Mutagen Sensitivity malady

MalaCards: Mutagen Sensitivity is related to colorectal cancer and ataxia telangiectasia. An important gene associated with Mutagen Sensitivity is BLMH (bleomycin hydrolase), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and Transcription P53 signaling pathway. The compounds vinylchloride and arylamine have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and b cells, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

mutagen sensitivity 30

Diseases related to mutagen sensitivity by text searches and GeneDecks gene sharing:

(show top 50)    (show all 260)

id	Related Disease	Score	Top Affiliating Genes
1	colorectal cancer	28.2	NAT2, GSTM1, GSTT1, TP53
2	ataxia telangiectasia	24.6	PCNA, BRCA1, BRCA2, BLM, XRCC1, XRCC3
3	barrett's esophagus	24.6	PCNA, XRCC1, GSTM1, GSTT1, IGFBP3, IGF1
4	ataxia	23.8	PCNA, BRCA1, BRCA2, RAD23B, BLM, XRCC1
5	colon cancer	21.7	PCNA, NAT2, BRCA1, BRCA2, BLM, XRCC1
6	xeroderma pigmentosum	13.5	XPA, XPC
7	cerebrooculofacioskeletal syndrome	13.4	ERCC2, ERCC5
8	radiation induced cancer	13.4	BRCA1, XPC
9	photosensitive trichothiodystrophy	13.3	XPA, ERCC2, ERCC5
10	xeroderma pigmentosum, group d	13.3	XRCC1, XPC, ERCC2
11	immunodeficiency, centromere instability and facial anomalies syndrome	13.3	DNMT3B, DNMT1
12	skin benign neoplasm	13.2	XPA, XPC, ERCC2
13	schimke immunoosseous dysplasia	13.1	XPA, XPC, ERCC2
14	brca1 and brca2 hereditary breast and ovarian cancer	13.1	BRCA1, BRCA2
15	fallopian tube carcinoma	13.1	BRCA1, BRCA2
16	li-fraumeni-like syndrome	13.0	BRCA2, TP53
17	drug-induced hepatitis	12.9	NAT2, GSTM1, GSTT1
18	xeroderma pigmentosum, group c	12.9	RAD23B, XPC, ERCC5, TP53
19	photosensitive trichthiodystrophy	12.9	RAD23B, XPA, XPC, ERCC2, ERCC5
20	alcoholic pancreatitis	12.9	NAT2, GSTM1, GSTT1
21	diffuse gastric cancer	12.9	XRCC3, GSTM1, GSTT1, ERCC2
22	biliary tract cancer	12.8	RAD23B, XRCC1, XRCC3, TP53
23	ehlers-danlos syndrome	12.8	XRCC1, GSTM1, GSTT1, ERCC2
24	myelodysplastic syndrome	12.8	GSTM1, GSTT1, DNMT3B, DNMT1
25	diabetic polyneuropathy	12.8	GSTM1, GSTT1, TP53
26	skin carcinoma	12.8	GSTM1, GSTT1, TP53
27	insulin-like growth factor 1 resistance to	12.7	IGFBP3, IGF1
28	diffuse idiopathic skeletal hyperostosis	12.6	IGFBP3, IGF1
29	varicocele	12.6	GSTM1, GSTT1, TP53
30	nijmegen breakage syndrome	12.6	BRCA1, BLM, TP53
31	pneumoconiosis	12.6	GSTM1, GSTT1, TP53
32	hereditary breast ovarian cancer	12.6	BRCA1, BRCA2, TP53
33	rabson-mendenhall syndrome	12.6	IGFBP3, IGF1
34	acute lymphoblastic leukemia, childhood	12.6	XRCC1, GSTM1, GSTT1
35	breast carcinoma in situ	12.6	BRCA1, BRCA2, TP53
36	lynch syndrome	12.6	BRCA1, BRCA2
37	cardia cancer	12.6	XRCC1, GSTM1, GSTT1, TP53
38	peritoneal carcinoma	12.6	BRCA1, BRCA2, TP53
39	bilateral breast cancer	12.6	BRCA1, BRCA2, TP53
40	idiopathic juvenile osteoporosis	12.6	IGFBP3, IGF1
41	hereditary mucosal leukokeratosis	12.5	PCNA, GSTM1
42	spitz nevus	12.5	PCNA, TP53
43	myeloid malignancy	12.5	GSTM1, GSTT1, TP53, DNMT1
44	rheumatoid arthritis, association with	12.5	NAT2, GSTM1, IGF1
45	familial pancreatic cancer	12.5	BRCA1, BRCA2, FANCG, TP53
46	familial prostate cancer	12.5	BRCA1, BRCA2, GSTM1, GSTT1
47	oral cavity cancer	12.5	NAT2, GSTM1, GSTT1, TP53
48	bladder cancer susceptibility	12.5	NAT2, XRCC1, GSTM1, GSTT1, ERCC2
49	urinary bladder cancer	12.4	NAT2, GSTM1, GSTT1, TP53
50	retinopathy of prematurity	12.4	GSTM1, GSTT1, IGF1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to mutagen sensitivity:

²²

MGI Mouse Phenotypes related to mutagen sensitivity:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.1	FANCG, XPA, BRCA2, RAD23B, BRCA1
2	reproductive system phenotype	MP:0005389	8.8	ERCC2, BRCA1, FANCG, BRCA2, RAD23B, XPA
3	nervous system phenotype	MP:0003631	8.7	ERCC2, REV3L, BRCA1, XPA, XPC, TOPBP1
4	pigmentation phenotype	MP:0001186	8.6	BRCA1, XPA, ERCC2, TP53, DNMT1
5	behavior/neurological phenotype	MP:0005386	8.4	BLMH, ERCC2, GSTM1, XPC, XPA, XRCC1
6	embryogenesis phenotype	MP:0005380	8.0	REV3L, BRCA1, BRCA2, RAD23B, BLM, XRCC1
7	adipose tissue phenotype	MP:0005375	7.5	BRCA1, RAD23B, XPA, IGFBP3, IGF1, TP53
8	immune system phenotype	MP:0005387	7.2	DNMT1, DNMT3B, TP53, ERCC5, ERCC2, XPA
9	normal phenotype	MP:0002873	7.1	BRCA2, RAD23B, BRCA1, DNMT1, TOPBP1, TP53
10	integument phenotype	MP:0010771	6.9	BRCA1, DNMT1, ERCC5, ERCC2, IGF1, XPA
11	mortality/aging	MP:0010768	6.9	TOPBP1, TP53, ERCC5, XPC, XPA, XRCC1
12	tumorigenesis	MP:0002006	6.8	BLM, DNMT1, DNMT3B, BRCA2, TP53, REV3L
13	hematopoietic system phenotype	MP:0005397	5.9	BRCA1, XPA, IGF1, ERCC2, ERCC5, TP53
14	growth/size phenotype	MP:0005378	5.6	BRCA1, ERCC2, IGF1, IGFBP3, XPC, XPA
15	homeostasis/metabolism phenotype	MP:0005376	5.2	BLMH, RAD23B, BRCA2, BRCA1, XRCC1, REV3L
16	cellular phenotype	MP:0005384	4.9	REV3L, XRCC1, XPC, GSTM1, FANCG, XPA

Articles related to mutagen sensitivity:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Micronuclei frequency induced by bleomycin in human peripheral lymphocytes: correlating BLHX polymorphism with mutagen sensitivity. (18082847)	Maffei F.... Hrelia P.	2008	BLMH
2	Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (17953974)	Angelini S.... Hrelia P.	2008	ERCC2, GSTT1, GSTM1
3	Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. (18499700)	Leng S.... Belinsky S.A.	2008	DNMT3B, DNMT1
4	Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. (17932354)	Lin J.... Wu X.	2007	XPC, XPA, RAD23B
5	Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis. (17035402)	Chao D.L.... Vaughan T.L.	2006	TP53
6	Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer. (16703596)	Minard C.G.... Etzel C.J.	2006	GSTT1, GSTM1
7	Mutagen sensitivity of human lymphoblastoid cells wit h a BRCA1 mutation. (12611459)	Trenz K.... Speit G.	2003	BRCA1
8	From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. (12893086)	Wang Y.... Wu X.	2003	XRCC1
9	Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (12082022)	Tuimala J.... Norppa H.	2002	GSTT1, GSTM1, BLMH
10	Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. (11890937)	Trenz K.... Speit G.	2002	BRCA1, BRCA2
11	Mutagen sensitivity and p53 expression in colorectal cancer in China. (11677281)	Shao L.... Huang Q.	2001	TP53
12	Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. (11173867)	Speit G.... DAPrk T.	2000	BRCA1
13	Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. (10793110)	Wu X.... Spitz M.R.	2000	IGF1, IGFBP3
14	The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (9256465)	Liu N.... Thompson L.H.	1997	FANCG
15	The polymorphism of GSTM1, mutagen sensitivity in colon cancer and healthy control. (9003527)	Guo J.Y.... Zhang Q.	1996	GSTM1

Genes related to mutagen sensitivity according to GeneCards:

(show all 25)

id	Symbol	Description	Score	GeneCards Section Context
1	BLMH	bleomycin hydrolase	11.0	Publications
2	HELQ	helicase, POLQ-like	11.0	Orthologs
3	FANCG	Fanconi anemia, complementation group G	11.0	Publications
4	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	11.0	Publications
5	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Orthologs
6	TOPBP1	topoisomerase (DNA) II binding protein 1	11.0	Orthologs
7	XPC	xeroderma pigmentosum, complementation group C	11.0	Orthologs, Publications
8	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
9	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	11.0	Publications
10	RAD23B	RAD23 homolog B (S. cerevisiae)	11.0	Publications
11	POLQ	polymerase (DNA directed), theta	11.0	Orthologs
12	REV3L	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	11.0	Orthologs
13	XPA	xeroderma pigmentosum, complementation group A	11.0	Publications
14	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
15	BLM	Bloom syndrome, RecQ helicase-like	11.0	Orthologs
16	DNMT1	DNA (cytosine-5-)-methyltransferase 1	11.0	Publications
17	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.0	Publications
18	GSTM1	glutathione S-transferase mu 1	11.0	Publications
19	GSTT1	glutathione S-transferase theta 1	11.0	Publications
20	BRCA2	breast cancer 2, early onset	11.0	Publications
21	BRCA1	breast cancer 1, early onset	11.0	Publications
22	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
23	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
24	PCNA	proliferating cell nuclear antigen	11.0	Orthologs
25	TP53	tumor protein p53	11.0	Publications

Pathways related to mutagen sensitivity according to GeneDecks:

(show all 24)

id	Pathway	Score	Top Affiliating Genes
1	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.5	BLM
2	Transcription P53 signaling pathway10	10.2	TP53
3	Dual incision reaction in GG-NER38	10.0	ERCC5, RAD23B, XPC, XPA
4	Homologous recombination20	9.8	XRCC3, BLM, BRCA2
5	Fluoropyrimidine Pathway, Pharmacodynamics34	9.7	TP53, ERCC2, XRCC3
6	Fanconis Anaemia Pathway36	9.6	BRCA1, FANCG, BRCA2
7	Signal transduction_PTEN pathway41	9.6	PCNA
8	DNA damage DNA-damage-induced responses10	9.5	TP53, BRCA1
9	Meiosis10	9.5	BRCA1, BLM, XRCC1, TOPBP1, FANCG
10	Transcription_P53 signaling pathway41	9.4	XPA, TP53, ERCC2, XPC
11	DNA damage_DNA-damage-induced responses41	9.2	TP53, BRCA1
12	Selected targets of Oct-3/410	9.2	BRCA1, DNMT1, TP53, DNMT3B
13	Nucleotide excision repair20	9.2	PCNA, RAD23B, XPC, ERCC5, XPA
14	Nucleotide Excision Repair Pathway36	9.2	ERCC5, RAD23B, XPA, PCNA, XPC
15	BRCA1 Pathway36	9.0	BRCA1, FANCG, TP53, BLM, BRCA2
16	DNA Damage3	8.9	BLM, TP53, XRCC1, BRCA2, BRCA1
17	GADD45 Pathway36	8.8	PCNA, BRCA1, TP53
18	Chks in Checkpoint Regulation36	8.7	PCNA, BRCA1, TP53
19	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.7	BLM, PCNA, BRCA1, TP53
20	Signal transduction PTEN pathway10	8.6	IGF1, TP53, PCNA
21	DNA damage Role of Brca1 and Brca2 in DNA repair10	8.4	PCNA, BRCA2, TP53, BRCA1, XPC
22	DNA damage_Role of Brca1 and Brca2 in DNA repair41	8.4	XPC, PCNA, TP53, BRCA1, BRCA2
23	Cell Cycle / Checkpoint Control3	8.1	BLM, XRCC1, TP53, BRCA2, PCNA, BRCA1
24	DNA Repair Mechanisms36	6.3	BRCA1, POLQ, TP53, ERCC5, XPC, IGF1

Compounds related to mutagen sensitivity according to GeneDecks:

(show top 50)    (show all 100)

id	Compound	Score	Top Affiliating Genes
1	vinylchloride32	9.8	XRCC1, GSTM1, GSTT1
2	arylamine32	9.7	GSTM1, NAT2, GSTT1
3	styrene32	9.6	GSTT1, GSTM1, NAT2
4	1-hydroxypyrene32	9.6	NAT2, GSTT1, GSTM1
5	gsts32	9.6	GSTM1, XRCC1, NAT2, GSTT1
6	benzene32	9.5	GSTM1, NAT2, XRCC1, XRCC3, GSTT1
7	benzidine32	9.5	GSTT1, GSTM1, NAT2
8	platinum32	9.4	GSTT1, BRCA1, XRCC1, ERCC2
9	trichloroethylene32	9.4	NAT2, GSTM1, GSTT1
10	cotinine32 18	10.4	GSTM1, GSTT1, ERCC2, XRCC1, NAT2
11	epoxide32	9.4	NAT2, XRCC1, GSTT1, GSTM1
12	5-methylcytosine32 18	10.3	DNMT1, DNMT3B, TP53, BRCA1
13	aflatoxin b132 18	10.3	GSTM1, GSTT1, TP53, NAT2
14	etoposide32 42 9 9	12.3	XRCC1, TP53, PCNA
15	p00332	9.2	BRCA2, XRCC3, IGFBP3, BRCA1
16	bpde32	9.1	GSTT1, BRCA1, TP53, GSTM1
17	hydrocarbons32	9.1	ERCC2, GSTT1, NAT2, BRCA1, GSTM1
18	diepoxybutane32	9.1	GSTM1, XRCC1, NAT2, GSTT1, BRCA1, FANCG
19	p00232	9.0	XRCC1, BRCA1, BRCA2, GSTM1, GSTT1
20	progesterone32 42 9 18 9	12.8	PCNA, BRCA1, DNMT1, BRCA2
21	8-oxo-dg32	8.8	PCNA, TP53, GSTM1, GSTT1
22	o6-methylguanine32	8.7	DNMT1, TP53, BRCA2, PCNA
23	mspi32	8.7	GSTT1, ERCC2, DNMT1, GSTM1, XRCC1, BRCA2
24	betacarotene32	8.6	GSTM1, XRCC1, PCNA, NAT2, IGFBP3
25	adriamycin32	8.5	BRCA2, BRCA1, IGF1, TP53, DNMT1
26	caffeine32 34 9 18 9	12.5	TP53, XRCC3, BRCA1, NAT2, PCNA
27	oxaliplatin32 34 9 9	11.4	ERCC2, GSTT1, GSTM1, XPA, XRCC1, TP53
28	benzo(a)pyrene32	8.3	XPC, NAT2, BRCA1, TP53, GSTT1, GSTM1
29	8-oxoguanine32	8.3	BRCA2, GSTT1, BRCA1, PCNA, XRCC1, GSTM1
30	bleomycin32 9 9	10.3	BRCA1, BRCA2, BLMH, XRCC1, GSTM1, IGF1
31	methylmethanesulfonate32	8.2	TP53, XRCC1, BRCA2, BLM, BRCA1, PCNA
32	hydroxyurea32 9 9	10.2	TOPBP1, TP53, BLM, BRCA1, PCNA, BRCA2
33	thymidylate32	8.2	BRCA1, TP53, ERCC2, GSTM1, XRCC1, PCNA
34	adpribose32	8.2	BRCA1, BRCA2, XRCC1, TP53, DNMT1, PCNA
35	mitomycin c32	8.1	XPA, BRCA2, XRCC3, BRCA1, PCNA, TP53
36	lycopene32 18	9.1	BRCA1, PCNA, IGF1, BRCA2, IGFBP3
37	camptothecin32 42 9 9	11.0	BLM, XRCC1, PCNA, BRCA2, TP53, XRCC3
38	5-aza-2deoxycytidine32	7.9	DNMT1, TP53, DNMT3B, BRCA1, IGFBP3, PCNA
39	methotrexate32 34 42 9 9	11.6	ERCC2, BRCA2, BRCA1, NAT2, PCNA, GSTM1
40	5fluorouracil32	7.6	ERCC2, XRCC1, GSTM1, IGFBP3, PCNA, TP53
41	doxorubicin32 34 9 9	10.6	TP53, IGFBP3, GSTT1, GSTM1, BRCA1, DNMT1
42	glutamine32	7.5	PCNA, BRCA2, RAD23B, XRCC1, IGFBP3, BRCA1
43	creatinine32	7.5	IGFBP3, IGF1, DNMT1, GSTM1, GSTT1, PCNA
44	paclitaxel32 34 9 9	10.3	PCNA, BRCA1, BRCA2, IGFBP3, ERCC2, TP53
45	folate32	7.2	NAT2, BRCA1, BRCA2, XRCC1, XRCC3, GSTM1
46	thymidine32 18	8.0	BRCA1, PCNA, TP53, IGFBP3, IGF1, DNMT1
47	tamoxifen32 34 9 9	10.0	TP53, DNMT1, PCNA, BRCA1, BRCA2, IGFBP3
48	oligonucleotide32	6.7	PCNA, XPA, DNMT3B, TP53, GSTT1, XPC
49	cisplatin32 34 9 9	9.1	FANCG, DNMT1, TP53, REV3L, PCNA, BRCA1
50	estrogen32	6.0	BRCA1, BRCA2, GSTM1, PCNA, NAT2, TP53

Cellular components related to mutagen sensitivity according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	XPC complex	GO:071942	10.0	RAD23B, XPC
2	replication fork	GO:005657	9.9	DNMT1, BLM
3	insulin-like growth factor binding protein complex	GO:016942	9.0	IGF1, IGFBP3
4	nucleoplasm	GO:005654	6.6	PCNA, BRCA1, BRCA2, RAD23B, XRCC1, XPA
5	nucleus	GO:005634	4.8	PCNA, DNMT1, DNMT3B, TOPBP1, HELQ, BRCA1

Biological processes related to mutagen sensitivity according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide-excision repair, DNA damage recognition	GO:000715	10.3	XPC, RAD23B
2	replication fork protection	GO:048478	9.9	BLM, BRCA2
3	response to UV-C	GO:010225	9.9	BRCA2, ERCC5
4	negative regulation of histone H3-K9 methylation	GO:051573	9.8	DNMT3B, BRCA1, DNMT1
5	positive regulation of histone H3-K4 methylation	GO:051571	9.8	DNMT1, DNMT3B, BRCA1
6	response to ionizing radiation	GO:010212	9.7	TOPBP1, DNMT3B, BRCA1
7	nucleotide-excision repair, DNA damage removal	GO:000718	9.6	XPA, ERCC5, ERCC2, XPC, RAD23B
8	cell cycle checkpoint	GO:000075	9.4	TP53, FANCG, ERCC2, XPC
9	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.3	TP53, BRCA2, BRCA1
10	double-strand break repair via homologous recombination	GO:000724	9.2	BLM, BRCA1, BRCA2
11	transcription-coupled nucleotide-excision repair	GO:006283	9.2	ERCC2, ERCC5, PCNA
12	base-excision repair	GO:006284	9.1	TP53, XRCC1, PCNA
13	response to DNA damage stimulus	GO:006974	9.1	BRCA1, TOPBP1, BLM, TP53, XRCC3
14	multicellular organism growth	GO:035264	8.8	TP53, BRCA2, IGF1, ERCC5, ERCC2
15	double-strand break repair	GO:006302	8.8	BRCA1, BRCA2, TP53
16	positive regulation of transcription, DNA-dependent	GO:045893	8.1	ERCC2, IGF1, TP53, BLM, BRCA2, BRCA1
17	nucleotide-excision repair	GO:006289	7.9	TP53, BRCA2, RAD23B, XPA, XPC, ERCC2
18	DNA repair	GO:006281	6.7	BLM, BRCA1, BRCA2, RAD23B, XRCC1, XRCC3

Molecular functions related to mutagen sensitivity according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA-methyltransferase activity	GO:009008	9.9	DNMT3B, DNMT1
2	bubble DNA binding	GO:000405	9.8	BLM, ERCC5, XPC
3	ATP-dependent helicase activity	GO:008026	9.8	HELQ, POLQ, BLM
4	DNA (cytosine-5-)-methyltransferase activity	GO:003886	9.7	DNMT3B, DNMT1
5	damaged DNA binding	GO:003684	9.4	XPC, RAD23B, XRCC1, XPA, POLQ, FANCG
6	single-stranded DNA binding	GO:003697	9.3	ERCC5, XPC, RAD23B, BRCA2, BLM
7	protein binding	GO:005515	4.4	XRCC1, BLMH, BLM, ERCC5, RAD23B, XRCC3