6-phosphate receptor is involved in lysosomal delivery of serglycin. (17210618)
2007
27
Ximelagatran: direct thrombin inhibitor. (17319469)
2006
28
Characteristics of CADASIL in Korea: a novel cysteine-sparing Notch3 mutation. (16717210)
2006
29
Immunodetection of GLUT1, p63 and phospho-histone H1 in invasive head and neck squamous carcinoma: correlation of immunohistochemical staining patterns with keratinization. (16681688)
2006
30
Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance. (16128592)
2005
31
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. (14744763)
2004
32
Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis. (12941704)
2003
33
Neuroaxonal dystrophy in raccoons (Procyon lotor) from Iowa. (11939344)
2002
34
The association between a negatively charged ligand and the electronegative binding pocket of its receptor. (11807752)
2002
35
Brainstem auditory evoked potentials and cochlear microphonics in the HMSN family with auditory neuropathy. (10653192)
2000
36
Oxidized low density lipoproteins regulate synthesis of monkey aortic smooth muscle cell proteoglycans that have enhanced native low density lipoprotein binding properties. (10671509)
2000
37
Mirtazapine: an inhibitor of cortisol secretion that does not influence growth hormone and prolactin secretion. (10653218)
2000
38
A polymorphic marker in the leptin gene associated with Japanese morbid obesity. (11140377)
2000
39
Inhibitory effects of higenamine on dopamine content in PC12 cells. (10418335)
1999
40
No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate. (9433483)
1997
41
RecA as a motor protein. Testing models for the role of ATP hydrolysis in DNA strand exchange. (9211918)
1997
42
Cytokine mRNA repertoire of articular chondrocytes from arthritic patients, infants, and neonatal mice. (8853228)
1996
43
Clinical and enzymatic investigation of induction of oxygen free radicals by ischemia and reperfusion in human hepatocellular carcinoma and adjacent liver. (7547624)
1995
44
3-Methylglutaconic aciduria, type 3. (7573769)
1995
45
Role of the leucine zipper in the kinetics of DNA binding by transcription factor USF. (7982989)
1994
46
PTH and bone markers of renal osteodystrophy in predialysis chronic renal failure. (1300330)
1992
47
Left hepatic atrophy in Mirizzi syndrome: CT appearance. (2357992)
1990
48
The effect of preoperative convergence exercises on the surgical outcome of primary exotropia. (555804)
1979
49
Neutropenia associated with splenomegaly and atrophic arthritis (Felty's syndrome); report of a case in which splenectomy was performed. (15411128)
1950
50

Variations for Mutagen Sensitivity

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Expression for genes affiliated with Mutagen Sensitivity

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Search GEO for disease gene expression data for Mutagen Sensitivity.

Pathways for genes affiliated with Mutagen Sensitivity

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Pathways related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA1, BRCA2, XRCC3
2
Show member pathways
9.7BRCA1, BRCA2, TP53
39.5BRCA2, CCND1, XRCC1
49.4BRCA1, CCND1, TP53
59.4BRCA1, CCND1, TP53
69.4BRCA1, BRCA2, TP53, XPC
79.2CCND1, DNMT1, TP53
89.0CCND1, IGF1, TP53
98.9BRCA1, BRCA2, CCND1, TP53, XRCC3
108.8ERCC2, GSTM1, GSTT1, XPA
11
Show member pathways
8.8BRCA1, CCND1, IGF1, TP53
128.7ERCC2, TP53, XPA, XPC
13
Show member pathways
8.6ERCC2, RAD23B, XPA, XPC
148.5BRCA1, BRCA2, CCND1, IGF1, TP53
15
Show member pathways
8.5BRCA1, BRCA2, CCND1, IGF1, TP53
168.4BRCA1, CCND1, DNMT1, DNMT3B, TP53
17
Show member pathways
8.4ERCC2, RAD23B, XPA, XPC, XRCC1
18
Show member pathways
7.3BRCA1, BRCA2, ERCC2, RAD23B, TP53, XPA
19
Show member pathways
6.4BRCA1, BRCA2, CCND1, ERCC2, IGF1, RAD23B

GO Terms for genes affiliated with Mutagen Sensitivity

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Biological processes related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1DNA synthesis involved in DNA repairGO:000073110.4BRCA1, BRCA2
2chordate embryonic developmentGO:004300910.4BRCA1, BRCA2
3response to auditory stimulusGO:001099610.3XPA, XPC
4response to gamma radiationGO:001033210.3BRCA2, TP53
5intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.3BRCA2, TP53
6double-strand break repair via homologous recombinationGO:000072410.2BRCA1, BRCA2, XRCC1
7UV-damage excision repairGO:007091410.2XPA, XPC
8double-strand break repair via synthesis-dependent strand annealingGO:004500310.2BRCA1, BRCA2, XRCC3
9DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1BRCA1, BRCA2, TP53
10intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.1BRCA1, BRCA2, XPA
11nucleotide-excision repair, DNA damage recognitionGO:000071510.0RAD23B, XPC
12protein sumoylationGO:001692510.0BRCA1, TP53, XPC
13response to ionizing radiationGO:001021210.0BRCA1, DNMT1, XRCC3
14nucleotide-excision repair, preincision complex stabilizationGO:00062939.8ERCC2, XPA
15response to vitamin AGO:00331899.8DNMT1, DNMT3B
16nucleotide-excision repair, preincision complex assemblyGO:00062949.8RAD23B, XPA, XPC
17transcription-coupled nucleotide-excision repairGO:00062839.6ERCC2, XPA, XRCC1
18positive regulation of DNA bindingGO:00433889.5ERCC2, IGF1
19negative regulation of histone H3-K9 methylationGO:00515739.5DNMT1, DNMT3B
20global genome nucleotide-excision repairGO:00709119.3ERCC2, XPA, XRCC1
21negative regulation of transcription, DNA-templatedGO:00458929.3BRCA1, DNMT1, DNMT3B, TP53
22DNA methylation on cytosine within a CG sequenceGO:00104249.2DNMT1, DNMT3B
23positive regulation of histone H3-K4 methylationGO:00515719.2BRCA1, DNMT1, DNMT3B
24response to drugGO:00424939.2DNMT1, DNMT3B, XPC, XRCC1
25response to organic substanceGO:00100339.0DNMT1, IGF1, XRCC1, XRCC3
26DNA repairGO:00062818.9BRCA1, ERCC2, XPA, XPC
27response to activityGO:00148238.9DNMT1, DNMT3B, IGF1
28cellular response to DNA damage stimulusGO:00069748.4BRCA1, BRCA2, CCND1, RAD23B, TP53, XPC

Molecular functions related to Mutagen Sensitivity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA-methyltransferase activityGO:00090089.5DNMT1, DNMT3B
2unmethylated CpG bindingGO:00453229.5DNMT1, DNMT3B
3single-stranded DNA bindingGO:00036979.1BRCA2, RAD23B, XPC, XRCC3
4DNA-dependent ATPase activityGO:00080949.1ERCC2, XRCC3

Sources for Mutagen Sensitivity

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet